457 results match your criteria Collagen-Vascular Disease Associated With Interstitial Lung Disease


The contribution of bronchoalveolar lavage in the diagnosis of welder's lung in a patient with pulmonary fibrosis.

Arch Environ Occup Health 2019 Jan 7:1-4. Epub 2019 Jan 7.

b Department of Pathology , Hacettepe University School of Medicine , Ankara , Turkey.

Interstitial pulmonary fibrosis is rare clinical entity related to welding usually associated with long term and heavy exposure to welding fumes. A 56-year-old asymptomatic male patient was referred to our clinic due to abnormal chest X-ray findings that was requested for regular controls. He has been working as a welder both indoor and outdoor settings for the last 25 years. Read More

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http://dx.doi.org/10.1080/19338244.2018.1544113DOI Listing
January 2019

New risk scoring system for predicting acute exacerbation of interstitial pneumonia after chemotherapy for lung cancer associated with interstitial pneumonia.

Lung Cancer 2018 Nov 7;125:253-257. Epub 2018 Oct 7.

Division of Respiratory Medicine, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan.

Background: Fatal acute exacerbation (AE) of interstitial pneumonia (IP) sometimes occurs after chemotherapy for lung cancer. We developed and evaluated a scoring system for assessing AE risk after chemotherapy in patients with lung cancer associated with IP.

Methods: A review of medical records identified 109 patients with primary lung cancer associated with IP who had received chemotherapy at our center during the period from June 2007 through September 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183059
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http://dx.doi.org/10.1016/j.lungcan.2018.10.008DOI Listing
November 2018
11 Reads

Comorbidities of IPF: How do they impact on prognosis.

Pulm Pharmacol Ther 2018 Dec 5;53:6-11. Epub 2018 Sep 5.

Regional Referral Centre for Rare Lung Diseases, A.O.U. Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy. Electronic address:

Idiopathic Pulmonary Fibrosis (IPF) is a severe parenchymal lung disease characterized by an intense deposition of collagen in the interstitial spaces. The introduction of anti-fibrotic drugs increased patients' life expectancy highlighting the role of comorbidities in patients' management and prognosis. IPF is frequently associated with other diseases mainly because of its onset during middle age and sometimes because of the presence of common pathogenic pathways such as in the case of lung cancer. Read More

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http://dx.doi.org/10.1016/j.pupt.2018.09.003DOI Listing
December 2018
7 Reads

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Eur Respir J 2018 Nov 22;52(5). Epub 2018 Nov 22.

Dept of Biochemistry, Universities of Giessen and Marburg Lung Center, Giessen, Germany.

Despite the beneficial effects of pirfenidone in treating idiopathic pulmonary fibrosis (IPF), it remains unclear if lung fibroblasts (FB) are the main therapeutic target.To resolve this question, we employed a comparative transcriptomic approach and analysed lung homogenates (LH) and FB derived from IPF patients treated with or without pirfenidone.In FB, pirfenidone therapy predominantly affected growth and cell division pathways, indicating a major cellular metabolic shift. Read More

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00564
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http://dx.doi.org/10.1183/13993003.00564-2018DOI Listing
November 2018
15 Reads

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis.

Sci Transl Med 2018 Jul;10(451)

Università Vita-Salute San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, via Olgettina 58, 20132 Milano, Italy.

Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma. Microparticles released from activated platelets in the blood of SSc patients (SSc-microparticles) are abundant and express the damage-associated molecular pattern (DAMP) HMGB1. SSc-microparticles interacted with neutrophils in vitro and in immunocompromised mice and promoted neutrophil autophagy, which was characterized by mobilization of their granule content, enhanced proteolytic activity, prolonged survival, and generation of neutrophil extracellular traps (NETs). Read More

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aao3089DOI Listing
July 2018
5 Reads

Multidimensional improvement in connective tissue disease-associated interstitial lung disease: Two courses of pulse dose methylprednisolone followed by low-dose prednisone and tacrolimus.

Respirology 2018 Nov 16;23(11):1041-1048. Epub 2018 Jul 16.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background And Objective: Corticosteroids and immunosuppressive agents are considered mainstays of therapy for connective tissue disease-related interstitial lung disease (CTD-ILD); however, tacrolimus with corticosteroid therapy has not been fully investigated. Our objectives were to examine the multidimensional therapeutic benefit and tolerability of the combined therapy for the initial treatment of patients with CTD-ILD.

