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    Clues in Histopathological Diagnosis of Panniculitis.
    Am J Dermatopathol 2018 Mar;40(3):155-167
    Head of Surgical Pathology, Pathology Department, Hospital Univeristari General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.
    Background: Panniculitides comprise a group of heterogeneous inflammatory diseases. Nevertheless, histopathological study along with clinicopathological correlation usually led to a specific diagnosis. In most textbooks, the first step in the diagnosis is to classify them as mostly septal or lobular depending on where the inflammatory infiltrate is located. Read More

    Lesiones subcutáneas dolorosas en paciente con melanoma metastásico: un caso de paniculitis linfocítica asociado a vemurafenib.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Department of Dermatology, Dermatologist, Hospital Universitario Doctor Peset, Valencia, Spain.
    Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. Read More

    Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman.
    Indian Dermatol Online J 2018 Jan-Feb;9(1):47-49
    Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.
    Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype consisting of skin ulceration among other signs. Read More

    Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients.
    J Immunother Cancer 2018 Feb 12;6(1):14. Epub 2018 Feb 12.
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobullous disorders, lichenoid dermatitis, and vitiligo. Read More

    Histological and Immunological Description of the Leishmanin Skin Test in Ibizan Hounds.
    J Comp Pathol 2018 Jan 4;158:56-65. Epub 2018 Jan 4.
    Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain; Hospital MonVeterinari, Manacor, Mallorca, Spain. Electronic address:
    The leishmanin skin test (LST), a delayed-type hypersensitivity (DTH) reaction to Leishmania infantum, can specifically identify dogs that have made a cell-mediated immune response to L. infantum infection. The Ibizan hound appears to be more resistant to L. Read More

    Safety, tolerability, and efficacy evaluation of the SlimME device for circumference reduction.
    Lasers Surg Med 2018 Feb 7. Epub 2018 Feb 7.
    Queen Anne Street Medical Centre, 18-22 Queen Anne St, Marylebone W1G 8HU, London.
    Objective: To assess the short- and long-term thermal impact of subclinical and clinical regimens of a single, non-invasive uniform ultrasound treatment session on subcutaneous adipose tissue (SAT).

    Study Design: Prospective, open-label, single-arm, split-side study.

    Methods: Patients (n = 17) were subjected to uniform ultrasound treatment, delivered in a single session with the SlimME device. Read More

    [Dermatological features of auto-inflammatory recurrent fevers].
    Arch Pediatr 2018 Feb 1;25(2):150-162. Epub 2018 Feb 1.
    Université Paris-Saclay, university Paris-Sud, CHU de Bicêtre, 78, avenue du Général-Leclerc, Le-Kremlin-Bicêtre, France.
    Auto-inflammatory diseases are characterized by unexplained and recurrent attacks of systemic inflammation often involving the skin, joints, or serosal membranes. They are due to a dysfunction or dysregulation of the innate immunity, which is the first line of defense against pathogens. Early recognition of these diseases by the clinician, especially by pediatricians encountering such pathologies in pediatric patients, is primordial to avoid complications. Read More

    Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9237
    Division of Gastroenterology and Hepatology, Department of Internal Medicine.
    Rationale: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. Read More

    Acute myeloid leukemia presenting as erythema nodosum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8666
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Rationale: Erythema nodosum (EN), a type of septal panniculitis, could be a rare nonspecific cutaneous presentation of acute myeloid leukemia (AML).

    Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Read More

    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Unit Ospedale Carlo Urbai Jesi, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet's syndrome, neutrophilic dermatosis of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

    Cutaneous lupus erythematosus: clinico-pathologic correlation.
    G Ital Dermatol Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Dermatology Unit, "A. Perrino" Hospital, Brindisi, Italy.
    Cutaneous lupus erythematosus (CLE) is a chronic-relapsing disease. It is defined as a LE localized to the skin without any significant systemic symptoms. Its annual incidence is of 4 cases per 100,000 persons with a prevalence of 73 cases per 100,000 persons. Read More

    Acute kidney injury due to multiple Hymenoptera stings-a clinicopathological study.
    Clin Kidney J 2017 Aug 28;10(4):532-538. Epub 2017 Mar 28.
    Community Medicine, Indira Gandhi Medial College, Shimla, Himachal Pradesh, India.
    Background: Acute kidney injury (AKI) after multiple Hymenoptera stings is well known but still a rare phenomenon.

