3,336 results match your criteria Coccidioidomycosis Infectious Diseases


Coccidioidomycosis in Alpacas in the Southwestern United States.

Transbound Emerg Dis 2018 Dec 2. Epub 2018 Dec 2.

Valley Fever Center for Excellence, The University of Arizona, Tucson, AZ.

An anonymous web-based survey of alpaca owners was used to learn more about the clinical presentation, diagnosis, and treatment of coccidioidomycosis in alpacas in the United States. Thirty-seven owners, with 1,117 alpacas, completed the survey. Over 4% of alpacas included in the study were diagnosed with coccidioidomycosis between 2005 and 2016 (5 post mortem, 46 clinically). Read More

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December 2018

Selection of Specific Peptides for spp. Obtained from Antigenic Fractions through SDS-PAGE and Western Blot Methods by the Recognition of Sera from Patients with Coccidioidomycosis.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd. Mx. 04510, Mexico.

Antigenic fractions of 100, 50, 37, and 28 kDa obtained through the SDS-PAGE method that were more frequently recognized by anti- antibodies in the sera of coccidioidomycosis patients were selected using western blotting. Subsequently, these bands were sequenced, and the obtained proteins were analysed by BLAST to choose peptides specific for spp. from among the shared aligned sequences of related fungi. Read More

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November 2018
1 Read

Crescendo Transient Ischemic Attacks Due to Basilar Coccidioidal Meningitis With Coccidioma.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618813178. Epub 2018 Nov 19.

Kern Medical-UCLA, Bakersfield, CA, USA.

Coccidioidal meningitis typically presents with symptoms that may include headache, altered mental status including personality changes, fever, nausea, vomiting, gait abnormalities, and focal neurological deficits. This is a case of coccidioidal meningitis that initially presented as 4 consecutive crescendo cerebrovascular transient ischemic attacks with focal neurological deficits that resolved within minutes. Imaging showed a left basilar coccidioma. Read More

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November 2018
1 Read

Coccidioidomycosis: first cases reported in Pernambuco, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e75. Epub 2018 Nov 14.

Universidade Federal de Pernambuco, Departamento de Micologia, Recife, Pernambuco, Brazil.

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. Read More

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November 2018
3 Reads

The utility of real-time polymerase chain reaction in detecting Coccidioides immitis among clinical specimens in the Central California San Joaquin Valley.

Med Mycol 2018 Nov 21. Epub 2018 Nov 21.

University of California-San Francisco, Fresno, California, USA.

Coccidioidomycosis, the fungal infection caused by dimorphic Coccidioides species, is typically diagnosed by histopathologic identification of spherules, by culture, or by serology. These tests are reliable but time-intensive, delaying diagnosis and treatment. Rapid real-time polymerase chain reaction (RT-PCR) can be performed and was validated to identify Coccidioides immitis using an in-house developed assay for the Becton Dickinson molecular instrument (BD MAXTM). Read More

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November 2018
9 Reads

APX001 and Other Gwt1 inhibitor Prodrugs are Effective in Experimental Pneumonia.

Antimicrob Agents Chemother 2018 Nov 19. Epub 2018 Nov 19.

VA Healthcare, San Diego, CA

Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, , and that are endemic in the southwestern US and other areas in the Western Hemisphere. Chronic cavitary pulmonary infections and extra-pulmonary sites of infection are very difficult to treat and often require life-long azole therapy. APX001A is the first in a new class of broad spectrum antifungal agents which inhibit Gwt1, an enzyme which is required for localization of glycosylphosphatidyl inositol (GPI)-anchored mannoproteins in fungi. Read More

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November 2018
3 Reads

Complications and Management of a Rare Case of Disseminated Coccidioidomycosis to the Vertebral Spine.

Authors:
Sammy G Nakhla

Case Rep Infect Dis 2018 8;2018:8954016. Epub 2018 Oct 8.

Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA.

