Search Our Scientific Publications & Authors

J Burn Care Res 2019 Apr 16. Epub 2019 Apr 16.

Section of Plastic and Reconstructive Surgery The Burn and Complex Wound Center The University of Chicago Medicine Chicago, IL.

Introduction: Under ideal circumstances, severely frostbitten extremities are rapidly rewarmed and treated with thrombolytic therapy within 6-24 hours. In an "inner city," urban environment, most patients who suffer frostbite injuries present in a delayed fashion, sustain repeated injuries further complicated by psychological issues or intoxication, and are rarely ideal candidates for thrombolytic therapy within the prescribed timeframe. We describe our experience with the treatment of urban frostbite injuries. Read More

Adv Skin Wound Care 2019 Apr;32(4):183-189

In Seoul, South Korea, Yeseul Eom, MD, is a resident in the Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; and Kyong-Je Woo, MD, PhD, is an assistant professor, Department of Plastic Surgery, Mokdong Hospital, College of Medicine, Ewha Womans University. Acknowledgments: This work was supported by the Ewha Womans University Research Grant of 2017.

Objective: To evaluate the effectiveness of negative-pressure wound therapy (NPWT) for management of wound complications at extracorporeal membrane oxygenation (ECMO) removal sites.

Methods: The authors retrospectively reviewed patients who underwent NPWT at ECMO removal sites followed by the development of wound complications including skin necrosis, lymphorrhea, and femoral vessel exposure. A nonadhesive bacteria-binding mesh was used as a wound contact layer of NPWT application. Read More

World Neurosurg 2019 Mar 24;123:323-327. Epub 2018 Dec 24.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, The National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.

Background: Isolated cervical pseudoaneurysms of the internal carotid artery (ICA) in patients with Marfan syndrome are extremely rare.

Case Description: A 73-year-old female with Marfan syndrome and history of multiple aortic aneurysms presented to an outside hospital with dysphagia, a mass in her neck, dizziness, nausea, and vomiting. A computed tomography angiogram showed bilateral cervical ICA pseudoaneurysms, more significant on the right side. Read More

Cureus 2018 Sep 17;10(9):e3319. Epub 2018 Sep 17.

Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, USA.

Background: Hidradenitis suppurativa (HS) is a physically debilitating disease that greatly impairs the quality of life of affected individuals. Advanced disease is often difficult to treat with topical and systemic therapies. Surgical resection of diseased skin has become paramount in HS management but proposes challenges of wound care and closure. Read More

Eur Arch Otorhinolaryngol 2018 Dec 13;275(12):2975-2981. Epub 2018 Oct 13.

Department of Otorhinolaryngology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, 35170, Izmir, Turkey.

Objectives: To compare the anatomical and functional outcomes of two different grafts which are used for the reconstruction of subtotal or total tympanic membrane perforations: the wheel-shaped composite cartilage graft (WsCCG) and temporalis fascia (TF).

Methods: Ninety patients (94 ears) who underwent type 1 tympanoplasty for non-complicated chronic otitis media between March 2014 and June 2016 in a tertiary referral center were included in a randomized, controlled, prospective clinical trial. Tympanic membranes were reconstructed with the WsCCG or TF. Read More

World Neurosurg 2018 Dec 24;120:e497-e502. Epub 2018 Aug 24.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

Objective: To describe the incidence of and characterize risk factors for cerebrospinal fluid leak and symptomatic pseudomeningocele (CSFL/SP) after intradural spine surgery.

Methods: A retrospective analysis of a prospectively collected and consecutive series of patients undergoing intradural spine surgery by the senior author (A.D. Read More

Adv Drug Deliv Rev 2018 Aug 11. Epub 2018 Aug 11.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB Nijmegen, The Netherlands. Electronic address:

The healing of skeletal muscle injuries after major trauma or surgical reconstruction is often complicated by the development of fibrosis leading to impaired function. Research in the field of muscle regeneration is mainly focused on the restoration of muscle mass while far less attention is paid to the prevention of fibrosis. In this review, we take as an example the reconstruction of the muscles in the soft palate of cleft palate patients. Read More

Adv Wound Care (New Rochelle) 2018 Jul;7(7):209-231

European Molecular Biology Laboratory Australia, Australian Regenerative Medicine Institute, Monash University, Victoria, Australia.

