73,654 results match your criteria Cochrane Database of Systematic Reviews[Journal]


"Approximate number system" training: A perceptual learning approach.

Atten Percept Psychophys 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53706, USA.

Recent research suggests that humans perceive quantity using a non-symbolic "number sense." This sense is then thought to provide a foundation for understanding symbolic numbers in formal education. Given this link, there has been interest in the extent to which the approximate number system (ANS) can be improved via dedicated training, as this could provide a route to improving performance in symbolic mathematics. Read More

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December 2018

A systematic review of current methodology of high resolution pharyngeal manometry with and without impedance.

Eur Arch Otorhinolaryngol 2018 Dec 13. Epub 2018 Dec 13.

Department of Communication Disorders, University of Canterbury, Christchurch, New Zealand.

Purpose: This systematic review appraises and summaries methodology documented in studies using high resolution pharyngeal manometry (HRM) with and without impedance technology (HRIM) in adult populations.

Methods: Four electronic databases CINAHL, EMBASE, MEDLINE, and Cochrane Library were searched up to, and including March 2017. Studies reporting pharyngeal HRM/HRIM for swallowing and/or phonatory assessment, published in peer-reviewed journals in English, German, or Spanish were assessed for the inclusion criteria. Read More

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December 2018

Comparison of percutaneous endoscopic lumbar discectomy versus microendoscopic discectomy for the treatment of lumbar disc herniation: a meta-analysis.

Int Orthop 2018 Dec 13. Epub 2018 Dec 13.

Spine Surgery Center, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao, Nanjing, 210009, Jiangsu, China.

Purpose: We conducted a systematic review and meta-analysis to compare the clinical outcomes of percutaneous endoscopic lumbar discectomy (PELD) and microendoscopic discectomy (MED) for the treatment of lumbar disc herniation (LDH), and to clarify whether PELD is more superior to MED.

Methods: We performed a comprehensive search in the databases of MEDLINE, EMBASE, PubMed, Web of Science, Cochrane database, CNKI, and Wanfang Data to acquire all relevant studies up to July 2018. The searched literatures were then screened according to the strict inclusion and exclusion criteria. Read More

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December 2018

Non-operative management of blunt hepatic and splenic injuries-practical aspects and value of radiological scoring systems.

Eur Surg 2018 20;50(6):285-298. Epub 2018 Jul 20.

1Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Background: Non-operative management (NOM) of blunt hepatic and splenic injuries has become popular in haemodynamically stable adult patients, despite uncertainty about efficacy, patient selection, and details of management. Up-to-date strategies and practical recommendations are presented.

Methods: A selective literature search was conducted in PubMed and the Cochrane Library (1989-2016). Read More

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Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis.

Front Pharmacol 2018 28;9:1393. Epub 2018 Nov 28.

Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom.

Antipsychotic drugs may lead to side effects such as obesity, diabetes, dyslipidemia, and cardiovascular disease. The current systematic review and network meta-analysis analyzes and provides an update on the clinical performance of these add-ons in comparison to placebo on body weight and body mass index (BMI) reductions. A comprehensive literature search was performed on electronic databases: PubMed (1946-), Embase (1974-), Cochrane library (1992-), and OpenGrey (2000-) until 31 July 2018. Read More

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November 2018

Quantity and Reporting Quality of Kidney Research.

J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Ludwig Maximilians University München, Munich, Germany

Background: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated.

Methods: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). Read More

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December 2018

Facilitating Web-Based Collaboration in Evidence Synthesis (TaskExchange): Development and Analysis.

JMIR Res Protoc 2018 Dec 13;7(12):e188. Epub 2018 Dec 13.

School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Background: The conduct and publication of scientific research are increasingly open and collaborative. There is growing interest in Web-based platforms that can effectively enable global, multidisciplinary scientific teams and foster networks of scientists in areas of shared research interest. Designed to facilitate Web-based collaboration in research evidence synthesis, TaskExchange highlights the potential of these kinds of platforms. Read More

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December 2018

Long-term outcomes of the Latarjet procedure for anterior shoulder instability: a systematic review of studies at 10-year follow-up.

J Shoulder Elbow Surg 2018 Dec 11. Epub 2018 Dec 11.

Sports Surgery Clinic, Dublin, Ireland.