Methods: In this retrospective case series, we identified consecutive CTD-ILD patients treated with tacrolimus plus intravenous (i. Read More

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http://dx.doi.org/10.1111/resp.13365DOI Listing
November 2018
4 Reads

A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis.

Respir Res 2018 07 9;19(1):132. Epub 2018 Jul 9.

Laboratory of Respiratory Diseases, Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Herestraat 49, O&N I, box 706, B-3000, Leuven, Belgium.

Background: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the extent of telomere shortening and consequent chromosomal damage within IPF lungs and with regional disease severity remains unknown.

Methods: Explanted IPF lungs (n = 10) were collected from transplant surgeries with six samples per lung analysed to capture the regional heterogeneity ranging from mild to severe disease. Read More

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http://dx.doi.org/10.1186/s12931-018-0838-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038197PMC
July 2018
1 Read

Collagen biomarkers and subclinical interstitial lung disease: The Multi-Ethnic Study of Atherosclerosis.

Respir Med 2018 07 6;140:108-114. Epub 2018 Jun 6.

Department of Medicine, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA; Department of Epidemiology, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA. Electronic address:

Background: Lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover. We examined the association of two collagen biomarkers, carboxy-terminal telopeptide of collagen type I (ICTP) and amino-terminal propeptide of type III procollagen (PIIINP), with subclinical interstitial lung disease (ILD) in adults.

Methods: We performed a cross-sectional analysis of 3244 participants age 45-84 years in the Multi-Ethnic Study of Atherosclerosis. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310068PMC
July 2018
1 Read

Non-specific interstitial pneumonia associated with clinically amyopathic dermatomyositis showing "crazy paving" appearance on thin-section lung CT.

Respirol Case Rep 2018 Jul 3;6(5):e00326. Epub 2018 May 3.

Second Division, Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan.

The "crazy paving" appearance consists of ground-glass opacity superimposed on a network of linear opacities on thin-section computed tomography (CT) images of the lung. This finding has been described in a variety of diseases but is extremely rare in patients with non-specific interstitial pneumonia (NSIP). We describe a 45-year-old woman with biopsy-proven NSIP associated with clinically amyopathic dermatomyositis that showed a "crazy paving" appearance on thin-section CT of the lung. Read More

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http://dx.doi.org/10.1002/rcr2.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933249PMC
July 2018
3 Reads

Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis.

Respir Res 2018 05 10;19(1):90. Epub 2018 May 10.

Department of Pulmonary Medicine, Erasmus MC, s-Gravendijkwal 230, 3015, CE, Rotterdam, The Netherlands.

Background: Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, however fibrocytes in the lungs have not been examined. Read More

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http://dx.doi.org/10.1186/s12931-018-0798-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946532PMC

Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents: evidence of persistent collagen accumulation.

Am J Physiol Lung Cell Mol Physiol 2018 Sep 10;315(3):L390-L403. Epub 2018 May 10.

Department of Respiratory Diseases and Medical Research Center, Pontificia Universidad Católica de Chile , Santiago , Chile.

Recurrent aspiration of gastric contents has been associated with several interstitial lung diseases. Despite this association, the pathogenic role of aspiration in these diseases has been poorly studied and little is known about extracellular matrix (ECM) changes in animal models of repetitive events of aspiration. Our aim was to study the repair phase of lung injury induced by each of several instillations of gastric fluid in Sprague-Dawley rats to evaluate changes in ECM and their reversibility. Read More

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https://www.physiology.org/doi/10.1152/ajplung.00559.2017
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http://dx.doi.org/10.1152/ajplung.00559.2017DOI Listing
September 2018
5 Reads

Leaf Extract Protects against Myocardial Injury via Attenuation of Endoplasmic Reticulum Stress in Streptozotocin-Induced Diabetic ApoE Mice.

Oxid Med Cell Longev 2018 25;2018:2370617. Epub 2018 Feb 25.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Diabetes was induced in high-fat diet-fed ApoE mice via administration of low-dose streptozotocin (STZ) for five days. Mice were then treated with GBE (200 or 400 mg/kg) by gastric gavage daily for 12 weeks. Mice in the untreated diabetic group received saline instead, and nondiabetic C57BL/6J mice served as controls. Read More

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https://www.hindawi.com/journals/omcl/2018/2370617/
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http://dx.doi.org/10.1155/2018/2370617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845491PMC
September 2018
5 Reads

Performance of the St George's Respiratory Questionnaire in patients with connective tissue disease-associated interstitial lung disease.

