J Eur Acad Dermatol Venereol 2017 Aug 22. Epub 2017 Aug 22.
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
There are three related, clinically defined disorders of DNA repair: xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome (CS).(1) Photosensitivity, neurological/developmental abnormalities, and skin cancer are important pathological features that can be used to distinguish between these three archetypes.(1,2) TTD is a rare, autosomal recessive disease characterized by brittle, sulfur-deficient hair and multisystem abnormalities. Read More