Background: This study systematically reviewed the evidence in the literature to ascertain the functional outcomes, recurrences rates, and subsequent revision rates after the open Latarjet procedure at a minimum of 10 years of follow-up.

Methods: Two independent reviewers performed the literature search based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the Embase, MEDLINE, and The Cochrane Library Databases. Studies that reported a minimum of 10 years of clinical follow-up after the Latarjet procedure were included. Read More

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December 2018

Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial.

Lancet 2018 Dec 10. Epub 2018 Dec 10.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Maintenance therapy following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Ixazomib is ideally suited for maintenance therapy given its convenient once-weekly oral dosing and low toxicity profile. In this study, we aimed to determine the safety and efficacy of ixazomib as maintenance therapy following ASCT. Read More

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December 2018

Does diabetes decrease the risk of glioma? A systematic review and meta-analysis of observational studies.

Ann Epidemiol 2018 Nov 26. Epub 2018 Nov 26.

Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China. Electronic address:

Purpose: Increasing epidemiologic evidence suggests that diabetes mellitus (DM) may be associated with a decreased risk of glioma. This systematic review assessed whether DM was associated with glioma risk.

Methods: Electronic searches were performed in PubMed, Web of Science, EMBASE, and Cochrane Library databases up to August 30, 2018. Read More

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November 2018

Subacromial Spacer Implantation for the Treatment of Massive Irreparable Rotator Cuff Tears: A Systematic Review.

Arthroscopy 2018 Dec 10. Epub 2018 Dec 10.

Department of Orthopaedics, The University of Alabama at Birmingham, Birmingham, Alabama, U.S.A.. Electronic address:

Purpose: To synthesize and report the early clinical and radiographic outcomes associated with subacromial spacer use in patients with massive irreparable rotator cuff tears.

Methods: A systematic search on MEDLINE, Embase, and Cochrane Library databases was performed during February 2018. Included studies were evaluated regarding the level of evidence and quality using the methodological index for nonrandomized studies. Read More

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December 2018

Management of Primary Sjögren's Syndrome.

Consult Pharm 2018 Dec;33(12):691-701

: Review the clinical manifestations and treatment of primary Sjögren's syndrome. : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. Read More

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December 2018

Interventions for behaviour change and self-management in stroke secondary prevention: protocol for an overview of reviews.

Syst Rev 2018 Dec 13;7(1):231. Epub 2018 Dec 13.

School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.

Background: Stroke secondary prevention guidelines recommend medication prescription and adherence, active education and behavioural counselling regarding lifestyle risk factors. To impact on recurrent vascular events, positive behaviour/s must be adopted and sustained as a lifestyle choice, requiring theoretically informed behaviour change and self-management interventions. A growing number of systematic reviews have addressed complex interventions in stroke secondary prevention. Read More

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December 2018

Associations of the PON1 rs662 polymorphism with circulating oxidized low-density lipoprotein and lipid levels: a systematic review and meta-analysis.

Lipids Health Dis 2018 Dec 13;17(1):281. Epub 2018 Dec 13.

Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Background: Several meta-analyses have demonstrated that the rs662 polymorphism in Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD). However, it is still uncertain whether this polymorphism is associated with the plasma levels of oxidized low-density lipoprotein (Ox-LDL) and lipids. This meta-analysis is aimed to clarify the relationships between the rs662 polymorphism and plasma levels of Ox-LDL and lipids. Read More

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December 2018

Infection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis.

BMC Musculoskelet Disord 2018 Dec 13;19(1):442. Epub 2018 Dec 13.

Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Read More

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December 2018

Prognostic effect of factors involved in revised Tokuhashi score system for patients with spinal metastases: a systematic review and Meta-analysis.

BMC Cancer 2018 Dec 13;18(1):1248. Epub 2018 Dec 13.

Tianjin Medical university, Tianjin, 300070, China.

Background: Cancer patients' survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some adverse effects on patients' quality of life. The prediction of survival plays a key role in choosing therapeutic modality, and Tokuhashi Score was established as one of the most commonly used predictive systems for spinal metastases. Read More

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December 2018

Cochrane corner: platinum-induced hearing loss after treatment for childhood cancer.

Int J Audiol 2018 Dec 13:1-4. Epub 2018 Dec 13.

d Emma Children's Hospital, Amsterdam UMC , University of Amsterdam, Pediatric Oncology , Amsterdam , The Netherlands.

