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Int Orthop 2020 May 30. Epub 2020 May 30.

Department of Orthopaedic Surgery and Traumatology, Ghent University Hospital, 10 C. Heymanslaan, Entrance 75, Route 740, 9000, Ghent, East Flanders, Belgium.

Purpose: Adequate exposure in revision of total shoulder arthroplasty (TSA) is important for optimal prosthesis placement and functional results. A clavicular osteotomy in difficult cases of revision TSA is a useful surgical technique that increases the superior exposure area, provides safer dissection, minimizes damage to the anterior deltoid muscle, improves glenoid access, and allows for superior dislocation of the humeral component. There is a paucity of literature analyzing the clavicular osteotomy during challenging cases of revision TSA. Read More

J Adhes Dent 2020 ;22(3):249-254

Purpose: The management of complicated crown-root fractures is challenging for endodontic restoration. The present case describes a patient who sustained trauma to the maxillary right central incisor.

Materials And Methods: Clinical and radiographic examination showed a complicated crown-root fracture and incomplete root development with periapical radiolucency and inadequate endodontic treatment with overfilling. Read More

Int J Low Extrem Wounds 2020 May 7:1534734620919315. Epub 2020 May 7.

Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Total knee replacement arthroplasty is a common procedure and postoperative wound complications are sometimes inevitable. Although invasive reconstructive surgery may be an option for nonhealed wounds, such procedures can limit early rehabilitation, adversely affecting the range of joint motion. Patients can achieve a wider range of motion if they undergo early rehabilitation with a conservative approach. Read More

Wounds 2020 Mar;32(3):E14-E18

Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.

Introduction: Diabetic foot ulcers may lead to nontraumatic amputations of the foot, leading to a decrease in patient quality of life. Transmetatarsal amputations (TMAs) represent an effective surgical procedure in cases of severe foot infection, but the tissue reconstruction is complicated and additional procedures should be considered. The present case report evaluates the wound closure of an open TMA in a patient with diabetes treated with a new aerogel composed of chitosan (ChS) and chondroitin sulphate (CS), without needing a skin graft. Read More

Plast Reconstr Surg Glob Open 2020 Jan 24;8(1):e2604. Epub 2020 Jan 24.

Department of Surgery, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Managing cavity wounds that cannot be cleaned using standard irrigating solution is challenging. An immunocompromised patient with a horseshoe perianal abscess was selected to represent a heavy infection in cavity wounds. Diluted povidone-iodine was initially used to lavage the wounds, but the fever persisted and the irrigation was painful. Read More

Injury 2020 Feb 11. Epub 2020 Feb 11.

Department of Traumatology, University of Szeged, Hungary.

Diabetes is a common disease that potentially interferes with healing processes after lower limb trauma. In our presented case a trimalleolar ankle fracture with undiscovered serious soft-tissue injuries resulted in chronic soft-tissue complications in a diabetic patient, requiring three and a half months of hospitalization in a higher level center and the application of state-of-the-art wound treatment, including vacuum-assisted closure therapy, Integra bioengineered skin substitute, split-thickness skin-grafting, and methods enhancing wound healing, such as polarized light therapy and transdermal CO delivery. The presented case emphasizes the importance of soft-tissue care and multidisciplinary approach in diabetic trauma patients with poor compliance. Read More

ACS Nano 2020 03 17;14(3):3299-3315. Epub 2020 Feb 17.

Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Due to the inability to spontaneously heal and vulnerability to bacterial infection, diabetic patients are frustrated by unexpected epithelium injuries in daily life. Notably, a drug-resistant bacterial infection may result in a long-term impact to the natural function of damaged organs. It is imperative to develop strategies that promote injury recovery and eradicate drug-resistant infection simultaneously. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Dec;44(12):1385-1390

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To study the methods and principles for simultaneous treatment in the children with pectus excavatum (PE) combined with congenital cardiothoracic diseases.
 Methods: The medical records of all children, who underwent simultaneous repair of PE combined with congenital cardiothoracic diseases, were retrospectively reviewed in Hunan Children's Hospital from January 2007 to September 2018. The patients were divided into a PE combined with congenital heart disease (CHD) group (n=17) and a PE combined with thoracic disease group (n=10). Read More

Int J Surg Case Rep 2020 26;66:322-325. Epub 2019 Dec 26.