The immune system plays a central role in orchestrating the tissue healing process. Hence, controlling the immune system to promote tissue repair and regeneration is an attractive approach when designing regenerative strategies. This review discusses the pathophysiology of both acute and chronic wounds and possible strategies to control the immune system to accelerate chronic wound closure and promote skin regeneration (scar-less healing) of acute wounds. Read More

Am Surg 2018 Jun;84(6):938-946

Postoperative surgical site infections (SSIs) are one of the most common complications. SSIs after laparotomy have a high incidence and are complicated and expensive to heal. The aim of this study was to evaluate the safety and efficacy of a novel therapy of early closure of open abdominal SSIs wound combining wound irrigation with negative pressure wound therapy (NPWT). Read More

BMC Surg 2018 Jun 15;18(1):41. Epub 2018 Jun 15.

Department of Digestive and General Surgery, Shimane University Faculty of Medicine, 89-1, Enyacho, Izumo, Shimane, 693-8501, Japan.

Background: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound. Read More

Vet Comp Orthop Traumatol 2018 Jul 11;31(4):229-238. Epub 2018 Jun 11.

Department for Clinical Veterinary Medicine, Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians University, Munich, Bayern, Germany.

Objectives:  To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.

Study Type:  Prospective randomized clinical study MATERIALS AND METHODS:  Dogs ( = 26) undergoing open-wound treatment were randomly assigned to one of two groups: Group A ( = 13) NPWT; Group B ( = 13) silver-coated foam dressing. Pairs of patients were matched based on wound conformation, localization, and underlying cause and compared in terms of duration of previous treatment, development of wound size (wound planimetry), time to closure, bacterial bio-burden and complications. Read More

Int Wound J 2018 Oct 5;15(5):749-755. Epub 2018 Jun 5.

Centre of Excellence in Biofilm Science and Technologies (CEBST), 5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, Liverpool, UK.

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or chronic wounds show clinical signs of delayed healing, persistent inflammation, and the production of non-viable tissue. Read More

Wounds 2018 Jan;30(1):E1-E4

General Surgery Department, Hospital de Braga, Braga, Portugal; and Surgical Sciences Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.

Introduction: Performing surgery on patients with Crohn's disease is a true challenge due to the elevated risk of complications related to the chronic proinflammatory response. Stenosis is the leading cause of intestinal resection in these patients.

Case Report: The authors present the case of a 50-year-old woman with inflammatory stenosis of the terminal ileum due to Crohn's disease. Read More

Medicine (Baltimore) 2017 Dec;96(52):e9370

Department of Dermatology.

Rationale: An open abdomen complicated with small-bowel fistulae becomes a complex wound for local infection, systemic sepsis and persistent soiling irritation by intestinal content. While controlling the fistulae drainage, protecting surrounding skin, healing the wound maybe a challenge.

Patient Concerns: In this paper we described a 68-year-old female was admitted to emergency surgery in general surgery department with severe abdomen pain. Read More

Expert Rev Med Devices 2018 Feb 18;15(2):145-155. Epub 2018 Jan 18.

c Chairman, Division of Orthopaedic Surgery , Albany Medical Center , Albany , NY, USA.

Introduction: Acute traumatic or surgical wounds that cannot be primarily closed often cause substantial morbidity and mortality. This often leads to increased costs from higher material expenses, more involved nursing care, and longer hospital stays. Advancements in soft tissue expansion has made it a popular alternative to facilitate early closure without the need for more complicated plastic surgical procedures. Read More

J Foot Ankle Surg 2018 May - Jun;57(3):456-461. Epub 2017 Dec 19.

Third-Year Resident, Foot and Ankle Surgery Residency Program, Regions Hospital/HealthPartners Institute for Education and Research, St. Paul, MN. Electronic address:

Distal hallux gangrene and neuropathic ulceration associated with digit deformity frequently result in osteomyelitis of the distal phalanx. Ideal treatment would involve limited resection to preserve function. We describe our surgical technique and retrospective results for distal Syme hallux amputation with plantar flap closure. Read More

Int Ophthalmol 2019 Jan 19;39(1):225-230. Epub 2017 Dec 19.

First Department of Ophthalmology, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Purpose: To describe the use of equine pericardium as an off-label temporary emergency treatment of scleral and corneal perforations.

Methods: Three eyes of two male patients aged 34 and 38 years were included, i.e. Read More

J Wound Care 2017 Dec;26(12):712-719

Trauma and Orthopaedic Consultant, Broomfield Hospital, Chelmsford, UK.

