41,418 results match your criteria Cocaine


Substance type moderates the longitudinal association between depression and substance use from pre-treatment through a 1-year follow-up.

Drug Alcohol Depend 2019 Feb 5;197:87-94. Epub 2019 Feb 5.

Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, 235 E. Cameron Avenue, Chapel Hill, NC 27514 USA. Electronic address:

Background: Research examining directionality of the relationship between depressive symptoms and substance use following treatment entry is limited. Furthermore, substances differ in their neurobiological effects on mood. The relationship between depression and substance use following treatment entry may be moderated by dependence on specific substances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2019.01.002DOI Listing
February 2019

The effects of Pavlovian cue extinction and ceftriaxone on cocaine relapse after abstinence.

Drug Alcohol Depend 2019 Feb 13;197:83-86. Epub 2019 Feb 13.

Department of Psychology, University of Florida, Gainesville, FL, 32603, USA. Electronic address:

Background: Cocaine use disorder is a significant public health problem and currently no medications are FDA-approved to reduce cocaine relapse. Drug-associated cues are reported to elicit craving and cocaine-seeking in humans. Repeated, non-reinforced presentations of drug-associated cues (cue extinction) have been proposed to reduce the ability of such cues to prompt drug-seeking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2019.01.005DOI Listing
February 2019

The detection of drugs of abuse and pharmaceuticals in drinking water using solid-phase extraction and liquid chromatography-mass spectrometry.

Chemosphere 2019 Feb 14;223:438-447. Epub 2019 Feb 14.

Forensic and Investigative Sciences Research Group, Department of Biomedical and Forensic Sciences, Faculty of Science and Technology, Anglia Ruskin University, Cambridge, CB1 1PT, United Kingdom. Electronic address:

Pharmaceuticals and drugs of abuse including novel psychoactive substances (NPS) are emerging as newer contaminants in the aquatic environment. The presence of such pollutants has implications on the environment as well as public health and therefore their identification is important when monitoring water quality. This research presents a new method for the simultaneous detection of 20 drugs of abuse and pharmaceuticals in drinking water, including 15 NPS, three traditional illicit drugs and two antidepressants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.040DOI Listing
February 2019

Attention-Deficit Hyperactivity Disorder Symptom Status in a Mixed Gender Population of Opioid-Maintained Prison Inmates.

Eur Addict Res 2019 Feb 18;25(2):80-92. Epub 2019 Feb 18.

Department for Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Objective: Attention-deficit hyperactivity disorder (ADHD) often coincides with substance abuse and delinquency. A sample of opioid-maintained inmates was assessed for symptoms of ADHD, substance abuse history, types of offense, psychiatric comorbidities, and psychopharmacological treatment using a standardized battery of instruments.

Method: Adult inmates (n = 133, mean age 35. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496351DOI Listing
February 2019

Illicit substance use after release from prison among formerly incarcerated primary care patients: a cross-sectional study.

Addict Sci Clin Pract 2019 Feb 19;14(1). Epub 2019 Feb 19.

Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

Background: More than 80% of people in jail or prison report having used illicit substances in their lifetimes. After release from incarceration, resumption of substance use carries risks, including parole revocation, exacerbation of mental health conditions, transmission of infectious diseases, and drug overdose.

Methods: This cross-sectional study used baseline data from the Transitions Clinic Network (TCN, www. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13722-019-0136-6DOI Listing
February 2019

The driving brain: the CNS in the pathogenesis and treatment of anorexia-cachexia syndrome.

Expert Rev Endocrinol Metab 2009 Mar;4(2):153-160

g Department of Clinical Medicine, Sapienza University of Rome, viale dell'Università 37, 00185 Rome, Italy.

Over the past few years, medical care has dramatically improved knowledge of the pathogenic mechanisms of diseases, leading to more effective therapies as well as improved technologies, yielded to enhance survival for diseases that, just a few decades ago, would have been considered lethal. Unfortunately, not all diseases can be completely defeated. In many circumstances, therapies may delay the progression of the disease, leading to improved survival but bringing new issues to light. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17446651.4.2.153DOI Listing

The influence of sex and estrous cyclicity on cocaine and remifentanil demand in rats.