Coccidioidomycosis, also known as San Joaquin Valley Fever or Valley Fever, is mostly a pulmonary infection caused by inhalation of spores in an endemic region. Dissemination to bone, joints, meninges, and skin occurs less than one percent of the time. Skeletal involvement accounts for approximately half of the disseminated coccidioidomycosis with the vertebrae as the most common skeletal region. Read More

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October 2018
5 Reads

Gene exchange between two divergent species of the fungal human pathogen, Coccidioides.

Evolution 2018 Nov 9. Epub 2018 Nov 9.

Biology Department, University of North Carolina, Chapel Hill, North Carolina.

The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. Read More

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November 2018
1 Read
4.610 Impact Factor

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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October 2018
4 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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October 2018
1 Read

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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October 2018
7 Reads

Comparison of two FDA-cleared EIA assays for the detection of Coccidioides antibodies against a composite clinical standard.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Coccidioidomycosis is a disease endemic to the southwestern United States, parts of Mexico, and Central and South America. Diagnosis of the disease is commonly delayed because of the lack of prompt testing and the dearth of reliable diagnostic tests. Culture and nucleic acid testing require a specimen, yet the typical patient presents with a dry cough and no sputum. Read More

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October 2018
1 Read

Corticosteroids in the Management of Severe Coccidioidomycosis.

Am J Med 2018 Oct 2. Epub 2018 Oct 2.

Pulmonary, Critical Care and Sleep Section, Infectious Diseases Section, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Background: There is limited data suggesting that recovery from severe pulmonary infection with Coccidioides may be hastened by the addition of systemic corticosteroids.

Methods: We present a case report of 2 patients with persistent and progressive coccidioidomycosis who demonstrated a dramatic response to adjunctive corticosteroid therapy.

Results: Both patients had Coccidioides immitis cultured from respiratory samples. Read More

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October 2018
13 Reads

Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients.

AJNR Am J Neuroradiol 2018 Nov 4;39(11):2148-2153. Epub 2018 Oct 4.

Department of Radiology (J.R.), Mayo Clinic College of Medicine, Phoenix, Arizona.

Background And Purpose: is a dimorphic fungus endemic to the Southwest United States and Mexico, and at our institution, it is a relatively common pathogen presenting with a broad spectrum of associated spine diseases. We describe the various spinal manifestations resulting from coccidioidal infection and provide MR imaging examples from 41 pathologically proved cases.

Materials And Methods: Retrospective electronic medical record and PACS searches were performed. Read More

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November 2018
3 Reads

Investigating the Relationship Between Climate and Valley Fever (Coccidioidomycosis).

Ecohealth 2018 Dec 3;15(4):840-852. Epub 2018 Oct 3.

Virginia Polytechnic Institute and State University, 115 Major Williams Hall, Blacksburg, VA, 4061, USA.

Valley fever (coccidioidomycosis) is a disease caused by inhalation of spores from the soil-dwelling Coccidioides fungal species. The disease is endemic to semiarid areas in the western USA and parts of Central and South America. The region of interest for this study, Kern County, California, accounts for approximately 14% of the reported valley fever cases in the USA each year. Read More

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December 2018
2 Reads

A novel form of intracranial coccidioidomycosis is present in dogs and exhibits characteristic clinical and magnetic resonance imaging findings.

Vet Radiol Ultrasound 2018 Sep 27. Epub 2018 Sep 27.

Veterinary Neurological Center, Phoenix, Arizona, 85040.

The neurological examination findings, clinical pathology (including Coccidioides immitis IgG/IgM serology) and magnetic resonance imaging (MRI) findings in 13 dogs with a novel form of intracranial coccidioidomycosis are described in a retrospective case series, with long-term clinical resolution documented in 11/13 dogs (84.6% of cases) with oral fluconazole therapy. The medical records of the Veterinary Neurological Center in Phoenix, Arizona from the years 2000 to 2017 were utilized to search for dogs with appropriate inclusion criteria. Read More

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September 2018
1 Read

Coccidioidomycosis Complement Fixation Titer Trends in the Age of Antifungals.

