399 results match your criteria Coccidioidomycosis Infectious Diseases


Health Considerations for HIV-Infected International Travelers.

Curr Infect Dis Rep 2019 Apr 12;21(5):16. Epub 2019 Apr 12.

Harvard Medical School, Boston, MA, USA.

Purpose Of The Review: International travel continues to steadily increase, including leisure travel, travel to one's country of origin to visit friends and relatives, travel for service work, and business travel. Travelers with HIV may have an increased risk for travel-associated infections. The pre-travel medical consultation is an important means of assessing one's risk for travel-related health issues. Read More

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http://dx.doi.org/10.1007/s11908-019-0672-yDOI Listing
April 2019
6 Reads

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

Endemic fungal infections in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Mar 29:e13553. Epub 2019 Mar 29.

Department of Internal Medicine, University of Kansas School of Medicine Wichita, Wichita, Kansas.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of blastomycosis, histoplasmosis, and coccidioidomycosis in the pre- and post-transplant period. Though each of these endemic fungal infections has unique epidemiology and clinical manifestations, they all share a predilection for primary pulmonary infection and may cause disseminated infection, particularly in immunocompromised hosts. Culture remains the gold standard for definitive diagnosis, but more rapid diagnosis may be achieved with direct visualization of organisms from clinical specimens and antigen-based enzyme immunoassay assays. Read More

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http://dx.doi.org/10.1111/ctr.13553DOI Listing
March 2019
1 Read

[Climate change and systemic fungal infections].

Authors:
Volker Rickerts

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Mar 28. Epub 2019 Mar 28.

FG 16, Erreger von Mykosen, Mykobakteriosen und Parasitosen, Konsiliarlabor für Kryptokokkose und seltene Systemmykosen, Robert Koch-Institut, Seestraße 10, 13353, Berlin, Deutschland.

Background: Climate change may cause profound and complex changes in the prevalence of infectious diseases. Obligate pathogenic fungi causing endemic mycoses and the agents of cryptococcosis are environmental pathogens adapted to environmental niches. They may be exposed to changing climatic conditions, which may change the epidemiology of human infections. Read More

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http://dx.doi.org/10.1007/s00103-019-02931-zDOI Listing
March 2019
1 Read

De novo coccidioidomycosis among solid organ transplant recipients 1 or more years after transplant.

Am J Transplant 2019 Feb 27. Epub 2019 Feb 27.

Division of Infectious Diseases, Banner University Medical Center, University of Arizona, Tucson, Arizona.

Solid organ transplant recipients who contract coccidioidomycosis are at risk for complicated, protracted, disseminated, and severe disease. To date, no studies have described outcomes for patients who develop coccidioidomycosis only after the first posttransplant year. This study was a joint project of Mayo Clinic Hospital, Phoenix, Arizona, and the University of Arizona/Banner University Medical Center, Tucson, Arizona. Read More

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http://dx.doi.org/10.1111/ajt.15324DOI Listing
February 2019
2 Reads

Clinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004-2018.

J Feline Med Surg 2019 Feb 20:1098612X19829910. Epub 2019 Feb 20.

2 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA.

Objectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species.

Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, Arizona. Data collected included signalment, clinical signs, physical examination findings, diagnostic test results, treatment and outcome. Read More

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http://dx.doi.org/10.1177/1098612X19829910DOI Listing
February 2019
2 Reads

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
7 Reads

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S76-S84

Division of Infectious Diseases, UT Health San Antonio, and the South Texas Veterans Health Care System; San Antonio, Texas, USA.

Coccidioidomycosis remains a significant clinical problem with substantial morbidity and mortality. The vast majority of infections are asymptomatic and the need for early primary therapy remains controversial. The use of triazole antifungals has improved tolerability of therapy but concerns about acute and long-term toxicities among available agents limit their use. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S76/530
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http://dx.doi.org/10.1093/mmy/myy029DOI Listing
February 2019
20 Reads

Epidemiology of coccidioidomycosis among children in California, 2000-2016.

Med Mycol 2019 Feb;57(Supplement_1):S64-S66

Infectious Diseases Branch, California Department of Public Health, Richmond, California.