Respirology 2018 Mar 25. Epub 2018 Mar 25.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background And Objective: The St George's Respiratory Questionnaire (SGRQ) is a self-administered questionnaire used to assess health-related quality of life (HRQoL) in various chronic respiratory diseases. Few studies have assessed the performance of the SGRQ in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). We aimed to examine the SGRQ's performance characteristics and generate data to support its reliability and validity in patients with CTD-ILD. Read More

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http://dx.doi.org/10.1111/resp.13293DOI Listing
March 2018
6 Reads

miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns.

Mol Med Rep 2018 May 19;17(5):7105-7112. Epub 2018 Mar 19.

Laboratory of Molecular and Cellular Pneumonology, Medical School, University of Crete, 71110 Heraklion, Crete, Greece.

Idiopathic pulmonary fibrosis (IPF) and lung cancer (LC) constitute two progressively devastating lung diseases with common risk factors including aging and smoking. There is an increasing interest in the investigation of common pathogenic mechanisms between IPF and LC with therapeutic implications. Several oncomirs, microRNAs associated with malignancy, are also linked with IPF. Read More

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http://dx.doi.org/10.3892/mmr.2018.8778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928671PMC
May 2018
8 Reads

Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease.

Am J Physiol Lung Cell Mol Physiol 2018 Jun 15;314(6):L998-L1009. Epub 2018 Mar 15.

Program in Cell Biology, Department of Pediatrics, National Jewish Health , Denver, Colorado.

Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in ~20% of patients with RA. SKG mice, which are genetically prone to development of autoimmune arthritis, develop a pulmonary interstitial pneumonia that resembles human cellular and fibrotic nonspecific interstitial pneumonia. Nintedanib, a tyrosine kinase inhibitor approved for treatment of idiopathic pulmonary fibrosis, has been shown to reduce the decline in lung function. Read More

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http://dx.doi.org/10.1152/ajplung.00304.2017DOI Listing
June 2018
13 Reads

The lncRNA H19 Mediates Pulmonary Fibrosis by Regulating the miR-196a/COL1A1 Axis.

Inflammation 2018 Jun;41(3):896-903

Department of Respiratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Idiopathic pulmonary fibrosis (IPF) is characterized by lung fibroblasts accumulation and extracellular matrix (ECM) deposition. Recently, long-noncoding RNAs (lncRNAs) have emerged as critical regulators and prognostic markers in several diseases including IPF. In the present study, we found that the expression of H19 was significantly increased in transforming growth factor-β (TGF-β)-induced fibroblast proliferation and bleomycin-(BLM) induced lung fibrosis (p < 0. Read More

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http://dx.doi.org/10.1007/s10753-018-0744-4DOI Listing
June 2018
2 Reads

Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review.

Expert Rev Clin Immunol 2018 01 11;14(1):69-82. Epub 2017 Dec 11.

b Rheumatology Unit, Department of Internal Medicine , ASST-Fatebenefratelli L. Sacco University Hospital , Milan , Italy.

Background: Interstitial lung diseases (ILDs) are among the most serious complications associated with systemic rheumatic diseases, and lead to significant morbidity and mortality; they may also be the first manifestation of connective tissue diseases (CTDs). The aim of this narrative review is to summarise the data concerning the pathogenesis of CTD/ILD and its distinguishing features in different rheumatic diseseas. Areas covered: The pathogenesis, clinical aspects and treatment of ILD associated with rheumatic systemic diseases and CTDs were reviewed by searching the PubMed, Medline, and Cochrane Library databases for papers published between 1995 and February 2017 using combinations of words or terms. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
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http://dx.doi.org/10.1080/1744666X.2018.1411190DOI Listing
January 2018
47 Reads

Radiation toxicity in patients with collagen vascular disease and intrathoracic malignancy treated with modern radiation techniques.

Radiother Oncol 2017 11 5;125(2):301-309. Epub 2017 Nov 5.

