3,361 results match your criteria Coccidioidomycosis


Clinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004-2018.

J Feline Med Surg 2019 Feb 20:1098612X19829910. Epub 2019 Feb 20.

2 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA.

Objectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species.

Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, Arizona. Data collected included signalment, clinical signs, physical examination findings, diagnostic test results, treatment and outcome. Read More

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http://dx.doi.org/10.1177/1098612X19829910DOI Listing
February 2019

Coccidioidal Meningitis in New York traced to Texas by Fungal Genomic Analysis.

Clin Infect Dis 2019 Feb 1. Epub 2019 Feb 1.

Valley Fever Center for Excellence and Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson Arizona.

A child developed hydrocephalus. Sixteen months later, it was discovered to be a complication of coccidioidal meningitis. The infection's source was uncertain until genomic analysis of the fungal isolate identified its origin to be a visit to Beeville Texas. Read More

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http://dx.doi.org/10.1093/cid/ciz052DOI Listing
February 2019
1 Read
8.886 Impact Factor

Coccidioidomycosis: What a long strange trip it's been.

Med Mycol 2019 Feb;57(Supplement_1):S3-S15

California Institute for Medical Research, San Jose, California, USA.

The recorded history of coccidioidomycosis began in 1892 with the report of the illness of Domingo Escurra by Alejandro Posadas followed by a description of the first North American cases by Rixford and Gilchrist. Originally considered a protozoan, William Ophüls determined that Coccidioides was a fungus and that the lungs were the apparent initial site of infection. During the 1930s, both Gifford and Dickson determined that a self-limited illness, Valley Fever, was caused by the same fungus that caused the often fatal coccidioidal granuloma. Read More

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http://dx.doi.org/10.1093/mmy/myy123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347081PMC
February 2019
2 Reads

The 7th International Coccidioidomycosis Symposium.

Authors:

Med Mycol 2019 Feb;57(Supplement_1):S1-S2

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http://dx.doi.org/10.1093/mmy/myy152DOI Listing
February 2019
1 Read

The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species.

Med Mycol 2019 Feb;57(Supplement_1):S16-S20

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.

The prevailing hypothesis concerning the ecology of Coccidioides immitis and C. posadasii is that these human pathogenic fungi are soil fungi endemic to hot, dry, salty regions of the New World and that humans and the local, small-mammal fauna are only accidental hosts. Here we advance an alternative hypothesis that Coccidioides spp. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S16/530
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http://dx.doi.org/10.1093/mmy/myy039DOI Listing
February 2019
4 Reads
2.335 Impact Factor

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
3 Reads

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S76-S84

Division of Infectious Diseases, UT Health San Antonio, and the South Texas Veterans Health Care System; San Antonio, Texas, USA.

Coccidioidomycosis remains a significant clinical problem with substantial morbidity and mortality. The vast majority of infections are asymptomatic and the need for early primary therapy remains controversial. The use of triazole antifungals has improved tolerability of therapy but concerns about acute and long-term toxicities among available agents limit their use. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S76/530
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http://dx.doi.org/10.1093/mmy/myy029DOI Listing
February 2019
6 Reads

Selected Clinical Features of Coccidioidomycosis in Dogs.

Med Mycol 2019 Feb;57(Supplement_1):S67-S75

School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Canine coccidioidomycosis, a systemic fungal infection endemic to arid and semiarid regions of North, Central, and South America, is commonly diagnosed in dogs living in or traveling through lower Sonoran life zones in the states of California and Arizona. Canine and human cases have geographic overlap. Similarities between clinical coccidioidomycosis in dogs and humans include asymptomatic infection, primary respiratory disease and disseminated disease. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S67/530
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http://dx.doi.org/10.1093/mmy/myy113DOI Listing
February 2019
6 Reads

Update on the Epidemiology of coccidioidomycosis in the United States.

Med Mycol 2019 Feb;57(Supplement_1):S30-S40

Maricopa County Department of Public Health, Phoenix, Arizona, USA.

