7,306 results match your criteria Cold Agglutinin Disease


Coombs-positive refractory acquired thrombotic thrombocytopenic purpura in a patient with chronic myelomonocytic leukemia successfully treated with rituximab.

Acta Clin Belg 2019 Apr 22:1-5. Epub 2019 Apr 22.

b Intensive Care Unit, Department of Internal Medicine , University Hospital Centre Zagreb , Zagreb , Croatia.

Objectives: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare autoimmune disorder characterized by auto-antibodies to Willebrand factor (vWF) cleaving enzyme (ADAMTS13), resulting in unusually large vWF multimers that lead to platelet aggregation, microthrombi formation and microangiopathic hemolytic anemia. Hemolysis in aTTP is mechanical; thus, direct antiglobulin test (Coombs test) is usually negative. Multiple autoimmune conditions and various auto-antibodies have been described in the context of chronic myelomonocytic leukemia (CMML). Read More

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http://dx.doi.org/10.1080/17843286.2019.1608395DOI Listing

Utilisation of Flow-cytometry in the Diagnosis of Auto Immune Haemolytic Anaemia.

Indian J Hematol Blood Transfus 2019 Apr 5;35(2):297-303. Epub 2018 Oct 5.

3Cleveland Clinic, Cleveland, OH 44195 USA.

Auto Immune Haemolytic Anaemia (AIHA) is one of the most common types of acquired haemolytic anaemias. Its main cause is auto-antibody mediated rapid destruction of Red Blood Cells (RBCs). Demonstration of a positive Direct Antiglobulin Test also known as Coomb's test, against these autoantibodies is the crucial serological assay in the diagnosis of AIHA. Read More

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http://dx.doi.org/10.1007/s12288-018-1017-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439060PMC
April 2019
1 Read

Clinical spectrum, evolution and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.

Eur J Haematol 2019 Apr 15. Epub 2019 Apr 15.

Service de médecine interne, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est, Créteil, France.

Objective: Angioimmunoblastic T-cell lymphoma (AITL) are frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.

Method: AITL patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio). Read More

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http://dx.doi.org/10.1111/ejh.13239DOI Listing
April 2019
2 Reads

Diagnosis and treatment of cold agglutinin disease.

Clin Adv Hematol Oncol 2019 Mar;17(3):162-165

MedStar Georgetown University Hospital, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.

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March 2019
1 Read

Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy.

Saudi Med J 2019 Apr;40(4):397-400

Reproductive and In Vitro Fertilization Unit, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. E-mail.

Ovarian teratoma is a rare cause of autoimmune hemolytic anemia (AIHA) by warm antibodies, resistant to corticosteroid therapy. This also implies that ovarian teratoma should be included in the differential diagnosis of AIHA, whether or not associated with pregnancy. We present a case of a primigravida who presented with ovarian dermoid cysts and AIHA at 24 weeks of gestation. Read More

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http://dx.doi.org/10.15537/smj.2019.4.24107DOI Listing
April 2019
3 Reads

Development of Multiple Myeloma of the IgA Type in a Patient with Cold Agglutinin Disease: Transformation or Coincidence?

Case Rep Hematol 2019 4;2019:1610632. Epub 2019 Mar 4.

Department of Research and Innovation, Haugesund Hospital, Haugesund, Norway.

Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia and a distinct, clonal bone marrow lymphoproliferative disorder, characterized in most cases by a monoclonal IgMκ serum protein. We describe a CAD patient presenting with a monoclonal immunoglobulin of the IgA class. For years, she remained asymptomatic apart from the hemolytic anemia until eventually she developed multiple myeloma (MM) of the IgA phenotype. Read More

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http://dx.doi.org/10.1155/2019/1610632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425334PMC
March 2019
1 Read

Hot and Cold: A Concurrent Warm and Cold Autoimmune Hemolytic Anemia in B-cell Prolymphocytic Leukemia.

Acta Haematol 2019 Apr 4;141(4):222-224. Epub 2019 Apr 4.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1159/000495779DOI Listing
April 2019
2 Reads

Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes.

Blood 2019 Apr 2. Epub 2019 Apr 2.

Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163-Institut Imagine, Paris, France.