Harvard Medical School, Boston, United States; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, United States. Electronic address:

Background And Purpose: There is concern that patients with collagen vascular disease (CVD) are at higher risk of developing radiation toxicity. We analyzed radiation toxicities in patients with intrathoracic malignancy and CVD treated using modern radiotherapy.

Materials And Methods: This single-institution retrospective study included 31 patients with CVD and 825 patients without CVD treated from 1998 to 2014. Read More

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http://dx.doi.org/10.1016/j.radonc.2017.10.002DOI Listing
November 2017
16 Reads

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis.

Stem Cell Rev 2018 04;14(2):223-235

Inserm UMR-S1140, Paris, France.

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by obliteration of alveolar architecture, resulting in declining lung function and ultimately death. Pathogenic mechanisms remain unclear but involve a concomitant accumulation of scar tissue together with myofibroblasts activation. Microparticles (MPs) have been investigated in several human lung diseases as possible pathogenic elements, prognosis markers and therapeutic targets. Read More

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http://dx.doi.org/10.1007/s12015-017-9778-5DOI Listing
April 2018
8 Reads
2.770 Impact Factor

The role of periostin in lung fibrosis and airway remodeling.

Cell Mol Life Sci 2017 12 16;74(23):4305-4314. Epub 2017 Sep 16.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, 4053 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Periostin is a protein that plays a key role in development and repair within the biological matrix of the lung. As a matricellular protein that does not contribute to extracellular matrix structure, periostin interacts with other extracellular matrix proteins to regulate the composition of the matrix in the lung and other organs. In this review, we discuss the studies exploring the role of periostin to date in chronic respiratory diseases, namely asthma and idiopathic pulmonary fibrosis. Read More

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http://dx.doi.org/10.1007/s00018-017-2649-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659879PMC
December 2017
18 Reads

Imipramine blocks acute silicosis in a mouse model.

Part Fibre Toxicol 2017 09 11;14(1):36. Epub 2017 Sep 11.

Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, 59812, USA.

Background: Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics. Read More

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http://dx.doi.org/10.1186/s12989-017-0217-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594487PMC
September 2017
37 Reads

Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial.

BMC Pulm Med 2017 Sep 6;17(1):122. Epub 2017 Sep 6.

Department of Internal Medicine II, University of Giessen-Marburg Lung Center, Justus-Liebig University Giessen, Giessen, Germany.

Background: Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF) and offers a beneficial risk-benefit profile. However, there are several other, progressive fibrotic lung diseases, in which conventional anti-inflammatory therapy is not sufficiently effective and antifibrotic therapies may offer a novel treatment option.

Methods/design: We designed a study protocol for inclusion of patients with progressive fibrotic lung disease despite conventional anti-inflammatory therapy (EudraCT 2014-000861-32). Read More

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http://dx.doi.org/10.1186/s12890-017-0462-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588600PMC
September 2017
24 Reads

The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts.

Int J Nanomedicine 2017 21;12:6089-6105. Epub 2017 Aug 21.

Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Recent progress in nanomedicine has shown a strong possibility of targeted therapy for obstinate chronic lung diseases including idiopathic pulmonary fibrosis (IPF). IPF is a fatal lung disease characterized by persistent fibrotic fibroblasts in response to type I collagen-rich extracellular matrix. As a pathological microenvironment is important in understanding the biological behavior of nanoparticles, in vitro cellular uptake of glycol chitosan nanoparticles (CNPs) in human lung fibroblasts was comparatively studied in the presence or absence of type I collagen matrix. Read More

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http://dx.doi.org/10.2147/IJN.S138129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573064PMC
March 2018
6 Reads

IPF lung fibroblasts have a senescent phenotype.

Am J Physiol Lung Cell Mol Physiol 2017 Dec 31;313(6):L1164-L1173. Epub 2017 Aug 31.

The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Pittsburgh, Pennsylvania;

The mechanisms of aging that are involved in the development of idiopathic pulmonary fibrosis (IPF) are still unclear. Although it has been hypothesized that the proliferation and activation of human lung fibroblasts (hLFs) are essential in IPF, no studies have assessed how this process works in an aging lung. Our goal was to elucidate if there were age-related changes on primary hLFs isolated from IPF lungs compared with age-matched controls. Read More

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http://dx.doi.org/10.1152/ajplung.00220.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148001PMC
December 2017
15 Reads

Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.