This Cochrane Corner features the review entitled "Platinum-induced hearing loss after treatment for childhood cancer" published in 2016. In their review, van As et al. identified 13 cohort studies including 2837 participants with a hearing test after treatment with a platinum-based therapy for different types of childhood cancers. Read More

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December 2018

A Meta-Analysis on Randomised Controlled Clinical Trials Evaluating the Effect of the Dietary Supplement Chitosan on Weight Loss, Lipid Parameters and Blood Pressure.

Medicina (Kaunas) 2018 Dec 12;54(6). Epub 2018 Dec 12.

Department of Biology-Chemistry, Advanced Environmental Research Laboratory, West University of Timisoara, Timisoara, 300086, Romania.

Erratic results have been published concerning the influence of the dietary supplement chitosan used as a complementary remedy to decrease the body weight of overweight and obese people. The published articles mention as secondary possible benefits of usage of chitosan the improvement of blood pressure and serum lipids status. We performed a meta-analysis evaluating body weight, body mass index, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure among overweight and obese patients. Read More

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December 2018

Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Department of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D'Annunzio University, 66100 Chieti, Italy.

Evidence has recently emerged on the influence of gender on the immune system. In this systematic review and meta-analysis of phase III randomized clinical trials (RCTs), we explored the impact of gender on survival in patients with advanced cancer treated with immune checkpoint inhibitors (ICIs). We performed a comprehensive search of the literature updated to April 2018, including the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE. Read More

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December 2018

Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Department of Food and Nutrition, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea.

Dietary fat intake is associated with the risk of colorectal cancer (CRC); however, the results of epidemiological studies on this are controversial. Therefore, this study aimed to summarize the available scientific evidence regarding the association between dietary fat and the risk of CRC. We conducted a systematic search of PubMed, Web of Science, and the Cochrane library for articles related to dietary fat and the risk of CRC. Read More

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December 2018

STI Health Disparities: A Systematic Review and Meta-Analysis of the Effectiveness of Preventive Interventions in Educational Settings.

Int J Environ Res Public Health 2018 Dec 11;15(12). Epub 2018 Dec 11.

School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.

The purpose of this systematic review and meta-analysis was to address disparities related to sexual health among students by examining the effectiveness of sexually transmitted infection (STI) preventive interventions in educational settings. PubMed, Medline, Cochrane Library, Public Health Database, and EMBASE databases were used to conduct searches. Information relating to studies, programs, participants, and quantitative outcome variables were extracted. Read More

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December 2018

Meta-analysis of the prognostic value of long non-coding RNA PVT1 for cancer patients.

Medicine (Baltimore) 2018 Dec;97(49):e13548

Department of Orthopedics.

Background: Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors.

Methods: Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Read More

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December 2018

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility.

Medicine (Baltimore) 2018 Dec;97(49):e13547

Department of Ophthalmology, the First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.

Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. Read More

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December 2018

Comparison of anchor screw fixation versus mini-plate fixation in unilateral expansive open-door laminoplasty for the treatment of multi-level cervical spondylotic myelopathy.

Medicine (Baltimore) 2018 Dec;97(49):e13534

Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Study Design: Systematic review and meta-analysis.

Background: Anchor screw fixation and mini-plate fixation are widely used in unilateral open-door laminoplasty. There is a great controversy over the preferred fixation method. Read More

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December 2018

Fascia iliaca compartment block versus intravenous analgesic for positioning of femur fracture patients before a spinal block: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13502

Graduate Institute of Clinical Medicine.

Background: Fascia iliaca compartment block (FICB) provides an analgesic option for positioning before spinal anesthesia in patients suffering from a femur fracture. The evidence supporting FICB is still not well established. The aim of our study is to assess the efficacy and safety of FICB comparing with intravenous analgesic (IVA) on the quality for positioning before spinal anesthesia in participants with a femur fracture. Read More

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December 2018

Oral oxymatrine for hepatitis B cirrhosis: A systematic review protocol.

Medicine (Baltimore) 2018 Dec;97(49):e13482

Acupuncture and massage department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance. Read More

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December 2018
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Dazhu Hongjingtian (Herba Rhodiolae) for unstable angina pectoris: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13481

Department of General Surgery, Nanjing Lishui District People's Hospital, Nanjing, Jiangsu, China.

