9,007 results match your criteria Cocaine-Related Psychiatric Disorders


[Substance abuse and cardiovascular risk: cocaine].

G Ital Cardiol (Rome) 2022 Jun;23(6):444-453

U.O.C. Cardiologia, P.O. San Filippo Neri, ASL Roma 1, Roma.

Cocaine abuse is widely increasing, especially in younger individuals. Cocaine is a major cause of chest pain and acute coronary syndrome and is the leading cause for drug abuse-related visits to emergency departments, most of which are due to cardiovascular complaints. Cocaine use, especially long-term, is associated with an increased risk of all-cause mortality, and with several significant, life-threatening cardiovascular diseases although the multifactorial underlying cellular and molecular pathophysiological mechanisms of acute and chronic cocaine cardiotoxicity are not well established due to limited studies. Read More

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Cannabis and cocaine use, drinking outcomes, and quality of life in general hospital inpatients with alcohol use disorder.

Subst Abus 2022 ;43(1):1225-1230

Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.

While associations between cannabis and cocaine use, and heavy drinking and quality of life (QOL), are well-established in the general population, it is unclear whether they are present in hospital inpatients with alcohol use disorder (AUD). The aim of the study was to assess associations between cannabis and cocaine use and two outcomes [heavy drinking days (HDDs) and QOL] among hospital inpatients with AUD. Hospitalized patients with AUD and at least one past-month HDD participated in this cross-sectional study. Read More

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Correlates of cannabis use disorder in the United States: A comparison of logistic regression, classification trees, and random forests.

J Psychiatr Res 2022 Jul 23;151:590-597. Epub 2022 May 23.

School of Social Work, Boston College, Chestnut Hill, MA, 02467, United States.

Although several recent studies have examined psychosocial and demographic correlates of cannabis use disorder (CUD) in adults, few, if any, recent studies have evaluated the performance of machine learning methods relative to standard logistic regression for identifying correlates of CUD. The present study used pooled data from the 2015-2018 National Survey on Drug Use and Health to evaluate psychosocial and demographic correlates of CUD in adults. In addition, we compared the performance of logistic regression, classification trees, and random forest methods in classifying CUD. Read More

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The Perceptions of Domestic Violence by a Family Member Who Uses Crack or Cocaine: A Secondary Retrospective Cross-Sectional Study.

Int J Environ Res Public Health 2022 05 23;19(10). Epub 2022 May 23.

Programa Recomeço, School Paulista of Nursing, Federal University of São Paulo, Sao Paulo 04024-002, Brazil.

Objective: To evaluate the relationship between crack/cocaine use and domestic violence perpetration from the perspective of substance users' families. A secondary retrospective cross-sectional study, with 3162 family members of crack/cocaine users seeking treatment in the Recomeço Família Programme in São Paulo/Brazil was undertaken. Family members of crack/cocaine users reported that their relatives were more involved in domestic violence such as stealing (money and objects) at home [Odds Ratio Adjusted ORA = 2. Read More

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Outcomes in Patients With Heart Failure Using Cocaine.

Am J Cardiol 2022 Aug 23;176:66-72. Epub 2022 May 23.

Division of Cardiology, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California.

Cocaine is an established cardiovascular toxin, but the impact of cocaine use on clinical outcomes in heart failure (HF) remains unknown. Although nonselective β-blocker use in cocaine users with HF and reduced ejection fraction (HFrEF) appears to be safely tolerated, selective β-blockers have not been evaluated. This study aimed to assess whether cocaine use is associated with worse clinical outcomes in patients with HF and evaluate the safety of β-blocker prescription upon discharge in cocaine users with HFrEF. Read More

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Focal Chronic Meningitis With Lymphoid Follicle-Like Structures Associated With Cocaine-Induced Midline Destructive Lesion: A Case Report.

J Neuropathol Exp Neurol 2022 Jun;81(7):577-580

Department of Anatomical Pathology, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada.

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A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine.

Transl Psychiatry 2022 05 6;12(1):187. Epub 2022 May 6.

Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, United States.

Cocaine use disorder (CUD) patients display heterogenous symptoms and unforeseeable responses to available treatment approaches, highlighting the need to identify objective, accessible biobehavioral signatures to predict clinical trial success in this population. In the present experiments, we employed a task-based behavioral and pharmacogenetic-fMRI approach to address this gap. Craving, an intense desire to take cocaine, can be evoked by exposure to cocaine-associated stimuli which can trigger relapse during attempted recovery. Read More

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An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.

