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Transl Psychiatry 2020 Aug 4;10(1):269. Epub 2020 Aug 4.

Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

Existing work on proteomics has found common biomarkers that are altered in individuals with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current study expands our understanding of these biomarkers by profiling 276 plasma proteins with known involvement in neurobiological processes using the Olink Proseek Multiplex Platform in individuals with both PTSD and MCI compared to either disorder alone and with unaffected controls. Participants were World Trade Center (WTC) responders recruited through the Stony Brook WTC Health Program. Read More

Alzheimers Res Ther 2020 Aug 4;12(1):91. Epub 2020 Aug 4.

Department of Neurology, College of Medicine, National Taiwan University Hospital, National Taiwan University, No. 7 Chung-Shan South Road, Taipei, 10055, Taiwan.

Background: Optimization of vascular risk factor control is emerging as an alternative approach to improve cognitive outcomes in Alzheimer's disease, although its efficacy is still under debate. We aimed to investigate the contribution of vascular risk factors on Alzheimer's biomarkers and conversion rate to dementia in subjects with mild cognitive impairment (MCI) with low cerebral small vessel disease burden.

Methods: Two hundred ninety-five newly diagnosed MCI subjects were enrolled from March 2005 to May 2017 for a cross-sectional assessment of vascular risk factors and Alzheimer's plasma and imaging biomarkers, followed by a cognitive outcome assessment 24 months after enrollment. Read More

Int J Geriatr Psychiatry 2020 Aug 3. Epub 2020 Aug 3.

Mercer Institute for Research on Aging, St James's Hospital, Dublin, Ireland.

Objective: To determine the utility of mild cognitive impairment (MCI) subtypes and number of impaired cognitive domains on initial assessment at predicting progression to dementia in a sample of memory clinic patients over a twenty-year period.

Methods: A retrospective analysis was conducted of those presenting to a memory clinic with MCI from 1 January 1999 to 31 December 2018 inclusive. Those with MCI were broken down into one of the four subtypes using recommended cut-off scores on the Cambridge Cognitive Assessment (CAMCOG). Read More

Rom J Morphol Embryol 2020 ;61(1):61-72

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;

In recent decades, traumatic brain injury (TBI) has become one of the most important health problems worldwide and is a major cause of morbidity, mortality and economic losses. Mild traumatic brain injury (mTBI) is less considered, with clinical underestimation leading to an epidemiological underevaluation of its incidence. Many of the signs and symptoms induced by mTBI are difficult to highlight clinically, especially those related to cognitive, behavioral, or emotional impairment. Read More

Ann Geriatr Med Res 2019 Mar 31;23(1):16-19. Epub 2019 Mar 31.

Depratment of Psychology, Hallym University, Chuncheon, Korea.

Background: Amnestic mild cognitive impairment (aMCI) is highly likely to progress to dementia of the Alzheimer type (DAT). One of the most frequently reported symptoms in aMCI and DAT patients is memory impairment. This study compared the levels of beliefs about memory efficacy and control, cognitive activity, and depression among healthy older adults (OA), patients with aMCI, and patients with DAT. Read More

IEEE Trans Neural Syst Rehabil Eng 2020 Jul 31;PP. Epub 2020 Jul 31.

Mild cognitive impairment (MCI) can be an indicator representing the early stage of Alzheimier's disease (AD). AD, which is the most common form of dementia, is a major public health problem worldwide. Efficient detection of MCI is essential to identify the risks of AD and dementia. Read More

IEEE Trans Neural Syst Rehabil Eng 2020 Jul 8;PP. Epub 2020 Jul 8.

Objective: There has been a constant increase in life expectancy with the advancement of modern medicine. Likewise, dementia has also increased and projected to elevate in the coming decades with the higher expenditure on healthcare. Consequently, it is essential to identify early dementia, e. Read More

IEEE Trans Neural Syst Rehabil Eng 2020 Jun 23;PP. Epub 2020 Jun 23.

