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    Combined Endosonography Reduces Time to Diagnose Pulmonary Coccidioidomycosis.
    J Bronchology Interv Pulmonol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Pulmonary Critical Care Medicine, University of California San Francisco, Fresno, CA.
    Coccidioidomycosis causes significant morbidity in endemic areas. In the absence of sensitive diagnostic serologic testing, clinicians have increasingly relied on lung and lymph node biopsies for diagnosis. Recently, endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been shown to be an excellent sampling method for the diagnosis and staging of lung cancers, especially when combined with endoscopic ultrasound guided fine needle aspiration (EUS-FNA). Read More

    Liposomal Amphotericin B as Monotherapy in Relapsed Coccidioidal Meningitis.
    Mycopathologia 2018 Jan 16. Epub 2018 Jan 16.
    Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, 4150 V Street, Suite G500, Sacramento, CA, 95817, USA.
    Coccidioidal meningitis remains a difficult clinical problem, and despite life-long therapy with triazole antifungals, relapses of disease and medication intolerance occur necessitating salvage treatment. We report two patients with recurrent coccidioidal meningitis who improved following a 2-week course of liposomal amphotericin B monotherapy and discuss potential advantages of this treatment option. Read More

    Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.
    J Med Microbiol 2017 Dec 15. Epub 2017 Dec 15.
    1​Department of Neurosurgery, Duke University Medical Center, NC, USA.
    Purpose: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States.

    Methodology: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012. Read More

    Testing for coccidioidomycosis in emergency departments in Arizona.
    Med Mycol 2017 Dec 8. Epub 2017 Dec 8.
    Arizona Department of Health Services, Phoenix, AZ, USA.
    Testing practices for coccidioidomycosis in the emergency department are poorly understood. We described characteristics of patients tested for coccidioidomycosis in emergency departments in Arizona and examined coccidioidomycosis testing among community-acquired pneumonia (CAP) patients. Emergency department visit records for patients tested for coccidioidomycosis and CAP patients were extracted from the Arizona hospital discharge database. Read More

    Multicenter Clinical Validation of a Cartridge-Based Real-Time PCR System for Detection of Coccidioides spp. in Lower Respiratory Specimens.
    J Clin Microbiol 2017 Dec 6. Epub 2017 Dec 6.
    Laboratory Sciences of Arizona/Sonora Quest Laboratories, Tempe, AZ.
    Available methods for the diagnosis of coccidioidomycosis have significant shortcomings relative to accuracy and timeliness. We retrospectively and prospectively evaluated the diagnostic performance and reproducibility of a new cartridge-based real-time PCR assay for Coccidioides spp. directly in lower respiratory secretions and compared them to today's gold standard fungal culture. Read More

    Recommendations for the management of pulmonary fungal infections in patients with rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Nov-Dec;35(6):1018-1028. Epub 2017 Nov 28.
    Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.
    Often life-threatening pulmonary fungal infections (PFIs) can occur in patients with rheumatoid arthritis (RA) receiving disease-modifying anti-rheumatic drugs (DMARDs). Most of the data concerning PFIs in RA patients come from case reports and retrospective case series. Of the ve most widely described PFIs, Pneumocystis jirovecii pneumonia (PJP) has rarely been seen outside Japan, pulmonary cryptococcosis has been diagnosed in only a small number of patients worldwide, pulmonary coccidioidomycosis has almost only been observed in endemic areas, the limited number of cases of pulmonary histoplasmosis have mainly occurred in the USA, and the rare cases of invasive pulmonary aspergillosis have only been encountered in leukopenic patients. Read More

    Proteogenomic Re-Annotation of Coccidioides posadasii Strain Silveira.
    Proteomics 2018 Jan 14;18(1). Epub 2017 Dec 14.
    School of Life Sciences, Mayo Clinic Collaborative Research Building, Arizona State University, Scottsdale, AZ, USA.
    The aims of this study are to provide protein-based evidence upon which to reannotate the genome of Coccidiodes posadasii, one of two closely related species of Coccidioides, a dimorphic fungal pathogen that causes coccidioidomycosis, also called Valley fever. Proteins present in lysates and filtrates of in vitro grown mycelia and parasitic phase spherules from C. posadasii strain Silveira are analyzed using a GeLC-MS/MS method. Read More