Cell Rep 2022 05;39(5):110775

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92617, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92617, USA; UCI Mind, University of California, Irvine, Irvine, CA 92617, USA. Electronic address:

Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTA→amygdala) for cocaine-induced anxiety but not cocaine reward or sensitization. Our rabies virus-mediated circuit mapping approach reveals a persistent elevation in spontaneous and task-related activity of inhibitory GABAergic cells from the bed nucleus of the stria terminalis (BNST) and downstream VTA→amygdala cells that can be detected even after a single cocaine exposure. Read More

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Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel.

Addict Biol 2022 05;27(3):e13162

Department of Psychology, Binghamton University, Binghamton, New York, USA.

Cocaine self-administration is a complexly determined trait, with a substantial proportion of individual differences being determined by genetic variation. However, the relevant genetic variants that drive heritable differences in cocaine use remain undiscovered. Cocaine intravenous self-administration (IVSA) procedures in laboratory animals provide opportunities to prospectively investigate neurogenetic influences on the acquisition of voluntary cocaine use. Read More

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Unveiling OASIS family as a key player in hypoxia-ischemia cases induced by cocaine using generative adversarial networks.

Sci Rep 2022 04 25;12(1):6734. Epub 2022 Apr 25.

Department of Brain Sciences, DGIST, Daegu, 42988, South Korea.

Repeated cocaine use poses many serious health risks to users. One of the risks is hypoxia and ischemia (HI). To restore the biological system against HI, complex biological mechanisms operate at the gene level. Read More

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Case of Cocaine Induced Coronary and Carotid Artery Dissection.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221089496

Mercyhealth Hospital, Riverside, IL, USA.

Cocaine use has been individually linked to both carotid and coronary artery dissections. However, their simultaneous occurrence has not been previously reported. A 30-year-old man who suffered an acute ischemic stroke and myocardial infarction secondary to acute carotid and coronary artery dissections, respectively, 16 hours after snorting cocaine. Read More

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Oro-Naso-Sino-Orbital-Cutaneous Fistula From Prolonged Cocaine Use.

Ir Med J 2022 02 17;115(2):544. Epub 2022 Feb 17.

ENT Department Tallaght University Hospital, Dublin 24, Ireland.

Presentation We present the case of a 48-year-old man with nasal cellulitis and subsequent oro-naso-sino-orbital-cutaneous fistula from prolonged cocaine use. Diagnosis Initial laboratory investigations reported a raised white cell count (WBC) and C-Reactive Protein (CRP) and subsequently a positive atypical anti-neutrophil cytoplasm antibodies (ANCA) and positive anti-proteinase (PR3). Perihilar lung nodularity on chest imaging raised the possibility of a systemic autoimmune response. Read More

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February 2022

Effects of ketosis on cocaine-induced reinstatement in male mice.

Neurosci Lett 2022 05 5;778:136619. Epub 2022 Apr 5.

Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Valencia, Spain. Electronic address:

In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate the rewarding effects of cocaine, but the negative metabolic consequences rule out the recommendation of using it as a complementary treatment. Thus, the main aim of this study was to evaluate the effects of the KD on cocaine conditioned place preference (CPP) during acquisition, extinction, and reinstatement. Read More

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The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users.

Addict Biol 2022 05;27(3):e13149

Neuroscience Center Zurich, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.

Previous brain imaging studies with chronic cocaine users (CU) using diffusion tensor imaging (DTI) mostly focused on fractional anisotropy to investigate white matter (WM) integrity. However, a quantitative interpretation of fractional anisotropy (FA) alterations is often impeded by the inherent limitations of the underlying tensor model. A more fine-grained measure of WM alterations could be achieved by measuring fibre density (FD). Read More

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Cannabidiol effects on cognition in individuals with cocaine use disorder: Exploratory results from a randomized controlled trial.

Pharmacol Biochem Behav 2022 05 31;216:173376. Epub 2022 Mar 31.

Research Center, Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 St-Denis Street, Montréal, QC H2X 0A9, Canada; Department of Psychiatry and Addiction, Faculty of Medicine, Université de Montréal, 2900 Édouard-Montpetit Boulevard, Montréal, QC H3T 1J4, Canada. Electronic address:

Background: Cocaine use disorder (CUD) is associated with various cognitive deficits that impede patients' functionality, prognosis and therapeutic outcomes. New pharmacological treatments for CUD that could improve cognition are needed.

Objective: To explore whether cannabidiol (CBD) is superior to placebo to improve cognitive functioning in individuals with CUD. Read More

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The Mexican magnetic resonance imaging dataset of patients with cocaine use disorder: SUDMEX CONN.