The convolutional neural network (CNN) model is an active research topic in the field of EEG signals analysis. However, the classification effect of CNN on EEG signals of amnestic mild cognitive impairment (aMCI) with type 2 diabetes mellitus (T2DM) is not ideal. Even if EEG signals are transformed into multispectral images that are more closely matched with the model, the best classification performance can not be achieved. Read More

Neurobiol Aging 2020 Jul 3;95:26-45. Epub 2020 Jul 3.

College of Medicine and Health, University of Exeter, Exeter, UK. Electronic address:

A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNeuroMed study, which included 89 nondemented controls, 86 patients with Alzheimer's disease, and 109 individuals with mild cognitive impairment, including 38 individuals who progressed to Alzheimer's disease within 1 year. We identified significant differentially methylated regions, including 12 adjacent hypermethylated probes in the HOXB6 gene in Alzheimer's disease, which we validated using pyrosequencing. Read More

Int Psychogeriatr 2020 Jul;32(7):875-880

Global Brain Health Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland.

This report describes the evaluation of the psychometric and clinimetric properties of nine self-report measures completed by informal care partners of individuals with mild cognitive impairment or dementia in Parkinson's disease and dementia with Lewy bodies. One hundred thirty-six care partners completed measures on relationship satisfaction, burden, stress, mood, resilience, health, quality of life, and feelings related to care provision. Psychometric properties, such as internal consistency, convergent validity, floor and ceiling effects, completion rate and data missingness, as well as clinimetric properties, such as time to administer, ease of scoring, readability and availability of the scales, were examined. Read More

Geroscience 2020 Aug 2. Epub 2020 Aug 2.

Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Traumatic brain injury (TBI) and Alzheimer's disease (AD) are prominent neurological conditions whose neural and cognitive commonalities are poorly understood. The extent of TBI-related neurophysiological abnormalities has been hypothesized to reflect AD-like neurodegeneration because TBI can increase vulnerability to AD. However, it remains challenging to prognosticate AD risk partly because the functional relationship between acute posttraumatic sequelae and chronic AD-like degradation remains elusive. Read More

J Parkinsons Dis 2020 Jul 27. Epub 2020 Jul 27.

Department of Health Science, University of Burgos, Burgos, Spain.

Background: The asymmetry of motor manifestations present in Parkinson's disease (PD) suggests the existence of differences between both hemispheres. As a consequence, this asymmetry might contribute to different PD clinical phenotypes.

Objective: To study the relationship between motor symptom laterality with motor, non-motor symptoms (NMS), freezing of gait (FOG), and quality of life (QoL) impairment in PD. Read More

J Alzheimers Dis 2020 Jul 24. Epub 2020 Jul 24.

Departamento de Psicología Experimental, Procesos Cognitivos y Logopedia, Facultad de Psicología, Universidad Complutense de Madrid, España.

Background: Recent research pointed to executive dysfunction as a potential early predictor of the progression of mild cognitive impairment (MCI)-dementia in Alzheimer's clinical syndrome (ACS). Such cognitive impairments account for functional impairments in instrumental activities of daily living (IADL).

Objective: The present study analyzes the contributions of executive functions to predict MCI-dementia progression in ACS. Read More

J Alzheimers Dis 2020 Jul 24. Epub 2020 Jul 24.

Lab of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki (LND, CIRI - AUTh) Makedonia, Hellas, Greece.

Background: The early diagnosis of neurocognitive disorders before the symptoms' onset is the ultimate goal of the scientific community. REMEDES for Alzheimer (R4Alz) is a battery, designed for assessing cognitive control abilities in people with minor and major neurocognitive disorders.

Objective: To investigate whether the R4Alz battery's tasks differentiate subjective cognitive decline (SCD) from cognitively healthy adults (CHA) and mild cognitive impairment (MCI). Read More

J Alzheimers Dis 2020 Jul 24. Epub 2020 Jul 24.

Institute of Internal Medicine and Geriatrics, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Frailty is a condition of increased vulnerability to exogenous and endogenous stressors, which is correlated with aging, functional decline, institutionalization, hospitalization, and mortality. Given the multifaceted nature of frailty, programs aimed at its prevention are recommended to act on multiple domains.

