7,164 results match your criteria Collegium Antropologicum [Journal]


Primary and Secondary Bacteremia Caused by spp.: Epidemiology, Strains Susceptibility and Biofilm Formation.

Pol J Microbiol 2018 ;67(4):471-478

Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz , Poland.

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of Proteus spp. Read More

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January 2018

TP53 somatic mutations are associated with somatic mitogenome substitutions but not indels in colorectal cancer cells.

J Gene Med 2018 Dec 10:e3063. Epub 2018 Dec 10.

Division of Molecular and Forensic Genetics, Department of Forensic Medicine, Faculty of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Background: p53 is a tumour suppressor protein that is involved in many cancer-related processes. Growing evidence suggests that p53 also plays an important role in mtDNA maintenance. Somatic mitogenome mutations are frequently observed in colorectal cancer cells. Read More

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December 2018

A survey on incidence and management of adenovirus infection after allogeneic HSCT.

Bone Marrow Transplant 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Hematology and Oncology, University Hospital, Collegium Medicum UMK, Bydgoszcz, Poland.

To determine the current practices on the management of Adenovirus (ADV) infection after allogenic stem cell transplantation, a survey was undertook among EBMT centres. The response rate was 20% (91/446): 46% were adult, 44% were paediatric and 10% were mixed centres, respectively. The overall incidence of ADV infection was 7. Read More

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December 2018

Morphometric study of the primary ossification center of the fibular shaft in the human fetus.

Surg Radiol Anat 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology and Oncology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.

Purposes: Precise morphometric data on the development of ossification centers in human fetuses may be useful in the early detection of skeletal dysplasias associated with delayed ossification center development and mineralization. The present study was performed to quantitatively examine the primary ossification center of the fibular shaft with respect to its linear, planar and volumetric parameters.

Materials And Methods: Using methods of CT, digital-image analysis (Osirix 3. Read More

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December 2018

Prognostic and Predictive Epigenetic Biomarkers in Oncology.

Mol Diagn Ther 2018 Dec 6. Epub 2018 Dec 6.

Molecular Oncology and Genetics Department, Innovative Medical Forum, The F. Lukaszczyk Oncology Center, Bydgoszcz, Poland.

Epigenetic patterns, such as DNA methylation, histone modifications, and non-coding RNAs, can be both driver factors and characteristic features of certain malignancies. Aberrant DNA methylation can lead to silencing of crucial tumor suppressor genes or upregulation of oncogene expression. Histone modifications and chromatin spatial organization, which affect transcription, regulation of gene expression, DNA repair, and replication, have been associated with multiple tumors. Read More

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December 2018

Sera of patients with axial spondyloarthritis (axSpA) enhance osteoclastogenic potential of monocytes isolated from healthy individuals.

BMC Musculoskelet Disord 2018 Dec 6;19(1):434. Epub 2018 Dec 6.

Department of Clinical Immunology, Institute of Paediatrics, Jagiellonian University Medical College, 265 Wielicka Str., 30-663, Krakow, Poland.

Background: Axial spondyloarthritis (axSpA) is characterized by significant bone loss caused by dysregulation of physiological bone turnover, possibly resulting from intensified differentiation of osteoclasts. The aim of this study was to reevaluate the levels of osteoclastogenesis-mediating factors: soluble RANKL, M-CSF, OPG and other cytokines in sera of untreated, with sDMARDs and/or bDMARDs, axSpA patients and to test whether these sera influence differentiation of healthy monocytes towards osteoclast lineage.

Methods: Bone remodeling molecules (RANKL, M-CSF, OPG, IL-6, OSM, IL-17A, TGFβ, and TNFα) were evaluated in 27 patients with axSpA and 23 age and sex-matched controls. Read More

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December 2018

Redefining the practical utility of blood transcriptome biomarkers in inflammatory bowel diseases.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Genetics, Maria Sklodowska-Curie Institute - Oncology Centre, Warsaw, Poland.

Background And Aims: The study investigates the practical utility of whole blood gene expression profiling to diagnose inflammatory bowel diseases (IBDs).

Methods: The discovery cohorts included 102 and 51 pediatric IBD patients and controls, and 95 and 46 adult IBD patients and controls, respectively. The replication cohorts included 447 and 76 pediatric IBD patients and controls, and 271 and 108 adult IBD patients and controls, respectively. Read More

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December 2018
1 Read

The effect of piperlongumine on endothelial and lung adenocarcinoma cells with regulated expression of profilin-1.

