14,163 results match your criteria Cochrane Database of Systematic Reviews[Journal]


Haloperidol discontinuation for people with schizophrenia.

Cochrane Database Syst Rev 2019 Apr 21;4:CD011408. Epub 2019 Apr 21.

Community Mental Health, Counties Manukau Health, Building 6, 17 Lambie Drive,, Manukau, Auckland, New Zealand, 2241.

Background: Schizophrenia is a disabling serious mental illness that can be chronic. Haloperidol, one of the first generation of antipsychotic drugs, is effective in the treatment of schizophrenia but can have adverse side effects. The effects of stopping haloperidol in people with schizophrenia who are stable on their prescription are not well researched in the context of systematic reviews. Read More

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http://dx.doi.org/10.1002/14651858.CD011408.pub2DOI Listing
April 2019
1 Read

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011385. Epub 2019 Apr 19.

Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT.

Background: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. Read More

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http://doi.wiley.com/10.1002/14651858.CD011385.pub3
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http://dx.doi.org/10.1002/14651858.CD011385.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474399PMC
April 2019
1 Read

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472957PMC
April 2019
1 Read

Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus.

Cochrane Database Syst Rev 2019 Apr 18;4:CD012368. Epub 2019 Apr 18.

Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark, 2200.

Background: The number of people with type 2 diabetes mellitus (T2DM) is increasing worldwide. The combination of metformin and sulphonylurea (M+S) is a widely used treatment. Whether M+S shows better or worse effects in comparison with other antidiabetic medications for people with T2DM is still controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD012368.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472662PMC

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.

Cochrane Database Syst Rev 2019 Apr 18;4:CD013308. Epub 2019 Apr 18.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, Oxfordshire, UK, OX2 6GG.

Background: Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes to ease the transition from cigarette smoking to abstinence. It works by reducing the intensity of craving and withdrawal symptoms. Although there is clear evidence that NRT used after smoking cessation is effective, it is unclear whether higher doses, longer durations of treatment, or using NRT before cessation add to its effectiveness. Read More

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http://dx.doi.org/10.1002/14651858.CD013308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470854PMC
April 2019
1 Read

Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis.

Cochrane Database Syst Rev 2019 Apr 18;4:CD009876. Epub 2019 Apr 18.

NHS Lothian, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK, EH16 4SA.

Background: Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with cystic fibrosis. Colonisation with Burkholderia cepacia complex species is linked to a more rapid decline in lung function and increases morbidity and mortality. There remain no objective guidelines for strategies to eradicate Burkholderia cepacia complex in cystic fibrosis lung disease, as these are inherently resistant to the majority of antibiotics and there has been very little research in this area. Read More

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http://doi.wiley.com/10.1002/14651858.CD009876.pub4
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http://dx.doi.org/10.1002/14651858.CD009876.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471232PMC
April 2019
2 Reads

Medical treatment for botulism.

Cochrane Database Syst Rev 2019 Apr 17;4:CD008123. Epub 2019 Apr 17.

Department of Neurology & Neurosurgery, McGill University, Montreal General Hospital - Room L7-313, 1650 Cedar Avenue, Montreal, QC, Canada, H3G 1A4.

Background: Botulism is an acute paralytic illness caused by a neurotoxin produced by Clostridium botulinum. Supportive care, including intensive care, is key, but the role of other medical treatments is unclear. This is an update of a review first published in 2011. Read More

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http://doi.wiley.com/10.1002/14651858.CD008123.pub4
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http://dx.doi.org/10.1002/14651858.CD008123.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468196PMC
April 2019
5 Reads

Screening hysteroscopy in subfertile women and women undergoing assisted reproduction.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012856. Epub 2019 Apr 16.

Department of Reproductive Medicine, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India, 632004.

Background: Screening hysteroscopy in infertile women with unexplained infertility, or prior to intrauterine insemination (IUI) or in vitro fertilisation (IVF) may reveal intrauterine pathology that may not be detected by routine transvaginal ultrasound. Hysteroscopy, whether purely diagnostic or operative may improve reproductive outcomes.

Objectives: To assess the effectiveness and safety of screening hysteroscopy in subfertile women undergoing evaluation for infertility, and subfertile women undergoing IUI or IVF. Read More

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http://dx.doi.org/10.1002/14651858.CD012856.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472583PMC
April 2019
2 Reads

Yoga as part of a package of care versus non-standard care for schizophrenia.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012807. Epub 2019 Apr 16.