BMC Med Genet 2017 08 18;18(1):88. Epub 2017 Aug 18.

Department of Molecular and Internal Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Chronic fibrosing idiopathic interstitial pneumonia (IIP) is characterized by alveolar epithelial damage, activation of fibroblast proliferation, and loss of normal pulmonary architecture and function. This study aims to investigate the genetic backgrounds of IIP through gene expression profiling and pathway analysis, and to identify potential biomarkers that can aid in diagnosis and serve as novel therapeutic targets.

Methods: RNA extracted from lung specimens of 12 patients with chronic fibrosing IIP was profiled using Illumina Human WG-6 v3 BeadChips, and Ingenuity Pathway Analysis was performed to identify altered functional and canonical signaling pathways. Read More

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http://dx.doi.org/10.1186/s12881-017-0449-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562997PMC
August 2017
38 Reads

Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features.

BMC Pulm Med 2017 Aug 14;17(1):111. Epub 2017 Aug 14.

Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.

Background: To identify the prognostic factors for survival in patients with interstitial pneumonia with autoimmune features (IPAF) who meet the serological domain of the IPAF criteria.

Methods: We retrospectively analysed 99 IPAF patients who met the serological domain and were hospitalised at the Respiratory Medicine Unit of Kurashiki Central Hospital from 1999 to 2015. The high-resolution computed tomography findings were usual interstitial pneumonia (UIP; n = 1), non-specific interstitial pneumonia (NSIP; n = 63), NSIP with organizing pneumonia (OP) overlap (n = 15), and OP (n = 20). Read More

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http://dx.doi.org/10.1186/s12890-017-0453-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554971PMC
August 2017
24 Reads

Fibrocyte measurement in peripheral blood correlates with number of cultured mature fibrocytes in vitro and is a potential biomarker for interstitial lung disease in Rheumatoid Arthritis.

Respir Res 2017 07 18;18(1):141. Epub 2017 Jul 18.

Department Clinical Immunology, Odense University Hospital, Odense, Denmark.

Background: Interstitial lung disease (ILD) can be a severe extra-articular disease manifestation in Rheumatoid Arthritis (RA). A potential role of fibrocytes in RA associated ILD (RA-ILD) has not previously been described. We present a modified faster method for measuring circulating fibrocytes, without intracellular staining. Read More

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http://dx.doi.org/10.1186/s12931-017-0623-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516315PMC
July 2017
3 Reads

Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view.

Korean J Intern Med 2017 Jul 30;32(4):600-610. Epub 2017 Jun 30.

Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soon Chun Hyang University Seoul Hospital, Seoul, Korea.

Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be a significant cause of mortality in patients with CVD-associated ILD (CTD-ILD). There is a lack of randomized, clinical trials assessing pharmacological agents for CTD-ILD, except in cases of ILD-associated systemic sclerosis (SSc). Read More

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http://dx.doi.org/10.3904/kjim.2016.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511941PMC
July 2017
39 Reads

Elevated serum D-dimer level is associated with an increased risk of acute exacerbation in interstitial lung disease.

Respir Med 2017 07 19;128:78-84. Epub 2017 May 19.

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Background: Early recognition of patients with interstitial lung disease (ILD) who have an increased risk of developing acute exacerbation (AE) or preclinical AE may be clinically useful, since AE is associated with poor outcome and preventive measures would be of interest to ILD researchers. This study evaluated the relationship between elevated serum D-dimer level (≥0.4 mcg/mL) and subsequent AE or preclinical AE in patients with ILD. Read More

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http://dx.doi.org/10.1016/j.rmed.2017.05.009DOI Listing
July 2017
3 Reads
3.090 Impact Factor

Interstitial Lung Disease in Women of Child-Bearing Age.

Semin Respir Crit Care Med 2017 04 22;38(2):185-190. Epub 2017 May 22.

Division of Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Interstitial lung disease (ILD) is an inflammatory and fibrotic infiltrative process of the lung that is often associated with collagen vascular disease in women. Untreated, it results in collagen deposition in the lung interstitium that can lead to a slow suffocating death. Pregnancy planning is often not discussed with women who have ILD due to concerns about potentially aggravating the disease process, or due to lack of knowledge about the safety of medications used to treat ILD. Read More

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http://dx.doi.org/10.1055/s-0037-1602243DOI Listing
April 2017
13 Reads

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.