    Methods: We conducted a retrospective study of the clinicopathological spectrum of AKI due to multiple Hymenoptera stings over 13 years (July 2003-June 2016).

    Results: A total of 35 patients were diagnosed with AKI due to multiple Hymenoptera stings. Read More

    Mesenteric Panniculitis-First Case Series After Bariatric Surgery.
    Obes Surg 2018 Mar;28(3):881-885
    Bariatric and Metabolic Surgery, Wockhardt Hospitals, Mumbai, India.
    Mesenteric panniculitis is an uncommon pathology, of poorly understood etiology, characterized by progressive inflammation and fibrosis of the small bowel mesentery. This disease has been reported usually after other abdominal surgeries. We present two cases of young male patients who underwent laparoscopic sleeve gastrectomy and developed abdominal symptoms within 45-60 days of surgery. Read More

    Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients.
    BMC Gastroenterol 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, I.R.C.C.S. Fondazione Cà Granda, Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
    Background: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. Read More

    An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions.
    Am J Case Rep 2018 Jan 4;19:13-20. Epub 2018 Jan 4.
    Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.
    BACKGROUND Mesenteric panniculitis (MP) is an idiopathic chronic inflammatory condition of the mesentery. The main symptoms include abdominal pain, abdominal distention, weight loss, fever, nausea, and vomiting. The patients also present with chylous ascites in 14% of the cases and chylous pleural effusion (CPE) in very rare occasions. Read More

    Septolobular panniculitis in disseminated Lyme borreliosis.
    J Cutan Pathol 2018 Jan 2. Epub 2018 Jan 2.
    Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

    Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
    Biochem Biophys Res Commun 2018 01 28;495(4):2616-2621. Epub 2017 Dec 28.
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
    Sleep disturbances are associated with various metabolic diseases such as hypertension and diabetes. We had previously established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by disrupted circadian rhythms of wheel-running activity, core body temperature, and sleep-wake cycles. To evaluate the underlying mechanisms of metabolic disorders induced by CSD, we created mice with CSD for six weeks and fed them with a high-fat diet. Read More

    Panniculitis in the setting of dermato/rheumatologic diseases.
    G Ital Dermatol Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Unit of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Panniculitides represent a heterogeneous group of inflammatory diseases that are traditionally considered one of the most difficult challenge for clinicians and pathologists. They may occur in a variety of dermato/rheumatologic diseases and are of particular relevance for clinicians dealing with such pathologies, including immune-mediated/autoimmune and autoinflammatory disorders. In fact, panniculitides can be the initial sign of presentation of a dermato/rheumatologic disease, thereby providing the physician with important clues to the correct diagnosis. Read More

    Successful treatment of erythema induratum with topical application of antituberculous drugs: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9010
    Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Erythema induratum, a chronic recurrent lobular panniculitis with vasculitis, is strongly associated with Mycobacterium tuberculosis infection. The recommended drugs include isoniazid, rifampicin, and pyrazinamide, which are typically administered in combination (orally or intravenously). Till date, there are no reports about topical application of anti-tuberculous (anti-TB) drugs for treatment of erythema induratum. Read More

    Compression stockings as an effective treatment for erythema nodosum: Case series.
    Int J Womens Dermatol 2017 Dec 29;3(4):231-233. Epub 2017 Sep 29.
    Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ.
    Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. Read More

    Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features.
    J Am Acad Dermatol 2017 Dec 9. Epub 2017 Dec 9.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Melanoma differentiation-associated gene 5 (MDA5) is a recently described autoantigen target in a subset of patients with dermatomyositis. Anti-MDA5 dermatomyositis is characterized by a unique mucocutaneous and systemic phenotype that includes cutaneous and oral ulceration, painful palmar papules, alopecia, panniculitis, arthritis, a lower incidence of myositis, and, importantly, an elevated risk of interstitial lung disease with a potentially fatal course. Because the clinical features can differ substantially from those typically observed in cutaneous dermatomyositis, the diagnosis is often overlooked, which might negatively affect patient outcomes. Read More

    Diagnosing alpha-1 antitrypsin deficiency: the first step in precision medicine.
    F1000Res 2017 27;6:2049. Epub 2017 Nov 27.
    Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave., Boston, MA, 02115, USA.
    Severe alpha-1 antitrypsin (AAT) deficiency is one of the most common serious genetic diseases in adults of European descent. Individuals with AAT deficiency have a greatly increased risk for emphysema and liver disease. Other manifestations include bronchiectasis, necrotizing panniculitis and granulomatosis with polyangiitis. Read More

    [Misty mesentery : Mesenteric panniculitis and associated processes].
    Radiologe 2018 Jan;58(1):56-59
    Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
    Background: Sclerosing mesenteritis (SM) and mesenteric panniculitis are rare processes of the mesentery which pose a major clinical and imaging challenge. This review article attempts to introduce a systematic nomenclature to address typical symptoms, imaging and major differential diagnoses.