Discipline of Physiotherapy, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

Background: Yoga is an ancient body-mind practice which originated in India and is popular in the Western world as a form of relaxation and exercise. It has been of interest for people with schizophrenia to determine the efficacy of yoga delivered as a package of care versus non-standard care.

Objectives: To examine the effects of yoga as part of a package of care versus non-standard care for schizophrenia. Read More

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http://dx.doi.org/10.1002/14651858.CD012807.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466669PMC
April 2019
1 Read

Hepatic late adverse effects after antineoplastic treatment for childhood cancer.

Cochrane Database Syst Rev 2019 Apr 15;4:CD008205. Epub 2019 Apr 15.

Department of Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, PO Box 22660, Amsterdam, Netherlands, 1100 DD.

Background: Survival rates have greatly improved as a result of more effective treatments for childhood cancer. Unfortunately, the improved prognosis has been accompanied by the occurrence of late, treatment-related complications. Liver complications are common during and soon after treatment for childhood cancer. Read More

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http://doi.wiley.com/10.1002/14651858.CD008205.pub3
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http://dx.doi.org/10.1002/14651858.CD008205.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463806PMC
April 2019
3 Reads

Robot-assisted surgery in gynaecology.

Cochrane Database Syst Rev 2019 Apr 15;4:CD011422. Epub 2019 Apr 15.

Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group, 1st Floor Education Centre, Royal United Hospital, Combe Park, Bath, UK, BA1 3NG.

Background: This is an updated merged review of two originally separate Cochrane reviews: one on robot-assisted surgery (RAS) for benign gynaecological disease, the other on RAS for gynaecological cancer. RAS is a relatively new innovation in laparoscopic surgery that enables the surgeon to conduct the operation from a computer console, situated away from the surgical table. RAS is already widely used in the United States for hysterectomy and has been shown to be feasible for other gynaecological procedures. Read More

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http://doi.wiley.com/10.1002/14651858.CD011422.pub2
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http://dx.doi.org/10.1002/14651858.CD011422.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464707PMC
April 2019
2 Reads

Barriers and facilitators to the implementation of doctor-nurse substitution strategies in primary care: a qualitative evidence synthesis.

Cochrane Database Syst Rev 2019 Apr 15;4:CD010412. Epub 2019 Apr 15.

Department of Public Health, Hamadan University of Medical Sciences, Mahdeieh Ave. Hamadan, Iran, Hamadan, Hamadan, Iran.

Background: Having nurses take on tasks that are typically conducted by doctors (doctor-nurse substitution, a form of 'task-shifting') may help to address doctor shortages and reduce doctors' workload and human resource costs. A Cochrane Review of effectiveness studies suggested that nurse-led care probably leads to similar healthcare outcomes as care delivered by doctors. This finding highlights the need to explore the factors that affect the implementation of strategies to substitute doctors with nurses in primary care. Read More

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http://dx.doi.org/10.1002/14651858.CD010412.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462850PMC

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

Cochrane Database Syst Rev 2019 Apr 12;4:CD012680. Epub 2019 Apr 12.

School of Psychology, Deakin University Geelong, 221 Burwood Highway, Burwood, VIC, Victoria, Australia, 3025.

Background: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD. Read More

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http://doi.wiley.com/10.1002/14651858.CD012680.pub2
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http://dx.doi.org/10.1002/14651858.CD012680.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459769PMC
April 2019
2 Reads

First aid glucose administration routes for symptomatic hypoglycaemia.

Cochrane Database Syst Rev 2019 Apr 11;4:CD013283. Epub 2019 Apr 11.

Centre for Evidence-Based Practice (CEBaP), Belgian Red Cross, Motstraat 42, Mechelen, Belgium, 2800.

Background: Hypoglycaemia is a common occurrence in people with diabetes but can also result from an imbalance in glucose homeostasis in the absence of diabetes. The best enteral route for glucose administration for suspected hypoglycaemia in a first aid situation is unknown.

Objectives: To assess the effects of first aid glucose administration by any route appropriate for use by first-aid providers (buccal, sublingual, oral, rectal) for symptomatic hypoglycaemia. Read More

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http://doi.wiley.com/10.1002/14651858.CD013283.pub2
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http://dx.doi.org/10.1002/14651858.CD013283.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459163PMC
April 2019
4 Reads

Community-based antibiotic delivery for possible serious bacterial infections in neonates in low- and middle-income countries.