Nature 2017 05 3;545(7653):243-247. Epub 2017 May 3.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria 3168, Australia.

Susceptibility and protection against human autoimmune diseases, including type I diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human leukocyte antigen (HLA) alleles. However, the mechanisms underpinning such HLA-mediated effects on self-tolerance remain unclear. Here we investigate the molecular mechanism of Goodpasture disease, an HLA-linked autoimmune renal disorder characterized by an immunodominant CD4 T-cell self-epitope derived from the α3 chain of type IV collagen (α3). Read More

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http://www.nature.com/doifinder/10.1038/nature22329
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http://dx.doi.org/10.1038/nature22329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903850PMC
May 2017
42 Reads

Direct hemoperfusion with polymyxin B-immobilized fibre treatment for acute exacerbation of interstitial pneumonia.

Respirology 2017 10 25;22(7):1357-1362. Epub 2017 Apr 25.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background And Objective: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is recognized as an important cause of mortality. AE has also been reported in patients with other interstitial lung diseases such as idiopathic non-specific interstitial pneumonia (NSIP) and interstitial pneumonia associated with collagen vascular disease (CVD). Current therapies such as high-dose corticosteroid with immunosuppressive agents have provided little benefit for AE. Read More

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http://doi.wiley.com/10.1111/resp.13054
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http://dx.doi.org/10.1111/resp.13054DOI Listing
October 2017
14 Reads

Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models.

Sci Transl Med 2017 04;9(384)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity, environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis (IPF)]. Overexpression of collagen is a hallmark of organ fibrosis. We describe a peptide-based positron emission tomography (PET) probe (Ga-CBP8) that targets collagen type I. Read More

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aaf4696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568793PMC
April 2017
13 Reads

Cytokine modulation in patients with idiopathic pulmonary fibrosis undergoing treatment with steroids, immunosuppressants, and IFN-γ 1b.

J Biol Regul Homeost Agents 2017 Jan-Mar;31(1):59-69

Department of Medical, Oral and Biotechnological Sciences, University of Chieti, Italy.

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown etiology and pathogenic mechanisms. From an etiopathogenic point of view, alveolar macrophages play a key role in accumulation of fibroblasts and deposition of collagen and extracellular matrix by releasing specific cytokines and inflammatory mediators. IPF seems to be also associated with circulating fibrocytes, which might be involved with an abnormal pulmonary vascular repair and remodeling. Read More

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June 2017
3 Reads

Effects of nintedanib on the microvascular architecture in a lung fibrosis model.

Angiogenesis 2017 Aug 10;20(3):359-372. Epub 2017 Mar 10.

Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 13, 55128, Mainz, Germany.

Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the impact of nintedanib on microvascular architecture in a pulmonary fibrosis model. Lung fibrosis was induced in C57Bl/6 mice by intratracheal bleomycin (0. Read More

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http://dx.doi.org/10.1007/s10456-017-9543-zDOI Listing
August 2017
37 Reads

Effect of collagen vascular disease-associated interstitial lung disease on the outcomes of lung cancer surgery.

Surg Today 2017 Sep 28;47(9):1072-1079. Epub 2017 Feb 28.

Department of Surgery I, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Purpose: This study compared the effect of collagen vascular disease-associated interstitial lung disease (CVD-ILD) with that of idiopathic interstitial pneumonias (IIPs) on the outcomes of lung cancer surgery.

Methods: This study retrospectively reviewed the medical records of patients who underwent surgery for non-small cell lung cancer (NSCLC) and compared the data of 16 patients with CVD-ILD with those of 70 patients with IIPs. The patterns of interstitial lung disease (ILD) on chest computed tomography were classified into usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) patterns. Read More

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http://dx.doi.org/10.1007/s00595-017-1476-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532416PMC
September 2017
12 Reads

Global DNA hypomethylation has no impact on lung function or serum inflammatory and fibrosis cytokines in asbestos-exposed population.

Int Arch Occup Environ Health 2017 Apr 19;90(3):265-274. Epub 2017 Jan 19.

Department of Occupational and Environmental Health Science, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100191, People's Republic of China.

Purpose: To examine the effect of asbestos exposure on global DNA methylation and determine whether lung function and inflammatory and fibrosis biomarkers are correlated with the methylation state.

