2,809 results match your criteria Clubbing of the Nails


A rare case of large aortopulmonary window with Eisenmenger syndrome and adult survival.

J Cardiol Cases 2014 Nov 19;10(5):193-195. Epub 2014 Aug 19.

Department of Radiology, Sanjay Gandhi PGIMS, Lucknow, India.

Patients with polycythemia have an abnormally elevated hemoglobin, hematocrit, and red cell count. It is important to differentiate primary polycythemia from secondary causes since this can affect patient management and prognosis. We report the case of a young male, suspected to have primary polycythemia who was referred for a cardiology opinion after a bone marrow examination was normal and testing for Janus kinase gene mutation was negative. Read More

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November 2014
1 Read

Pulmonary alveolar proteinosis - a crazy presentation of dyspnea.

Eur Clin Respir J 2019 4;6(1):1552065. Epub 2018 Dec 4.

Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark.

This case report demonstrates 44-year old man, presenting with recurring clinical pneumonias during a period of over 1 year. The patient was clinically affected with, i.a. Read More

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December 2018
2 Reads

Left Atrial Drainage of the Right Superior Vena Cava: A Case Report.

J Tehran Heart Cent 2018 Apr;13(2):84-87

Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.

An isolated right superior vena cava (RSVC) draining into the left atrium represents a very rare congenital malformation, especially in the absence of a partial anomalous pulmonary venous return. This condition leads to hypoxemia, cyanosis, and clubbing without any other signs of heart defects. We describe an 8-year-old girl, who was referred to our hospital due to unexplained cyanosis. Read More

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April 2018
2 Reads

Polycythemia Rubra Vera Presenting as Unilateral Clubbing Due to Left Subclavian Artery Thrombosis.

J Assoc Physicians India 2018 May;66(5):90-91

Professor, Govt. Medical College, Calicut, Kerala.

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May 2018
3 Reads

A novel mutation in the gene results in the unusual phenotype of palmoplantar keratoderma with digital clubbing and hyperhidrosis.

JAAD Case Rep 2018 Oct 12;4(9):950-952. Epub 2018 Oct 12.

Department of Dermatology, American University of Beirut, Beirut, Lebanon.

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October 2018
4 Reads

Morphologic pattern analysis of submucosal deformities identified by endoscopic ultrasonography for predicting the depth of invasion in early gastric cancer.

Surg Endosc 2018 Oct 17. Epub 2018 Oct 17.

Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.

Background: The aims of this study are to evaluate the usefulness of submucosal deformity pattern analysis with endoscopic ultrasonography (EUS) for predicting the depth of invasion in early gastric cancer (EGC) and the treatment results of endoscopic submucosal dissection (ESD).

Methods: The endoscopic and EUS parameters of 345 patients with endoscopically suspected EGC who underwent endoscopic or surgical resection between July 2012 and May 2017 were retrospectively reviewed. All patients were classified into three categories as follows according to the morphologic type of submucosal deformity identified by EUS: (1) no submucosal deformity, (2) wedge-shaped deformity, and (3) arch-shaped deformity. Read More

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October 2018
8 Reads

A retrospective analysis of distinguishing features of chest HRCT and clinical manifestation in primary Sjögren's syndrome-related interstitial lung disease in a Chinese population.

Clin Rheumatol 2018 Nov 22;37(11):2981-2988. Epub 2018 Sep 22.

Department of Rheumatology and Immunology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gong-Ti South Road, Chaoyang District, Beijing, 100020, People's Republic of China.

To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospectively analyzed. ILD was defined based on the presences of pulmonary signs in HRCT. Read More

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November 2018
3 Reads

We Do Not Know What Queers Can Do: LGBT Community Between (In)visibility and Culture Industry in Serbia at the Beginning of the 21st Century.

J Homosex 2018 Sep 20:1-22. Epub 2018 Sep 20.

a Department of Humanities and Art and Media Theory, Faculty of Media and Communications , Singidunum University , Belgrade , Serbia.

This article analyzes the ways in which LGBT community in Serbia is produced as both visible and invisible in activism and culture industry through affective labor performed as identification with the project of Europeanization of Serbian society (social subjection), and immaterial labor performed within culture industry by participating in the clubbing scene (machinic enslavement). LGBT community in Serbia has a potential for becoming other than a homonormativized group of consumers, especially when those who are produced as invisible are taken into account, and spatially and socially marginalized spaces where alternative forms of culture and politics are made and lived. Read More

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September 2018
2 Reads

Pulmonary Arteriovenous Malformations.

