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    Immunohistochemistry reveals an increased proportion of MYC-positive cells in subcutaneous panniculitis-like T-cell lymphoma compared with lupus panniculitis.
    J Cutan Pathol 2017 Aug 11. Epub 2017 Aug 11.
    Department of Pathology, Stanford University School of Medicine.
    Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a malignant primary cutaneous T-cell lymphoma that shares significant clinical, histopathologic, and immunophenotypic overlap with lupus erythematosus panniculitis (LEP).

    Methods: We performed immunohistochemistry for the MYC oncoprotein on 23 cases of SPTCL (one CD8 negative) and 12 cases of LEP to evaluate if there are quantitative or qualitative differences in protein expression of this marker in these entities.

    Results: In SPTCL cases, the percentage of all cells that were c-Myc positive ranged from 0. Read More

    Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T-Cell and NK/T-Cell Lymphomas: an International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation.
    Biol Blood Marrow Transplant 2017 Aug 7. Epub 2017 Aug 7.
    Vanderbilt University Medical Center, Nashville, TN, USA.
    Recognizing the significant biologic and clinical heterogeneity of mature T-cell and NK/T-cell lymphomas, the American Society for Blood and Marrow Transplantation invited experts to develop clinical practice recommendations related to the role of auto-HCT and allo-HCT for specific histologic subtypes. We used the GRADE methodology to assist in moving from evidence to decision-making and ultimately generating final recommendations. Auto-HCT in front-line consolidation is recommended in PTCL-NOS, AITL, ALCL-ALK negative, NK/T-cell (disseminated), EATL and hepatosplenic lymphomas. Read More

    Mucocutaneous Manifestations in Patients with Rheumatoid Arthritis: A Cross-sectional Study from Eastern India.
    Indian J Dermatol 2017 Jul-Aug;62(4):411-417
    Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, West Bengal, India.
    Background: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease.

    Aims: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India.

    Methodology: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Read More

    Erythema Ab Igne Caused By Laptop Computer.
    Open Access Maced J Med Sci 2017 Jul 22;5(4):490-492. Epub 2017 Jul 22.
    Universita degli Studi di Messina, Policlinico Universitario, Via Consolare Valeria, Messina, Sicilia 98125, Italy.
    Erythema ab igne (EAI) represents the stereotype of a modern technology induced disease. Originally produced by repeated exposure of the skin to a heat source, more often because of habits related to the job or personal activities, this condition now tends to occur more frequently, being associated with a variety of modern instruments. The aim of our report is to discuss this strange medical condition with a focus on clinical features, possible confounding differential diagnoses and recommendations for prevention. Read More

    Well-differentiated inflammatory liposarcoma with metastasis in a 6-y-old cat.
    J Vet Diagn Invest 2017 Aug 1:1040638717725349. Epub 2017 Aug 1.
    Departments of Veterinary Clinical Sciences (Alvarez, Shaffer) School of Veterinary Medicine, University of Wisconsin, Madison, WI.
    Liposarcomas are rare malignant tumors showing adipocytic differentiation. We report a well-differentiated liposarcoma in a 6-y-old, male neutered cat with a prominent inflammatory component and metastatic spread to the lungs. The patient was initially presented because of fever, lethargy, and a firm subcutaneous inguinal mass. Read More

    An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis.
    Case Rep Hematol 2017 3;2017:5498034. Epub 2017 Jul 3.
    Albert Einstein Medical Center, Philadelphia, PA, USA.
    Microangiopathic hemolytic anemia (MAHA) requires an aggressive approach since primary thrombotic microangiopathy syndromes such as thrombotic thrombocytopenic purpura (TTP) can progress rapidly to a fatal outcome. Differential diagnosis can be challenging even for an experienced hematologist. We present a case of a 52-year-old male who presented with symptoms of mesenteric panniculitis and showed signs of MAHA. Read More