Onco Targets Ther 2018 22;11:8275-8292. Epub 2018 Nov 22.

Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland,

Purpose: The aim of the study was to evaluate the effect of piperlongumine (2 and 4 µM) on endothelial EA.hy926 and lung adenocarcinoma A549 cells with regulated expression of profilin-1 (PFN1).

Material And Methods: The cytotoxicity of alkaloid was evaluated by MTT assay, while cell death was assessed using double staining with annexin V and propidium iodide. Read More

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November 2018

Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane.

Oncol Rep 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Pathomorphology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz 85‑094, Poland.

Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family. The chemotherapeutic and anti‑cancerogenic capacities of SFN have been demonstrated by inhibition of cancer cell proliferation in several cancer cell lines. The aim of the present study was to evaluate the effect of SFN on apoptosis, cell cycle and expression of selected cell cycle‑associated proteins: Cyclin B1, cyclin D1 and cyclin K in the H1299 cell line. Read More

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December 2018
1 Read

Elastography in prostate gland imaging and prostate cancer detection.

Med Ultrason 2018 Dec;20(4):515-523

Chair of Urology, Department of General and Oncologic Urology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland. Department of General and Oncologic Urology, Nicolaus Copernicus Hospital, Toruń, Poland.

Transrectal prostate biopsies under ultrasonography guidance remain the gold standard for the detection of prostate cancer (PCa). Transrectal ultrasonography (TRUS), however, has a limited sensitivity in PCa detection. Prostate elastography (TRES) increases the sensitivity of a TRUS examination. Read More

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December 2018

[New possibilities for the newborn's protection against vertical HBV trasmission - a case report].

Pol Merkur Lekarski 2018 Nov;45(269):192-194

Tadeusz Browicz Hospital of Infectious Diseases, Bydgoszcz, Poland.

The patient was diagnosed with chronic hepatitis B at 19 years old. Biochemical, serological and histopathological diagnostic processes were followed by pegylated interferon treatment. After 24 weeks of therapy treatment was discontinued due to pathological thyroid hormones values. Read More

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November 2018

Safety of intrathecal injection of Wharton's jelly-derived mesenchymal stem cells in amyotrophic lateral sclerosis therapy.

Neural Regen Res 2019 Feb;14(2):313-318

Department of Neurology and Neurosurgery, School of Medicine, Collegium Medicum - University of Warmia and Mazury in Olsztyn; University Clinical Hospital in Olsztyn, Olsztyn, Poland.

Animal experiments have confirmed that mesenchymal stem cells can inhibit motor neuron apoptosis and inflammatory factor expression and increase neurotrophic factor expression. Therefore, mesenchymal stem cells have been shown to exhibit prospects in the treatment of amyotrophic lateral sclerosis. However, the safety of their clinical application needs to be validated. Read More

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February 2019

Rheological parameters of saliva in comparison with taste examination.

Biorheology 2018 ;55(1):51-60

Chair and Clinic of Conservative Dentistry and Periodontology, University of Medical Sciences, Collegium Stomatologicum, Bukowska 70, Poznań, Poland.

Background: It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry. Read More

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January 2018

Are TNC gene variants associated with anterior cruciate ligament rupture susceptibility?

J Sci Med Sport 2018 Oct 17. Epub 2018 Oct 17.

Faculty of Physical Education, Gdansk University of Physical Education and Sport, Poland.

Objectives: To investigate the role of inter-individual variations in a particular glycoprotein, TNC, and its potential contribution to anterior cruciate ligament (ACL) injury susceptibility in Polish Caucasian participants. ACL rupture is one of the most prevalent and severe knee injury that predominantly occurs during sports participation, primarily via a non-contact mechanism. Several polymorphisms in genes encoding glycoproteins either independently or as allelic combinations, modulate the risk of musculoskeletal soft tissue injuries. Read More

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October 2018

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
3 Reads

Application of amniotic membrane in reconstructive urology; the promising biomaterial worth further investigation.

Expert Opin Biol Ther 2018 Dec 6. Epub 2018 Dec 6.

e Chair of Urology, Department of Regenerative Medicine, Collegium Medicum , Nicolaus Copernicus University , Bydgoszcz , Poland ;

Introduction: In reconstructive urology, autologous tissues such as intestinal segments, skin, and oral mucosa are used. Due to their limitations, reconstructive urologists are waiting for a novel material, which would be suitable for urinary tract wall replacement. Human amniotic membrane (AM) is a naturally derived biomaterial with a capacity to support reepithelization and inhibit scar formation. Read More

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December 2018
4 Reads

Fatty acids and selected endocannabinoids content in cerebrospinal fluids from patients with neuroinfections.