Cochrane Database Syst Rev 2019 Apr 11;4:CD007646. Epub 2019 Apr 11.

Division of Neonatology, University of Toronto, Toronto, Canada.

Background: The recommended management for neonates with a possible serious bacterial infection (PSBI) is hospitalisation and treatment with intravenous antibiotics, such as ampicillin plus gentamicin. However, hospitalisation is often not feasible for neonates in low- and middle-income countries (LMICs). Therefore, alternative options for the management of neonatal PSBI in LMICs needs to be evaluated. Read More

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http://dx.doi.org/10.1002/14651858.CD007646.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458055PMC
April 2019
2 Reads

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries.

Cochrane Database Syst Rev 2019 Apr 10;4:CD012018. Epub 2019 Apr 10.

Cochrane Oral Health, Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Coupland Building 3, Oxford Road, Manchester, UK, M13 9PL.

Background: Dental caries (tooth decay) and periodontal diseases (gingivitis and periodontitis) affect the majority of people worldwide, and treatment costs place a significant burden on health services. Decay and gum disease can cause pain, eating and speaking difficulties, low self-esteem, and even tooth loss and the need for surgery. As dental plaque is the primary cause, self-administered daily mechanical disruption and removal of plaque is important for oral health. Read More

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http://dx.doi.org/10.1002/14651858.CD012018.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457073PMC
April 2019
2 Reads

Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack.

Cochrane Database Syst Rev 2019 Apr 9;4:CD011427. Epub 2019 Apr 9.

NIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, University of Exeter, St Luke's Campus, South Cloisters (Room 3.09), Exeter, Devon, UK, EX1 2LU.

Background: Rapid and accurate detection of stroke by paramedics or other emergency clinicians at the time of first contact is crucial for timely initiation of appropriate treatment. Several stroke recognition scales have been developed to support the initial triage. However, their accuracy remains uncertain and there is no agreement which of the scales perform better. Read More

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http://dx.doi.org/10.1002/14651858.CD011427.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455894PMC
April 2019
2 Reads

Glucocorticosteroids for people with alcoholic hepatitis.

Cochrane Database Syst Rev 2019 Apr 9;4:CD001511. Epub 2019 Apr 9.

Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK-2100.

Background: Alcoholic hepatitis is a form of alcoholic liver disease characterised by steatosis, necroinflammation, fibrosis, and complications to the liver. Typically, alcoholic hepatitis presents in people between 40 and 50 years of age. Alcoholic hepatitis can be resolved if people abstain from drinking, but the risk of death will depend on the severity of the liver damage and abstinence from alcohol. Read More

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http://dx.doi.org/10.1002/14651858.CD001511.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455893PMC
April 2019
1 Read

WITHDRAWN: Interventions for guttate psoriasis.

Cochrane Database Syst Rev 2019 Apr 9;4:CD001213. Epub 2019 Apr 9.

The Dermatology Centre, The University of Manchester, Salford Royal NHS Foundation Trust, Stott Lane, Salford, Manchester, UK, M6 8HD.

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. Very little specific evidence-based guidance is available in standard texts to help make rational decisions about treatment options.

Objectives: To assess the effectiveness of treatments for guttate psoriasis. Read More

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http://doi.wiley.com/10.1002/14651858.CD001213.pub2
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http://dx.doi.org/10.1002/14651858.CD001213.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454586PMC
April 2019
1 Read

Non-antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis.

Cochrane Database Syst Rev 2019 Apr 8;4:CD011541. Epub 2019 Apr 8.

Department of Dermatology, Université François-Rabelais de Tours, Tours, France, 37044.

Background: Guttate psoriasis displays distinctive epidemiological and clinical features, making it a separate entity within the heterogeneous group of cutaneous psoriasis types. It is associated with genetic, immune, and environmental factors (such as stress and infections) and usually arises in younger age groups (including children, teenagers, and young adults). There is currently no cure for psoriasis, but various treatments can help to relieve the symptoms and signs. Read More

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http://dx.doi.org/10.1002/14651858.CD011541.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452774PMC

Physical activity for lower urinary tract symptoms secondary to benign prostatic obstruction.

Cochrane Database Syst Rev 2019 Apr 6;4:CD012044. Epub 2019 Apr 6.

Postgraduate Program on Society, Technology and Public Policies (SOTEPP); Department of Medicine, Centro Universitário Tiradentes (UNIT/AL), Av. Comendador Gustavo Paiva, 5017, Cruz das Almas, Maceió, AL, Brazil, 57038-000.