J Clin Microbiol 2018 Dec 27;56(12). Epub 2018 Nov 27.

Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA

Coccidioidomycosis is associated with a broad spectrum of illness severity, ranging from asymptomatic or self-limited pulmonary infection to life-threatening manifestations of disseminated disease. Serologic studies before the widespread availability of antifungals established current understanding of serologic kinetics and dynamics. Chart histories and complement fixation (CF) titer trends were analyzed for 434 antifungal-treated coccidioidomycosis patients, who were classified by three infectious disease physicians as having either pulmonary uncomplicated coccidioidomycosis (PUC) ( = 248), pulmonary chronic coccidioidomycosis (PCC) ( = 64), disseminated coccidioidomycosis (DC) not including meningitis ( = 86), or coccidioidal meningitis (CM) ( = 36). Read More

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December 2018
1 Read

Occupational Coccidioidomycosis in a heavy equipment operator.

Authors:
Mark Nicas

J Occup Environ Hyg 2018 Sep 19:1-17. Epub 2018 Sep 19.

a University of California School of Public Health , 140 Warren Hall Berkeley California 94720.

This paper describes a case of Coccidioidomycosis pneumonia in an individual who worked in the McKittrick Oil Field, Kern County, California, for fifteen days during an approximate one-month period in 2016. Coccidioidomycosis is caused by inhaling spores of Coccidioides immitis, a soil fungus endemic in regions of California, most notably the San Joaquin Valley. In California, Kern County has the highest incidence rate of Coccidioidomycosis, and the McKittrick Oil Field lies within the most highly endemic part of Kern County. Read More

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September 2018
2 Reads

Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis.

Int J Dermatol 2018 Sep 19. Epub 2018 Sep 19.

Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ, USA.

Background: Fluconazole is the most commonly used antifungal treatment for various forms of coccidioidomycosis. Although we had anecdotally observed a high proportion of patients reporting cutaneous adverse effects associated with fluconazole treatment, this observation was not well described in the medical literature, and we were unsure of the additional effect of the arid desert environment of Arizona.

Methods: We performed a one-time, voluntary survey of patients with coccidioidomycosis and compared the responses of patients treated with fluconazole with those of untreated patients. Read More

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September 2018
2 Reads

Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico.

J Fungi (Basel) 2018 Sep 9;4(3). Epub 2018 Sep 9.

Medical Research Centre for Medical Mycology, Wellcome Trust Strategic Award, Institute of Medical Science, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.

In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016⁻2017 are described. A total of 55 individuals were included. Read More

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September 2018
3 Reads

Multiple Intracranial Aneurysms from Coccidioidal Meningitis: A Case Report Featuring Aneurysm Formation and Spontaneous Thrombosis with Literature Review.

World Neurosurg 2018 Sep 7. Epub 2018 Sep 7.

Department of Neurological Surgery,Keck School of Medicine,University of Southern California,Los Angeles,CA,USA.

Background: Coccidioidal meningitis can progress to vasculitis with aneurysm formation. Although aneurysmogenesis is rare, it carries exceptionally high mortality. Except in one instance, prior case reports have documented universally fatal consequences. Read More

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September 2018
1 Read

Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity.

Virulence 2018 ;9(1):1426-1435

a Division of Infectious Diseases, Department of Medicine , University of California San Diego School of Medicine , San Diego , CA , USA.

Coccidioides immitis and C. posadasii are two highly pathogenic dimorphic fungal species that are endemic in the arid areas of the new world, including the region from west Texas to southern and central California in the USA that cause coccidioidomycosis (also known as Valley Fever). In highly endemic regions such as southern Arizona, up to 50% of long term residents have been infected. Read More

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January 2018
14 Reads

Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.

Mycopathologia 2018 Oct 30;183(5):793-803. Epub 2018 Aug 30.

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. Read More

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October 2018
1 Read

Erythema Sweetobullosum: A Reactive Cutaneous Manifestation of Coccidioidomycosis.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618796659. Epub 2018 Aug 24.