The incidence of reported coccidioidomycosis in the past two decades has increased greatly; monitoring its changing epidemiology is essential for understanding its burden on patients and the healthcare system and for identifying opportunities for prevention and education. We provide an update on recent coccidioidomycosis trends and public health efforts nationally and in Arizona, California, and Washington State. In Arizona, enhanced surveillance shows that coccidioidomycosis continues to be associated with substantial morbidity. Read More

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http://dx.doi.org/10.1093/mmy/myy095DOI Listing
February 2019
1 Read

Epidemiology of coccidioidomycosis among children in California, 2000-2016.

Med Mycol 2019 Feb;57(Supplement_1):S64-S66

Infectious Diseases Branch, California Department of Public Health, Richmond, California.

We calculated population-based incidence of coccidioidomycosis from the 2000-2016 California surveillance data and compared children (≤17 years) with adults (≥18 years). During that time, the annual pediatric incidence per 100,000 increased from 0.8 in 2000 to 5. Read More

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http://dx.doi.org/10.1093/mmy/myy066DOI Listing
February 2019
2 Reads

Coccidioidomycosis in Latin America.

Med Mycol 2019 Feb;57(Supplement_1):S46-S55

CIPTIR, Hospital Universitario de Monterrey UANL, Mexico.

Coccidioidomycosis is a highly prevalent systemic mycosis in Latin America and has been reported (human and zoonotic cases) in México, Guatemala, Honduras, Colombia, Venezuela, Brazil, Paraguay, Bolivia, and Argentina. The incidence of coccidioidomycosis in Latin America is unknown due to lack of clinical awareness and limited access to laboratory diagnosis. Coccidioidomycosis is as prevalent in Mexico as in the endemic regions of the United States. Read More

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http://dx.doi.org/10.1093/mmy/myy037DOI Listing
February 2019
1 Read

Occupational coccidioidomycosis surveillance and recent outbreaks in California.

Med Mycol 2019 Feb;57(Supplement_1):S41-S45

United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.

Workers in Coccidioides-endemic areas performing soil-disturbing work or exposed to windy and dusty conditions are at increased risk for coccidioidomycosis. Four occupational coccidioidomycosis outbreaks from 2007 to 2014 in California are described, involving construction workers in a number of excavation projects and an outdoor filming event involving cast and crew. These outbreaks highlight the importance of identifying industries and occupations at high risk for coccidioidomycosis, conducting targeted occupational health surveillance to assess the burden of illness, developing and implementing prevention strategies, and setting research priorities. Read More

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http://dx.doi.org/10.1093/mmy/myy031DOI Listing
February 2019
2 Reads

Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen .

Microorganisms 2019 Jan 24;7(2). Epub 2019 Jan 24.

Monterey County Health Department, 1270 Natividad, Salinas, CA 93906, USA.

The incidence of coccidioidomycosis, also known as Valley Fever, is increasing in the Southwestern United States and Mexico. Despite considerable efforts, a vaccine to protect humans from this disease is not forthcoming. The aim of this project was to isolate and phylogenetically compare bacterial species that could serve as biocontrol candidates to suppress the growth of , the causative agent of coccidioidomycosis, in eroded soils or in areas close to human settlements that are being developed. Read More

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http://dx.doi.org/10.3390/microorganisms7020031DOI Listing
January 2019
3 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
1 Read

Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

MiraVista Diagnostics LLC. Indianapolis, Indiana, USA.

The diagnosis of coccidioidomycosis (CM) in dogs is typically based on clinical presentation, serology, and (less frequently) spherule identification. Agar gel immunodiffusion (AGID) is the most commonly employed serological method, but AGID is slow (requiring up to a week for titer). A Coccidioides antigen enzyme immunoassay (EIA) is also available; however, sensitivity is low in CM dogs. Read More

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http://dx.doi.org/10.1093/mmy/myy157DOI Listing
January 2019
1 Read

Patient With a 42-Year History of Coccidioidal Meningitis.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820047. Epub 2018 Dec 20.