Background: Lower urinary tract symptoms caused by benign prostatic obstruction (LUTS/BPO) represents one of the most common clinical complaints in men. Physical activity might represent a viable first-line intervention for treating LUTS/BPO.

Objectives: To assess the effects of physical activity for lower urinary tract symptoms caused by benign prostatic obstruction (LUTS/BPO). Read More

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http://dx.doi.org/10.1002/14651858.CD012044.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450803PMC
April 2019
2 Reads

Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema.

Cochrane Database Syst Rev 2019 Apr 5;4:CD005351. Epub 2019 Apr 5.

Queen's University, Kingston, Canada.

Background: Non-invasive positive pressure ventilation (NPPV) has been used to treat respiratory distress due to acute cardiogenic pulmonary oedema (ACPE). We performed a systematic review and meta-analysis update on NPPV for adults presenting with ACPE.

Objectives: To evaluate the safety and effectiveness of NPPV compared to standard medical care (SMC) for adults with ACPE. Read More

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http://dx.doi.org/10.1002/14651858.CD005351.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449889PMC
April 2019
2 Reads

Peer support for people with schizophrenia or other serious mental illness.

Cochrane Database Syst Rev 2019 Apr 4;4:CD010880. Epub 2019 Apr 4.

Nethersole School of Nursing, The Chinese University of Hong Kong, 8/F., Esther Lee Building, Chung Chi Campus, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Background: Peer support provides the opportunity for peers with experiential knowledge of a mental illness to give emotional, appraisal and informational assistance to current service users, and is becoming an important recovery-oriented approach in healthcare for people with mental illness.

Objectives: To assess the effects of peer-support interventions for people with schizophrenia or other serious mental disorders, compared to standard care or other supportive or psychosocial interventions not from peers.

Search Methods: We searched the Cochrane Schizophrenia Group's Study-Based Register of Trials on 27 July 2016 and 4 July 2017. Read More

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http://dx.doi.org/10.1002/14651858.CD010880.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448529PMC
April 2019
3 Reads

Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B.

Cochrane Database Syst Rev 2019 Apr 3;4:CD013089. Epub 2019 Apr 3.

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chaoyang District, Beijing, China, 100029.

Background: Hepatitis B virus (HBV) infection, a liver disease caused by hepatitis B virus, may lead to serious complications such as cirrhosis and hepatocellular carcinoma. People with HBV infection may have co-infections including HIV and other hepatitis viruses (hepatitis C or D), and co-infection may increase the risk of all-cause mortality. Chronic HBV infection increases morbidity and psychological stress and is an economic burden on people with chronic hepatitis B and their families. Read More

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http://dx.doi.org/10.1002/14651858.CD013089.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446139PMC
April 2019
4 Reads

Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews.

Cochrane Database Syst Rev 2019 Apr 3;4:CD011890. Epub 2019 Apr 3.

School of Physiotherapy, The University of Notre Dame Australia, 19 Mouat Street (PO Box 1225), Fremantle, Western Australia, Australia, 6959.

Background: Chronic pain, considered to be pain lasting more than three months, is a common and often difficult to treat condition that can significantly impact upon function and quality of life. Treatment typically includes pharmacological and non-pharmacological approaches. Transcutaneous electrical nerve stimulation (TENS) is an adjunct non-pharmacological treatment commonly recommended by clinicians and often used by people with pain. Read More

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http://dx.doi.org/10.1002/14651858.CD011890.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446021PMC
April 2019
4 Reads

Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents.

Cochrane Database Syst Rev 2019 Apr 2;4:CD011118. Epub 2019 Apr 2.

Cochrane Pain, Palliative and Supportive Care Group, Pain Research Unit, Churchill Hospital, Oxford, UK.

Background: This is the first update of a review published in 2015, Issue 1. Chronic pain is common during childhood and adolescence and is associated with negative outcomes, such as increased severity of pain, reduced function, and low mood. Psychological therapies, traditionally delivered face-to-face with a therapist, are efficacious at reducing pain intensity and disability. Read More

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http://dx.doi.org/10.1002/14651858.CD011118.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445568PMC
April 2019
4 Reads

Herbal medicinal products or preparations for neuropathic pain.

Cochrane Database Syst Rev 2019 Apr 2;4:CD010528. Epub 2019 Apr 2.

