2,441 results match your criteria Colitis Ischemic

Colonoscopy induced ischemic colitis: An endoscopic and histological assay.

Clin Res Hepatol Gastroenterol 2022 Jun 24:101975. Epub 2022 Jun 24.

Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India. Electronic address:

Colonoscopy is a safe and effective diagnostic modality for various ileo-colonic diseases. Though the procedure itself is a rare cause of ischaemic colitis. Fewer than 30 cases of ischaemic colitis caused by colonoscopy procedure have been reported in the literature to date. Read More

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CD8 Lymphocyte Infiltration Is a Specific Feature of Colitis Induced by Immune Checkpoint Inhibitors.

Dig Dis Sci 2022 Jun 24. Epub 2022 Jun 24.

Department of Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Immune checkpoint inhibitors (ICPIs) have revolutionized cancer therapy, although immune-related adverse events (irAEs) remain a serious issue. The clinical characteristics of colitis induced by ICPIs are very similar to inflammatory bowel disease. Recently, cluster of differentiation 8 positive (CD8) lymphocyte infiltration into organs has been associated with the onset of irAEs. Read More

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PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary.

It is increasingly known that Parkinson's (PD) and Alzheimer's (AD) diseases occur more frequently in patients with inflammatory gastrointestinal diseases including inflammatory bowel (IBD) or celiac disease, indicating a pathological link between them. Although epidemiological observations suggest the existence of the gut-brain axis (GBA) involving systemic inflammatory and neural pathways, little is known about the exact molecular mechanisms. Parkinson's disease 7 (PARK7/DJ-1) is a multifunctional protein whose protective role has been widely demonstrated in neurodegenerative diseases, including PD, AD, or ischemic stroke. Read More

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Clinical features and risk factors for ischemic colitis in young and middle-aged patients.

W Cai J Zhu D Hu

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):283-290

Department of Gastroenterology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China.

Background And Study Aims: Ischemic colitis (IC) is thought to occur more frequently in the elderly, but the incidence in young and middle-aged adults is increasing. This study determined the clinical characteristics of and risk factors for young and middle-aged IC patients.

Patients And Methods: The medical records of 190 IC patients from 2010-2020 were reviewed. Read More

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Mapping of etiologies of computed tomography-proven acute colitis: a prospective cohort study.

Sci Rep 2022 Jun 13;12(1):9730. Epub 2022 Jun 13.

Division of Digestive Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland.

Our objective was to describe the etiologies of acute colitis and to identify patients who require diagnostic endoscopy. Patients with symptoms of gastrointestinal infection and colonic inflammation on CT were prospectively included. Those immunosuppressed, with history of colorectal cancer or inflammatory bowel disease (IBD), were excluded. Read More

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An 80-Year-Old Man with Hematochezia and Hyperkalemia.

Gastroenterology 2022 Jun 3. Epub 2022 Jun 3.

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.

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Ischemic colitis after receiving the second dose of a COVID-19 inactivated vaccine: A case report.

World J Clin Cases 2022 Apr;10(12):3866-3871

Department of Gastroenterology, Aerospace Center Hospital, Beijing 100049, China.

Background: The outbreak of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has been the most important clinical challenge worldwide since January 2020. COVID-19 inactivated vaccines play a crucial role in reducing the rates of morbidity and mortality.

Case Summary: We presented a 48-year-old woman from Haidian District, Beijing, China who developed ischemic colitis after receiving the second dose of COVID-19 inactivated vaccine. Read More

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Congestive Heart Failure Is Associated With Worse Outcomes in Patients With Ischemic Colitis: A Nationwide Study.

Cureus 2022 Apr 20;14(4):e24308. Epub 2022 Apr 20.

Gastroenterology, Kent Hospital/Brown Unviersity, Warwick, USA.

Introduction: Ischemic colitis (IC) results from compromised blood flow to the colon. Risk factors include atrial fibrillation (A.Fib), peripheral artery disease (PAD), coronary artery disease (CAD), and congestive heart failure (CHF). Read More

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Detection of Ischemic Colitis on Routine Lower Endoscopy and Its Implications After Repair of Ruptured Abdominal Aortic Aneurysm.

Am Surg 2022 May 16:31348221101520. Epub 2022 May 16.

Section of Colon and Rectal Surgery, 138207Albany Medical Center, Albany, NY, USA.

