469 results match your criteria Collagenous and Lymphocytic Colitis


Microscopic colitis.

Nat Rev Dis Primers 2021 Jun 10;7(1):39. Epub 2021 Jun 10.

Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Microscopic colitis (MC) is an inflammatory disease of the large intestine associated with urgent watery diarrhoea. MC may occur in people of all ages, although the disease primarily affects older women. Once believed to be rare, MC is now known to be a common cause of chronic watery diarrhoea in high-income countries, affecting 1 in 115 women and 1 in 286 men during their lifetime in Swedish population-based estimates. Read More

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Microscopic Colitis and Risk of Colon Adenomas: A Multicenter Retrospective Cohort Study.

Clin Gastroenterol Hepatol 2021 May 29. Epub 2021 May 29.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Microscopic colitis (MC) is a common cause of chronic watery diarrhea, with the highest incidence in women over age 50. Cross-sectional studies have suggested that patients with MC have a lower incidence of adenomatous colon polyps compared with those without MC. The existing literature is limited by cross-sectional design, small sample sizes, lack of longitudinal follow-up, and the use of average-risk patients, rather than those with chronic diarrhea, as controls. Read More

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A 5-year clinicopathological study on microscopic colitis at a Malaysian tertiary hospital.

Med J Malaysia 2021 May;76(3):318-325

Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia.

Introduction: Microscopic colitis (MC) is a well-recognised cause of chronic diarrhoea in Western countries. It is classically associated with normal endoscopic findings and a higher prevalence among patients with autoimmune disease. Local information regarding this disease remains scarce. Read More

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Histological disease activity in patients with microscopic colitis is not related to clinical disease activity or long-term prognosis.

Aliment Pharmacol Ther 2021 Jul 21;54(1):43-52. Epub 2021 May 21.

Roskilde, Denmark.

Background: Microscopic colitis (MC) is a common cause of chronic watery diarrhea. Biopsies with characteristic histological features are crucial for establishing the diagnosis. The two main subtypes are collagenous colitis (CC) and lymphocytic colitis (LC) but incomplete forms exist. Read More

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Microscopic Colitis: A Concise Review for Clinicians.

Mayo Clin Proc 2021 05;96(5):1302-1308

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN. Electronic address:

Microscopic colitis (MC) is an inflammatory disease of the colon and a common cause of chronic watery diarrhea, predominantly in older patients. Microscopic colitis encompasses 2 different subtypes, lymphocytic colitis and collagenous colitis. The colon typically appears normal endoscopically in MC, and the diagnosis requires histologic evaluation. Read More

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Levodopa/dopa decarboxylase inhibitor associated microscopic colitis: An under-recognized drug reaction.

Parkinsonism Relat Disord 2021 May 20;86:84-90. Epub 2021 Apr 20.

Movement Disorder Unit, Neurology Department, Westmead Hospital, Corner Darcy and Hawkesbury Road, Westmead, NSW 2145, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Background: Microscopic colitis is a form of inflammatory bowel disease characterized by profuse non-bloody watery diarrhea. Macroscopic abnormality is not present on colonoscopy, and it requires biopsy for diagnosis. Few cases have been attributed to levodopa/dopa-decarboxylase inhibitor therapy. Read More

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Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases.

Dig Dis Sci 2021 Apr 22. Epub 2021 Apr 22.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W. Charlton Bldg., Rm. 8-110, Rochester, MN, 55905, USA.

Background: Increased fecal bile acid excretion (IBAX) occurs in a third of patients with functional diarrhea.

Aims: To assess the prevalence of IBAX in benign inflammatory intestinal and colonic diseases presenting with chronic diarrhea.

Methods: All patients with known inflammatory diseases or resections who underwent 48 h fecal fat and BA testing for chronic diarrhea at a single center were included. Read More

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Quantifying intraepithelial lymphocytes and subepithelial collagen band in microscopic colitis, extracting insights into the interrelationship of lymphocytic and collagenous colitis.

Ann Diagn Pathol 2021 Jun 31;52:151741. Epub 2021 Mar 31.

Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; Department of Medical Gastroenterology, Zealand University Hospital Koege, Lykkebækvej 1, 4600 Koege, Denmark.