Objective: The present intervention program aimed at assessing the effects of combined physical and cognitive training in older people with mild cognitive impairment (MCI) and at investigating how their frailty status changed over one year of follow-up. Read More

J Alzheimers Dis 2020 Jul 29. Epub 2020 Jul 29.

KUDOH Clinic for Neurosurgery and Neurology, Ota-ku, Tokyo, Japan.

Background: In the treatment of Alzheimer's disease (AD), it is thought to be most effective to intervene at the earliest and mildest stages. For diagnosis at the earliest and mildest stages, it is desirable to use a biomarker that can be detected by a minimally invasive, cost-effective technique. Recent research indicates the potential clinical usefulness of plasma amyloid-β (Aβ) biomarkers in predicting brain Aβ burden at an individual level. Read More

J Alzheimers Dis 2020 Jul 25. Epub 2020 Jul 25.

Department of Medicine and Neurology, Emory University School of Medicine, Atlanta, GA, USA.

Background: African Americans (AA) have a higher Alzheimer's disease (AD) prevalence and report more perceived stress than White Americans. The biological basis of the stress-AD link is unclear. This study investigates the connection between stress and AD biomarkers in a biracial cohort. Read More

Transl Neurodegener 2020 Aug 3;9(1):30. Epub 2020 Aug 3.

Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia can be predicted by clinical features and a combination of biomarkers may increase the predictive power. In the present study, we investigated whether the combination of olfactory function and plasma neuronal-derived exosome (NDE) Aβ can best predict progression to AD dementia.

Methods: 87 MCI patients were enrolled and received the cognitive assessment at 2-year and 3-year follow-up to reevaluate cognition. Read More

J Clin Exp Neuropsychol 2020 Aug 3:1-10. Epub 2020 Aug 3.

Center for Alzheimer's Care, Imaging and Research, Department of Neurology, University of Utah , Salt Lake City, UT, USA.

Introduction: The Independent Living Scales (ILS) is an objective measure of day-to-day functioning, which can be used to aid in diagnosing dementia in older adults with cognitive impairments. However, no studies have examined this measure in individuals with Mild Cognitive Impairment (MCI), a prodromal phase of dementia.

Method: Therefore, we sought to examine three subscales of the ILS (Managing Money, Managing Home and Transportation, Health and Safety) in a sample of 132 individuals with amnestic MCI, focusing on the relationship of the ILS with demographic variables (age, education, sex) and cognitive abilities (assessed with the Repeatable Battery for the Assessment of Neuropsychological Status [RBANS]). Read More

Acta Neurol Scand 2020 Aug 1. Epub 2020 Aug 1.

The Morton Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto.

Background: The presence of subjective cognitive complaints (SCC) as a predictor of cognitive impairment in Parkinson´s disease (PD) has shown conflicting results. Most previous studies only assessed complaints in the memory domain. We investigate the association of SCCs across cognitive domains with development of mild cognitive impairment (PD-MCI) and dementia (PDD) in PD, and to assess agreement between SCCs and objective cognitive impairments in this population. Read More

Int J Nurs Stud 2020 Jul 12;110:103706. Epub 2020 Jul 12.

School of Medicine, Huzhou University, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China. Electronic address:

Background: Exercise is known to prevent cognitive decline. Sleep quality and depression symptoms, which are associated with processing speed, are considered as common mediators in the exercise-cognition putative model. However, these mediating mechanisms have not been empirically tested in an intervention study. Read More

Am J Geriatr Psychiatry 2020 Jul 7. Epub 2020 Jul 7.

Department of Psychiatry, School of Medicine and Dentistry (FVL, AP, BPC), University of Rochester Medical Center, Rochester, NY; Department of Public Health, School of Medicine and Dentistry (BPC), University of Rochester Medical Center, Rochester, NY. Electronic address:

Background And Objectives: Computerized cognitive interventions (CCIs) have been increasingly implemented among older adults with mild cognitive impairment (MCI). However, older individuals' attitudes toward technology may limit CCI engagement. This exploratory-developmental study examined whether a "multi-functional interactive computer system" (MICS), which provides pleasurable activities via computer, would improve attitudes toward computers and in turn increase the efficacy of a subsequent CCI. Read More

Mol Neurobiol 2020 Jul 31. Epub 2020 Jul 31.

Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.

Mild cognitive impairment (MCI) defines an intermediate state between normal ageing and dementia, including Alzheimer's disease (AD). Identification of MCI subjects who will progress to AD (MCI-AD) is today of crucial importance, especially in light of the possible development of new pathogenic therapies. Several evidences suggest that miRNAs could play relevant roles in the biogenesis of AD, and the links between selected miRNAs and specific pathogenic aspects have been partly explored. Read More

J Am Med Dir Assoc 2020 Jul 28. Epub 2020 Jul 28.

Department of Geriatric Medicine, Institute of Ageing, Toulouse University Hospital, Toulouse, France; University of Toulouse III, F-31073, Toulouse, France; Inserm URM 1027, F-31073, Toulouse, France.

Objectives: Neuropsychiatric symptoms (NPS) are a core and troubling feature among patients with Alzheimer disease (AD). Because of growing safety warnings against antipsychotics, the use of antidepressants (ATD) in AD has increased extensively. We investigated the potential long-term associations between ATD exposure and functional and cognitive progression in patients with mild to moderate AD. Read More

Am J Geriatr Psychiatry 2020 Jul 7. Epub 2020 Jul 7.

Department of Psychiatry (AT, SS, CA,EZ, NF, CES, AM, CEM, KPE), University of Oxford, Oxford, UK.

Background: Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms.

Method: 800 community-dwelling older adults were drawn from the Whitehall II cohort. Subjective cognitive complaint inquiry for memory and concentration, a range of neuropsychological tests and multimodal MRI were performed in 2012-2016. Read More

EBioMedicine 2020 Jul 28;58:102881. Epub 2020 Jul 28.

Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Republic of Korea. Electronic address:

Background: We sought to investigate the possible associations of rest-activity patterns with cortical amyloid burden, medial temporal lobe (MTL) neurodegeneration, and cognitive function in patients in the early stage of cognitive impairment.

Methods: Rest-activity patterns were assessed in 100 participants (70 with mild cognitive impairment and 30 with mild dementia) using wrist actigraphy. All participants underwent F-flutemetamol positron emission tomography (PET) imaging to quantify cortical amyloid burden, structural brain magnetic resonance imaging (MRI) to quantify MTL grey matter volume, neuropsychological testing, and clinical diagnosis. Read More

Mult Scler Relat Disord 2020 Jul 23;45:102419. Epub 2020 Jul 23.

Gazi University, Faculty of Medicine, Department of Neurology, Ankara, Turkey.

Background: Cognitive impairment is common in patients with multiple sclerosis (MS). The effects of different exercise trainings on cognitive functions in patients with MS are promising. However, the effects are not yet clear in MS patients with cognitive impairment. Read More

PLoS One 2020 31;15(7):e0236654. Epub 2020 Jul 31.

Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan.

Background: The ability to detect one's own memory capacity and develop strategies based on daily contexts is important for daily activities. The Contextual Memory Test (CMT) assesses self-awareness, self-efficacy, self-perception/evaluation of performance, recall, and strategy use that are associated with daily contexts, and could be a potentially suitable measurement for assessing memory and meta-memory in older adults with and without cognitive impairment. Nevertheless, the test-retest reliability and minimal detectable change (MDC) remain unknown in these individuals. Read More

Aging (Albany NY) 2020 Jul 31;12. Epub 2020 Jul 31.

Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases in blood biochemical indicators related to AD risk factors. We recruited 2180 participants, aged 35-93 years, from communities of four districts in Beijing. Read More

JAMA Netw Open 2020 Jul 1;3(7):e208931. Epub 2020 Jul 1.

Department of Anesthesia, Harvard Medical School, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Importance: Postoperative neurocognitive disorders (PNDs) after surgical procedures are common and may be associated with increased health care expenditures.

