3,578 results match your criteria Coccidioidomycosis


Congenital Coccidioidomycosis: A Case Report and Review of the Literature.

J Pediatric Infect Dis Soc 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Coccidioidomycosis in neonates is rare and the acquisition of disease in this age group is not well understood. Congenital coccidioidomycosis is very rare, usually associated with coccidioidal placentitis. Only a handful of cases of congenital coccidioidomycosis have been described in the literature. Read More

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Disseminated Coccidioidomycosis Presenting as Septic Shock with Multiorgan Failure.

Case Rep Infect Dis 2021 15;2021:8837493. Epub 2021 Apr 15.

Department of Pathology, Texas Tech University Health Sciences Center, 4800 Alberta Avenue, El Paso, TX 79905, USA.

Coccidioidomycosis is a fungal infection caused by and While infections are usually mild, severe disease occurs in immunocompromised patients. Dissemination is associated with severe morbidity and mortality. Because of the tendency of this disease to imitate many diseases, diagnosis may be difficult on presentation. Read More

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Disseminated coccidioidomycosis in an immunocompetent patient.

Int J Infect Dis 2021 Apr 30. Epub 2021 Apr 30.

Division of Infectious Disease, Department of Internal Medicine, Riverside University Health System, Moreno Valley, CA 92555, United States.

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Disseminated coccidioidomycosis in a patient with juvenile idiopathic arthritis receiving infliximab.

Pediatr Rheumatol Online J 2021 May 1;19(1):63. Epub 2021 May 1.

Presbyterian Healthcare Services, New Mexico, Albuquerque, USA.

Background: Coccidioides immitis is a dimorphic fungus endemic to the arid climates of the Southwest United States, Mexico and parts of Central and South America. Human infection occurs through inhalation of spores with less than half of exposures progressing to a symptomatic state that primarily consists of pulmonary manifestations. Disseminated coccidioidomycosis is exceedingly rare, occurring in fewer than 1 % of symptomatic infections. Read More

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Coccidioidomycosis in Allogeneic Stem Cell Transplant Recipients: Case Series and Review of the Literature.

J Fungi (Basel) 2021 Apr 27;7(5). Epub 2021 Apr 27.

Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ 85054, USA.

is an endemic fungus of the Southwest United States that causes the disease coccidioidomycosis. Immunocompromised persons are at increased risk for severe infection and dissemination. One such population is allogeneic bone marrow transplant (allo-HCT) recipients, but accounts of coccidioidal infection in these patients have rarely been documented. Read More

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Recalcitrant facial rash: Cutaneous coccidioidomycosis.

Int J Womens Dermatol 2020 Dec 6;6(5):458-459. Epub 2020 Aug 6.

Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.

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December 2020

Long-Term Infectious Complications of Kidney Transplantation.

Clin J Am Soc Nephrol 2021 Apr 20. Epub 2021 Apr 20.

Division of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio

Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. Opportunistic infections most frequently present in the first 12 months post-transplant and can be modulated on prior exposures and use of prophylaxis. Read More

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The mitochondrial genomes of the human pathogens Coccidioides immitis and C. posadasii.

G3 (Bethesda) 2021 Apr 19. Epub 2021 Apr 19.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, 86011 USA.

Fungal mitochondrial genomes encode genes involved in crucial cellular processes, such as oxidative phosphorylation and mitochondrial translation, and the molecule has been used as a molecular marker for population genetics studies. Coccidioides immitis and C. posadasii are endemic fungal pathogens that cause coccidioidomycosis in arid regions across both American continents. Read More

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Life Cycle Dominates the Volatilome Character of Dimorphic Fungus spp.

mSphere 2021 Apr 14;6(2). Epub 2021 Apr 14.

