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Skeletal Radiol 2022 May 23. Epub 2022 May 23.

Department of Radiology, University of Washington, 4245 Roosevelt Way NE, Box 354755, Seattle, WA, 98105, USA.

Rheumatic paraneoplastic syndromes are rare syndromes that occur at distant sites from the underlying tumor and may involve the bones, joints, fasciae, muscles, or vessels. In the absence of a known tumor, early recognition of a rheumatic syndrome as paraneoplastic permits dedicated work-up for, and potentially early treatment of an occult malignancy. Although there is a continuously growing list of paraneoplastic rheumatic disorders, not all of these disorders have a well-established association with a neoplastic process. Read More

Front Pediatr 2022 28;10:845424. Epub 2022 Apr 28.

Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas after fetal or perinatal distress. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. Treatments have included hydration, furosemide and corticosteroids. Read More

Lupus 2022 May 13:9612033221099873. Epub 2022 May 13.

Division of Rheumatology, Department of Internal Medicine, 284697Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.

Lupus profundus, often known as lupus panniculitis, is a rare form of persistent cutaneous lupus erythematosus. It usually manifests as painful plaques or nodules that can ulcerate and cause atrophy and scarring. It may respond to topical treatments and antimalarials, although treatment might be difficult at times, necessitating immunosuppressive medications. Read More

Front Pediatr 2022 25;10:837568. Epub 2022 Apr 25.

Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom.

Aicardi-Goutières syndrome (AGS) is a rare hereditary early-onset encephalopathy. The syndrome was first described in 1984, and is characterised by upregulation of the type I interferon (IFN) pathway, which is involved in the host immune response against viral infections, including SARS-CoV-2. Whilst defects in type I IFN pathways have been described in association with severe coronavirus disease 2019 (COVID-19), less is known about the outcomes of upregulation. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):139-142

Department of Ultrasound, Second Medical Center; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.

Pancreatic panniculitis (PP) is a necrotizing inflammation of subcutaneous fat that is a rare complication of pancreatic disease appearing in 2% to 3% of all patients. It is more common in the elderly and often affects the extremities. It presents as skin inflammation with pain and erythema nodules. Read More

Medicine (Baltimore) 2022 Apr 29;101(17):e29143. Epub 2022 Apr 29.

Department of Gastroenterology and Hepatology, Changi General Hospital, SingHealth, Singapore.

Background: Mesenteric panniculitis (MP) is a non-specific, localized inflammation at the mesentery of small intestines which often gets detected on computed tomography. An association with malignant neoplasms remains unclear. We performed a systematic review and meta-analysis to examine the association of malignancy with MP. Read More

Asia Pac J Clin Oncol 2022 May 4. Epub 2022 May 4.

Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan (ROC).

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell lymphoma, which is indolent in nature but could claim life if not correctly diagnosed and promptly treated. SPTCL is usually presented clinically as painless subcutaneous and erythematous nodules over the trunk or extremities. Active clinical vigilance for these subcutaneous nodules or panniculitis-like lesions is warranted. Read More

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Departamento de Docencia e Investigacion, Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador Servicio de Patologia, Hospital Metropolitano, Quito, Ecuador.

Primary cutaneous diffuse large B-cell lymphoma, leg type is a rare entity accounting for 4% of all primary cutaneous lymphomas whose clinical presentation encompasses a range of possibilities. COVID-19 has caused a delay in diagnosis of malignant neoplasms and consequently, this has resulted in poorer prognoses. A 62-year-old woman presented with two smooth-surfaced, mobile, well-circumscribed, oval, skin-colored nodules approximately one-cm in diameter with nonerythematous borders on the lower third of the left leg. Read More

Am J Dermatopathol 2022 Apr 11. Epub 2022 Apr 11.

Department of Pathology, CHU Henri Mondor, Creteil, France.

Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare but well-defined entity, often associated with autoimmune manifestations, generally with a good prognosis unless associated with hemophagocytic syndrome. Typically, the lymphoma cells rim the adipocytes and are characterized by a CD8+ cytotoxic phenotype. We report 2 cases of SPTCL where the first biopsies only showed subcutaneous fat necrosis without any lymphoma cell visible. Read More

Cureus 2022 Apr 7;14(4):x30. Epub 2022 Apr 7.