    J Zoo Wildl Med 2017 Jun;48(2):544-548
    A 19-yr-old castrated male binturong ( Arctictis binturong ) with a history of recurrent pyogranulomatous panniculitis, lymphangitis, and dermatitis was presented for evaluation of hyporexia and tenesmus. A large caudal abdominal mass was palpated on physical examination. On ultrasound, the mass encircled and obstructed the left ureter, resulting in hydroureter and hydronephrosis. Read More

    [Paniculitis as manifestation of prolonged febrile syndrome: Case report].
    Rev Chil Pediatr 2017 Jun;88(3):398-403
    Departamento Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Fever of unknown origin (FUO) is defined as fever over 7 to 10 days without a diagnosis despite a complete initial study. The most frequent causes are infections, autoimmune and tumors. Even though most cases are self-limited there is a minority that has an underlying etiology with an ominous forecast, encouraging a systematized study. Read More

    Duplex Doppler Sonographic Assessment of the Superior Mesenteric Artery in Patients With Mesenteric Panniculitis.
    J Ultrasound Med 2017 Jul 21. Epub 2017 Jul 21.
    Department of Radiology, Mersin University Faculty of Medicine, Mersin, Turkey.
    Objectives: We aimed to determine how the hemodynamic parameters of the superior mesenteric artery are affected in mesenteric panniculitis.

    Methods: Twenty-one patients with a diagnosis of mesenteric panniculitis on computed tomography were evaluated with duplex Doppler sonography. The control group consisted 20 asymptomatic volunteers. Read More

    A case of severe erythema nodosum induced by methimazole.
    Saudi Pharm J 2017 Jul 12;25(5):813-815. Epub 2016 Nov 12.
    Yildirim Beyazit University, Ataturk Training and Research Hospital, Dermatology Clinic, Ankara, Turkey.
    Erythema nodosum (EN), is the most common variant of septal panniculitis and is possibly a delayed hypersensitivity reaction triggered by a wide range of antigenic stimuli. Hypersensitivity reactions due to medications have been recognized as a cause of 3-10% of EN cases. Case reports of EN associated with the anti-thyroid drugs are quite rarely reported in the literature even if there is a common use of anti-thyroid drugs. Read More

    Is there an association between mesenteric panniculitis and lymphoma? A case control analysis.
    Clin Radiol 2017 Jul 13. Epub 2017 Jul 13.
    Department of Diagnostic Imaging, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Aim: To determine the prevalence and association of mesenteric panniculitis (MP) in a group of patients with non-Hodgkin's lymphoma (NHL) compared to control group.

    Materials And Methods: We retrospectively evaluated computed tomography (CT) and combined positron-emission tomography (PET) with CT examinations of a total of 166 patients who were diagnosed with NHL over a period of 5 years (2008-2013). The control group consisted of 332 subjects who were matched for gender and age at the time period the examinations were performed on the study group. Read More

    Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Jul 16. Epub 2017 Jul 16.
    Section of Dermatology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations. Read More

    Wolf's Panniculitis.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):397-398. Epub 2017 Jun 11.
    Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
    A 28-year-old male patient, presented with a one-week history of pain and itching on the skin of the left upper leg. Erythematous indurated, warm and painful on palpation, subcutaneous plaques and nodules were clinically observed, affecting the skin of the left upper leg, within a recent black-wolf tattoo. The diagnosis of traumatic panniculitis with superposed bacterial infection, provoked by a wolf tattoo was made. Read More

    Bilateral ptosis as first presentation of cytophagic histiocytic panniculitis: a case report.
    BMC Ophthalmol 2017 Jul 1;17(1):112. Epub 2017 Jul 1.
    Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, China.
    Background: Cytophagic histiocytic panniculitis (CHP) is a rare form of nodular panniculitis that may progress to panniculitis-like T-cell lymphoma. We report a case of CHP that first manifested as bilateral ptosis, which is the first reported case of this presentation.