QJM 2018 Sep 12. Epub 2018 Sep 12.

Department of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.

A 34-year-old gentleman, presented with a recurrent headache, redness of the face, and shortness of breath for six months. He had congestive palpebral conjunctiva, reddish face and drumstick appearance of the fingers with loss of Lovibond angle. His SpO2 82 % at room air. Read More

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September 2018
3 Reads

Dental considerations and recommendations in Eisenmenger syndrome: A report of an unusual paediatric case.

Eur Arch Paediatr Dent 2018 Dec 8;19(6):449-453. Epub 2018 Sep 8.

Paediatric Dentistry Postgraduate Programme, Faculty of Dentistry, San Luis Potosi University, San Luis Potosí, SLP, Mexico.

Background: Eisenmenger syndrome (ES) is a heart cyanotic condition characterised by elevated pulmonary vascular resistance and an intra-cardiac right-to-left shunting of blood through a systemic-to-pulmonary circulation connection. Affected children usually exhibit severe hypoxia, clubbing of fingers/toes, haemoptysis, anaemia, and organ damage.

Case Report: During autumn 2015, the patient and her parents arrived at the paediatric dentistry clinic. Read More

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December 2018
7 Reads

Thyroid dermopathy and acropachy in pediatric patients.

Pediatr Dermatol 2018 Nov 6;35(6):e371-e374. Epub 2018 Sep 6.

George Washington University School of Medicine & Health Sciences, Washington, District of Columbia.

The extrathyroid manifestations of Graves disease (GD) include thyroid orbitopathy, dermopathy, and acropachy. Thyroid dermopathy (TD), also known as pretibial myxedema, classically presents as nonpitting edema or plaquelike lesions on the pretibial region, while thyroid acropachy (TA) is seen in cases of severe TD, characterized by soft tissue swelling and clubbing of fingers and toes, as well as a periosteal reaction of the bones of the hands and feet. Both TD and TA are rare manifestations of thyroid disease and uncommonly reported in pediatric patients. Read More

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November 2018
5 Reads

Tree-in-Bud Pattern of Pulmonary Tuberculosis on Thin-Section CT: Pathological Implications.

Korean J Radiol 2018 Sep-Oct;19(5):859-865. Epub 2018 Aug 6.

University of Fukui, School of Medical Sciences, Bunkyo, Fukui-shi, Fukui 910-8507, Japan.

The "tree-in-bud-pattern" of images on thin-section lung CT is defined by centrilobular branching structures that resemble a budding tree. We investigated the pathological basis of the tree-in-bud lesion by reviewing the pathological specimens of bronchograms of normal lungs and contract radiographs of the post-mortem lungs manifesting active pulmonary tuberculosis. The tree portion corresponds to the intralobular inflammatory bronchiole, while the bud portion represents filling of inflammatory substances within alveolar ducts, which are larger than the corresponding bronchioles. Read More

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August 2018
4 Reads

Congenital nail clubbing.

J Dermatol 2018 Aug 27. Epub 2018 Aug 27.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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August 2018
9 Reads

Diffuse large B-cell lymphoma: A retrospective study from a regional care center in South India.

Indian J Cancer 2018 Jan-Mar;55(1):66-69

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Introduction: Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma whose outcomes have significantly improved with rituximab in addition to anthracycline-based chemotherapy.

Objective: This study aimed to study the epidemiology, treatment, and outcomes of patients with DLBCL.

Materials And Methods: A total of 526 patients diagnosed with DLBCL between 2006 and 2015 were retrospectively analyzed. Read More

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November 2018
9 Reads

Point-of-Care Ultrasound for the Assessment of Digital Clubbing.

Am J Med 2018 Nov 1;131(11):e469-e470. Epub 2018 Aug 1.

Division of General Internal Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada; W21C, University of Calgary, Alberta, Canada. Electronic address:

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November 2018
3 Reads

Pulmonary alveolar proteinosis in children: An unusual presentation with significant clinical impact.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):418-420

Department of Pathology, Anand Diagnostic Laboratory, Bengaluru, Karnataka, India.