Evans syndrome (ES) is a rare severe autoimmune disorder characterized by the combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most cases, the underlying cause is unknown. We sought to identify genetic defects in pediatric ES (pES), based on a hypothesis of strong genetic determinism. Read More

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http://dx.doi.org/10.1182/blood-2018-11-887141DOI Listing
April 2019
1 Read

Non-Myasthenia Gravis Immune Syndromes and the Thymus: Is There a Role for Thymectomy?

Thorac Surg Clin 2019 May 7;29(2):215-225. Epub 2019 Mar 7.

Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University Hospitals and Clinics, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address:

Thymectomy has long been considered, performed, and discussed for many different nonmyasthenic immune syndromes. Thymectomy is now an established treatment for MG, and has been performed for other immune syndromes with varying degrees of improvement. Although numerous reports document immune syndromes' association with thymoma, few address the role of thymectomy in symptom resolution. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2018.12.008DOI Listing
May 2019
3 Reads

Immunophenotype anomalies predict the development of autoimmune cytopenia in 22q11.2 Deletion Syndrome.

J Allergy Clin Immunol Pract 2019 Mar 25. Epub 2019 Mar 25.

University Department of Pediatrics, Unit of Immune and Infectious Diseases, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Background: patients with 22q11.2DS may develop severe thrombocytopenic purpura (ITP) and hemolytic anemia (AIHA). There are no reliable predictors for the development of hematologic autoimmunity (HA) in these patients. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.03.014DOI Listing
March 2019
1 Read

Serologic problems associated with administration of intravenous immune globulin (IVIg).

Authors:
Donald R Branch

Immunohematology 2019 Jan;35(1):13-15

Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto, Division of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, and the Centre for Innovation, Canadian Blood Services.

Conclusions: Intravenous immune globulin (IVIg) is manufactured from large pools of donor plasma and contains a high diversity of antibodies, primarily IgG. For this reason, IVIg is routinely used as antibody replacement therapy for patients having primary immunodeficiencies. In 1981, IVIg was also found to be a strong immunomodulator of various inflammatory and autoimmune conditions. Read More

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January 2019
1 Read

An immunocompetent patient with a nonsense mutation in NHEJ1 gene.

BMC Med Genet 2019 Mar 21;20(1):45. Epub 2019 Mar 21.

Persian BayanGene Research and Training Center, Shiraz, Iran.

Background: DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damage. DSBs are repaired by homologous recombination or non-homologous end-joining (NHEJ). NHEJ, which is central to the process of V(D)J recombination is the principle pathway for DSB repair in higher eukaryotes. Read More

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http://dx.doi.org/10.1186/s12881-019-0784-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429708PMC
March 2019
1 Read

Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease.

Clin Nucl Med 2019 May;44(5):e372-e374

Pathology, Shiga General Hospital, Moriyama, Japan.

We report a case of splenic marginal zone B-cell lymphoma discovered in a 73-year-old man with cold agglutinin disease. PET/CT revealed splenomegaly with focally intense uptake of F-FDG and diffusely increased bone marrow uptake, which was considered to be secondary to hemolytic anemia. Splenectomy was performed. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002528DOI Listing
May 2019
5 Reads

The First Purine Nucleoside Phosphorylase Deficiency Patient Resembling IgA Deficiency and a Review of the Literature.

Immunol Invest 2019 Mar 19:1-21. Epub 2019 Mar 19.

a Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran, and the University of Medical Science , Tehran , Iran.

Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity. The affected patients usually present with recurrent infections, neurological dysfunction and autoimmune phenomena. In this study, whole-exome sequencing was used to detect mutation in the case suspected of having primary immunodeficiency. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1570249DOI Listing
March 2019
4 Reads
1.903 Impact Factor

Unusually Low Serum Alkaline Phosphatase Activity in a Patient with Acute on Chronic Liver Failure and Hemolysis.

EJIFCC 2019 Mar 1;30(1):99-105. Epub 2019 Mar 1.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 28-year-old male with acute on chronic liver failure (ACLF) and hepatic encephalopathy had deranged liver function with curiously low level (0-15 IU/L) of serum alkaline phosphatase (ALP). Peripheral smear examination suggested hemolytic anemia. The finding of persistent low ALP, after ruling out pre-analytical causes, in ACLF has been reported in Wilson's disease (WD) with/ without autoimmune hemolytic anemia (AIHA). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416816PMC
March 2019
5 Reads

Outcomes and treatment strategies for autoimmunity and hyperinflammation in patients with RAG deficiency.

