3,380 results match your criteria Coccidioidomycosis


Health Considerations for HIV-Infected International Travelers.

Curr Infect Dis Rep 2019 Apr 12;21(5):16. Epub 2019 Apr 12.

Harvard Medical School, Boston, MA, USA.

Purpose Of The Review: International travel continues to steadily increase, including leisure travel, travel to one's country of origin to visit friends and relatives, travel for service work, and business travel. Travelers with HIV may have an increased risk for travel-associated infections. The pre-travel medical consultation is an important means of assessing one's risk for travel-related health issues. Read More

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http://dx.doi.org/10.1007/s11908-019-0672-yDOI Listing
April 2019
6 Reads

Effects of Pregnancy, Outdoor Access, and Antifungal Medication on Hair Loss in Breeding-age Female Pigtailed Macaques (Macaca nemestrina).

Comp Med 2019 Apr 10. Epub 2019 Apr 10.

Over 18 mo, adult female pigtailed macaques (Macaca nemestrina) housed at a breeding facility in Arizona were monitoredevery 6 mo for alopecia. The study period coincided with the movement of a majority of animals from primarily outdoor housing to continuous indoor housing and a corresponding decrease in available space. These changes were made due to the newly recognized prevalence of coccidioidomycosis at this site. Read More

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http://dx.doi.org/10.30802/AALAS-CM-18-000108DOI Listing
April 2019
1 Read

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

The Rise of Valley Fever: Prevalence and Cost Burden of Coccidioidomycosis Infection in California.

Int J Environ Res Public Health 2019 Mar 28;16(7). Epub 2019 Mar 28.

Department of Social Sciences, Humanities and Arts, University of California, Merced, CA 95343, USA.

Coccidioidomycosis (CM) is a fungal infection endemic in the southwestern United States (US). In California, CM incidence increased more than 213% (from 6.0/100,000 (2014) to 18. Read More

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https://www.mdpi.com/1660-4601/16/7/1113
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http://dx.doi.org/10.3390/ijerph16071113DOI Listing
March 2019
3 Reads

Endemic Fungal Infections in Solid Organ Transplant Recipients - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Mar 29:e13553. Epub 2019 Mar 29.

Department of Internal Medicine, University of Kansas School of Medicine Wichita, 1100 N Saint Francis St, Wichita, KS, 67214.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of blastomycosis, histoplasmosis and coccidioidomycosis in the pre- and post-transplant period. Though each of these endemic fungal infections has unique epidemiology and clinical manifestations, they all share a predilection for primary pulmonary infection and may cause disseminated infection, particularly in immunocompromised hosts. Culture remains the gold standard for definitive diagnosis, but more rapid diagnosis may be achieved with direct visualization of organisms from clinical specimens and antigen based EIA assays. Read More

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http://dx.doi.org/10.1111/ctr.13553DOI Listing
March 2019
1 Read

[Climate change and systemic fungal infections].

Authors:
Volker Rickerts

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Mar 28. Epub 2019 Mar 28.

FG 16, Erreger von Mykosen, Mykobakteriosen und Parasitosen, Konsiliarlabor für Kryptokokkose und seltene Systemmykosen, Robert Koch-Institut, Seestraße 10, 13353, Berlin, Deutschland.

Background: Climate change may cause profound and complex changes in the prevalence of infectious diseases. Obligate pathogenic fungi causing endemic mycoses and the agents of cryptococcosis are environmental pathogens adapted to environmental niches. They may be exposed to changing climatic conditions, which may change the epidemiology of human infections. Read More

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http://dx.doi.org/10.1007/s00103-019-02931-zDOI Listing
March 2019
1 Read

Coccidioidomycosis with emperipolesis in fine needle aspiration.

Cytopathology 2019 Mar 25. Epub 2019 Mar 25.

Grosse Claudia, Pathology, Kepler University Hospital, Krankenhausstraße 9, 4021, Linz, Austria.