Pulmonary alveolar proteinosis (PAP) - an unusual diffuse lung disease characterized by alveolar accumulation of phospholipoprotein material, with a peak incidence in third to fourth decade and male predominance is also described in children. Recorded prevalence is 0.1/100,000 individuals. Read More

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November 2018
3 Reads

Clubbing and pachydermoperiostosis.

Authors:
M-H Lin C-H Hsieh

QJM 2018 Nov;111(11):833-834

Division of Endocrinology and Metabolism, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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November 2018
1 Read

Neonatal Compartment Syndrome Treated Within the First 24 Hours of Life.

Orthopedics 2018 Sep 18;41(5):e731-e733. Epub 2018 Jun 18.

Neonatal compartment syndrome is rare. There are multiple proposed etiologies, including infection, vascular insult, and mechanical compression. Much like compartment syndrome in adults, delayed surgical intervention for neonatal compartment syndrome can have catastrophic results. Read More

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September 2018
1 Read

A Case of Hypertrophic Pulmonary Osteoarthropathy in Both Upper and Lower Extremities: A Rare Involvement.

Mol Imaging Radionucl Ther 2018 Jun;27(2):88-90

Ankara Numune Training and Research Hospital, Clinic of Nuclear Medicine, Ankara, Turkey.

Hypertrophic pulmonary osteoarthropathy (HPOA) is a paraneoplastic manifestation of gastric and, more frequently, lung carcinomas. It is characterized by extremity pain, clubbing, arthritis and periostitis of the long bones. Periostitis is the hallmark of HPOA and can be revealed with bone scintigraphy. Read More

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June 2018
6 Reads

Lung cancer, clubbing and hypertrophic pulmonary osteoarthropathy.

QJM 2018 Nov;111(11):825

Department of Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

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November 2018
6 Reads

Pachydermoperiostosis Mimicking Acromegaly: A Case Report.

Indian Dermatol Online J 2018 May-Jun;9(3):182-184

Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Pachydermoperiostosis is a rare, hereditary disease commonly presenting with digital clubbing, pachyderma, and periosteal hypertrophy. Coarsening of facial features and spade-like enlargement of hands and feet may give rise to a diagnostic dilemma between pachydermoperiostosis and acromegaly. This report highlights a case of a 36-year-old man who presented with broadening of hands and feet, facial skin thickening, and edematous and drooping eyelids for the last 10 years. Read More

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June 2018
6 Reads

Prevalence and Associations of Illicit Drug and Polydrug Use in People Living with HIV in Vienna.

Sci Rep 2018 May 23;8(1):8046. Epub 2018 May 23.

Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090, Vienna, Austria.

We aimed to determine the prevalence of drug and polydrug use in people living with HIV in Austria for the first time for which a two center cross-sectional study was performed. Participants were recruited from consecutive patients during their regularly scheduled visits. In total 438 participants were included in the analysis. Read More

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May 2018
6 Reads

Respiratory manifestations in LPS-responsive beige-like anchor (LRBA) protein-deficient patients.

Eur J Pediatr 2018 Aug 18;177(8):1163-1172. Epub 2018 May 18.

Bone Marrow Transplantation Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) protein deficiency is a rare syndrome of primary immune deficiency and immune dysregulation. In this study, we sought to summarize our experience with respiratory manifestations in LRBA-deficient patients. We conducted a retrospective analysis of the medical records of LRBA-deficient patients treated at Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Read More

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August 2018
3 Reads
1.983 Impact Factor

Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature.

BMC Musculoskelet Disord 2018 May 14;19(1):145. Epub 2018 May 14.

Department of Medical Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume 449, 34149, Trieste, Italy.

Background: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. Read More

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May 2018
7 Reads

A novel homozygous mutation in the SLCO2A1 gene causing pachydermoperiostosis: Efficacy of hydroxychloroquine treatment.

Am J Med Genet A 2018 May;176(5):1253-1257

Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.

Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation. Joint pain, polyarthritis, cutis verticis gyrata, seborrhea, and hyperhidrosis are frequently associated to this condition. We report a 17-year-old boy presented with pain and swelling of knees and ankles, and progressive thickening of skin face with seborrhea from about 4 years. Read More

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May 2018
8 Reads

Secondary Hypertrophic Osteoarthropathy Associated With Pediatric Primary Lung Squamous Cell Carcinoma.

J Clin Rheumatol 2018 Apr 13. Epub 2018 Apr 13.