Metab Brain Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, Krakow, Poland.

Neuroinfections are a significant medical problem and can have serious health consequences for patients. Their outcome, if not fatal, can be associated with permanent residual deficits. Cerebrospinal fluid (CSF) examination is commonly used for meningitis confirmation. Read More

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December 2018
5 Reads

Impact of opioid dose reduction on individuals with chronic pain: results of an online survey.

J Pain Res 2018 8;11:2769-2779. Epub 2018 Nov 8.

Collegium Pharmaceutical Inc., Canton, MA, USA.

Background: In 2016, the Centers for Disease Control and Prevention (CDC) released a guideline on opioid prescribing for primary care physicians. Patients with chronic pain receiving long-term opioid therapy were surveyed to assess the incidence and impact of opioid dose reduction following this guideline's promulgation.

Methods: Members of an advocacy organization for people with chronic pain were invited to participate in a 16-item, anonymous, online survey conducted in September/October 2017. Read More

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November 2018
5 Reads

Has the quality of physiotherapy care in patients with Whiplash-associated disorders (WAD) improved over time? A retrospective study using routinely collected data and quality indicators.

Patient Prefer Adherence 2018 8;12:2291-2308. Epub 2018 Nov 8.

Department of Medical Psychology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.

Purpose: To develop valid quality indicators (QIs) for physiotherapy care based on best available evidence, and to use these QIs to explore trends in the quality of physiotherapy care of patients with Whiplash-associated disorders (WAD) using guideline-based routinely collected data (RCD) gathered between 1996 and 2011.

Materials And Methods: The study consisted of two phases: 1) development of QIs and 2) analysis of patient records. A set of QIs was developed based on recommendations in the scientific literature and the Dutch Clinical Practice Guideline (CPG) "Physiotherapy Management and WAD". Read More

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November 2018
3 Reads

Decreased Bioelectrical Impedance Phase Angle in Hospitalized Children and Adolescents with Newly Diagnosed Type 1 Diabetes: A Case-Control Study.

J Clin Med 2018 Dec 4;7(12). Epub 2018 Dec 4.

Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszów, 35-959 Rzeszów, Poland.

The aim of this study was to assess the body composition and nutritional status of hospitalized pediatric patients with newly diagnosed type 1 diabetes by using bioelectrical impedance analysis (BIA) with phase angle (PA) calculation. PA is considered to be a useful and very sensitive indicator of the nutritional and functional status, and it has not yet been evaluated in such a population. Sixty-three pediatric patients aged 4 to 18 years, with newly diagnosed type 1 diabetes, were included in the study. Read More

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December 2018
1 Read

An analysis of the influence of infection on overall survival rates, following modified posterior pelvic exenteration for advanced ovarian cancer.

Ginekol Pol 2018 ;89(11):618-626

Clinical Department of Gynecological Oncology, Professor Franciszek Lukaszczyk Oncology Center, Bydgoszcz, Poland; Department of Oncology, Radiotherapy and Oncological Gynecology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Objectives The aim of our study has been to determine the association between the appearance of infection after modified posterior pelvic exenteration (MPE) and TTC (time to adjuvant chemotherapy) and to examine whether the infection impacts clinical results by delaying the start of chemotherapy. Material and methods The present, retrospective study analyzed 77 patients who had undergone MPE followed by adjuvant chemotherapy. Either no residual tumor or tumor less than 2. Read More

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January 2018
1 Read

Sleep disorders in patients with psoriatic arthritis and psoriasis.

Reumatologia 2018 31;56(5):301-306. Epub 2018 Oct 31.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Poland.

Objectives: To assess and measure occurrence of sleep disorders in patients with psoriatic arthritis (PsA) and psoriasis (Ps).

Material And Methods: The study included 62 patients with psoriatic arthritis and 52 patients with psoriasis. The measurement of sleep quality was conducted using the Pittsburgh Sleep Quality Index (PSQI), the evaluation of fatigue by the fatigue subscale of the FACIT-F questionnaire and the patient's quality of life by the Health Assessment Questionnaire (HAQ). Read More

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October 2018
1 Read

Application of epineural sheath conduit for restoration of 6-cm long nerve defects in a sheep median nerve model.