Emperipolesis, first described by Humble et al in 1956 , is the invasion of a viable, intact cell by another cell, while the term phagocytosis designates the engulfment of a cell that is destroyed by lysosomal enzymes. Since its first description, emperipolesis has been reported in several entities. It is the hallmark feature of Rosai-Dorfman disease, where intact lymphocytes, plasma cells or erythrocytes are seen within the cytoplasm of histiocytes, and it has been reported in cases of Erdheim-Chester disease, inflammatory myxohyaline tumour , myelodysplastic syndrome and rarely B- and T-cell lymphoma. Read More

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http://dx.doi.org/10.1111/cyt.12694DOI Listing
March 2019
1 Read

The mysterious desert dwellers: Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis.

Virulence 2019 12;10(1):222-233

a Pathogen and Microbiome Institute , Northern Arizona University , Flagstaff , AZ , USA.

The genus Coccidioides consists of two species: C. immitis and C. posadasii. Read More

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http://dx.doi.org/10.1080/21505594.2019.1589363DOI Listing
December 2019
1 Read
4.216 Impact Factor

Optical Coherence Tomography Angiography Highlights Chorioretinal Lesions in Ocular Coccidioidomycosis.

Ophthalmic Surg Lasers Imaging Retina 2019 Mar;50(3):e71-e73

A 34-year-old woman presented after recovering from a disseminated Coccidioides immitis infection of the lungs, blood, brain, and placenta. The patient was asymptomatic for visual complaints. Visual acuity was 20/20 in both eyes. Read More

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http://dx.doi.org/10.3928/23258160-20190301-14DOI Listing
March 2019
2 Reads

Laboratory exposure to Coccidioides: lessons learnt in a non-endemic country.

J Hosp Infect 2019 Mar 16. Epub 2019 Mar 16.

Laboratorio Clínico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile; Programa Medicina del Viajero, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, laboratory personnel might become infected during diagnostic procedures. Accordingly, coccidioidomycosis is reported as the most frequent laboratory-acquired systemic mycosis worldwide. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.03.006DOI Listing
March 2019
1 Read

Coccidioidomycosis Among American Indians and Alaska Natives, 2001-2014.

Open Forum Infect Dis 2019 Mar 11;6(3):ofz052. Epub 2019 Mar 11.

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: American Indians and Alaska Natives (AI/ANs) may be uniquely vulnerable to coccidioidomycosis given the large population residing in the Southwestern United States. We describe coccidioidomycosis-associated hospitalizations and outpatient visits during 2001-2014 in the Indian Health Service (IHS) system and compare hospitalizations with data from the Agency for Healthcare Research and Quality's National (Nationwide) Inpatient Sample (NIS).

Methods: We identified hospitalizations in the IHS and the NIS and outpatient visits in the IHS using (ICD-9-CM) codes 114. Read More

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http://dx.doi.org/10.1093/ofid/ofz052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411209PMC
March 2019
2 Reads

De novo coccidioidomycosis among solid organ transplant recipients 1 or more years after transplant.

Am J Transplant 2019 Feb 27. Epub 2019 Feb 27.

Division of Infectious Diseases, Banner University Medical Center, University of Arizona, Tucson, Arizona.

Solid organ transplant recipients who contract coccidioidomycosis are at risk for complicated, protracted, disseminated, and severe disease. To date, no studies have described outcomes for patients who develop coccidioidomycosis only after the first posttransplant year. This study was a joint project of Mayo Clinic Hospital, Phoenix, Arizona, and the University of Arizona/Banner University Medical Center, Tucson, Arizona. Read More

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http://dx.doi.org/10.1111/ajt.15324DOI Listing
February 2019
2 Reads

Dendritic cell-based immunization induces Coccidioides Ag2/PRA-specific immune response.

Vaccine 2019 Mar 20;37(12):1685-1691. Epub 2019 Feb 20.

Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Valley Fever, or coccidioidomycosis, is caused by a soil-borne, highly virulent fungal pathogen, Coccidioides spp. Infection with Coccidioides can be life-threatening. Since an effective treatment is not available and the T cell-mediated immune response is protective, vaccine development is of interest. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.034DOI Listing

Utility of Whole-Genome Sequencing to Ascertain Locally Acquired Cases of Coccidioidomycosis, Washington, USA.