J Allergy Clin Immunol Pract 2019 Mar 12. Epub 2019 Mar 12.

Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address:

Background: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series.

Objective: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency.

Methods: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.038DOI Listing
March 2019
1 Read

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs.

J Vet Intern Med 2019 Mar 7. Epub 2019 Mar 7.

Davies Veterinary Specialists, Manor Farm Business Park, Huntingdon, United Kingdom.

Immune-mediated hemolytic anemia (IMHA) causes severe anemia in dogs and is associated with considerable morbidity and mortality. Treatment with various immunosuppressive and antithrombotic drugs has been described anecdotally and in previous studies, but little consensus exists among veterinarians as to the optimal regimen to employ and maintain after diagnosis of the disease. To address this inconsistency and provide evidence-based guidelines for treatment of IMHA in dogs, we identified and extracted data from studies published in the veterinary literature. Read More

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http://dx.doi.org/10.1111/jvim.15463DOI Listing
March 2019
3 Reads

[Outcomes of splenectomy in relapsed/refractory autoimmune hemolytic anemia].

Zhonghua Xue Ye Xue Za Zhi 2019 Feb;40(2):132-136

Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

To evaluate the outcomes of splenectomy in the treatment of relapsed/refractory autoimmune hemolytic anemia (AIHA). Retrospective analysis was performed in 30 cases with relapsed/refractory AIHA who were treated with splenectomy in our hospital. The pre- and post-operative blood routine indexes and responses were followed up. Read More

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http://www.hematoline.com/CN121090201902/1117649.htm
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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.02.007DOI Listing
February 2019
6 Reads

Autoimmune Hemolytic Anemia, Erythrophagocytosis and Liver Dysfunction After Cefixime Use for Urinary Tract Infection in a Child.

Indian J Hematol Blood Transfus 2019 Jan 1;35(1):203-204. Epub 2018 Sep 1.

2Department of Intensive Care Unit, Gazi University Medical Faculty, Ankara, Turkey.

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http://dx.doi.org/10.1007/s12288-018-1006-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369064PMC
January 2019
3 Reads

Pembrolizumab-induced Autoimmune Hemolytic Anemia and Hemophagocytic Lymphohistiocytosis in Non-small Cell Lung Cancer.

Intern Med 2019 1;58(5):699-702. Epub 2019 Mar 1.

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.

We herein report a 78-year old man with squamous cell carcinoma of the lungs treated with pembrolizumab. At 10 days after the administration of pembrolizumab, he showed progressive anemia and increased levels of bilirubin. Because the findings of a direct coombs test and cold hemagglutinin were positive, we diagnosed the patient with autoimmune hemolytic anemia and treated him with prednisolone. Read More

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http://dx.doi.org/10.2169/internalmedicine.1001-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443545PMC
April 2019
1 Read

Novel compound heterozygous mutations in the SPTA1 gene, causing hereditary spherocytosis in a neonate with Coombs‑negative hemolytic jaundice.

Mol Med Rep 2019 Apr 8;19(4):2801-2807. Epub 2019 Feb 8.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Hereditary spherocytosis (HS) is a common heterogeneous type of inherited hemolytic anemia characterized by jaundice and splenomegaly. Diagnosis of HS in neonates is considered unreliable, and is generally based on positive family history, spherocytes in peripheral smears, increased osmotic fragility, and jaundice. In the present study, routine laboratory tests, next‑generation sequencing, and Sanger sequencing were applied to diagnose a neonatal patient with Coombs‑negative hemolytic jaundice. Read More

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http://dx.doi.org/10.3892/mmr.2019.9947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423610PMC
April 2019
1 Read

Recurrent Non-immune Fetal Hydrops Associated With IPEX Syndrome.

Pediatr Dev Pathol 2019 Feb 27:1093526619834809. Epub 2019 Feb 27.

1 Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is a clinical syndrome associated with mutations in FOXP3 and consequent abnormalities of T regulatory cells. Affected males typically die in infancy or early childhood from a variety of autoimmune conditions. Reports of recurrent pregnancy loss of male fetuses in these families have been accompanied by descriptions of nonimmune fetal hydrops, with or without additional fetal anomalies. Read More

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http://dx.doi.org/10.1177/1093526619834809DOI Listing
February 2019
1 Read

Prevalence of autoimmune diseases and clinical significance of autoantibody profile: Data from National Institute of Hygiene in Rabat, Morocco.