Methods: A total of 26 healthy subjects without asbestos exposure (Group 1), 47 healthy subjects with exposure (Group 2), and 52 subjects with benign asbestos-related disorders (ARDs) (Group 3) participated in this cross-sectional study. Blood global 5-methylcytosine (5mC) and serum TNF-α, collagen IV, CCL5 and CC16 concentrations were analyzed using enzyme-linked immunosorbent assay-like assays. Read More

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http://dx.doi.org/10.1007/s00420-017-1195-1DOI Listing
April 2017
7 Reads

Tissue remodelling in pulmonary fibrosis.

Cell Tissue Res 2017 03 16;367(3):607-626. Epub 2016 Dec 16.

Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into diseases with known and unknown aetiology. Among those with unknown aetiology, idiopathic pulmonary fibrosis (IPF) is a common diagnosis. Read More

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http://dx.doi.org/10.1007/s00441-016-2543-2DOI Listing
March 2017
24 Reads

Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin.

Respir Res 2016 11 29;17(1):162. Epub 2016 Nov 29.

INSERM, LNC UMR866, LipSTIC LabEx team, Université Bourgogne Franche-Comté, 21000, Dijon, France.

Background: Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenotype under fibrotic conditions induced by TGF-β1 or bleomycin. The importance and role of inflammation in fibrogenesis are still controversial. Read More

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http://dx.doi.org/10.1186/s12931-016-0475-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127006PMC
November 2016
5 Reads

Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica.

Respir Res 2016 11 28;17(1):160. Epub 2016 Nov 28.

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Louisville, Louisville, KY, 40202, USA.

Background: Occupational and environmental exposure to crystalline silica may lead to the development of silicosis, which is characterized by inflammation and progressive fibrosis. A substantial number of patients diagnosed with silicosis develop pulmonary hypertension. Pulmonary hypertension associated with silicosis and with related restrictive lung diseases significantly reduces survival in affected subjects. Read More

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http://dx.doi.org/10.1186/s12931-016-0478-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126840PMC
November 2016
49 Reads

Pulmonary involvement in systemic sclerosis.

Autoimmun Rev 2016 Nov 4;15(11):1094-1108. Epub 2016 Aug 4.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia. Electronic address:

Systemic sclerosis (SSc) is a multi-systemic autoimmune disease that mainly affects the skin, lungs, gastrointestinal tract, heart and kidneys. Pulmonary disease in patients with SSc is strongly associated with mortality. The mechanisms involved into its pathophysiology include the activation of autoimmune cells and hyperplasia of fibroblasts with an increased capacity to produce collagen and diminished collagen breakdown. Read More

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http://dx.doi.org/10.1016/j.autrev.2016.07.025DOI Listing
November 2016
16 Reads
7 Citations
7.933 Impact Factor

Influence of Smoking in Interstitial Pneumonia Presenting with a Non-Specific Interstitial Pneumonia Pattern.

Intern Med 2016;55(20):2939-2944. Epub 2016 Oct 15.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.

Objective The influence of smoking on the pathogenesis and clinical course of interstitial pneumonia has recently attracted attention. To clarify the influence of smoking on the clinical patient characteristics and therapeutic effects in patients with interstitial pneumonia presenting with a non-specific interstitial pneumonia (NSIP) pattern, we compared the clinical patient characteristics and therapeutic effects in smokers and nonsmokers in this study. Methods We divided 31 NSIP (16 idiopathic nonspecific interstitial pneumonia and 15 collagen vascular disease-associated nonspecific interstitial pneumonia) patients into smoker and non-smoker groups for each case. Read More

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http://dx.doi.org/10.2169/internalmedicine.55.6890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109559PMC
February 2017
21 Reads

Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.

Biomed Environ Sci 2016 Aug;29(8):584-588

School of Public Health, North China University of Science and Technology, Hebei province coal mine health and safety laboratory, Tangshan 063000, Hebei, China.

Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates. Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities. Read More

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http://dx.doi.org/10.3967/bes2016.077DOI Listing
August 2016
5 Reads

[Pulmonary manifestations in collagen vascular diseases].

Radiologe 2016 Oct;56(10):910-916

Abteilung für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland.

Clinical/methodical Issue: Pulmonary complications are frequent in patients with collagen vascular diseases (CVD). Frequent causes are a direct manifestation of the underlying disease, side effects of specific medications and lung infections.