Objective: To quantify the economic burden associated with a PND diagnosis in 1 year following surgical treatment among older patients in the United States.

Design, Setting, And Participants: This retrospective cohort study used claims data from the Bundled Payments for Care Improvement Advanced Model from 4285 hospitals that submitted Medicare Fee-for-service (FFS) claims between January 2013 and December 2016. Read More

JMIR Mhealth Uhealth 2020 Jul 31;8(7):e16928. Epub 2020 Jul 31.

Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich, Germany.

Background: Modern technologies, including smartphone apps, have the potential to assist people with cognitive impairment with activities of daily living, allowing them to maintain their independence and reduce carer burden. However, such tools have seen a slow rate of uptake in this population, and data on the acceptability of assistive technologies in this population are limited.

Objective: This pilot study included older adults with cognitive impairment and their carers, and explored the perceived needs for and acceptability of an app that was designed to be a simple assistive tool for activities of daily living. Read More

J Affect Disord 2020 Oct 10;275:268-277. Epub 2020 Jul 10.

Department of Research, Lovisenberg Diaconal Hospital, Norway; Department of Psychology, University of Oslo, Norway.

Background: Major depressive disorder (MDD) is associated with deficits in executive functioning (EF) that may have a detrimental effect on everyday functioning. Despite this, there are no established cognitive remediation interventions available targeting EF in MDD. Hence, the primary aim of the present pre-registered randomized controlled trial was to evaluate the effectiveness of Goal Management Training (GMT), a metacognitive and strategy-based cognitive remediation intervention to improve EF in MDD. Read More

J Affect Disord 2020 Oct 10;275:180-186. Epub 2020 Jul 10.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.36, San Hao Street, Shenyang, Liaoning 110004, China. Electronic address:

Background: There were few studies to examine the associations of food preferences and obesity patterns with the incident mild cognitive impairment (MCI). Therefore, this study aimed to examine the associations of health behaviors, food preferences, and with the incidence of MCI.

Methods: All participants aged ≥ 55 years were potential eligible. Read More

J Geriatr Psychiatry Neurol 2020 Jul 31:891988720944244. Epub 2020 Jul 31.

Laboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.

The aim of the current study was to test the accuracy of practice effects, that is, improvement in test performance due to repeated neuropsychological evaluations, in identifying patients with amnestic mild cognitive impairment (a-MCI) at greater risk of conversion to Alzheimer disease (AD). For this purpose, we conducted a longitudinal study of 54 patients diagnosed with a-MCI at the first assessment and followed-up for 4 years. During this time, 18 patients converted to AD. Read More

Eur J Nucl Med Mol Imaging 2020 Jul 31. Epub 2020 Jul 31.

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, 141 52, Stockholm, Sweden.

Purpose: To assess the clinical impact and incremental diagnostic value of F-fluorodeoxyglucose (FDG-PET) among memory clinic patients with uncertain diagnosis.

Methods: The study population consisted of 277 patients who, despite extensive baseline cognitive assessment, MRI, and CSF analyses, had an uncertain diagnosis of mild cognitive impairment (MCI) (n = 177) or dementia (n = 100). After baseline diagnosis, each patient underwent an FDG-PET, followed by a post-FDG-PET diagnosis formulation. Read More

Front Psychol 2020 7;11:1423. Epub 2020 Jul 7.

Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.

Traumatic brain injury (TBI) can be serious partly due to the challenges of assessing and treating its neurocognitive and affective sequelae. The effects of a single TBI may persist for years and can limit patients' activities due to somatic complaints (headaches, vertigo, sleep disturbances, nausea, light or sound sensitivity), affective sequelae (post-traumatic depressive symptoms, anxiety, irritability, emotional instability) and mild cognitive impairment (MCI, including social cognition disturbances, attention deficits, information processing speed decreases, memory degradation and executive dysfunction). Despite a growing amount of research, study comparison and knowledge synthesis in this field are problematic due to TBI heterogeneity and factors like injury mechanism, age at or time since injury. Read More

Am J Phys Med Rehabil 2020 Jul 22. Epub 2020 Jul 22.