We calculated population-based incidence of coccidioidomycosis from the 2000-2016 California surveillance data and compared children (≤17 years) with adults (≥18 years). During that time, the annual pediatric incidence per 100,000 increased from 0.8 in 2000 to 5. Read More

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http://dx.doi.org/10.1093/mmy/myy066DOI Listing
February 2019
5 Reads

Occupational coccidioidomycosis surveillance and recent outbreaks in California.

Med Mycol 2019 Feb;57(Supplement_1):S41-S45

United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.

Workers in Coccidioides-endemic areas performing soil-disturbing work or exposed to windy and dusty conditions are at increased risk for coccidioidomycosis. Four occupational coccidioidomycosis outbreaks from 2007 to 2014 in California are described, involving construction workers in a number of excavation projects and an outdoor filming event involving cast and crew. These outbreaks highlight the importance of identifying industries and occupations at high risk for coccidioidomycosis, conducting targeted occupational health surveillance to assess the burden of illness, developing and implementing prevention strategies, and setting research priorities. Read More

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http://dx.doi.org/10.1093/mmy/myy031DOI Listing
February 2019
5 Reads

Patient With a 42-Year History of Coccidioidal Meningitis.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820047. Epub 2018 Dec 20.

Kern Medical-UCLA, Bakersfield, CA, USA.

This is a case of a 56-year-old man diagnosed with coccidioidal meningitis 42 years ago at the age of 14. He was treated with intrathecal amphotericin B deoxycholate by cisternal puncture for 15 years before switching to fluconazole once it became available in 1991. Over 42 years of treatment, he developed hearing loss due to auditory nerve neurotoxicity, hydrocephalus requiring ventriculoperitoneal shunting with associated malfunctions, lumbar arachnoiditis, and hypokalemic paralysis. Read More

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http://dx.doi.org/10.1177/2324709618820047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302271PMC
December 2018
8 Reads

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2019 Mar 1;62(3):268-273. Epub 2019 Jan 1.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380936PMC
March 2019
8 Reads

Tolerability of long-term fluconazole therapy.

J Antimicrob Chemother 2019 Mar;74(3):768-771

Department of Medical Microbiology and Immunology, University of California, Med Science Dr., Davis, CA, USA.

Background: Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require lifelong treatment. Read More

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http://dx.doi.org/10.1093/jac/dky501DOI Listing
March 2019
8 Reads

Coccidioidomycosis in alpacas in the southwestern United States.

Transbound Emerg Dis 2019 Mar 14;66(2):807-812. Epub 2018 Dec 14.

Valley Fever Center for Excellence, The University of Arizona, Tucson, Arizona.

An anonymous web-based survey of alpaca owners was used to learn more about the clinical presentation, diagnosis, and treatment of coccidioidomycosis in alpacas in the United States. Thirty-seven owners, with 1,117 alpacas, completed the survey. Over 4% of alpacas included in the study were diagnosed with coccidioidomycosis between 2005 and 2016 (5 post mortem, 46 clinically). Read More

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http://dx.doi.org/10.1111/tbed.13088DOI Listing
March 2019
5 Reads

Coccidioidomycosis: first cases reported in Pernambuco, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e75. Epub 2018 Nov 14.

Universidade Federal de Pernambuco, Departamento de Micologia, Recife, Pernambuco, Brazil.

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. Read More

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http://dx.doi.org/10.1590/S1678-9946201860075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235429PMC
November 2018
14 Reads

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Pneumonia.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

VA Healthcare, San Diego, California, USA

Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, and , that are endemic in the southwestern United States and other areas in the Western Hemisphere. Chronic cavitary pulmonary infections and extrapulmonary sites of infection are very difficult to treat and often require lifelong azole therapy. APX001A is the first in a new class of broad-spectrum antifungal agents that inhibit Gwt1, an enzyme which is required for cell wall localization of glycosylphosphatidylinositol (GPI)-anchored mannoproteins in fungi. Read More

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http://dx.doi.org/10.1128/AAC.01715-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355600PMC
February 2019
28 Reads

Gene exchange between two divergent species of the fungal human pathogen, Coccidioides.

Evolution 2019 Jan 4;73(1):42-58. Epub 2018 Dec 4.