Microscopic colitis (MC) is the umbrella term for the conditions termed lymphocytic colitis (LC) and collagenous colitis (CC). LC with thickening of the subepithelial collagen band or CC with increased number of intraepithelial T- lymphocytes (IELs) is often seen in MC and may lead to difficulties in correct histological classification. We investigated the extent of overlapping features of CC and LC in 60 cases of MC by measuring the exact thickness of the subepithelial collagen band in Van Gieson stained slides and quantifying number of IELs in CD3 stained slides by digital image analysis. Read More

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Collagenous gastritis: Epidemiology and clinical associations.

Dig Liver Dis 2021 Apr 3. Epub 2021 Apr 3.

Division of Gastroenterology, Portland VA Medical Center and Oregon Health and Science University, United States.

Background: the rare occurrence of collagenous gastritis (CG) makes its epidemiology difficult to investigate. We designed a study to determine the demographic and clinical characteristics as well as the associations of CG with other upper gastrointestinal diseases in a large national clinicopathological database.

Methods: from the IDEA database we extracted all patients with histopathologically documented CG and, in a case-control study, we compared 168 subjects with and 1,286,165 subjects without CG using odds ratios (OR) with their 95% confidence intervals (CI). Read More

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Histopathology of Non-IBD Colitis. A practical approach from the Italian Group for the study of the gastrointestinal tract (GIPAD).

Pathologica 2021 Feb;113(1):54-65

University Hospital "San Giovanni di Dio e Ruggi D'Aragona", Salerno, Italy.

Non-IBD colitides (NIBDC) are intestinal diseases clinically and endoscopically overlapping with Inflammatory Bowel Diseases (IBD), sometimes with a similar histological picture. NIBDC include entities such as infectious colitis, ischemic colitis, pseudomembranous colitis, eosinophilic colitis, autoimmune enterocolitis, segmental colitis associated with diverticulosis, drug-induced colitis, radiation-induced colitis, diversion colitis, and microscopic colitis, this last including two entities: collagenous and lymphocytic colitis. The knowledge of the most useful histological features and the main clinical data for each entity is mandatory in daily clinical practice, for correct pathological diagnosis and clinical management. Read More

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February 2021

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations.

United European Gastroenterol J 2021 Feb 22. Epub 2021 Feb 22.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University, Szczecin, Poland.

Introduction: Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder.

Methods: Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Read More

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February 2021

Association Between Collagenous and Lymphocytic Colitis and Risk of Severe Coronavirus Disease 2019.

Gastroenterology 2021 06 19;160(7):2585-2587.e3. Epub 2021 Feb 19.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York. Electronic address:

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Bile Acid Sequestrant Therapy in Microscopic Colitis.

J Clin Gastroenterol 2021 Jan 12. Epub 2021 Jan 12.

Division of Gastroenterology, University of Chicago Medicine, NorthShore University Health System, Evanston, IL.

Goals: There is an unmet need in investigating corticosteroid-sparing treatments for induction and maintenance of remission in microscopic colitis (MC). The authors' aim was to evaluate the outcomes of patients with MC treated with bile acid sequestrants (BAS).

Background: MC is a common chronic diarrheal illness. Read More

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January 2021

Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden.

Gastroenterology 2021 Apr 6;160(5):1599-1607.e5. Epub 2021 Jan 6.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Orebro University Hospital, Orebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.

Background And Aims: Gastrointestinal infections have been linked to changes in the composition and function of gut microbiome and development of inflammatory bowel diseases. We therefore sought to examine the relationship between gastroenteritis and risk of microscopic colitis (MC).

Methods: We conducted a case-control study of all adult patients with MC diagnosed between 1990 and 2016 in Sweden matched to up to 5 general population controls according to age, sex, calendar year, and county. Read More

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Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis.

Gastroenterol Hepatol 2020 Nov 25. Epub 2020 Nov 25.

Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Madrid, España.

Objective: To study the epidemiological and clinical characteristics, and response to treatment in patients with microscopic colitis.

Patients And Method: Epidemiological, clinical, blood test and endoscopic data were retrospectively collected from 113 patients with microscopic colitis. Response to treatment was analyzed in 104 of them. Read More

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November 2020

Collagenous colitis and atezolizumab therapy: an atypical case.

Clin J Gastroenterol 2021 Feb 5;14(1):165-169. Epub 2020 Nov 5.

Internal Medicine, UOC Clinica Medica, Fondazione Policlinico Universitario "A.Gemelli" IRCCS, Largo Gemelli, 8, 00168, Rome, Italy.