Microsurgery 2018 Dec 4. Epub 2018 Dec 4.

Department of Plastic Surgery, Cleveland Clinic, Cleveland, Ohio.

Background: Due to limited number of studies, we tested feasibility of autologous epineural sheath conduit (ESC) in repair of 6-cm median nerve gaps in a sheep-the large animal model.

Materials And Methods: Eight ewes, 6-8 months old, 30-35 kg, were divided into three experimental groups: group 1-no defect repair (n = 4 nerves/group), group 2-autograft controls (n = 6 nerves/group), group 3-autologous ESC filled with saline (n = 6 nerves/group). ESC was constructed from a 6-cm long segment of sheep median nerve and tested for expression of laminin B, Glial fibrillary acidic protein (GFAP), S-100 and CD31 using immunofluorescent staining. Read More

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December 2018

Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus.

Oxid Med Cell Longev 2018 28;2018:1439575. Epub 2018 Oct 28.

Institute of Physical Education, Kazimierz Wielki University in Bydgoszcz, Poland.

Background: Tinnitus is defined as a phantom auditory perception, i.e., sound experience despite the lack of acoustic stimuli in the environment. Read More

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October 2018
1 Read

Quality evaluation of smartphone applications for laboratory medicine.

Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.

c/o European Federation of Clinical Chemistry and Laboratory Medicine, Milan, Italy.

Background Many of the mobile applications (apps) used for delivering health interventions involve laboratory medicine data. This survey was conducted to search the online market for health apps that manage laboratory medicine data. The aim was to review them and perform a quality evaluation. Read More

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November 2018
2 Reads

FDG PET/CT as a survival prognostic factor in patients with advanced renal cell carcinoma.

Clin Exp Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.

Accurate prediction of the outcome of molecular target-based treatment in advanced renal cell carcinoma (RCC) is an important clinical problem. Positron emission tomography/computed tomography using [18F]-2-fluoro-2-deoxyglucose (FDG PET/CT) is a noninvasive tool for the assessment of glucose accumulation which can be a marker of the biological characteristics of the tumor. In this paper, we assess FDG PET/CT as a survival prognostic marker in patients with advanced RCC. Read More

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November 2018
4 Reads

Low frequency electromagnetic waves increase human sperm motility - A pilot study revealing the potent effect of 43 khz radiation.

Int J Occup Med Environ Health 2018 Nov 28. Epub 2018 Nov 28.

Institute of Rural Health, Lublin, Poland (Department for Health Problems of Aging).

Objectives: Abnormalities in the timing and course of spermatozoa capacitation and hyperactivation underlie common pathologies related to male infertility. Recent data shows that low frequency electromagnetic waves may influence cell membrane potential and permeability. It is therefore possible that low frequency electromagnetic waves could affect the maturation and motility processes of spermatozoa. Read More

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November 2018
2 Reads

Kinetics of selected serum markers of fibrosis in patients with dilated cardiomyopathy and different grades of diastolic dysfunction of the left ventricle.

Cardiol J 2018 Nov 28. Epub 2018 Nov 28.

Collegium Medicum of Jagiellonian University, Department of Cardiac and Vascular Diseases, John Paul II Hospital, Kraków, Poland, ul.Prądnicka 80, 31-202 Cracow, Poland.

Background: Fibrosis of the extracellular matrix (ECM) in dilated cardiomyopathy (DCM) is common and compromises both systolic and diastolic function. The aim of this study was to investigate the kinetics of ECM fibrosis markers over a 12 month follow-up in patients with DCM based on the severity of diastolic dysfunction (DD).

Methods: Seventy consecutive DCM patients (48 ± 12. Read More

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November 2018
1 Read

Caries detection enhancement using texture feature maps of intraoral radiographs.

Oral Radiol 2018 Nov 9. Epub 2018 Nov 9.

Department of Geoinformatics and Applied Computer Science, AGH University of Science and Technology, Mickiewicza 30, 30-059, Cracow, Poland.

Objectives: Dental caries are caused by tooth demineralization due to bacterial plaque formation. However, the resulting lesions are often discrete and thus barely recognizable in intraoral radiography images. Therefore, more advanced detection techniques are in great demand among dentists and radiographers. Read More

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November 2018
3 Reads

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 Dec 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Read More

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December 2018
6 Reads

A systematic review and meta-analysis of the Kwak TIRADS for the diagnostic assessment of indeterminate thyroid nodules.