Biology Department, University of North Carolina, Chapel Hill, North Carolina.

The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. Read More

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http://dx.doi.org/10.1111/evo.13643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430640PMC
January 2019
6 Reads
4.612 Impact Factor

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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http://www.kcdcphrp.org/journal/view.html?doi=10.24171/j.phr
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http://dx.doi.org/10.24171/j.phrp.2018.9.5.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202016PMC
October 2018
18 Reads

Comparison of two FDA-cleared EIA assays for the detection of Coccidioides antibodies against a composite clinical standard.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Coccidioidomycosis is a disease endemic to the southwestern United States, parts of Mexico, and Central and South America. Diagnosis of the disease is commonly delayed because of the lack of prompt testing and the dearth of reliable diagnostic tests. Culture and nucleic acid testing require a specimen, yet the typical patient presents with a dry cough and no sputum. Read More

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http://dx.doi.org/10.1093/mmy/myy094DOI Listing
October 2018
7 Reads

Corticosteroids in the Management of Severe Coccidioidomycosis.

Am J Med 2019 Jan 2;132(1):110-113. Epub 2018 Oct 2.

Pulmonary, Critical Care and Sleep Section, Infectious Diseases Section, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Background: There is limited data suggesting that recovery from severe pulmonary infection with Coccidioides may be hastened by the addition of systemic corticosteroids.

Methods: We present a case report of 2 patients with persistent and progressive coccidioidomycosis who demonstrated a dramatic response to adjunctive corticosteroid therapy.

Results: Both patients had Coccidioides immitis cultured from respiratory samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183094
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http://dx.doi.org/10.1016/j.amjmed.2018.09.020DOI Listing
January 2019
20 Reads

Coccidioidomycosis Complement Fixation Titer Trends in the Age of Antifungals.

J Clin Microbiol 2018 Dec 27;56(12). Epub 2018 Nov 27.

Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA

Coccidioidomycosis is associated with a broad spectrum of illness severity, ranging from asymptomatic or self-limited pulmonary infection to life-threatening manifestations of disseminated disease. Serologic studies before the widespread availability of antifungals established current understanding of serologic kinetics and dynamics. Chart histories and complement fixation (CF) titer trends were analyzed for 434 antifungal-treated coccidioidomycosis patients, who were classified by three infectious disease physicians as having either pulmonary uncomplicated coccidioidomycosis (PUC) ( = 248), pulmonary chronic coccidioidomycosis (PCC) ( = 64), disseminated coccidioidomycosis (DC) not including meningitis ( = 86), or coccidioidal meningitis (CM) ( = 36). Read More

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http://dx.doi.org/10.1128/JCM.01318-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258849PMC
December 2018
4 Reads

Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis.

Int J Dermatol 2019 Feb 19;58(2):250-253. Epub 2018 Sep 19.

Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ, USA.

Background: Fluconazole is the most commonly used antifungal treatment for various forms of coccidioidomycosis. Although we had anecdotally observed a high proportion of patients reporting cutaneous adverse effects associated with fluconazole treatment, this observation was not well described in the medical literature, and we were unsure of the additional effect of the arid desert environment of Arizona.

Methods: We performed a one-time, voluntary survey of patients with coccidioidomycosis and compared the responses of patients treated with fluconazole with those of untreated patients. Read More

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http://dx.doi.org/10.1111/ijd.14238DOI Listing
February 2019
5 Reads

Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico.

J Fungi (Basel) 2018 Sep 9;4(3). Epub 2018 Sep 9.

Medical Research Centre for Medical Mycology, Wellcome Trust Strategic Award, Institute of Medical Science, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.

In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016⁻2017 are described. A total of 55 individuals were included. Read More

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http://www.mdpi.com/2309-608X/4/3/109
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http://dx.doi.org/10.3390/jof4030109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162685PMC
September 2018
12 Reads

Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity.

Virulence 2018 ;9(1):1426-1435

a Division of Infectious Diseases, Department of Medicine , University of California San Diego School of Medicine , San Diego , CA , USA.