Emerg Infect Dis 2019 Mar;25(3):501-506

Coccidioidomycosis is an emerging fungal infection in Washington, USA, and the epidemiology of the disease in this state is poorly understood. We used whole-genome sequencing to differentiate locally acquired cases in Washington on the basis of the previously identified phylogeographic population structure of Coccidioides spp. Clinical isolates from coccidioidomycosis cases involving possible Washington soil exposure were included. Read More

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http://dx.doi.org/10.3201/eid2503.181155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390764PMC
March 2019
1 Read

Clinical features of cats diagnosed with coccidioidomycosis in Arizona, 2004-2018.

J Feline Med Surg 2019 Feb 20:1098612X19829910. Epub 2019 Feb 20.

2 Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA.

Objectives: The goal of this study was to describe the clinical presentation, diagnosis and treatment of coccidioidomycosis in cats residing in a region endemic for Coccidioides species.

Methods: A retrospective review of records was performed at both primary and tertiary care veterinary practices in Tucson and Phoenix, Arizona. Data collected included signalment, clinical signs, physical examination findings, diagnostic test results, treatment and outcome. Read More

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http://dx.doi.org/10.1177/1098612X19829910DOI Listing
February 2019
2 Reads

Coccidioidal Meningitis in New York traced to Texas by Fungal Genomic Analysis.

Clin Infect Dis 2019 Feb 1. Epub 2019 Feb 1.

Valley Fever Center for Excellence and Department of Medicine, University of Arizona College of Medicine, Tucson, Tucson Arizona.

A child developed hydrocephalus. Sixteen months later, it was discovered to be a complication of coccidioidal meningitis. The infection's source was uncertain until genomic analysis of the fungal isolate identified its origin to be a visit to Beeville Texas. Read More

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http://dx.doi.org/10.1093/cid/ciz052DOI Listing
February 2019
2 Reads
8.886 Impact Factor

Coccidioidomycosis: What a long strange trip it's been.

Med Mycol 2019 Feb;57(Supplement_1):S3-S15

California Institute for Medical Research, San Jose, California, USA.

The recorded history of coccidioidomycosis began in 1892 with the report of the illness of Domingo Escurra by Alejandro Posadas followed by a description of the first North American cases by Rixford and Gilchrist. Originally considered a protozoan, William Ophüls determined that Coccidioides was a fungus and that the lungs were the apparent initial site of infection. During the 1930s, both Gifford and Dickson determined that a self-limited illness, Valley Fever, was caused by the same fungus that caused the often fatal coccidioidal granuloma. Read More

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http://dx.doi.org/10.1093/mmy/myy123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347081PMC
February 2019
2 Reads

Coccidioides ecology and genomics.

Med Mycol 2019 Feb;57(Supplement_1):S21-S29

Department of Microbiology, Centro de Investigación Científica y Educación Superior de Ensenada (CICESE), Ctra. Ensenada-Tijuana No. 3918, Ensenada, Baja California, 22860, Mexico.

Although the natural history and ecology of Coccidioides spp. have been studied for over 100 years, many fundamental questions about this fungus remain unanswered. Two of the most challenging aspects of the study of Coccidioides have been the undefined ecological niche and the outdated geographic distribution maps dating from midcentury. Read More

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http://dx.doi.org/10.1093/mmy/myy051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347077PMC
February 2019
6 Reads
2.335 Impact Factor

The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species.

Med Mycol 2019 Feb;57(Supplement_1):S16-S20

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.

The prevailing hypothesis concerning the ecology of Coccidioides immitis and C. posadasii is that these human pathogenic fungi are soil fungi endemic to hot, dry, salty regions of the New World and that humans and the local, small-mammal fauna are only accidental hosts. Here we advance an alternative hypothesis that Coccidioides spp. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S16/530
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http://dx.doi.org/10.1093/mmy/myy039DOI Listing
February 2019
9 Reads
2.335 Impact Factor

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
7 Reads

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S76-S84

Division of Infectious Diseases, UT Health San Antonio, and the South Texas Veterans Health Care System; San Antonio, Texas, USA.