Clin Radiol 2018 Oct 25. Epub 2018 Oct 25.

Civis-Vita Health and Medical Centre, Warszawska 20, 87-100 Torun, Poland.

Aim: To explore the diagnostic usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) classification proposed by Kwak in indeterminate nodules using a systematic literature review.

Material And Methods: The PubMed, Cochrane database, ScienceDirect, and EMBASE databases were searched for relevant articles. A meta-analysis was performed to calculate pooled sensitivity, specificity, negative and positive likelihood ratios (LR- and LR+), diagnostic odds ratio (DOR), and area under the curve (AUC) from summarised receiver operating characteristic (SROC) curves. Read More

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October 2018

Celiac ganglia: can they be misinterpreted on multimodal 68Ga-PSMA-11 PET/MR?

Nucl Med Commun 2018 Nov 14. Epub 2018 Nov 14.

Department of Nuclear Medicine, The Franciszek Lukaszczyk Oncology Centre.

Objective: The objective of this study was to investigate the morphologic features and Ga-prostate-specific membrane antigen (PSMA)-11 avidity of celiac ganglia (CG) on multimodal PET/MRI.

Materials And Methods: Ga-PSMA-11 whole-body PET/MR examinations in 120 patients, referred for staging or follow-up of prostate cancer, were retrospectively reviewed to investigate the radiotracer uptake [maximum standardized uptake value (SUVmax)] and morphologic features (size, shape, location) of CG. Nodular, oval and longitudinal nodular, thick or with oval parts shapes of CG were regarded as mistakable with lymph nodes, whereas linear and longitudinal shapes were considered as not mistakable. Read More

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November 2018
4 Reads

The analysis of the long-term outcomes in elderly women treated for locally advanced cervical cancer.

J Contemp Brachytherapy 2018 Oct 31;10(5):411-417. Epub 2018 Oct 31.

Department of Oncology, Radiotherapy and Oncological Gynecology, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz.

Purpose: Locally advanced cervical cancer (LACC) should be treated with a combination of external irradiation and brachytherapy with concurrent chemotherapy. However, as cervical carcinoma cells can disperse by way of the lymphatic system to either pelvic or para-aortic nodes, planning the extent of radiation requires precise information about the spread of the disease to the lymph nodes, especially to the para-aortic area.

Material And Methods: All of the 75 women included in our study underwent chemoradiotherapy, which started with brachytherapy. Read More

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October 2018
1 Read

An application of QSRR approach and multiple linear regression method for lipophilicity assessment of flavonoids.

J Pharm Biomed Anal 2018 Nov 16;164:681-689. Epub 2018 Nov 16.

Department of Biopharmacy, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Jurasza 2, 85-089, Bydgoszcz, Poland.

The analysis of quantitative structure-retention relationships (QSRR) is useful tool for assessment of compound's lipophilicity/hydrophobicity due to similarity between its retention in chromatographic system and ability to permeation through biological membranes. The main goal of this study was to compare usefulness of two reversed-phase chromatographic columns (Synergy POLAR and Synergy-FUSION) for lipophilicity assessment of 30 structurally diverse flavonoids using the QSRR approach and multiple linear regression method. The developed MLR models included the mechanistically interpretable geometrical descriptors: 3D Molecule Representation of Structure based on Electron diffraction (3D-MoRSE) and Radial Distribution Function (RDF). Read More

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November 2018

New heights and hot topics in Cardiovascular Research.

Cardiovasc Res 2018 Dec;114(14):e114-e119

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, UK.

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December 2018

Successful Management of Unusual Multiple Gut Colonization With Extremely Drug-resistant Bacteria in an Infant Undergoing Hematopoietic Cell Transplantation.

J Pediatr Hematol Oncol 2018 Nov 20. Epub 2018 Nov 20.

Pediatric Hematology and Oncology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, University Hospital No. 1, Bydgoszcz, Poland.

Enterobacterales represent a serious threat to transplant patients due to their increase frequency of carbapenem resistance and wide spreading. We present a case of an infant with acute lymphoblastic leukemia undergoing hematopoietic stem cell transplantation. Before transplantation an unusual double colonization of the gastrointestinal tract with extremely resistant Escherichia coli and Klebsiella pneumoniae strains producing metallo-beta-lactamase was diagnosed. Read More

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November 2018
1 Read

A study of biological and lifestyle factors, including within-subject variation, affecting concentrations of growth differentiation factor 15 in serum.