    Case Presentation: A 25-year-old woman without medical history was referred to the neurology department of our hospital for evaluation of bilateral ptosis. Read More

    The Histopathological Spectrum of Pseudolymphomatous Infiltrates in Cutaneous Lupus Erythematosus.
    Am J Dermatopathol 2017 Jun 20. Epub 2017 Jun 20.
    *Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria; †Anatomic Pathology Unit, Hospital Universitário Polydoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis, Brazil; ‡Anatomic Pathology Unit, Macerata General Hospital, Macerata, Italy; §Anatomic Pathology Unit, Department of Surgical Science and Integrated Diagnostics, University of Genoa, IRCCS AOU San Martino IST, Genoa, Italy; ¶Dermatopathology Unit, San Gallicano Dermatology Institute, Rome, Italy; ‖Department of Dermatology, Galliera Hospital, Genoa, Italy; **School of Pathology, University of Milan, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; and ††Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
    The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Read More

    Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide.
    Int J Chron Obstruct Pulmon Dis 2017 8;12:1683-1694. Epub 2017 Jun 8.
    Pneumology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
    The alpha-1 antitrypsin (AAT) haplotype Pi*S, when inherited along with the Pi*Z haplotype to form a Pi*SZ genotype, can be associated with pulmonary emphysema in regular smokers, and less frequently with liver disease, panniculitis, and systemic vasculitis in a small percentage of people, but this connection is less well established. Since the detection of cases can allow the application of preventive measures in patients and relatives with this congenital disorder, the objective of this study was to update the prevalence of the SZ genotype to achieve accurate estimates of the number of Pi*SZ subjects worldwide, based on studies performed according to the following criteria: 1) samples representative of the general population, 2) AAT phenotyping characterized by adequate methods, and 3) selection of studies with reliable results assessed with a coefficient of variation calculated from the sample size and 95% confidence intervals. Studies fulfilling these criteria were used to develop tables and maps with an inverse distance-weighted (IDW) interpolation method, to provide numerical and geographical information of the Pi*SZ distribution worldwide. Read More

    A case of malignant peritoneal mesothelioma suggesting the utility of combining double-contrast radiography and endoscopy with computed tomography for diagnosis.
    Clin J Gastroenterol 2017 Aug 23;10(4):371-376. Epub 2017 Jun 23.
    Department of Gastroenterology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Minami-ku, Kumamoto, Kumamoto, 862-0965, Japan.
    A 68-year-old woman presented with abdominal pain, weight loss, and vomiting. Enhanced computed tomography (CT) showed slightly increased density in the mesentery and edema of the third portion of the duodenum and proximal jejunum. Little ascites, but no primary lesion, lymph node metastases, or distant metastases, were observed. Read More

    High-frequency ultrasound features in a case of gouty panniculitis.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, Hospital Universitario Infanta Sofía, Madrid, Spain.
    Gouty panniculitis is caused by the deposition of urate crystals in the subcutaneous tissue, accompanied by a lobular panniculitis. It presents as subcutaneous nodules, most commonly located on the lower extremities. Being an unusual clinical presentation of gout, the sonographic findings of gouty panniculitis have been scarcely described in the literature. Read More

    Lupus mastitis as a first manifestation of systemic disease: About two cases with a review of the literature.
    Eur J Radiol 2017 Jul 6;92:124-131. Epub 2017 May 6.
    Centre de recherche et d'investigation des maladies du sein (CRID), Department of Radiology, Hôtel-Dieu de Montréal, Centre Hospitalier Universitaire de Montréal (CHUM), Canada.
    Lupus mastitis is an uncommon manifestation of systemic lupus erythematosus (SLE) that affects the subcutaneous fat in the breast, much like lupus panniculitis, but additionally involves the mammary gland. We report on two women for whom lupus mastitis was the initial manifestation of SLE and provide a literature review of 34 additional cases reported in the Anglo-Saxon and French literature since 1971, making this the largest review to date. Lupus mastitis (LM) can manifest clinically as subcutaneous masses that may be painful, or may present cutaneous involvement such as thickening and discolouration. Read More