Addict Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychology, University of Kentucky, Lexington, KY, USA.

The application of behavioral economic demand theory in addiction science has proved useful for evaluating individual characteristics underlying abuse liability. Two factors that have received comparably little attention within this literature are sex and gonadal hormones. We determined cocaine and remifentanil demand in male and female rats using a within-session procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12716DOI Listing
February 2019

An overview of Bayesian reasoning in the analysis of delay-discounting data.

J Exp Anal Behav 2019 Feb 19. Epub 2019 Feb 19.

Addiction Recovery Research Center, Virginia Tech Carilion Research Institute.

Statistical inference (including interval estimation and model selection) is increasingly used in the analysis of behavioral data. As with many other fields, statistical approaches for these analyses traditionally use classical (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jeab.504DOI Listing
February 2019

Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse.

Addict Biol 2019 Feb 18. Epub 2019 Feb 18.

National Research Council of Italy, Institute of Neuroscience, Italy.

Epidemiological studies have shown that people who begin experimenting drugs of abuse during adolescence are more likely to develop substance use disorders, and the earliest is the beginning of their use, the greatest is the likelihood to become dependent. Understanding the neurobiological changes increasing adolescent vulnerability to drug use is becoming imperative. Although all neurotransmitter systems undergo relevant developmental changes, dopamine system is of particular interest, given its role in a variety of functions related to reward, motivation, and decision making. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12721DOI Listing
February 2019

[Characterization of smoked cocaine substance users in treatment for drug abuse in Buenos Aires, Argentina].

Vertex 2018 Jul;XXIX(140):245-251

Consejo Nacional de Investigaciones Científicas y Técnicas, con sede en el Instituto de Investigaciones Gino Germani, Facultad de Ciencias Sociales, UBA.

In this paper, we present the results of a survey that was part of a regional project on smokable cocaine substance developed in Argentina, Brazil, Chile, Paraguay and Uruguay. We analyze the characteristics of users of smoked cocaine who attend treatment centers or institutions in Buenos Aires (Argentina) that provide support and care, but not a formal treatment for drug abuse. We analyze their sociodemographic characteristics, their social supports, their health, their drug use patterns (age of onset, substances, use frequency and procedures of administration) and their history of treatment. Read More

View Article

Download full-text PDF

Source

A case off TTP temporally associated with cocaine use: Implications for treatment of suspected DITMA.

J Clin Apher 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, West Virginia University Hospital, Morgantown, West Virginia.

Thrombotic microangiopathies are rare diseases associated with significant morbidity and mortality. The treatment of thrombotic thrombocytopenic purpura (TTP) and drug-induced thrombotic microangiopathy (DITMA) remains a diagnostic dilemma as they present similarly but respond differently to standard treatment with plasma exchange. TTP is a deficiency of a disintegrin and metalloprotease with thrombospondin type 1 motif 13 resulting in von Willebrand factor aggregates. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21687
Publisher Site
http://dx.doi.org/10.1002/jca.21687DOI Listing
February 2019
3 Reads

Pitolisant and intravenous cocaine self-administration in mice.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Département de Psychologie, Cognition et Comportement, Université de Liège, Place des Orateurs, 2/B-32, Liège, Belgium.

Pitolisant, a selective inverse agonist for the histamine H3 receptor, is a new treatment for adults suffering from narcolepsy. Numerous studies have shown that striatal H3 receptors can modulate the activity of the dopamine mesolimbic system, a pathway that plays a crucial role in drug addiction. Therefore, it is important to guarantee that pitolisant has no abuse potential and does not potentiate the behavioral effects of psychostimulants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2019.02.019DOI Listing
February 2019

Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder.

Transl Psychiatry 2019 Feb 15;9(1):93. Epub 2019 Feb 15.

Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892-1013, USA.