School of Health Sciences, Ulster University, Jordanstown campus, Shore Road, Newtownabbey, County Antrim, UK, BT37 0QB.

Background: Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), or surgery. Evidence suggests that people suffering from neuropathic pain are likely to seek alternative modes of pain relief such as herbal medicinal products due to adverse events brought about by current pharmacological agents used to treat neuropathic pain. This review includes studies in which participants were treated with herbal medicinal products (topically or ingested) who had experienced neuropathic pain for at least three months. Read More

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http://dx.doi.org/10.1002/14651858.CD010528.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445324PMC
April 2019
4 Reads

WITHDRAWN: Gluten- and casein-free diets for autistic spectrum disorder.

Cochrane Database Syst Rev 2019 Apr 2;4:CD003498. Epub 2019 Apr 2.

Department of Clinical Psychology, Derbyshire Children's Hospital, Uttoxeter Road, Derby, UK, DE22 3NE.

Background: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism.

Objectives: To determine the efficacy of gluten and/or casein free diets as an intervention to improve behaviour, cognitive and social functioning in individuals with autism. Read More

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http://dx.doi.org/10.1002/14651858.CD003498.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445047PMC
April 2019
4 Reads

Support during pregnancy for women at increased risk of low birthweight babies.

Cochrane Database Syst Rev 2019 Apr 1;4:CD000198. Epub 2019 Apr 1.

Monash Nursing and Midwifery, Monash University, Wellington Road, Clayton, Victoria, Australia, 3800.

Background: Studies consistently show a relationship between social disadvantage and low birthweight. Many countries have programmes offering special assistance to women thought to be at risk for giving birth to a low birthweight infant. These programmes, collectively referred to in this review as additional social support, may include emotional support, which gives a person a feeling of being loved and cared for, tangible/instrumental support, in the form of direct assistance/home visits, and informational support, through the provision of advice, guidance and counselling. Read More

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http://dx.doi.org/10.1002/14651858.CD000198.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443020PMC
April 2019
5 Reads

Long-term antibiotics for preventing recurrent urinary tract infection in children.

Cochrane Database Syst Rev 2019 Apr 1;4:CD001534. Epub 2019 Apr 1.

Centre for Kidney Research, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, Australia, 2145.

Background: Urinary tract infection (UTI) is common in children. Symptoms include fever, lethargy, anorexia, and vomiting. UTI is caused by Escherichia coli in over 80% of cases and treatment is a course of antibiotics. Read More

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http://dx.doi.org/10.1002/14651858.CD001534.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442022PMC
April 2019
3 Reads

Constraint-induced movement therapy in children with unilateral cerebral palsy.

Cochrane Database Syst Rev 2019 Apr 1;4:CD004149. Epub 2019 Apr 1.

Victorian Paediatric Rehabilitation Service, Monash Children's Hospital, 246 Clayton Rd, Clayton, Victoria, Australia, 3168.

Background: Unilateral cerebral palsy (CP) is a condition that affects muscle control and function on one side of the body. Children with unilateral CP experience difficulties using their hands together secondary to disturbances that occur in the developing fetal or infant brain. Often, the more affected limb is disregarded. Read More

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http://doi.wiley.com/10.1002/14651858.CD004149.pub3
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http://dx.doi.org/10.1002/14651858.CD004149.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442500PMC
April 2019
6 Reads

Supplemental perioperative intravenous crystalloids for postoperative nausea and vomiting.

Cochrane Database Syst Rev 2019 Mar 29;3:CD012212. Epub 2019 Mar 29.

Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 10 West Victoria, 1276 South Park Street, Halifax, NS, Canada, B3H 2Y9.

Background: Postoperative nausea and vomiting (PONV) is a common complication following general anaesthesia. It may be associated with patient dissatisfaction, increased costs of treatment, and unintended admission to hospital.Supplemental intravenous crystalloid administration in the perioperative period may be a simple intervention to prevent PONV. Read More

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http://dx.doi.org/10.1002/14651858.CD012212.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440702PMC
March 2019
3 Reads

Benzodiazepines versus placebo for panic disorder in adults.

Cochrane Database Syst Rev 2019 Mar 28;3:CD010677. Epub 2019 Mar 28.

Department of Psychiatry II, Ulm University, Ludwig-Heilmeyer-Str. 2, Guenzburg, Germany, 89312.