Hum Immunol 2019 Feb 23. Epub 2019 Feb 23.

Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

Aim: The objective of this study was to explore the prevalence of various autoimmune diseases (AIDs) in a large cohort of patients and to characterize the autoantibody profile in the patients with and without AIDs to confirm the diagnosis and to refine the Moroccan databases.

Patients And Method: Retrospective study was conducted in the Laboratory of autoimmunity National Institute of Hygiene (NIH) of Rabat in Morocco. A total of 3182 consecutive Moroccan patients (2183 females and 999 males) whose sera were tested for 14 autoantibody profile between 2010 and 2016. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.012DOI Listing
February 2019
5 Reads

The prevalence and prognostic significance of autoimmune cytopenias in a cohort of Egyptian patients with chronic lymphocytic leukemia.

Hematol Oncol Stem Cell Ther 2019 Feb 20. Epub 2019 Feb 20.

The Hematology Unit, Oncology Center, Mansoura University, Mansoura, Egypt. Electronic address:

Objective/background: The impact of autoimmune cytopenias (AICs) on the chronic lymphocytic leukemia (CLL) clinical course and its prognostic significance remain a matter of controversial debate. This could be due to exclusion of patients with cytopenia from most clinical trials for this particular complication and the lack of standard diagnostic criteria and treatment approaches. We herein evaluate the prevalence and the prognostic significance of AICs among patients with CLL. Read More

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http://dx.doi.org/10.1016/j.hemonc.2019.01.004DOI Listing
February 2019
2 Reads

Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors.

Am J Hematol 2019 May 13;94(5):563-574. Epub 2019 Mar 13.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia (AIHA) is a rare, but often severe, complication of ICPis. We identified 14 patients from nine institutions across the United States who developed ICPi-AIHA. Read More

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http://dx.doi.org/10.1002/ajh.25448DOI Listing
May 2019
4 Reads
3.798 Impact Factor

Immunosensor for the Diagnostics of Autoimmune Hemolytic Anemia (AIHA) Based on Immobilization of a Monoclonal Antibody on a Layer of Silk Fibroin.

J Nanosci Nanotechnol 2019 Jul;19(7):3772-3776

Universidade Estadual Paulista, Instituto de Química, Araraquara, SP 14800-060, Brazil.

The diagnostics of the autoimmune hemolytic anemia (AIHA), a rare disease caused by autoantibody-induced hemolysis, is still prone to false positives for it is based on visual observation in the so-called Direct Coombs test. In this study, we developed a specific IgG hemolysis immunosensor produced with layer-by-layer (LbL) films containing a monoclonal antibody against human immunoglobulin (mAbIMUG) deposited along with a layer of silk fibroin (SF) derived from cocoons. Adsorption of mAbIMUG on a SF layer was confirmed by the fluorescence emission band at 326 nm. Read More

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http://dx.doi.org/10.1166/jnn.2019.16305DOI Listing
July 2019
3 Reads
1.556 Impact Factor

Cold agglutinin disease as a new immune-related adverse event associated with anti-PD-L1s and its treatment with rituximab.

Eur J Cancer 2019 Mar 7;110:21-23. Epub 2019 Feb 7.

APHP, Service de Médecine Interne Immunologie Clinique, Hôpitaux Universitaires Paris Sud, Le Kremlin Bicêtre, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.009DOI Listing
March 2019
3 Reads

[Correlation of IgG Subclass with Blood Cell Parameters in Patients with Autoimmune Hemolytic anemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):197-201

Department of Blood Transfusion, The People, s Hospital of Weifang, Weifang 261041, Shandong Province, China.

Objective: To investigate the correlation of IgG subclasses with blood cell parameters in the patients with autoimmune hemolytic anemia (AIHA).

Methods: Thirty-four patients with AIHA (except C3d types) of immune complex type (IgG+C3d) and single IgG type, including 26 cases of primary AIHA and 8 cases of secondary AIHA from December 2010 to August 2016 in our hospital were selected and enrolled in AIHA group; 30 healthy persons were selected and enrolled in healthy control group. The levels of IgG subclasses in blood plasma were detected by double antibody sandwich ELISA in healthy persons and AIHA patients, at the same time. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.032DOI Listing
February 2019
5 Reads

A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.

