3,971 results match your criteria Cluster Headache


Sphenopalatine Ganglion Block and Radiofrequency Ablation: Technical Notes and Efficacy.

Ochsner J 2019 ;19(1):32-37

Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA.

Sphenopalatine ganglion (SPG) blockade or lesioning can offer significant pain relief for cluster headaches (CHs) and a variety of other pain syndromes involving the head and face. We reviewed the literature on the efficacy of SPG block and radiofrequency ablation (RFA) using PubMed and Google Scholar. The infrazygomatic technique can be used to directly access the SPG for injection of local anesthetic or lesioning using RFA. Read More

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http://dx.doi.org/10.31486/toj.18.0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447206PMC
January 2019

CGRP and the Trigeminal System in Migraine.

Headache 2019 Apr 14. Epub 2019 Apr 14.

Eli Lilly and Company, Indianapolis, IN, USA.

Objective: The goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene-related peptide (CGRP) within the context of the trigeminovascular system.

Background: Migraine is a prevalent and disabling neurological disease that is characterized in part by intense, throbbing, and unilateral headaches. Despite recent advances in understanding its pathophysiology, migraine still represents an unmet medical need, as it is often underrecognized and undertreated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13529
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http://dx.doi.org/10.1111/head.13529DOI Listing
April 2019
2 Reads

Primary headaches during lifespan.

J Headache Pain 2019 Apr 8;20(1):35. Epub 2019 Apr 8.

Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of symptoms within every headache attack. There is no systematic review of whether these symptoms changes during lifespan. Read More

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http://dx.doi.org/10.1186/s10194-019-0985-0DOI Listing
April 2019
3 Reads

Prevalence of headache attributed to aeroplane travel in headache outpatient populations: An Italian multicentric survey.

Cephalalgia 2019 Apr 8:333102419843676. Epub 2019 Apr 8.

2 Headache Centre, Department of Neurosciences, University of Padua, Padua, Italy.

Background: To assess the prevalence of headache attributed to aeroplane travel (AH) in patients referred to Italian Headache Centres.

Material And Method: 869 consecutive patients visiting six Italian headache centres during a 6 month-period (October 2013 to March 2014) were enrolled in the survey. Among them, 136 (15. Read More

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http://dx.doi.org/10.1177/0333102419843676DOI Listing
April 2019
2 Reads

Hyperalgesia and Central Sensitization Signs in Patients with Cluster Headache: A Cross-Sectional Study.

Pain Med 2019 Apr 8. Epub 2019 Apr 8.

La Paz University Hospital Institute for Health Research, Madrid, Spain.

Objective: To investigate central sensitization (CS) in cluster headache (CH) and to evaluate its relationship with disease characteristics and psychological comorbidities.

Design: Cross-sectional study.

Settings: Whether CS occurs in CH, as it does in other primary headaches, is a subject of debate. Read More

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http://dx.doi.org/10.1093/pm/pnz070DOI Listing
April 2019
2 Reads

[Symptomatic trigeminal autonomic cephalalgia without headache].

Ideggyogy Sz 2019 Mar;72(3-4):135-139

Péterfy Sándor Utcai Kórház, Neurológiai Osztály, Budapest.

We report the case of a 60-year-old man who exhibited trigeminal autonomic symptoms on his right side (numbness of the face, reddening of the eye, nasal congestion) occurring several times a day, for a maximum of 60 se-conds, without any pain. The complaints were similar to trigeminal autonomic cephalalgia, just without any headache. Our 60-year-old male patient underwent a craniocervical MRI as part of his neurological workup, which revealed lesions indicative of demyelination. Read More

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http://dx.doi.org/10.18071/isz.72.0135DOI Listing

Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature.

Headache 2019 Apr 7;59(4):576-589. Epub 2019 Apr 7.