    Relating coccidioidomycosis (valley fever) incidence to soil moisture conditions.
    Geohealth 2017 Apr 25;1:51-63. Epub 2017 Mar 25.
    USDA-ARS-Hydrology and Remote Sensing Laboratory, Beltsville, Maryland, USA.
    Coccidioidomycosis (also called Valley fever) is caused by a soilborne fungus, Coccidioides spp., in arid regions of the southwestern United States. Though some who develop infections from this fungus remain asymptomatic, others develop respiratory disease as a consequence. Read More

    A point-source outbreak of Coccidioidomycosis among a highway construction crew.
    J Occup Environ Hyg 2018 Jan;15(1):57-62
    a School of Public Health, University of California , Berkeley , California.
    Coccidioidomycosis is an infection caused by inhaling spores of the soil fungus Coccidioides immitis (hereafter termed Cocci). Cocci is endemic in certain areas of California. When soil containing the fungus is disturbed, as during earth-moving activities, respirable Cocci spores can become airborne and be inhaled by persons in the vicinity. Read More

    Coccidioidomycosis, immunoglobulin deficiency: safety challenges with CAR T cells therapy for relapsed lymphoma.
    Immunotherapy 2017 Oct;9(13):1061-1066
    Department of Medicine, Division of Hematology, Oncology, Blood and marrow transplantation, University of Arizona, Tucson, AZ 85724, USA.
    Treatment of patients with relapsed or refractory lymphoma may require allogenic hematopoietic stem cell transplant (HSCT), but treatment of post-transplant relapse disease remains very challenging. Donor lymphocyte infusion and blinatumomab have been used with limited success for the treatment of relapse. Initial data on donor-derived CAR T cells has shown this modality to be safe and highly effective in various hematological malignancies. Read More

    Coccidioidomycosis in an Indoor-housed Rhesus Macaque (Macaca mulatta).
    Comp Med 2017 Oct;67(5):452-455
    Integrated Biological Platform Sciences, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania;, Email:
    Coccidioides spp. are saprophytic, dimorphic fungi that are endemic to arid climates, are capable of infecting many species, and result in diverse clinical presentations. An indoor-housed laboratory rhesus macaque presented with weight loss and decreased activity and appetite. Read More

    Immune Reconstitution Inflammatory Syndrome in Patients with AIDS and Disseminated Coccidioidomycosis: A Case Series and Review of the Literature.
    J Int Assoc Provid AIDS Care 2017 Nov/Dec;16(6):540-545. Epub 2017 Sep 14.
    1 Division of Infectious Diseases, University of California San Francisco, Fresno Medical Education Program, Fresno, CA, USA.
    Coccidioidomycosis causes substantial morbidity and mortality in endemic areas, and dissemination is frequent in patients with impaired cellular immunity such as AIDS. Immune reconstitution inflammatory syndrome (IRIS) is paradoxical clinical worsening after initiation of antiretroviral therapy (ART) in a patient with HIV and a simultaneous opportunistic infection (OI). Immune reconstitution inflammatory syndrome has been well described for a host of mycobacterial, viral, and fungal OIs and malignancies such as Kaposi sarcoma. Read More

    A 62-Year-Old Woman With Wheezing, Respiratory Failure, and an Abnormal CT Scan.
    Chest 2017 Sep;152(3):e73-e76
    Department of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Case Presentation: A previously healthy 62-year-old woman was transferred to the ICU from the medical ward with acute bronchospastic respiratory failure requiring intubation and mechanical ventilation. Four weeks before, the patient was vacationing in Arizona and acquired a mildly productive cough as well as mild dyspnea. She presented to an urgent care facility and was diagnosed with community-acquired pneumonia. Read More

