120 results match your criteria Colloid Milium
NPJ Parkinsons Dis 2018 15;4:18. Epub 2018 Jun 15.
1Parkinson's Institute and Clinical Center, Sunnyvale, CA USA.
The "Iowa kindred," a large Iowan family with autosomal-dominant Parkinson's disease, has been followed clinically since the 1920s at the Mayo Clinic. In 2003, the genetic cause was determined to be a 1.7 Mb triplication of the alpha-synuclein genomic locus. Read More
Int J Dermatol 2018 May 27. Epub 2018 May 27.
Dermatology Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Tunis Med 2016 Oct;94(10):632
Tunis Med 2016 Oct;94(8-9):632
Int J Dermatol 2017 Aug 30;56(8):878-880. Epub 2017 Jun 30.
Department of Dermatology, Civil Hospital "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico.
J Cosmet Dermatol 2017 Dec 9;16(4):e45-e47. Epub 2017 Mar 9.
Dermatology Department, University of Pennsylvania, Philadelphia, PA, USA.
Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh-colored papules or plaques on sun-exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52-year-old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid. Read More
Pediatr Dermatol 2016 May 4;33(3):e201-e203. Epub 2016 Apr 4.
Dermatology Department, Sana'a University, Sana'a, Yemen.
Juvenile colloid milium is an extremely rare degenerative dermatosis of the dermal connective tissue manifesting before puberty. This chronic skin condition, detected primarily in sun-exposed areas, is clinically characterized by the development of translucent, yellowish papules and plaques containing gelatinous material and by the presence of eosinophilic, fissured material in the papillary dermis. We present two cases of juvenile colloid milium, in a 13-year-old girl and her 10-year-old brother; the condition emerged in both at approximately 6 years of age and progressively worsened. Read More
Ann Pathol 2016 Apr 16;36(2):130-3. Epub 2016 Mar 16.
Service de dermatologie et de vénéréologie, hôpital d'instruction des armées Sainte-Anne, 83800 Toulon, France.
The colloid milium has four clinical forms: adult colloid milium, juvenile colloid milium, paracolloid (or nodular colloid degeneration) and pigmented colloid milium. We report the case of an adult colloid milium in a man of 56, who presented episodes of diffuse pruritus associated with myalgia and digestive disorders, indicative of trichinosis. He also developed gradually over the past 10 years, yellowish injuries in the mandibles and neck for whom histology objectified a colloid milium. Read More
Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S87-S89
*Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; and †Cutaneous Pathology PA and Wake Forest University School of Medicine, Winston-Salem, North Carolina, U.S.A.
Colloid milium is a rare deposition disorder with accumulation of a characteristic amorphous substance in both protected and sun-exposed areas depending upon the disease subtype. The patient was a 59-year-old woman who was referred for evaluation of a gelatinous-appearing mass in the inferior fornix of the right eye, extending from the medial to the lateral canthal region, and extending up onto the bulbar conjunctival surface and anterior lacrimal gland. Hematoxylin and eosin stain of an incisional biopsy showed deposits of an amorphous brightly eosinophilic material within the conjunctiva with scattered plasma cells at the periphery. Read More
J Dermatol Case Rep 2015 Jun 30;9(2):42-5. Epub 2015 Jun 30.
Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences, Iran; ; Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Background: Colloid milium is a rare cutaneous deposition disorder characterized by translucent papules developing on sun-exposed regions such as the face, neck and dorsal aspects of the hands and back. Exogenous ochronosis is caused by the accumulation of homogentisic acid resulting from long-term application of certain topical agents. Histology is characterized by yellow-brown pigment deposits in the papillary dermis. Read More
Indian Dermatol Online J 2014 Nov;5(Suppl 1):S36-9
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nodular colloid degeneration (NCD) is a rare dermatological disorder and uncommon type of colloid milium. The degeneration may be related to sun exposure. In this report, three cases, all presenting as multiple plaques and nodules over the nose and the face are depicted. Read More
J Eur Acad Dermatol Venereol 2016 Mar 2;30(3):490-1. Epub 2014 Dec 2.
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dermatol Ther 2014 Mar-Apr;27(2):68-70. Epub 2013 May 2.
Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, China.
Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure. The most common clinical presentation exhibits multiple, firm, and amber-colored papules that cluster to form large plaques. Histologically, there are masses of amorphous, eosinophilic material expanding the papillary dermis, and at times extending into the mid-dermis, with adjacent solar elastosis. Read More
Adv Biomed Res 2013 6;2:28. Epub 2013 Mar 6.
Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Colloid milium is a rare cutaneous condition with at least three distinct subtypes, characterized clinically by the development of yellowish translucent papules or plaques on sun-exposed skin, and histologically by the presence of colloid in the dermal papillae. In this case report, we present a man with multiple small papules on dorsum of his hands that in pathology confirmed to be colloid milium. Colloid milium is more commonly observed in fair-skin patients and remain unchanged; however our patient had dark skin type (Fitzpatrick skin type III) and lesions were increasing in summer and decreasing in winter. Read More
J Eur Acad Dermatol Venereol 2013 Feb 5;27(2):262-3. Epub 2012 Mar 5.
Int J Dermatol 2013 Jun 10;52(6):767-9. Epub 2012 Jan 10.
Int J Dermatol 2011 Dec;50(12):1531-4
Pinkus Dermatopathology Laboratory, Monroe, MI 48161, USA.
Am J Dermatopathol 2012 Feb;34(1):35-40
Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
Certain abnormal products of human tissues are resistant to degradation. The fibrillary ultrastructure of some of these are seen integrated with normal tissue components. The accumulations seen in colloid milium, lichen, and macular amyloidosis are of this type. Read More
Eur J Dermatol 2011 Nov-Dec;21(6):1023-4
Dermatol Online J 2011 Mar 15;17(3). Epub 2011 Mar 15.
Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
We report a case of a 31-year-old man with asymptomatic papules on one side of his face that had been present for 31 months. On physical examination, he had clusters of 1 to 4 mm skin colored translucent and dome-shaped, papules forming a plaque with a size of 4 x 3 cm on his left mandibular angle. Histopathology revealed atrophy of the epidermis with extensive deposition of pale eosinophilic homogenous deposits containing artifactual fissures that were PAS positive, diastase resistant, and Congo red negative. Read More
J Am Acad Dermatol 2011 Jan;64(1):203-6
Dermatol Surg 2009 Oct 20;35(10):1445-61. Epub 2009 Jul 20.
Laser and Skin Surgery Center of Indiana, Carmel, Indiana 46032, USA.
Background: Fractional photothermolysis (FP) is one of the most significant milestones in laser technology and resurfacing.
Methods: Review of the Medline English literature and recent international conferences regarding FP technology, applications, and indications.
Results: Successful conditions treated with nonablative FP reported in the literature include acne scarring; dyschromia and fine wrinkling of photoaging on the face, chest, neck, and hands; melasma; poikiloderma of Civatte; nevus of Ota; scars; minocycline hyperpigmentation; telangiectatic matting; residual hemangioma; granuloma annulare; colloid milium; and disseminated superficial actinic porokeratosis. Read More
Ann Dermatol Venereol 2009 May;136 Suppl 4:S152-9
Université Victor Segalen Bordeaux 2, 101, boulevard Wilson, 33200 Bordeaux.
In esthetic dermatology, filling and laser treatments are two essential techniques. Several recent studies on calcium hydroxyapatite in filling treatments and facial volumetry, in esthetics, but also in HIV patients, have been published. It was also tested in accentuated melomental folds where it is superior to hyaluronic acid. Read More
Am J Dermatopathol 2009 Jul;31(5):472-4
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Nodular amyloidosis is a primary cutaneous amyloidosis characterized by the deposition of amyloid L-type fibril proteins in the dermis. Clinical history and routine histology may not be sufficient to differentiate nodular amyloidosis from colloid milium. We present a case of a 45-year-old man with nodular amyloidosis, whose diagnosis was confirmed by the characteristic appearance of filaments on electron microscopy. Read More
J Pak Med Assoc 2008 Apr;58(4):207-9
Department of Dermatology, Military Hospital, Rawalpindi, Pakistan.
Colloid milium is a rare degenerative skin disorder known by the development of small translucent, yellowish brown pappular nodules or plaques, generally located in sun exposed areas. Clinically they are of two types, adult and juvenile type. We present a case of adult type Colloid milium in a 60 years old female patient with clinical and histological findings unmistakable of the condition. Read More
J Cutan Pathol 2008 Jun;35(6):566-9
Department of Pathology and Laboratory Medicine, Pathology Section, Parma University, Parma, Italy.
Colloid milium (CM) is a rare cutaneous condition characterized by translucent papules occurring on sun-exposed regions including the face, neck and dorsal aspects of the hands and back. Clinically, there are two variants of CM: an adult-onset type and a juvenile form. The juvenile form is inherited and presents before puberty. Read More
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 Apr;105(4):e34-8
Department of Dental Diagnostic Sciences, College of Dentistry, University of Detroit Mercy, Detroit, MI 48221, USA.