The response to drugs of abuse is affected by expectation, which is modulated in part by dopamine (DA), which encodes for a reward prediction error. Here we assessed the effect of expectation on methylphenidate (MP)-induced striatal DA changes in 23 participants with an active cocaine use disorder (CUD) and 23 healthy controls (HC) using [C]raclopride and PET both after placebo (PL) and after MP (0.5 mg/kg, i. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41398-019-0421-x
Publisher Site
http://dx.doi.org/10.1038/s41398-019-0421-xDOI Listing
February 2019
6 Reads

Hospital Variation in Child Protection Reports of Substance Exposed Infants.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, University of Washington School of Public Health, Seattle, WA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA; Harborview Injury Prevention & Research Center, University of Washington, Seattle, WA.

Objective: To examine whether hospital-level factors contribute to discrepancies in reporting to Child Protective Services (CPS) of infants diagnosed with prenatal substance exposure.

Study Design: We used a linked dataset of birth, hospital, and CPS records using diagnostic codes (International Classification of Diseases, Ninth Revision) to identify infants diagnosed with prenatal substance exposure. Using multilevel models, we examined hospital-level and individual birth-level factors in relation to a report to CPS among those infants prenatally exposed to substances. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223476193000
Publisher Site
http://dx.doi.org/10.1016/j.jpeds.2018.12.065DOI Listing
February 2019
3 Reads

Association between Drug Use and In-Hospital Outcomes after Infrainguinal Bypass for Peripheral Arterial Occlusive Disease.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, MD; Department of Surgery, University of California San Diego, La Jolla, CA. Electronic address:

Objective: Drug abuse may affect lower extremity vessels due to ischemia following intra-arterial injections, vasospasm, arterial and venous pseudoaneurysms, arteriovenous fistulae, vasculitis and complicated abscesses. Little is known about the outcomes of Lower Extremity Bypass (LEB) for peripheral arteries disease (PAD) in patients with a history of drug abuse disorder. The aim of this study is to evaluate the outcomes of LEB in this patient population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.12.070DOI Listing
February 2019
2 Reads

MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats.

Neuropharmacology 2019 Feb 12. Epub 2019 Feb 12.

School of Biological Sciences, Centre for Biodiscovery, Victoria University of Wellington, Wellington, New Zealand. Electronic address:

Kappa opioid receptor (KOPr) agonists have preclinical anti-cocaine and antinociceptive effects. However, adverse effects including dysphoria, aversion, sedation, anxiety and depression limit their clinical development. MP1104, an analogue of 3-iodobenzoyl naltrexamine, is a potent dual agonist at KOPr and delta opioid receptor (DOPr), with full agonist efficacy at both these receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2019.02.010DOI Listing
February 2019
1 Read

Perioperative Management for the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia.

J Oral Maxillofac Surg 2019 Jan 18. Epub 2019 Jan 18.

Program Director and Chairperson, Department of Oral and Maxillofacial Surgery, Brookdale University Hospital and Medical Center, Brooklyn, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2019.01.016DOI Listing
January 2019

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019
1 Read

Can acute stress be fatal? A systematic cross-disciplinary review.

Stress 2019 Feb 15:1-9. Epub 2019 Feb 15.

b Psychiatric Centre Copenhagen, Department O, Rigshospitalet , Copenhagen University Hospital ,  Copenhagen , Denmark.

In this review it is discussed if acute stress can be fatal. The review is based on literature searches on PubMed, PsycINFO as well as Web of Science. Literature concerning the conditions excited delirium syndrome (ExDS), malignant catatonia, takotsubo cardiomyopathy (TCM), and capture myopathy (CM) is reviewed and compared. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10253890.2018.1
Publisher Site
http://dx.doi.org/10.1080/10253890.2018.1561847DOI Listing
February 2019
3 Reads

Estradiol-Induced Potentiation of Dopamine Release in Dorsal Striatum Following Amphetamine Administration Requires Estradiol Receptors and mGlu5.

eNeuro 2019 Jan-Feb;6(1). Epub 2019 Feb 13.

Molecular and Behavioral Neuroscience Institute.