Service de Psychiatrie et Psychologie, INSERM UMR 1043, Université de Toulouse III, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

Objective: To describe a case series of 7 patients presenting cluster headache (CH) criteria and a substance use disorder, reported to a French Addictovigilance center. Then, to assess clinical, pharmacological, and neurobiological linkages between substance use and CH onset.

Background: CH patients are presenting a higher prevalence of comorbidities, among which the use of psychoactive substances, licit or illicit, have been explored by a few authors. Read More

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http://dx.doi.org/10.1111/head.13516DOI Listing
April 2019
1 Read

Symptom Clusters in People Living With HIV: A Systematic Review.

J Pain Symptom Manage 2019 Apr 2. Epub 2019 Apr 2.

Fudan University School of Nursing, Shanghai, China; Fudan University Centre for Evidence-based Nursing: A Joanna Briggs Institute Centre of Excellence, Shanghai, China. Electronic address:

Context: An increasing number of studies regarding symptom management have begun to shift their focus from managing a single symptom to multiple symptom clusters. However, there is a lack of consistency of compositions among different studies and even in two different analyses reported in a single study within the same population.

Objectives: The aim of this systematic review was to summarize the compositions, measures, and data analysis techniques of symptom clusters in people living with HIV (PLWH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08853924193013
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http://dx.doi.org/10.1016/j.jpainsymman.2019.03.018DOI Listing
April 2019
2 Reads

Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial.

Lancet 2019 Apr 1. Epub 2019 Apr 1.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK. Electronic address:

Background: Previous prospective cohort studies have shown that angiogenic factors have a high diagnostic accuracy in women with suspected pre-eclampsia, but we remain uncertain of the effectiveness of these tests in a real-world setting. We therefore aimed to determine whether knowledge of the circulating concentration of placental growth factor (PlGF), an angiogenic factor, integrated with a clinical management algorithm, decreased the time for clinicians to make a diagnosis in women with suspected pre-eclampsia, and whether this approach reduced subsequent maternal or perinatal adverse outcomes.

Methods: We did a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial in 11 maternity units in the UK, which were each responsible for 3000-9000 deliveries per year. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)33212-4DOI Listing
April 2019
2 Reads

OnabotulinumtoxinA in Migraine and Other Headaches: Review and Update.

Curr Treat Options Neurol 2019 Apr 4;21(4):21. Epub 2019 Apr 4.

Department of Neurology, University of California, Davis, 4160, Y St., No. 3700, Sacramento, CA, 95817, USA.

Purpose Of The Review: The role of onabotulinumtoxinA in headache management was serendipitously found over a decade ago and approved for chronic migraine in 2010 based on pivotal studies. The purpose of this review is to highlight the impact on headache and other health parameters which is critically reviewed, as well as the putative mechanisms of action.

Recent Findings: OnabotulinumtoxinA is effective in migraine, not only headache frequency and pain intensity but also other health parameters including quality of life. Read More

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http://dx.doi.org/10.1007/s11940-019-0561-6DOI Listing
April 2019
1 Read

Cluster headache: insights from resting-state functional magnetic resonance imaging.

Neurol Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Neuroradiology, IRCCS Fondazione Istituto Neurologico 'Carlo Besta', 20133, Milan, Italy.

The comprehension of cluster headache (CH) has greatly benefited from the tremendous progress of the neuroimaging techniques over the last 20 years. Since the pioneering study of May et al. (1998), the neuroimaging results have indeed revolutionized the conception of this disease, now considered as a dysfunction of the central nervous system. Read More

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http://dx.doi.org/10.1007/s10072-019-03874-8DOI Listing
April 2019
5 Reads

The Development of Evidence-Based Guideline for Diagnosis and Management of Headache in Korea.

Psychiatry Investig 2019 Mar 21;16(3):199-205. Epub 2019 Mar 21.

Department of Psychiatry, Wonkwang University School of Medicine and Hospital, Iksan, Republic of Korea.