Rehabilitation Centre, Tan Tock Seng Hospital, Singapore 569 766 Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane Australia 4072 Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane Australia 4072 Stroke Theme, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne VIC Australia 3084 NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia Physiotherapy, Melbourne School of Health Sciences, University of Melbourne, Parkville Australia 3052 Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane Australia 4072.

Objective: This study aims to investigate factors related to paretic upper limb use within first 4-weeks post-stroke.

Design: Sixty inpatients within 4-weeks of first-time stroke were stratified by severity defined by Fugl Meyer upper limb score: severe=0-22, moderate=23-50, mild=51-66. All wore a wrist accelerometer on the paretic upper limb (24hours). Read More

Alzheimers Res Ther 2020 Jul 30;12(1):90. Epub 2020 Jul 30.

RTI Health Solutions, Research Triangle Park, NC, USA.

Background: The What Matters Most (WMM) study was initiated to evaluate symptoms, AD-related impacts, treatment-related needs, preferences, and priorities among individuals with or at risk for Alzheimer's disease (AD) and their care partners. The objective of this qualitative study phase was to identify a comprehensive set of concepts of interest that are meaningful to individuals across the AD continuum.

Methods: Interviews were conducted with 60 clinically referred individuals and care partners across 5 AD stages (n = 12 each): group 1 (non-clinically impaired individuals with AD pathology), group 2 (individuals with mild cognitive impairment and AD pathology), group 3 (individuals with mild AD), group 4 (individuals with moderate AD and their care partners), and group 5 (care partners of individuals with severe AD). Read More

Brain Connect 2020 Jul 31. Epub 2020 Jul 31.

Kang Ning Junior College of Nursing, 63356, Department of Early Childhood Care and Education, Taipei, Taiwan;

Background: Alzheimer's disease is associated with impairment of large -scale brain networks, disruption in structural connections and functional disconnection between distant brain regions. While decreased functional connectivity has been thoroughly investigated and reported by existing functional neuroimaging literature, the present study investigated network-based differences due to the structural changes in white matter pathways in Alzheimer's disease patients. We hypothesize that diffusion metrics of disrupted tracts that go through cognitive networks related with intrinsic awareness, motor movement and executive control can be utilized as biomarkers to distinguish prodromal stage from Alzheimer's disease stage. Read More

Alzheimers Dement 2020 Jul 30. Epub 2020 Jul 30.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Introduction: Identifying cognitively normal individuals at high risk for progression to symptomatic Alzheimer's disease (AD) is critical for early intervention.

Methods: An AD risk score was derived using unsupervised machine learning. The score was developed using data from 226 cognitively normal individuals and included cerebrospinal fluid, magnetic resonance imaging, and cognitive measures, and validated in an independent cohort. Read More

Aging Cell 2020 Jul 30:e13189. Epub 2020 Jul 30.

Telethon Institute of Genetics and Medicine, Telethon Foundation, Pozzuoli, Italy.

Autophagy agonists have been proposed to slow down neurodegeneration. Spermidine, a polyamine that acts as an autophagy agonist, is currently under clinical trial for the treatment of age-related memory decline. How Spermidine and other autophagy agonists regulate memory and synaptic plasticity is under investigation. Read More

Sleep 2020 Jul 7. Epub 2020 Jul 7.

Sleep Medicine Unit, La Fe University and Polytechnic Hospital, Valencia, Spain.

Previous studies have demonstrated that sleep-breathing disorders, and especially obstructive sleep apnea (OSA), can be observed in patients with a higher risk of progression to Alzheimer's disease (AD). Recent evidence indicates that cerebrospinal fluid (CSF) AD-biomarkers are associated with OSA. In this study, we investigated these associations in a sample of patients with mild cognitive impairment (MCI), a condition that is considered the first clinical phase of AD, when patients showed biomarkers consistent with AD pathology. Read More

Neurology 2020 Jul 29. Epub 2020 Jul 29.

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.