Coccidioides immitis and C. posadasii are two highly pathogenic dimorphic fungal species that are endemic in the arid areas of the new world, including the region from west Texas to southern and central California in the USA that cause coccidioidomycosis (also known as Valley Fever). In highly endemic regions such as southern Arizona, up to 50% of long term residents have been infected. Read More

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https://www.tandfonline.com/doi/full/10.1080/21505594.2018.1
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http://dx.doi.org/10.1080/21505594.2018.1509667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141143PMC
April 2019
17 Reads

Endemic Mycoses in Solid Organ Transplant Recipients.

Infect Dis Clin North Am 2018 09;32(3):667-685

Division of Infectious Diseases, University of North Carolina, CB 7030, 130 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address:

The endemic mycoses are a group of thermally dimorphic fungal pathogens occupying a specific geographic range. In North America, the chief endemic mycoses are histoplasmosis, coccidioidomycosis, and blastomycosis. Endemic fungi can cause serious infections in solid organ transplant recipients from primary infection, reactivation of latent disease, or donor-derived infection. Read More

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http://dx.doi.org/10.1016/j.idc.2018.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230265PMC
September 2018
10 Reads

Infectious diseases acquired by international travellers visiting the USA.

J Travel Med 2018 08;25(1)

Orlando Health Infectious Disease, University of Central Florida College of Medicine, Orlando, FL, USA.

Background: Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income countries is very frequent. Despite being a top international tourist destination, few sources describe the spectrum of infectious diseases acquired among travellers to the USA.

Methods: We performed a descriptive analysis summarizing demographic and travel characteristics, and clinical diagnoses among non-US-resident international travellers seen during or after travel to the USA at a GeoSentinel clinic from 1 January 1997 through 31 December 2016. Read More

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https://academic.oup.com/jtm/article/doi/10.1093/jtm/tay053/
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http://dx.doi.org/10.1093/jtm/tay053DOI Listing
August 2018
28 Reads

Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection.

Infect Immun 2018 11 25;86(11). Epub 2018 Oct 25.

Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA.

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e. Read More

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http://dx.doi.org/10.1128/IAI.00070-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204714PMC
November 2018
12 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 08;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

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https://academic.oup.com/jtm/article/doi/10.1093/jtm/tay055/
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http://dx.doi.org/10.1093/jtm/tay055DOI Listing
August 2018
19 Reads

The Utility of Screening for Coccidioidomycosis in Recipients of Inhibitors of Tumor Necrosis Factor α.

Clin Infect Dis 2019 Mar;68(6):1024-1030

Division of Infectious Diseases, Mayo Clinic, Scottsdale, Arizona.

Background: Tumor necrosis factor α inhibitors (TNFi) are commonly used to treat immune-mediated disorders, but they are associated with an increased risk of mycobacterial and fungal infections. We compared the outcomes of TNFi recipients screened for asymptomatic coccidioidomycosis with those of unscreened patients to compare the development of symptomatic coccidioidomycosis and to describe its outcomes for patients with abnormal coccidioidal screenings.

Methods: We searched electronic health records from 4 September 2010 through 26 September 2016 for all patients receiving a TNFi for dermatologic, rheumatologic, or gastroenterologic diagnoses, then categorized patients by whether or not they had undergone coccidioidal serologic testing for screening or diagnostic purposes. Read More

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http://dx.doi.org/10.1093/cid/ciy620DOI Listing
March 2019
6 Reads

Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings.

Vet Pathol 2018 11 2;55(6):905-915. Epub 2018 Aug 2.

2 Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Coccidioidomycosis in nonhuman primates has been sporadically reported in the literature. This study describes 22 cases of coccidioidomycosis in nonhuman primates within an endemic region, and 79 cases of coccidioidomycosis from the veterinary literature are also reviewed. The 22 cases included baboons ( n = 10), macaques ( n = 9), and chimpanzees ( n = 3). Read More

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http://dx.doi.org/10.1177/0300985818787306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385601PMC
November 2018
8 Reads

Pleural coccidioidomycosis presenting as spontaneous pneumothorax.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Internal Medicine, Methodist Health System, Dallas, Texas, USA.

is a fungus endemic to Southwestern USA and Northern Mexico which can be asymptomatic or result in a well-defined clinical syndrome of community-acquired pneumonia. On rare occasion, coccidioidomycosis may have atypical presentations as in our patient, a 25-year-old man admitted with a 2-month history of progressive dyspnoea and cough. He was found to have a large right-sided pneumothorax with exudative pleural effusion which did not resolve following thoracentesis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22585
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http://dx.doi.org/10.1136/bcr-2018-225854DOI Listing
July 2018
23 Reads

Enhanced Surveillance for Coccidioidomycosis, 14 US States, 2016.