Estradiol potentiates behavioral sensitization to cocaine as well as self-administration of cocaine and other drugs of abuse in female rodents. Furthermore, stimulated dopamine (DA) in the dorsolateral striatum (DLS) is rapidly enhanced by estradiol, and it is hypothesized that this enhanced DA release mediates the more rapid escalation of drug taking seen in females, compared with males. The mechanisms mediating the effect of estradiol to enhance stimulated DA release were investigated in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/ENEURO.0446-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374122PMC
February 2019

Prescription opioid misuse among middle-aged and older adults in the United States, 2015-2016.

Prev Med 2019 Feb 11;121:94-98. Epub 2019 Feb 11.

Center for Drug Use and HIV/HCV Research, NYU College of Global Public Health, 665 Broadway, 11th Floor, New York, NY 10012, United States of America; New York University Langone Medical Center, Department of Population Health, 550 First Avenue, New York, NY 10016, United States of America.

Adults ≥50 years of age have high rates of prescription opioid use. The purpose of this study is to estimate the prevalence and correlates of prescription opioid misuse among middle-aged and older adults in the United States who use prescription opioids. Data from adults age ≥ 50 from the two most recent cohorts (2015 and 2016) of the National Survey of Drug Use and Health were examined (N = 17,608). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ypmed.2019.02.018DOI Listing
February 2019
2 Reads

Increased picture-word interference in chronic and recreational users of cocaine.

Hum Psychopharmacol 2019 Feb 14:e2689. Epub 2019 Feb 14.

Mind, Brain and Behavior Research Center (CIMCYC), Department of Experimental Psychology, University of Granada, Granada, Spain.

Objective: The correct production of speech depends on the effective use of inhibitory control. Cocaine abuse has been linked to impaired inhibition in the verbal and nonverbal domains. The aim of this study was to evaluate the possible impairment of the inhibitory control process engaged in the production of language among chronic cocaine users, both in rehabilitation and recreational contexts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hup.2689DOI Listing
February 2019

Never Mind Its Past Cocaine and Celery: Celerina's Alcohol "Treated" Alcoholism.

Authors:

Anesthesiology 2019 Mar;130(3):363

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ALN.0000000000002650DOI Listing
March 2019
1 Read

Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study.

Front Behav Neurosci 2019 30;13. Epub 2019 Jan 30.

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Recent animal models of alcohol use disorder (AUD) are centered in capturing individual vulnerability differences in disease progression. Here, we used genetically selected Marchigian Sardinian alcohol-preferring (msP) and Wistars rats to apply a multidimensional model of AUD adapted from a previously described DSM-IV/DSM-5 multisymptomatic cocaine addiction model. As proof of concept, we hypothesized that msP rats, genetically selected for excessive drinking, would be more prone to develop dependence-like behavior compared to Wistars. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnbeh.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364792PMC
January 2019
1 Read

Anxiety, the chicken or the egg of addiction: targeting G9a for the treatment of comorbid anxiety and cocaine addiction.

Neuropsychopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Pediatric Neurology, Pediatrics, Weill Cornell Medicine, New York, NY, 10065, USA.

Treating cocaine addiction is a major challenge and currently no FDA approved pharmacotherapies exist. One complicating factor is a high rate of comorbidity between cocaine and neuropsychiatric conditions such as anxiety. The relationship between anxiety symptoms and cocaine addiction is complicated; anxiety can be both a predisposing factor and a consequence of cocaine use as anxiety symptoms often emerge during drug use and withdrawal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-019-0329-4DOI Listing
February 2019

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Sci Rep 2019 Feb 12;9(1):1841. Epub 2019 Feb 12.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

The peptide hormone acyl-ghrelin and its receptor, GHSR, represent intriguing therapeutic targets due to their actions in metabolic homeostasis and reward activity. However, this pleotropic activity makes it difficult to intervene in this system without inducing unwanted effects. Thus, it is desirable to identify passive and active regulatory mechanisms that allow differentiation between functional domains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-38549-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372697PMC
February 2019
1 Read

Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration.

Addict Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands.

Excessive use of cocaine is known to induce changes in brain white and gray matter. It is unknown whether the extent of these changes is related to individual differences in vulnerability to cocaine addiction. One factor increasing vulnerability involves reduced expression of the serotonin transporter (5-HTT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12722DOI Listing
February 2019
1 Read

Viral vector-mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine-related behaviors and hallmarks of programmed cell death.

