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    Expression of cutaneous immunity markers during infant skin maturation.
    Pediatr Dermatol 2018 Apr 25. Epub 2018 Apr 25.
    Johnson & Johnson Santé Beauté France, Issy-les-Moulineaux, France.
    Background/objectives: Infant skin undergoes a maturation process during the early years of life. Little is known about the skin's innate immunity. We investigated the dynamics of innate immunity markers collected from the surface of infant skin during the first 36 months of life. Read More

    Mesenteric Panniculitis Presenting as Fever of Unknown Etiology in a Patient with History of Abdominal Surgery.
    Case Rep Gastrointest Med 2018 29;2018:5658039. Epub 2018 Jan 29.
    Rheumatology, Madigan Army Medical Center, Tacoma, WA, USA.
    Mesenteric panniculitis is characterized by nonspecific fibrous inflammation of the small bowel mesentery, appendix, and mesoappendix. Clinical course is usually benign and outcome is favorable. We report a case of mesenteric panniculitis presenting as fever of unknown etiology in a patient with history of abdominal surgery. Read More

    Exploring the combination of SSKI and topical heparin in a case of erythema nodosum migrans.
    Dermatol Ther 2018 Apr 11:e12610. Epub 2018 Apr 11.
    Department of Dermatology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.
    Erythema nodosum migrans (subacute nodular migratory panniculitis) is an uncommon type of panniculitis characterized by migrating subcutaneous nodules or plaque on the lower extremity. There are a very few cases of Erythema nodosum migrans reported and thus its appropriate treatment modality is not defined. We describe a case of a 30-year-old male with idiopathic erythema nodosum migrans which was manifest centrifugally spreading, slightly morpheaform erythematous plaque on the lower left leg. Read More

    Panniculitis associated with amyopathic dermatomyositis.
    An Bras Dermatol 2018 Jan-Feb;93(1):119-121
    Department of Pathology, Faculdade de Medicina de Jundiaí (FMJ) - Jundiaí (SP), Brasil.
    Panniculitis is a rare clinical finding in dermatomyositis, with less than 30 cases reported and there is only one case associated with the amyopathic subtype described in the literature. The present report describes a 49-year-old female patient that one year after being diagnosed with amyopathic dermatomyositis, presented indurated, painful, erythematous to violaceous nodules located on the upper limbs, thighs and gluteal region. Skin biopsy revealed lobular panniculitis with a lymphocytic infiltrate. Read More

    [Paraneoplastic syndromes in rheumatology].
    Z Rheumatol 2018 Apr 10. Epub 2018 Apr 10.
    Zentrum Innere Medizin, Medizinische Klinik und Poliklinik II, Rheumatologie/Klinische Immunologie, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
    Rheumatic paraneoplastic syndromes are paraneoplastic arthritis, palmar fasciitis and polyarthritis syndrome, remitting seronegative symmetrical synovitis with pitting edema, pancreatic panniculitis with polyarthritis, paraneoplastic vasculitis, cancer-associated myositis, hypertrophic osteoarthropathy (Marie-Bamberger disease) and tumor-induced osteomalacia. Typical clinical manifestations, pathogenesis, prognosis, and treatment of this entity are presented. Knowledge of these disease entities can lead to timely diagnosis of the underlying malignant disease and to a higher probability of a cure. Read More

    Cutaneous complication of perinatal hypoxia.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Dermatology Department, Hospital de Santarém EPE, Santarém, Portugal.
    Subcutaneous fat necrosis of the newborn is an uncommon, transient, and self-healing panniculitis, mostly affecting term newborns with perinatal complications. The authors present a case of a female full-term neonate, born from an uncomplicated pregnancy, admitted into the neonatology unit 5 hours after delivery because of refractory multifocal seizures in the context of hypoxic-ischemic encephalopathy. Nine days after birth, indurated and erythematous nodules and plaques were noted on the left arm and back. Read More

    The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.
    J Inflamm Res 2018 26;11:123-134. Epub 2018 Mar 26.
    Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
    Alpha-1 antitrypsin (AAT) is the most abundant serine protease inhibitor circulating in the blood. AAT deficiency (AATD) is an autosomal codominant condition affecting an estimated 3.4 million individuals worldwide. Read More

    Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis.
    Pediatrics 2018 Apr;141(Suppl 5):S496-S500
    Institut Imagine, INSERM U1163.
    We report on 4 children who presented with aseptic panniculitis associated with inherited immunodeficiency. Three patients had a B-cell immunodeficiency resulting from mutations in the and genes (no mutation was found in the third patient), and 1 had a T-cell deficiency (mutation in the gene). Panniculitis occurred before the age of 2 years in the 4 patients and preceded the onset of recurrent infections because of immunodeficiency in 2. Read More

    Fulminant hepatic failure in the setting of progressive ANCA-associated vasculitis associated with a rare alpha-1 antitrypsin phenotype, 'PiEE'.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
    Abnormalities in alpha-1 antitrypsin (AAT) proteins are risk factors for human disease. While the most common is AAT deficiency, a genetic disorder associated with chronic obstructive pulmonary disease, additional disorders associated with AAT abnormalities are increasingly recognised. We describe a middle-aged woman who presented with fulminant hepatic and multiorgan failure. Read More

    Panniculitis, pancreatitis, and polyarthritis: a rare clinical syndrome.
    Cutis 2018 Jan;101(1):E34-E37
    Midwest Center for Dermatology and Cosmetic Surgery, St. John Macomb-Oakland Hospital, Warren, Michigan, USA.
    A rare triad composed of lobular panniculitis in the setting of pancreatitis and polyarthritis is termed panniculitis, pancreatitis, and polyarthritis (PPP) syndrome. Pancreatic panniculitis is a rare form of subcutaneous fat necrosis associated with underlying pancreatic disease. We describe a case of PPP syndrome and review the relevant literature associated with this rare clinical syndrome. Read More

    Tender red subcutaneous nodules in an adult female: a challenging diagnosis.
    Rev Esp Enferm Dig 2018 Mar 12;110. Epub 2018 Mar 12.
    Pathology , Hospital de Braga, Portugal.
    Pancreatic panniculitis is an uncommon and rare skin complication of systemic fat necrosis associated with pancreatitis post-ampullectomy. Besides the rarity of the condition, the clinical history and physical examination for diagnosis is also important. Read More

    Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma.
    Rev Esp Enferm Dig 2018 Mar 12;110. Epub 2018 Mar 12.
    Dermatología, Hospital Príncipe de Asturias, Alcalá de Henares.
    Pancreatic panniculitis is a rare skin manifestation associated with pancreatic conditions. This condition has similar characteristics to those of other panniculitis types and its course parallels the triggering condition and may occasionally precede it. We report the case of a female patient with asymptomatic pancreatic panniculitis; the etiologic study identified a pancreatic acinar cell carcinoma with liver metastases. Read More

    Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases.
    J Eur Acad Dermatol Venereol 2018 Mar 10. Epub 2018 Mar 10.
    Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.
    Background: Panniculitis occurring in dermatomyositis is uncommon, with only a few cases described in the literature, most of them as case reports.

    Objective: This report describes the clinicopathological and immunohistochemical findings in a series of 18 patients with panniculitis associated with dermatomyositis.

    Methods: In each patient, we collected the clinical data of the cutaneous lesions as well as the characteristic clinical and laboratory findings. Read More

    Cutaneous infection with .
    Int J Mycobacteriol 2018 Jan-Mar;7(1):92-94
    Department of Dermatology; Department of Pathology, Division of Dermatopathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    This report describes the presence of cutaneous nodules and ulceration of the right leg of 1-year duration in an elderly woman. Prior biopsies had demonstrated dermal and subcutaneous granulomatous inflammation. Special stains for microorganisms and cultures were repeatedly negative. Read More

    Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report.
    Medicine (Baltimore) 2018 Jan;97(3):e9571
    Laboratory of Pediatric Nephrology, Instiute of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
    Rationale: Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence of LEP in systemic lupus erythematosus (SLE) ranges from 2% to 5%. In the previous literature, most LEP patients were women aged from 20 to 60 years, while pediatric cases were rare, all of whom appeared on their own without SLE. Read More