Clin Chem Lab Med 2018 Nov 24. Epub 2018 Nov 24.

Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.

Background Growth differentiation factor 15 (GDF-15) is an emerging cardiovascular biomarker, and a fully automated immunoassay has recently become available. The objectives of the study were to identify biological and lifestyle factors affecting serum GDF-15 concentrations and derive robust reference intervals, and to estimate GDF-15 within-subject biological variation and derived indices. Methods A presumably healthy population of 533 questionnaire-screened adults was used to identify the biological and lifestyle determinants of serum GDF-15. Read More

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November 2018

Three-dimensional growth of tibial shaft ossification in the human fetus: a digital-image and statistical analysis.

Surg Radiol Anat 2018 Nov 23. Epub 2018 Nov 23.

Department of Otolaryngology and Oncology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.

Purposes: Tibial shaft ossification in terms of its size and growth may be criticalin describing both the fetal stage and maturity, and in identifying innate disorders. The present study was executed to quantitatively assess ossification of the tibial shaft, taking its morphometric linear, planar and volumetric parameters into account.

Materials And Methods: With the use of methods of CT, digital-image analysis and statistics, the evolutionof tibial shaft ossification in 47 spontaneously aborted human fetuses at the age of 17-30 weeks was studied. Read More

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November 2018

A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet.

Nutrients 2018 Nov 21;10(11). Epub 2018 Nov 21.

Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum Faculty of Medicine, University of Warmia & Mazury, Oczapowskiego 2 Str., 10-719 Olsztyn, Poland.

Iron deficiency anemia (IDA) occurs in 15⁻46% of patients with celiac disease (CD), and in some cases, it may be its only manifestation. Studies in animal models have shown that prebiotics, including inulin, may help to increase intestinal absorption of iron. The aim of this study was to evaluate the effect of a prebiotic, oligofructose-enriched inulin (Synergy 1), on iron homeostasis in non-anemic children and adolescents with celiac disease (CD) in association with a gluten-free diet (GFD). Read More

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November 2018
1 Read

Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions.

Nutrients 2018 Nov 21;10(11). Epub 2018 Nov 21.

Department of Pathophysiology of Hearing and Balance System, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Resveratrol (RV) is a natural non-flavonoid polyphenol and phytoalexin produced by a number of plants such as peanuts, grapes, red wine and berries. Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways. Read More

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November 2018
3 Reads

Sex Differences in Social Attention in Infants at Risk for Autism.

J Autism Dev Disord 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychology, Uppsala Child and Baby Lab, Uppsala University, Box 1225, 751 42, Uppsala, Sweden.

We studied visual attention to emotional faces in 10-month-old infant siblings of children with ASD (ASD-sibs; N = 70) and a siblings of typically developing children (N = 29) using static stimuli. Contrary to our predictions, we found no evidence for atypical gaze behavior in ASD-sibs when boys and girls were analyzed together. However, a sex difference was found in ASD-sibs' visual attention to the mouth. Read More

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November 2018
1 Read

Caspase 3 as a Novel Marker to Distinguish Chromophobe Renal Cell Carcinoma from Oncocytoma.

Pathol Oncol Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. Sklodowskiej-Curie Str. 9, 85-094, Bydgoszcz, Poland.

Despite advances in our understanding of the biology of chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO), the differential diagnosis among these tumors remains one of the most problematic in renal pathology. Today, CK7 is the most recommended marker to distinguish these entities, however it appears insufficiently accurate by itself. This study aimed to find an easily accessible IHC stain that might out-compete CK7 in this field. Read More

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November 2018
3 Reads

Polyhedrocytes in blood clots of type 2 diabetic patients with high cardiovascular risk: association with glycemia, oxidative stress and platelet activation.

Cardiovasc Diabetol 2018 Nov 22;17(1):146. Epub 2018 Nov 22.

Institute of Cardiology, Jagiellonian University Medical College, Prądnicka 80 St., Kraków, Poland.

Background: Little is known about factors that affect the composition of contracted blood clots in specific diseases. We investigated the content of polyhedral erythrocytes (polyhedrocytes) formed in blood clots and its determinants in type 2 diabetes (T2D) patients.

Methods: In 97 patients with long-standing T2D [median HbA, 6. Read More

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November 2018
4 Reads

Spotting Signs of Autism in 3-Year-Olds: Comparing Information from Parents and Preschool Staff.