Objective: We aimed to develop the clinical guideline for headache by the systematic review and synthesis of existing evidence-based guidelines. The purpose of developing the guideline was to improve the appropriateness of diagnosis and treatment of headache disorder, and consequently, to improve patients' pain control and quality of life. The guideline broadly covers the differential diagnosis and treatment of tension-type headache, migraine, cluster headache, and medication-overuse headache. Read More

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http://dx.doi.org/10.30773/pi.2018.11.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444101PMC
March 2019
2 Reads

Altered neural activity to monetary reward/loss processing in episodic migraine.

Sci Rep 2019 Apr 1;9(1):5420. Epub 2019 Apr 1.

SE-NAP2 Genetic Brain Imaging Migraine Research Group, Semmelweis University, Budapest, Hungary.

The dysfunctions of the mesolimbic cortical reward circuit have been proposed to contribute to migraine pain. Although supporting empirical evidence was mainly found in connection with primary rewards or in chronic migraine where the pain experience is (almost) constant. Our goal however was to investigate the neural correlates of secondary reward/loss anticipation and consumption using the monetary incentive delay task in 29 episodic migraine patients and 41 headache-free controls. Read More

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http://dx.doi.org/10.1038/s41598-019-41867-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443660PMC
April 2019
5 Reads

Genetics of cluster headache.

Cephalalgia 2019 Mar 27:333102418815503. Epub 2019 Mar 27.

1 Xenon Pharmaceuticals Inc, Burnaby, Canada.

Background: Cluster headache is the most severe primary headache disorder. A genetic basis has long been suggested by family and twin studies; however, little is understood about the genetic variants that contribute to cluster headache susceptibility.

Methods: We conducted a literature search of the MEDLINE database using the PubMed search engine to identify all human genetic studies for cluster headache. Read More

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http://dx.doi.org/10.1177/0333102418815503DOI Listing
March 2019
1 Read

The spectrum of cluster headache: A case report of 4600 attacks.

Cephalalgia 2019 Mar 26:333102419833081. Epub 2019 Mar 26.

1 Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Glostrup, Denmark.

Introduction: Knowledge of the clinical features of cluster headache is mainly based on retrospective and cross-sectional studies. Here, we present a case of a chronic cluster headache patient who prospectively recorded timing and clinical features of all attacks for 6 years, aiming to describe the clinical spectrum and timing of cluster headache symptoms experienced and to identify daily and/or seasonal rhythmicity.

Methods: Registration of attack timing, duration, associated symptoms and severity was done prospectively on a smartphone application. Read More

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http://journals.sagepub.com/doi/10.1177/0333102419833081
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http://dx.doi.org/10.1177/0333102419833081DOI Listing
March 2019
1 Read

Behavioral and psychological aspects of cluster headache: an overview.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Psychology, University of Memphis, 400 Innovation Drive, Memphis, TN, 38152, USA.

This paper overviews available literature addressing behavioral and psychological aspects of cluster headache. Behavioral correlates of sleep and drug use are explored, as are the psychological correlates pertaining to psychopathology and cognitive functioning. We conclude with a review of the few investigations addressing adjunctive behavioral treatments for cluster headache, and provide suggestions for possible ways to enhance effects of behavioral interventions for this painful and difficult to treat headache disorder. Read More

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http://dx.doi.org/10.1007/s10072-019-03831-5DOI Listing

Clinical features of cluster headache in relation to age of onset: results from a retrospective study of a large case series.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Headache Center, Department of Medicine and Surgery, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1007/s10072-019-03801-xDOI Listing

Sleep disorder-related headaches.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy.

Migraine with and without aura, cluster headache, hypnic headache, and paroxysmal hemicranias are each reported as intrinsically related to sleep. Chronic migraine, chronic tension-type headache, and medication overuse headache may cause sleep disturbance. Otherwise, both headache and sleep disorder may be manifestations of a same systemic dysfunction. Read More

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http://dx.doi.org/10.1007/s10072-019-03837-zDOI Listing
March 2019
2 Reads

Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache.