Kern Medical Center, Bakersfield, CA, USA.

Reactive cutaneous coccidioidal skin manifestations are commonly noticed during the early stage of coccidioidomycosis. These skin lesions are devoid of any active coccidioidal organism, and the immune trigger mechanisms are not elucidated. We describe 6 cases of unusual reactive cutaneous coccidioidal manifestation, characterized by painful vesiculobullous lesions known as erythema sweetobullosum. Read More

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August 2018
1 Read

Endemic Mycoses in Solid Organ Transplant Recipients.

Infect Dis Clin North Am 2018 09;32(3):667-685

Division of Infectious Diseases, University of North Carolina, CB 7030, 130 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address:

The endemic mycoses are a group of thermally dimorphic fungal pathogens occupying a specific geographic range. In North America, the chief endemic mycoses are histoplasmosis, coccidioidomycosis, and blastomycosis. Endemic fungi can cause serious infections in solid organ transplant recipients from primary infection, reactivation of latent disease, or donor-derived infection. Read More

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September 2018
3 Reads

Coccidioidomycosis Outbreak Among Workers Constructing a Solar Power Farm - Monterey County, California, 2016-2017.

MMWR Morb Mortal Wkly Rep 2018 Aug 24;67(33):931-934. Epub 2018 Aug 24.

In January 2017, two local health departments notified the California Department of Public Health (CDPH) of three cases of coccidioidomycosis among workers constructing a solar power installation (solar farm) in southeastern Monterey County. Coccidioidomycosis, or Valley fever, is an infection caused by inhalation of the soil-dwelling fungus Coccidioides, which is endemic in the southwestern United States, including California. After a 1-3 week incubation period, coccidioidomycosis most often causes influenza-like symptoms or pneumonia, but rarely can lead to severe disseminated disease or death (1). Read More

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August 2018
10 Reads

Infectious diseases acquired by international travellers visiting the USA.

J Travel Med 2018 Aug;25(1)

Orlando Health Infectious Disease, University of Central Florida College of Medicine, Orlando, FL, USA.

Background: Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income countries is very frequent. Despite being a top international tourist destination, few sources describe the spectrum of infectious diseases acquired among travellers to the USA.

Methods: We performed a descriptive analysis summarizing demographic and travel characteristics, and clinical diagnoses among non-US-resident international travellers seen during or after travel to the USA at a GeoSentinel clinic from 1 January 1997 through 31 December 2016. Read More

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August 2018
12 Reads

Glucan-chitin particles enhance Th17 response and improve protective efficacy of a multivalent antigen (rCpa1) against pulmonary infection.

Infect Immun 2018 Aug 13. Epub 2018 Aug 13.

Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, TX 78249, USA.

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent, recombinant polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e. Read More

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August 2018
3 Reads

Risk Stratification With Coccidioidal Skin Test to Prevent Valley Fever Among Inmates, California, 2015.

J Correct Health Care 2018 Oct 13;24(4):342-351. Epub 2018 Aug 13.

1 Public Health Branch, California Correctional Health Care Services, Elk Grove, CA, USA.

Two California state prisons (A and B) have very high rates of coccidioidomycosis (Valley Fever). The prison health care service sought to improve their prevention strategy by risk stratification with a newly available spherulin-based Coccidioides delayed-type hypersensitivity test. Of the 36,789 voluntarily screened inmates, 4. Read More

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October 2018
10 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 Aug;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

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August 2018
9 Reads

Interlaboratory agreement of coccidioidomycosis enzyme immunoassay from two different manufacturers.

Med Mycol 2018 Jul 31. Epub 2018 Jul 31.

Maricopa County Department of Public Health, Phoenix, Arizona, USA.