Coccidioidomycosis remains a significant clinical problem with substantial morbidity and mortality. The vast majority of infections are asymptomatic and the need for early primary therapy remains controversial. The use of triazole antifungals has improved tolerability of therapy but concerns about acute and long-term toxicities among available agents limit their use. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S76/530
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http://dx.doi.org/10.1093/mmy/myy029DOI Listing
February 2019
20 Reads

Selected Clinical Features of Coccidioidomycosis in Dogs.

Med Mycol 2019 Feb;57(Supplement_1):S67-S75

School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Canine coccidioidomycosis, a systemic fungal infection endemic to arid and semiarid regions of North, Central, and South America, is commonly diagnosed in dogs living in or traveling through lower Sonoran life zones in the states of California and Arizona. Canine and human cases have geographic overlap. Similarities between clinical coccidioidomycosis in dogs and humans include asymptomatic infection, primary respiratory disease and disseminated disease. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S67/530
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http://dx.doi.org/10.1093/mmy/myy113DOI Listing
February 2019
9 Reads

Update on the Epidemiology of coccidioidomycosis in the United States.

Med Mycol 2019 Feb;57(Supplement_1):S30-S40

Maricopa County Department of Public Health, Phoenix, Arizona, USA.

The incidence of reported coccidioidomycosis in the past two decades has increased greatly; monitoring its changing epidemiology is essential for understanding its burden on patients and the healthcare system and for identifying opportunities for prevention and education. We provide an update on recent coccidioidomycosis trends and public health efforts nationally and in Arizona, California, and Washington State. In Arizona, enhanced surveillance shows that coccidioidomycosis continues to be associated with substantial morbidity. Read More

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http://dx.doi.org/10.1093/mmy/myy095DOI Listing
February 2019
3 Reads

Epidemiology of coccidioidomycosis among children in California, 2000-2016.

Med Mycol 2019 Feb;57(Supplement_1):S64-S66

Infectious Diseases Branch, California Department of Public Health, Richmond, California.

We calculated population-based incidence of coccidioidomycosis from the 2000-2016 California surveillance data and compared children (≤17 years) with adults (≥18 years). During that time, the annual pediatric incidence per 100,000 increased from 0.8 in 2000 to 5. Read More

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http://dx.doi.org/10.1093/mmy/myy066DOI Listing
February 2019
5 Reads

Coccidioidomycosis in Latin America.

Med Mycol 2019 Feb;57(Supplement_1):S46-S55

CIPTIR, Hospital Universitario de Monterrey UANL, Mexico.

Coccidioidomycosis is a highly prevalent systemic mycosis in Latin America and has been reported (human and zoonotic cases) in México, Guatemala, Honduras, Colombia, Venezuela, Brazil, Paraguay, Bolivia, and Argentina. The incidence of coccidioidomycosis in Latin America is unknown due to lack of clinical awareness and limited access to laboratory diagnosis. Coccidioidomycosis is as prevalent in Mexico as in the endemic regions of the United States. Read More

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http://dx.doi.org/10.1093/mmy/myy037DOI Listing
February 2019
3 Reads

Occupational coccidioidomycosis surveillance and recent outbreaks in California.

Med Mycol 2019 Feb;57(Supplement_1):S41-S45

United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.

Workers in Coccidioides-endemic areas performing soil-disturbing work or exposed to windy and dusty conditions are at increased risk for coccidioidomycosis. Four occupational coccidioidomycosis outbreaks from 2007 to 2014 in California are described, involving construction workers in a number of excavation projects and an outdoor filming event involving cast and crew. These outbreaks highlight the importance of identifying industries and occupations at high risk for coccidioidomycosis, conducting targeted occupational health surveillance to assess the burden of illness, developing and implementing prevention strategies, and setting research priorities. Read More

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http://dx.doi.org/10.1093/mmy/myy031DOI Listing
February 2019
5 Reads

Valley Fever on the Rise-Searching for Microbial Antagonists to the Fungal Pathogen .