J Neurochem 2019 Feb 12. Epub 2019 Feb 12.

Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, 75005, Paris, France.

Cre/loxP recombination is a widely used approach to study gene function in vivo, using mice models expressing the Cre recombinase under the control of specific promoters or through viral delivery of Cre-expressing constructs. A profuse literature on transgenic mouse lines points out the deleterious effects of Cre expression in various cell types and tissues, presumably by acting on illegitimate loxP-like sites present in the genome. However, most studies reporting the consequences of Cre-lox gene invalidation often omit adequate controls to exclude the potential toxic effects of Cre, compromising the interpretation of data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.14684DOI Listing
February 2019
2 Reads

Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.

Brain Struct Funct 2019 Feb 12. Epub 2019 Feb 12.

Department of Physiology and Pharmacology, Wake Forest School of Medicine, Center for the Neurobiology of Addiction Treatment, One Medical Center Boulevard, Winston-Salem, NC, 27157-1083, USA.

It has been shown that exposure to cocaine can result in neuroinflammatory responses. Microglia, the resident CNS immune cells, undergo a transition to an activated state when challenged. In rodents, and possibly humans, cocaine exposure activates microglia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00429-019-01846-4DOI Listing
February 2019

Sex-Specific Gene Expression in the Mouse Nucleus Accumbens Before and After Cocaine Exposure.

J Endocr Soc 2019 Feb 14;3(2):468-487. Epub 2019 Jan 14.

Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut.

The nucleus accumbens plays a major role in the response of mammals to cocaine. In animal models and human studies, the addictive effects of cocaine and relapse probability have been shown to be greater in females. Sex-specific differential expression of key transcripts at baseline and after prolonged withdrawal could underlie these differences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/js.2018-00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364626PMC
February 2019

G protein βγ subunits play a critical role in the actions of amphetamine.

Transl Psychiatry 2019 Feb 11;9(1):81. Epub 2019 Feb 11.

Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA.

Abnormal levels of dopamine (DA) are thought to contribute to several neurological and psychiatric disorders including drug addiction. Extracellular DA levels are regulated primarily via reuptake by the DA transporter (DAT). Amphetamine, a potent psychostimulant, increases extracellular DA by inducing efflux through DAT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-019-0387-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370791PMC
February 2019

The impact of temperature on the transformation of illicit drug biomarkers in wastewater.

Sci Total Environ 2018 Dec 23;644:1612-1616. Epub 2018 Jul 23.

Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet 115, 2800 Kongens Lyngby, Denmark; Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address:

Temperature is one of the key factors, influencing the transformation kinetics of organic chemicals. In the context of wastewater-based epidemiology, however, temperature differences among sewer catchments and within the same catchment (due to, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.06.307DOI Listing
December 2018
1 Read

Associations between drug use patterns and viral load suppression among HIV-positive individuals who use support services in New York City.

Drug Alcohol Depend 2019 Jan 15;197:15-21. Epub 2019 Jan 15.

New York City Department of Health and Mental Hygiene, Bureau of HIV/AIDS Prevention and Control, 42-09 28th Street, Queens, NY, 11101-4132, USA.

Background: Drug use (DU) represents a significant barrier to maintaining physical health among people living with HIV (PLWH). Few studies, however, have examined the relationship between DU over time and HIV treatment outcomes. Such studies are needed because an individual's risk of poor health outcomes may vary with their DU behaviors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2018.12.015DOI Listing
January 2019

Dopamine Neurotransmission in the Ventral Tegmental Area Promotes Active Forgetting of Cocaine-Associated Memory.

Mol Neurobiol 2019 Feb 9. Epub 2019 Feb 9.

Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.

Dopamine (DA) neurons in the ventral tegmental area (VTA) are well-known components of the brain involved in reward-related behaviors and participate in the generation of new memories. Much attention has been focused to understand how DA neurons integrate a diversity of afferent signals with local excitatory and inhibitory influences regulated by somatodendritic release of dopamine. However, the mechanisms that actively forget rewarding information are still terra incognita. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-019-1516-3DOI Listing
February 2019

7,8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the BDNF-TrkB pathway.