Case Rep Obstet Gynecol 2019 14;2019:2093612. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Toyooka Public Hospital, 1094, Tobera, Toyooka City, Hyogo 6680065, Japan.

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). Read More

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http://dx.doi.org/10.1155/2019/2093612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348819PMC
January 2019
2 Reads

Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct.

Case Rep Hematol 2019 9;2019:2089359. Epub 2019 Jan 9.

Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Read More

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https://www.hindawi.com/journals/crihem/2019/2089359/
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http://dx.doi.org/10.1155/2019/2089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343168PMC
January 2019
15 Reads

Abnormal Biodistribution of Tc99m Red Blood Cell Labeled Multi-Gated Acquisition Scan in the Presence of Suspected Cold Agglutinin Disease.

J Nucl Med Technol 2019 Jan 29. Epub 2019 Jan 29.

Walter Reed National Military Medical Center, United States.

Tc-red blood cells (RBCs) labeled multi-gated acquisition (MUGA) scan is a procedure in which the patient's red blood cells (RBCs) are radiolabeled and electrocardiograph (ECG)-gated cardiac scintigraphy is obtained to assess the heart's pumping efficiency. Cold agglutinin disease (CAD), or cold antibody autoimmune hemolytic anemia, is a rare form of autoimmune hemolytic anemia in which the body's immune system attacks and destroys its own red blood cells. This case addresses an altered biodistribution pattern of radiolabeled RBCs in the presence of suspected cold agglutinin disease observed during a MUGA scan. Read More

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http://dx.doi.org/10.2967/jnmt.118.222182DOI Listing
January 2019
3 Reads

Immunohematological and clinical characterizations of mixed autoimmune hemolytic anemia.

Asian J Transfus Sci 2018 Jul-Dec;12(2):99-104

Department of Transfusion Medicine, Apollo Gleneagles Hospitals, Kolkata, West Bengal, India.

Background And Aim: Patients with warm autoimmune hemolytic anemia (AIHA) may carry immunoglobulin (Ig) M antibodies that react at room temperature and are nonpathological, but few may have cold agglutinins that react at or above 30°C and are referred to as "mixed" AIHA (MAIHA). Here, we present our experience on characterizing MAIHA both clinically and serologically.

Materials And Methods: Out of 134 AIHA patients, 13 diagnosed as MAIHA were subjected to detailed immunohematological characterization. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_105_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327768PMC
January 2019
2 Reads

Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases.

Prostate Cancer Prostatic Dis 2019 Jan 28. Epub 2019 Jan 28.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Background: Androgen deprivation therapy (ADT) has been a mainstay of treatment for advanced prostate cancer (PCa), but limited studies have been performed to investigate the association between ADT and autoimmune diseases.

Methods: We conducted a population-based nationwide cohort study of 17,168 patients newly diagnosed with PCa between 1996 and 2013 using the National Health Insurance Research Database (NHIRD) of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were used to investigate the association between ADT use and the risk of autoimmune diseases. Read More

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http://www.nature.com/articles/s41391-019-0130-9
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http://dx.doi.org/10.1038/s41391-019-0130-9DOI Listing
January 2019
19 Reads

Concomitant cryoglobulinemic vasculitis and cold agglutinin disease successfully treated with bortezomib: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14201

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Concomitant cryoglobulinemic vasculitis and cold agglutinin disease (CAD) is an extremely uncommon clinical scenario. The role of bortezomib in the treatment of cryoglobulinemic vasculitis needs further investigation.

Patient Concerns: A 72-year-old Chinese woman presented with a 25-year history of cyanosis of the extremities after cold exposure, which worsened and was accompanied with purpuric skin lesions and proteinuria in recent years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0004
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http://dx.doi.org/10.1097/MD.0000000000014201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358358PMC
January 2019
9 Reads

Neurological Involvement in Childhood Evans Syndrome.

J Clin Immunol 2019 Feb 22;39(2):171-181. Epub 2019 Jan 22.

Centre de Référence National des Cytopénies Autoimmunes de l'Enfant (CEREVANCE), University Hospital of Bordeaux, Bordeaux, France.