Microorganisms 2019 Jan 24;7(2). Epub 2019 Jan 24.

Monterey County Health Department, 1270 Natividad, Salinas, CA 93906, USA.

The incidence of coccidioidomycosis, also known as Valley Fever, is increasing in the Southwestern United States and Mexico. Despite considerable efforts, a vaccine to protect humans from this disease is not forthcoming. The aim of this project was to isolate and phylogenetically compare bacterial species that could serve as biocontrol candidates to suppress the growth of , the causative agent of coccidioidomycosis, in eroded soils or in areas close to human settlements that are being developed. Read More

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http://dx.doi.org/10.3390/microorganisms7020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406340PMC
January 2019
4 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
4 Reads

Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

MiraVista Diagnostics LLC. Indianapolis, Indiana, USA.

The diagnosis of coccidioidomycosis (CM) in dogs is typically based on clinical presentation, serology, and (less frequently) spherule identification. Agar gel immunodiffusion (AGID) is the most commonly employed serological method, but AGID is slow (requiring up to a week for titer). A Coccidioides antigen enzyme immunoassay (EIA) is also available; however, sensitivity is low in CM dogs. Read More

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http://dx.doi.org/10.1093/mmy/myy157DOI Listing
January 2019
2 Reads

Patient With a 42-Year History of Coccidioidal Meningitis.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820047. Epub 2018 Dec 20.

Kern Medical-UCLA, Bakersfield, CA, USA.

This is a case of a 56-year-old man diagnosed with coccidioidal meningitis 42 years ago at the age of 14. He was treated with intrathecal amphotericin B deoxycholate by cisternal puncture for 15 years before switching to fluconazole once it became available in 1991. Over 42 years of treatment, he developed hearing loss due to auditory nerve neurotoxicity, hydrocephalus requiring ventriculoperitoneal shunting with associated malfunctions, lumbar arachnoiditis, and hypokalemic paralysis. Read More

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http://dx.doi.org/10.1177/2324709618820047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302271PMC
December 2018
8 Reads

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2019 Mar 1;62(3):268-273. Epub 2019 Jan 1.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380936PMC
March 2019
8 Reads

Autochthonous Transmission of Coccidioides in Animals, Washington, USA.

Emerg Infect Dis 2019 01;25(1):123-125

We report 5 cases of coccidioidomycosis in animals that were acquired within Washington, USA, and provide further evidence for the environmental endemicity of Coccidioides immitis within the state. Veterinarians should consider coccidioidomycosis in animals with compatible clinical signs that reside in, or have traveled to, south central Washington. Read More

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http://dx.doi.org/10.3201/eid2501.180411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302573PMC
January 2019
2 Reads

Tolerability of long-term fluconazole therapy.

J Antimicrob Chemother 2019 Mar;74(3):768-771

Department of Medical Microbiology and Immunology, University of California, Med Science Dr., Davis, CA, USA.

Background: Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require lifelong treatment. Read More

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http://dx.doi.org/10.1093/jac/dky501DOI Listing
March 2019
8 Reads

Coccidioidomycosis in alpacas in the southwestern United States.

Transbound Emerg Dis 2019 Mar 14;66(2):807-812. Epub 2018 Dec 14.

Valley Fever Center for Excellence, The University of Arizona, Tucson, Arizona.

An anonymous web-based survey of alpaca owners was used to learn more about the clinical presentation, diagnosis, and treatment of coccidioidomycosis in alpacas in the United States. Thirty-seven owners, with 1,117 alpacas, completed the survey. Over 4% of alpacas included in the study were diagnosed with coccidioidomycosis between 2005 and 2016 (5 post mortem, 46 clinically). Read More

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http://dx.doi.org/10.1111/tbed.13088DOI Listing
March 2019
5 Reads

Selection of Specific Peptides for spp. Obtained from Antigenic Fractions through SDS-PAGE and Western Blot Methods by the Recognition of Sera from Patients with Coccidioidomycosis.