College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

Cureus 2022 Apr 7;14(4):x50. Epub 2022 Apr 7.

College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

Children (Basel) 2022 Apr 4;9(4). Epub 2022 Apr 4.

Pediatric Unit, Department of NEUROFARBA, Meyer Children's University Hospital University of Florence, Viale Pieraccini 24, 50137 Florence, Italy.

Erythema nodosum (EN) is the most frequent form of panniculitis in children. We performed a literature review analyzing studies on pediatric EN published from 1990 to February 2022. EN is rare in pediatric age. Read More

Hum Pathol 2022 Apr 19;125:48-58. Epub 2022 Apr 19.

The University of Chicago Medicine, Departments of Pathology, Section of Hematopathology, USA. Electronic address:

Normal T cells express high levels of B-cell lymphoma-2 (BCL2) protein, and data regarding BCL2 expression status and its diagnostic utility in T-cell lymphoma are scarce. We evaluated BCL2 expression in a series of mature T-cell lymphoproliferations (TCLs) including indolent and more recently recognized entities (follicular helper T-cell [TFH] lymphomas). Sixty-six neoplastic biopsies (60 patients) representing mature nodal, extranodal, and leukemia T-cell neoplasms were collected from three institutes (2 US and 1 Japan) and were compared with reactive T cells in 8 benign tissues/blood and 9 T cell-rich B-cell proliferations. Read More

Indian J Dermatol Venereol Leprol 2022 May-Jun;88(3):381-384

Departments of General Medicine, Government Medical College, Thrissur, Kerala, India.

Br J Clin Pharmacol 2022 Apr 17. Epub 2022 Apr 17.

Department of Clinical Pharmacology, University Hospital of Monastir. University of Monastir, Tunisia.

Erythema nodosum (EN), the most common form of panniculitis, is a reactive inflammation of the subcutaneous fat clinically presented with a sudden onset of painful, erythematous, nodular, subcutaneous lesions, typically localized to the pretibial area. EN is commonly caused by numerous infections (especially beta-haemolytic streptococcal infections), autoimmune diseases (sarcoidosis), inflammatory bowel conditions and drugs. EN induced by Covid-19 vaccines is rarely reported. Read More

J Dermatol 2022 Apr 17. Epub 2022 Apr 17.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Behçet's disease (BD) has a heterogeneous spectrum of disease manifestations featuring the involvement of different organs and can be characterized with different symptoms depending on the clinical department in charge. We retrospectively reviewed BD patients seen at our hospital and investigated the presence of neutrophils producing neutrophil extracellular traps (NET) in those patients. Immunolabeling of myeloperoxidase and histone citrullination proteins was performed on skin biopsies from three BD patients who had skin biopsy-proven superficial vein thrombophlebitis in their erythema nodosum-like lesions. Read More

Med Arch 2022 Feb;76(1):72-74

Department of Dermatology, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.

Background: Erythema nodosum (EN) is a common form of panniculitis that could be triggered by numerous conditions including infectious and non-infectious conditions. So far, few cases of EN caused by COVID-19 vaccine had been reported.

Case Report: We report a case of atypical presentation of EN mimicking cellulitis in a patient who received the first dose of the Pfizer-BioNTech COVID-19 vaccine. Read More

Ocul Immunol Inflamm 2022 Apr 11:1-4. Epub 2022 Apr 11.

Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Purpose: Even though subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus panniculitis (LEP) are two separate entities, recently they were claimed to represent two ends of a spectrum of T-cell-mediated orbital lymphoproliferative diseases.

Methods: A 78-year-old woman presented with a 1-month history of right-sided periorbital swelling and redness. There was a palpable mass in the medial right lower eyelid with restriction of upward and lateral gaze. Read More

J Cancer Res Ther 2021 Dec;17(7):1751-1754

Department of Hepatobiliary Surgery, First Affiliated Hospital of Shandong First Medical University, Shandong Province, Jinan, China.

Extrapancreatic manifestations can complicate pancreatic disorders. Pancreatic panniculitis, characterized by subcutaneous fat necrosis, develops in 0.3%-3% of patients with pancreatic disorders. Read More

SAGE Open Med Case Rep 2022 25;10:2050313X221086317. Epub 2022 Mar 25.

Section of Pediatric Rheumatology, Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.