Background: Dazhu Hongjingtian (DZHJT), also named Herba Rhodiolae, has been frequently introduced for patients with angina pectoris in China. However, the add-on effect of DZHJT in unstable angina pectoris (UAP) has not been systematically evaluated. The purpose of this protocol is to provide the methods used to assess the efficacy and safety of DZHJT as adjuvant therapy for management of UAP. Read More

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December 2018

Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13453

College of Medicine, Zhengzhou University of Industrial Technology, Zhengzhou, Henan, PR China.

Background: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. Read More

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December 2018

Impact of hospital care volume on clinical outcomes of laparoscopic radical hysterectomy for cervical cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13445

Division of Gynecologic Oncology, Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA.

Background: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer.

Methods: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy. Read More

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December 2018

The higher serum endocan levels may be a risk factor for the onset of cardiovascular disease: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13407

Department of Respiratory and Critical Care Medicine.

Objective: Endothelial dysfunction was widely regarded as the initial lesion in the multifactorial pathogenesis of cardiovascular disease (CVD). Serum endocan, a novel endothelial dysfunction biochemical marker, is involved in the development of CVD. Here, we fulfilled a meta-analysis to evaluate the association between CVD and serum endocan levels. Read More

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December 2018

Atrial fibrillation in athletes and general population: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13405

Center of Morphological Experiment, Medical College of Yanbian University.

Background: Atrial fibrillation (AF) is the most common type of heart arrhythmia, but the impact of long-term, high-intensity endurance exercise on the risk of AF remains uncertain.

Methods: PubMed, EMBASE, and Cochrane library databases were searched till Nov 2017 to retrieve the articles. The included studies were summarized, pooled odds ratio (OR) and its 95% confidence interval (CI) were calculated. Read More

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December 2018

Clinicopathological and prognostic significance of zinc finger antisense 1 overexpression in cancers: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13378

Hematology and Oncology Department, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong Province, Doumen District, Zhuhai,China.

Background: An increasing number of studies have recently highlighted the role of zinc finger antisense 1(ZFAS1) as a prognostic marker in cancers. However, these results remain controversial. Hence, a meta-analysis was conducted to further investigate the effects of ZFAS1 expression on clinicopathological features and survival outcomes. Read More

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December 2018

Comparative efficacy and safety of phosphodiesterase-5 inhibitors with selective serotonin reuptake inhibitors in men with premature ejaculation: A systematic review and Bayesian network meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13342

Department of Urology, Institute of Urology, West China Hospital of Sichuan University.

Background: We performed the network meta-analysis (NMA) and systematic review involved all evidence from relevant trials to compare the efficiency and safety of various types of selective serotonin reuptake inhibitors (SSRI) and phosphodiesterase-5 inhibitors (PDE5i) in patients with premature ejaculation (PE).

Methods: We conducted comprehensive searches of peer-reviewed and grey literature. PubMed, the Cochrane Library Central Register of Controlled Trials, Embase were searched for randomized controlled trials published up to June 1, 2017. Read More

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December 2018

Preoperative elevated neutrophil-to-lymphocyte ratio (NLR) and derived NLR are associated with poor prognosis in patients with breast cancer: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13340

Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China.

Background: Preoperative neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR) have been suggested to be correlated with the prognosis of patients with breast cancer (BC). However, the results still remain controversial. Therefore, this study was to further evaluate the prognostic potential of preoperative NLR and dNLR for BC patients using a meta-analysis. Read More

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December 2018

The efficacy of combined adductor canal block with local infiltration analgesia for pain control after total knee arthroplasty: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13326

Department of Anesthesiology, Huaihe Hospital, Henan University, Kaifeng, China.

Background: This meta-analysis aimed to evaluate the efficiency and safety of the combined adductor canal block (ACB) with local infiltration anesthesia (LIA) versus LIA alone for pain control after total knee arthroplasty (TKA).

Methods: We searched PubMed, Medline, Embase, Web of Science, the Cochrane Library and Google databases from inception to August 2017 to selected studies that comparing the combined ACB with LIA and LIA alone for pain control after TKA. Only randomized controlled trials (RCTs) were included. Read More

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December 2018

The diagnostic accuracy of contrast-enhanced ultrasound for the differentiation of benign and malignant thyroid nodules: A PRISMA compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13325

Department of General Surgery, People's Hospital of Rizhao, Rizhao, China.

