3,691 results match your criteria Coccidioidomycosis

A Case of Concurrent Disseminated Coccidioidomycosis and Embryonal Carcinoma When Lice and Fleas Coexist.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221098339

Department of Internal Medicine, Division of Infectious Diseases, UCLA at Kern Medical Center, Bakersfield, CA, USA.

Coccidioidomycosis (CM) is a fungal infection endemic to the southwestern United States with a wide range of clinical presentations depending on the infected organ systems. Most infections are asymptomatic. Coccidioidomycosis causes a primary pulmonary infection and when symptoms occur, they most often resemble community-acquired pneumonia. Read More

View Article and Full-Text PDF

Comparison of shunt outcomes for non-bacterial infectious hydrocephalus with common hydrocephalus etiologies: a retrospective case-control study.

World Neurosurg 2022 May 9. Epub 2022 May 9.

Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.

Background: Shunting is an established treatment for hydrocephalus, yet reports on shunt outcomes for non-bacterial infectious (NBI) hydrocephalus are limited. Furthermore, comparison of mechanisms and rates of failure for shunted NBI hydrocephalus versus more typical etiologies remains undetermined.

Methods: Patients who underwent shunting for hydrocephalus at two centers (1995-2020) were included. Read More

View Article and Full-Text PDF

Disseminated coccidioidomycosis in immunocompetent patients in non-endemic areas: a case series and literature review.

Eur J Clin Microbiol Infect Dis 2022 May 12. Epub 2022 May 12.

Department of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Coccidioidomycosis is caused by the dimorphic fungi Coccidioides species which is endemic in the Western hemisphere. Reports on the characteristics of travel-related disseminated coccidioidomycosis in immunocompetent patients are rare, especially in non-endemic regions. The multifaceted symptoms of this condition present a diagnostic challenge to clinicians. Read More

View Article and Full-Text PDF

Retrospective evaluation of the efficacy of fluconazole for the treatment of coccidioidomycosis in dogs: 49 cases (2015-2020).

J Am Vet Med Assoc 2022 May 11:1-6. Epub 2022 May 11.

1Department of Specialty Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ.

Objective: To characterize the clinical course and therapeutic response in dogs with coccidioidomycosis treated with fluconazole.

Animals: 49 client-owned dogs with coccidioidomycosis that were treated with fluconazole and had ≥ 2 follow-up examinations.

Procedures: Medical records were retrospectively searched to identify dogs in which coccidioidomycosis was diagnosed between January 2015 and May 2020. Read More

View Article and Full-Text PDF

A 9-Month-Old Boy With "3 Months of Croup" a Devil Inside.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211066392

UCLA Kern Medical, Bakersfield, CA, USA.

Coccidioidomycosis (CM) is an endemic fungal disease that is prevalent in the Southwestern United States, Mexico, and Central and South America. The majority of cases are asymptomatic. Symptomatic cases primarily present with pneumonic disease, varying in severity from mild to severe. Read More

View Article and Full-Text PDF

North American Endemic Fungal Infections.

Jeffrey P Kanne

Radiol Clin North Am 2022 May;60(3):409-427

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue MC 3252, Madison, WI 53792-3252, USA. Electronic address:

Histoplasmosis, blastomycosis, and coccidioidomycosis are endemic fungal infections in North America. Many infections are subclinical, and many symptomatic infections are mild. Pneumonia is the most common clinical manifestation. Read More

View Article and Full-Text PDF

Let's talk about Sex Characteristics - as a Risk Factor for Invasive Fungal Diseases.

Mycoses 2022 Apr 28. Epub 2022 Apr 28.

Durham County Department of Public Health, Durham, NC, USA.

Biological sex, which comprises differences in host sex hormone homeostasis and immune responses, can have a substantial impact on the epidemiology of infectious diseases. Comprehensive data on sex distributions in invasive fungal diseases (IFDs) is lacking. In this review we performed a literature search of in vitro/animal studies, clinical studies, systematic reviews, and meta-analyses of invasive fungal infections. Read More

View Article and Full-Text PDF

Current Landscape of Coccidioidomycosis.

J Fungi (Basel) 2022 Apr 17;8(4). Epub 2022 Apr 17.

Department of Chemistry, University of Colorado, Boulder, CO 80309, USA.