    Results: SM with its subtypes-mesenteric lipodystrophy, panniculitis and retractile mesenteritis-is a chronic process with a very diverse and heterogeneous clinical appearance. Read More

    Subcutaneous granuloma annulare involving the scalp.
    Pediatr Dermatol 2018 Jan 4;35(1):e72-e73. Epub 2017 Dec 4.
    Department of Dermatology, Boston Children's Hospital, Boston, MA, USA.
    Subcutaneous granuloma annulare (SGA) is an uncommon subtype of granuloma annulare. There are few reports of this entity solely affecting the scalp. We report a case of biopsy-proven SGA in a 21-month-old boy with six asymptomatic, rock-hard scalp nodules. Read More

    Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.
    Immunol Res 2018 Feb;66(1):120-140
    Europe Medical Centre, Barcelona, Spain.
    Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Read More

    Endothelial microparticles-mediated transfer of microRNA-19b promotes atherosclerosis via activating perivascular adipose tissue inflammation in apoEmice.
    Biochem Biophys Res Commun 2018 01 2;495(2):1922-1929. Epub 2017 Dec 2.
    Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China; Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, 100044, China; Center for Cardiovascular Translational Research, Peking University People' s Hospital, Beijing, 100044, China. Electronic address:
    Microparticles(MPs) are the major carriers of circulating microRNAs. Our previous study has shown that microRNA (miR)-19b in endothelial cell-derived microparticles (EMPs) is significantly increased in patients with unstable angina. However, little is known about the relationship between miR-19b in EMPs and the progression of atherosclerosis. Read More

    Eosinophilic granulomatosis with polyangiitis without respiratory symptoms or asthma in an adolescent: case report and literature review.
    Rheumatol Int 2017 Nov 30. Epub 2017 Nov 30.
    Department of Pediatric Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey.
    Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a systemic necrotizing vasculitis of the small and medium vessels. It is primarily associated with respiratory conditions such as asthma and sinusitis as well as eosinophilia, neuropathy, pulmonary infiltrates, and vasculitis. EGPA is extremely rare in the pediatric age group, and respiratory system disorders are usually predominant in EGPA patients. Read More

    Lymphoma Involving Skin and Subcutaneous Fat of the Breast: Two Cases.
    Ultrasound Q 2017 Dec;33(4):276-280
    Breast lymphoma is uncommon, and it usually involves breast parenchyma and ipsilateral axillary lymph nodes. We report rare cases of cutaneous T-cell lymphoma involving the skin and subcutaneous fat layers mimicking panniculitis of the breasts in a 33-year-old male patient who presented with a growing palpable mass and pain in both breasts and in 17-year-old female patient who presented with an indolent palpable breast mass for 1 year. Extranodal natural killer/T-cell nasal-type and subcutaneous panniculitis-like T-cell lymphomas were diagnosed after skin punch biopsies. Read More

    [A case report of subcutaneous panniculitis-like T cell lymphoma with fever and erythema on the body as the initial symptoms].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Nov;42(11):1348-1352
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
    Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a very rare form of peripheral α/β T cell skin lymphoma that is localized primarily in the subcutaneous adipose tissues. It is characterized by single or multiple painful subcutaneous nodules or lumps, often affecting the limbs. The patient presented to the Department of Dermatology, Second Xiangya Hospital, Central South University, who suffered from intermittent fever and erythema on the body, finally was diagnosed as SPTCL after histopathological examinations for twice. Read More

    Incidence and ten-year follow-up of primary cutaneous lymphomas: a single-centre cohort study.
    Eur J Dermatol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
    Background: Primary cutaneous lymphomas (PCLs) are a rare group of extranodal non-Hodgkin lymphomas, and epidemiological data in Mediterranean countries are scarce.

    Objective: To investigate the incidence and characteristics of PCL in a single tertiary referral centre in Italy.