Background: Contrast-enhanced ultrasound (CEUS) is a non-invasive method that has been used in the diagnosis of several diseases. Recently, CEUS has been used in the differentiation of benign and malignant thyroid nodules. However, the performance of CEUS in thyroid nodules has not been studied clearly. Read More

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December 2018

Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13273

Department of Obstetrics and Gynecology.

Background: Murine double minute 2 homolog (MDM2) plays an important role in the downregulation of P53 tumor suppressor gene. MDM2 inhibits P53 transcriptional activity and thereby results in accelerated tumor formation. Overexpression of MDM2 has been found in several cancer types including endometrial cancer. Read More

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December 2018
5.723 Impact Factor

The clinical outcomes of S-1 plus cisplatin for patients with advanced gastric cancer: A meta-analysis and systematic review.

Medicine (Baltimore) 2018 Dec;97(49):e12789

Department of General Surgery, First Hospital of Lanzhou University.

Background: To evaluate the clinical outcomes of S-1 plus cisplatin (SC) for the treatment of patients with advanced gastric cancer (AGC).

Methods: A systematic literature search was conducted by searching PubMed, the Cochrane Library, Embase, China Biology Medicine disc (CBMdisc), China National Knowledge Infrastructure (CNKI), and WanFang Database, for all year up to January 2017. Pooled analyses of overall survival (OS), progress-free survival rates, and adverse events were performed. Read More

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December 2018

A systematic review of deep brain stimulation for the treatment of drug-resistant epilepsy in childhood.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEDrug-resistant epilepsy (DRE) presents a therapeutic challenge in children, necessitating the consideration of multiple treatment options. Although deep brain stimulation (DBS) has been studied in adults with DRE, little evidence is available to guide clinicians regarding the application of this potentially valuable tool in children. Here, the authors present the first systematic review aimed at understanding the safety and efficacy of DBS for DRE in pediatric populations, emphasizing patient selection, device placement and programming, and seizure outcomes. Read More

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November 2018

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEPrimary intracranial myxomas (PICMs) are extremely rare neoplasms, and their management and prognostic factors remain ambiguous. The authors aimed to elaborate the radiological features, evaluate the risk factors for progression-free survival (PFS), and propose a treatment protocol based on pooled data from cases treated at their institute and those found in the literature.METHODSClinical data from all cases of PICMs treated at the authors' institute and those cases reported in the English-language literature between 1987 and December 2017 were reviewed. Read More

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November 2018

Effect of nonmeat, high-protein supplementation on quality of life and clinical outcomes in older residents of care homes: a systematic review and meta-analysis.

Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.

Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Context: Care home residents are at risk of malnutrition owing to reduced food intake, anabolic resistance in aging muscle, and a high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding the effectiveness of a high-protein diet on quality of life or clinical outcomes in care home residents.

Objective: The aim of this review was to evaluate the effectiveness of nonmeat, high-protein supplementation on health-related quality of life (HRQOL) and relevant clinical and nutritional outcomes in older people in a care home setting. Read More

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December 2018

Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis.

Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.

School of Sports Studies and Nutrition, Faculty of Education, Health and Community, Liverpool John Moores University, Merseyside, United Kingdom.

Context: Carbohydrate-restricted diets may increase low-density lipoprotein cholesterol and thereby cardiovascular risk.

Objective: A systematic review and meta-analyses were conducted to compare the effects of very low, low, and moderate carbohydrate, higher fat diets versus high-carbohydrate, low-fat diets on low-density lipoprotein cholesterol and other lipid markers in overweight/obese adults.

Data Sources: Medline, PubMed, Cochrane Central, and CINAHL Plus were searched to identify large randomized controlled trials (n > 100) with duration ≥ 6 months. Read More

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December 2018

Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.

J Pain 2018 Dec 10. Epub 2018 Dec 10.

Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL.

Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans, producing tremendous economic burden. While some findings suggest that racial/ethnic minorities experience increased OA pain severity, other studies have shown conflicting results. Read More

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December 2018

Minor differences were found between AMSTAR 2 and ROBIS in the assessment of systematic reviews including both randomized and non-randomized studies.

J Clin Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

Objective: To compare A Measurement Tool to Assess Systematic Reviews (AMSTAR 2) with a tool to assess risk of bias in systematic reviews (ROBIS) in terms of validity, reliability and applicability.