Coccidioidomycosis, a fungal infection endemic to the Southwestern United States, is challenging to diagnose. The coccidioidomycosis enzyme immunoassay (EIA) test is the least expensive and simplest to perform to detect coccidioidomycosis antibodies in the serum. Concerns regarding falsely positive immunoglobulin (Ig) M EIA test results have led to questions about the agreement of commercially available EIA test kits among laboratories. Read More

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July 2018
2 Reads

The Utility of Screening for Coccidioidomycosis in Recipients of Inhibitors of Tumor Necrosis Factor-α.

Clin Infect Dis 2018 Aug 2. Epub 2018 Aug 2.

Division of Infectious Diseases, Mayo Clinic, Scottsdale, Arizona.

Background: Tumor necrosis factor-α inhibitors (TNFi) are commonly used to treat immune-mediated disorders, but they are associated with an increased risk of mycobacterial and fungal infections. We compared outcomes of TNFi recipients screened for asymptomatic coccidioidomycosis with those of unscreened patients to compare development of symptomatic coccidioidomycosis and to describe outcomes for patients with abnormal coccidioidal screening.

Methods: We searched electronic health records from September 4, 2010, through September 26, 2016, for all patients receiving a TNFi for dermatologic, rheumatologic, or gastroenterologic diagnoses and then categorized patients by whether or not they had undergone coccidioidal serologic testing for screening or diagnostic purposes. Read More

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August 2018
2 Reads

Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings.

Vet Pathol 2018 11 2;55(6):905-915. Epub 2018 Aug 2.

2 Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Coccidioidomycosis in nonhuman primates has been sporadically reported in the literature. This study describes 22 cases of coccidioidomycosis in nonhuman primates within an endemic region, and 79 cases of coccidioidomycosis from the veterinary literature are also reviewed. The 22 cases included baboons ( n = 10), macaques ( n = 9), and chimpanzees ( n = 3). Read More

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November 2018
4 Reads

Pleural coccidioidomycosis presenting as spontaneous pneumothorax.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Internal Medicine, Methodist Health System, Dallas, Texas, USA.

is a fungus endemic to Southwestern USA and Northern Mexico which can be asymptomatic or result in a well-defined clinical syndrome of community-acquired pneumonia. On rare occasion, coccidioidomycosis may have atypical presentations as in our patient, a 25-year-old man admitted with a 2-month history of progressive dyspnoea and cough. He was found to have a large right-sided pneumothorax with exudative pleural effusion which did not resolve following thoracentesis. Read More

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July 2018
12 Reads

Characterizing in vitro spherule morphogenesis of multiple strains of both species of Coccidioides.

Med Mycol 2018 Jul 20. Epub 2018 Jul 20.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona.

The disease San Joaquin Valley Fever (coccidioidomycosis) is caused by the inhalation of Coccidioides arthroconidia. In vivo, arthroconidia transform into pathogenic structures termed spherules. Exposure to the host milieu triggers spherule development; however, the molecular mechanisms responsible for the morphological shift are not well characterized. Read More

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July 2018
3 Reads
2.340 Impact Factor

Enhanced Surveillance for Coccidioidomycosis, 14 US States, 2016.

Emerg Infect Dis 2018 Jul;24(8):1444-1452

Although coccidioidomycosis in Arizona and California has been well-characterized, much remains unknown about its epidemiology in states where it is not highly endemic. We conducted enhanced surveillance in 14 such states in 2016 by identifying cases according to the Council of State and Territorial Epidemiologists case definition and interviewing patients about their demographic characteristics, clinical features, and exposures. Among 186 patients, median time from seeking healthcare to diagnosis was 38 days (range 1-1,654 days); 70% had another condition diagnosed before coccidioidomycosis testing occurred (of whom 83% were prescribed antibacterial medications); 43% were hospitalized; and 29% had culture-positive coccidioidomycosis. Read More

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July 2018
19 Reads

Disseminated coccidioidomycosis as a harbinger of climate change.

JAAD Case Rep 2018 Jun 30;4(5):424-425. Epub 2018 Apr 30.

The University of California San Francisco.

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June 2018
10 Reads

A case series of primary cutaneous coccidioidomycosis after a record-breaking rainy season.

