73,654 results match your criteria Cochrane Database of Systematic Reviews[Journal]
Atten Percept Psychophys 2018 Dec 13. Epub 2018 Dec 13.
Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53706, USA.
Recent research suggests that humans perceive quantity using a non-symbolic "number sense." This sense is then thought to provide a foundation for understanding symbolic numbers in formal education. Given this link, there has been interest in the extent to which the approximate number system (ANS) can be improved via dedicated training, as this could provide a route to improving performance in symbolic mathematics. Read More
Eur Arch Otorhinolaryngol 2018 Dec 13. Epub 2018 Dec 13.
Department of Communication Disorders, University of Canterbury, Christchurch, New Zealand.
Purpose: This systematic review appraises and summaries methodology documented in studies using high resolution pharyngeal manometry (HRM) with and without impedance technology (HRIM) in adult populations.
Methods: Four electronic databases CINAHL, EMBASE, MEDLINE, and Cochrane Library were searched up to, and including March 2017. Studies reporting pharyngeal HRM/HRIM for swallowing and/or phonatory assessment, published in peer-reviewed journals in English, German, or Spanish were assessed for the inclusion criteria. Read More
Int Orthop 2018 Dec 13. Epub 2018 Dec 13.
Spine Surgery Center, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao, Nanjing, 210009, Jiangsu, China.
Purpose: We conducted a systematic review and meta-analysis to compare the clinical outcomes of percutaneous endoscopic lumbar discectomy (PELD) and microendoscopic discectomy (MED) for the treatment of lumbar disc herniation (LDH), and to clarify whether PELD is more superior to MED.
Methods: We performed a comprehensive search in the databases of MEDLINE, EMBASE, PubMed, Web of Science, Cochrane database, CNKI, and Wanfang Data to acquire all relevant studies up to July 2018. The searched literatures were then screened according to the strict inclusion and exclusion criteria. Read More
Eur Surg 2018 20;50(6):285-298. Epub 2018 Jul 20.
1Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Background: Non-operative management (NOM) of blunt hepatic and splenic injuries has become popular in haemodynamically stable adult patients, despite uncertainty about efficacy, patient selection, and details of management. Up-to-date strategies and practical recommendations are presented.
Methods: A selective literature search was conducted in PubMed and the Cochrane Library (1989-2016). Read More
Front Pharmacol 2018 28;9:1393. Epub 2018 Nov 28.
Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.
Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Read More
J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.
Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Ludwig Maximilians University München, Munich, Germany
Background: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated.
Methods: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). Read More
JMIR Res Protoc 2018 Dec 13;7(12):e188. Epub 2018 Dec 13.
School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Background: The conduct and publication of scientific research are increasingly open and collaborative. There is growing interest in Web-based platforms that can effectively enable global, multidisciplinary scientific teams and foster networks of scientists in areas of shared research interest. Designed to facilitate Web-based collaboration in research evidence synthesis, TaskExchange highlights the potential of these kinds of platforms. Read More
J Shoulder Elbow Surg 2018 Dec 11. Epub 2018 Dec 11.
Sports Surgery Clinic, Dublin, Ireland.
Background: This study systematically reviewed the evidence in the literature to ascertain the functional outcomes, recurrences rates, and subsequent revision rates after the open Latarjet procedure at a minimum of 10 years of follow-up.
Methods: Two independent reviewers performed the literature search based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the Embase, MEDLINE, and The Cochrane Library Databases. Studies that reported a minimum of 10 years of clinical follow-up after the Latarjet procedure were included. Read More
Lancet 2018 Dec 10. Epub 2018 Dec 10.
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Background: Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Ixazomib is ideally suited for maintenance therapy given its convenient once-weekly oral dosing and low toxicity profile. In this study, we aimed to determine the safety and efficacy of ixazomib as maintenance therapy following ASCT. Read More
Ann Epidemiol 2018 Nov 26. Epub 2018 Nov 26.
Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address:
Purpose: Increasing epidemiologic evidence suggests that diabetes mellitus (DM) may be associated with a decreased risk of glioma. This systematic review assessed whether DM was associated with glioma risk.
Methods: Electronic searches were performed in PubMed, Web of Science, EMBASE, and Cochrane Library databases up to August 30, 2018. Read More
Arthroscopy 2018 Dec 10. Epub 2018 Dec 10.
Department of Orthopaedics, The University of Alabama at Birmingham, Birmingham, Alabama, U.S.A.. Electronic address:
Purpose: To synthesize and report the early clinical and radiographic outcomes associated with subacromial spacer use in patients with massive irreparable rotator cuff tears.
Methods: A systematic search on MEDLINE, Embase, and Cochrane Library databases was performed during February 2018. Included studies were evaluated regarding the level of evidence and quality using the methodological index for nonrandomized studies. Read More
Consult Pharm 2018 Dec;33(12):691-701
: Review the clinical manifestations and treatment of primary Sjögren's syndrome. : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. Read More
Syst Rev 2018 Dec 13;7(1):231. Epub 2018 Dec 13.
School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Background: Stroke secondary prevention guidelines recommend medication prescription and adherence, active education and behavioural counselling regarding lifestyle risk factors. To impact on recurrent vascular events, positive behaviour/s must be adopted and sustained as a lifestyle choice, requiring theoretically informed behaviour change and self-management interventions. A growing number of systematic reviews have addressed complex interventions in stroke secondary prevention. Read More
Lipids Health Dis 2018 Dec 13;17(1):281. Epub 2018 Dec 13.
Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Background: Several meta-analyses have demonstrated that the rs662 polymorphism in Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD). However, it is still uncertain whether this polymorphism is associated with the plasma levels of oxidized low-density lipoprotein (Ox-LDL) and lipids. This meta-analysis is aimed to clarify the relationships between the rs662 polymorphism and plasma levels of Ox-LDL and lipids. Read More
BMC Musculoskelet Disord 2018 Dec 13;19(1):442. Epub 2018 Dec 13.
Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.
Background: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Read More
BMC Cancer 2018 Dec 13;18(1):1248. Epub 2018 Dec 13.
Tianjin Medical university, Tianjin, 300070, China.
Background: Cancer patients' survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some adverse effects on patients' quality of life. The prediction of survival plays a key role in choosing therapeutic modality, and Tokuhashi Score was established as one of the most commonly used predictive systems for spinal metastases. Read More
Int J Audiol 2018 Dec 13:1-4. Epub 2018 Dec 13.
d Emma Children's Hospital, Amsterdam UMC , University of Amsterdam, Pediatric Oncology , Amsterdam , The Netherlands.
This Cochrane Corner features the review entitled "Platinum-induced hearing loss after treatment for childhood cancer" published in 2016. In their review, van As et al. identified 13 cohort studies including 2837 participants with a hearing test after treatment with a platinum-based therapy for different types of childhood cancers. Read More
Medicina (Kaunas) 2018 Dec 12;54(6). Epub 2018 Dec 12.
Department of Biology-Chemistry, Advanced Environmental Research Laboratory, West University of Timisoara, Timisoara, 300086, Romania.
Erratic results have been published concerning the influence of the dietary supplement chitosan used as a complementary remedy to decrease the body weight of overweight and obese people. The published articles mention as secondary possible benefits of usage of chitosan the improvement of blood pressure and serum lipids status. We performed a meta-analysis evaluating body weight, body mass index, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure among overweight and obese patients. Read More
J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.
Department of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D'Annunzio University, 66100 Chieti, Italy.
Evidence has recently emerged on the influence of gender on the immune system. In this systematic review and meta-analysis of phase III randomized clinical trials (RCTs), we explored the impact of gender on survival in patients with advanced cancer treated with immune checkpoint inhibitors (ICIs). We performed a comprehensive search of the literature updated to April 2018, including the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE. Read More
Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.
Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea.