    Coccidioidomycosis Involving Lungs and Skin: A Mimicker of Metastatic Disease.
    Am J Dermatopathol 2017 Aug 24. Epub 2017 Aug 24.
    *Department of Pathology, University Hospital "Jose Eleuterio Gonzalez," Monterrey, Mexico; and Departments of †Pathology, and ‡Dermatology, MD Anderson Cancer Center, Houston, TX.
    Coccidioidomycosis is the major systemic mycoses, considered to be 1 of the most infectious fungal diseases. In symptomatic patients, the most common manifestation is pulmonary disease, but many other organs can be affected. Disseminated disease occurs in 1%-5% of all patients affected by coccidioidomycosis and can affect any organ, with the skin, central nervous system, and musculoskeletal system being reported as the most prevalent. Read More

    Enucleation or exenteration in two dogs with previous parotid duct transposition: parotid duct ligation versus reverse parotid duct transposition.
    Vet Ophthalmol 2017 Aug 27. Epub 2017 Aug 27.
    Veterinary Specialty Center of Tucson, Tucson, AZ, USA.
    Two dogs with previous parotid duct transpositions presented with unrelated ocular disease. In both cases, ophthalmic examination revealed the need for enucleation or exenteration. In case 1, systemic coccidioidomycosis was diagnosed with panuveitis and secondary glaucoma of the left eye. Read More

    Spinal Coccidioidomycosis: A Current Review of Diagnosis and Management.
    World Neurosurg 2017 Dec 24;108:69-75. Epub 2017 Aug 24.
    Department of Neurosurgery, Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
    Objective: Coccidioidomycosis is an invasive fungal disease that may present with extrathoracic dissemination. Patients with spinal coccidioidomycosis require unique medical and surgical management. We review the risk factors and clinical presentations, discuss the indications for surgical intervention, and evaluate outcomes and complications after medical and surgical management. Read More

    Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis.
    Curr Infect Dis Rep 2017 Aug 22;19(10):36. Epub 2017 Aug 22.
    University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA.
    Purpose Of Review: The goal of this review is to provide an update on the epidemiology, diagnosis, and treatment of opportunistic fungal infections in patients with human immunodeficiency virus (HIV) infection including Cryptococcus spp., Histoplasma spp., Coccidioides spp. Read More

    Recurrence of cutaneous coccidioidomycosis 6 years after valley fever: A case presentation and literature review.
    Diagn Microbiol Infect Dis 2017 Nov 8;89(3):218-221. Epub 2017 Jul 8.
    Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address:
    Coccidioidomycosis is usually acquired by inhalation of spores of Coccidioides immitis and C. posadasii. The disease ranges from a self-limited acute pneumonia (Valley Fever) to a disseminated disease. Read More

    Diagnosis and Management of Coccidioidomycosis.
    Clin Chest Med 2017 Sep 3;38(3):417-433. Epub 2017 Jun 3.
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, Tucson, AZ 85724, USA. Electronic address:
    Coccidioidomycosis is a leading cause of community-acquired pneumonia within its traditional endemic zone in the Southwestern United States and portions of Mexico and Central and South America. Its incidence has increased dramatically within the endemic region; its presence outside of the region, facilitated by a mobile society, is also now substantial. Although only a fraction of the incident disease progresses beyond subclinical illness, this proportion is large in absolute terms and causes substantial disease burden. Read More

    Notes from the Field: Increase in Coccidioidomycosis - California, 2016.
    MMWR Morb Mortal Wkly Rep 2017 Aug 11;66(31):833-834. Epub 2017 Aug 11.
    Coccidioidomycosis, or Valley Fever, is an infectious disease caused by inhalation of Coccidioides spp. spores (1). This soil-dwelling fungus is endemic in the southwestern United States, with most (97%) U. Read More

    Diagnosis of coccidioidomycosis in a non-endemic area: Inference of the probable geographic area of an infection.
    Rev Iberoam Micol 2017 Oct - Dec;34(4):237-240. Epub 2017 Aug 5.
    Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria No. 3000, México, Cd. Mx. 04510, Mexico. Electronic address:
    Background: Coccidioidomycosis is one of the most important endemic mycoses in Northern Mexico. However, diagnosing this disease can be challenging, particularly in patients who do not reside in endemic areas.