Biochem Pharmacol 2019 Feb 6;163:84-93. Epub 2019 Feb 6.

Department of Pharmacology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. Electronic address:

3,4-Methylenedioxypyrovalerone (MDPV) acts as a dopamine transporter blocker and exerts powerful psychostimulant effects. In this study we aimed to investigate the bidirectional cross-sensitization between MDPV and cocaine, as well as to evaluate the role of the BDNF-TrkB signaling pathway in the development of locomotor sensitization to both drugs. Mice were treated with MDPV (1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2019.02.004DOI Listing
February 2019

Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

In drug addiction, environmental stimuli previously associated with cocaine use readily elicit cocaine-associated memories, which persist long after abstinence and trigger cocaine craving and consumption. Although previous studies suggest that the medial prefrontal cortex (mPFC) is involved in the expression of cocaine-addictive behaviors, it remains unclear whether excitatory and inhibitory neurons in the mPFC are causally related to the formation and retrieval of cocaine-associated memories. To address this issue, we used the designer receptors exclusively activated by designer drugs (DREADD) technology combined with a cocaine-induced conditioned place preference (CPP) paradigm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12723DOI Listing
February 2019

Cocaine'omics: Genome-wide and transcriptome-wide analyses provide biological insight into cocaine use and dependence.

Addict Biol 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.

We investigated the genetic and molecular architecture of cocaine dependence (CD) and cocaine use by integrating genome-/transcriptome-wide analyses. To prioritize candidates for follow-up investigation, we also sought to translate gene expression findings across species. Using data from the largest genome-wide association study (GWAS) of CD to date (n = 3176, 74% with CD), we assessed genomic heritability, gene-based associations, and tissue enrichment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12719DOI Listing
February 2019

Fasting Upregulates , and Without Increasing Ghrelin Levels in Zebrafish () Larvae.

Front Physiol 2018 24;9:1901. Epub 2019 Jan 24.

Laboratorio de Hormonas y Receptores INTA, Universidad de Chile, Santiago, Chile.

Food intake in fish and mammals is orchestrated by hypothalamic crosstalk between orexigenic (food intake stimulation) and anorexigenic (food intake inhibition) signals. Some of these signals are released by peripheral tissues that are associated with energy homeostasis or nutrient availability. During the fish larva stage, orexigenic stimulation plays a critical role in individual viability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.01901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353792PMC
January 2019

Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers.

Sci Rep 2019 Feb 7;9(1):1534. Epub 2019 Feb 7.

Wayne State University School of Medicine, Department of Pharmacology, Detroit, MI, 48201, USA.

Opioid abuse is now the most common cause of accidental death in the US. Although opioids and most other drugs of abuse acutely increase signaling mediated by midbrain dopamine (DA)-synthesizing neurons, little is known about long-lasting changes in DA cells that may contribute to continued opioid abuse, craving, and relapse. A better understanding of the molecular and cellular bases of opioid abuse could lead to advancements in therapeutics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-38209-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367337PMC
February 2019
1 Read

Heart failure and adverse heart failure outcomes among persons living with HIV in a US tertiary medical center.

Am Heart J 2019 Jan 11;210:39-48. Epub 2019 Jan 11.

Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

Background: Persons living with HIV (PLHIV) have an increased risk of heart failure (HF). However, little is known about outcomes among PLHIV with HF. The study aim was to compare HF outcomes among PLHIV with HF versus individuals without HIV with HF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ahj.2019.01.002DOI Listing
January 2019
1 Read
4.463 Impact Factor

A ketogenic diet diminishes behavioral responses to cocaine in young adult male and female rats.

Neuropharmacology 2019 Feb 4;149:27-34. Epub 2019 Feb 4.