Colloid milium (CM) is a rare condition characterized by the presence of multiple dome-shaped amber- or flesh-colored papules developing on sun-exposed skin. It is a degenerative condition linked to excessive sun exposure and possibly exposure to petroleum products and hydroquinone. The origin of the colloid deposition in the dermis is uncertain, although it is thought to be due to degeneration of elastic fibers. Read More
Arch Dermatol 2007 May;143(5):572-4
David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.
J Drugs Dermatol 2007 Mar;6(3):293-6
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Colloid milium (CM) is a rare cutaneous deposition disease with at least 3 distinct subtypes. The exact histogenesis of the condition is still unresolved and awaits definitive elucidation. Electron microscopy and immunohistochemical analysis have allowed the distinction of CM from clinically similar conditions such as amyloidosis. Read More
J Eur Acad Dermatol Venereol 2006 Nov;20(10):1368
J Cutan Pathol 2006 Oct;33(10):679-85
Department of Pathology, University of South Florida College of Medicine, Florida, USA.
Aims: The differential diagnosis of acral keratoses is broad. Encompassing a variety of infectious, heritable and degenerative disorders, emphasis upon the clinical setting and histologic subtlety are often required to arrive at the correct diagnosis. Herein, we report on a series of adult patients who presented with agminated or solitary papules of the distal finger found on histologic examination to contain amorphous eosinophilic deposits. Read More
Arch Dermatol 2006 Jun;142(6):784-5
J Dermatol 2006 Apr;33(4):287-90
Ministry of Health, Ankara Numune Education and Research Hospital, 2nd Dermatology Clinic, Ankara, Turkey.
Colloid milium is a rare cutaneous deposition disorder that frequently occurs in areas of chronic sun exposure such as the face, neck and backs of the hands and is characterized by multiple small, discrete, usually amber-colored, dome-shaped papules that cluster to form large plaques. A 50-year-old white woman with esophageal squamous cell carcinoma was referred to us with asymptomatic, slowly spreading lesions localized to the dorsa of her hands which had been present for 4 years. The condition was diagnosed histopathologically as pigmented colloid milium associated with exogenous ochronosis (EO). Read More
Australas J Dermatol 2006 May;47(2):137-8
Davies Campbell de Lambert Pathology, Rhodes, New South Wales, Australia.
A 59-year-old woman presented with multiple translucent papules on the inner surface of the tragus of the right ear. Initially they were treated with cryotherapy, with a later biopsy revealing the diagnosis of colloid milium. The histology was unusual for adult colloid milium as the lesion lacked a Grenz zone and evidence of solar elastosis. Read More
Eur J Dermatol 2006 Mar-Apr;16(2):163-6
University Hospital of Zurich, Department of Dermatology, Gloriastrasse 31, 8091 Zurich, Switzerland.
We report the case of a 50-year-old woman with multiple soft papules in the perioral region resistant to local corticosteroid and antibiotic therapies. Histology revealed elastosis colloidalis conglomerata. There were no hints for a deposition disease. Read More
Actas Dermosifiliogr 2005 Dec;96(10):674-6
Unidad de Dermatología, Hospital Infanta Cristina, Complejo Hospitalario Universitario de Badajoz, Spain.
Colloid milium is a degenerative process that is characterized clinically by the development of translucent, yellow, 1-2 mm papules located in photoexposed areas. Histologically, deposits of a colloid substance are seen in the papillary dermis. We present two cases of this infrequent pathology in two male patients, who had been subjected to intense sun exposure because of their work. Read More
J Eur Acad Dermatol Venereol 2005 May;19(3):355-6
Department of Dermatology, Sisli Etfal Research and Teaching Hospital, Besiktas/Istanbul, Turkey.
Juvenile colloid milium is extremely rare, has its onset before puberty, may be inherited, may be caused by ultraviolet light, and is thought to result from the degeneration of keratinocytes. We report a 7-year-old girl with juvenile colloid milium. To the best of our knowledge this is the first reported case in Turkey. Read More
J Eur Acad Dermatol Venereol 2005 May;19(3):348-51
Department of Dermatology, Duzce Medical School, Abant Izzet Baysal University, 81620 Konuralp-Duzce, Turkey.
The exact nature of amyloid-like hyaline material deposits in the skin is not well understood in some disorders. Three of those--ligneous conjunctivitis, ligneous periodontitis and colloid milium--have been rarely reported in a same patient. We report a case of mucosal and skin deposits of an amyloid-like homogeneous material associated with non-Hodgkin's lymphoma and congenital auricular hypoplasia. Read More
J Am Acad Dermatol 2003 Dec;49(6):1185-8
Department of Dermatology, Ankara University Faculty of Medicine, Oran 06450 Ankara, Turkey.