Purpose: Immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) are associated in the definition of Evans syndrome (ES). The occurrence of neurological involvement in this population is poorly described and suggests an underlying primary immunodeficiency (PID). We aimed to describe the clinical manifestations, evolution, and PID profiles of these patients. Read More

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http://link.springer.com/10.1007/s10875-019-0594-3
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http://dx.doi.org/10.1007/s10875-019-0594-3DOI Listing
February 2019
8 Reads

Low-dose rituximab in autoimmune hemolytic anemia: 10 years after.

Blood 2019 Feb 22;133(9):996-998. Epub 2019 Jan 22.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano-UOC Ematologia, Milan, Italy; and.

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http://dx.doi.org/10.1182/blood-2018-12-885228DOI Listing
February 2019
3 Reads

Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker.

BMC Infect Dis 2019 Jan 18;19(1):68. Epub 2019 Jan 18.

Sri Jayawardanapura General Hospital, Thalapathpitiya, Nugegoda, Western province, Sri Lanka.

Background: Infectious mononucleosis is one of the main manifestations of Epstein - Barr virus, which is characterized by fever, tonsillar-pharyngitis, lymphadenopathy and atypical lymphocytes. Although 60% of patients with IMN develop cold type antibodies, clinically significant hemolytic anemia with a high ferritin level is very rare and validity of serum ferritin as an important biomarker has not been used frequently.

Case Presentation: 18-year-old girl presented with fever, malaise and sore throat with asymptomatic anemia, generalized lymphadenopathy, splenomegaly and mild hepatitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3722-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339345PMC
January 2019
4 Reads

A 55-Year-Old Man With Cold Agglutinin Disease.

J Emerg Nurs 2019 Jan 14. Epub 2019 Jan 14.

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http://dx.doi.org/10.1016/j.jen.2018.11.016DOI Listing
January 2019
1 Read

Autoimmune Cytopenias Occurring after Treatment with Chemoimmunotherapy for Non-Hodgkin Lymphomas.

Acta Haematol 2019 10;141(2):79-83. Epub 2019 Jan 10.

Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.

Autoimmune diseases, including autoimmune hemolytic anemia and immune thrombocytopenic purpura, have been described in patients with non-Hodgkin lymphoma (NHL) after immunochemotherapy. However, the underlying pathogenesis remains unclear. We examined NHL patients with autoimmune cytopenia and all patients were treated with rituximab-containing therapy. Read More

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http://dx.doi.org/10.1159/000495600DOI Listing
January 2019
3 Reads

Gastric duplication cyst in an adult with autoimmune hemolytic anemia: a case report and review of the literature.

J Med Case Rep 2018 Dec 26;12(1):380. Epub 2018 Dec 26.

Department of Surgical Oncology, Mohamed I University, 30050, Oujda, Morocco.

Background: Gastric duplication cysts are uncommon congenital anomalies found primarily in children and rarely seen in the adult population. Accurate diagnosis of cysts before resection is difficult even using the most advanced imaging techniques.

Case Presentation: In this report, we describe a 28-year-old Moroccan patient with a history of autoimmune hemolytic anemia who presented with an asymptomatic abdominal cystic mass detected during abdominal computed tomography performed before splenectomy. Read More

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http://dx.doi.org/10.1186/s13256-018-1895-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305996PMC
December 2018
4 Reads

Expression of C1q in the serum of patients with non‑severe aplastic anemia, and its association with disease severity.

Mol Med Rep 2019 Feb 12;19(2):1194-1202. Epub 2018 Dec 12.

Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

A type of aplastic anemia (AA), non-severe aplastic anemia (NSAA) is defined as AA that does not meet the diagnostic criteria of severe aplastic anemia (SAA). Complement component 1q (C1q) has an important role in the pathogenesis of various autoimmune diseases; however, the role of C1q in the immune pathogenesis of NSAA is not clear. The current study aimed to determine whether C1q has an important role in the pathogenesis of NSAA. Read More

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http://dx.doi.org/10.3892/mmr.2018.9754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323203PMC
February 2019
4 Reads
1.484 Impact Factor

IgM-mediated Warm Autoimmune Hemolytic Anemia: An Autopsy Report.

Intern Med 2019 Apr 18;58(7):999-1002. Epub 2018 Dec 18.

Department of Internal Medicine, Ako City Hospital, Japan.