Dietary fat intake is associated with the risk of colorectal cancer (CRC); however, the results of epidemiological studies on this are controversial. Therefore, this study aimed to summarize the available scientific evidence regarding the association between dietary fat and the risk of CRC. We conducted a systematic search of PubMed, Web of Science, and the Cochrane library for articles related to dietary fat and the risk of CRC. Read More
Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.
School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.
The purpose of this systematic review and meta-analysis was to address disparities related to sexual health among students by examining the effectiveness of sexually transmitted infection (STI) preventive interventions in educational settings. PubMed, Medline, Cochrane Library, Public Health Database, and EMBASE databases were used to conduct searches. Information relating to studies, programs, participants, and quantitative outcome variables were extracted. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13548
Department of Orthopedics.
Background: Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors.
Methods: Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13547
Department of Ophthalmology, the First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.
Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13534
Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Study Design: Systematic review and meta-analysis.
Background: Anchor screw fixation and mini-plate fixation are widely used in unilateral open-door laminoplasty. There is a great controversy over the preferred fixation method. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13502
Graduate Institute of Clinical Medicine.
Background: Fascia iliaca compartment block (FICB) provides an analgesic option for positioning before spinal anesthesia in patients suffering from a femur fracture. The evidence supporting FICB is still not well established. The aim of our study is to assess the efficacy and safety of FICB comparing with intravenous analgesic (IVA) on the quality for positioning before spinal anesthesia in participants with a femur fracture. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13482
Acupuncture and massage department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Background: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13481
Department of General Surgery, Nanjing Lishui District People's Hospital, Nanjing, Jiangsu, China.
Background: Dazhu Hongjingtian (DZHJT), also named Herba Rhodiolae, has been frequently introduced for patients with angina pectoris in China. However, the add-on effect of DZHJT in unstable angina pectoris (UAP) has not been systematically evaluated. The purpose of this protocol is to provide the methods used to assess the efficacy and safety of DZHJT as adjuvant therapy for management of UAP. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13453
College of Medicine, Zhengzhou University of Industrial Technology, Zhengzhou, Henan, PR China.
Background: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13445
Division of Gynecologic Oncology, Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA.
Background: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer.
Methods: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13407
Department of Respiratory and Critical Care Medicine.
Objective: Endothelial dysfunction was widely regarded as the initial lesion in the multifactorial pathogenesis of cardiovascular disease (CVD). Serum endocan, a novel endothelial dysfunction biochemical marker, is involved in the development of CVD. Here, we fulfilled a meta-analysis to evaluate the association between CVD and serum endocan levels. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13405
Center of Morphological Experiment, Medical College of Yanbian University.
Background: Atrial fibrillation (AF) is the most common type of heart arrhythmia, but the impact of long-term, high-intensity endurance exercise on the risk of AF remains uncertain.
Methods: PubMed, EMBASE, and Cochrane library databases were searched till Nov 2017 to retrieve the articles. The included studies were summarized, pooled odds ratio (OR) and its 95% confidence interval (CI) were calculated. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13378
Hematology and Oncology Department, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong Province, Doumen District, Zhuhai,China.
Background: An increasing number of studies have recently highlighted the role of zinc finger antisense 1(ZFAS1) as a prognostic marker in cancers. However, these results remain controversial. Hence, a meta-analysis was conducted to further investigate the effects of ZFAS1 expression on clinicopathological features and survival outcomes. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13342
Department of Urology, Institute of Urology, West China Hospital of Sichuan University.
Background: We performed the network meta-analysis (NMA) and systematic review involved all evidence from relevant trials to compare the efficiency and safety of various types of selective serotonin reuptake inhibitors (SSRI) and phosphodiesterase-5 inhibitors (PDE5i) in patients with premature ejaculation (PE).
Methods: We conducted comprehensive searches of peer-reviewed and grey literature. PubMed, the Cochrane Library Central Register of Controlled Trials, Embase were searched for randomized controlled trials published up to June 1, 2017. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13340
Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China.