Neurol Sci 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Institute of Clinical Sciences, Lund University, Lund, Sweden.

Migraine is a common, severe disease, affecting the brain and blood vessels, causing much pain, time missed from work and family, and severe disability. It affects approximately 12% of most Western populations studied and affects women three times more than men. Cluster headache is a much less common dysfunction of the hypothalamus, involving the sphenopalatine ganglion and other areas; it causes more frequent, shorter, and even more intense pain than migraine. Read More

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http://dx.doi.org/10.1007/s10072-019-03828-0DOI Listing
March 2019
1 Read

Multicentre, prospective, randomised, controlled, blinded-endpoint study to evaluate the efficacy and safety of pterygopalatine ganglion pulsed radiofrequency treatment for cluster headache: study protocol.

BMJ Open 2019 Mar 23;9(3):e026608. Epub 2019 Mar 23.

Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Introduction: Single-centre reports on small groups of patients have shown that pterygopalatine ganglion pulsed radiofrequency treatment in patients with refractory cluster headache (CH) can quickly relieve pain without significant side effects. However, a randomised controlled trial is still necessary to evaluate whether pterygopalatine ganglion pulsed radiofrequency (PRF) treatment is a viable treatment option for patients with CH who are not responding to drug treatment.

Methods And Analysis: This investigation is a multicentre, prospective, randomised, controlled, blinded-endpoint study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026608DOI Listing
March 2019
1 Read

Occipital Nerve Stimulation.

Neurosurg Clin N Am 2019 Apr 18;30(2):211-217. Epub 2019 Feb 18.

Department of Neurosurgery, University of Illinois at Chicago, 912 South Wood Street, M/C 799, Chicago, IL 60612, USA.

Although the first publications on clinical use of peripheral nerve stimulation for the treatment of chronic pain came out in the mid-1960s, it took 10 years before this approach was used to stimulate the occipital nerves. The future for occipital nerve stimulation is likely to bring new indications, devices, stimulation paradigms, and a decrease in invasiveness. As experience increases, one may expect that occipital nerve stimulation will eventually gain regulatory approval for more indications, most likely for occipital neuralgia, migraines and cluster headaches. Read More

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http://dx.doi.org/10.1016/j.nec.2018.12.004DOI Listing
April 2019
2 Reads

Ventral tegmental area deep brain stimulation for chronic cluster headache: Effects on cognition, mood, pain report behaviour and quality of life.

Cephalalgia 2019 Mar 21:333102419839957. Epub 2019 Mar 21.

1 Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.

Background: Deep brain stimulation in the ventral tegmental area (VTA-DBS) has provided remarkable therapeutic benefits in decreasing headache frequency and severity in patients with medically refractory chronic cluster headache (CH). However, to date the effects of VTA-DBS on cognition, mood and quality of life have not been examined in detail.

Methods: The aim of the present study was to do so in a case series of 18 consecutive patients with cluster headache who underwent implantation of deep brain stimulation electrodes in the ventral tegmental area. Read More

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http://dx.doi.org/10.1177/0333102419839957DOI Listing
March 2019
5 Reads

Deep brain stimulation of chronic cluster headaches: Posterior hypothalamus, ventral tegmentum and beyond.

Cephalalgia 2019 Mar 21:333102419839992. Epub 2019 Mar 21.

3 Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.

Objective: We present long-term follow-up results and analysis of stimulation sites of a prospective cohort study of six patients with chronic cluster headaches undergoing deep brain stimulation of the ipsilateral posterior hypothalamic region.

Methods: The primary endpoint was the postoperative change in the composite headache severity score "headache load" after 12 months of chronic stimulation. Secondary endpoints were the changes in headache attack frequency, headache attack duration and headache intensity, quality of life measures at 12, 24, and 48 months following surgery. Read More

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http://dx.doi.org/10.1177/0333102419839992DOI Listing

Emerging treatments for cluster headache: hopes and disappointments.