Objective: To test the hypothesis that periodontal disease would be associated with increased risk for dementia and mild cognitive impairment (MCI) we prospectively assessed dementia/MCI outcomes following a baseline periodontal examination.

Methods: Participants enrolled in the Atherosclerosis Risk in Communities Study with a clinical periodontal examination (or edentulous participants) at visit 4 (1996-1998; mean±SD age=63±6, 55% female, 21% black) and adjudicated dementia outcomes through 2016 were included (n=8,275). A subgroup of 4,559 participants had adjudicated dementia and MCI assessments at visit 5 (2011-2013). Read More

BMC Geriatr 2020 Jul 29;20(1):258. Epub 2020 Jul 29.

Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Box 564, SE-751 22, Uppsala, Sweden.

Background: Discrimination between early-stage dementia and other cognitive impairment diagnoses is central to enable appropriate interventions. Previous studies indicate that dual-task testing may be useful in such differentiation. The objective of this study was to investigate whether dual-task test outcomes discriminate between groups of individuals with dementia disorder, mild cognitive impairment, subjective cognitive impairment, and healthy controls. Read More

Curr Radiopharm 2020 Jul 29. Epub 2020 Jul 29.

Nuclear Medicine and 2 Medical Physics Unit, S. Andrea Hospital, La Spezia. Italy.

Background: To compare visual and semi-quantitative analysis of brain [18F]Florbetaben PET images in Mild Cognitive Impairment (MCI) patients and relate this finding to the degree of ß-amyloid burden.

Methods: A sample of 71 amnestic MCI patients (age 74 ± 7.3 years, Mini Mental State Examination 24. Read More

PLoS One 2020 29;15(7):e0236453. Epub 2020 Jul 29.

Internal Medicine Department, National Research Centre, Cairo, Egypt.

Objectives: To assess the potential value of some miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI) among patients with type2 diabetes mellitus (T2DM) and to identify other risk factors for MCI among them.

Methods: This study enrolled 163 adults with T2DM using face to face interview. Cognitive function with its domains was assessed using Adenbrooke's Cognitive Examination III (ACE III). Read More

J Paediatr Child Health 2020 Jul 29. Epub 2020 Jul 29.

Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Aim: To investigate the association between hearing impairment (HI) and measures of early childhood development in Aboriginal children at age 5 years.

Methods: An observational cohort study (n = 1037) of children aged 4.0-7. Read More

Pilot Feasibility Stud 2020 25;6:108. Epub 2020 Jul 25.

Health and Rehabilitation Institute, AUT University, Auckland, New Zealand.

Background: People living with dementia (PLwD) have a high fall risk as cognitive impairment compromises control of gait and balance. Fall prevention exercises that are effective in healthy older adults may not work for PLwD. Cognitive stimulation therapy (CST) has been shown to improve global cognition in PLwD. Read More

JAMA 2020 Jul 28. Epub 2020 Jul 28.

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.

Importance: There are limitations in current diagnostic testing approaches for Alzheimer disease (AD).

Objective: To examine plasma tau phosphorylated at threonine 217 (P-tau217) as a diagnostic biomarker for AD.

Design, Setting, And Participants: Three cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participants with AD and 47 without AD (dates of enrollment, May 2007-January 2019); the Swedish BioFINDER-2 cohort (cohort 2), including cognitively unimpaired participants (n = 301) and clinically diagnosed patients with mild cognitive impairment (MCI) (n = 178), AD dementia (n = 121), and other neurodegenerative diseases (n = 99) (April 2017-September 2019); and a Colombian autosomal-dominant AD kindred (cohort 3), including 365 PSEN1 E280A mutation carriers and 257 mutation noncarriers (December 2013-February 2017). Read More

IEEE Trans Cybern 2020 Jul 28;PP. Epub 2020 Jul 28.

Deep-learning methods (especially convolutional neural networks) using structural magnetic resonance imaging (sMRI) data have been successfully applied to computer-aided diagnosis (CAD) of Alzheimer's disease (AD) and its prodromal stage [i.e., mild cognitive impairment (MCI)]. Read More