Immune checkpoint inhibitors such as anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti-PD-1 (programmed cell death protein 1), and PD-L1 (programmed cell death protein-ligand 1) are emerging drugs that have radically changed treatment and prognosis of different types of tumors. However, despite their considerable benefits, immune checkpoint inhibitors are associated with numerous side effects involving several organs. Gastrointestinal toxicities represent some of these most common adverse events. Read More

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February 2021

Overview of microscopic colitis.

Br J Hosp Med (Lond) 2020 Oct 6;81(10):1-7. Epub 2020 Oct 6.

Department of Gastroenterology, St Mark's Hospital, LNWH Trust, Harrow, UK.

Microscopic colitis encompasses both collagenous and lymphocytic colitis and is a relatively common condition with rising incidence. Diagnosis is by colonoscopy (which is usually normal but may show some mild changes) and biopsies which reveal characteristic histological findings. Symptoms include non-bloody diarrhoea with urgency which may be associated with faecal incontinence and abdominal pain. Read More

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October 2020

Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study.

Dig Liver Dis 2020 Oct 28. Epub 2020 Oct 28.

Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy. Electronic address:

Background And Aims: Microscopic colitis (MC) is the most frequent condition in subjects undergoing ileocolonoscopy for chronic non-bloody diarrhea (CNBD) in Western countries. Emerging evidence has shown a negative association between MC and colorectal cancer. Within this prospective multi-center study we have evaluated the risk of colorectal neoplasia in MC and non-MC patients with CNBD receiving ileocolonoscopy with high-definition plus virtual chromoendoscopic imaging and histopathological assessment. Read More

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October 2020

Increasing Incidence of Microscopic Colitis in a Population-Based Cohort Study in Switzerland.

Clin Gastroenterol Hepatol 2020 Oct 14. Epub 2020 Oct 14.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Electronic address:

Microscopic colitis (MC) is a chronic inflammatory disease of the colon that presents with chronic, nonbloody watery diarrhea and only few or no endoscopic abnormalities. Histologic examination discriminates lymphocytic colitis (LyC; presence of ≥20 intraepithelial lymphocytes per 100 surface epithelial cells) and collagenous colitis (CC; colonic subepithelial collagen band >10 μm in diameter). MC not otherwise specified describes a subgroup of patients who do not fulfill the diagnostic criteria for either CC or LyC. Read More

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October 2020

Microscopic Colitis Is Not an Independent Risk Factor for Low Bone Density.

Dig Dis Sci 2020 Oct 15. Epub 2020 Oct 15.

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, USA.

Background: Microscopic colitis (MC) is a subtype of inflammatory bowel disease (IBD) with overlapping risk factors for low bone density (LBD). While LBD is a known complication of IBD, its association with MC is not well-established.

Aims: Assess the prevalence of LBD in MC compared to control populations, and evaluate if MC predicts LBD when controlling for confounders. Read More

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October 2020

Disease Activity Patterns, Mortality, and Colorectal Cancer Risk in Microscopic Colitis: A Danish Nationwide Cohort Study, 2001 to 2016.

J Crohns Colitis 2021 Apr;15(4):594-602

Department of Gastroenterology, North Zealand University Hospital, Capital Region, Denmark.

Background And Aims: The disease course of microscopic colitis [MC], encompassing collagenous colitis [CC] and lymphocytic colitis [LC], is not well known. In a Danish nationwide cohort, we evaluated the disease activity patterns as well as the risk of colorectal cancer [CRC] and mortality based on disease severity.

Methods: All incident MC patients [n = 14 302] with a recorded diagnosis of CC [n = 8437] or LC [n = 5865] in the Danish Pathology Register, entered between 2001 and 2016, were matched to 10 reference individuals [n = 142 481]. Read More

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Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up.

Hum Pathol 2020 12 28;106:13-22. Epub 2020 Sep 28.

Department of Pathology and Laboratory Medicine, The Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, 21287, USA. Electronic address:

Microscopic colitis (MC) is characterized by chronic watery diarrhea, endoscopically normal findings, and abnormal histology. While mostly encountered in adults, pediatric cases are rare and may show varying presentations. Our pathology data system was searched from 1984 to 2019 for patients ≤18 years of age with a lymphocytic colitis (LC) or collagenous colitis (CC) pattern of injury. Read More

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December 2020

Medication-specific variations in morphological patterns of injury in immune check-point inhibitor-associated colitis.