Emerg Infect Dis 2018 07;24(8):1444-1452

Although coccidioidomycosis in Arizona and California has been well-characterized, much remains unknown about its epidemiology in states where it is not highly endemic. We conducted enhanced surveillance in 14 such states in 2016 by identifying cases according to the Council of State and Territorial Epidemiologists case definition and interviewing patients about their demographic characteristics, clinical features, and exposures. Among 186 patients, median time from seeking healthcare to diagnosis was 38 days (range 1-1,654 days); 70% had another condition diagnosed before coccidioidomycosis testing occurred (of whom 83% were prescribed antibacterial medications); 43% were hospitalized; and 29% had culture-positive coccidioidomycosis. Read More

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http://wwwnc.cdc.gov/eid/article/24/8/17-1595_article.htm
Publisher Site
http://dx.doi.org/10.3201/eid2408.171595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056093PMC
July 2018
37 Reads

Safety and efficacy of chronic suppressive azole therapy for endemic fungal infections in solid organ transplant recipients.

Transpl Infect Dis 2018 Oct 20;20(5):e12963. Epub 2018 Jul 20.

Department of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Although the research is limited, treatment guidelines recommend lifelong suppressive azole therapy for disseminated endemic fungal infection (EFI) after solid organ transplantation (SOT). Suppressive azole therapy may prevent EFI recurrence at the risk of hepatotoxicity and drug interactions. We present real-world safety and effectiveness data of chronic suppressive azole therapy for EFI in SOT recipients over a 10-year period at a single comprehensive transplant center. Read More

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http://dx.doi.org/10.1111/tid.12963DOI Listing
October 2018
14 Reads

Disseminated coccidioidomycosis.

Postgrad Med J 2018 Dec 3;94(1118):722-723. Epub 2018 Jul 3.

Department of Infectious Diseases, Minneapolis VA Health Care System, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1136/postgradmedj-2017-135545DOI Listing
December 2018
6 Reads

Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018 28;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

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https://www.karger.com/Article/FullText/489501
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http://dx.doi.org/10.1159/000489501DOI Listing
June 2018
27 Reads

Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis.

Case Rep Med 2018 16;2018:2723489. Epub 2018 Apr 16.

Division of Infectious Diseases, University of Colorado, Denver, CO, USA.

Miliary histoplasmosis is a rare presentation that may mimic miliary tuberculosis. We report a case of miliary histoplasmosis in a 52-year-old male who was being treated with hydroxychloroquine, methotrexate, and sulfasalazine for his rheumatoid arthritis and presented to the emergency department with shortness of breath and fevers. Computed tomography (CT) chest revealed miliary pulmonary nodules. Read More

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http://dx.doi.org/10.1155/2018/2723489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926488PMC
April 2018
6 Reads

Screening Coccidioides serology in kidney transplant recipients: A 10-year cross-sectional analysis.

Transpl Infect Dis 2018 Oct 26;20(5):e12932. Epub 2018 Jul 26.

Department of Medicine, Division of Nephrology, Kidney and Pancreas Transplant Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Background: Kidney transplant recipients (KTRs) are at risk for reactivation and complicated infection due to Coccidioides. Pre-transplant serological screening should provide benefit for patients from endemic areas. We evaluated Coccidioides seroprevalence by area of residence in KTRs at a major transplant program in Los Angeles. Read More

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http://dx.doi.org/10.1111/tid.12932DOI Listing
October 2018
5 Reads

Disseminated coccidioidomycosis masquerading as recurrent lymphoma.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Medicine and Cancer Center, University of Arizona College of Medicine, Tucson, Arizona, USA.

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http://dx.doi.org/10.1136/bcr-2018-224965DOI Listing
May 2018
8 Reads

Cytokine Release, Determined by a Multiplex Cytokine Assay, in Response to Coccidioidal Antigen Stimulation of Whole Blood among Subjects with Recently Diagnosed Primary Pulmonary Coccidioidomycosis.

mSphere 2018 May-Jun;3(3). Epub 2018 May 16.