School of Life Sciences, Arizona State University, Tempe, Arizona, USA

Valley fever (coccidioidomycosis) is an endemic fungal pneumonia of the North and South American deserts. The causative agents of Valley fever are the dimorphic fungi and , which grow as mycelia in the environment and as spherules within the lungs of vulnerable hosts. Current diagnostics for Valley fever are severely lacking due to poor sensitivity and invasiveness, contributing to a 23-day median time to diagnosis, and therefore, new diagnostic tools are needed. Read More

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Disseminated coccidioidomycosis in a patient who is immunocompromised in the setting of immune reconstitution inflammatory syndrome.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Internal Medicine, Howard University Hospital, Washington, DC, USA

Coccidioidomycosis is a systemic fungal infection first described in 1892. More than 95% of annual cases occur in Arizona and California. It is an opportunistic infection (OI) transmitted via inhalation of airborne spores (arthroconidia) and rarely via percutaneous inoculation into a tissue or solid organ transplantation in patients who are immunocompromised and with HIV. Read More

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Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Division of Infectious Diseases, Naval Medical Center, San Diego, CA 92134, USA.

We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection. Read More

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Disseminated Coccidioidomycosis With Orbital Osteomyelitis and Periorbital Abscess.

Ophthalmic Plast Reconstr Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Oculoplastics, Texas Oculoplastics Consultants (TOC) Eye & Face, Austin, Texas School of Medicine, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania Department of Ophthalmology, Dell Medical School, University of Texas, Austin, Texas, U.S.A.

Coccidioidomycosis osteomyelitis involving the orbital bones is exceedingly rare and is often misdiagnosed initially as other inflammatory or infectious conditions. No clear guidelines currently exist regarding appropriate management. The authors present an atypical presentation of disseminated coccidioidomycosis in an immunocompetent child with frontal bone superotemporal orbital rim osteomyelitis and associated periorbital abscess, successfully managed with surgical debridement through an upper eyelid crease incision. Read More

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Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis.

Antimicrob Agents Chemother 2021 Mar 29. Epub 2021 Mar 29.

California Institute for Medical Research, San Jose, CA, USA.

spp. are important pathogens in endemic regions and new treatment options are needed. Isavuconazonium sulfate (ISAVUSULF) and fluconazole (FLU) were evaluated in experimental disseminated coccidioidomycosis to characterize drug exposures associated with efficacy. Read More

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Coccidioidomycosis and COVID-19 Co-Infection, United States, 2020.

Emerg Infect Dis 2021 23;27(5):1266-1273. Epub 2021 Mar 23.

We review the interaction between coronavirus disease (COVID-19) and coccidioidomycosis, a respiratory infection caused by inhalation of Coccidioides fungal spores in dust. We examine risk for co-infection among construction and agricultural workers, incarcerated persons, Black and Latino populations, and persons living in high dust areas. We further identify common risk factors for co-infection, including older age, diabetes, immunosuppression, racial or ethnic minority status, and smoking. Read More

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A global view on fungal infections in humans and animals: infections caused by dimorphic fungi and dermatophytoses.

J Appl Microbiol 2021 Mar 23. Epub 2021 Mar 23.

Faculty of Biological Sciences, Department of Mycology and Genetics, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland.

Fungal infections are still underappreciated and their prevalence is underestimated, which renders them a serious public health problem. Realistic discussions about their distribution, symptoms, and control can improve management and diagnosis and contribute to refinement of preventive actions using currently available tools. This article represents an overview of dermatophytes and endemic fungi that cause infections in humans and animals. Read More

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Cavitary Coccidioidomycosis: Impact of azole antifungal therapy.

Med Mycol 2021 Mar 16. Epub 2021 Mar 16.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic Hospital, Phoenix, Arizona, 85054, USA.

Approximately 5 to 15% of patients with pulmonary coccidioidomycosis subsequently develop pulmonary cavities. These cavities may resolve spontaneously over a number of years; however, some cavities never close, and a small proportion causes complications such as hemorrhage, pneumothorax or empyema. The impact of azole antifungal treatment on coccidioidal cavities has not been studied. Read More

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Less Common Respiratory Conditions: Fungal Respiratory Infections.

FP Essent 2021 Mar;502:23-28

Florida State University College of Medicine Family Medicine Residency Program at BayCare Health System, 1201 1st St S Suite 100A, Winter Haven, FL 33880.

