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An Bras Dermatol 2018 Jun;93(3):412-414

Department of Pathology, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Subcutaneous fat necrosis of the newborn is a rare benign panniculitis found in term and post-term neonates. Diagnosis is based on clinical characteristics and specific alterations in the adipocytes, detected by anatomical pathology. Subcutaneous fat necrosis of the newborn can occur in uncomplicated pregnancy and childbirth. Read More

Saudi Med J 2018 Jun;39(6):622-626

Department of Pediatric, Section of Pediatric Critical Care, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life threatening levels. Read More

Rev Med Interne 2018 Jun 15. Epub 2018 Jun 15.

Inserm U1096, département de médecine interne, Normandie université UNIROUEN, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France.

Turk J Med Sci 2018 Jun 14;48(3):569-575. Epub 2018 Jun 14.

Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Read More

Exp Ther Med 2018 Jun 25;15(6):5523-5527. Epub 2018 Apr 25.

Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China.

Panniculitis is a group of heterogeneous disorders characterized by inflammation of the subcutaneous adipose tissue. Panniculitis of breast tissue as the initial manifestation has rarely been reported and is often misdiagnosed. Breast panniculitis may cause substantial morbidity and early diagnosis and treatment are important for the prognosis of the disease. Read More

Vet Clin Pathol 2018 Jun;47(2):307-311

Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Dirofilaria repens is an endemic, zoonotic parasite of carnivores, causing subcutaneous dirofilariasis, which is mostly asymptomatic. The aim of this study was to describe 22 cases of canine subcutaneous dirofilariasis. The cytologic and histopathologic samples were collected from dogs, which presented with various clinical signs such as cutaneous/subcutaneous nodules, hydropericardium, ascites, and lymphadenomegaly. Read More

Histopathology 2018 Jun 12. Epub 2018 Jun 12.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Aims: The diagnosis of cutaneous gamma delta T-cell lymphoma (GDTCL) requires the identification of γδ chains of the T-cell receptor (TCR). Using a new mAb to TCRδ, we evaluated TCRδ expression in formalin fixed paraffin embedded (FFPE) skin tissue from TCRγ-positive cutaneous T-cell lymphoma (CTCL) and assessed TCRδ expression within a spectrum of other cutaneous lymphoproliferative disorders (CLPD).

Methods And Results: 12 cases (10 patients) with TCRγ-positive CTCL and 132 additional CLPD cases (127 patients) were examined including mycosis fungoides (MF, n=60), cutaneous GDTCL (n=15), subcutaneous panniculitis-like T-cell lymphomas (SPTCL, n=11), and CD30+ lymphoproliferative disorders (CD30+LPDs, n=24). Read More

JAAD Case Rep 2018 Mar 4;4(2):179-184. Epub 2018 Feb 4.

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Acta Derm Venereol 2018 Jun;98(6):610-611

Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Mycopathologia 2018 Jun 6. Epub 2018 Jun 6.

Instituto Nacional de Investigación Agropecuaria (INIA), Ruta No. 50, km 11, La Estanzuela, Colonia, 70006, Uruguay.

Protothecosis is a rare disease caused by environmental algae of the genus Prototheca. These are saprophytic, non-photosynthetic, aerobic, colorless algae that belong to the Chlorellaceae family. Seven different species have been described. Read More

Int J Womens Dermatol 2018 Mar 21;4(1):23-26. Epub 2017 Oct 21.

Massachusetts General Hospital, Boston, MA.

Case Rep Dermatol 2018 May-Aug;10(2):110-114. Epub 2018 May 4.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. Read More

Actas Dermosifiliogr 2018 May 30. Epub 2018 May 30.

Servicio de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España.

Reumatologia 2018 9;56(2):111-120. Epub 2018 May 9.

Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Rheumatoid arthritis (RA), which is a chronic inflammatory disease with a multifactorial aetiology, leads to partial or permanent disability in the majority of patients. It is characterised by persistent synovitis and formation of pannus, i.e. Read More

Medicine (Baltimore) 2018 Jun;97(22):e10911

Pancreas Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.

Rationale: Pancreatic pseudocyst can present single or multiple, inside or outside the pancreas. Pancreatic panniculitis is a rare skin lesion in pancreatic disease patients. The purpose of this study is to report a case of chronic pancreatitis coexisting with multiple pseudocysts and pancreatic panniculitis. Read More

J Cutan Pathol 2018 May 30. Epub 2018 May 30.

Département de Pathologie, CHU Nîmes, Nîmes, France.