Coccidioidomycosis, also known as Valley fever, is an endemic fungal infection commonly found in the southwestern parts of the United States. However, the disease has seen an increase in both in its area of residency and its prevalence. This review compiles some of the latest information on the epidemiology, current and in-development pharmaceutical approaches to treat the disease, trends and projections, diagnostic concerns, and the overlapping dynamics of coccidioidomycosis and COVID-19, including in special populations. Read More

View Article and Full-Text PDF

Coccidioidomycosis and COVID-19 Infection. An Analysis from a Single Medical Center Within the Coccidioidal Endemic Area.

Mycopathologia 2022 Jun 15;187(2-3):199-204. Epub 2022 Apr 15.

The Division of Infectious Diseases of Mayo Clinic in Arizona, 5777 E. Mayo Blvd, Phoenix, AZ, 85054, USA.

At a single medical center, we identified 60 cases of coccidioidomycosis that were coincident with COVID-19 infection. Among these, seven patients developed new or clinically progressive coccidioidomycosis. Receipt of dexamethasone for COVID-19 infection was the only significant risk factor for the progression or development of clinically active coccidioidomycosis in this cohort. Read More

View Article and Full-Text PDF

A Case of Thyroidal Coccidioidal Infection.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221090840

Kern Medical, Bakersfield, CA, USA.

Infection of the thyroid gland with is rare. We report a case with disseminated coccidiomycosis involving thyroid gland as a thyroid nodule. Although historical autopsy studies have indicated that coccidioidal involvement of the thyroid gland can infrequently occur as part of disseminated infection, to our knowledge, only less than 10 other cases have been reported. Read More

View Article and Full-Text PDF

Pediatric Musculoskeletal Coccidioidomycosis in Central California: A Single Center Experience.

Pediatr Infect Dis J 2022 Apr 5. Epub 2022 Apr 5.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.

Background: Published literature on musculoskeletal coccidioidomycosis is sparse and limited to case reports and case series. This is one of the largest case series to describe the clinical presentation, diagnosis, medical and surgical management and outcomes of pediatric musculoskeletal coccidioidomycosis at a tertiary care hospital.

Method: A retrospective case review was performed on patients ≤ 21 years old who were followed at a tertiary care center with a diagnosis of musculoskeletal coccidioidomycosis from January 1, 2007, to December 31, 2020. Read More

View Article and Full-Text PDF

The WOPR family protein Ryp1 is a key regulator of gene expression, development, and virulence in the thermally dimorphic fungal pathogen Coccidioides posadasii.

PLoS Pathog 2022 04 6;18(4):e1009832. Epub 2022 Apr 6.

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America.

Coccidioides spp. are mammalian fungal pathogens endemic to the Southwestern US and other desert regions of Mexico, Central and South America, with the bulk of US infections occurring in California and Arizona. In the soil, Coccidioides grows in a hyphal form that differentiates into 3-5 micron asexual spores (arthroconidia). Read More

View Article and Full-Text PDF

Pulmonary Giant Cavitary Coccidioides With Fungal Ball and Hemoptysis.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084852

UCLA-Kern Medical, Bakersfield, CA, USA.

Coccidioidomycosis (CM) is a fungal disease that results from inhalation of spores of and . If symptomatic, disease primarily manifests as community-acquired pneumonia; however, additional pulmonary manifestations such as pleural effusion, empyema, and cavitation may occur. Diabetic patients have an increased risk of severe and cavitary CM. Read More

View Article and Full-Text PDF

Skeletal Infections Caused by Species.

Diagnostics (Basel) 2022 Mar 15;12(3). Epub 2022 Mar 15.

Department of Orthopaedics and Traumatology, "Venizeleion" General Hospital of Crete, 71409 Heraklion, Greece.

Background: Coccidioidomycosis represents an endemic and challenging disease, with rare extrapulmonary manifestations. The present review of all published cases of core and extremities osseous coccidioidomycosis aims to describe epidemiology, patients' characteristics, symptoms as well as medical and surgical treatment options and their effectiveness.

Methods: A thorough review of all published skeletal core and extremity infections due to species was conducted. Read More

View Article and Full-Text PDF

PM10 and Other Climatic Variables Are Important Predictors of Seasonal Variability of Coccidioidomycosis in Arizona.