Background: Panic disorder is characterised by recurrent unexpected panic attacks consisting of a wave of intense fear that reaches a peak within a few minutes. Panic disorder is a common disorder, with an estimated lifetime prevalence of 1% to 5% in the general population and a 7% to 10% prevalence in primary care settings. Its aetiology is not fully understood and is probably heterogeneous. Read More

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http://dx.doi.org/10.1002/14651858.CD010677.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438660PMC
March 2019
2 Reads

Lifestyle changes in women with polycystic ovary syndrome.

Cochrane Database Syst Rev 2019 03 28;3:CD007506. Epub 2019 Mar 28.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Victoria, Australia, 3168.

Background: Polycystic ovary syndrome (PCOS) affects 8% to 13% of reproductive-aged women and is associated with reproductive and metabolic dysfunction. Obesity worsens the presentation of PCOS and weight management (weight loss, maintenance or prevention of excess weight gain) is proposed as an initial treatment strategy, best achieved through lifestyle changes incorporating diet, exercise and behavioural interventions.

Objectives: To assess the effectiveness of lifestyle treatment in improving reproductive, anthropometric (weight and body composition), metabolic and quality of life factors in PCOS. Read More

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http://dx.doi.org/10.1002/14651858.CD007506.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438659PMC
March 2019
1 Read

Brivaracetam add-on therapy for drug-resistant epilepsy.

Cochrane Database Syst Rev 2019 03 28;3:CD011501. Epub 2019 Mar 28.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Lower Lane, Liverpool, UK, L9 7LJ.

Background: Epilepsy is one of the most common neurological disorders. It is estimated that up to 30% of patients with epilepsy continue to have epileptic seizures despite treatment with an antiepileptic drug. These patients are classified as drug-resistant and require treatment with a combination of multiple antiepileptic drugs. Read More

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http://doi.wiley.com/10.1002/14651858.CD011501.pub2
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http://dx.doi.org/10.1002/14651858.CD011501.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437881PMC
March 2019
3 Reads

Ab interno trabecular bypass surgery with iStent for open-angle glaucoma.

Cochrane Database Syst Rev 2019 03 28;3:CD012743. Epub 2019 Mar 28.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E6009, Baltimore, Maryland, USA, 21205.

Background: Glaucoma is a leading cause of irreversible blindness worldwide. In early stages, glaucoma results in progressive loss of peripheral (side) vision; in later stages, it results in loss of central vision leading to blindness. Elevated intraocular pressure (IOP) is the only known modifiable risk factor for glaucoma. Read More

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http://dx.doi.org/10.1002/14651858.CD012743.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437719PMC
March 2019
2 Reads

Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery.

Cochrane Database Syst Rev 2019 03 27;3:CD004318. Epub 2019 Mar 27.

Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA.

Background: This an update of the review first published in 2009.Major abdominal and pelvic surgery carries a high risk of venous thromboembolism (VTE). The efficacy of thromboprophylaxis with low molecular weight heparin (LMWH) administered during the in-hospital period is well-documented, but the optimal duration of prophylaxis after surgery remains controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD004318.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450215PMC
March 2019
1 Read

Mindfulness-based stress reduction for women diagnosed with breast cancer.

Cochrane Database Syst Rev 2019 03 27;3:CD011518. Epub 2019 Mar 27.

Cochrane Haematological Malignancies, Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Background: Breast cancer is the most common cancer in women. Diagnosis and treatment may drastically affect quality of life, causing symptoms such as sleep disorders, depression and anxiety. Mindfulness-based stress reduction (MBSR) is a programme that aims to reduce stress by developing mindfulness, meaning a non-judgmental, accepting moment-by-moment awareness. Read More

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http://doi.wiley.com/10.1002/14651858.CD011518.pub2
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http://dx.doi.org/10.1002/14651858.CD011518.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436161PMC
March 2019
13 Reads

Biomedical risk assessment as an aid for smoking cessation.

Cochrane Database Syst Rev 2019 03 26;3:CD004705. Epub 2019 Mar 26.

Center for Primary Care and Public Health, University of Lausanne, Rue du Bugnon 44, Lausanne, Switzerland, 1011.

Background: A possible strategy for increasing smoking cessation rates could be to provide smokers with feedback on the current or potential future biomedical effects of smoking using, for example, measurement of exhaled carbon monoxide (CO), lung function, or genetic susceptibility to lung cancer or other diseases.

Objectives: The main objective was to determine the efficacy of providing smokers with feedback on their exhaled CO measurement, spirometry results, atherosclerotic plaque imaging, and genetic susceptibility to smoking-related diseases in helping them to quit smoking.