Histopathology 2021 Mar 22;78(4):532-541. Epub 2020 Nov 22.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Aims: A varied spectrum of histopathological changes has been associated with immune checkpoint inhibitor (ICI) colitis. This study was performed to evaluate the prevalence of different histopathological patterns of injury in patients with ICI colitis and their association with specific immune check-point inhibitors.

Methods And Results: Biopsies from patients with clinically and histologically confirmed ICI colitis were reviewed blindly to determine the predominant pattern of injury and to quantitate discrete histological parameters using the Geboes score. Read More

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Distribution of histopathological features along the colon in microscopic colitis.

Int J Colorectal Dis 2021 Jan 12;36(1):151-159. Epub 2020 Sep 12.

Gastroenterology and Hepatology in Linköping, and Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.

Purpose: The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon. Read More

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January 2021

Aquaporin-5 Expression Is Reduced in Lymphocytic Colitis.

Ann Clin Lab Sci 2020 Jul;50(4):447-449

Department of Pathology and Laboratory Medicine

Objective: Aquaporin-5 (AQP5) is a member of a family of water channel proteins involved in the bidirectional transfer of water across cell membranes. Lymphocytic colitis (LC) and collagenous colitis (CC) are clinically similar diseases characterized by chronic watery diarrhea in patients with usually unremarkable colonic mucosa on colonoscopy. The aim of this study was to determine whether AQP5 expression in colonic epithelium is altered in LC and CC. Read More

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Colitis nucleomigrans: The third type of microscopic colitis (part 1).

Pathol Int 2020 Oct 6;70(10):752-760. Epub 2020 Aug 6.

Department of Diagnostic Pathology, Shimada Municipal Hospital, Shizuoka, Japan.

Microscopic colitis (MC), encompassing collagenous colitis and lymphocytic colitis, is featured by chronic diarrhea, normal-looking endoscopic findings and unique microscopic appearance. After reviewing biopsied nonspecific colitis, we propose the third type of MC: colitis nucleomigrans (CN). Histopathological criteria of CN included: (i) chained nuclear migration to the middle part of the surface-lining columnar epithelium; (ii) apoptotic nuclear debris scattered below the nuclei; and (iii) mild/moderate chronic inflammation in the lamina propria. Read More

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October 2020

Les colites microscopiques.

Authors:
P Rivière F Zerbib

Rev Med Interne 2020 Aug 14;41(8):523-528. Epub 2020 Jul 14.

Service d'Hépato-gastroentérologie et Oncologie digestive, Centre Médico-chirurgical Magellan, CHU de Bordeaux, 33600 Pessac, France.

Microscopic colitis is frequently found as a cause of chronic watery diarrhea in women after menopause. The disease can be associated with a medication side effect in half of the patients (non-steroidal anti-inflammatory drugs or proton pump inhibitors for instance). Colonic biopsies are mandatory for the diagnosis of microscopic colitis and should be performed in several locations of the colon. Read More

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Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies.

Hum Pathol 2020 09 13;103:63-71. Epub 2020 Jul 13.

Institute of Pathology, ASST Spedali Civili of Brescia, 25123 Brescia BS, Italy. Electronic address:

The diagnosis of microscopic colitis (MC) relies on specific histopathological findings in colon biopsies. The number of biopsies needed to diagnose MC remains disputed. The aim of the study was to determine the number and site of biopsies necessary for the diagnosis and the effect of perpendicular orientation when embedding the biopsies. Read More

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September 2020

is prevalent in the gastrointestinal tract of patients with microscopic colitis.

Scand J Gastroenterol 2020 Aug 15;55(8):924-930. Epub 2020 Jul 15.

Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.

Objectives: Microscopic colitis (MC) is potentially induced by an inflammatory reaction to a luminal gut factor. The emerging pathogen is associated with prolonged diarrhoea and subsequently increased risk of MC. We aimed to examine the prevalence of in clinical samples from MC patients, analyse the subtypes collagenous colitis (CC) and lymphocytic colitis (LC), and characterise isolates from MC patients by genomic sequencing. Read More

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All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study.

Aliment Pharmacol Ther 2020 07 25;52(2):319-328. Epub 2020 Jun 25.

Department of Gastroenterology, Zealand University Hospital, Køge, Denmark.

Background: The long-term natural history of microscopic colitis remains uncertain.

Aim: To describe the mortality in a large unselected cohort of patients with microscopic colitis.

Methods: All Danish patients above 18 years with an incident diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries and compared to age- and sex-matched controls (variable 1:10 ratio). Read More

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