Division of Plastic Surgery, Department of General Surgery and Surgical Specialties. University of Modena and Reggio Emilia, Via Largo del Pozzo 71, 41124 Modena, Italy. Electronic address:

Introduction: Multiple surgical debridement sessions are mandatory before wound closure in cases of infection after a modified Ravitch procedure for pectus excavatum. Vacuum-assisted closure (VAC) is a well-established technical resource for treating complicated wounds; however, in cases of suspicion of bone infection, this approach is not enough to prevent bar removal.

Presentation Of The Case: We present a case of surgical wound dehiscence with hardware exposure in a patient who had undergone chondrosternoplasty for pectus excavatum. Read More

Urology 2020 Mar 27;137:146-151. Epub 2019 Dec 27.

Division of Pediatric Urology, James Buchanan Brady Urological Institutions, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Charlotte Bloomberg Children's Hospital, Baltimore, MD. Electronic address:

Objective: To explore a series of classic bladder exstrophy (CBE) cases referred to the authors' institution where primary closure with penile disassembly epispadias repair was complicated by penile injury. The penile disassembly technique is frequently combined with bladder closure in patients with CBE undergoing the complete primary repair of exstrophy (CPRE). Penile disassembly has been posited as a risk for penile injury by ischemic mechanisms. Read More

J Biomed Mater Res A 2020 Mar 20;108(3):545-556. Epub 2019 Nov 20.

Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Wound healing is known as one of the most complicated biological processes for injured skin caused by surgical, trauma, burns, or diabetic diseases, which causes a nonfunctioning mass of fibrotic tissue. Recent reports have suggested that exosomes (EXOs) secreted by this type of stem cells may contribute to their paracrine effect. In this study, the EXOs were isolated from the supernatant of cultured adipose-derived stem cells (ADSCs) via ultracentrifugation and filtration. Read More

Int Wound J 2020 Apr 6;17(2):251-258. Epub 2019 Nov 6.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Asia University Hospital, Asia University College of Medical and Health Science, Taichung, Taiwan.

Fistula formation in head and neck wounds is considered one of the most challenging complications that a head and neck reconstructive surgeon may encounter. The current mainstay of treatment is aggressive surgical debridement followed by vascularised soft tissue coverage. Negative pressure wound therapy (NPWT) has been successfully used for the closure of complicated wounds for decades. Read More

BMJ Case Rep 2019 Aug 30;12(8). Epub 2019 Aug 30.

Department of Surgery, Eastern Health, Box Hill, Victoria, Australia.

A 63-year-old man with a history of gastro-oesophageal reflux disease underwent defunctioning loop ileostomy for obstructing metastatic rectal cancer prior to receiving long-course neoadjuvant chemoradiotherapy. Four months post completion of neoadjuvant therapy, he underwent an uncomplicated elective ultra-low anterior resection with formation of colonic J pouch and first stage liver metastasectomy for bilobar liver disease. At 1 year, he proceeded to an elective closure of loop ileostomy. Read More

Diabetes 2019 11 22;68(11):2175-2190. Epub 2019 Aug 22.

Indiana Center for Regenerative Medicine and Engineering, Indiana University Health Comprehensive Wound Center, Indiana University School of Medicine, Indianapolis, IN

Epithelial to mesenchymal transition (EMT) and wound vascularization are two critical interrelated processes that enable cutaneous wound healing. Zinc finger E-box binding homeobox 1 (ZEB1), primarily studied in the context of tumor biology, is a potent EMT activator. ZEB1 is also known to contribute to endothelial cell survival as well as stimulate tumor angiogenesis. Read More

Tech Coloproctol 2019 Aug 20;23(8):751-759. Epub 2019 Aug 20.