Kern Medical-UCLA, Bakersfield, CA, USA.

This is a case of a 56-year-old man diagnosed with coccidioidal meningitis 42 years ago at the age of 14. He was treated with intrathecal amphotericin B deoxycholate by cisternal puncture for 15 years before switching to fluconazole once it became available in 1991. Over 42 years of treatment, he developed hearing loss due to auditory nerve neurotoxicity, hydrocephalus requiring ventriculoperitoneal shunting with associated malfunctions, lumbar arachnoiditis, and hypokalemic paralysis. Read More

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http://dx.doi.org/10.1177/2324709618820047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302271PMC
December 2018
2 Reads

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2019 Mar 1;62(3):268-273. Epub 2019 Jan 1.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380936PMC
March 2019
4 Reads

Autochthonous Transmission of Coccidioides in Animals, Washington, USA.

Emerg Infect Dis 2019 Jan;25(1):123-125

We report 5 cases of coccidioidomycosis in animals that were acquired within Washington, USA, and provide further evidence for the environmental endemicity of Coccidioides immitis within the state. Veterinarians should consider coccidioidomycosis in animals with compatible clinical signs that reside in, or have traveled to, south central Washington. Read More

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http://dx.doi.org/10.3201/eid2501.180411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302573PMC
January 2019
1 Read

Tolerability of long-term fluconazole therapy.

J Antimicrob Chemother 2019 Mar;74(3):768-771

Department of Medical Microbiology and Immunology, University of California, Med Science Dr., Davis, CA, USA.

Background: Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require lifelong treatment. Read More

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http://dx.doi.org/10.1093/jac/dky501DOI Listing
March 2019
2 Reads

Coccidioidomycosis in alpacas in the southwestern United States.

Transbound Emerg Dis 2018 Dec 2. Epub 2018 Dec 2.

Valley Fever Center for Excellence, The University of Arizona, Tucson, Arizona.

An anonymous web-based survey of alpaca owners was used to learn more about the clinical presentation, diagnosis, and treatment of coccidioidomycosis in alpacas in the United States. Thirty-seven owners, with 1,117 alpacas, completed the survey. Over 4% of alpacas included in the study were diagnosed with coccidioidomycosis between 2005 and 2016 (5 post mortem, 46 clinically). Read More

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http://dx.doi.org/10.1111/tbed.13088DOI Listing
December 2018
2 Reads

Selection of Specific Peptides for spp. Obtained from Antigenic Fractions through SDS-PAGE and Western Blot Methods by the Recognition of Sera from Patients with Coccidioidomycosis.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd. Mx. 04510, Mexico.

Antigenic fractions of 100, 50, 37, and 28 kDa obtained through the SDS-PAGE method that were more frequently recognized by anti- antibodies in the sera of coccidioidomycosis patients were selected using western blotting. Subsequently, these bands were sequenced, and the obtained proteins were analysed by BLAST to choose peptides specific for spp. from among the shared aligned sequences of related fungi. Read More

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http://www.mdpi.com/1420-3049/23/12/3145
Publisher Site
http://dx.doi.org/10.3390/molecules23123145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321320PMC
November 2018
7 Reads

Crescendo Transient Ischemic Attacks Due to Basilar Coccidioidal Meningitis With Coccidioma.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618813178. Epub 2018 Nov 19.

Kern Medical-UCLA, Bakersfield, CA, USA.

Coccidioidal meningitis typically presents with symptoms that may include headache, altered mental status including personality changes, fever, nausea, vomiting, gait abnormalities, and focal neurological deficits. This is a case of coccidioidal meningitis that initially presented as 4 consecutive crescendo cerebrovascular transient ischemic attacks with focal neurological deficits that resolved within minutes. Imaging showed a left basilar coccidioma. Read More

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http://dx.doi.org/10.1177/2324709618813178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247484PMC
November 2018
1 Read

Coccidioidomycosis: first cases reported in Pernambuco, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e75. Epub 2018 Nov 14.

