611 results match your criteria Coccidioidomycosis Infectious Diseases

Congenital Coccidioidomycosis: A Case Report and Review of the Literature.

J Pediatric Infect Dis Soc 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Coccidioidomycosis in neonates is rare and the acquisition of disease in this age group is not well understood. Congenital coccidioidomycosis is very rare, usually associated with coccidioidal placentitis. Only a handful of cases of congenital coccidioidomycosis have been described in the literature. Read More

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Coccidioidomycosis in Allogeneic Stem Cell Transplant Recipients: Case Series and Review of the Literature.

J Fungi (Basel) 2021 Apr 27;7(5). Epub 2021 Apr 27.

Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ 85054, USA.

is an endemic fungus of the Southwest United States that causes the disease coccidioidomycosis. Immunocompromised persons are at increased risk for severe infection and dissemination. One such population is allogeneic bone marrow transplant (allo-HCT) recipients, but accounts of coccidioidal infection in these patients have rarely been documented. Read More

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Long-Term Infectious Complications of Kidney Transplantation.

Clin J Am Soc Nephrol 2021 Apr 20. Epub 2021 Apr 20.

Division of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio

Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. Opportunistic infections most frequently present in the first 12 months post-transplant and can be modulated on prior exposures and use of prophylaxis. Read More

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Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Division of Infectious Diseases, Naval Medical Center, San Diego, CA 92134, USA.

We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection. Read More

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Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis.

Antimicrob Agents Chemother 2021 Mar 29. Epub 2021 Mar 29.

California Institute for Medical Research, San Jose, CA, USA.

spp. are important pathogens in endemic regions and new treatment options are needed. Isavuconazonium sulfate (ISAVUSULF) and fluconazole (FLU) were evaluated in experimental disseminated coccidioidomycosis to characterize drug exposures associated with efficacy. Read More

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Cavitary Coccidioidomycosis: Impact of azole antifungal therapy.

Med Mycol 2021 Mar 16. Epub 2021 Mar 16.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic Hospital, Phoenix, Arizona, 85054, USA.

Approximately 5 to 15% of patients with pulmonary coccidioidomycosis subsequently develop pulmonary cavities. These cavities may resolve spontaneously over a number of years; however, some cavities never close, and a small proportion causes complications such as hemorrhage, pneumothorax or empyema. The impact of azole antifungal treatment on coccidioidal cavities has not been studied. Read More

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Clinical performance of a point-of-care Coccidioides antibody test in dogs.

J Vet Intern Med 2021 Mar 6;35(2):965-969. Epub 2021 Mar 6.

Department of Medicine and Epidemiology, University of California-Davis, Davis, California, USA.

Background: Point-of-care (POC) Coccidioides antibody assays may provide veterinarians with rapid and accurate diagnostic information.

Objectives: To determine the agreement of a POC lateral flow assay (LFA), sona Coccidioides (IMMY, Norman, Oklahoma) with the current diagnostic standard, the immunodiffusion assay (agar gel immunodiffusion [AGID]; Coccidioidomycosis Serology Laboratory, University of California, Davis, California).

Animals: Forty-eight sera specimens from 48 dogs. Read More

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Health Care Providers' Testing Practices for Coccidioidomycosis and Histoplasmosis in Patients With Community-Acquired Pneumonia-United States, 2020.

Open Forum Infect Dis 2021 Feb 18;8(2):ofab020. Epub 2021 Jan 18.

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Laboratory testing is required to distinguish coccidioidomycosis and histoplasmosis from other types of community-acquired pneumonia (CAP). In this nationwide survey of 1258 health care providers, only 3.7% reported frequently testing CAP patients for coccidioidomycosis and 2. Read More

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February 2021

Fatal coccidioidomycosis involving the lungs, brain, tongue, and adrenals in a cirrhotic patient. An autopsy case.

IDCases 2021 14;23:e01049. Epub 2021 Jan 14.

Medical Service, Division of Infectious Diseases, South Texas Veterans Healthcare System, 7400 Merton Minter Blvd, San Antonio, TX, 78229, United States.