    Panniculitis Associated with MEK Inhibitor Therapy: An Uncommon Adverse Effect.
    Case Rep Dermatol 2017 Jan-Apr;9(1):80-85. Epub 2017 Mar 21.
    aDepartment of Dermatology, Université Paul Sabatier-Toulouse III et Institut Universitaire du Cancer de Toulouse, Toulouse, France.
    The combination of MEK inhibitor (cobimetinib, trametinib) and BRAF inhibitor (vemurafenib, dabrafenib) is now the first-line treatment in patients with BRAF V600-mutated metastatic melanoma. This association reduces cutaneous adverse events induced by BRAF inhibitors alone, including photosensitivity, hand-foot syndrome, hyperkeratosis, alopecia, skin papillomas, keratoacanthomas, and squamous-cell carcinomas. While panniculitis has exceptionally been reported with BRAF inhibitors, this rare side effect has never been described with the use of MEK inhibitors. Read More

    Sclerosing mesenteritis and mesenteric panniculitis - clinical experience and radiological features.
    BMC Gastroenterol 2017 Jun 13;17(1):75. Epub 2017 Jun 13.
    Department of Medicine, Division of Gastroenterology, Hospital of Trelleborg, Trelleborg, Sweden.
    Background: Sclerosing mesenteritis (SM) is sometimes used as an umbrella-term for idiopathic inflammatory conditions in the mesentery. Mesenteric panniculitis (MP) is a radiological finding and its relation to clinical SM is not fully understood. The aims of this study were to determine whether any correlation could be found between the radiological findings and the clinical disease course. Read More

    Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report.
    Mol Clin Oncol 2017 Jun 5;6(6):866-870. Epub 2017 May 5.
    Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
    Pancreatic acinar cell carcinoma (PACC) is a rare tumor of the exocrine pancreas, representing only 1% of all pancreatic malignancies. A 50-year-old man presented with edema of the thumb joints bilaterally, followed by an appearance of masses in the bilateral lower extremities and fever (38°C). The masses were diagnosed as panniculitis by skin biopsy, and multiple intraperitoneal masses were incidentally detected on pelvic magnetic resonance imaging performed to investigate the leg abnormalities. Read More

    Lysinibacillus massiliensis Panniculitis Masquerading as Erythema Nodosum: A Case Report.
    Open Forum Infect Dis 2017 6;4(2):ofx072. Epub 2017 Apr 6.
    Infectious Diseases.
    Lysinibacillus massiliensis, formerly Bacillus massiliensis, is an environmental Gram-positive bacillus that is generally non-pathogenic. Rare case reports in immunosuppressed patients have described sepsis with this organism. In this study, we report a case of L massiliensis as a cause of infectious panniculitis mimicking erythema nodosum after infusion of autologous adipose-derived stem cells in an immunosuppressed patient with refractory Crohn's disease. Read More

    Lupus profundus limited to a site of trauma: Case report and review of the literature.
    Int J Womens Dermatol 2017 Jun 5;3(2):117-120. Epub 2017 May 5.
    St. George Hospital, Sydney, Australia.
    Lupus erythematosus profundus (LEP) is a rare form of chronic cutaneous lupus erythematosus. We report on a case of a 56-year-old Caucasian woman who presented with a single, persistent, painful rash on the left hip and lateral aspect of the left upper thigh, which had been present for 2.5 years. Read More

    Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.
    Clin Rev Allergy Immunol 2017 May 26. Epub 2017 May 26.
    Université Pierre et Marie Curie-Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Dermatologie-Allergologie, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
    Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. Read More

    Bumps in the Road: Panniculitis in Children and Adolescents Treated with Vemurafenib.
    Pediatr Dermatol 2017 May;34(3):337-341
    Division of Dermatology, Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois.
    Vemurafenib is increasingly being used to treat nonmelanoma tumors that are positive for the BRAF V600E mutation. We report three children who presented with panniculitis induced by vemurafenib while undergoing treatment for central nervous system tumors and review the literature. Read More