    Case Report: The case of a Mexican HIV+ patient who developed fever, general malaise, a severe cough, and dyspnea during a stay in Acapulco, Guerrero, Mexico, is presented. Read More

    Arthroconidia in lung tissue: an unusual histopathological finding in pulmonary coccidioidomycosis.
    Hum Pathol 2018 Jan 1;71:55-59. Epub 2017 Aug 1.
    Beth Israel Deaconess Medical Center, Department of Pathology, Boston, MA 02215; Harvard Medical School, Boston, MA 02215. Electronic address:
    Coccidioides immitis/posadasii presents in mycelial form with branching hyphae and arthroconidia when cultured in the laboratory. On histopathology, the presence of endospore-containing spherules is considered diagnostic of coccidioidomycosis. Here we report an unusual case of coccidioidomycosis with hyphae and arthroconidia in pulmonary tissue sections. Read More

    Disseminated coccidioidomycosis with molluscum-like lesions, diffuse lymphadenopathy, and splenomegaly in an immunocompetent patient.
    Int Med Case Rep J 2017 20;10:251-254. Epub 2017 Jul 20.
    Texas Tech University Health Sciences Center.
    Coccidioidomycosis is caused by a dimorphic fungus species endemic to the arid and semi-arid regions of the Americas. The species have a terranean habitat producing a primary pulmonary infection by inhalation of arthroconidia. We describe a case of extrapulmonary coccidioidomycosis presenting with extensive lymphadenopathy, splenomegaly, and florid cutaneous lesions. Read More

    Coccidioidomycosis A Cause of Sarcoidosis.
    Open Forum Infect Dis 2017 10;4(3):ofw117. Epub 2017 Jul 10.
    School of Medicine, University of Arizona School of Medicine-Phoenix, Phoenix, Arizona.
    Background: Sarcoidosis is a granulomatous disease of unknown etiology and coccidioidomycosis is a granulomatous fungal infection endemic to the southwestern United States. Clinical observations on patients with sarcoidosis and coccidioidomycosis simultaneously led to the hypothesis that sarcoidosis can be caused by the fungus Coccidioides.

    Methods: Two patients with sarcoidosis and coccidioidomycosis were studied, one prospectively (ie, a patient with sarcoidosis was predicted to develop coccidioidomycosis) and the other retrospectively (ie, a patient with coccidioidomycosis develops sarcoidosis). Read More

    Cellular and Molecular Defects Underlying Invasive Fungal Infections-Revelations from Endemic Mycoses.
    Front Immunol 2017 28;8:735. Epub 2017 Jun 28.
    LKS Faculty of Medicine, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
    The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV), hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs). Dimorphic fungi such as Histoplasma capsulatum, Coccidioides spp. Read More

    Single-center experience of antifungal prophylaxis for coccidioidomycosis in heart transplant recipients within an endemic area.
    Transpl Infect Dis 2017 Oct 7;19(5). Epub 2017 Aug 7.
    Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ, USA.
    In endemic regions, coccidioidomycosis causes substantial morbidity and mortality for patients receiving solid organ transplants. We aimed to demonstrate the effect of antifungal coccidioidal prophylaxis in heart transplant (HT) recipients. We retrospectively reviewed the electronic health records of all patients who received HTs between October 19, 2005, and December 13, 2014. Read More

    Increased Coccidioidomycosis Among Inmates at a California Prison: Initial Investigation in 2005 to 2006.
    J Correct Health Care 2017 Jul 28;23(3):347-352. Epub 2017 Jun 28.
    1 California Department of Public Health, Richmond, CA, USA.
    Since 2005, coccidioidomycosis has increased among inmates at a California prison. Our initial investigation found an incidence of 3,323 cases/100,000 persons. Black race, age ≥41 years, and residence on Yard C were significantly associated with coccidioidomycosis ( p < . Read More

    Assessment of Vulnerability to Coccidioidomycosis in Arizona and California.
    Int J Environ Res Public Health 2017 Jun 23;14(7). Epub 2017 Jun 23.
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
    Coccidioidomycosis is a fungal infection endemic to the southwestern United States, particularly Arizona and California. Its incidence has increased, potentially due in part to the effects of changing climatic variables on fungal growth and spore dissemination. This study aims to quantify the county-level vulnerability to coccidioidomycosis in Arizona and California and to assess the relationships between population vulnerability and climate variability. Read More

    Dust Exposure and Coccidioidomycosis Prevention Among Solar Power Farm Construction Workers in California.
    Am J Public Health 2017 Aug 22;107(8):1296-1303. Epub 2017 Jun 22.
    All of the authors are with California Department of Public Health, Richmond. Jason A. Wilken is also with the Office of Public Health Preparedness and Response, Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, GA.
    Objectives: To investigate if work activities, dust exposure, and protection measures were associated with a 2011 to 2014 coccidioidomycosis outbreak among workers constructing 2 solar farms in California.