University of Washington School of Medicine Seattle, WA Division of Pediatric Radiology Department of Radiology University of Washington School of Medicine and Seattle Children's Hospital Seattle, WA. Division of Rheumatology Department of Pediatrics University of Washington School of Medicine and Seattle Children's Hospital Seattle, WA

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April 2018
13 Reads

Olmsted Syndrome with Lateral Supraciliary Madarosis and Clubbing: A Rare Case Report.

Indian Dermatol Online J 2018 Mar-Apr;9(2):114-116

Department of Skin and V.D, Patna Medical College and Hospital, Patna, Bihar, India.

Olmsted syndrome (OS) is a rare congenital, mutilating palmoplantar keratoderma first described by Olmsted in 1927. It starts in the neonatal period or in childhood, and has a slow but progressive disabling course. We report the case of a 16-year-old boy who presented with keratoderma of the palm and soles since childhood with lateral supraciliary madarosis and clubbing. Read More

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April 2018
3 Reads

Metabolic Bone Superscan in Carcinoma Breast with Occult Graves' Disease: Looking Beyond Skeletal Metastases.

Indian J Nucl Med 2018 Apr-Jun;33(2):145-147

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Extrathyroidal manifestations of autoimmune thyroid disorders include thyroid-associated ophthalmopathy, thyroid dermopathy, and thyroid acropachy. Thyroid acropachy is an extreme manifestation of autoimmune thyroid disorder characterized by clubbing and swelling of fingers and toes, with or without periosteal reaction of the distal bones. We present a 50-year-old woman, posttreatment for carcinoma breast (6 years back) and referred for bone scan for generalized body ache. Read More

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April 2018
3 Reads

Incomplete form of Primary Hypertrophic Osteoarthropathy (Touraine-Solente-Gole Syndrome) Masquerading as Polyartrhalgia Diagnosed in Technetium-99m-Methylene Diphosphonate Scintigraphy: An Interesting Case Report.

Indian J Nucl Med 2018 Apr-Jun;33(2):128-131

Department of Nuclear Medicine and PET-CT, Apollo Hospitals, Chennai, Tamil Nadu, India.

The primary hypertrophic osteoarthropathy (PHOA) (pachydermoperiostosis) is a rare genetic/hereditary disease characterized by skin changes (pachydermia), clubbing of fingers and periosteal thickening (periostitis) with sub-periosteal new bone formation. Here we describe a case of an adolescent male who presented with clubbing and polyarthralgia. On evaluation with scintigraphy and SPECT-CT, he was diagnosed to have incomplete form of PHOA(skeletal manifestations without skin changes). Read More

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April 2018
7 Reads

Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease.

Can Respir J 2018 23;2018:3640967. Epub 2018 Jan 23.

Department of Pulmonary Medicine, St. Luke's International University, St. Luke's International Hospital, Tokyo, Japan.

Background: Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data.

Methods: We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Read More

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January 2018
4 Reads

Hermansky-Pudlak syndrome type 2 manifests with fibrosing lung disease early in childhood.

Orphanet J Rare Dis 2018 Mar 27;13(1):42. Epub 2018 Mar 27.

Ludwig-Maximilians University, Dr von Haunersches Kinderspital, German Center for Lung Research (DZL), Lindwurmstr. 4, 80337, Munich, Germany.

Background: Hermansky-Pudlak syndrome (HPS), a hereditary multisystem disorder with oculocutaneous albinism, may be caused by mutations in one of at least 10 separate genes. The HPS-2 subtype is distinguished by the presence of neutropenia and knowledge of its pulmonary phenotype in children is scarce.

Methods: Six children with genetically proven HPS-2 presented to the chILD-EU register between 2009 and 2017; the data were collected systematically and imaging studies were scored blinded. Read More

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March 2018
12 Reads

Sterile Bronchopleural Fistula Following Surgical Removal of Primary Lung Leiomyoma Inducing Secondary Hypertrophic Osteoarthropathy.

Am J Case Rep 2018 Mar 9;19:267-271. Epub 2018 Mar 9.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Read More

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March 2018
9 Reads

Pachydermoperiostosis in a patient with chronic hepatitis B virus infection referred as acromegaly: a case report.

J Med Case Rep 2018 Mar 8;12(1):59. Epub 2018 Mar 8.

Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Background: Primary hypertrophic osteoarthropathy also known as pachydermoperiostosis is a rare genetic disorder that has often been confused with acromegaly because of similar clinical features. Vascular endothelial growth factors which have been implicated in the clinical features of pachydermoperiostosis, have also been shown to be present in chronic hepatitis and implicated in the malignant transformation of hepatitis B infection to hepatocellular carcinoma. To the best of our knowledge there is one reported case of pachydermoperiostosis with chronic hepatitis B infection. Read More

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March 2018
10 Reads

A young female with cyanosis and clubbing.

Eur J Intern Med 2018 08 2;54:e7. Epub 2018 Mar 2.

Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address:

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August 2018
7 Reads

Hypertrophic Osteopathy Associated with Mycotic Pneumonia in a Roe Deer ( Capreolus capreolus).

J Wildl Dis 2018 07 2;54(3):631-634. Epub 2018 Mar 2.

1 Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.

Aspergillus fumigatus is one of the most common Aspergillus species causing disease in individual animals but it rarely affects deer species. We report a case of A. fumigatus infection causing mycotic pneumonia and hypertrophic osteopathy in a roe deer ( Capreolus capreolus). Read More

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July 2018
2 Reads

Secondary hypertrophic osteoarthropathy in a male from the Early Medieval settlement of Lauchheim, Germany.

Int J Paleopathol 2018 Mar 21;20:72-79. Epub 2017 Nov 21.

Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart, Stromeyersdorfstraße 3, 78467, Konstanz, Germany; Eberhard Karls University Tübingen, Institute for Archaeological Science, Rümelinstraße 23, 72070, Tübingen, Germany.

Hypertrophic osteoarthropathy (HOA) is rarely diagnosed in archaeological human skeletons. Here, we report on the well-preserved skeleton of a middle-adult man from the early Medieval settlement site of Lauchheim (Germany) that exhibits pronounced multi-layered shell-like periosteal new bone formation in a bilaterally symmetric fashion on the long bones, the skeletal elements of the pelvis and those of the pectoral girdle. In addition, the two distal phalanges recovered show signs of osteoclastic resorption on their distal tuberosities. Read More

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March 2018
9 Reads

Hypertrophic osteoarthropathy: estrogens, prostaglandinE, prostaglandin A, and the inflammatory reflex.

Clin Rheumatol 2018 Feb 26. Epub 2018 Feb 26.

Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.

It has been claimed that hyperestrogenism occurs in hypertrophic osteoarthropathy (HOA), but not in simple clubbing. However, one of our patients had simple clubbing and hyperestrogenism. We therefore measured estrogens, androgens, sex hormone-binding globulin (SHBG), and gonadotropins in five patients with HOA and in 18 patients with simple clubbing. Read More

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February 2018
5 Reads

Pachydermoperiostosis in a Patient with Crohn's Disease: Treatment and Literature Review.

Iran J Med Sci 2018 Jan;43(1):81-85

Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Pachydermoperiostosis (PDP) is a rare disorder characterized by pachydermia, digital clubbing, periostitis, and an excess of affected males. It is the primary form of hypertrophic osteoarthropathy (HOA) and there are some rare associations of PDP with other disorders. Here we describe a patient with Crohn's disease associated with PDP. Read More

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January 2018
12 Reads

Marseille scoring system for empiric treatment of infective endocarditis.

Eur J Clin Microbiol Infect Dis 2018 May 3;37(5):841-849. Epub 2018 Feb 3.

URMITE, Aix Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU - Méditerranée Infection, 9-21 Boulevard Jean Moulin, 13385, Marseille Cedex 05, France.

Despite advances in medical, surgical, and critical care, infective endocarditis (IE) remains associated with considerable morbidity and mortality. We evaluated the performance of the Marseille score, including clinical data and biological tests obtained within 2 h, to identify patients at high risk of IE in order to initiate early antimicrobial treatment. This was secondarily confirmed using modified ESC criteria combined with molecular testing and fluorodeoxyglucose-positron emission tomography/computed tomography as diagnostic tools. Read More

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May 2018
15 Reads

Successful treatment of pachydermoperiostosis patients with etoricoxib, aescin, and arthroscopic synovectomy: Two case reports.

Medicine (Baltimore) 2017 Nov;96(47):e8865

Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.

Rationale: Pachydermoperiostosis (PDP) is a rare hereditary disorder that affects the skin and bones. PDP is characterized by periostosis, digital clubbing, and pachydermia. Previous studies demonstrated that increased prostaglandin E2 (PGE2) levels resulting from defective protein degradation pathways play a crucial role in PDP pathogenesis, and males were more commonly and severely affected than females. Read More

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November 2017
15 Reads

Pierre-Marie-Bamberger syndrome and solitary fibrous tumor: a rare association.