    [Pathergic postsurgical-induced Pyoderma gangrenosum].
    Rev Med Liege 2017 May;72(5):227-232
    Service de Chirurgie Plastique, Esthétique et Reconstructrice, Clinique Saint-Vincent de Rocourt (CHC), Liège, Belgique.
    Pyoderma gangrenosum (PG) is a rare pustular and ulcerative inflammatory disease belonging to the group of neutrophilic dermatoses. It is frequently associated with systemic immune diseases. In this context the PG can be exceptionally triggered by tissue trauma such as surgery (pathergy). Read More

    Alpha-1-antitrypsin deficiency-related panniculitis: two cases with diverse clinical courses.
    Clin Exp Dermatol 2017 Jul 17;42(5):520-522. Epub 2017 May 17.
    Department of Dermatology, Galway University Hospital, Galway, Ireland.
    Alpha-1-antitrypsin deficiency (AATD)-related panniculitis is an extremely rare and underdiagnosed entity, and there is a paucity of data on its treatment. We report two cases of AATD-related panniculitis. The first was a 24-year-old woman with known AATD who presented with painful leg ulcers refractory to treatment with corticosteroids and colchicine. Read More

    Coinfection by Streptococcus phocae and cetacean morbillivirus in a short-beaked common dolphin Delphinus delphis.
    Dis Aquat Organ 2017 05;124(3):247-252
    Veterinary Histology and Pathology, Institute of Animal Health, Veterinary College, University of Las Palmas de Gran Canaria, Trasmontana s/n, Arucas 35413, Las Palmas de Gran Canaria, Spain.
    We describe gross, histopathological, and immunohistochemical features of Streptococcus phocae and cetacean morbillivirus coinfection in a short-beaked common dolphin Delphinus delphis. Major gross findings were cutaneous purulent nodules in the tail fluke, vegetative mitral valve endocarditis, and presumed postpartum pyometra. Histologic examination revealed bacterial septicemia characterized by widespread intravascular coccoid bacterial emboli. Read More

    Mycobacterial panniculitis caused by Mycobacterium thermoresistibile in a cat.
    JFMS Open Rep 2016 Jul-Dec;2(2):2055116916672786. Epub 2016 Oct 11.
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
    Case Summary: A domestic shorthair cat was evaluated for chronic, bilateral, ulcerative dermatitis affecting the inguinal region and lateral aspects of both pelvic limbs. Histopathologic examination of skin biopsies collected throughout the course of disease revealed chronic pyogranulomatous ulcerative dermatitis. Aerobic bacterial skin cultures yielded growth of a methicillin-resistant Staphylococcus aureus and Corynebacterium amycolatum. Read More

    Cutaneous Lymphomas with Cytotoxic Phenotype.
    Surg Pathol Clin 2017 Jun 28;10(2):409-427. Epub 2017 Mar 28.
    Dermatopathology Laboratory, St John's Institute of Dermatology, St Thomas' Hospital, South Wing, Staircase C, Westminster Bridge Road, London SE1 7EH, UK. Electronic address:
    Primary cutaneous cytotoxic lymphomas are T-cell or natural killer-cell lymphomas that express 1 or more cytotoxic markers. These neoplasms constitute a spectrum of diseases. In this review, an overview of clinical, morphologic, and phenotypical features of each subtype is provided. Read More

    Sonography of Dermatologic Emergencies.
    J Ultrasound Med 2017 May 4. Epub 2017 May 4.
    Departments of Imaging and Dermatology, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Faculty of Medicine, University of Chile, Santiago, Chile.
    Dermatologic conditions may be the subjects of potential emergency consultations, and the knowledge of their sonographic appearance can facilitate an early diagnosis and management. In this pictorial essay, the sonographic dermatologic anatomy, technique, and conditions that can be supported by a prompt sonographic diagnosis are reviewed. The sonographic signs that may help diagnose these entities are discussed with a practical approach. Read More

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