    Methods: In 2013, we mailed self-administered questionnaires to employees who were onsite at the solar farms where the outbreak occurred to identify cases of clinical coccidioidomycosis and compare with asymptomatic workers by using multivariate logistic regression.

    Results: When we compared 89 workers with clinical coccidioidomycosis to 325 asymptomatic workers, frequently being in a dust cloud or storm (odds ratio [OR] = 5. Read More

    Disseminated Coccidioidomycosis Presenting as Carcinomatosis Peritonei and Intestinal Coccidioidomycosis in a Patient with HIV.
    Case Rep Gastroenterol 2017 Jan-Apr;11(1):114-119. Epub 2017 Mar 3.
    Texas Tech University Health Sciences Center, Odessa, Texas, USA.
    Coccidioidomycosis (CM) is a fungal infection endemic in southwestern regions of the United States, northwestern regions of Mexico, and some areas of Brazil and Argentina. Clinical presentation varies depending on the extent of the infection and the immune status of the host. The most common presentation ranges from flu-like symptoms to self-limiting pneumonia. Read More

    Coccidioidomycosis: An underreported cause of death-Arizona, 2008-2013.
    Med Mycol 2017 Jun 8. Epub 2017 Jun 8.
    Arizona Department of Health Services, Phoenix, Arizona, USA.
    In Arizona during 1997-2013, coccidioidomycosis increased from 21 to 90 cases/100,000 population, but coccidioidomycosis-associated deaths remained stable at 3-6 deaths/million population. We used the capture-recapture method by using death certificates and hospital discharge data to more fully estimate the total number of coccidioidomycosis-attributable deaths and compared this with published estimates. Death certificates were included if any cause of death included coccidioidomycosis; hospital discharge data deaths were included if any discharge diagnosis included coccidioidomycosis and laboratory confirmation. Read More

    Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection.
    Methods Mol Biol 2017 ;1625:45-64
    Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
    Coccidioidomycosis is a potentially life-threatening mycosis endemic to the Southwestern USA and some arid regions of Central and South America. A vaccine against Coccidioides infection would benefit over 30-million people who reside in or visit the endemic regions. Vaccine candidates against systemic fungal infections come in many forms. Read More

    Divergence in the approach to tumor necrosis factor α-inhibitor recipients with coccidioidomycosis.
    Infection 2017 Aug 2;45(4):539-543. Epub 2017 Jun 2.
    Division of Infectious Diseases, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.
    Background: Tumor necrosis factor α-inhibitors (TNFIs) have been associated with increased risk of certain fungal infections, including coccidioidomycosis. The optimal treatment approach to coccidioidomycosis in TNFI recipients is unknown.

    Methods: We constructed an anonymous, voluntary survey for practicing pulmonary and infectious disease physicians in the state of Arizona regarding approach to TNFI patients with coccidioidomycosis. Read More

    [A case of coccidioidomycosis in Turkey imported from the United States of America].
    Mikrobiyol Bul 2017 Apr;51(2):183-190
    Istanbul University Istanbul Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
    Coccidioidomycosis caused by Coccidioides immitis or Coccidioides posadasii is a rare infectious disease except in endemic regions. In this report the third documented imported case of coccidioidomycosis in Turkey was presented. A thirty-year-old male patient was admitted to our hospital with fever and purulent drainage from his chest tube. Read More

    A Case of Osteomyelitis of the toe caused by Coccidioidomycosis in a 17 year-old with Diabetes Insipidus.
    IDCases 2017 3;9:14-16. Epub 2017 May 3.
    Kaweah Delta Health Care District, 400 West Mineral King Avenue, Visalia, CA 93291, United States.
    We report a case of a 17-year-old male who presented with pain in his right first toe. His pain and swelling had worsened and x-rays of his foot revealed erosive changes of the great toe distal phalanx suggesting possible osteomyelitis. His co-morbidities were morbid obesity and diabetes insipidus. Read More