Asian Cardiovasc Thorac Ann 2018 Feb 29;26(2):154-157. Epub 2018 Jan 29.

3 Pathology Department, 61679 Angeles del Pedregal Hospital , Mexico City, Mexico.

A solitary fibrous tumor originates in the pleura with variable degrees of invasion. Hypertrophic osteoarthropathy, known as Pierre-Marie-Bamberger syndrome, is characterized by clubbing of the fingers due to bone surface and soft tissue calcification, historically known as a bronchogenic carcinoma paraneoplastic syndrome; however, a few cases have been associated with solitary fibrous tumors. We describe the case of a 38-year-old woman who presented with clubbing of the fingers. Read More

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February 2018
9 Reads

A Comparison of Computed Tomographic, Radiographic, Gross and Histological, Dental, and Alveolar Findings in 30 Abnormal Cheek Teeth from Equine Cadavers.

Front Vet Sci 2017 5;4:236. Epub 2018 Jan 5.

Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, United Kingdom.

Background: Equine cheek teeth disorders, especially pulpar/apical infections, can have very serious consequences due to the frequent extension of infection to the supporting bones and/or adjacent paranasal sinuses. Limited studies have assessed the accuracy of computed tomographic (CT) imaging in the diagnosis of these disorders, and no study has directly compared imaging and pathological findings of the alveoli of diseased equine cheek teeth.

Objective: To validate the accuracy of CT and radiographic imaging of cheek teeth disorders by comparing CT and radiographic imaging, gross and histological findings in abnormal cheek teeth and their alveoli extracted from equine cadaver heads. Read More

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January 2018
7 Reads

Proliferative Periostitis – eine seltene Differenzialdiagnose.

Rofo 2018 May 18;190(5):450-453. Epub 2018 Jan 18.

Diagnostic Radiology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

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May 2018
7 Reads

[Clinical and imaging features of pulmonary veno-occlusive disease and pulmonary capillary hemangioma].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Jan;41(1):41-46

Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medice, Shanghai 200433, China.

To improve the diagnosis and treatment of the pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangioma (PCH). The clinical features, radiological findings, laboratory testing and treatment in 8 cases of PVOD/PCH which was diagnosed from 2013 to 2017 were described. PVOD/PCH was rare. Read More

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January 2018
8 Reads

Lung Cancer: Clinical Presentation and Diagnosis.

Authors:
Kelly M Latimer

FP Essent 2018 Jan;464:23-26

US Naval Hospital Sigonella Italy, PSC 836 Box 2670, FPO, AE 09636.

In the absence of screening, most patients with lung cancer are not diagnosed until later stages, when the prognosis is poor. The most common symptoms are cough and dyspnea, but the most specific symptom is hemoptysis. Digital clubbing, though rare, is highly predictive of lung cancer. Read More

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January 2018
12 Reads

Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease.

J Gastroenterol 2018 Aug 8;53(8):907-915. Epub 2018 Jan 8.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. Read More

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August 2018
16 Reads

Effectiveness of non-steroidal anti-inflammatory drugs among patients with primary hypertrophic osteoarthropathy: A systematic review.

J Dermatol Sci 2018 Apr 28;90(1):21-26. Epub 2017 Dec 28.

Division of Dermatology, National Center for Child Health and Development, Tokyo, Japan.

Background: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Read More

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April 2018
12 Reads

[A boy with digital clubbing].

Ned Tijdschr Geneeskd 2017;161:D1807

Maastricht Universitair Medisch Centrum+, afd. Kindergeneeskunde, Maastricht.

A 4-year-old boy was referred because of pan-digital clubbing and watch-glass nails. Other remarkable findings were: surgical closure of a patent arterial duct, decreased knee-mobility and consanguineous parents. This combination is suggestive for primary hypertrophic osteoarthropathy (PHO; #OMIM 259100). Read More

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December 2018
8 Reads

Digital clubbing: A patient with hypertrophic osteoarthropathy and the presence of acro-osteolysis.

Reumatol Clin 2017 Dec 29. Epub 2017 Dec 29.

Unidad de Cuidados Críticos Urgente, San Fernando-Cádiz, San Fernando, Cádiz, España.

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December 2017
8 Reads