Microbiol Spectr 2022 Apr 23;10(2):e0148321. Epub 2022 Mar 23.

Pathogen and Microbiome Institute, Northern Arizona Universitygrid.261120.6, Flagstaff, Arizona, USA.

Coccidioidomycosis (Valley fever) is a disease caused by the fungal pathogens Coccidioides immitis and Coccidioides posadasii that are endemic to the southwestern United States and parts of Mexico and South America. Throughout the range where the pathogens are endemic, there are seasonal patterns of infection rates that are associated with certain climatic variables. Previous studies that looked at annual and monthly relationships of coccidioidomycosis and climate suggest that infection numbers are linked with precipitation and temperature fluctuations; however, these analytic methods may miss important nonlinear, nonmonotonic seasonal relationships between the response (Valley fever cases) and explanatory variables (climate) influencing disease outbreaks. Read More

View Article and Full-Text PDF

Coccidioidomycosis Cases at a Regional Referral Center, West Texas, USA, 2013-2019.

Emerg Infect Dis 2022 04;28(4):848-851

We describe 73 patients with coccidioidomycosis diagnosed or treated at a regional referral center in West Texas, USA. Patients most at risk worked in oil production or agriculture; the most-associated health factors were smoking and diabetes. Patient demographics suggest that access to care may affect coccidioidomycosis diagnosis in this region. Read More

View Article and Full-Text PDF

(Ig)Easy diagnosis of disseminated coccidioidomycosis.

BMJ Case Rep 2022 Mar 8;15(3). Epub 2022 Mar 8.

Infectious Diseases, Creighton University, Omaha, Nebraska, USA

An immunocompetent man in his 20s came to the hospital for shortness of breath, fevers and lower back pain with unintentional 20 lbs. weight loss. Relevant history included a recent trip to Arizona 3 months prior to presentation. Read More

View Article and Full-Text PDF

Sex Differences in Susceptibility to Coccidioidomycosis.

Open Forum Infect Dis 2022 Mar 16;9(3):ofab543. Epub 2022 Feb 16.

University of California Davis Center for Valley Fever, Sacramento, California, USA.

To assess sex-specific differences in coccidioidomycosis, a retrospective analysis of human patients, nonhuman primates, and veterinary patients (including the neutered status of the animal) was performed. We found higher rates of infection and severity in males. This observed increased infection risk suggests deeper biological underpinnings than solely occupational/exposure risks. Read More

View Article and Full-Text PDF

Diagnosis of disseminated coccidioidomycosis in pregnancy through placental pathology: A case report.

Case Rep Womens Health 2022 Apr 16;34:e00399. Epub 2022 Feb 16.

Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, Kaiser Permanente Southern California, West Los Angeles Medical Center and Discovery Plaza Medical Offices, 6041 Cadillac Ave 3rd Floor, Los Angeles, CA 90034, USA.

There are more than 150,000 new cases of coccidioidomycosis annually in the United States and the incidence is increasing. Although the majority of cases result in mild or no symptoms, pregnancy is a risk factor for complicated and disseminated disease. Overall, coccidioidomycosis is rare in pregnancy and there have been few reports in the literature of dissemination into the placenta. Read More

View Article and Full-Text PDF

Coccidioidomycosis: A Contemporary Review.

Nancy F Crum

Infect Dis Ther 2022 Apr 1;11(2):713-742. Epub 2022 Mar 1.

Infectious Diseases Department, Scripps Health System, San Diego, CA, USA.

Coccidioidomycosis, colloquially known as Valley Fever, is an invasive dimorphic fungal infection caused by Coccidioides immitis and C. posadasii. The fungi are found in the arid desert soils of the southwestern US, as well as in parts of Mexico and Central and South America. Read More

View Article and Full-Text PDF

Thinking Beyond Bacterial Infection: A Case of Cutaneous Blastomycosis.

Cureus 2022 Jan 26;14(1):e21634. Epub 2022 Jan 26.

Hematology/Oncology, Henry Ford Health System, Detroit, USA.