J Autism Dev Disord 2018 Nov 21. Epub 2018 Nov 21.

Uppsala Child and Baby Lab, Department of Psychology, Uppsala University, 751 42, Uppsala, Sweden.

Preschool informants may provide valuable information about symptoms of autism spectrum disorder (ASD) in young children. We compared the diagnostic accuracy of ratings by preschool staff with those by parents of 3-year-old children using the Achenbach System of Empirically Based Assessment Preschool Forms. The sample consisted of 32 children at familial risk for ASD without diagnosis, 10 children at risk for ASD with diagnosis, and 14 low-risk typically developing controls. Read More

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November 2018
2 Reads

Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017.

Euro Surveill 2018 Nov;23(46)

Members of the Healthcare-Associated Infections Prevalence Study Group are listed at the end of this article.

Point prevalence surveys of healthcare-associated infections (HAI) and antimicrobial use in the European Union and European Economic Area (EU/EEA) from 2016 to 2017 included 310,755 patients from 1,209 acute care hospitals (ACH) in 28 countries and 117,138 residents from 2,221 long-term care facilities (LTCF) in 23 countries. After national validation, we estimated that 6.5% (cumulative 95% confidence interval (cCI): 5. Read More

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November 2018
4 Reads

METoclopramide Administration as a Strategy to Overcome MORPHine-ticagrelOr Interaction in PatientS with Unstable Angina PectorIS-The METAMORPHOSIS Trial.

Thromb Haemost 2018 Dec 19;118(12):2126-2133. Epub 2018 Nov 19.

Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Extensive search for methods of overcoming morphine-related delay of the absorption and onset of action of oral P2Y inhibitors in patients presenting with acute coronary syndrome is on-going. The aim of the trial was to investigate whether metoclopramide co-administration could reduce this delay and improve the pharmacokinetics (PKs) and pharmacodynamics (PDs) of ticagrelor and its active metabolite AR-C124900XX. Plasma concentration of both compounds and platelet reactivity were evaluated in nine pre-defined time points within 6 hours after administration of ticagrelor loading dose. Read More

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December 2018
7 Reads

Prenatal exposures and infant brain: Review of magnetic resonance imaging studies and a population description analysis.

Hum Brain Mapp 2018 Nov 19. Epub 2018 Nov 19.

FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Turku, Finland.

Brain development is most rapid during the fetal period and the first years of life. This process can be affected by many in utero factors, such as chemical exposures and maternal health characteristics. The goal of this review is twofold: to review the most recent findings on the effects of these prenatal factors on the developing brain and to qualitatively assess how those factors were generally reported in studies on infants up to 2 years of age. Read More

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November 2018
2 Reads

Paradoxical growth effect of caspofungin on Candida spp. sessile cells not only at high drug concentrations.

J Antibiot (Tokyo) 2018 Nov 19. Epub 2018 Nov 19.

Department of Microbiology, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, 9 Maria Curie-Skłodowska Street, 85-094, Bydgoszcz, Poland.

According to the available literature, echinocandins display high anti-Candida spp. activity. Paradoxical growth (PG) of Candida spp. Read More

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November 2018
4 Reads

The state of the health of the oral cavity and health behaviors.

Wiad Lek 2018 ;71(7):1354-1359

Department Of Medical Psychology And Medical Communication, Medical University Of Warsaw, Poland.

Objective: The aim: To compare the patients' self-evaluations of oral hygiene and oral health with the results of the clinical examination expressed using both the DMFT index (DT, MT, FT) and the API index; and to evaluate the relationship between the patients' general health behaviors and their oral health status.

Patients And Methods: Material and Methods: 78 first-time dental patients (40 females, 38 males; Mage=40,7, SD=14.4) participated in the study. Read More

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January 2018
1 Read

Is obesity associated with impaired reaction time in youth?

Eat Weight Disord 2018 Nov 16. Epub 2018 Nov 16.

Department of Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.

Background And Purpose: Recent research demonstrates a significant relationship between weight status and impaired reaction time in young, adult, and elderly individuals. However, most such studies were performed on small samples, used only body mass index as the body obesity index, used simple reaction time, and oftentimes did not consider some potential confounders such as age, socioeconomic status, or physical activity in their studies. The present study explored the relationship between various reaction time tasks and various obesity indices in a sample of youth. Read More

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November 2018
6 Reads
0.680 Impact Factor