Department of Microbiology and Immunology, University of California at Davis, Davis, California, USA.

The elements of the cellular immune response in human coccidioidomycosis remain undefined. We examined the release of an array of inflammatory proteins in response to incubation with a coccidioidal antigen preparation to ascertain which of these might be associated with diagnosis and outcome. Patients with a recent diagnosis of primary pulmonary coccidioidomycosis and a control group of healthy subjects were studied. Read More

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http://dx.doi.org/10.1128/mSphere.00065-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956148PMC
October 2018
9 Reads

Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.

Vaccine 2018 05 30;36(23):3375-3380. Epub 2018 Apr 30.

Valley Fever Center for Excellence, The University of Arizona, 1656 E Mabel St, PO Box 245215, Tucson, AZ 85724, United States; Division of Infectious Diseases, Department of Medicine, PO Box 245039, The University of Arizona, Tucson, AZ 85724, United States.

Coccidioidomycosis is a systemic fungal infection for which a vaccine has been sought for over fifty years. The avirulent Coccidioides posadasii strain, Δcps1, which is missing a 6 kb gene, showed significant protection in mice. These studies explore conditions of protection in mice and elucidate the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183050
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http://dx.doi.org/10.1016/j.vaccine.2018.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139032PMC
May 2018
6 Reads

Burden of Serious Fungal Infections in Argentina.

J Fungi (Basel) 2018 Apr 24;4(2). Epub 2018 Apr 24.

The Natonal Aspergillosis Centre, Wythenshawe Hospital, Manchester Academic Health Science Centre, and The University of Manchester, Manchester M23 9LT, UK.

The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Read More

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http://dx.doi.org/10.3390/jof4020051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023532PMC
April 2018
6 Reads

Evaluation of Amphotericin B Lipid Formulations for Treatment of Severe Coccidioidomycosis.

Antimicrob Agents Chemother 2018 Jul 26;62(7). Epub 2018 Jun 26.

Department of Infectious Diseases, Kern Medical/UCLA, Bakersfield, California, USA

Patients with severe coccidioidomycosis infections are often treated with either amphotericin B lipid complex (ABLC) or liposomal amphotericin B (L-AmB). Outcome data with these agents in severe coccidioidomycosis cases are currently lacking. The purpose of this study is to evaluate the efficacy and toxicity of ABLC and L-AmB in treating severe coccidioidomycosis. Read More

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http://dx.doi.org/10.1128/AAC.02293-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021679PMC
July 2018
9 Reads

Top Questions in the Diagnosis and Treatment of Coccidioidomycosis.

Open Forum Infect Dis 2017 12;4(4):ofx197. Epub 2017 Sep 12.

The Valley Fever Center for Excellence and Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona.

Revised and greatly expanded treatment guidelines for coccidioidomycosis were published last year by the Infectious Diseases Society of America. We have selected 4 questions that commonly arise in the management of patients suspected of this disease and for which there remain divided opinions. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofx19
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http://dx.doi.org/10.1093/ofid/ofx197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903411PMC
September 2017
18 Reads

Coccidioidomycosis in selected immunosuppressed hosts.

Med Mycol 2019 Feb;57(Supplement_1):S56-S63

Division of Infectious Diseases, Sanford Health, Sioux Falls, South Dakota, USA.

After contracting coccidioidomycosis, persons with impaired cellular immunity are more likely than healthy persons to have severe infection, disseminated infection, and higher mortality rates. In this brief review, we summarize the clinical manifestations, diagnosis, treatment, and prevention of coccidioidomycosis in persons infected with human immunodeficiency virus (HIV), recipients of solid organ or hematopoietic stem cell transplants, and recipients of biologic response modifiers. Among individuals infected with HIV, a diagnosis of acquired immunodeficiency syndrome (AIDS) and a CD4 T-lymphocyte count <250 cells/μl were associated with more severe coccidioidomycosis, whereas less severe disease occurred among those with undetectable HIV-RNA and higher CD4 T-lymphocyte counts, indicating that controlled HIV viremia and improved cellular immune status are important in limiting disease. Read More

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http://dx.doi.org/10.1093/mmy/myy019DOI Listing
February 2019
5 Reads

Pediatric Coccidioidomycosis: Case Series From a California Pediatric Infectious Diseases Clinic.