Juvenile colloid milium is an uncommon cutaneous disease characterized by translucent papules distributed on sun-exposed areas with early onset. Association of juvenile colloid milium with conjunctival and gingival deposits is uncommon and interesting. We report a case of juvenile colloid milium associated with conjunctival and gingivai deposits of an amyloid-like homogeneous eosinophilic material. Read More
Surv Ophthalmol 2003 Jul-Aug;48(4):369-88
Department of Pediatrics, Leipzig University Medical School, Leipzig, Germany.
Ligneous conjunctivitis (McKusick 217090) is a rare form of chronic conjunctivitis characterized by the development of firm fibrin-rich, woody-like pseudomembraneous lesions mainly on the tarsal conjunctivae. Less frequently, similar lesions may occur on other mucous membranes of the body indicating that these manifestations are part of a systemic disease. Histopathological findings from affected humans and (plasminogen-deficient) mice indicate that wound healing, mainly of injured mucosal tissue, is impaired due to markedly decreased (plasmin-mediated) extracellular fibrinolysis. Read More
Ann Dermatol Venereol 2002 Dec;129(12):1386-8
Service de Dermatologie, CHU Farhat Hached, 4002 Sousse, Tunisie.
Introduction: Colloid Milium is a rare disease. It is characterized by the development, on sun-exposed areas, of clusters of yellow and translucid, hard papules, that seeps a gelatinous substance when opened. This dermatitis predominantly affects elderly patients and, exceptionally, children. Read More
Int J Dermatol 2002 Dec;41(12):936-8
Gaziantep University Medical Faculty, Research and Application Hospital, Gaziantep, Turkey.
Ophthalmology 2002 Oct;109(10):1944-6
Department of Ophthalmology, Combined Military Hospital, Kohat Cantonment, NWFP, Pakistan.
Aim: To report a rare presentation of colloid milium occurring only on the upper eyelid margins.
Design: Interventional case report.
Methods: (1) Slit-lamp examination of eyelids and eyes and clinical examination including the face and a general physical examination; (2) photography of the lesions on the lids; and (3) excision biopsy and histopathologic examination. Read More
Dermatol Surg 2002 Aug;28(8):780
Dermatol Surg 2002 Mar;28(3):215-9
Division of Dermatology, Penn State College of Medicine, Milton Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Background: Adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure, especially the face and dorsal hands. Attempts to remove these lesions are generally unsuccessful, but dermabrasion has been reported to be effective.
Objective: To present an effective therapeutic alternative to dermabrasion for facial colloid milium. Read More
J Am Acad Dermatol 2002 Feb;46(2 Suppl Case Reports):S5-7
Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.
We describe a case of colloid milium limited to the left arm. To the best of our knowledge, only 2 other cases of unilateral colloid milium have been reported. All of these patients had occupational UV light exposure patterns that could account for this unique distribution. Read More
Br J Dermatol 2000 Oct;143(4):884-7
Istituto San Gallicano, IRCCS, Via San Gallicano 25/a, Rome, Italy.
We report a case of adult colloid milium in a 47-year-old mechanic with a long history of professional contact with lubricating oils and of sun exposure. In addition to the typical translucent papules seen on the forehead, there were warty papules on the backs of both hands with unusual histological and ultrastructural features: marked hyperplasia of the epidermis with orthokeratotic hyperkeratosis and papillary deposits of colloid material that were contiguous with the basal layer of the epidermis. The hand lesions caused by occupational exposure to mineral oils and solar radiation represent an occupational variant of adult colloid milium. Read More
J Dermatol 2000 Jul;27(7):425-33
Department of Dermatology & Syphilogy, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Two cases of non-familial, late onset (50 and 62-years-old) hyalinosis cutis et mucosae were studied and compared with classical early onset cases. Late onset cases showed essentially the same histological and ultrastructural features described for early onset cases. The late onset variety should be distinguished from other diseases; they resemble systemic amyloidosis and sometimes the adult form of colloid milium. Read More
Cutis 2000 Jul;66(1):81-3
I report two typical cases of a cutaneous disorder caused by sunlight, which is common in Phoenix, Arizona, "The Valley of the Sun." It currently masquerades under the misnomer, adult colloid milium. It generally presents clinically as asymptomatic, shiny, smooth, firm papules, 1 to 10 mm in diameter, involving chronically sun-damaged skin of adults. Read More
Clin Exp Dermatol 2000 Mar;25(2):138-40
Department of Dermatology, Singleton Hospital, Swansea, UK.
Juvenile colloid milium is an extremely rare skin condition with an onset prior to puberty; it can be distinguished histologically from the adult form. We report a case of juvenile colloid milium associated with ligneous conjunctivitis and gingival deposits of an amyloid-like homogenous eosinophilic material. We hypothesize that all three of these are the same pathological process occurring at different sites and review the literature on these associations. Read More