Composite lymphoma (CL) is a rare disease defined by the occurrence of 2 distinct lymphomas within a single tissue at the same time. We present the case of an 89-year-old male with a clinical history of immunoglobulin M monoclonal gammapathy of undetermined significance (IgM MGUS). The patient presented cutaneous eruption of nodules on the right bottom and arm. Read More

Parasitol Int 2018 May 23;67(5):597-600. Epub 2018 May 23.

School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia; Graham Centre for Agricultural Innovations, Wagga Wagga, NSW, Australia.

Tongue worms utilise herbivorous mammals as intermediate hosts and reside in the nasopharynx of carnivores as their definitive hosts. A recent study in south eastern Australia showed an unexpectedly high infection (67%) of wild dogs with these parasites. The present study aimed at determining the pathogenicity of the parasite in both definitive (dog) and intermediate (cattle) hosts by histopathology. Read More

Rev Chil Pediatr 2018 Apr 4;89(2):246-250. Epub 2018 Apr 4.

Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.

Introduction: Extranodal natural killer/T-cell lymphoma (NK/T), nasal type, is an infrequent neoplasm with a high lethality, characterized by bone destruction around the sinus, nasal septum or obstruction of the airway. Also, may be primary skin involvement, airway and other organs. Objecti ve: Submit a rare condition in the pediatric population, in order to facilitate the diagnostic suspicion and quick recognition from specialists. Read More

Reumatol Clin 2018 May 21. Epub 2018 May 21.

Servicio de Radiodiagnóstico, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Heterotopic ossification is an uncommon disorder that consists of deposition of ectopic bone outside the extraskeletal tissues. In the skin, it can be primary, in association with genetic syndromes, or be secondary to different disorders. The latter include subcutaneous ossification of the legs in chronic venousinsufficiency, an infrequent and unrecognized complication. Read More

Pediatr Dermatol 2018 May 16. Epub 2018 May 16.

Department of Dermatology, Columbia University, New York, NY, USA.

Indications for everolimus and other drugs within the mammalian target of rapamycin inhibitor class have recently expanded to include tuberous sclerosis complex. Everolimus is generally well tolerated, but it is important for physicians to identify and manage associated cutaneous adverse effects. We report the first case of a child developing erythema nodosum while undergoing everolimus therapy. Read More

Oxf Med Case Reports 2017 Aug 17;2017(8):omx041. Epub 2017 Aug 17.

Primary Care Health Center Schimatari, Primary, Care Health Unit, 5th Health Care District of Greece, Greece.

Erythema nodosum is a panniculitis associated with numerous diseases such as infections, inflammatory diseases, tuberculosis or can be idiopathic. We here report a case of a woman with erythema nodosum and reactive arthritis who was subsequently diagnosed with tuberculosis. A high level of suspicion and a thorough clinical and laboratory investigation of the patient presenting with erythema nodosum is required, in order to detect a possible systemic underlying condition. Read More

Am J Dermatopathol 2018 May 2. Epub 2018 May 2.

Departments of Pathology and Dermatology, University of California, San Francisco, CA.

The distinction between subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus (LE) panniculitis is remarkably challenging. Rimming by lymphocytes with an elevated Ki-67 cell proliferation index has been forwarded as a potential diagnostic finding in biopsies of SPTCL but has not been rigorously compared with biopsies from patients with LE panniculitis. Nineteen and 17 examples of SPTCL and LE panniculitis, respectively, were evaluated for periadipocytic rimming by lymphocytes expressing Ki-67, CD8, and βF1 and for attributes associated with LE, including clusters of CD123-positive cells. Read More

Australas J Dermatol 2018 May 9. Epub 2018 May 9.

Department of Dermatology, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Pancreatic panniculitis is a rare type that only occurs in 2-3% of all patients with pancreatic diseases. It is usually described in association with benign pancreatic disease and less commonly in association with pancreatic carcinoma. We describe a case of pancreatic panniculitis as the first manifestation of underlying ampullary adenocarcinoma and a new case of pancreatitis, panniculitis and polyarthritis (PPP-Syndrome). Read More

Skin Res Technol 2018 May 7. Epub 2018 May 7.

Department of Dermatology, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

Ann Indian Acad Neurol 2018 Jan-Mar;21(1):74-76

Institute of Neurology, Madras Medical College, Chennai, Tamil Nadu, India.

We report an unusual presentation in a 9-year-old girl with unilateral circumferential thinning of the entire right upper limb without any other neurological deficit, with normal nerve conduction and electromyography initially thought of as a neurodegenerative disorder based on clinical presentation. Magnetic resonance imaging of the upper limb showed partial lipoatrophy with normal glucose metabolism and lipid profile and negativity for HIV and autoimmune disease (panniculitis) with no family history of similar disorder. Remember to think out of box before labeling neurodegenerative disease. Read More

Dermatopathology (Basel) 2018 Jan-Mar;5(1):10-13. Epub 2018 Jan 23.