Blastomycosis is caused by , a dimorphic fungus that primarily causes pulmonary disease. Cutaneous blastomycosis is infrequent and tends to be misdiagnosed given its similar presentation to other cutaneous fungal infections and malignancies. A 51-year-old woman presented with a two-month history of disfiguring nasal lesions. Read More

View Article and Full-Text PDF
January 2022

Two Cases of Miliary and Disseminated Coccidioidomycosis Following Glucocorticoid Therapy and Literature Review.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211051928

Kern Medical, Bakersfield, CA, USA.

A 49-year-old man with no significant past medical history received dexamethasone as part of his treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Less than 3 weeks later, the patient developed acute respiratory distress syndrome. Radiological and serological testing led to a diagnosis of acute hypoxic miliary coccidioidomycosis. Read More

View Article and Full-Text PDF

A Fatal Case of Penile Calciphylaxis.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221076275

Kern Medical, Bakersfield, CA, USA.

Calciphylaxis is a rare and serious complication of chronic renal failure characterized by vascular calcium overload. It has a high mortality rate. Penile calciphylaxis is an extremely rare condition of penile necrosis due to calciphylaxis of the penile arterioles. Read More

View Article and Full-Text PDF

Disseminated Coccidioidomycosis: Cutaneous, Soft Tissue, Osseous, and "Shotgun Intraparenchymal" Brain Disease.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221075906

Kern Medical, Bakersfield, CA, USA.

Coccidioidomycosis is a disease found in the southwestern United States and caused by inhalation of arthroconidia of and . Although the disease is most commonly asymptomatic or respiratory, it has a propensity to disseminate to any tissue in the body with the most common being skin, bone, joints, and central nervous system. This case demonstrates the dissemination of coccidioidomycosis to several foci along with a rare form of parenchymal dissemination with an unusual neuroradiological finding. Read More

View Article and Full-Text PDF

Oral Fungal Infections: Past, Present, and Future.

Richard D Cannon

Front Oral Health 2022 3;3:838639. Epub 2022 Feb 3.

Department of Oral Sciences, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand.

Oral fungal infections have afflicted humans for millennia. Hippocrates (. 460-370 BCE) described two cases of oral aphthae associated with severe underlying diseases that could well have been oral candidiasis. Read More

View Article and Full-Text PDF
February 2022

TNFα Blockade Inhibits Both Initial and Continued Control of Pulmonary .

Front Cell Infect Microbiol 2021 31;11:796114. Epub 2022 Jan 31.

Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.

Tumor necrosis factor alpha (TNFα) is a pluripotent cytokine that is important in many infections, though its role in infection remains poorly understood. The need to understand TNFα in infection has increased recently with the widespread use of TNFα inhibitors for a wide variety of autoimmune conditions. Here, we couple the newly developed infection model using strain Cp1038 and C57BL/6 × DBA/2J F1 (B6D2F1) mice. Read More

View Article and Full-Text PDF

Prior Infection with Coccidioidomycosis in Nonhuman Primates and Impact on Simian Immunodeficiency Virus Disease and Vaccine Immunogenicity.

AIDS Res Hum Retroviruses 2022 May 22;38(5):347-349. Epub 2022 Mar 22.

Department of Microbiology, University of Washington, Seattle, Washington, USA.

View Article and Full-Text PDF

Contribution of Biologic Response Modifiers to the Risk of Coccidioidomycosis Severity.

Open Forum Infect Dis 2022 Mar 27;9(3):ofac032. Epub 2022 Jan 27.

Valley Fever Center for Excellence, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA.

Background: The risk of coccidioidomycosis (CM) as a life-threatening respiratory illness or disseminated CM (DCM) increases as much as 150-fold in immunosuppressed patients. The safety of biologic response modifiers (BRMs) as treatment for patients with autoimmune disease (AI) in CM-endemic regions is not well defined. We sought to determine that risk in the Tucson and Phoenix areas. Read More

View Article and Full-Text PDF

Coccidioidal Peritonitis: A Review of 17 Cases.

Open Forum Infect Dis 2022 Mar 19;9(3):ofac017. Epub 2022 Jan 19.

Department of Medicine, Division of Infectious Diseases, Kern Medical, Bakersfield, California, USA.

Coccidioidomycosis is the second most common endemic fungal infection in the United States. Prior descriptions of coccidioidal peritonitis include only single cases. We describe 17 new cases previously unreported from healthcare institutions in California. Read More

View Article and Full-Text PDF