Background: Preoperative neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR) have been suggested to be correlated with the prognosis of patients with breast cancer (BC). However, the results still remain controversial. Therefore, this study was to further evaluate the prognostic potential of preoperative NLR and dNLR for BC patients using a meta-analysis. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13326
Department of Anesthesiology, Huaihe Hospital, Henan University, Kaifeng, China.
Background: This meta-analysis aimed to evaluate the efficiency and safety of the combined adductor canal block (ACB) with local infiltration anesthesia (LIA) versus LIA alone for pain control after total knee arthroplasty (TKA).
Methods: We searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Google databases from inception to August 2017 to selected studies that comparing the combined ACB with LIA and LIA alone for pain control after TKA. Only randomized controlled trials (RCTs) were included. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13325
Department of General Surgery, People's Hospital of Rizhao, Rizhao, China.
Background: Contrast-enhanced ultrasound (CEUS) is a non-invasive method that has been used in the diagnosis of several diseases. Recently, CEUS has been used in the differentiation of benign and malignant thyroid nodules. However, the performance of CEUS in thyroid nodules has not been studied clearly. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13273
Department of Obstetrics and Gynecology.
Background: Murine double minute 2 homolog (MDM2) plays an important role in the downregulation of P53 tumor suppressor gene. MDM2 inhibits P53 transcriptional activity and thereby results in accelerated tumor formation. Overexpression of MDM2 has been found in several cancer types including endometrial cancer. Read More
Medicine (Baltimore) 2018 Dec;97(49):e12789
Department of General Surgery, First Hospital of Lanzhou University.
Background: To evaluate the clinical outcomes of S-1 plus cisplatin (SC) for the treatment of patients with advanced gastric cancer (AGC).
Methods: A systematic literature search was conducted by searching PubMed, the Cochrane Library, Embase, China Biology Medicine disc (CBMdisc), China National Knowledge Infrastructure (CNKI), and WanFang Database, for all year up to January 2017. Pooled analyses of overall survival (OS), progress-free survival rates, and adverse events were performed. Read More
J Neurosurg Pediatr 2018 Nov 1:1-11. Epub 2018 Nov 1.
OBJECTIVEDrug-resistant epilepsy (DRE) presents a therapeutic challenge in children, necessitating the consideration of multiple treatment options. Although deep brain stimulation (DBS) has been studied in adults with DRE, little evidence is available to guide clinicians regarding the application of this potentially valuable tool in children. Here, the authors present the first systematic review aimed at understanding the safety and efficacy of DBS for DRE in pediatric populations, emphasizing patient selection, device placement and programming, and seizure outcomes. Read More
J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.
OBJECTIVEPrimary intracranial myxomas (PICMs) are extremely rare neoplasms, and their management and prognostic factors remain ambiguous. The authors aimed to elaborate the radiological features, evaluate the risk factors for progression-free survival (PFS), and propose a treatment protocol based on pooled data from cases treated at their institute and those found in the literature.METHODSClinical data from all cases of PICMs treated at the authors' institute and those cases reported in the English-language literature between 1987 and December 2017 were reviewed. Read More
Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.
Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.
Context: Care home residents are at risk of malnutrition owing to reduced food intake, anabolic resistance in aging muscle, and a high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding the effectiveness of a high-protein diet on quality of life or clinical outcomes in care home residents.
Objective: The aim of this review was to evaluate the effectiveness of nonmeat, high-protein supplementation on health-related quality of life (HRQOL) and relevant clinical and nutritional outcomes in older people in a care home setting. Read More
Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.
School of Sports Studies and Nutrition, Faculty of Education, Health and Community, Liverpool John Moores University, Merseyside, United Kingdom.
Context: Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk.
Objective: A systematic review and meta-analyses were conducted to compare the effects of very low, low, and moderate carbohydrate, higher fat diets versus high-carbohydrate, low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults.