JAAD Case Rep 2018 Jun 30;4(5):412-414. Epub 2018 Apr 30.

Department of Pathology, Kaiser Permanente Los Angeles, Los Angeles, California.

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June 2018
2 Reads

Safety and efficacy of chronic suppressive azole therapy for endemic fungal infections in solid organ transplant recipients.

Transpl Infect Dis 2018 Oct 20;20(5):e12963. Epub 2018 Jul 20.

Department of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Although the research is limited, treatment guidelines recommend lifelong suppressive azole therapy for disseminated endemic fungal infection (EFI) after solid organ transplantation (SOT). Suppressive azole therapy may prevent EFI recurrence at the risk of hepatotoxicity and drug interactions. We present real-world safety and effectiveness data of chronic suppressive azole therapy for EFI in SOT recipients over a 10-year period at a single comprehensive transplant center. Read More

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October 2018
10 Reads

Disseminated coccidioidomycosis.

Postgrad Med J 2018 Jul 3. Epub 2018 Jul 3.

Department of Infectious Diseases, Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota, USA.

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July 2018
4 Reads

Novel Treatment of Disseminated Coccidioidomycosis in a Dog with Voriconazole.

Case Rep Vet Med 2018 5;2018:1785748. Epub 2018 Apr 5.

Veterinary Emergency Service, 1612 N High Point Rd, No. 100, Middleton, WI 53562, USA.

A dog with disseminated coccidioidomycosis involving the vertebral, cutaneous, and pulmonary systems was treated successfully with voriconazole after failing traditional therapy with fluconazole and terbinafine. This report is the first to describe the successful management of refractory coccidioidomycosis with voriconazole in a dog. Read More

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Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018 28;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

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June 2018
24 Reads

The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis.

Antimicrob Agents Chemother 2018 Sep 27;62(9). Epub 2018 Aug 27.

University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Olorofim (formerly F901318) is an advanced analog of the orotomide class that inhibits fungal pyrimidine biosynthesis. We evaluated the and activities of olorofim against species. activity was assessed against 59 clinical isolates. Read More

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September 2018
2 Reads

High-throughput label-free microcontact printing graphene-based biosensor for valley fever.

Colloids Surf B Biointerfaces 2018 Oct 19;170:219-223. Epub 2018 Jun 19.

Bioengineering Program, School of Engineering, University of California-Merced, Merced, 95343, CA, USA. Electronic address:

The highly prevalent and virulent disease in the Western Hemisphere Coccidioidomycosis, also known as Valley Fever, can cause serious illness such as severe pneumonia with respiratory failure. It can also take on a disseminated form where the infection spreads throughout the body. Thus, a serious impetus exists to develop effective detection of the disease that can also operate in a rapid and high-throughput fashion. Read More

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October 2018
2 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
27 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
43 Reads

Unusual Presentations of Coccidioidomycosis in Conjunction With Autoimmune Syndromes: A Literature Review and Case Series.

J Clin Rheumatol 2018 Jun 15. Epub 2018 Jun 15.

Division of Rheumatology Department of Internal Medicine University of Arizona Tucson, AZ Department of Internal Medicine College of Medicine University of Arizona Tucson, AZ Department of Internal Medicine College of Medicine University of Arizona Tucson, AZ Division of Infectious Disease The Valley Fever Center for Excellence Department of Internal Medicine University of Arizona Tucson, AZ.

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June 2018
4 Reads

Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015.

Emerg Infect Dis 2018 Jul;24(7):1257-1266

Endemic mycoses represent a growing public health challenge in North America. We describe the epidemiology of 1,392 microbiology laboratory-confirmed cases of blastomycosis, histoplasmosis, and coccidioidomycosis in Ontario during 1990-2015. Blastomycosis was the most common infection (1,092 cases; incidence of 0. Read More

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July 2018
1 Read

Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis.

Br J Dermatol 2018 Jun;178(6):e394

Department of Dermatology, Peking University First Hospital, Beijing, China.

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June 2018
8 Reads