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J Am Acad Dermatol 2021 May 1. Epub 2021 May 1.

Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Primary cutaneous T-cell lymphomas (CTCLs) other than Mycosis Fungoides (MF) and Sézary syndrome (SS) encompass a heterogenous group of non-Hodgkin lymphomas with variable clinical course, prognoses, and management. With morphologic and histologic overlap among the CTCL subtypes and other T-cell lymphomas with cutaneous manifestations, thorough evaluation with clinicopathologic correlation and exclusion of systemic involvement are essential prior to initiating therapy. Staging and treatment recommendations vary depending on the subtype, clinical behavior, and treatment response. Read More

J Am Acad Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Primary cutaneous T-cell lymphomas (CTCLs) are defined as lymphomas with a T-cell phenotype that present in the skin without evidence of systemic or extracutaneous disease at initial presentation. CTCLs other than Mycosis Fungoides (MF) and Sézary syndrome (SS) account for approximately one-third of CTCLs and encompass a heterogenous group of non-Hodgkin lymphomas ranging from indolent lymphoproliferative disorders to aggressive malignancies with a poor prognosis. The spectrum of CTCLs continues to broaden as new provisional entities are classified. Read More

Ned Tijdschr Geneeskd 2021 04 28;165. Epub 2021 Apr 28.

Saxenburgh Medisch Centrum, afd. Interne Geneeskunde, Hardenberg.

Background: Diseases of the pancreas may present with extrapancreatic symptoms, such as (poly)arthritis or necrosis of subcutaneous fat. A combination of pancreatitis, panniculitis and (poly)arthritis is referred to as the PPP syndrome, which is associated with acute and chronic pancreatitis, as well as pancreatic malignancies.

Case Description: This article describes a patient which was admitted to our hospital with severe polyarthritis and panniculitis. Read More

Ann Dermatol 2020 Jun 24;32(3):230-232. Epub 2020 Apr 24.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.

Exenatide extended-release was recently developed as an antidiabetic drug; it acts as a glucagon-like peptide-1 receptor agonist. A 54-year-old male visited our clinic complaining of a subcutaneous tender nodule on his left thigh that had developed over the course of 1 week. The patient had received exenatide extended-release injections for 5 months to treat diabetes. Read More

Semin Arthritis Rheum 2021 Apr 19;51(3):559-564. Epub 2021 Apr 19.

Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, and Hacettepe University Vasculitis Research Center, Ankara, 06100, Turkey. Electronic address:

Background: Diagnosis of childhood polyarteritis nodosa (PAN) has become challenging after the definition of deficiency of adenosine deaminase 2 (DADA2). We aimed to define the differential features of pediatric PAN and DADA2 patients in our center and in the literature.

Methods: The charts of pediatric PAN and DADA2 patients followed at the Pediatric Rheumatology Unit of Hacettepe University between 2010-2020 were analyzed. Read More

J Cutan Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Loyola University Medical Center, Maywood, Illinois.

While drug-induced panniculitis is not uncommon in chronic myeloid leukemia (CML) patients on tyrosine kinase inhibitor therapy, it is rare for CML to initially present as a leukemic panniculitis. We present the case of a 45-year-old male with no relevant prior medical history presenting with six months of migratory nodules, two months of drenching night sweats, and a 20 pound weight loss. Physical examination showed firm subcutaneous nodules with overlying ecchymoses present on the right lateral thigh and left lower back. Read More

Ital J Dermatol Venerol 2021 Apr 23. Epub 2021 Apr 23.

Dermatology Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.

Vet Pathol 2021 Apr 20:3009858211002190. Epub 2021 Apr 20.

Vet Med Labor GmbH, Kornwestheim, Germany.

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Read More

Indian J Dermatol Venereol Leprol 2021 Apr 12:1-5. Epub 2021 Apr 12.

Department of Dermatologic Surgery, Dermatologic Institute of Jalisco Dr. José Barba Rubio, Guadalajara, Mexico.