In this paper, we describe a case of fatal disseminated coccidioidomycosis (CM). The patient was a 44-year old male with a history of cirrhosis who presented with altered mental status, cough, and an enlarged, ulcerated tongue. On evaluation, the patient was found to have coccidioidal infection of the tongue, lungs, and brain. Read More

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January 2021

Coccidioidomycosis: a review.

J Investig Med 2021 Feb;69(2):316-323

Infectious Diseases, Kern Medical Center, Bakersfield, California, USA

Coccidioidomycosis is a fungal infection of the Western hemisphere that is endemic to the soil in areas with limited rainfall. Human and animal infections result with inhalation of arthroconidia. Most often, this is an asymptomatic event. Read More

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February 2021

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations.

Antimicrob Agents Chemother 2021 03 18;65(4). Epub 2021 Mar 18.

Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, Sacramento, California, USA

We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson's , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1. Read More

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Coccidioidomycosis in patients with various inflammatory disorders treated with tumor necrosis factor α inhibitors.

Med Mycol 2021 Jan 8. Epub 2021 Jan 8.

Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, Arizona.

Coccidioides fungi are found primarily in the southwestern United States and are the cause of coccidioidomycosis. Tumor necrosis factor α inhibitors (TNFIs) are therapies for autoimmune and inflammatory conditions; their association with coccidioidomycosis is not well characterized. We aimed to determine the prevalence and characteristics of coccidioidomycosis among TNFI recipients with different inflammatory disorders at a tertiary care center. Read More

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January 2021

Differential Thermotolerance Adaptation between Species of .

J Fungi (Basel) 2020 Dec 14;6(4). Epub 2020 Dec 14.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.

Coccidioidomycosis, or Valley fever, is caused by two species of dimorphic fungi. Based on molecular phylogenetic evidence, the genus contains two reciprocally monophyletic species: and . However, phenotypic variation between species has not been deeply investigated. Read More

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December 2020

Coccidioidomycosis: Changing Concepts and Knowledge Gaps.

Neil M Ampel

J Fungi (Basel) 2020 Dec 10;6(4). Epub 2020 Dec 10.

Department of Infectious Diseases, Medicine and Immunobiology University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA.

Although first described more than 120 years ago, much remains unknown about coccidioidomycosis. In this review, new information that has led to changing concepts will be reviewed and remaining gaps in our knowledge will be discussed. In particular, new ideas regarding ecology and epidemiology, problems and promises of diagnosis, controversies over management, and the possibility of a vaccine will be covered. Read More

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December 2020

Regional Analysis of Coccidioidomycosis Incidence - California, 2000-2018.

MMWR Morb Mortal Wkly Rep 2020 Dec 4;69(48):1817-1821. Epub 2020 Dec 4.

Infectious Diseases Branch, Center for Infectious Diseases, California Department of Public Health.

Coccidioidomycosis (Valley fever) is an infection caused by the soil-dwelling fungus Coccidioides spp., which usually manifests as a mild self-limited respiratory illness or pneumonia but can result in severe disseminated disease and, rarely, death (1,2). In California, coccidioidomycosis incidence increased nearly 800% from 2000 (2. Read More

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December 2020

Sociodemographic Factors Associated with Patients Hospitalized for Coccidioidomycosis in California and Arizona, State Inpatient Database 2005-2011.

Epidemiol Infect 2020 Nov 20:1-28. Epub 2020 Nov 20.

Division of Infectious Diseases Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center.

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November 2020

Coccidioidomycosis in a reference center in Northeast Brazil: clinical/epidemiological profile and most common radiological findings.

Rev Soc Bras Med Trop 2020 21;53:e20200249. Epub 2020 Oct 21.

Universidade de Fortaleza, Faculdade de Medicina, Fortaleza, CE, Brasil.

Introduction: Coccidioidomycosis, a disease caused by Coccidioides immitis or Coccidioides posadasii, is endemic in arid climatic regions in Northeast Brazil. Its prevalence is higher among young adult males living in rural areas. Existing literature about this disease in Ceará, a Northeast Brazilian state, are scarce. Read More

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October 2020

Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice.

Infect Immun 2020 Dec 15;89(1). Epub 2020 Dec 15.