Background: Ischemic colitis (IC) is a known significant complication after repair of a ruptured abdominal aortic aneurysm (rAAA). Lower endoscopy (colonoscopy or flexible sigmoidoscopy) is a helpful adjunct to aid decision making for surgical exploration. We believe routine use of lower endoscopy after rAAA repair provides better patient care through expeditious diagnosis and surgical care. Read More

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Hydroxychloroquine safety in Covid-19 vs non-Covid-19 patients: analysis of differences and potential interactions.

Expert Opin Drug Saf 2022 May 19:1-9. Epub 2022 May 19.

Centro de Estudios sobre la Seguridad de los Medicamentos (CESME). Departamento de Biología Celular, Histología, Farmacología y Genética. Facultad de Medicina. Universidad de Valladolid, Valladolid, Spain.

Background: The use of hydroxychloroquine (HCQ) in the first COVID-19 epidemic wave raised safety concerns.

Research Design And Methods: Adverse reactions (ADR) suspected to be induced by HCQ and submitted to the Spanish Pharmacovigilance Database were studied. A disproportionality analysis was performed to determine adverse effects reported in non-Covid and Covid patients. Read More

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Therapeutic Potential of Exosomes Derived from Adipose Tissue-Sourced Mesenchymal Stem Cells in the Treatment of Neural and Retinal Diseases.

Int J Mol Sci 2022 Apr 19;23(9). Epub 2022 Apr 19.

Department of Cognitive Psychology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.

Therapeutic agents that are able to prevent or attenuate inflammation and ischemia-induced injury of neural and retinal cells could be used for the treatment of neural and retinal diseases. Exosomes derived from adipose tissue-sourced mesenchymal stem cells (AT-MSC-Exos) are extracellular vesicles that contain neurotrophins, immunoregulatory and angio-modulatory factors secreted by their parental cells. AT-MSC-Exos are enriched with bioactive molecules (microRNAs (miRNAs), enzymes, cytokines, chemokines, immunoregulatory, trophic, and growth factors), that alleviate inflammation and promote the survival of injured cells in neural and retinal tissues. Read More

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Ischemic colitis after COVID-19 mRNA vaccine.

Endoscopy 2022 May 13. Epub 2022 May 13.

Department of Gastroenterology, Ameos Teaching University Hospital (Otto-von-Guericke University - Magdeburg), Halberstadt, Germany.

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Lactulose-Induced Ischemic Colitis: A Rare Presentation and an Overview of Possible Etiologies of the Disease.

Cureus 2022 Apr 3;14(4):e23774. Epub 2022 Apr 3.

Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.

Ischemic colitis is one of the most common ischemic pathologies of the gastrointestinal system and can be divided into non-gangrenous and gangrenous forms. The pathophysiology involves restricted blood supply to the colonic mucosa. Several risk factors have been implicated in the development of ischemic colitis. Read More

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Clinical characteristics and long-term outcomes of hospitalised patients with ischemic colitis with different degrees of haematochezia: a retrospective study.

Eur J Gastroenterol Hepatol 2022 May 2. Epub 2022 May 2.

Department of Gastroenterology and Hepatology, Jinling Hospital, Nanjing Medical University.

Background: Based on the literature, haematochezia is associated with a benign clinical course of ischaemic colitis. However, most cases in the literature presented mild haematochezia associated with ischaemic colitis. Therefore, we aimed to investigate the impact of different degrees of haematochezia on the clinical outcomes of ischaemic colitis. Read More

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Emphasis on Early Identification of Risk Factors to Curtail High Mortality Involved With Ischemic Colitis (IC) After Abdominal Aortic Aneurysm (AAA) Repair.

Cureus 2022 Mar 25;14(3):e23492. Epub 2022 Mar 25.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Ischemic colitis (IC) is one of the most feared complications after abdominal aortic aneurysm (AAA) repair. Though the complication is seen in only a handful of total repairs, the mortality rates after IC is very high. Due to infrequent presentation, attending doctors may overlook this possibility leading to a delay in diagnosis. Read More

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Laninamivir-induced ischemic enterocolitis: A case report.

World J Clin Cases 2022 Mar;10(9):2864-2870

Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tanba 669-3495, Japan.

Background: Neuraminidase inhibitor-associated acute hemorrhagic colitis is rare. We report a case of ischemic enterocolitis that was likely caused by laninamivir.

Case Summary: A 54-year-old female patient with influenza type A was administered 40 mg of laninamivir inhalation once. Read More

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Takayasu Arteritis Complicated by Ischemic Colitis: A Case Report.