    Materials & Methods: A total of 141 PCL patients, seen over a 10-year follow-up period, were investigated. Read More

    Severe panniculitis and polyarthritis caused by acinar cell carcinoma arising from an ectopic pancreas.
    BMJ Case Rep 2017 Nov 21;2017. Epub 2017 Nov 21.
    Department of Pathology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
    The pancreatitis, panniculitis and polyarthritis (PPP) syndrome is a rare condition caused by pancreatic diseases, such as acute or chronic pancreatitis or pancreatic carcinoma. We report the first case of PPP syndrome caused by metastatic acinar cell carcinoma from an ectopic pancreas. The symptoms were successfully managed by the treatment of the metastatic carcinoma. Read More

    Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis.
    Vet Pathol 2018 Jan 16;55(1):124-132. Epub 2017 Nov 16.
    1 Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
    Next generation sequencing (NGS) studies are revealing a diverse microbiota on the skin of dogs. The skin microbiota of canine sterile granulomatous and pyogranulomatous dermatitis (SGPD) has yet to be investigated using NGS techniques. NGS targeting the 16S rRNA and ITS-1 region of bacterial and fungal DNA, respectively, were used to investigate if bacterial and fungal DNA were associated with skin lesions in cases of canine SGPD. Read More

    Paradoxical Adipose Hypertrophy (PAH) After Cryolipolysis.
    Aesthet Surg J 2017 Nov 14. Epub 2017 Nov 14.
    Plastic and Aesthetic Surgery Department, Hopital Tenon, Paris, France. Private practice, Paris, France. Department of Dermatology, Hopital Tenon, Paris, France. Anatomopathology Laboratory, Hopital Tenon, Paris, France.
    Background: Cryolipolysis is a minimally invasive technique used to decrease local adipose tissue by thermal cooling. Paradoxical adipose hypertrophy (PAH) is a rare complication of cryolipolysis with important aesthetic consequences.

    Objectives: The objective of this study was to describe four cases of PAH after a cryolipolysis treatment. Read More

    Sclerosing mesenteritis diagnosed with computed tomography and ultrasound-guided needle biopsy: the utility of the coaxial technique.
    Clin J Gastroenterol 2018 Feb 16;11(1):92-95. Epub 2017 Nov 16.
    Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.
    Here we report a case of sclerosing mesenteritis that we diagnosed with needle biopsy under the guidance of computed tomography (CT) and ultrasound (US) observation. An 82-year-old woman presented with appetite loss, weight loss and epigastric pain. CT of the abdomen and pelvis revealed increased density of the mesentery adjacent to the small bowel and enlarged lymph nodes. Read More

    Post-irradiation morphoea of the breast: a case report and review of the literature.
    Histopathology 2018 Jan 7;72(2):342-350. Epub 2017 Nov 7.
    Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
    We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Read More

    Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.
    Clin Sci (Lond) 2017 Dec 4;131(24):2885-2900. Epub 2017 Dec 4.
    Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously, we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. Read More

    Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child.
    European J Pediatr Surg Rep 2017 Jan 28;5(1):e68-e70. Epub 2017 Oct 28.
    Department of Pediatrics, Hematology and Oncology, Pomorski Uniwersytet Medyczny w Szczecinie, Szczecin, Poland.
    During infancy, skin inflammation is usually treated in basic pediatric care. In this study, we present a case of an 8-month-old girl with a 2-month history of an inflammation of the thigh treated locally by ointments and oral antibiotics in basic and dermatological care. The patient had a history of fever, sweating, and failure to thrive. Read More

    An Unexpected Etiology of Pancreatic Panniculitis: A Case Report.
    J Pancreat Cancer 2017 1;3(1):1-4. Epub 2017 Jan 1.
    Division of Gastroenterology and Hepatology, University of Pittsburgh School of Medicine, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213.
    Background: Pancreatic panniculitis is a rare cause of subcutaneous fat necrosis secondary to elevated serum levels of pancreatic enzymes. It is most often associated with pancreatic acinar cell carcinoma, but has also been seen in patients with pancreatitis.