Department of Surgery, Amsterdam University Medical Centres, University of Amsterdam, Meibergdreef 9, Post Box 22660, 1100 DD, Amsterdam, The Netherlands.

Background: Abdominoperineal resection (APR) carries a high risk of perineal wound morbidity. Perineal wound closure using autologous tissue flaps has been shown to be advantageous, but there is no consensus as to the optimal method. The aim of this study was to evaluate the feasibility of a novel gluteal turnover flap (GT-flap) without donor site scar for perineal closure after APR. Read More

World Neurosurg 2019 Dec 14;132:e710-e715. Epub 2019 Aug 14.

Department of Neurosurgery, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Background: Dural reconstruction after transpetrosal approaches is complicated because complete primary closure of presigmoid dura mater is difficult to achieve. To address this problem, we use biocompatible polyglycolic acid (PGA) felt (Durawave) to reconstruct dural defects. To evaluate the use of PGA felt in dural reconstruction, we compared these results with those after conventional duraplasty using autologous fascia grafts. Read More

BMC Cardiovasc Disord 2019 08 14;19(1):196. Epub 2019 Aug 14.

Heart Center, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Left atrial appendage closure is increasingly used. LAA closure procedures can rarely be complicated by device embolization, typically towards the aorta. In this case report, we describe the successful percutaneous retrieval of an embolized Amulet device from the left atrium in a patient with previous MitraClips. Read More

Wound Repair Regen 2019 11 19;27(6):680-686. Epub 2019 Aug 19.

Research & Development, TissueTech, Inc., Miami, Florida.

Clinical trials of potential new therapies for diabetic foot ulcers rarely enroll patients whose wounds extend to muscle, fascia, or bone with clinical and radiographic evidence of underlying osteomyelitis. An open-label, multicenter trial of cryopreserved human umbilical cord (TTAX01) was undertaken in 32 subjects presenting with such complex wounds with a mean duration of 6.1 ± 9. Read More

Sci Adv 2019 07 24;5(7):eaaw3963. Epub 2019 Jul 24.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Inspired by embryonic wound closure, we present mechanically active dressings to accelerate wound healing. Conventional dressings passively aid healing by maintaining moisture at wound sites. Recent developments have focused on drug and cell delivery to drive a healing process, but these methods are often complicated by drug side effects, sophisticated fabrication, and high cost. Read More

Contemp Oncol (Pozn) 2019 27;23(2):69-73. Epub 2019 May 27.

Chair of Surgery and Oncology, Clinic of General Surgery and Surgical Oncology, Faculty of Medicine and Health Sciences, University of Zielona Gora, Poland.

Negative-pressure wound therapy (NPWT) is used to treat many different types of wounds, but there is still a lack of large studies describing its effectiveness in breast surgery. Enhanced recovery, reduction of complications, and good scar quality might be improved by the application of NPWT. Existing data show that vacuumassisted closure (VAC) application after expander-based breast reconstruction may be beneficial because of decreasing overall complications in comparison with standard wound treatment. Read More

FASEB J 2019 09 5;33(9):9858-9870. Epub 2019 Jun 5.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Wound healing, especially for diabetic wounds, is a lengthy and complicated process involving interactions and responses at the protein, cell, and tissue levels. Loading of growth factors into a hydrogel to construct a sustained-release system is considered a promising approach to improve wound healing. The present study investigates the effect of thermosensitive heparin-poloxamer (HP) hydrogel-encapsulated recombinant human fibroblast growth factor 21 (rhFGF21) on wound healing in mice with streptozotocin-induced diabetes mellitus. Read More

J Reconstr Microsurg 2019 Oct 14;35(8):616-621. Epub 2019 May 14.