Objective: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Read More

Wounds 2017 Nov;29(11):E111-E114

Osiris Therapeutics, Inc, Columbia, MD.

Introduction: Repair of acute Achilles tendon ruptures is complicated by the severity of the rupture, quality of the tendon, and length of the defect. The adjunct use of biologics (eg, viable umbilical tissue) may provide additional support and reduce postoperative inflammation, adhesions, and fibrosis.

Objective: The aim of this study is to review the outcomes of Achilles tendon rupture open repairs with viable cryopreserved umbilical tissue (vCUT) compared with patients treated with standard of care only. Read More

J Wound Care 2017 Nov;26(11):680-690

Professor, Institute for Wound Research, Department Obstetrics and Gynaecology, University of Florida, Gainesville, US.

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and dispersants in the cosmetics, hygiene, food and oil industries. Their use in a clinical setting is also common, particularly within the field of wound care. Many wound cleansers contain surfactants and subsequently there is available data that shows the growing potential of these wound cleansers in the enhancement of wound closure. Read More

Int J Surg Case Rep 2017 4;41:174-179. Epub 2017 Oct 4.

Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. Electronic address:

Introduction: Charcot Neuroarthropathy is a complex lower extremity pathology which predisposes the afflicted limb to ulcerations, osteomyelitis, and risk of major amputation. Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection. When soft tissue and osseous deficits must be concomitantly addressed, the use of PMMA spacers can be combined with free tissue transfers. Read More

J Craniofac Surg 2018 Jan;29(1):e31-e33

Department of Dental and Prosthetic Surgery, Tata Memorial Hospital, Mumbai, India.

Intraoral defects secondary to resection of mandible leading to mandibular discontinuity are very complicated to treat as the muscles exert forces on the residual portion of the mandible. Primarily this leads to disfigurement of the face. These forces also make mastication difficult due to imbalance. Read More

J Craniomaxillofac Surg 2017 Oct 27;45(10):1724-1730. Epub 2017 Jul 27.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Germany.

Background: Compromised wound healing in cranio-maxillo-facial surgery is a threat to the patient's rehabilitation. Therapy of chronic and/or infected wounds is time- and cost-consuming, burdensome and occasionally futile. Cold atmospheric plasma is a new approach that promises to overcome these limitations. Read More

World Neurosurg 2017 Nov 18;107:522-525. Epub 2017 Aug 18.

Department of Neurological Surgery, Spine Research Group, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:

Background: Durotomies are not infrequent in spine surgery and have increased complication rates. Primary repair is the gold standard and is feasible when access is not limited by the anatomy. A patient who presented 1 week after spinal fusion with cerebrospinal fluid (CSF) leak underwent a novel transthecal approach to repair an anterior dural tear. Read More

Wounds 2017 Jul;29(7):202-208

Plastic & Aesthetic Surgery Center, Peking Union Medical College Hospital, Beijing, China.

The combination of open abdominal wounds and intra-abdominal infections is challenging to treat and often results in critical illness associated with high mortality.

Objective: The aim of this study is to evaluate the feasibility of using negative pressure wound therapy (NPWT) to manage complex abdominal wounds and summarize relevant treatment experiences.

Materials And Methods: A retrospective analysis of records from April 2012 to May 2015 identified 13 hospitalized patients with open abdominal wounds complicated by intra-abdominal infections. Read More

J Surg Case Rep 2017 Jul 4;2017(7):rjx122. Epub 2017 Jul 4.

General Surgery Service (Extradigestive Unit), Department of Surgery, Santo António Hospital-Oporto Hospital Centre, Oporto, Portugal.

Management of complicated wounds is a challenge in head and neck reconstruction. Although the negative pressure wound therapy or wound vacuum-assisted closure has been widely used in complicated wounds and shows promising results, its application in the head and neck region after reconstruction for the head and neck cancer is rarely presented. A 77-year-old woman underwent a radical resection of an extensive basal cell carcinoma of the scalp and forehead involving the periosteum, where classic reconstruction was difficult, but successfully treated with negative pressure wound therapy. Read More

Otolaryngol Head Neck Surg 2017 12 4;157(6):1025-1033. Epub 2017 Jul 4.