Department of Clinical and Surgical, Diagnostic and Pediatric Sciences, Dermatology Clinic, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy.

Int J Dermatol 2018 Apr 29. Epub 2018 Apr 29.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: Alpha-1 antitrypsin deficiency (AATD) may be associated with liver and lung disease and rarely causes panniculitis.

Objective: We evaluated the clinicopathologic and laboratory findings of AATD panniculitis in 10 patients.

Methods: We conducted a retrospective review of all cases of AATD panniculitis at Mayo Clinic, Rochester, MN, from 1989 to 2016. Read More

Pediatr Emerg Care 2018 Apr 25. Epub 2018 Apr 25.

From the Connecticut Children's Medical Center, Hartford, CT.

A late preterm infant presenting with supraventricular tachycardia (SVT) was admitted to the pediatric intensive care unit because of poor systolic function seen on echocardiogram. The hospitalization was complicated by multiple breakthrough episodes of SVT requiring ice placed on the face during each repeat episode. The infant was later diagnosed as having cold panniculitis secondary to the application of ice to the face on multiple occasions. Read More

JAAD Case Rep 2018 May 4;4(4):359-361. Epub 2018 Apr 4.

Icahn School of Medicine at Mount Sinai, New York, New York.

JAAD Case Rep 2018 May 1;4(4):344-345. Epub 2018 Apr 1.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Pediatr Dermatol 2018 Apr 25. Epub 2018 Apr 25.

Johnson & Johnson Santé Beauté France, Issy-les-Moulineaux, France.

Background/objectives: Infant skin undergoes a maturation process during the early years of life. Little is known about the skin's innate immunity. We investigated the dynamics of innate immunity markers collected from the surface of infant skin during the first 36 months of life. Read More

Case Rep Gastrointest Med 2018 29;2018:5658039. Epub 2018 Jan 29.

Rheumatology, Madigan Army Medical Center, Tacoma, WA, USA.

Mesenteric panniculitis is characterized by nonspecific fibrous inflammation of the small bowel mesentery, appendix, and mesoappendix. Clinical course is usually benign and outcome is favorable. We report a case of mesenteric panniculitis presenting as fever of unknown etiology in a patient with history of abdominal surgery. Read More

Dermatol Ther 2018 Apr 11:e12610. Epub 2018 Apr 11.

Department of Dermatology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.

Erythema nodosum migrans (subacute nodular migratory panniculitis) is an uncommon type of panniculitis characterized by migrating subcutaneous nodules or plaque on the lower extremity. There are a very few cases of Erythema nodosum migrans reported and thus its appropriate treatment modality is not defined. We describe a case of a 30-year-old male with idiopathic erythema nodosum migrans which was manifest centrifugally spreading, slightly morpheaform erythematous plaque on the lower left leg. Read More

An Bras Dermatol 2018 Jan-Feb;93(1):119-121

Department of Pathology, Faculdade de Medicina de Jundiaí (FMJ) - Jundiaí (SP), Brasil.

Panniculitis is a rare clinical finding in dermatomyositis, with less than 30 cases reported and there is only one case associated with the amyopathic subtype described in the literature. The present report describes a 49-year-old female patient that one year after being diagnosed with amyopathic dermatomyositis, presented indurated, painful, erythematous to violaceous nodules located on the upper limbs, thighs and gluteal region. Skin biopsy revealed lobular panniculitis with a lymphocytic infiltrate. Read More

Z Rheumatol 2018 May;77(4):309-321

Zentrum Innere Medizin, Medizinische Klinik und Poliklinik II, Rheumatologie/Klinische Immunologie, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.

Rheumatic paraneoplastic syndromes are paraneoplastic arthritis, palmar fasciitis and polyarthritis syndrome, remitting seronegative symmetrical synovitis with pitting edema, pancreatic panniculitis with polyarthritis, paraneoplastic vasculitis, cancer-associated myositis, hypertrophic osteoarthropathy (Marie-Bamberger disease) and tumor-induced osteomalacia. Typical clinical manifestations, pathogenesis, prognosis, and treatment of this entity are presented. Knowledge of these disease entities can lead to timely diagnosis of the underlying malignant disease and to a higher probability of a cure. Read More

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Dermatology Department, Hospital de Santarém EPE, Santarém, Portugal.