Universidade Federal de Pernambuco, Departamento de Micologia, Recife, Pernambuco, Brazil.

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. Read More

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http://dx.doi.org/10.1590/S1678-9946201860075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235429PMC
November 2018
7 Reads

The utility of real-time polymerase chain reaction in detecting Coccidioides immitis among clinical specimens in the Central California San Joaquin Valley.

Med Mycol 2018 Nov 21. Epub 2018 Nov 21.

University of California-San Francisco, Fresno, California, USA.

Coccidioidomycosis, the fungal infection caused by dimorphic Coccidioides species, is typically diagnosed by histopathologic identification of spherules, by culture, or by serology. These tests are reliable but time-intensive, delaying diagnosis and treatment. Rapid real-time polymerase chain reaction (RT-PCR) can be performed and was validated to identify Coccidioides immitis using an in-house developed assay for the Becton Dickinson molecular instrument (BD MAXTM). Read More

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http://dx.doi.org/10.1093/mmy/myy111DOI Listing
November 2018
19 Reads

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Pneumonia.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

VA Healthcare, San Diego, California, USA

Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, and , that are endemic in the southwestern United States and other areas in the Western Hemisphere. Chronic cavitary pulmonary infections and extrapulmonary sites of infection are very difficult to treat and often require lifelong azole therapy. APX001A is the first in a new class of broad-spectrum antifungal agents that inhibit Gwt1, an enzyme which is required for cell wall localization of glycosylphosphatidylinositol (GPI)-anchored mannoproteins in fungi. Read More

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http://dx.doi.org/10.1128/AAC.01715-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355600PMC
February 2019
12 Reads

Complications and Management of a Rare Case of Disseminated Coccidioidomycosis to the Vertebral Spine.

Authors:
Sammy G Nakhla

Case Rep Infect Dis 2018 8;2018:8954016. Epub 2018 Oct 8.

Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA.

Coccidioidomycosis, also known as San Joaquin Valley Fever or Valley Fever, is mostly a pulmonary infection caused by inhalation of spores in an endemic region. Dissemination to bone, joints, meninges, and skin occurs less than one percent of the time. Skeletal involvement accounts for approximately half of the disseminated coccidioidomycosis with the vertebrae as the most common skeletal region. Read More

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https://www.hindawi.com/journals/criid/2018/8954016/
Publisher Site
http://dx.doi.org/10.1155/2018/8954016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218755PMC
October 2018
12 Reads

Gene exchange between two divergent species of the fungal human pathogen, Coccidioides.

Evolution 2019 Jan 4;73(1):42-58. Epub 2018 Dec 4.

Biology Department, University of North Carolina, Chapel Hill, North Carolina.

The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. Read More

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http://dx.doi.org/10.1111/evo.13643DOI Listing
January 2019
1 Read
4.612 Impact Factor

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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http://www.kcdcphrp.org/journal/view.html?doi=10.24171/j.phr
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http://dx.doi.org/10.24171/j.phrp.2018.9.5.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202016PMC
October 2018
8 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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http://dx.doi.org/10.3390/jof4040120DOI Listing
October 2018
2 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
18 Reads

Comparison of two FDA-cleared EIA assays for the detection of Coccidioides antibodies against a composite clinical standard.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Coccidioidomycosis is a disease endemic to the southwestern United States, parts of Mexico, and Central and South America. Diagnosis of the disease is commonly delayed because of the lack of prompt testing and the dearth of reliable diagnostic tests. Culture and nucleic acid testing require a specimen, yet the typical patient presents with a dry cough and no sputum. Read More

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http://dx.doi.org/10.1093/mmy/myy094DOI Listing
October 2018
2 Reads

Corticosteroids in the Management of Severe Coccidioidomycosis.

Am J Med 2019 Jan 2;132(1):110-113. Epub 2018 Oct 2.