Molecules 2018 Nov 30;23(12). Epub 2018 Nov 30.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México Cd. Mx. 04510, Mexico.

Antigenic fractions of 100, 50, 37, and 28 kDa obtained through the SDS-PAGE method that were more frequently recognized by anti- antibodies in the sera of coccidioidomycosis patients were selected using western blotting. Subsequently, these bands were sequenced, and the obtained proteins were analysed by BLAST to choose peptides specific for spp. from among the shared aligned sequences of related fungi. Read More

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http://www.mdpi.com/1420-3049/23/12/3145
Publisher Site
http://dx.doi.org/10.3390/molecules23123145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321320PMC
November 2018
14 Reads

Crescendo Transient Ischemic Attacks Due to Basilar Coccidioidal Meningitis With Coccidioma.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618813178. Epub 2018 Nov 19.

Kern Medical-UCLA, Bakersfield, CA, USA.

Coccidioidal meningitis typically presents with symptoms that may include headache, altered mental status including personality changes, fever, nausea, vomiting, gait abnormalities, and focal neurological deficits. This is a case of coccidioidal meningitis that initially presented as 4 consecutive crescendo cerebrovascular transient ischemic attacks with focal neurological deficits that resolved within minutes. Imaging showed a left basilar coccidioma. Read More

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http://dx.doi.org/10.1177/2324709618813178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247484PMC
November 2018
2 Reads

Coccidioidomycosis: first cases reported in Pernambuco, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e75. Epub 2018 Nov 14.

Universidade Federal de Pernambuco, Departamento de Micologia, Recife, Pernambuco, Brazil.

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. Read More

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http://dx.doi.org/10.1590/S1678-9946201860075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235429PMC
November 2018
14 Reads

The utility of real-time polymerase chain reaction in detecting Coccidioides immitis among clinical specimens in the Central California San Joaquin Valley.

Med Mycol 2018 Nov 21. Epub 2018 Nov 21.

University of California-San Francisco, Fresno, California, USA.

Coccidioidomycosis, the fungal infection caused by dimorphic Coccidioides species, is typically diagnosed by histopathologic identification of spherules, by culture, or by serology. These tests are reliable but time-intensive, delaying diagnosis and treatment. Rapid real-time polymerase chain reaction (RT-PCR) can be performed and was validated to identify Coccidioides immitis using an in-house developed assay for the Becton Dickinson molecular instrument (BD MAXTM). Read More

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http://dx.doi.org/10.1093/mmy/myy111DOI Listing
November 2018
24 Reads

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Pneumonia.

Antimicrob Agents Chemother 2019 Feb 29;63(2). Epub 2019 Jan 29.

VA Healthcare, San Diego, California, USA

Coccidioidomycosis is a systemic fungal infection caused by the inhalation of the arthroconidia of either of two closely related dimorphic fungi, and , that are endemic in the southwestern United States and other areas in the Western Hemisphere. Chronic cavitary pulmonary infections and extrapulmonary sites of infection are very difficult to treat and often require lifelong azole therapy. APX001A is the first in a new class of broad-spectrum antifungal agents that inhibit Gwt1, an enzyme which is required for cell wall localization of glycosylphosphatidylinositol (GPI)-anchored mannoproteins in fungi. Read More

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http://dx.doi.org/10.1128/AAC.01715-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355600PMC
February 2019
28 Reads

Complications and Management of a Rare Case of Disseminated Coccidioidomycosis to the Vertebral Spine.

Authors:
Sammy G Nakhla

Case Rep Infect Dis 2018 8;2018:8954016. Epub 2018 Oct 8.

Department of Medicine, Southern Arizona VA Health Care System, Tucson, AZ 85723, USA.

Coccidioidomycosis, also known as San Joaquin Valley Fever or Valley Fever, is mostly a pulmonary infection caused by inhalation of spores in an endemic region. Dissemination to bone, joints, meninges, and skin occurs less than one percent of the time. Skeletal involvement accounts for approximately half of the disseminated coccidioidomycosis with the vertebrae as the most common skeletal region. Read More

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https://www.hindawi.com/journals/criid/2018/8954016/
Publisher Site
http://dx.doi.org/10.1155/2018/8954016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218755PMC
October 2018
18 Reads

Gene exchange between two divergent species of the fungal human pathogen, Coccidioides.