Ann Vasc Dis 2022 Mar;15(1):68-71

First Department of Surgery, University of Toyama, Toyama, Toyama, Japan.

Takayasu arteritis is an inflammatory disease of the aorta and its major branches, which results in stenosis and aneurysm formation. Lesions of the abdominal aorta and renal arteries are common. Nevertheless, lesions of the celiac and superior mesenteric arteries are less common. Read More

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Methamphetamine-Induced Bowel Ischemia in a 50-Year-Old Male.

Case Rep Crit Care 2022 5;2022:9690034. Epub 2022 Apr 5.

St. Joseph's Medical Center/Dignity Health, 1800 N California St., Stockton, CA 95204, USA.

Methamphetamine intoxication is a known risk factor for nonocclusive mesenteric ischemia (NOMI). We describe a case of a 50-year-old male with a history of polysubstance abuse who presented to the Emergency Department with severe abdominal pain and coffee-ground emesis. Computed tomographic (CT) imaging demonstrated portal venous gas and diffuse colonic wall thickening concerning for ischemic colitis. Read More

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RORγt-Expressing Pathogenic CD4 T Cells Cause Brain Inflammation during Chronic Colitis.

J Immunol 2022 04 4;208(8):2054-2066. Epub 2022 Apr 4.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL;

Neurobehavioral disorders and brain abnormalities have been extensively reported in both Crohn's disease and ulcerative colitis patients. However, the mechanism causing neuropathological disorders in inflammatory bowel disease patients remains unknown. Studies have linked the Th17 subset of CD4 T cells to brain diseases associated with neuroinflammation and cognitive impairment, including multiple sclerosis, ischemic brain injury, and Alzheimer's disease. Read More

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Development and validation of a composite score to predict severe forms of ischemic colitis.

Eur Radiol 2022 Mar 30. Epub 2022 Mar 30.

Department of Imaging, Hospital Lapeyronie, CHU Montpellier, Montpellier, France.

Objective: To develop a simple scoring system in order to predict the risk of severe (death and/or surgery) ischemic colitis METHODS: In this retrospective study, 205 patients diagnosed with ischemic colitis in a tertiary hospital were consecutively included over a 6-year period. The study sample was sequentially divided into a training cohort (n = 103) and a validation cohort (n = 102). In the training cohort, multivariable analysis was used to identify clinical, biological, and CT variables associated with poor outcome and to build a risk scoring system. Read More

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Abdominopelvic actinomycosis: An unexpected diagnosis in an elderly female with a destructive-appearing soft tissue mass.

IDCases 2022 19;28:e01479. Epub 2022 Mar 19.

Department of Internal Medicine, AMITA Health St. Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.

We present the case of an elderly female who underwent a workup for acute blood loss anemia that incidentally led to the discovery of abdominopelvic actinomycosis. While esophagogastroduodenoscopy and colonoscopy were unremarkable, CT abdomen/pelvis displayed a soft tissue mass in the left sacral ala and presacral area that appeared suspicious for malignancy. MRI pelvis revealed a presacral abscess, and an IR-guided biopsy cemented the diagnosis. Read More

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COVID-19-Associated Ischemic Colitis: A Rare Manifestation of COVID-19 Infection-Case Report and Review.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211065625

Blanchard Valley Health System, Findlay, OH, USA.

Following the first report of COVID-19 infection in December 2019 as a respiratory illness, it has proven to be a multisystem disease. There are few reported cases of ischemic colitis with COVID-19 infection in the medical literature to date and we have limited understanding of its pathophysiology. We report 2 cases of ischemic colitis as the only manifestation of COVID-19. Read More

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Phlebosclerotic colitis with long-term herbal medicine use.

Radiol Case Rep 2022 May 22;17(5):1696-1701. Epub 2022 Mar 22.

Department of Radiology, Hanoi Medical University, Hanoi, Vietnam.

Phlebosclerotic colitis (PC), also known as idiopathic mesenteric phlebosclerosis, is a rare disease resulting in ischemic colon due to venous sclerosis and calcifications that can be identified by characteristic imaging features on computed tomography and colonoscopy. Clinical examination reveals nonspecific symptoms with slow progression in the majority of cases. Patients with PC often require late-stage hospitalization and colectomy. Read More

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Acute right-sided ischemic colitis in a COVID-19 patient: a case report and review of the literature.

J Med Case Rep 2022 Mar 25;16(1):135. Epub 2022 Mar 25.

Department of Digestive Surgery, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.