Authors:
Delphine Magis

Curr Opin Neurol 2019 Mar 19. Epub 2019 Mar 19.

Headache Research Unit, University Department of Neurology CHR, Centre Hospitalier Universitaire de Liege, Liege, Belgium.

Purpose Of Review: Cluster headache stands among the worst debilitating pain conditions. Available treatments for cluster headache have often disabling side effects, are not tolerated, or are ineffective. The management of drug-refractory chronic forms is challenging. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000693DOI Listing
March 2019
2 Reads

Leading symptoms in cerebrovascular diseases: what about headache?

Neurol Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Neuroscience, Neurology and Stroke Unit, ASST GOM Niguarda Cà Granda Hospital, Piazza Ospedale Maggiore 3, 20162, Milan, Italy.

Headache is a milestone in cerebrovascular disorders; indeed, it may represent the only symptom at onset or predominates over the other neurological features. Unfortunately, headache associated with cerebrovascular diseases lacks clear-cut characteristics as it may resemble a migraine attack, tension-type headache, or cluster headache; pain localization is also misleading along with drug (analgesic) response. However, in this review, we have analyzed and described the most common patterns of headache for different vascular disorders: it is known that headache due to subarachnoid aneurysmal hemorrhage presents peculiar characteristics (thunderclap, acute presentation, and high intensity), whereas in cerebral vasoconstriction syndrome, the short duration and the relapsing-remitting course of the thunderclap headache are key points for the diagnosis; in cervicocerebral artery, dissection pain is most commonly ipsilateral to the dissected vessel and is mainly perceived in the temporal area in case of carotid artery dissection and in the occipital area in case of vertebral artery dissection; in cerebral venous thrombosis, pain is often acute or subacute and severe; unfortunately, it may resemble a typical migraine attack or a tension-type episode; by the contrary, in primary angiitis of the central nervous system, pain is always subacute or chronic with mild-to-moderate intensity; finally, in brain arteriovenous shunts such as malformation or fistula, pain is more frequently a clue for disease complication such as hemorrhage from the malformation or thrombosis of the draining vein. Read More

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http://link.springer.com/10.1007/s10072-019-03793-8
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http://dx.doi.org/10.1007/s10072-019-03793-8DOI Listing
March 2019
4 Reads

Endogenous Neurostimulation and Physiotherapy in Cluster Headache: A Clinical Case.

Brain Sci 2019 Mar 12;9(3). Epub 2019 Mar 12.

Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid 28023, Spain.

Objective: The aim of this paper is to describe the progressive changes of chronic cluster headaches (CHs) in a patient who is being treated by a multimodal approach, using pharmacology, neurostimulation and physiotherapy.

Subject: A male patient, 42 years of age was diagnosed with left-sided refractory chronic CH by a neurologist in November 2009. In June 2014, the patient underwent a surgical intervention in which a bilateral occipital nerve neurostimulator was implanted as a treatment for headache. Read More

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http://dx.doi.org/10.3390/brainsci9030060DOI Listing
March 2019
5 Reads

[Migraine, trigeminal neuralgia and cluster headache].

Authors:
Caroline Roos

Rev Prat 2018 Nov;68(9):e339-e350

Neurologue, responsable du centre d'urgence des céphalées, hôpital Lariboisière, 75010 Paris, France.

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November 2018
1 Read

The unique role of the trigeminal autonomic reflex and its modulation in primary headache disorders.

Curr Opin Neurol 2019 Mar 6. Epub 2019 Mar 6.

Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany.

Purpose Of Review: The trigeminal autonomic reflex is a physiological reflex with an important protective function which also plays a role in pathophysiological conditions, such as primary headache. It is not understood whether the autonomic symptoms in trigeminal autonomic cephalalgias and migraine are the consequence of severe trigeminal discharge or indeed directly driven by central generators as part of the pathophysiology, underlying these syndromes.