Data Sources: Medline, PubMed, Cochrane Central, and CINAHL Plus were searched to identify large randomized controlled trials (n > 100) with duration ≥ 6 months. Read More
J Pain 2018 Dec 10. Epub 2018 Dec 10.
Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL.
Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans, producing tremendous economic burden. While some findings suggest that racial/ethnic minorities experience increased OA pain severity, other studies have shown conflicting results. Read More
J Clin Epidemiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Objective: To compare A Measurement Tool to Assess Systematic Reviews (AMSTAR 2) with a tool to assess risk of bias in systematic reviews (ROBIS) in terms of validity, reliability and applicability.
Study Design And Setting: We analyzed 30 systematic reviews (SRs) that included randomized and non-randomized studies, with Cochrane and non-Cochrane SRs sampled in 1:1 ratio. Four reviewers assessed independently all 30 SRs with AMSTAR2, followed by ROBIS. Read More
J Clin Epidemiol 2018 Dec 10. Epub 2018 Dec 10.
Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, the Netherlands. Electronic address:
Objectives: To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR) based absolute effects in Summary of Findings (SoF) tables have been correctly calculated and reported.
Study Design: We identified all Cochrane cancer intervention reviews that reported a HR for at least one outcome and provided a SoF table, published between January 2011 and December 2017 in the Cochrane Database of Systematic Reviews (CDSR).
Results: In 28 reviews (29%) of 96 included Cochrane reviews absolute effects in the SoF tables were calculated in a correct manner. Read More
PLoS One 2018 13;13(12):e0209023. Epub 2018 Dec 13.
METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), INSERM, UMR 1153, Paris, France.
Background: Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable, for the most commonly prescribed drugs in France.
Methods: We conducted an online study using a crowdsourcing approach among French general practitioners and specialists from September 2016 to August 2017. Read More
Health Technol Assess 2018 Dec;22(72):1-220
Regional Vascular Unit, Royal Liverpool University Hospital, Liverpool, UK.
Background: Endovascular abdominal aortic aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA) is less invasive than open surgery, but may be associated with important complications. Patients receiving EVAR require long-term surveillance to detect abnormalities and direct treatments. Computed tomography angiography (CTA) has been the most common imaging modality adopted for EVAR surveillance, but it is associated with repeated radiation exposure and the risk of contrast-related nephropathy. Read More
J Neurol 2018 Dec 12. Epub 2018 Dec 12.
Department of Neurology, Cerebrovascular Disease Center, People's Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.
Background And Purpose: Cerebral microbleeds (CMBs) are a possible predictor of symptomatic intracranial hemorrhage (sICH) and poor function outcome (PFO). We aimed to investigate the presence of CMBs on increased incidence of sICH and PFO in acute ischemic stroke patients receiving intravenous thrombolysis (IVT) treatment.
Methods: We searched PubMed, EMBASE, and Cochrane Library from 1 January 1997 to 13 May 2018, for relevant studies and calculated the pooled relative risk (RR) for the incidence of sICH and PFO in patients with CMBs versus those without after IVT. Read More
Arch Gynecol Obstet 2018 Dec 12. Epub 2018 Dec 12.
Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.
Purpose: Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
Methods: We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms "ovarian cancer", "endometrial cancer", "cervical cancer", "gynecological cancers" combined with 'elderly', 'cancer', 'clinical trial' and 'geriatric assessment'. Read More
Exp Ther Med 2018 Dec 19;16(6):4873-4878. Epub 2018 Sep 19.
Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.
In recent years, the role of magnetic resonance angiography (MRA) in the diagnosis of Budd-Chiari Syndrome (BCS) has been the focus of various clinical studies. The purpose of the present study was to perform a meta-analysis of the diagnostic performance of MRA in patients with BCS by using digital subtraction angiography as a reference method. The search strategy for relevant research articles was based on the Cochrane Handbook for Systematic Reviews, and literature databases (including PubMed, Medline and China National Knowledge Infrastructure) and reference lists of retrieved studies published from 2000 to 2016 were searched. Read More