Juvenile dermatomyositis is a rare autoimmune myopathy of childhood, associated with systemic vasculopathy, primarily affecting the capillaries. Panniculitis is seen histologically in about 10% of patients with dermatomyositis; however, its clinical presentation is rare, with only 30 cases presented in the literature to date. The histopathology overlaps with other inflammatory disease states, and is almost identical to the panniculitis seen in lupus erythematous panniculitis. Read More

Br J Dermatol 2022 Mar 23. Epub 2022 Mar 23.

Department of Dermatology Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

Eur J Clin Microbiol Infect Dis 2022 May 18;41(5):849-852. Epub 2022 Mar 18.

Clinical Immunology Department, Hôpital Saint Louis, Paris, France.

Ibrutinib is a Bruton tyrosine kinase (BTK) inhibitor used in B-cell lymphoproliferative disorders. Patients with genetic BTK deficiency are susceptible to recurrent and severe Campylobacter infections. We report 4 patients treated with ibrutinib who developed chronic or extra-digestive campylobacteriosis resembling ibrutinib-related adverse events including diarrhea (n = 4), panniculitis (n = 2), and arthritis (n = 1). Read More

Front Oncol 2022 1;12:779230. Epub 2022 Mar 1.

Hematopathology Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Center, Homi Bhabha National Institute (HBNI) University, Mumbai, India.

Background: T-cell/NK-cell non-Hodgkin's lymphoma (T/NK-NHL) is an uncommon heterogeneous group of diseases. The current classification of T/NK-NHL is mainly based on histopathology and immunohistochemistry. In practice, however, the lack of unique histopathological patterns, overlapping cytomorphology, immunophenotypic complexity, inadequate panels, and diverse clinical presentations pose a great challenge. Read More

An Bras Dermatol 2022 May-Jun;97(3):326-331. Epub 2022 Mar 7.

Department of Dermatology, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Pseudomonas aeruginosa is a Gram-negative bacillus that frequently causes septicemia, abscesses and infections in skin wounds. Panniculitis caused by this microorganism is unusual and there are few well-documented cases, none of them in a patient with systemic lupus erythematosus. The present report describes an immunosuppressed patient with systemic lupus erythematosus who developed panniculitis caused by Pseudomonas aeruginosa, with a review of the literature on this rare presentation. Read More

JAAD Case Rep 2022 Mar 31;21:154-156. Epub 2022 Jan 31.

Department of General Surgery, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India.

Ann Dermatol 2022 Feb 27;34(1):83-85. Epub 2022 Jan 27.

Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea.

Clin Case Rep 2022 Feb 13;10(2):e05462. Epub 2022 Feb 13.

Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

Subcutaneous panniculitis-like T-cell lymphoma is a rare and highly malignant extra-nodal lymphoma. It has a wide range of clinical presentations (such as periorbital swelling as in our case) and should be considered in the differential diagnosis of systemic lupus erythematosus, especially in children. Read More

Clin Exp Dermatol 2022 Feb 20. Epub 2022 Feb 20.

Department of Dermatology, University of Heidelberg, Heidelberg, Germany.

Subcutaneous panniculitis-like T-cell lymphoma is a rare, indolent cutaneous cytotoxic alpha-beta T-cell lymphoma, where no specific therapy regimen is defined. We present a case with a diagnostically challenging association with anti-double stranded DNA and provides one of the first reports of a successful treatment with mycophenolate mofetil and glucocorticosteroids. Read More

Cureus 2022 Jan 17;14(1):e21314. Epub 2022 Jan 17.

College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

Coronavirus disease 2019 (COVID-19) typically involves the respiratory system, but gastrointestinal involvement is common. Further, patients with severe COVID-19 are at high risk to develop gastrointestinal complications, including bowel ischemia, ileus, and deranged liver enzymes. We present the case of a 44-year-old woman with mild COVID-19 pneumonia who was in home isolation. Read More

Exp Hematol Oncol 2022 Feb 16;11(1). Epub 2022 Feb 16.

Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Angers, France.

VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is an inflammatory disorder with hematological and systemic features. A recent study demonstrated that the dermal infiltrate in neutrophilic dermatosis from VEXAS patients is derived from the pathological UBA1-mutated myeloid clone. Neutrophilic dermatosis is, however, only one of the various skin involvements observed in VEXAS syndrome. Read More