Recent Findings: Modulating this reflex, and particularly the parasympathetic reflex arc, has been shown to be effective in treating headache. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000691DOI Listing
March 2019
1 Read

Hemiplegic cluster headache: A case report and review of the literature.

Neurol India 2019 Jan-Feb;67(1):287-288

Department of Neurology, Smt. B. K. Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

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http://dx.doi.org/10.4103/0028-3886.253626DOI Listing
March 2019
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Field testing the diagnostic criteria of cluster headache in the third edition of the International Classification of Headache Disorders: A cross-sectional multicentre study.

Cephalalgia 2019 Mar 11:333102419837159. Epub 2019 Mar 11.

17 Department of Neurology, Severance Hospital, Yonsei University School of Medicine, Seoul, Korea.

Background: *These authors are shared first authors. The recently published third edition of the International Classification of Headache Disorders (ICHD-3) revised the criteria for accompanying symptoms of cluster headache (CH) and the remission period of chronic cluster headache (CCH). This study aimed at testing the validity of the ICHD-3 criteria for CH by using data from the Korean Cluster Headache Registry. Read More

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http://dx.doi.org/10.1177/0333102419837159DOI Listing
March 2019
4 Reads

Calcitonin-gene related peptide and disease activity in cluster headache.

Cephalalgia 2019 Apr 9;39(5):575-584. Epub 2019 Mar 9.

1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objective: To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these vasoactive peptides interictally and during experimentally induced cluster headache attacks.

Methods: We included patients with episodic cluster headache in an active phase (n = 9), episodic cluster headache patients in remission (n = 9) and patients with chronic cluster headache (n = 13). Cluster headache attacks were induced by infusion of calcitonin gene-related peptide (1. Read More

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http://dx.doi.org/10.1177/0333102419837154DOI Listing
April 2019
1 Read

Mexican Americans' diabetes symptom prevalence, burden, and clusters.

Appl Nurs Res 2019 Apr 13;46:37-42. Epub 2019 Feb 13.

The University of Texas at Austin School of Nursing, Austin, TX, United States of America.

Aims: Type 2 diabetes mellitus (T2DM), serious and increasingly prevalent among Mexican Americans, produces symptoms related to high and low glucose levels, medication side effects, and long-term complications. This secondary analysis explored symptom prevalence, differences among symptom burden levels, and how symptoms clustered.

Methods: Clinical measurements and survey data (demographic, quality of life, and the symptom subscale of the Diabetes Symptom Self-Management Inventory) collected from Mexican American adults with T2DM (n = 71) were analyzed for symptom prevalence, differences across levels of symptom burden, and symptom clusters. Read More

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http://dx.doi.org/10.1016/j.apnr.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417834PMC
April 2019
1 Read

[Headache - an Update 2018].

Laryngorhinootologie 2019 Mar 7;98(3):192-217. Epub 2019 Mar 7.

Epidemiological studies have shown a clear correlation between migraine and vascular disease in more and more patients. Pathophysiological studies show the relevance of the hypothalamus in the generation of migraine attacks. Glutamate seems to play an important role here. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0823-4814
Publisher Site
http://dx.doi.org/10.1055/a-0823-4814DOI Listing
March 2019
10 Reads

The influence of lifestyle and gender on cluster headache.

Curr Opin Neurol 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurology, Danish Headache Center, University of Copenhagen, Copenhagen, Denmark.

Purpose Of Review: Cluster headache is by many regarded as a males' disorder that is often accompanied by an unhealthy lifestyle. We aimed to study the influence of sex and lifestyle factors on clinical presentation, the diagnostic process and management.

Recent Findings: Overall, the clinical presentation of cluster headache in both sexes was similar; however, chronic cluster headache may occur more frequently in women than in men. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000680DOI Listing
February 2019
5 Reads

Promote Biomarker Discovery by Identifying Homogenous Primary Headache Subgroups.