Search Methods: For the most recent update, we searched the Cochrane Tobacco Addiction Group Specialized Register in March 2018 and ClinicalTrials. Read More

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http://doi.wiley.com/10.1002/14651858.CD004705.pub5
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http://dx.doi.org/10.1002/14651858.CD004705.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434771PMC
March 2019
12 Reads

Negative pressure wound therapy for surgical wounds healing by primary closure.

Cochrane Database Syst Rev 2019 03 26;3:CD009261. Epub 2019 Mar 26.

National Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, 170 Kessels Road, Brisbane, Queensland, Australia, 4111.

Background: Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). While existing evidence for the effectiveness of NPWT remains uncertain, new trials necessitated an updated review of the evidence for the effects of NPWT on postoperative wounds healing by primary closure.

Objectives: To assess the effects of negative pressure wound therapy for preventing surgical site infection in wounds healing through primary closure. Read More

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http://dx.doi.org/10.1002/14651858.CD009261.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434581PMC

Vaccines for preventing rotavirus diarrhoea: vaccines in use.

Cochrane Database Syst Rev 2019 03 25;3:CD008521. Epub 2019 Mar 25.

Editorial & Methods Department, Cochrane, St Albans House, 57 - 59 Haymarket, London, UK, SW1Y 4QX.

Background: Rotavirus results in more diarrhoea-related deaths in children under five years than any other single agent in countries with high childhood mortality. It is also a common cause of diarrhoea-related hospital admissions in countries with low childhood mortality. Rotavirus vaccines that have been prequalified by the World Health Organization (WHO) include a monovalent vaccine (RV1; Rotarix, GlaxoSmithKline), a pentavalent vaccine (RV5; RotaTeq, Merck), and, more recently, another monovalent vaccine (Rotavac, Bharat Biotech). Read More

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http://dx.doi.org/10.1002/14651858.CD008521.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434239PMC

Cognitive training for people with mild to moderate dementia.

Cochrane Database Syst Rev 2019 03 25;3:CD013069. Epub 2019 Mar 25.

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, 34-54 Poplar Road, Parkville, Melbourne, Victoria, Australia, 3052.

Background: Cognitive impairment, a defining feature of dementia, plays an important role in the compromised functional independence that characterises the condition. Cognitive training (CT) is an approach that uses guided practice on structured tasks with the direct aim of improving or maintaining cognitive abilities.

Objectives: • To assess effects of CT on cognitive and non-cognitive outcomes for people with mild to moderate dementia and their caregivers. Read More

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http://dx.doi.org/10.1002/14651858.CD013069.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433473PMC
March 2019
2 Reads

Systematic screening and assessment of psychosocial well-being and care needs of people with cancer.

Cochrane Database Syst Rev 2019 Mar 26;3:CD012387. Epub 2019 Mar 26.

Research Group Health Care, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Limburg, Belgium, 3500.

Background: Receiving a diagnosis of cancer and the subsequent related treatments can have a significant impact on an individual's physical and psychosocial well-being. To ensure that cancer care addresses all aspects of well-being, systematic screening for distress and supportive care needs is recommended. Appropriate screening could help support the integration of psychosocial approaches in daily routines in order to achieve holistic cancer care and ensure that the specific care needs of people with cancer are met and that the organisation of such care is optimised. Read More

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http://dx.doi.org/10.1002/14651858.CD012387.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433560PMC

Betahistine for tinnitus.

Cochrane Database Syst Rev 2018 Dec 28;12:CD013093. Epub 2018 Dec 28.

Department of Otorhinolaryngology & Head and Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.

Background: Tinnitus is a symptom defined as the perception of sound in the absence of an external source. In England alone there are an estimated ¾ million general practice consultations every year where the primary complaint is tinnitus, equating to a major burden on healthcare services. Clinical management strategies include education and advice, relaxation therapy, tinnitus retraining therapy, cognitive behavioural therapy, sound enrichment using ear-level sound generators or hearing aids, and drug therapies to manage co-morbid symptoms such as sleep difficulties, anxiety or depression. Read More

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http://dx.doi.org/10.1002/14651858.CD013093.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433459PMC
December 2018
3 Reads

Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer.

Cochrane Database Syst Rev 2019 03 23;3:CD009786. Epub 2019 Mar 23.