Coccidioidomycosis, histoplasmosis, and aspergillosis are all caused by inhaling a soil fungus. Most patients with coccidioidomycosis, which is endemic to California and Arizona, are asymptomatic, but 40% have influenzalike symptoms that frequently resolve without treatment. Rarely, coccidioidomycosis can disseminate. Read More

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Clinical performance of a point-of-care Coccidioides antibody test in dogs.

J Vet Intern Med 2021 Mar 6;35(2):965-969. Epub 2021 Mar 6.

Department of Medicine and Epidemiology, University of California-Davis, Davis, California, USA.

Background: Point-of-care (POC) Coccidioides antibody assays may provide veterinarians with rapid and accurate diagnostic information.

Objectives: To determine the agreement of a POC lateral flow assay (LFA), sona Coccidioides (IMMY, Norman, Oklahoma) with the current diagnostic standard, the immunodiffusion assay (agar gel immunodiffusion [AGID]; Coccidioidomycosis Serology Laboratory, University of California, Davis, California).

Animals: Forty-eight sera specimens from 48 dogs. Read More

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Disseminated peritoneal coccidioidomycosis in pregnancy following fertility treatment: A case report and literature review.

Case Rep Womens Health 2021 Apr 12;30:e00299. Epub 2021 Feb 12.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of California Los Angeles, USA.

Disseminated peritoneal coccidioidomycosis in the setting of early pregnancy after fertility treatment is rare and can present as a diagnostic challenge. A 39-year-old underwent ovarian stimulation with clomiphene citrate followed by HCG trigger and intrauterine insemination. She developed persistent abdominal pain, ascites and episodes of fever in early pregnancy, and eventually underwent a diagnostic laparoscopy for worsening clinical presentation. Read More

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Using soil survey data to model potential Coccidioides soil habitat and inform Valley fever epidemiology.

PLoS One 2021 19;16(2):e0247263. Epub 2021 Feb 19.

Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Coccidioidomycosis, also known as Valley fever, is a disease that can result in substantial illness and death. It is most common in the southwestern United States and areas of Latin America with arid climates, though reports increasingly suggest its range is wider than previously recognized. The natural habitat of the causative organisms, Coccidioides spp. Read More

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February 2021

Systemic coccidioidomycosis in a llama cria native to Missouri.

J Vet Diagn Invest 2021 May 15;33(3):587-590. Epub 2021 Feb 15.

Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO.

A 3-mo-old male llama was examined because of a 4-wk history of lethargy and ill thrift. Clinical examination revealed subcutaneous masses in the left prescapular and right inguinal regions, mild ataxia, a slight head tilt to the right, and right ear droop. The cria died before clinical workup was complete. Read More

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A Case Report of Coccidioidomycosis in the Renal Parenchyma of Unusual Severity.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:2324709621995331

Department of Medicine, Kern Medical, Bakersfield, CA, USA.

Coccidioidomycosis (CM) is an endemic fungal infection that is found in the Southwestern United States and adjacent areas of Mexico as well as Central and South America. In the United States, 150 000 to 300 000 infections occur annually. The majority are asymptomatic. Read More

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February 2021

Application of laser capture microdissection and PCR sequencing in the diagnosis of spp. infection: A case report and literature review in China.

Emerg Microbes Infect 2021 Dec;10(1):331-341

Department of Dermatology and Venereology, National Clinical Research Center for Skin and Immune Diseases, Research Center for Medical Mycology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Peking University First Hospital, Beijing, People's Republic of China.

Coccidioidomycosis is endemic to California, Arizona, and Mexico. In recent years, the reported cases of coccidioidomycosis have increased in nonendemic regions. Here, we reported a case of imported pulmonary coccidioidomycosis in a Chinese patient. Read More

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December 2021

Health Care Providers' Testing Practices for Coccidioidomycosis and Histoplasmosis in Patients With Community-Acquired Pneumonia-United States, 2020.

Open Forum Infect Dis 2021 Feb 18;8(2):ofab020. Epub 2021 Jan 18.