Standard Radiological Methods: The standard radiological procedure for the work-up of pulmonary pathologies in patients with CVD is multidetector computed tomography (MDCT) with thin-slice high-resolution reconstruction. Read More

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http://dx.doi.org/10.1007/s00117-016-0157-zDOI Listing
October 2016
16 Reads

D1398G Variant of MET Is Associated with Impaired Signaling of Hepatocyte Growth Factor in Alveolar Epithelial Cells and Lung Fibroblasts.

PLoS One 2016 1;11(9):e0162357. Epub 2016 Sep 1.

Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America.

Pulmonary fibrosis represents the terminal stage of a diverse group of lung diseases including scleroderma associated interstitial lung disease. The molecular mechanisms underlying the pathogenesis of lung fibrosis are not well understood and there is a great need for more effective treatment for this lethal disease. We recently discovered a small fragment of hepatocyte growth factor (HGF) receptor MET as a peptide designated "M10," with strong antifibrotic properties. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162357PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008815PMC
August 2017
9 Reads

Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study.

Int J Mol Sci 2016 Aug 22;17(8). Epub 2016 Aug 22.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

LncRNA-ATB (lncRNA was activated by transforming growth factor-β) has been reported to be involved in specific physiological and pathological processes in human diseases, and could serve as biomarkers for cancers. However, the role of lncRNA-ATB in coal workers' pneumoconiosis (CWP) is still unknown. This study aimed to investigate the association between lncRNA-ATB and CWP. Read More

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http://dx.doi.org/10.3390/ijms17081367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000762PMC
August 2016
22 Reads

Original Research: ACE2 activator associated with physical exercise potentiates the reduction of pulmonary fibrosis.

Exp Biol Med (Maywood) 2017 Jan 21;242(1):8-21. Epub 2016 Aug 21.

Departamento de Patologia Geral, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, CEP 31 270-901, Brasil

The interstitial lung diseases are poorly understood and there are currently no studies evaluating the association of physical exercise with an ACE2 activator (DIZE) as a possible treatment for this group of diseases. We evaluate the effects of pharmacological treatment with an angiotensin-converting enzyme 2 activator drug, associated with exercise, on the pulmonary lesions induced by bleomycin. From the 96 male Balb/c mice used in the experiment, only 49 received 8 U/kg of bleomycin (BLM, intratracheally). Read More

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http://journals.sagepub.com/doi/10.1177/1535370216665174
Publisher Site
http://dx.doi.org/10.1177/1535370216665174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206984PMC
January 2017
9 Reads

Platelet aggregability in patients with interstitial pneumonias.

Sarcoidosis Vasc Diffuse Lung Dis 2016 Aug 1;33(2):143-50. Epub 2016 Aug 1.

Assistant professor Department of respiratory medicine Kyoto university hospital.

Background: Recent epidemiological studies have shown that patients with interstitial pneumonia have an increased risk of cardiovascular events. Although the presence of a coagulation/fibrinolysis abnormality in idiopathic pulmonary fibrosis (IPF) has been reported, platelet aggregability has not been evaluated in interstitial pneumonias. This study aimed to investigate platelet aggregability in patients with interstitial pneumonias. Read More

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August 2016
7 Reads

Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.

J Hum Genet 2016 Dec 4;61(12):985-993. Epub 2016 Aug 4.

Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that is refractory to treatment and carries a high mortality rate. IPF is frequently associated with lung cancer. Identification of molecular targets involved in both diseases may elucidate novel molecular mechanisms contributing to their pathology. Read More

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http://dx.doi.org/10.1038/jhg.2016.99DOI Listing
December 2016
18 Reads

Successful Treatment of Aspergillus Empyema Using Open Window Thoracostomy Salvage Treatment and the Local Administration of an Antifungal Agent.

Intern Med 2016 1;55(15):2093-9. Epub 2016 Aug 1.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.

A 76-year-old woman received long-term immunosuppressive treatment for collagen vascular disease-associated interstitial pneumonia. The patient developed a cavitary mass lesion in the right lower lung field, and both nontuberculous mycobacteria and Aspergillus spp. were isolated after bronchial washing. Read More

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http://dx.doi.org/10.2169/internalmedicine.55.6250DOI Listing
March 2017
33 Reads