Division of Plastic and Reconstructive Surgery, Louisiana State University School of Medicine, New Orleans, Louisiana.

Background:  Despite the landmark study by Godina 30 years ago, opinions still vary within the literature about the management of complex traumatic wounds in the lower extremity. We present a large series of lower extremity reconstructions with vascularized free tissue and examine the perioperative factors that influenced the success of these cases.

Methods:  We reviewed 88 patients with free flap reconstruction of traumatic lower extremity wounds over 8 years. Read More

Adv Skin Wound Care 2019 May;32(5):234-237

In the Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Daryoush Hamidi Alamdari, PhD, is Associate Professor of Biochemistry; Mohamad Reza Motie, MD, is Associate Professor of Surgery; Nasim Kamalahmadi, MD, is a Medical Practitioner; and Mohsen Aliakbarian, MD, is Associate Professor of Surgery. Acknowledgments: The authors thank the patients who participated in the study and Ms M. Hassanpour for editing the manuscript. The study was supported by the Vice Chancellor for Research of Mashhad University of Medical Sciences (grant 88529). The authors have disclosed no other financial relationships related to this article. Submitted April 24, 2018; accepted in revised form June 8, 2018.

Background: Pilonidal sinus is one of the most complicated chronic wounds common in younger adults. This disabling condition affects the natal clefts of the buttocks and often requires surgery.

Objective: To investigate the effect of autologous platelet-rich plasma and fibrin glue (PRP-FG) on pain reduction and the healing process of pilonidal sinus after excisional surgery with primary closure. Read More

J Burn Care Res 2019 08;40(5):613-619

The Burn and Complex Wound Center, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medicine, Illinois.

Under ideal circumstances, severely frostbitten extremities are rapidly rewarmed and treated with thrombolytic therapy within 6 to 24 hours. In an "inner city," urban environment, most patients who suffer frostbite injuries present in a delayed fashion, sustain repeated injuries further complicated by psychological issues or intoxication, and are rarely ideal candidates for thrombolytic therapy within the prescribed timeframe. We describe our experience with the treatment of urban frostbite injuries. Read More

Acta Biomed 2019 01 18;90(1):116-121. Epub 2019 Jan 18.

Azienda Ospedaliera Universitaria Integrata di Verona.

Fractures of the acetabulum are rare in the pediatric age and may be complicated by the premature closure of the triradiate cartilage. We report a case of triradiate cartilage displaced fracture treated surgically. A 14 years old boy, following a high-energy road trauma, presented an hematoma in the right gluteal region with severe pain. Read More

Adv Skin Wound Care 2019 Apr;32(4):183-189

In Seoul, South Korea, Yeseul Eom, MD, is a resident in the Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; and Kyong-Je Woo, MD, PhD, is an assistant professor, Department of Plastic Surgery, Mokdong Hospital, College of Medicine, Ewha Womans University. Acknowledgments: This work was supported by the Ewha Womans University Research Grant of 2017.

Objective: To evaluate the effectiveness of negative-pressure wound therapy (NPWT) for management of wound complications at extracorporeal membrane oxygenation (ECMO) removal sites.

Methods: The authors retrospectively reviewed patients who underwent NPWT at ECMO removal sites followed by the development of wound complications including skin necrosis, lymphorrhea, and femoral vessel exposure. A nonadhesive bacteria-binding mesh was used as a wound contact layer of NPWT application. Read More

Cornea 2019 Jun;38(6):775-779

Dr. Agarwal's Refractive and Cornea Foundation (DARCF), Chennai, India.

Purpose: To report a case with multiple macroperforations and a double anterior chamber (AC) after predescemetic deep anterior lamellar keratoplasty.

Methods: A patient was referred after undergoing complicated excision of pseudopterygium that extended onto the cornea. At presentation, an eccentric lamellar patch graft extending over the pupillary axis with a double AC was seen. Read More

Radiat Res 2019 04 13;191(4):360-368. Epub 2019 Feb 13.

Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.

Exposure to ionizing radiation combined with traumatic tissue injury is an important life-threatening condition found in the civilian populations after nuclear and radiological events. The significance feature of radiation combined injury (RCI) is the severe combined effect, which makes the injury more complicated. At present, there are limited measures available to treat RCI. Read More

Otol Neurotol 2019 03;40(3):e173-e177

Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia.

Objectives: Although many techniques have been proposed for the repair of tympanic membrane perforations, few address the unique challenges presented by anterior marginal perforations. In these circumstances, traditional underlay and overlay techniques are often complicated by issues including blunting of the anterior tympanomeatal angle, graft lateralization, delayed healing, and reduced graft take rates. The "window shade" tympanoplasty technique described in this paper incorporates several aspects of the underlay and overlay techniques to address these issues. Read More

Eur Arch Otorhinolaryngol 2019 Mar 2;276(3):673-677. Epub 2019 Jan 2.

Department of Otorhinolaryngology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, Basın Sitesi Mh. Karabağlar, Izmir, 35170, Turkey.

Objectives: To evaluate and compare functional outcomes of tympanoplasty procedures with temporalis fascia and four different types of cartilage grafts in chronic otitis media (COM) cases with normal preoperative hearing levels.

Methods: Records of patients who underwent type 1 tympanoplasty for non-complicated COM in a tertiary medical center between January 2010 and January 2017 were reviewed. Patients with central or marginal and dry perforations of the tympanic membrane, normal middle ear mucosa, intact ossicular chain and patients with a preoperative pure tone average (PTA) level of 25 dB or less and a word recognition score (WRS) of 88% or greater were included in the study. Read More

World Neurosurg 2019 Mar 24;123:323-327. Epub 2018 Dec 24.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, The National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.

Background: Isolated cervical pseudoaneurysms of the internal carotid artery (ICA) in patients with Marfan syndrome are extremely rare.

Case Description: A 73-year-old female with Marfan syndrome and history of multiple aortic aneurysms presented to an outside hospital with dysphagia, a mass in her neck, dizziness, nausea, and vomiting. A computed tomography angiogram showed bilateral cervical ICA pseudoaneurysms, more significant on the right side. Read More

Ann Plast Surg 2019 01;82(1):64-70

From the Department of Hand and Microsurgery, Xiangya Hospital, Central South University, Changsha, China.

Background: The closure of massive skin defects remains challenging, particularly in children. In this report, we describe a technique to achieve primary donor site closure using the kiss deep inferior epigastric perforator (DIEP) flap for the reconstruction of large soft tissue defects located in the extremities of children.

Methods: From May 2011 to May 2016, a retrospective analysis was conducted on 10 pediatric patients with extensive soft tissue defects and reconstruction with double-skin paddle DIEP flap. Read More

Cureus 2018 Sep 17;10(9):e3319. Epub 2018 Sep 17.

Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, USA.

Background: Hidradenitis suppurativa (HS) is a physically debilitating disease that greatly impairs the quality of life of affected individuals. Advanced disease is often difficult to treat with topical and systemic therapies. Surgical resection of diseased skin has become paramount in HS management but proposes challenges of wound care and closure. Read More

Eur Arch Otorhinolaryngol 2018 Dec 13;275(12):2975-2981. Epub 2018 Oct 13.

Department of Otorhinolaryngology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, 35170, Izmir, Turkey.

Objectives: To compare the anatomical and functional outcomes of two different grafts which are used for the reconstruction of subtotal or total tympanic membrane perforations: the wheel-shaped composite cartilage graft (WsCCG) and temporalis fascia (TF).

Methods: Ninety patients (94 ears) who underwent type 1 tympanoplasty for non-complicated chronic otitis media between March 2014 and June 2016 in a tertiary referral center were included in a randomized, controlled, prospective clinical trial. Tympanic membranes were reconstructed with the WsCCG or TF. Read More

World Neurosurg 2018 Dec 24;120:e497-e502. Epub 2018 Aug 24.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

Objective: To describe the incidence of and characterize risk factors for cerebrospinal fluid leak and symptomatic pseudomeningocele (CSFL/SP) after intradural spine surgery.