Evolution 2019 Jan 4;73(1):42-58. Epub 2018 Dec 4.

Biology Department, University of North Carolina, Chapel Hill, North Carolina.

The fungal genus Coccidioides is composed of two species, Coccidioides immitis and Coccidioides posadasii. These two species are the causal agents of coccidioidomycosis, a pulmonary disease also known as valley fever. The two species are thought to have shared genetic material due to gene exchange in spite of their long divergence. Read More

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http://dx.doi.org/10.1111/evo.13643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430640PMC
January 2019
6 Reads
4.612 Impact Factor

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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http://www.kcdcphrp.org/journal/view.html?doi=10.24171/j.phr
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http://dx.doi.org/10.24171/j.phrp.2018.9.5.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202016PMC
October 2018
18 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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http://dx.doi.org/10.3390/jof4040120DOI Listing
October 2018
3 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
22 Reads

Comparison of two FDA-cleared EIA assays for the detection of Coccidioides antibodies against a composite clinical standard.

Med Mycol 2018 Oct 16. Epub 2018 Oct 16.

Division of Infectious Diseases, Department of Medicine, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Coccidioidomycosis is a disease endemic to the southwestern United States, parts of Mexico, and Central and South America. Diagnosis of the disease is commonly delayed because of the lack of prompt testing and the dearth of reliable diagnostic tests. Culture and nucleic acid testing require a specimen, yet the typical patient presents with a dry cough and no sputum. Read More

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http://dx.doi.org/10.1093/mmy/myy094DOI Listing
October 2018
7 Reads

Corticosteroids in the Management of Severe Coccidioidomycosis.

Am J Med 2019 Jan 2;132(1):110-113. Epub 2018 Oct 2.

Pulmonary, Critical Care and Sleep Section, Infectious Diseases Section, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, Calif.

Background: There is limited data suggesting that recovery from severe pulmonary infection with Coccidioides may be hastened by the addition of systemic corticosteroids.

Methods: We present a case report of 2 patients with persistent and progressive coccidioidomycosis who demonstrated a dramatic response to adjunctive corticosteroid therapy.

Results: Both patients had Coccidioides immitis cultured from respiratory samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183094
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http://dx.doi.org/10.1016/j.amjmed.2018.09.020DOI Listing
January 2019
20 Reads

Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients.

AJNR Am J Neuroradiol 2018 Nov 4;39(11):2148-2153. Epub 2018 Oct 4.

Department of Radiology (J.R.), Mayo Clinic College of Medicine, Phoenix, Arizona.

Background And Purpose: is a dimorphic fungus endemic to the Southwest United States and Mexico, and at our institution, it is a relatively common pathogen presenting with a broad spectrum of associated spine diseases. We describe the various spinal manifestations resulting from coccidioidal infection and provide MR imaging examples from 41 pathologically proved cases.

Materials And Methods: Retrospective electronic medical record and PACS searches were performed. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A5818
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http://dx.doi.org/10.3174/ajnr.A5818DOI Listing
November 2018
5 Reads

Investigating the Relationship Between Climate and Valley Fever (Coccidioidomycosis).

Ecohealth 2018 12 3;15(4):840-852. Epub 2018 Oct 3.

Virginia Polytechnic Institute and State University, 115 Major Williams Hall, Blacksburg, VA, 4061, USA.

Valley fever (coccidioidomycosis) is a disease caused by inhalation of spores from the soil-dwelling Coccidioides fungal species. The disease is endemic to semiarid areas in the western USA and parts of Central and South America. The region of interest for this study, Kern County, California, accounts for approximately 14% of the reported valley fever cases in the USA each year. Read More

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http://link.springer.com/10.1007/s10393-018-1375-9
Publisher Site
http://dx.doi.org/10.1007/s10393-018-1375-9DOI Listing
December 2018
6 Reads