    A case of a positive coccidioides stool culture in an immunocompetent patient with disseminated coccidioidomycosis.
    IDCases 2017 3;8:89-91. Epub 2017 May 3.
    Department of Medicine, St. Joseph's Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, United States.
    Coccidioidomycosis (CM) is an infection caused by the coccidioides fungus. The spectrum of the disease ranges from a mild upper respiratory illness to severe disseminated infection that could affects the bones, joints, skin, central nervous system, and the gastrointestinal tract. Previous reports of a positive stool culture in the setting of disseminated CM are extremely rare. Read More

    Coccidioidomycosis among persons undergoing lung transplantation in the coccidioidal endemic region.
    Transpl Infect Dis 2017 Aug 22;19(4). Epub 2017 Jun 22.
    Infectious Diseases Division of the Department of Medicine, The University of Arizona College of Medicine, Tucson, AZ, USA.
    Background: Coccidioidomycosis, an endemic fungal infection, is more likely to be symptomatic and severe among those receiving allogeneic transplants. While several case series have been published for various transplanted organs, none has described the incidence and outcomes in those receiving lung transplants within the coccidioidal endemic region.

    Methods: Patients receiving a heart-lung, single-lung, or bilateral-lung transplantation at the University of Arizona between 1985 and 2009 were retrospectively reviewed. Read More

    Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis.
    Clin Infect Dis 2017 Jul;65(2):338-341
    David Geffen School of Medicine, University of California, Los Angeles.
    Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Read More

    Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia.
    Med Mycol Case Rep 2017 Jun 23;16:8-11. Epub 2017 Mar 23.
    Division of Infectious Diseases, Department of Medicine, Banner University Medical Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA.
    Central Nervous System (CNS) vasculitis is the most common life-threatening complication of coccidioidal meningitis. It is manifested by cerebral ischemia, hemorrhage, and infarction. We report a case of CNS vasculitis in a patient receiving chemotherapy and review of the literature on coccidioidal meningitis. Read More

    Ulcerated Lesion of the Tongue as Manifestation of Systemic Coccidioidomycosis.
    Case Rep Med 2017 13;2017:1489501. Epub 2017 Mar 13.
    Department of Oral Pathology, University of Campinas, Piracicaba, SP, Brazil.
    Systemic mycoses and their oral manifestations are very rare. We present a case of a 60-year-old man with an ulcerated lesion on the lateral border of the tongue. Histologic studies revealed a granulomatous fungal infection by Coccidioides immitis. Read More

    Development of an enzyme immunoassay for detection of antibodies against Coccidioides in dogs and other mammalian species.
    PLoS One 2017 5;12(4):e0175081. Epub 2017 Apr 5.
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
    Coccidioides is a soil-dwelling fungus that causes coccidioidomycosis, a disease also known as Valley fever, which affects humans and a variety of animal species. Recent findings of Coccidioides in new, unexpected areas of the United States have demonstrated the need for a better understanding of its geographic distribution. Large serological studies on animals could provide important information on the geographic distribution of this pathogen. Read More

    Oral Fungal Infections: Diagnosis and Management.
    Dent Clin North Am 2017 Apr;61(2):319-349
    Oral & Maxillofacial Surgery, Private Practice: Huntington Beach Oral & Maxillofacial Surgery, 7677 Center Avenue, Suite 206, Huntington Beach, CA 92647, USA; Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA 90806, USA; Oral & Maxillofacial Surgery, Division of Otolaryngology, UCI School of Medicine, 101 The City Drive South, Orange, CA 92868, USA.
    Oral and maxillofacial fungal infections can appear in high-risk patients, including those immunocompromised. This article explores common oral manifestations of fungal infections in the oral cavity as primary lesions or as a result of disseminated disease. By far the most common oral fungal infection experienced in dentistry is oral candidiasis, which is reviewed in depth from simple oral infections to invasive candidiasis. Read More

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