    Clues in Histopathological Diagnosis of Panniculitis.
    Am J Dermatopathol 2018 Mar;40(3):155-167
    Head of Surgical Pathology, Pathology Department, Hospital Univeristari General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.
    Background: Panniculitides comprise a group of heterogeneous inflammatory diseases. Nevertheless, histopathological study along with clinicopathological correlation usually led to a specific diagnosis. In most textbooks, the first step in the diagnosis is to classify them as mostly septal or lobular depending on where the inflammatory infiltrate is located. Read More

    Lesiones subcutáneas dolorosas en paciente con melanoma metastásico: un caso de paniculitis linfocítica asociado a vemurafenib.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Department of Dermatology, Dermatologist, Hospital Universitario Doctor Peset, Valencia, Spain.
    Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. Read More

    Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman.
    Indian Dermatol Online J 2018 Jan-Feb;9(1):47-49
    Department of Dermatology, Complejo Hospitalario de Navarra, Pamplona, Spain.
    Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype consisting of skin ulceration among other signs. Read More

    Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients.
    J Immunother Cancer 2018 Feb 12;6(1):14. Epub 2018 Feb 12.
    Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobullous disorders, lichenoid dermatitis, and vitiligo. Read More

    Histological and Immunological Description of the Leishmanin Skin Test in Ibizan Hounds.
    J Comp Pathol 2018 Jan 4;158:56-65. Epub 2018 Jan 4.
    Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain; Hospital MonVeterinari, Manacor, Mallorca, Spain. Electronic address:
    The leishmanin skin test (LST), a delayed-type hypersensitivity (DTH) reaction to Leishmania infantum, can specifically identify dogs that have made a cell-mediated immune response to L. infantum infection. The Ibizan hound appears to be more resistant to L. Read More

    Safety, tolerability, and efficacy evaluation of the SlimME device for circumference reduction.
    Lasers Surg Med 2018 Feb 7. Epub 2018 Feb 7.
    Queen Anne Street Medical Centre, 18-22 Queen Anne St, Marylebone W1G 8HU, London.
    Objective: To assess the short- and long-term thermal impact of subclinical and clinical regimens of a single, non-invasive uniform ultrasound treatment session on subcutaneous adipose tissue (SAT).

    Study Design: Prospective, open-label, single-arm, split-side study.

    Methods: Patients (n = 17) were subjected to uniform ultrasound treatment, delivered in a single session with the SlimME device. Read More

    [Dermatological features of auto-inflammatory recurrent fevers].
    Arch Pediatr 2018 Feb 1;25(2):150-162. Epub 2018 Feb 1.
    Université Paris-Saclay, university Paris-Sud, CHU de Bicêtre, 78, avenue du Général-Leclerc, Le-Kremlin-Bicêtre, France.
    Auto-inflammatory diseases are characterized by unexplained and recurrent attacks of systemic inflammation often involving the skin, joints, or serosal membranes. They are due to a dysfunction or dysregulation of the innate immunity, which is the first line of defense against pathogens. Early recognition of these diseases by the clinician, especially by pediatricians encountering such pathologies in pediatric patients, is primordial to avoid complications. Read More

    Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9237
    Division of Gastroenterology and Hepatology, Department of Internal Medicine.
    Rationale: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. Read More

    Acute myeloid leukemia presenting as erythema nodosum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8666
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Rationale: Erythema nodosum (EN), a type of septal panniculitis, could be a rare nonspecific cutaneous presentation of acute myeloid leukemia (AML).

    Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Read More

    Neutrophilic dermatoses: a broad spectrum of disease.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.
    Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -
    The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

    Cutaneous lupus erythematosus: clinico-pathologic correlation.
    G Ital Dermatol Venereol 2018 Apr 24;153(2):216-229. Epub 2018 Jan 24.
    Unit of Dermatology, "A. Perrino" Hospital, Brindisi, Italy.
    Cutaneous lupus erythematosus (CLE) is a chronic-relapsing disease. It is defined as a LE localized to the skin without any significant systemic symptoms. Its annual incidence is of 4 cases per 100,000 persons with a prevalence of 73 cases per 100,000 persons. Read More

    Acute kidney injury due to multiple Hymenoptera stings-a clinicopathological study.
    Clin Kidney J 2017 Aug 28;10(4):532-538. Epub 2017 Mar 28.
    Community Medicine, Indira Gandhi Medial College, Shimla, Himachal Pradesh, India.
    Background: Acute kidney injury (AKI) after multiple Hymenoptera stings is well known but still a rare phenomenon.