We report the clinical and histopathological features of hydroa vacciniforme-like lymphoproliferative disorder in five indigenous and Mestizo children. All the children resided at higher altitudes, experiencing maximal solar exposure. All cases presented with prurigo along with Epstein-Barr virus infection. Read More

Pediatr Dermatol 2021 Mar;38(2):e12-e13

Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Front Pediatr 2021 31;9:631329. Epub 2021 Mar 31.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Notable advances in gene sequencing methods in recent years have permitted enormous progress in the phenotypic and genotypic characterization of autoinflammatory syndromes. Interferonopathies are a recent group of inherited autoinflammatory diseases, characterized by a dysregulation of the interferon pathway, leading to constitutive upregulation of its activation mechanisms or downregulation of negative regulatory systems. They are clinically heterogeneous, but some peculiar clinical features may lead to suspicion: a familial "idiopathic" juvenile arthritis resistant to conventional treatments, an early necrotizing vasculitis, a non-infectious interstitial lung disease, and a panniculitis associated or not with a lipodystrophy may represent the "interferon alarm bells. Read More

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Dermatology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Claude Bernard Lyon I University, Lyon.

Report _Case Presentation X Photo Vignette _Letter Authors declare that the contents of this article are their own original unpublished findings. Title: Cutaneous calciphylaxis of the glans penis presenting as a gangrenous ulceration Authors: Marie Danset, Cécile Lesort, Denis Jullien, Jean Kanitakis Affiliations: Dermatology Department, Edouard Herriot Hospital, Hospices Civils de Lyon, Claude Bernard Lyon I University, Lyon, France Corresponding Author: Jean Kanitakis, Department of Dermatology, Edouard Herriot Hospital Group, 69437 Lyon Cedex 03, France, Tel: 33-472110301, Email: jean.kanitakis@univ-lyon1. Read More

North Clin Istanb 2021 25;8(2):186. Epub 2021 Feb 25.

Department of Gastroenterology, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211009342

Department of Central Laboratory, The First Hospital of Lanzhou University, Lanzhou, China.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma composed of CD8 cytotoxic T-cell that is primarily localized in the subcutaneous tissue. No standard treatments are currently available for SPTCL due to its rarity. Chemotherapy, radiotherapy, immunosuppressive agents, and hematopoietic stem cell transplantation (HSCT) have been used frequently, however, the effects of these treatment approaches remain controversial. Read More

Ann Transl Med 2021 Mar;9(5):436

Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA.

Dermatomyositis (DM) is a strikingly heterogenous disease characterized by a broad and ever-evolving spectrum of cutaneous manifestations that transcend the classic "hallmarks" defined by Peter and Bohan in 1975. Despite the increasing preponderance and ubiquity of autoantibody, radiologic, and electrophysiologic testing, the diagnosis of DM still hinges largely on prompt detection of cutaneous manifestations of this condition. While pathognomonic cutaneous features of DM are more readily recognizable, many patients present with subtle and/or atypical skin manifestations, and diagnosis of DM may require clinician identification of these cutaneous clues. Read More

Front Oncol 2021 18;11:611580. Epub 2021 Mar 18.

Department of Hematology and Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a malignant primary T-cell lymphoma that is challenging to distinguish from autoimmune disorders and reactive panniculitides. Delay in diagnosis and a high misdiagnosis rate affect the prognosis and survival of patients. The difficulty of diagnosis is mainly due to an incomplete understanding of disease pathogenesis. Read More

Int Med Case Rep J 2021 26;14:187-190. Epub 2021 Mar 26.

Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. The clinical presentation varies from asymptomatic cases to acute abdomen. The diagnosis is suggested by imaging but can be definitely established only by biopsies. Read More

Mycopathologia 2021 Apr 3. Epub 2021 Apr 3.

Department of Dermatology and Venerology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Disseminated cryptococcosis primarily affects immunosuppressed patients and has a poor outcome if diagnosis and treatment are delayed. Skin lesions are rarely manifest causing misdiagnosis. We present a case of cryptococcal cellulitis with severe pain in a kidney transplant recipient on long-term immunosuppressive therapy. Read More

Clin Rheumatol 2021 Apr 4. Epub 2021 Apr 4.

Department of Rheumatology, Boston University/Boston Medical Center, 725 Albany Street, Boston, MA, 02118, USA.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting not only the synovial joints but also multiple extra-articular sites, including ankle and foot soft tissue. Hindfoot abnormalities usually follow those in the forefoot, with up to 4 out of 10 patients experiencing talalgia during their disease course. Enthesophytosis, retrocalcaneal bursitis, and plantar fasciitis are among the most common etiologies, while heel fat pad abnormalities like subcalcaneal bursitis are rare. Read More

GE Port J Gastroenterol 2021 Feb 11;28(2):139-143. Epub 2020 Jun 11.

Internal Medicine Department, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal.