A 79-year-old man with Sjögren's syndrome and systemic lupus erythematosus developed acute impaired consciousness and hemolytic anemia. The patient's red blood cells agglutinated spontaneously at 25-37°C. The treatment of red blood cells with 2-mercaptoethanol resulted in the loss of spontaneous agglutination. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1291-18DOI Listing
April 2019
17 Reads

Severe refractory idiopathic warm autoimmune haemolytic anaemia responsive to complement inhibition with eculizumab.

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.

We report a case of severe idiopathic warm autoimmune haemolytic anaemia (wAIHA) which was initially poorly responsive to treatment with corticosteroids, intravenous immunoglobulin, mycophenolate mofetil and rituximab, and required transfusion of more than 30 units of red cells over 12 weeks. Off-label use of the terminal complement pathway inhibitor, eculizumab, led to rapid amelioration of the haemolysis, presumably by the inhibition of an intravascular component, and allowed time for slower acting immunosuppressive agent to take effect. This novel approach warrants further evaluation, given the poor prognosis of multirefractory wAIHA. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22642
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http://dx.doi.org/10.1136/bcr-2018-226429DOI Listing
December 2018
19 Reads

[Systemic lupus erythematosus with acquired hemophilia A: a case report].

Authors:
F Yang Y S Zhou Y Jia

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1108-1111

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Acquired hemophilia A (AHA) is anunusual disease resulting from autoantibodies (inhibitors) against coagulation factor VIII (FVIII) and clinically manifests as bleeding, which sometimes can cause potentially limb-threatening or life-threatening situations. AHA is associated with cancers, auto-immune disorders, infections, dermatologic conditions and certain medications, among which it is commonly secondary to multiple rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), pollymyositis, autoimmune hemolytic anemia and undifferentiated connective tissue disease. In autoimmune diseases, it may be the result of autoantibody producing against FVIII, and some cases of AHA may act as the first manifestation of SLE. Read More

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December 2018
22 Reads

Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial.

Blood 2019 Feb 17;133(9):893-901. Epub 2018 Dec 17.

Department of Clinical Pharmacology and.

Cold agglutinin disease is a difficult-to-treat autoimmune hemolytic anemia in which immunoglobulin M antibodies bind to erythrocytes and fix complement, resulting in predominantly extravascular hemolysis. This trial tested the hypothesis that the anti-C1s antibody sutimlimab would ameliorate hemolytic anemia. Ten patients with cold agglutinin disease participated in the phase 1b component of a first-in-human trial. Read More

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http://dx.doi.org/10.1182/blood-2018-06-856930DOI Listing
February 2019
3 Reads

Immune-mediated hemolytic anemia and thrombocytopenia in clonal B-cell disorders: a review.

Clin Adv Hematol Oncol 2018 Oct;16(10):670-676

Mayo Clinic, Rochester, Minnesota.

Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and treatment of these autoimmune disorders, specifically in the setting of B-cell malignancies. AIHA and ITP are classically associated with chronic lymphocytic leukemia (CLL) but have also been reported in plasmacytic and lymphoproliferative disorders. Read More

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October 2018
1 Read

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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http://dx.doi.org/10.1155/2018/7586719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257899PMC
November 2018
16 Reads

Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature.

Pediatr Blood Cancer 2019 Apr 10;66(4):e27569. Epub 2018 Dec 10.

Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Texas.

Autoimmune cytopenias (AIC) post-hematopoietic stem cell transplant (HSCT) are rare but exceptionally challenging complication. We conducted a comprehensive literature review and identified a pooled incidence of post-HSCT autoimmune hemolytic anemia and/or immune thrombocytopenia of 2.66% (SE = 0. Read More

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http://dx.doi.org/10.1002/pbc.27569DOI Listing
April 2019
4 Reads

Prognosis of autoimmune hemolytic anemia in critically ill patients.

Ann Hematol 2019 Mar 10;98(3):589-594. Epub 2018 Dec 10.

Medical Intensive Care Unit, Saint-Louis Teaching Hospital, AP-HP, Paris, France.

Patients with autoimmune hemolytic anemia (AIHA) may require intensive care unit (ICU) admission. In order to describe the characteristics of AIHA patients in ICU and identify prognosis factors, clinical and biological data from 44 patients admitted in one ICU between 2002 and 2015 were retrospectively analyzed. The main reasons for ICU admission were profound anemia without any organ failure in 19 patients (either for safer transfusion or continuous monitoring only). Read More

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http://dx.doi.org/10.1007/s00277-018-3553-9DOI Listing
March 2019
5 Reads