2 Department of Otolaryngology-Head and Neck Surgery, Naval Medical Center San Diego, San Diego, California, USA.

Objectives To assess outcomes following tympanoplasty for blast-induced tympanic membrane perforations in a military population. Study Design Case series with chart review. Setting Tertiary care medical centers. Read More

Ostomy Wound Manage 2017 Jun;63(6):34-38

Necrotizing enterocolitis (NEC) is the most common surgical emergency in neonatal intensive care units, and patients who require surgery have high mortality and morbidity rates. The utility of negative pressure in the management of adults with complicated abdominal wounds has been documented, but there are few reports describing the use of negative pressure wound therapy (NPWT) in children or following neonatal surgery. The case of a 6 day old, 5-weeks premature neonate with NEC is presented. Read More

NPJ Biofilms Microbiomes 2017 11;3. Epub 2017 Apr 11.

School of Systems Biology, George Mason University, Manassas, VA 20110 USA.

Cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. We have identified a histone H1-derived peptide from the Komodo dragon (, called VK25. Using this peptide as inspiration, we designed a synthetic peptide called DRGN-1. Read More

Acta Ophthalmol 2017 Sep 20;95(6):639-642. Epub 2017 Jun 20.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To assess the surgical and functional outcome of internal direct cyclopexy as therapy of complicated traumatic cyclodialysis.

Methods: The single-centre interventional case-series study included eyes with traumatic cyclodialysis who had consecutively been treated. Internal cyclopexy was performed using double-armed sutures introduced into the eye through the pars plana opposite to the cyclodialysis cleft and which were laid parallel to limbus. Read More

J Wound Care 2017 Jun;26(6):342-345

Koç University School of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul, Turkey.

Adams-Oliver syndrome is a rare disorder with varying degrees of scalp and cranial bone defects as well as limb anomalies, which can range from mild to more pronounced manifestations. In mild cases, closure of these defects can be achieved with a conservative approach. However, surgical closure is recommended in cases where the defect is extensive and includes cranial involvement. Read More

Eur J Obstet Gynecol Reprod Biol 2017 Jun 5;213:26-30. Epub 2017 Apr 5.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel(2). Electronic address:

Background: Urinary bladder injury is a rare complication during cesarean delivery. Little is known on maternal outcome following this injury.

Objective: To evaluate short and long-term maternal outcome following bladder injury during cesarean delivery. Read More

Eplasty 2017 21;17:e10. Epub 2017 Mar 21.

Institute for Plastic Surgery, Southern Illinois University School of Medicine, Springfield, IL.

Postsurgical pyoderma gangrenosum is a rare but potentially devastating condition for surgical patients. While pyoderma gangrenosum has 2 subtypes, typical and atypical, each can be further classified by its heralding features. These include ulcerative, pustular, bullous, and vegetative. Read More

Echocardiography 2017 Jun 31;34(6):939-941. Epub 2017 Mar 31.

Cardiology Department, Hospital do Espirito Santo, Evora, Portugal.

Left atrial dissection is a rare entity, mostly occurring after mitral valve surgery, with only a few cases described after myocardial infarction. The authors report a case of a 60-year-old man who presented with an inferior myocardial infarction, complicated with pseudoaneurysm of basal segment of left ventricular inferior wall, which expanded through the mitral ring to left atria, causing left atrial free wall dissection. The left ventriculo-atrial communication through the pseudoaneurysm caused major para-mitral regurgitation and the development of acute heart failure. Read More

Laryngoscope 2017 08 14;127(8):1767-1771. Epub 2017 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.

Objectives/hypothesis: To present a novel technique for the repair of large complicated nasal septal perforations using an upper lateral cartilage composite flap.

Study Design: This is a case series of five patients with large septal perforations seen at an academic tertiary care center, who have failed previous treatment measures and were selected to undergo this novel reconstruction for closure of their defects.

Methods: Patients were followed clinically to determine the success of the repair. Read More

PLoS Negl Trop Dis 2017 02 28;11(2):e0005331. Epub 2017 Feb 28.

Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Background: Beyond Mycobacterium ulcerans-specific therapy, sound general wound management is required for successful management of Buruli ulcer (BU) patients which places them among the large and diverse group of patients in poor countries with a broken skin barrier.

Methods: Clinically BU suspicious patients were enrolled between October 2013 and August 2015 at a primary health care (PHC) center and a municipal hospital, secondary health care (SHC) center in Ghana. All patients were IS2404 PCR tested and divided into IS2404 PCR positive and negative groups. Read More

Eplasty 2017 25;17:e2. Epub 2017 Jan 25.