Methods: A retrospective analysis of a prospectively collected and consecutive series of patients undergoing intradural spine surgery by the senior author (A.D. Read More

Adv Drug Deliv Rev 2019 06 11;146:60-76. Epub 2018 Aug 11.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500HB Nijmegen, The Netherlands. Electronic address:

The healing of skeletal muscle injuries after major trauma or surgical reconstruction is often complicated by the development of fibrosis leading to impaired function. Research in the field of muscle regeneration is mainly focused on the restoration of muscle mass while far less attention is paid to the prevention of fibrosis. In this review, we take as an example the reconstruction of the muscles in the soft palate of cleft palate patients. Read More

J Robot Surg 2019 Apr 30;13(2):339-343. Epub 2018 Jul 30.

Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The case is of a 59-year-old male with history of severe ischemic colitis following emergent intervention for a ruptured infrarenal aortic aneurysm who subsequently underwent left hemicolectomy, partial proctectomy, and Hartmann colostomy. The patient later underwent reversal of the Hartmann colostomy with diverting ileostomy. The surgery was complicated by a right ureteral and posterior bladder injury that resulted in a large rectovesical fistula involving the right hemitrigone and right ureteral orifice. Read More

Otolaryngol Head Neck Surg 2018 11 10;159(5):879-886. Epub 2018 Jul 10.

1 Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla Province, Thailand.

Objective: Although overlay grafting for complicated tympanic perforations offers a high success rate, potential complications may outweigh its advantages. This study aimed to assess endoscopic overlay tympanoplasty (EOT), compared with microscopic overlay tympanoplasty (MOT), to optimize outcomes while minimizing complications associated with large tympanic perforations.

Study Design: Nonmasked, randomized. Read More

Adv Wound Care (New Rochelle) 2018 Jul;7(7):209-231

European Molecular Biology Laboratory Australia, Australian Regenerative Medicine Institute, Monash University, Victoria, Australia.

The immune system plays a central role in orchestrating the tissue healing process. Hence, controlling the immune system to promote tissue repair and regeneration is an attractive approach when designing regenerative strategies. This review discusses the pathophysiology of both acute and chronic wounds and possible strategies to control the immune system to accelerate chronic wound closure and promote skin regeneration (scar-less healing) of acute wounds. Read More

Am Surg 2018 Jun;84(6):938-946

Postoperative surgical site infections (SSIs) are one of the most common complications. SSIs after laparotomy have a high incidence and are complicated and expensive to heal. The aim of this study was to evaluate the safety and efficacy of a novel therapy of early closure of open abdominal SSIs wound combining wound irrigation with negative pressure wound therapy (NPWT). Read More

Cardiovasc Revasc Med 2018 12 15;19(8S):82-85. Epub 2018 Jun 15.

Department of Cardiology, Cardiac Catheterization Laboratories, Rabin Medical Center, Petah Tikva & The "Sackler" Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

A 75 year-old female with symptomatic severe mitral regurgitation of a bio-prosthetic valve secondary to valve leaflet perforation due to endocarditis underwent a mitral valve in valve replacement in an existing Hancock 27 mm valve using a trans-femoral/trans-septal approach. The procedure was complicated by an iatrogenic atrial septal defect post trans-septal puncture causing a severe right-to-left shunt due, possibly, to the combination of severe pulmonary hypertension and moderate tricuspid regurgitation the patient had suffered from at base line. Once the sheath was removed an immediate desaturation was observed which required emergent closure with an AMPLATZER ASD Occluder device (St. Read More

BMC Surg 2018 Jun 15;18(1):41. Epub 2018 Jun 15.