Headache 2019 Mar 7. Epub 2019 Mar 7.

Independent researcher, Copenhagen, Denmark.

Within- and between-study heterogeneity impede identification of valid primary headache biomarkers. Homogenous subgroup identification and investigation of differential biochemical profiles and networks within and across headache categories, based on statistical techniques, might promote biomarker discovery. When studying common primary headaches with a multifactorial etiology, variability might be captured at different levels (eg, genetics, clinical features, comorbidities, triggers). Read More

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http://dx.doi.org/10.1111/head.13499DOI Listing
March 2019
1 Read

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report.

J Neurosurg 2019 Mar 1:1-4. Epub 2019 Mar 1.

2Department of Neurology, University of São Paulo Medical School, São Paulo.

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Read More

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http://dx.doi.org/10.3171/2018.11.JNS181412DOI Listing
March 2019
1 Read

The neurosurgical treatment of craniofacial pain syndromes: current surgical indications and techniques.

Neurol Sci 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.

Craniofacial pain syndromes are comprised of multiple pathological entities resulting in pain referred to the scalp, face, or deeper cranial structures. In a small subset of patients affected by those syndromes, pharmacological and physical therapies fail in alleviating pain. In some of those refractory patients surgical procedures aimed at relieving pain are indicated and have been adopted with variable results and safety profiles. Read More

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http://dx.doi.org/10.1007/s10072-019-03789-4DOI Listing
March 2019
2 Reads
1.495 Impact Factor

CGRP and headache: a brief review.

Authors:
Stewart J Tepper

Neurol Sci 2019 Mar 5. Epub 2019 Mar 5.

Neurology Department, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03756, USA.

The advent of anti-CGRP medications is an example of translational research made real. Pioneering research by Drs. Lars Edvinsson and Peter Goadsby has yielded the monoclonal antibody therapeutics and will likely also result in the gepants. Read More

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http://dx.doi.org/10.1007/s10072-019-03769-8DOI Listing
March 2019
7 Reads

The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review.

Neurol Sci 2019 Mar 2. Epub 2019 Mar 2.

Research and Innovation (R&I) s.r.l., Padua, Italy.

The pathogenesis underlying cluster headache remains an unresolved issue. Although both the autonomic system and the hypothalamus play a central role, the modality of their involvement remains largely unknown. It is, also, unknown why the duration of the pain attacks is so brief and why their onset and termination are abrupt and extremely painful. Read More

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http://dx.doi.org/10.1007/s10072-019-03768-9DOI Listing

Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials.

J Neurol Neurosurg Psychiatry 2019 Mar 1. Epub 2019 Mar 1.

Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Non-invasive neuromodulation therapies for migraine and cluster headache are a practical and safe alternative to pharmacologics. Comparisons of these therapies are difficult because of the heterogeneity in study designs. In this systematic review of clinical trials, the scientific rigour and clinical relevance of the available data were assessed to inform clinical decisions about non-invasive neuromodulation. Read More

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http://dx.doi.org/10.1136/jnnp-2018-320113DOI Listing
March 2019
1 Read

Anti-CGRP in cluster headache therapy.

Neurol Sci 2019 Feb 28. Epub 2019 Feb 28.

Neuroalgology Department, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, 20133, Milan, Italy.

Cluster headache is a primary headache characterized by recurring excruciating pain and autonomic signs, leading to significant suffering and derangement of patients' life. Efficacious new preventive treatments are needed. The pathophysiology of cluster headache comprises mechanisms both in the peripheral and central nervous system, involving the trigeminovascular system, the trigemino-parasympathetic reflex, and central modulating systems. Read More

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http://dx.doi.org/10.1007/s10072-019-03786-7DOI Listing
February 2019
4 Reads

Cluster headache in relation to different age groups.

Neurol Sci 2019 Feb 23. Epub 2019 Feb 23.