Pediatr Infect Dis J 2019 Feb;38(2):115-121

From the Infectious Diseases Branch, California Department of Public Health, Richmond, California.

Background: Coccidioidomycosis is not as well described in the pediatric population as it is in the adult population. We describe clinical findings, diagnosis and management of coccidioidomycosis in 108 pediatric patients seen in an outpatient clinic in the California Central Valley, an area endemic for coccidioidomycosis.

Methods: We reviewed medical records of a convenience sample of pediatric patients (≤17 years of age) diagnosed with coccidioidomycosis who visited an infectious diseases clinic in Madera, CA, during January 1 to October 1, 2012. Read More

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http://dx.doi.org/10.1097/INF.0000000000002069DOI Listing
February 2019
21 Reads

Prolonged voriconazole treatment in a patient with chronic lymphocytic leukemia resulting in a litany of chronic overlapping toxicities.

J Oncol Pharm Pract 2019 Apr 19;25(3):747-753. Epub 2018 Mar 19.

2 Department of Infectious Diseases Infection Control and Employee Heath, MD Anderson Cancer Center, The University of Texas Houston, TX, USA.

Voriconazole is a triazole antifungal with activity against a number of yeast and mold species including Candida, Aspergillosis, Fusarium, and Coccidioides. Invasive fungal infections are associated with high morbidity and mortality, prolonged treatment courses, and occasionally lifelong suppressive therapy. Voriconazole therapy can result in a number of acute toxicities that clinicians are frequently aware of including hepatotoxicity, visual disturbances, and hallucinations; however, there is limited experience with extended durations of voriconazole therapy. Read More

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http://dx.doi.org/10.1177/1078155218762624DOI Listing
April 2019
5 Reads

Coccidioides immitis septic knee arthritis.

BMJ Case Rep 2018 Mar 13;2018. Epub 2018 Mar 13.

Department of Medicine, New York University School of Medicine, New York, USA.

A 78-year-old man developed right knee pain and swelling without other systemic symptoms. He had travelled frequently to the Central Valley of California. He was diagnosed with coccidioidomycosis based on joint fluid culture. Read More

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http://dx.doi.org/10.1136/bcr-2017-222585DOI Listing
March 2018
8 Reads

Imported endemic mycoses in Spain: Evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997-2014.

PLoS Negl Trop Dis 2018 02 15;12(2):e0006245. Epub 2018 Feb 15.

Tropical Medicine Unit, Infectious Diseases Department. PROSICS Barcelona (International Health Program of the Catalan Health Institute), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to migration and temporary movements. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831632PMC
February 2018
8 Reads

Lung health in era of climate change and dust storms.

Environ Res 2018 05 6;163:36-42. Epub 2018 Feb 6.

Division of Pulmonary and Critical Care, University of Miami, Miami, FL, United States; Miami VA Healthcare System, Miami, FL, United States. Electronic address:

Dust storms are strong winds which lead to particle exposure over extensive areas. These storms influence air quality on both a local and global scale which lead to both short and long-term effects. The frequency of dust storms has been on the rise during the last decade. Read More

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http://dx.doi.org/10.1016/j.envres.2018.02.001DOI Listing
May 2018
12 Reads
4.370 Impact Factor

Coccidioidomycosis: Imported and possible domestic cases in China: A case report and review, 1958-2017.

Mycoses 2018 Jul 19;61(7):506-513. Epub 2018 Feb 19.

Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

We report a case of imported pulmonary coccidioidomycosis caused by Coccidioides posadasii in a patient who was misdiagnosed as tuberculosis and mistreated with antituberculosis medications for 18 months. The symptoms were not relieved until antifungal treatment was started. An extensive review of the coccidioidomycosis cases occurring in China reveals 38 cases, 16 of which had no associated history of travel to any traditional endemic areas. Read More

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http://dx.doi.org/10.1111/myc.12750DOI Listing
July 2018
11 Reads