Study Design And Setting: We analyzed 30 systematic reviews (SRs) that included randomized and non-randomized studies, with Cochrane and non-Cochrane SRs sampled in 1:1 ratio. Four reviewers assessed independently all 30 SRs with AMSTAR2, followed by ROBIS. Read More

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December 2018

Methodological review showed correct absolute effect size estimates for time-to-event outcomes in less than one-third of cancer-related systematic reviews.

J Clin Epidemiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, the Netherlands. Electronic address:

Objectives: To evaluate in how many cancer-related Cochrane reviews hazard ratio (HR) based absolute effects in Summary of Findings (SoF) tables have been correctly calculated and reported.

Study Design: We identified all Cochrane cancer intervention reviews that reported a HR for at least one outcome and provided a SoF table, published between January 2011 and December 2017 in the Cochrane Database of Systematic Reviews (CDSR).

Results: In 28 reviews (29%) of 96 included Cochrane reviews absolute effects in the SoF tables were calculated in a correct manner. Read More

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December 2018

Acceptable medication non-adherence: A crowdsourcing study among French physicians for commonly prescribed medications.

PLoS One 2018 13;13(12):e0209023. Epub 2018 Dec 13.

METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), INSERM, UMR 1153, Paris, France.

Background: Achieving good medication adherence is a major challenge for patients with chronic conditions. Our study aimed to assess the Threshold for Unacceptable Risk of Non-adherence (TURN), defined as the threshold at which physicians consider the health risks incurred by patients due to medication non-adherence unacceptable, for the most commonly prescribed drugs in France.

Methods: We conducted an online study using a crowdsourcing approach among French general practitioners and specialists from September 2016 to August 2017. Read More

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December 2018

Contrast-enhanced ultrasound and/or colour duplex ultrasound for surveillance after endovascular abdominal aortic aneurysm repair: a systematic review and economic evaluation.

Health Technol Assess 2018 Dec;22(72):1-220

Regional Vascular Unit, Royal Liverpool University Hospital, Liverpool, UK.

Background: Endovascular abdominal aortic aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA) is less invasive than open surgery, but may be associated with important complications. Patients receiving EVAR require long-term surveillance to detect abnormalities and direct treatments. Computed tomography angiography (CTA) has been the most common imaging modality adopted for EVAR surveillance, but it is associated with repeated radiation exposure and the risk of contrast-related nephropathy. Read More

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December 2018

Pretreatment cerebral microbleeds and symptomatic intracerebral hemorrhage post-thrombolysis: a systematic review and meta-analysis.

J Neurol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurology, Cerebrovascular Disease Center, People's Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.

Background And Purpose: Cerebral microbleeds (CMBs) are a possible predictor of symptomatic intracranial hemorrhage (sICH) and poor function outcome (PFO). We aimed to investigate the presence of CMBs on increased incidence of sICH and PFO in acute ischemic stroke patients receiving intravenous thrombolysis (IVT) treatment.

Methods: We searched PubMed, EMBASE, and Cochrane Library from 1 January 1997 to 13 May 2018, for relevant studies and calculated the pooled relative risk (RR) for the incidence of sICH and PFO in patients with CMBs versus those without after IVT. Read More

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December 2018

Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition.

Arch Gynecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.

Purpose: Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.

Methods: We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms "ovarian cancer", "endometrial cancer", "cervical cancer", "gynecological cancers" combined with 'elderly', 'cancer', 'clinical trial' and 'geriatric assessment'. Read More

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December 2018

Diagnostic accuracy of magnetic resonance angiography for Budd-Chiari syndrome: A meta-analysis.

Exp Ther Med 2018 Dec 19;16(6):4873-4878. Epub 2018 Sep 19.

Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.

In recent years, the role of magnetic resonance angiography (MRA) in the diagnosis of Budd-Chiari Syndrome (BCS) has been the focus of various clinical studies. The purpose of the present study was to perform a meta-analysis of the diagnostic performance of MRA in patients with BCS by using digital subtraction angiography as a reference method. The search strategy for relevant research articles was based on the Cochrane Handbook for Systematic Reviews, and literature databases (including PubMed, Medline and China National Knowledge Infrastructure) and reference lists of retrieved studies published from 2000 to 2016 were searched. Read More

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December 2018