Department of Medicine, Division of Infectious Disease, U.C. San Diego School of Medicine, La Jolla, California, USA

The pathology of human coccidioidomycosis is granulomatous inflammation with many neutrophils surrounding ruptured spherules, but the chemotactic pathways that draw neutrophils into the infected tissues are not known. We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret macrophage inflammatory protein 2 (MIP-2), which suggested that CXC ELR+ chemokines might be involved in neutrophil recruitment To test that hypothesis, we intranasally infected interleukin-8R2 (IL-8R2) ()-deficient mice on a BALB/c background with RS. IL-8R2-deficient mice had fewer neutrophils in infected lungs than controls, but unexpectedly the IL-8R2-deficient mice had fewer organisms in their lungs than the control mice. Read More

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December 2020

Valley Fever (Coccidioidomycosis) Awareness - California, 2016-2017.

MMWR Morb Mortal Wkly Rep 2020 Oct 23;69(42):1512-1516. Epub 2020 Oct 23.

Infectious Diseases Branch, Division of Communicable Disease Control, California Department of Public Health.

Valley fever (coccidioidomycosis) is endemic in the southwestern United States and caused by inhalation of Coccidioides spp. fungal spores from soil or dust; 97% of U.S. Read More

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October 2020

Miliary pattern pulmonary infiltrates in a diabetic patient: Coccidioidomycosis.

IDCases 2020 1;22:e00977. Epub 2020 Oct 1.

Department of Medicine, Division of Infectious Diseases, University of California San Francisco-Fresno, Fresno, CA, United States.

This is a case of miliary coccidioidomycosis. This case illustrates the importance of early suspicion for coccidioidomycosis in patients from an endemic area. Early identification and recognition of the disease are important to attain early therapy and disease control. Read More

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October 2020

Symptoms in blastomycosis, coccidioidomycosis, and histoplasmosis versus other respiratory illnesses in commercially insured adult outpatients, United States, 2016-2017.

Clin Infect Dis 2020 Oct 14. Epub 2020 Oct 14.

National Center for Emerging and Zoonotic Infectious Diseases, Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Blastomycosis, coccidioidomycosis, and histoplasmosis cause various symptoms and syndromes, which may present similarly to other infections such as bacterial or viral community-acquired pneumonia, influenza, and tuberculosis.

Methods: We used the IBM® MarketScan® Research Databases to identify adult outpatients with International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis codes during 2016-2017 for blastomycosis; coccidioidomycosis; histoplasmosis; pneumonia (viral, bacterial, Streptococcus pneumoniae, and unspecified pneumonia); influenza; tuberculosis; and other lower and upper respiratory infections. We compared symptoms on and in the 90 days before diagnosis between patients with these diagnosis codes. Read More

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October 2020

Coccidioidomycosis in llamas and alpacas diagnosed at the University of California, Davis (1990-2016).

Med Mycol 2020 Sep 17. Epub 2020 Sep 17.

Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Given the predisposition of South American camelids to coccidioidomycosis, we sought to describe the disease presentation in alpacas and llamas and identify potential risk factors for these species. The records of 224 llamas and alpacas that were tested for Coccidioides infection using immunodiffusion serology at the Coccidioidomycosis Serology Laboratory of the University of California, Davis, between 1990 and 2016 were examined; of those, 46 alpacas and 42 llamas had positive test results. The remaining 99 alpacas and 37 llamas were used as control groups. Read More

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September 2020

Spiromastigoides asexualis: Phylogenetic Analysis and Evaluation as a Cause of False-Positive DNA Probe Test Results.

J Clin Microbiol 2020 11 18;58(12). Epub 2020 Nov 18.

Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, Davis, CA, USA

This is the first case of human infection, and it notably gave a false-positive DNA probe laboratory result. We further investigated other isolates as a cause of false-positive testing results, their phylogenetic relationship, and their susceptibility profiles to clinically available antifungal agents. Other isolates also resulted in positive DNA probe results, while species other than did not. Read More

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November 2020

[Infections of the lungs in returning travellers].

N Menner T Cronen

Pneumologe (Berl) 2020 Aug 13:1-10. Epub 2020 Aug 13.