Introduction: Intra-abdominal fat is a metabolically active tissue that can undergo necrosis due to torsion, infarction, or trauma. Despite being asymptomatic in most cases, fat necrosis or steatonecrosis can cause abdominal pain. . Read More

Clin Cosmet Investig Dermatol 2021 25;14:303-312. Epub 2021 Mar 25.

Department of Rheumatology, Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Giant cell arteritis (GCA) is characterized by granulomatous inflammation of large and medium-sized vessels. It is the most common vasculitis among elderly people in Europe and North America. GCA usually presents with ischemic cranial manifestations such as headache, scalp tenderness, visual manifestations, and claudication of the tongue and jaw. Read More

Pediatr Blood Cancer 2021 Mar 31:e29035. Epub 2021 Mar 31.

Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.

Mod Rheumatol Case Rep 2021 Apr 15:1-7. Epub 2021 Apr 15.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

A 43-year-old-woman admitted to our department because of abdominal pain, abdominal distension, pain on both inner thighs and blurred vision lasting for 3 months. Pancytopenia and positive anti-double stranded DNA (dsDNA) antibodies were noted 5 years prior to her hospitalisation. On admission, the patient was diagnosed with systemic lupus erythematosus (SLE) with retinal vasculitis, panniculitis, cholecystitis and enteritis. Read More

Cureus 2021 Feb 20;13(2):e13460. Epub 2021 Feb 20.

Dermatology, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific, Pomona, USA.

We present a 57-year-old female with a past medical history of rheumatoid arthritis, hypertension, and hypothyroidism who presented with poorly demarcated, nonblanching, painful, erythematous nodules on the bilateral lower legs for two weeks. The patient recently switched from infliximab to abatacept infusions, and skin eruptions presented 53 days from her initial abatacept infusion. A 5 mm punch biopsy of the left anterior upper leg in the zone of involvement showed a deep dermal granulomatous infiltrate with associated eosinophils and a vaguely horizontally palisaded pattern with necrobiosis. Read More

J Am Acad Dermatol 2021 Mar 26. Epub 2021 Mar 26.

Department of Dermatology, Mayo Clinic, Jacksonville, Florida. Electronic address:

Clin J Gastroenterol 2021 Mar 24. Epub 2021 Mar 24.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Tohoku University Hospital, 1-1, Seiryo-Cho, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan.

A 66-year-old man with a history of diabetes and dilated cardiomyopathy underwent the implantation of a ventricular assist device (VAD) at the age of 62. He suffered from epigastralgia for a month and then visited our hospital with complaints of severe epigastralgia and hematemesis. A physical examination revealed abdominal distension without rigidity. Read More

Rev Soc Bras Med Trop 2021 22;54:e0269-2020. Epub 2021 Mar 22.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Dermatologia, São Paulo, SP, Brasil.

Reactivation of chronic Trypanosoma cruzi infection in solid organ transplant recipients (SOTRs) has been reported. The patient presented with a 2-week history of two painful erythematous, infiltrated plaques with central ulceration and necrotic crust on the left thigh. She had a history of chronic indeterminate Chagas disease (CD) and had received a kidney transplant before 2 months. Read More

Cancer Treat Res Commun 2021 Mar 17;27:100357. Epub 2021 Mar 17.

Department of Internal Medicine, University of Nevada Reno School of Medicine, Reno, NV, United States; Cancer Care Specialists, Reno, NV, United States.

Ponatinib is a tyrosine kinase inhibitor (TKI) approved for the treatment of Philadelphia chromosome-positive chronic myelogenous leukemia and acute lymphoblastic leukemia. Common adverse effects of ponatinib include neutropenia, arterial thrombosis, and hypertension. We describe a 49-year-old woman who developed panniculitis after brief treatment with ponatinib. Read More

J Travel Med 2021 Mar 20. Epub 2021 Mar 20.

Department of Infectious and Tropical Diseases, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.

Gnathostomiasis is a foodborne parasitic zoonosis known to be endemic in Southeast Asia, India, Central and South America, with recent cases reported in Zambia, Botswana and South Africa. We report a case of gnathostomiasis acquired in Madagascar and alert clinicians of the emerging risk in southern Africa. Read More

World J Clin Cases 2021 Mar;9(8):1885-1892

Department of Anesthesiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) involvement in the central nervous system (CNS) is particularly rare. SPTCL with CNS involvement has an exceedingly poor prognosis, and no optimum therapeutic method has been discovered. To the best of our knowledge, this is the first reported case of SPTCL invading the CNS achieving long-term remission with lenalidomide maintenance therapy. Read More