Subcutaneous fat necrosis of the newborn is an uncommon, transient, and self-healing panniculitis, mostly affecting term newborns with perinatal complications. The authors present a case of a female full-term neonate, born from an uncomplicated pregnancy, admitted into the neonatology unit 5 hours after delivery because of refractory multifocal seizures in the context of hypoxic-ischemic encephalopathy. Nine days after birth, indurated and erythematous nodules and plaques were noted on the left arm and back. Read More

Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.

Department of Dermatology,, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

J Inflamm Res 2018 26;11:123-134. Epub 2018 Mar 26.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

Alpha-1 antitrypsin (AAT) is the most abundant serine protease inhibitor circulating in the blood. AAT deficiency (AATD) is an autosomal codominant condition affecting an estimated 3.4 million individuals worldwide. Read More

Pediatrics 2018 Apr;141(Suppl 5):S496-S500

Institut Imagine, INSERM U1163.

We report on 4 children who presented with aseptic panniculitis associated with inherited immunodeficiency. Three patients had a B-cell immunodeficiency resulting from mutations in the and genes (no mutation was found in the third patient), and 1 had a T-cell deficiency (mutation in the gene). Panniculitis occurred before the age of 2 years in the 4 patients and preceded the onset of recurrent infections because of immunodeficiency in 2. Read More

Dermatopathology (Basel) 2018 Jan-Mar;5(1):30-33. Epub 2018 Feb 15.

UOC Dermatologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Abnormalities in alpha-1 antitrypsin (AAT) proteins are risk factors for human disease. While the most common is AAT deficiency, a genetic disorder associated with chronic obstructive pulmonary disease, additional disorders associated with AAT abnormalities are increasingly recognised. We describe a middle-aged woman who presented with fulminant hepatic and multiorgan failure. Read More

Pediatr Dermatol 2018 Mar;35(2):287-288

Division of Dermatology, Departments of Medicine and Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Singapore Med J 2018 03;59(3):163-164

Dermatology Unit, Singapore General Hospital, Singapore.

Cutis 2018 Jan;101(1):E34-E37

Midwest Center for Dermatology and Cosmetic Surgery, St. John Macomb-Oakland Hospital, Warren, Michigan, USA.

A rare triad composed of lobular panniculitis in the setting of pancreatitis and polyarthritis is termed panniculitis, pancreatitis, and polyarthritis (PPP) syndrome. Pancreatic panniculitis is a rare form of subcutaneous fat necrosis associated with underlying pancreatic disease. We describe a case of PPP syndrome and review the relevant literature associated with this rare clinical syndrome. Read More

Rev Esp Enferm Dig 2018 May;110(5):336

Pathology , Hospital de Braga, Portugal.

Pancreatic panniculitis is an uncommon and rare skin complication of systemic fat necrosis associated with pancreatitis post-ampullectomy. Besides the rarity of the condition, the clinical history and physical examination for diagnosis is also important. Read More

Rev Esp Enferm Dig 2018 May;110(5):329-331

Dermatología, Hospital Príncipe de Asturias, Alcalá de Henares.

Pancreatic panniculitis is a rare skin manifestation associated with pancreatic conditions. This condition has similar characteristics to those of other panniculitis types and its course parallels the triggering condition and may occasionally precede it. We report the case of a female patient with asymptomatic pancreatic panniculitis; the etiologic study identified a pancreatic acinar cell carcinoma with liver metastases. Read More

J Eur Acad Dermatol Venereol 2018 Mar 10. Epub 2018 Mar 10.

Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.

Background: Panniculitis occurring in dermatomyositis is uncommon, with only a few cases described in the literature, most of them as case reports.

Objective: This report describes the clinicopathological and immunohistochemical findings in a series of 18 patients with panniculitis associated with dermatomyositis.

Methods: In each patient, we collected the clinical data of the cutaneous lesions as well as the characteristic clinical and laboratory findings. Read More

Int J Mycobacteriol 2018 Jan-Mar;7(1):92-94

Department of Dermatology; Department of Pathology, Division of Dermatopathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

This report describes the presence of cutaneous nodules and ulceration of the right leg of 1-year duration in an elderly woman. Prior biopsies had demonstrated dermal and subcutaneous granulomatous inflammation. Special stains for microorganisms and cultures were repeatedly negative. Read More

Medicine (Baltimore) 2018 Jan;97(3):e9571

Laboratory of Pediatric Nephrology, Instiute of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Rationale: Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence of LEP in systemic lupus erythematosus (SLE) ranges from 2% to 5%. In the previous literature, most LEP patients were women aged from 20 to 60 years, while pediatric cases were rare, all of whom appeared on their own without SLE. Read More