Pulmonary, Critical Care and Sleep Section, Infectious Diseases Section, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Background: There is limited data suggesting that recovery from severe pulmonary infection with Coccidioides may be hastened by the addition of systemic corticosteroids.

Methods: We present a case report of 2 patients with persistent and progressive coccidioidomycosis who demonstrated a dramatic response to adjunctive corticosteroid therapy.

Results: Both patients had Coccidioides immitis cultured from respiratory samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183094
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http://dx.doi.org/10.1016/j.amjmed.2018.09.020DOI Listing
January 2019
18 Reads

Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients.

AJNR Am J Neuroradiol 2018 Nov 4;39(11):2148-2153. Epub 2018 Oct 4.

Department of Radiology (J.R.), Mayo Clinic College of Medicine, Phoenix, Arizona.

Background And Purpose: is a dimorphic fungus endemic to the Southwest United States and Mexico, and at our institution, it is a relatively common pathogen presenting with a broad spectrum of associated spine diseases. We describe the various spinal manifestations resulting from coccidioidal infection and provide MR imaging examples from 41 pathologically proved cases.

Materials And Methods: Retrospective electronic medical record and PACS searches were performed. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A5818
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http://dx.doi.org/10.3174/ajnr.A5818DOI Listing
November 2018
4 Reads

Investigating the Relationship Between Climate and Valley Fever (Coccidioidomycosis).

Ecohealth 2018 12 3;15(4):840-852. Epub 2018 Oct 3.

Virginia Polytechnic Institute and State University, 115 Major Williams Hall, Blacksburg, VA, 4061, USA.

Valley fever (coccidioidomycosis) is a disease caused by inhalation of spores from the soil-dwelling Coccidioides fungal species. The disease is endemic to semiarid areas in the western USA and parts of Central and South America. The region of interest for this study, Kern County, California, accounts for approximately 14% of the reported valley fever cases in the USA each year. Read More

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http://link.springer.com/10.1007/s10393-018-1375-9
Publisher Site
http://dx.doi.org/10.1007/s10393-018-1375-9DOI Listing
December 2018
6 Reads

A novel form of intracranial coccidioidomycosis is present in dogs and exhibits characteristic clinical and magnetic resonance imaging findings.

Vet Radiol Ultrasound 2019 Jan 27;60(1):47-55. Epub 2018 Sep 27.

Veterinary Neurological Center, Phoenix, Arizona, 85040.

The neurological examination findings, clinical pathology (including Coccidioides immitis IgG/IgM serology) and magnetic resonance imaging (MRI) findings in 13 dogs with a novel form of intracranial coccidioidomycosis are described in a retrospective case series, with long-term clinical resolution documented in 11/13 dogs (84.6% of cases) with oral fluconazole therapy. The medical records of the Veterinary Neurological Center in Phoenix, Arizona from the years 2000 to 2017 were utilized to search for dogs with appropriate inclusion criteria. Read More

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http://dx.doi.org/10.1111/vru.12688DOI Listing
January 2019
2 Reads

Coccidioidomycosis Complement Fixation Titer Trends in the Age of Antifungals.

J Clin Microbiol 2018 Dec 27;56(12). Epub 2018 Nov 27.

Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA

Coccidioidomycosis is associated with a broad spectrum of illness severity, ranging from asymptomatic or self-limited pulmonary infection to life-threatening manifestations of disseminated disease. Serologic studies before the widespread availability of antifungals established current understanding of serologic kinetics and dynamics. Chart histories and complement fixation (CF) titer trends were analyzed for 434 antifungal-treated coccidioidomycosis patients, who were classified by three infectious disease physicians as having either pulmonary uncomplicated coccidioidomycosis (PUC) ( = 248), pulmonary chronic coccidioidomycosis (PCC) ( = 64), disseminated coccidioidomycosis (DC) not including meningitis ( = 86), or coccidioidal meningitis (CM) ( = 36). Read More

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http://dx.doi.org/10.1128/JCM.01318-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258849PMC
December 2018
2 Reads

Occupational Coccidioidomycosis in a heavy equipment operator.