Medizinische Klinik m. S. Infektiologie und Pneumologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Deutschland.

Travellers to foreign countries can acquire infections with pathogens that are not endemic in Germany. In light of the steadily increasing foreign travel these infections in returning travellers are of growing importance. Older travellers and those with underlying diseases constitute a special risk group. Read More

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Natural History of Disseminated Coccidioidomycosis: Examination of the VA-Armed Forces Database.

Clin Infect Dis 2020 Aug 11. Epub 2020 Aug 11.

Valley Fever Center for Excellence, University of Arizona College of Medicine-Tucson, Tucson, Arizona.

Background: The natural history of non-central nervous system (CNS) disseminated coccidioidomycosis (DCM) has not been previously characterized. The historical VA-Armed Forces coccidioidomycosis patient group provides a unique cohort of patients not treated with standard antifungal therapy allowing for characterization of the natural history of coccidioidomycosis.

Methods: We conducted a retrospective study of 531 VA-Armed Forces coccidioidomycosis patients diagnosed between 1955-1958 and followed to 1966. Read More

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Comparative Study of Newer and Established Methods of Diagnosing Coccidioidal Meningitis.

J Fungi (Basel) 2020 Aug 4;6(3). Epub 2020 Aug 4.

IMMY, Inc., 2701 Corporate Center Drive, Norman, OK 73069, USA.

Meningitis is the most devastating form of coccidioidomycosis. A convenient, rapid diagnostic method could result in early treatment and avoid many meningitis complications. We studied cerebrospinal fluid (CSF) samples in patients with documented coccidioidal meningitis, and controls, with complement fixation (CF), immunodiffusion (ID) (the "classical" assays), lateral flow assays (LFA; one-strip and two-strip), and two enzyme immunoassays (EIA). Read More

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Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review.

Semin Respir Crit Care Med 2020 Aug 6;41(4):522-537. Epub 2020 Jul 6.

Indiana University, School of Medicine, Pulmonary Critical Care Medicine, Thoracic Transplantation Program, Indianapolis, Indiana.

In endemic areas, dimorphic fungal infections due to , and account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significance due to established areas of endemicity in all six inhabited continents, an increasingly interconnected world of travelers and transported goods, and a changing epidemiology as a result of global heating and anthropomorphic land utilization. Read More

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Fungal prostatitis due to endemic mycoses and Cryptococcus: A multicenter case series.

Prostate 2020 09 22;80(12):1006-1011. Epub 2020 Jun 22.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Background: Fungal prostatitis is exceedingly rare with mostly case reports.

Methods: Electronic medical records at three medical centers were searched for cases of fungal prostatitis due to endemic mycoses and Cryptococcus over the preceding 10 years.

Results: Seven cases were identified from 105 600 prostate biopsies within the Southern California Permanente Medical Group for an incidence of 0. Read More

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September 2020

Coccidioidomycosis in Patients Treated With Ruxolitinib.

Open Forum Infect Dis 2020 Jun 19;7(6):ofaa167. Epub 2020 May 19.

Division of Infectious Diseases, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

We report 8 cases of coccidioidomycosis associated with ruxolitinib treatment. Among 135 patients living in the coccidioidal-endemic region receiving ruxolitinib, 5 cases were diagnosed after starting and 4 had extrathoracic dissemination. Periodic serological screening while on ruxolitinib is warranted for patients residing in the coccidioidal-endemic region. Read More

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Simultaneous coccidioidomycosis and phaeohyphomycosis in a kidney transplant recipient: A case report and literature review.

Transpl Infect Dis 2020 Dec 25;22(6):e13365. Epub 2020 Jun 25.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Advances in solid organ transplantation have improved the survival of end-stage organ disease at the expense of an increased risk for opportunistic infections. Unusual clinical presentations and the possibility of concurrent infections make diagnosing invasive fungal infection (IFI) more difficult. Here, we present a case of simultaneous vertebral infection caused by Coccidioides immitis-posadasii and subcutaneous phaeohyphomycosis due to Nigrograna mackinnonii in a kidney transplant recipient. Read More

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December 2020