Headache Centre, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Cluster headache (CH) has always been considered a type of primary headache affecting predominantly male subjects in early and medium adulthood. However, recent studies carried out in large case series of patients with CH show that not infrequently it may set in also after age 50; by contrast, onset before adolescence is very rare. Additionally, when onset occurs before age 14 or from the sixth decade of life onward, male predominance decreases to the point that in chronic forms CH predominantly affects the female sex. Read More

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http://dx.doi.org/10.1007/s10072-019-03767-wDOI Listing
February 2019
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Neuromodulation for the treatment of primary headache syndromes.

Expert Rev Neurother 2019 Mar 8;19(3):261-268. Epub 2019 Mar 8.

a Department of Systems Neuroscience , University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Introduction: Neuromodulation techniques play an increasing role in the treatment of primary headaches. While initially reserved for refractory cases they are now increasingly taken into consideration in earlier treatment phases and in non-refractory situations. One of the main reasons for this paradigm shift is that most neuromodulation techniques are better tolerated as compared to the majority of pharmacological approaches. Read More

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http://dx.doi.org/10.1080/14737175.2019.1585243DOI Listing
March 2019
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Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019
4 Reads

Changes in grey matter volume and functional connectivity in cluster headache versus migraine.

Brain Imaging Behav 2019 Feb 14. Epub 2019 Feb 14.

Headache Centre, Careggi University Hospital, Department of Health Sciences, University of Florence, Florence, Italy.

Cluster headache (CH) shows a more severe clinical picture than migraine (Mig). We tested whether brain changes can explain such difference. Multimodal MRI was acquired in attack-free patients with CH (n = 12), Mig (n = 13) and in normal controls (NC, n = 13). Read More

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http://dx.doi.org/10.1007/s11682-019-00046-2DOI Listing
February 2019
1 Read
3.385 Impact Factor

Cluster-Like Headache Secondary to Anamnesis of Sphenoid Ridge Meningioma: A Case Report and Literature Review.

Front Neurol 2019 25;10:23. Epub 2019 Jan 25.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cluster headache is generally considered to be a primary headache; secondary cluster-like headache is quite rare, while cluster-like headache secondary to meningioma is even rarer. Here, we describe an unusual case with cluster-like headache 2.5 years after sphenoid ridge meningioma surgery. Read More

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http://dx.doi.org/10.3389/fneur.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357285PMC
January 2019
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Points & Pearls: Evaluation and management of life-threatening headaches in the emergency department

Emerg Med Pract 2019 Feb 1;21(Suppl 2):1-2. Epub 2019 Feb 1.

EMS Fellow, University of Pittsburgh Medical Center, Pittsburgh, PA

Headache is the fourth most common reason for emergency department encounters, accounting for 3% of all visits in the United States. Though troublesome, 90% are relatively benign primary headaches --migraine, tension, and cluster headaches. The other 10% are secondary headaches, caused by separate underlying processes, with vascular, infectious, or traumatic etiologies, and they are potentially life-threatening. Read More

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February 2019
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Nonmigraine Headache and Facial Pain.

Med Clin North Am 2019 Mar 20;103(2):235-250. Epub 2018 Dec 20.

Department of Neurology, Brigham and Women's Hospital, John R. Graham Headache Center, Brigham and Women's Faulkner Hospital, Harvard Medical School, 1153 Centre Street, Suite 4H, Boston, MA 02130, USA. Electronic address:

The vast majority of headache patients encountered in the outpatient general medicine setting will be diagnosed with a primary headache disorder, mostly migraine or tension-type headache. Other less common primary headaches and secondary headaches, related to or caused by another condition, are the topic of this article. Nonmigraine primary headaches include trigeminal autonomic cephalalgias, primarily cluster headache; facial pain, primarily trigeminal neuralgia; and miscellaneous headache syndromes, such as hemicrania continua and new daily persistent headache. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.007DOI Listing
March 2019
18 Reads