Neuroscience Program, Hartford, CT, 06106, USA; Department of Psychology, Trinity College, Hartford, CT, 06106, USA. Electronic address:

Ketogenic diets (KDs) are high fat, low carbohydrate formulations traditionally used to treat epilepsy; more recently, KDs have shown promise for a wide range of other neurological disorders. Drug addiction studies suggest that repeated exposure to drugs of abuse, including cocaine, results in a suite of neurobiological changes that includes neuroinflammation, decreased glucose metabolism, and disordered neurotransmission. Given that KDs positively regulate these factors, we addressed whether administration of a KD has potential as a novel therapy for drug addiction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2019.02.001DOI Listing
February 2019

Cocaine Use and Pre-Exposure Prophylaxis: Adherence, Care Engagement, and Kidney Function.

J Acquir Immune Defic Syndr 2019 Jan 25. Epub 2019 Jan 25.

Department of Public Health Sciences, University of Miami, FL.

Background: Concomitant use of cocaine and HIV pre-exposure prophylaxis (PrEP) raises important clinical questions around adherence, retention in care, and renal toxicity.

Methods: We assessed the associations of confirmed cocaine use with PrEP adherence (both ascertained via objective measures), care engagement, and renal function in the iPrEx open label extension. Cocaine use was measured in scalp hair samples and categorized as: light (500-3,000 pg/mg) and moderate to heavy (>3,000 pg/mg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000001972DOI Listing
January 2019
2 Reads

The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice.

Addict Biol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.

An increasing number of reports have provided crucial evidence that epigenetic modifications, such as DNA methylation, may be involved in initiating and establishing psychostimulant-induced stable changes at the cellular level by coordinating the expression of gene networks, which then manifests as long-term behavioral changes. In this study, we evaluated the enzyme activity of DNA methyltransferases (DNMTs) after cocaine treatment and during withdrawal. Furthermore, we studied how genetic or pharmacological inhibition of DNMTs in mouse nucleus accumbens (NAc) affects the induction and expression of cocaine-induced behavioral sensitization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/adb.12720DOI Listing
February 2019

Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement.

Neuropsychopharmacology 2019 Jan 23. Epub 2019 Jan 23.

Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

While preclinical work has aimed to outline the neural mechanisms of drug addiction, it has overwhelmingly focused on male subjects. There has been a push in recent years to incorporate females into existing addiction models; however, males and females often have different behavioral strategies, making it important to not only include females, but to develop models that assess the factors that comprise female drug addiction. Traditional self-administration models often include light or tone cues that serve as discriminative stimuli and/or consequent stimuli, making it nearly impossible to disentangle the effects of cue learning, the cues themselves, and acute effects of psychostimulant drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-019-0320-0DOI Listing
January 2019
2 Reads

Marijuana smoking and markers of testicular function among men from a fertility centre.

Hum Reprod 2019 Feb 6. Epub 2019 Feb 6.

Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Study Question: Is marijuana smoking associated with semen quality, sperm DNA integrity or serum concentrations of reproductive hormones among subfertile men?

Summary Answer: Men who had ever smoked marijuana had higher sperm concentration and count and lower serum FSH concentrations than men who had never smoked marijuana; no differences were observed between current and past marijuana smokers.

What Is Known Already: Studies of marijuana abuse in humans and animal models of exposure to marijuana suggest that marijuana smoking adversely impacts spermatogenesis. Data is less clear for moderate consumption levels and multiple studies have found higher serum testosterone concentrations among marijuana consumers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/humrep/dez002DOI Listing
February 2019

Psychopharmacology: neuroimmune signaling in psychiatric disease-developing vaccines against abused drugs using toll-like receptor agonists.

Psychopharmacology (Berl) 2019 Feb 6. Epub 2019 Feb 6.

Department of Psychiatry, Baylor College of Medicine, 1977 Butler Blvd, Suite E4.207, Houston, TX, 77030, USA.

Rationale: Since substance use disorders have few or no effective pharmacotherapies, researchers have developed vaccines as immune-therapies against nicotine, cocaine, methamphetamine, and opioids including fentanyl.

Objectives: We focus on enhancing antibody (AB) production through stimulation of toll-like receptor-5 (TLR5) during active vaccination. The stimulating adjuvant is Entolimod, a novel protein derivative of flagellin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-019-5176-9DOI Listing
February 2019
2 Reads