Sci Data 2022 03 31;9(1):133. Epub 2022 Mar 31.

Instituto de Neurobiología, Universidad Nacional Autónoma de México campus Juriquilla, Querétaro, Mexico.

Cocaine use disorder (CUD) is a substance use disorder (SUD) characterized by compulsion to seek, use and abuse of cocaine, with severe health and economic consequences for the patients, their families and society. Due to the lack of successful treatments and high relapse rate, more research is needed to understand this and other SUD. Here, we present the SUDMEX CONN dataset, a Mexican open dataset of 74 CUD patients (9 female) and matched 64 healthy controls (6 female) that includes demographic, cognitive, clinical, and magnetic resonance imaging (MRI) data. Read More

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Hormonal milieu drives economic demand for cocaine in female rats.

Neuropsychopharmacology 2022 Jul 25;47(8):1484-1492. Epub 2022 Mar 25.

Brain Health Institute, Rutgers University, Piscataway, NJ, 08854, USA.

There are substantial sex differences in drug abuse, and a key feature of cocaine addiction is pathologically high motivation for drug. We investigated the role of ovarian hormones on cocaine demand in female rats using a within-session threshold behavioral economics (BE) procedure, which allows us to compare motivation for drug across hormonal states and sex while controlling for differences in dose and intake. This approach quantifies demand elasticity (α) and free consumption (Q, consumption at null effort) to determine motivation for cocaine. Read More

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Biphasic reward effects are characteristic of both lorcaserin and drugs of abuse: implications for treatment of substance use disorders.

Behav Pharmacol 2022 06 23;33(4):238-248. Epub 2022 Mar 23.

Substance Use Research Laboratory, Research Service, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri.

Lorcaserin is a modestly selective agonist for 2C serotonin receptors (5-HT2CR). Despite early promising data, it recently failed to facilitate cocaine abstinence in patients and has been compared with dopamine antagonist medications (antipsychotics). Here, we review the effects of both classes on drug reinforcement. Read More

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Increased density and antagonistic allosteric interactions in A2AR-D2R heterocomplexes in extinction from cocaine use, lost in cue induced reinstatement of cocaine seeking.

Pharmacol Biochem Behav 2022 04 18;215:173375. Epub 2022 Mar 18.

Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Neurochemical studies were previously performed on the effects of a 10 day extinction learning from cocaine self-administration on D2R and A2AR recognition and D2R Gi/o coupling in the ventral striatum. In the present study biochemical receptor binding and proximity ligation assay were used to study possible changes in the allosteric receptor-receptor interactions and the density of the A2AR-D2R heterocomplexes in the ventral striatum (nucleus accumbens shell) in extinction from cocaine self-administration including cue induced reinstatement of cocaine seeking. A significant and clear-cut reduction of active lever pressing was observed in extinction on day 10 from cocaine use. Read More

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Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.

J Exp Anal Behav 2022 05 17;117(3):457-471. Epub 2022 Mar 17.

Department of Neuroscience, Medical University of South Carolina.

Substance Use Disorders (SUDs) are an impactful problem characterized by chronic relapse and engagement in drug-related behaviors at the expense of non-drug behaviors. Brain regions implicated in drug and non-drug-related behaviors often overlap, complicating investigations of neurobiological mechanisms underlying SUDs. Here we presented a within-subject model for studying self-administration, reinforcer competition, extinction, and cued reinstatement of cocaine- and food-seeking in rats. Read More

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Ca-permeable AMPA receptors set the threshold for retrieval of drug memories.

Mol Psychiatry 2022 Jun 16;27(6):2868-2878. Epub 2022 Mar 16.

Department of Psychiatry and Psychotherapy, University Medical Center, D-37075, Göttingen, Germany.

Frequent relapse prevents the successful treatment of substance use disorders and is triggered in part by retrieval of drug-associated memories. Drug-conditioned behaviours in rodents are reinstated upon drug memory retrieval following re-exposure to cues previously associated with the drug, or the drug itself. Therapies based on mechanistic insights from rodent studies have focused on amnesic procedures of cue-drug associations but with so far limited success. Read More

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Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks.

J Chem Theory Comput 2022 Apr 16;18(4):2703-2719. Epub 2022 Mar 16.

Department of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States.

Cocaine addiction is a psychosocial disorder induced by the chronic use of cocaine and causes a large number of deaths around the world. Despite decades of effort, no drugs have been approved by the Food and Drug Administration (FDA) for the treatment of cocaine dependence. Cocaine dependence is neurological and involves many interacting proteins in the interactome. Read More

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Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self-reported opioid use among a national cohort of patients with HIV.