    Methods: We conducted a retrospective study of the clinicopathological spectrum of AKI due to multiple Hymenoptera stings over 13 years (July 2003-June 2016).

    Results: A total of 35 patients were diagnosed with AKI due to multiple Hymenoptera stings. Read More

    Mesenteric Panniculitis-First Case Series After Bariatric Surgery.
    Obes Surg 2018 Mar;28(3):881-885
    Bariatric and Metabolic Surgery, Wockhardt Hospitals, Mumbai, India.
    Mesenteric panniculitis is an uncommon pathology, of poorly understood etiology, characterized by progressive inflammation and fibrosis of the small bowel mesentery. This disease has been reported usually after other abdominal surgeries. We present two cases of young male patients who underwent laparoscopic sleeve gastrectomy and developed abdominal symptoms within 45-60 days of surgery. Read More

    Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients.
    BMC Gastroenterol 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, I.R.C.C.S. Fondazione Cà Granda, Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
    Background: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. Read More

    An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions.
    Am J Case Rep 2018 Jan 4;19:13-20. Epub 2018 Jan 4.
    Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.
    BACKGROUND Mesenteric panniculitis (MP) is an idiopathic chronic inflammatory condition of the mesentery. The main symptoms include abdominal pain, abdominal distention, weight loss, fever, nausea, and vomiting. The patients also present with chylous ascites in 14% of the cases and chylous pleural effusion (CPE) in very rare occasions. Read More

    Septolobular panniculitis in disseminated Lyme borreliosis.
    J Cutan Pathol 2018 Apr 9;45(4):274-277. Epub 2018 Feb 9.
    Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

    Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
    Biochem Biophys Res Commun 2018 01 28;495(4):2616-2621. Epub 2017 Dec 28.
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
    Sleep disturbances are associated with various metabolic diseases such as hypertension and diabetes. We had previously established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by disrupted circadian rhythms of wheel-running activity, core body temperature, and sleep-wake cycles. To evaluate the underlying mechanisms of metabolic disorders induced by CSD, we created mice with CSD for six weeks and fed them with a high-fat diet. Read More

    Panniculitis in the setting of dermato/rheumatologic diseases.
    G Ital Dermatol Venereol 2018 Apr 15;153(2):194-207. Epub 2017 Dec 15.
    Unit of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Panniculitides represent a heterogeneous group of inflammatory diseases that are traditionally considered one of the most difficult challenge for clinicians and pathologists. They may occur in a variety of dermato/rheumatologic diseases and are of particular relevance for clinicians dealing with such pathologies, including immune-mediated/autoimmune and autoinflammatory disorders. In fact, panniculitides can be the initial sign of presentation of a dermato/rheumatologic disease, thereby providing the physician with important clues to the correct diagnosis. Read More

    Successful treatment of erythema induratum with topical application of antituberculous drugs: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e9010
    Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Erythema induratum, a chronic recurrent lobular panniculitis with vasculitis, is strongly associated with Mycobacterium tuberculosis infection. The recommended drugs include isoniazid, rifampicin, and pyrazinamide, which are typically administered in combination (orally or intravenously). Till date, there are no reports about topical application of anti-tuberculous (anti-TB) drugs for treatment of erythema induratum. Read More

    Compression stockings as an effective treatment for erythema nodosum: Case series.
    Int J Womens Dermatol 2017 Dec 29;3(4):231-233. Epub 2017 Sep 29.
    Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ.
    Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. Read More

    Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features.
    J Am Acad Dermatol 2018 Apr 9;78(4):776-785. Epub 2017 Dec 9.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
    Melanoma differentiation-associated gene 5 (MDA5) is a recently described autoantigen target in a subset of patients with dermatomyositis. Anti-MDA5 dermatomyositis is characterized by a unique mucocutaneous and systemic phenotype that includes cutaneous and oral ulceration, painful palmar papules, alopecia, panniculitis, arthritis, a lower incidence of myositis, and, importantly, an elevated risk of interstitial lung disease with a potentially fatal course. Because the clinical features can differ substantially from those typically observed in cutaneous dermatomyositis, the diagnosis is often overlooked, which might negatively affect patient outcomes. Read More

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