Authors:
Mark Nicas

J Occup Environ Hyg 2018 Dec;15(12):841-846

a School of Public Health, University of California , Berkeley California.

This article describes a case of Coccidioidomycosis pneumonia in an individual who worked in the McKittrick Oil Field, Kern County, California, for 15 days during an approximate 1-month period in 2016. Coccidioidomycosis is caused by inhaling spores of Coccidioides immitis (C. immitis), a soil fungus endemic in regions of California, most notably the San Joaquin Valley. Read More

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http://dx.doi.org/10.1080/15459624.2018.1524149DOI Listing
December 2018
4 Reads

Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis.

Int J Dermatol 2019 Feb 19;58(2):250-253. Epub 2018 Sep 19.

Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ, USA.

Background: Fluconazole is the most commonly used antifungal treatment for various forms of coccidioidomycosis. Although we had anecdotally observed a high proportion of patients reporting cutaneous adverse effects associated with fluconazole treatment, this observation was not well described in the medical literature, and we were unsure of the additional effect of the arid desert environment of Arizona.

Methods: We performed a one-time, voluntary survey of patients with coccidioidomycosis and compared the responses of patients treated with fluconazole with those of untreated patients. Read More

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http://dx.doi.org/10.1111/ijd.14238DOI Listing
February 2019
3 Reads

Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico.

J Fungi (Basel) 2018 Sep 9;4(3). Epub 2018 Sep 9.

Medical Research Centre for Medical Mycology, Wellcome Trust Strategic Award, Institute of Medical Science, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.

In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016⁻2017 are described. A total of 55 individuals were included. Read More

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http://www.mdpi.com/2309-608X/4/3/109
Publisher Site
http://dx.doi.org/10.3390/jof4030109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162685PMC
September 2018
8 Reads

Multiple Intracranial Aneurysms from Coccidioidal Meningitis: Case Report Featuring Aneurysm Formation and Spontaneous Thrombosis with Literature Review.

World Neurosurg 2019 Jan 7;121:117-123. Epub 2018 Sep 7.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA.

Background: Coccidioidal meningitis can progress to vasculitis with aneurysm formation. Although aneurysmogenesis is rare, it carries exceptionally high mortality. Except in one instance, prior case reports have documented universally fatal consequences. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.220DOI Listing
January 2019
5 Reads

Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity.

Virulence 2018 ;9(1):1426-1435

a Division of Infectious Diseases, Department of Medicine , University of California San Diego School of Medicine , San Diego , CA , USA.

Coccidioides immitis and C. posadasii are two highly pathogenic dimorphic fungal species that are endemic in the arid areas of the new world, including the region from west Texas to southern and central California in the USA that cause coccidioidomycosis (also known as Valley Fever). In highly endemic regions such as southern Arizona, up to 50% of long term residents have been infected. Read More

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https://www.tandfonline.com/doi/full/10.1080/21505594.2018.1
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http://dx.doi.org/10.1080/21505594.2018.1509667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141143PMC
January 2018
15 Reads

Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.

Mycopathologia 2018 Oct 30;183(5):793-803. Epub 2018 Aug 30.

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. Read More

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http://dx.doi.org/10.1007/s11046-018-0295-0DOI Listing
October 2018
3 Reads

Erythema Sweetobullosum: A Reactive Cutaneous Manifestation of Coccidioidomycosis.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618796659. Epub 2018 Aug 24.

Kern Medical Center, Bakersfield, CA, USA.

Reactive cutaneous coccidioidal skin manifestations are commonly noticed during the early stage of coccidioidomycosis. These skin lesions are devoid of any active coccidioidal organism, and the immune trigger mechanisms are not elucidated. We describe 6 cases of unusual reactive cutaneous coccidioidal manifestation, characterized by painful vesiculobullous lesions known as erythema sweetobullosum. Read More

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http://dx.doi.org/10.1177/2324709618796659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109837PMC
August 2018
2 Reads

Endemic Mycoses in Solid Organ Transplant Recipients.