Introduction: In addition to attacking the respiratory system, the coronavirus disease may attack the gastrointestinal tract in various ways, one of which is by creating a coagulopathy that may lead to acute ischemia of the bowel, increasing morbidity and mortality rates in these patients.

Presentation Of Case: We present a case of a white 72-year-old European male, who was admitted to the intensive care unit after developing COVID-19-induced acute respiratory distress syndrome. On the third week, despite a favorable evolution of his respiratory symptoms, the patient became clinically septic; laboratory findings showed an augmentation of his D-dimer, fibrinogen, C-reactive protein, and procalcitonin levels. Read More

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Minimally Invasive Surgical Approach to Toxic Colitis.

Am Surg 2022 Jul 25;88(7):1411-1419. Epub 2022 Mar 25.

Department of Surgery, 2012NYC Health and Hospitals-Elmhurst, Queens, NY, USA.

Background: We aimed to compare outcomes of surgical treatments of toxic colitis (infectious/inflammatory/ischemic) by the extent of colectomy (partial vs total colectomy) and different surgical approaches (minimally invasive surgery (MIS) vs open).

Methods: Multivariate analysis using logistic regression was used to investigate outcomes of patients with toxic colitis who underwent emergent colectomy during 2012-2019 by surgical approach and the extent of resection using NSQIP database.

Results: Overall, 2,104 adult patients underwent emergent colectomy for toxic colitis within NSQIP database during 2012-2019. Read More

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Clinic, Endoscopic and Histological Features in Patients Treated with ICI Developing GI Toxicity: Some News and Reappraisal from a Mono-Institutional Experience.

Diagnostics (Basel) 2022 Mar 11;12(3). Epub 2022 Mar 11.

Division of Gastroenterology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, 71013 Foggia, Italy.

Immune checkpoint inhibitors (ICIs) have widened the therapeutic scenario of different solid tumors over the last ten years. Gastrointestinal (GI) adverse events (AEs), such as diarrhea and colitis, occur in up to 50% of patients treated with ICIs. We conducted a single-center retrospective analysis in patients with solid tumors treated with ICIs in a 6-year period, from 2015 to 2021, developing GI AEs, for which an endoscopic analysis was performed, with available histological specimens or surgery. Read More

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Hypereosinophilic syndrome presenting as coagulopathy.

Allergy Asthma Clin Immunol 2022 Mar 22;18(1):25. Epub 2022 Mar 22.

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.

Background: Hypereosinophilic syndrome (HES) is an extremely uncommon group of disorders. It rarely presents with coagulopathy without cardiac involvement.

Case Presentation: A 33-year-old previously healthy male with no history of atopic disease presented with abdominal pain, hematochezia, peripheral eosinophilia as high as 10,000 eos/µL, right and left portal vein, mesenteric, and splenic vein thrombi with ischemic colitis resulting in hemicolectomy and small bowel resection. Read More

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An Israeli national survey on ischemic colitis induced by pre-colonoscopy bowel preparation (R1).

Acta Gastroenterol Belg 2022 Jan-Mar;85(1):94-96

Departments of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Background And Study Aims: Ischemic colitis (IC) may occur as a complication of colonoscopy. The aim of this study was to characterize patients with IC that occurred after exposure to bowel preparation laxatives, prior to an elective colonoscopy.

Patients And Methods: A survey among Israeli gastroenterologists. Read More

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Factors influencing hospital stay duration for patients with mild ischemic colitis: a retrospective study.

Eur J Med Res 2022 Mar 5;27(1):36. Epub 2022 Mar 5.

Department of Gastroenterology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.

Background: Ischemic colitis is the most prevalent ischemic injury of the gastrointestinal tract. The majority of patients with mild ischemic colitis usually achieve complete clinical recovery shortly. However, the predictors of longer hospital stay duration are unclear. Read More

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Helicobacter pylori infection manifesting as Hypereosinophilic syndrome and immune thrombocytopenia complicated by portal vein thrombosis and ischemic colitis.

IDCases 2022 12;27:e01451. Epub 2022 Feb 12.

Hamad Medical Corporation, Doha, Qatar.

Hypereosinophilic syndromes (HES) are a group of uncommon disorders characterized by persistent eosinophils overproduction which can lead to tissue damage and organs dysfunction secondary to eosinophils tissue infiltration and inflammatory mediators' release. Causes of secondary HES include parasitic infection, some solid tumors, underlying connective tissue disease, allergic conditions and T cell lymphoma. has been reported only once as a cause of secondary HES in the literature. Read More

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February 2022