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Laboratory testing is required to distinguish coccidioidomycosis and histoplasmosis from other types of community-acquired pneumonia (CAP). In this nationwide survey of 1258 health care providers, only 3.7% reported frequently testing CAP patients for coccidioidomycosis and 2. Read More

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February 2021

Clinical and Economic Burden of Valley Fever in Arizona: An Incidence-Based Cost-of-Illness Analysis.

Open Forum Infect Dis 2021 Feb 28;8(2):ofaa623. Epub 2020 Dec 28.

Department of Medicine, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA.

Background: Coccidioidomycosis, ie, Valley fever, is an important fungal infection in the Southwest, with half to two thirds of all cases occurring in Arizona. This endemic respiratory disease can range from primary uncomplicated pneumonia to disseminated infection such as meningitis with chronic pulmonary complications. Valley fever diagnoses have risen over recent years and cause substantial morbidity and economic burden in Arizona. Read More

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February 2021

Thoracic Endemic Fungi in the United States: Importance of Patient Location.

Radiographics 2021 Mar-Apr;41(2):380-398. Epub 2021 Feb 5.

From the Department of Clinical Radiology, University of Missouri-Columbia, 1 Hospital Dr, Columbia, MO 65212 (J.R.K., A.H.); Department of Radiology, University of Southern California, Los Angeles, Calif (L.F.B.); Departments of Diagnostic Radiology (C.F.) and Pathology (D.S.), Oregon Health Sciences & University, Portland, Ore; and Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kan (C.M.W.).

The digitization of radiographic studies along with high-speed transmission of images has formed the basis of teleradiology, which has become an integral component in the workflow of a contemporary radiology practice. It is with this advent and growing utilization of teleradiology that the significance of the source location of images has gained importance. Specifically, the importance of where the patient resides and what endemic fungi occur in that location cannot be underestimated. Read More

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February 2021

Fatal coccidioidomycosis involving the lungs, brain, tongue, and adrenals in a cirrhotic patient. An autopsy case.

IDCases 2021 14;23:e01049. Epub 2021 Jan 14.

Medical Service, Division of Infectious Diseases, South Texas Veterans Healthcare System, 7400 Merton Minter Blvd, San Antonio, TX, 78229, United States.

In this paper, we describe a case of fatal disseminated coccidioidomycosis (CM). The patient was a 44-year old male with a history of cirrhosis who presented with altered mental status, cough, and an enlarged, ulcerated tongue. On evaluation, the patient was found to have coccidioidal infection of the tongue, lungs, and brain. Read More

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January 2021

Coccidioidomycosis in Brazil: Historical Challenges of a Neglected Disease.

J Fungi (Basel) 2021 Jan 27;7(2). Epub 2021 Jan 27.

Department of Pathology, Faculty of Medicine, Federal University of Ceará, Fortaleza 60430-270, Brazil.

Coccidioidomycosis is a deep-seated fungal infection that occurs exclusively in semiarid areas in the Americas. In Brazil, coccidioidomycosis occurs exclusively in rural areas in the northeast region and affects counties that are hit by recurrent droughts, poverty and economic stagnation. Since 1978, approximately 136 cases of the disease have been reported in Brazil, according to scientific publications. Read More

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January 2021

Coccidioidomycosis: a review.

J Investig Med 2021 Feb;69(2):316-323

Infectious Diseases, Kern Medical Center, Bakersfield, California, USA

Coccidioidomycosis is a fungal infection of the Western hemisphere that is endemic to the soil in areas with limited rainfall. Human and animal infections result with inhalation of arthroconidia. Most often, this is an asymptomatic event. Read More

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February 2021

Coccidioidomycosis outbreak among inmate wildland firefighters: California, 2017.

Am J Ind Med 2021 04 23;64(4):266-273. Epub 2021 Jan 23.

California Department of Public Health, Richmond, California, USA.

Background: In California, state prison inmates are employed to fight wildfires, which involves performing soil-disrupting work. Wildfires have become more common, including areas where Coccidioides, the soil-dwelling fungus that causes coccidioidomycosis, proliferates. However, work practices that place wildland firefighters at risk for coccidioidomycosis have not been investigated. Read More

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