Infect Dis Clin North Am 2018 09;32(3):667-685

Division of Infectious Diseases, University of North Carolina, CB 7030, 130 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address:

The endemic mycoses are a group of thermally dimorphic fungal pathogens occupying a specific geographic range. In North America, the chief endemic mycoses are histoplasmosis, coccidioidomycosis, and blastomycosis. Endemic fungi can cause serious infections in solid organ transplant recipients from primary infection, reactivation of latent disease, or donor-derived infection. Read More

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http://dx.doi.org/10.1016/j.idc.2018.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230265PMC
September 2018
4 Reads

Coccidioidomycosis Outbreak Among Workers Constructing a Solar Power Farm - Monterey County, California, 2016-2017.

MMWR Morb Mortal Wkly Rep 2018 Aug 24;67(33):931-934. Epub 2018 Aug 24.

In January 2017, two local health departments notified the California Department of Public Health (CDPH) of three cases of coccidioidomycosis among workers constructing a solar power installation (solar farm) in southeastern Monterey County. Coccidioidomycosis, or Valley fever, is an infection caused by inhalation of the soil-dwelling fungus Coccidioides, which is endemic in the southwestern United States, including California. After a 1-3 week incubation period, coccidioidomycosis most often causes influenza-like symptoms or pneumonia, but rarely can lead to severe disseminated disease or death (1). Read More

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http://www.cdc.gov/mmwr/volumes/67/wr/mm6733a4.htm?s_cid=mm6
Publisher Site
http://dx.doi.org/10.15585/mmwr.mm6733a4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107319PMC
August 2018
16 Reads

Infectious diseases acquired by international travellers visiting the USA.

J Travel Med 2018 Aug;25(1)

Orlando Health Infectious Disease, University of Central Florida College of Medicine, Orlando, FL, USA.

Background: Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income countries is very frequent. Despite being a top international tourist destination, few sources describe the spectrum of infectious diseases acquired among travellers to the USA.

Methods: We performed a descriptive analysis summarizing demographic and travel characteristics, and clinical diagnoses among non-US-resident international travellers seen during or after travel to the USA at a GeoSentinel clinic from 1 January 1997 through 31 December 2016. Read More

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https://academic.oup.com/jtm/article/doi/10.1093/jtm/tay053/
Publisher Site
http://dx.doi.org/10.1093/jtm/tay053DOI Listing
August 2018
18 Reads

Glucan-chitin particles enhance Th17 response and improve protective efficacy of a multivalent antigen (rCpa1) against pulmonary infection.

Infect Immun 2018 Aug 13. Epub 2018 Aug 13.

Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, TX 78249, USA.

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent, recombinant polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e. Read More

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http://dx.doi.org/10.1128/IAI.00070-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204714PMC
August 2018
6 Reads

Risk Stratification With Coccidioidal Skin Test to Prevent Valley Fever Among Inmates, California, 2015.

J Correct Health Care 2018 Oct 13;24(4):342-351. Epub 2018 Aug 13.

1 Public Health Branch, California Correctional Health Care Services, Elk Grove, CA, USA.

Two California state prisons (A and B) have very high rates of coccidioidomycosis (Valley Fever). The prison health care service sought to improve their prevention strategy by risk stratification with a newly available spherulin-based Coccidioides delayed-type hypersensitivity test. Of the 36,789 voluntarily screened inmates, 4. Read More

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http://dx.doi.org/10.1177/1078345818792679DOI Listing
October 2018
17 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 Aug;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

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https://academic.oup.com/jtm/article/doi/10.1093/jtm/tay055/
Publisher Site
http://dx.doi.org/10.1093/jtm/tay055DOI Listing
August 2018
15 Reads