Department of Digestive and General Surgery, Shimane University Faculty of Medicine, 89-1, Enyacho, Izumo, Shimane, 693-8501, Japan.

Background: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound. Read More

Vet Comp Orthop Traumatol 2018 Jul 11;31(4):229-238. Epub 2018 Jun 11.

Department for Clinical Veterinary Medicine, Clinic for Small Animal Surgery and Reproduction, Ludwig-Maximilians University, Munich, Bayern, Germany.

Objectives:  To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.

Study Type:  Prospective randomized clinical study MATERIALS AND METHODS:  Dogs ( = 26) undergoing open-wound treatment were randomly assigned to one of two groups: Group A ( = 13) NPWT; Group B ( = 13) silver-coated foam dressing. Pairs of patients were matched based on wound conformation, localization, and underlying cause and compared in terms of duration of previous treatment, development of wound size (wound planimetry), time to closure, bacterial bio-burden and complications. Read More

Int Wound J 2018 Oct 5;15(5):749-755. Epub 2018 Jun 5.

Centre of Excellence in Biofilm Science and Technologies (CEBST), 5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, Liverpool, UK.

Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents, and dispersants in both the food and oil industry. Their use in a clinical setting is also common, particularly in wound care. Complicated or chronic wounds show clinical signs of delayed healing, persistent inflammation, and the production of non-viable tissue. Read More

Wounds 2018 Jan;30(1):E1-E4

General Surgery Department, Hospital de Braga, Braga, Portugal; and Surgical Sciences Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.

Introduction: Performing surgery on patients with Crohn's disease is a true challenge due to the elevated risk of complications related to the chronic proinflammatory response. Stenosis is the leading cause of intestinal resection in these patients.

Case Report: The authors present the case of a 50-year-old woman with inflammatory stenosis of the terminal ileum due to Crohn's disease. Read More

Medicine (Baltimore) 2017 Dec;96(52):e9370

Department of Dermatology.

Rationale: An open abdomen complicated with small-bowel fistulae becomes a complex wound for local infection, systemic sepsis and persistent soiling irritation by intestinal content. While controlling the fistulae drainage, protecting surrounding skin, healing the wound maybe a challenge.

Patient Concerns: In this paper we described a 68-year-old female was admitted to emergency surgery in general surgery department with severe abdomen pain. Read More

Expert Rev Med Devices 2018 02 18;15(2):145-155. Epub 2018 Jan 18.

c Chairman, Division of Orthopaedic Surgery , Albany Medical Center , Albany , NY, USA.

Introduction: Acute traumatic or surgical wounds that cannot be primarily closed often cause substantial morbidity and mortality. This often leads to increased costs from higher material expenses, more involved nursing care, and longer hospital stays. Advancements in soft tissue expansion has made it a popular alternative to facilitate early closure without the need for more complicated plastic surgical procedures. Read More

J Foot Ankle Surg 2018 May - Jun;57(3):456-461. Epub 2017 Dec 19.

Third-Year Resident, Foot and Ankle Surgery Residency Program, Regions Hospital/HealthPartners Institute for Education and Research, St. Paul, MN. Electronic address:

Distal hallux gangrene and neuropathic ulceration associated with digit deformity frequently result in osteomyelitis of the distal phalanx. Ideal treatment would involve limited resection to preserve function. We describe our surgical technique and retrospective results for distal Syme hallux amputation with plantar flap closure. Read More

Int Ophthalmol 2019 Jan 19;39(1):225-230. Epub 2017 Dec 19.

First Department of Ophthalmology, National and Kapodistrian University of Athens, 11527, Athens, Greece.

Purpose: To describe the use of equine pericardium as an off-label temporary emergency treatment of scleral and corneal perforations.

Methods: Three eyes of two male patients aged 34 and 38 years were included, i.e. Read More

J Wound Care 2017 12;26(12):712-719

Trauma and Orthopaedic Consultant, Broomfield Hospital, Chelmsford, UK.

Objective: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Read More