Department of Obstetrics and Gynaecology, Academic Medical Center, Meibergdreef 9, Amsterdam, Netherlands, 1105 AZ.

Background: This is an update of a Cochrane Review that was originally published in 2014, Issue 2.The presence of residual disease after primary debulking surgery is a highly significant prognostic factor in women with advanced ovarian cancer. In up to 60% of women, residual tumour of > 1 cm is left behind after primary debulking surgery (defined as suboptimal debulking). Read More

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http://dx.doi.org/10.1002/14651858.CD009786.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432174PMC
March 2019
2 Reads

Linezolid for drug-resistant pulmonary tuberculosis.

Cochrane Database Syst Rev 2019 03 20;3:CD012836. Epub 2019 Mar 20.

Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool, UK.

Background: Linezolid was recently re-classified as a Group A drug by the World Health Organization (WHO) for treatment of multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), suggesting that it should be included in the regimen for all patients unless contraindicated. Linezolid use carries a considerable risk of toxicity, with the optimal dose and duration remaining unclear. Current guidelines are mainly based on evidence from observational non-comparative studies. Read More

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http://dx.doi.org/10.1002/14651858.CD012836.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426281PMC
March 2019
1 Read

Memantine for dementia.

Cochrane Database Syst Rev 2019 03 20;3:CD003154. Epub 2019 Mar 20.

Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 4, Main Hospital, Room 4401C, Oxford, Oxfordshire, UK, OX3 9DU.

Background: Memantine is a moderate affinity uncompetitive antagonist of glutamate NMDA receptors. It is licensed for use in moderate and severe Alzheimer's disease (AD); in the USA, it is also widely used off-label for mild AD.

Objectives: To determine efficacy and safety of memantine for people with dementia. Read More

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http://dx.doi.org/10.1002/14651858.CD003154.pub6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425228PMC
March 2019
1 Read

Electroconvulsive therapy for treatment-resistant schizophrenia.

Cochrane Database Syst Rev 2019 03 19;3:CD011847. Epub 2019 Mar 19.

General Adult Psychiatry, Nottinghamshire Healthcare NHS Trust, Bassetlaw Hospital, Worksop, South Yorkshire, UK, S81 0BD.

Background: Electroconvulsive therapy (ECT) involves the induction of a seizure by the administration of an electrical stimulus via electrodes usually placed bilaterally on the scalp and was introduced as a treatment for schizophrenia in 1938. However, ECT is a controversial treatment with concerns about long-term side effects such a memory loss. Therefore, it is important to determine its clinical efficacy and safety for people with schizophrenia who are not responding to their treatment. Read More

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http://dx.doi.org/10.1002/14651858.CD011847.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424225PMC
March 2019
1 Read

Family-based prevention programmes for alcohol use in young people.

Cochrane Database Syst Rev 2019 03 19;3:CD012287. Epub 2019 Mar 19.

School of Medicine and Public Health, University of Newcastle, Hunter Medical Research Institute, Callaghan, NSW, Australia, 2308.

Background: Alcohol use in young people is a risk factor for a range of short- and long-term harms and is a cause of concern for health services, policy-makers, youth workers, teachers, and parents.

Objectives: To assess the effectiveness of universal, selective, and indicated family-based prevention programmes in preventing alcohol use or problem drinking in school-aged children (up to 18 years of age).Specifically, on these outcomes, the review aimed:• to assess the effectiveness of universal family-based prevention programmes for all children up to 18 years ('universal interventions');• to assess the effectiveness of selective family-based prevention programmes for children up to 18 years at elevated risk of alcohol use or problem drinking ('selective interventions'); and• to assess the effectiveness of indicated family-based prevention programmes for children up to 18 years who are currently consuming alcohol, or who have initiated use or regular use ('indicated interventions'). Read More

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http://dx.doi.org/10.1002/14651858.CD012287.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423557PMC

Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.

Cochrane Database Syst Rev 2019 03 19;3:CD011000. Epub 2019 Mar 19.

Effective Care Research Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Nnewi, Anambra State, Nigeria.

Background: This is an updated version of the original Cochrane review published in Issue 5, 2015.Cervical cancer is the fourth most common cancer among women worldwide, with estimated 569,847 new diagnoses and 311,365 deaths per year. However, incidence and stage at diagnosis vary greatly between geographic areas and are largely dependent on the availability of a robust population screening programme. Read More

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http://dx.doi.org/10.1002/14651858.CD011000.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423555PMC
March 2019
1 Read