    Case Report: We present a case of a 64 year old Caucasian man without symptoms of pancreatitis who presents with pancreatic panniculitis manifesting in multiple subcutaneous ulcerating nodules of the bilateral lower extremities, discovered to have a previously unreported etiology for this condition. Read More

    Sterile nodular panniculitis with lung and lymph node involvement in a Siberian tiger (Panthera tigris altica).
    J Vet Med Sci 2017 Dec 30;79(12):1998-2001. Epub 2017 Oct 30.
    State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 678 Haping Road, Harbin 150069, People's Republic of China.
    A 2- to 4-year-old uncastrated male Siberian tiger (Panthera tigris altica) bred in a local wild animal park presented with generalized clinical signs including abdominal pain, fever, lethargy, and anorexia, along with subcutaneous nodules along the trunk. The patient subsequently died of chronic, progressive dyspnea despite 45 days of antibiotic treatment. At necropsy, mesenteric fat inflammation and multiple subcutaneous, peritoneal, and intraabdominal nodules were observed. Read More

    An Overlooked Potentially Treatable Disorder: Idiopathic Mesenteric Panniculitis.
    Med Princ Pract 2017 Oct 26. Epub 2017 Oct 26.
    Objective: The aim of this study was to determine the prevalence of mesenteric panniculitis (MP) and to describe its clinical characteristics, therapy and outcome.

    Subjects And Methods: This retrospective study was carried out among patients defined as MP according to computed tomography (CT) scans from January 2012 to December 2015. The CT images were reanalyzed by study radiologists to confirm the previous MP diagnosis. Read More

    Primary Cutaneous Acral CD8T-Cell Lymphoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1469-1475
    From the Sections of Hematopathology (Drs Hathuc and Smith) and Dermatopathology (Dr Hristov) in the Department of Pathology, University of Michigan Medical Center, Ann Arbor.
    Primary cutaneous acral CD8T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8T-cell lymphomas. Read More

    Self-healing juvenile cutaneous mucinosis: Clinical and histopathologic findings of 9 patients: The relevance of long-term follow-up.
    J Am Acad Dermatol 2017 Oct 21. Epub 2017 Oct 21.
    Department of Dermatology, Centre National de Référence des Maladies Génétiques à Expression Cutanée (MAGEC), Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France; Unité INSERM U 1163, University Paris-Descartes; Institut Imagine, Sorbonne Cité University, Paris, France.
    Background: Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder, and its pathogenesis and long-term prognosis are unknown.

    Objective: To elucidate the clinical and histopathologic characteristics, pathogenesis, and outcome in patients with SHJCM.

    Methods: Retrospective study of 9 patients with SHCJM. Read More

    Inflammation and Fibrosis in Perirenal Adipose Tissue of Patients With Aldosterone-Producing Adenoma.
    Endocrinology 2018 01;159(1):227-237
    Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    The prevalence of primary aldosteronism is much higher than previously thought. Recent studies have shown that primary aldosteronism is related to a higher risk of cardiovascular events. However, the underlying mechanism is not yet clear. Read More

    Orbital T-cell lymphoma versus lupus panniculitits: a T-cell-mediated spectrum of orbital lymphoproliferative disease.
    Orbit 2017 Oct 17:1-3. Epub 2017 Oct 17.
    b The Oculoplastic and Orbital Surgery Department of Wills Eye Hospital , Thomas Jefferson University Hospital , Philadelphia , PA , USA.
    This is a case description of a single male patient found to have T-cell-mediated inflammation and lymphoproliferation of the orbit. Chronic T-cell-mediated inflammatory disease can pose a diagnostic challenge particularly in its differentiation from a neoplastic process. The histopathology in this case demonstrated features of both lupus erythematosus panniculitis and features of orbital T-cell lymphoma. Read More

    Cold-Induced Dermatoses: Case Report and Review of Literature.
    Am J Dermatopathol 2017 Sep 27. Epub 2017 Sep 27.
    *Department of Anatomic Pathology, University Hospital Jose Eleuterio Gonzalez, Monterrey, Mexico; †Department of Dermatology, West Virginia University, Morgantown, WV; and ‡Department of Pathology, West Virginia University, Morgantown, WV.
    Cold panniculitis and perniosis are the most common cold-induced dermatologic disorders and are clinically characterized by indurated and erythematous nodules and plaques that develop at sites exposed to excessive cold and wet conditions. Cold panniculitis is most commonly seen in infants, but adult cases involving the thighs of equestrians are well known and have come to be known as equestrian cold panniculitis or equestrian perniosis. Recently, similar cases have been described in nonequestrian settings with the prolonged use of ice-packs or other cold-therapy devices. Read More

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