We describe a novel technique of contralateral pedicled deepithelialized superficial inferior epigastric artery flaps, followed by abdominal advancement coverage, as an alternative treatment of radiated complicated inguinal or lower abdominal defects, avoiding the donor-site defect typically seen with other methods of coverage. Two male patients with histories of liposarcoma after excision and radiation to one side of lower abdomen/inguinal area presented with complicated wounds that were reconstructed with this technique. Successful obliteration of dead space and wound closure were achieved with the combination of a superficial inferior epigastric artery flap with an abdominal advancement flap. Read More

Orthopade 2017 Apr;46(4):342-352

Klinik für Handchirurgie, Salzburger Leite 1, 97616, Bad Neustadt an der Saale, Deutschland.

Background: The tendency of recurrence or progression is a frequent problem in Dupuytren's disease. The management of recurrence is adapted to the individual situation and the patient's needs. In mild cases a non-operative approach is recommended. Read More

Stomatologiia (Mosk) 2016;95(6):36-39

Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health, Moscow, Russia an Federation.

The purpose of the message was the comparison of change in the width and quality of keratinized tissue created in the lower vestibuloplasty area. Preliminary results of the case-control study involving 71 patients showed that autotransplantation managed to create the necessary buffer zone with the desired thickness of the mucosa and is particularly justified in cases of «washing board effect». However, the method is technically complicated and more expensive and painfull for patients. Read More

J Med Case Rep 2017 Jan 23;11(1):22. Epub 2017 Jan 23.

Department of Ophthalmology, Military Institute of Medicine, 128 Szaserów St., 04-141, Warsaw, Poland.

Background: A cyclodialysis cleft is a gap resulting from disruption of the longitudinal fibers constituting the ciliary body attachment to the scleral spur. The cyclodialysis cleft can be of traumatic or iatrogenic origin, and it may occur during intraocular surgery or as a result of a glaucoma operation. In this report we present a surgical technique to treat cyclodialysis: cyclopexy combined with phacoemulsification subluxation lens, transscleral suturing of Cionni ring, and intraocular lens implantation with iris cerclage suture. Read More

Afr J Paediatr Surg 2016 Oct-Dec;13(4):185-188

Department of Surgery, Division of Paediatric Surgery, National Hospital, Abuja, Nigeria.

Background: Primary wound closure following laparotomy for peritonitis is generally believed to be associated with wound complications and long hospital stay. Open wound management has long been the most common practice after laparotomy for peritonitis. Primary closure (PC), however, has recently been advocated to reduce cost and morbidity. Read More

Cureus 2016 Nov 14;8(11):e877. Epub 2016 Nov 14.

Section of Plastic Surgery VA Healthcare - San Diego, Division of Plastic Surgery University of California San Diego.

Complex pressure ulcer wound sites often present with a wide scope of barriers to healing ranging from high colonization of multi-drug-resistant pathogens to tortuous internal anatomy which make the wound recalcitrant to traditional wound care including standard negative pressure wound therapy (NPWT). Negative pressure wound therapy with instillation (NPWTi-d) provides an opportunity to manage and heal wounds with indications not met by standard NPWT such as cavitating wounds with complex undermining and tunneling. In this clinical case report, a patient who presented with a chronic, non-healing Stage IV pressure ulcer underwent a tensor fascia lata flap reconstruction that was complicated by a partial flap-tip nonadherence with associated partial dehiscence of the flap incision that proved unresolvable until application of adjunctive NPWTi-d which allowed the wound to experience a robust rate of granulation, contraction, and closure. Read More

J Foot Ankle Surg 2016 Nov - Dec;55(6):1148-1157. Epub 2016 Sep 1.

Fellowship Trained Foot and Ankle Surgeon, Jamestown Regional Medical Center, Jamestown, ND.

Nonhealing wounds along the fifth metatarsal associated with neuropathy and bone deformity frequently become complicated with osteomyelitis. Our surgical technique for complete fifth ray amputation with peroneal tendon transfer has been previously published. The present study evaluated the outcomes regarding success with initial healing and intermediate-term limb survival after this procedure, which is intended to resolve infection, remove bone deformity, heal and prevent recurrence of lateral column wounds, and maintain functional stability of the foot. Read More

Biomed Pharmacother 2016 Dec 14;84:878-891. Epub 2016 Oct 14.