Alcohol Clin Exp Res 2022 04 16;46(4):600-613. Epub 2022 Mar 16.

Yale School of Medicine, New Haven, Connecticut, USA.

Background: Heavy episodic drinking (HED) is a risk factor for opioid-related overdose and negatively impacts HIV disease progression. Among a national cohort of patients with HIV (PWH), we examined sociodemographic and clinical correlates of concomitant HED and self-reported opioid use.

Methods: We used data collected from 2002 through 2018 from the Veterans Aging Cohort Study, a prospective cohort including PWH in care at eight US Veterans Health Administration sites. Read More

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The Association Between Self-Reported Non-Injection Cocaine Use and Hepatitis C in the United States: An Analysis of the National Health and Nutrition Examination Survey.

J Stud Alcohol Drugs 2022 03;83(2):195-201

Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Objective: Previous studies conducted on hepatitis C virus (HCV) transmission have focused primarily on its transmission among people who inject drugs. However, there is evidence that transmission may also occur through the sharing of contaminated non-injection implements used to consume drugs nasally, orally, or by inhalation. Studies to date have not conclusively established a relationship between these routes of cocaine use and HCV. Read More

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The relationship between craving and insular morphometry in regular cocaine users: Does sex matter?

Addict Biol 2022 03;27(2):e13157

Department of Clinical, Neuro and Developmental Psychology, Vrije University Amsterdam, Amsterdam, The Netherlands.

While it has been suggested that cocaine use and relapse in women is more strongly related to stress-relief craving, whereas cocaine use in men is more strongly related to reward craving, the neural mechanisms that underlie these differences are poorly understood. The aim of this study was to investigate sex-dependent differences in insular morphometry and associations with craving, in a sample of regular cocaine users (CUs) and non-drug using controls (non-CUs). It was hypothesized that insular volume, thickness and surface area would be lower in CU women, compared with CU men and non-CUs. Read More

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Effects of acute and repeated administration of the selective M PAM VU0152099 on cocaine versus food choice in male rats.

Addict Biol 2022 03;27(2):e13145

McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Ligands that stimulate muscarinic acetylcholine receptors 1 and 4 (M , M ) have shown promising effects as putative pharmacotherapy for cocaine use disorder in rodent assays. We have previously shown reductions in cocaine effects with acute M stimulation, as well as long-lasting, delayed reductions in cocaine taking and cocaine seeking with combined M /M receptor stimulation or with M stimulation alone. M stimulation opposes dopaminergic signalling acutely, but direct dopamine receptor antagonists have proved unhelpful in managing cocaine use disorder because they lose efficacy with long-term administration. Read More

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Moderation of buprenorphine therapy for cocaine dependence efficacy by variation of the Prodynorphin gene.

Eur J Clin Pharmacol 2022 Jun 26;78(6):965-973. Epub 2022 Feb 26.

The Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 2002 Holcombe Blvd., Research 151, Building 110, Suite 227, Houston, TX, 77030, USA.

Purpose: The aim of this secondary analysis was to identify prodynorphin (PDYN) genetic markers moderating the therapeutic response to treatment of cocaine dependence with buprenorphine/naloxone (Suboxone®; BUP).

Methods: Cocaine-dependent participants (N = 302) were randomly assigned to a platform of injectable, extended-release naltrexone (XR-NTX) and one of three daily medication arms: 4 mg BUP (BUP4), 16 mg BUP (BUP16), or placebo (PLB) for 8 weeks (Parent Trial Registration: Protocol ID: NIDA-CTN-0048, Clinical Trials.gov ID: NCT01402492). Read More

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Regulation of cocaine-related behaviours by estrogen and progesterone.

Neurosci Biobehav Rev 2022 04 19;135:104584. Epub 2022 Feb 19.

Department of Psychology, University of Guelph, Guelph, ON, Canada; Collaborative Neurosciences Graduate Program, University of Guelph, Guelph, ON, Canada. Electronic address:

Women are more sensitive to cocaine craving elicited by stimuli associated with relapse. Ovarian hormones modulate cocaine craving and may therefore function as risk factors or therapeutic agents for the development and treatment of cocaine use disorder, respectively. We review herein the neuropharmacological effects of the steroid hormones 17ß-estradiol, progesterone, and allopregnanolone, a progesterone metabolite, in relation to their effects on cocaine-induced locomotion, behavioural sensitization, conditioned place preference, and reinstatement of cocaine seeking. Read More

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