Enzymes and Bioconversion Research Unit, Department of biological engineering, National School of Engineers of Sfax (ENIS), BP W, 3038 Sfax, Tunisia; Higher Institute of Biotechnology of Sfax (ISBS), BP 261, 3000 Sfax, Tunisia. Electronic address:

Background: Lipopeptide microbial surfactants are endowed with unique surface properties as well as antimicrobial, anti-wrinkle, moisturizing and free radical scavenging activities. They were introduced safely in dermatological products, as long as they present low cytotoxicity against human cells. The present study was undertaken to evaluate the in vitro antioxidant activities and the wound healing potential of Bacillus subtilis SPB1 lipopeptide biosurfactant on excision wounds induced in experimental rats. Read More

Cornea 2016 Dec;35(12):1516-1519

*Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel;†Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;‡Department of Ophthalmology, "Villa Igea" Hospital, Forlì, Italy; and§Istituto internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy.

Purpose: To report the use of Descemet stripping automated endothelial keratoplasty (DSAEK) for treatment of sterile corneal perforations accompanying endothelial decompensation.

Methods: In this multicenter interventional case series, we reviewed the medical records of all tectonic DSAEK surgeries performed at Villa Serena-Villa Igea private Hospitals (Forlì, Italy) and Rabin Medical Center (Petach Tikva, Israel) between January 2014 and March 2016.

Results: Three patients with endothelial decompensation and sterile corneal perforation (n = 2) or impending corneal perforation (n = 1) underwent DSAEK between 2014 and 2015 at Villa Igea Hospital, Forlì, Italy, and Rabin Medical Center, Petach Tikva, Israel. Read More

Am J Case Rep 2016 Oct 11;17:730-733. Epub 2016 Oct 11.

Department of Burns, Changhai Hospital, Second Military Medical University, Shanghai, China (mainland).

BACKGROUND As patients with thoracic duct injuries often suffer from severe local soft tissue defects, integrated surgical treatment is needed to achieve damage repair and wound closure. However, thoracic duct chylous fistula is rare in burn patients, although it typically involves severe soft tissue damage in the neck or chest. CASE REPORT A 32-year-old male patient fell after accidentally contacting an electric current (380 V) and knocked over a barrel of sulfuric acid. Read More

Wounds 2016 Sep;28(9):317-327

Homecare Service, Israel Cancer Association and Geriatric-Palliative Service, Wolfson Medical Center, Holon, Israel.

Introduction: The objective of this pilot study was to evaluate the efficacy and safety of a novel method using an autologous whole blood clot formed with the RedDress Wound Care System (RD1, RedDress Ltd, Israel), a provisional whole blood clot matrix used in the treatment of chronic wounds of various etiologies.

Methods And Materials: Patients were treated at the bedside with the whole blood clot matrix. Blood was withdrawn from each patient using citrate, mixed with a calcium gluconate/kaolin suspension, and injected into an RD1 clotting tray. Read More

Int J Radiat Biol 2017 03 21;93(3):340-350. Epub 2016 Oct 21.

a Cytori Therapeutics Inc , San Diego , CA , USA.

Purpose: To develop an approach that models the cutaneous healing that occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of the effects of an autologous cell therapy on wound healing on thermal burn injury with concomitant radiation exposure was used to validate the utility of the model.

Methods: Göttingen minipigs were subjected to a 1. Read More

J Clin Aesthet Dermatol 2016 Aug 1;9(8):47-9. Epub 2016 Aug 1.

Webster Management, Inc. (Private Practice), Oakland, California.

Objective: Following Mohs surgery, medium-to-large defects on the central forehead can often be complicated to surgically reconstruct. In this paper, the authors discuss possible central forehead reconstructions and report their successful experience employing a simple primary vertical linear closure with a special technique to demarcate forehead rhytides rather than performing an overly complicated flap or graft.

Case Report: The patient was a 57-year-old man who presented with a broad superficial basal cell carcinoma that required treatment with Mohs surgery. Read More

Wounds 2016 Aug;28(8):255-63

Department of Burns and Reconstructive Surgery, Comenius University and University Hospital Ružinov, Bratislava, Slovak Republic.

Unlabelled: Although negative pressure wound therapy (NPWT) has been used for more than 20 years, as far as the authors are aware, there is little research aimed at the evaluation of the combination of NPWT with a silver-impregnated dressing.

Objective: The aim of this study was to examine the effect, efficacy, and safety of NPWT in conjunction with a silver-impregnated dressing.

Materials And Methods: The authors used a retrospective study of 54 acute and chronic wounds treated in 50 patients over a 2-year period. Read More