2,823 results match your criteria Clostridium Difficile Colitis


Total proctocolectomy with end ileostomy for acute onset of ulcerative colitis during chemoradiotherapy for lung adenocarcinoma (successfully treated by surgery): a case report.

Surg Case Rep 2020 Jun 1;6(1):121. Epub 2020 Jun 1.

Department of General Surgery, Toyohashi Municipal Hospital, 50 Hachiken-nishi, Aotake-cho, Toyohashi, Aichi, 441-8570, Japan.

Background: Ulcerative colitis (UC) developing during chemotherapy is very rare. Here, we describe a case of acute onset during chemoradiotherapy for lung adenocarcinoma, requiring a total proctocolectomy.

Case Presentation: A 52-year-old man was admitted to the hospital for chemoradiotherapy of lung cancer. Read More

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http://dx.doi.org/10.1186/s40792-020-00886-xDOI Listing

The Clinical Drug Ebselen Attenuates Inflammation and Promotes Microbiome Recovery in Mice after Antibiotic Treatment for CDI.

Cell Rep Med 2020 Apr;1(1)

Cancer Biology Program, Stanford School of Medicine, Stanford, CA 94305 USA.

infection (CDI) is an enteric bacterial disease that is increasing in prevalence worldwide. capitalizes on gut inflammation and microbiome dysbiosis to establish infection, with symptoms ranging from watery diarrhea to toxic megacolon. We reported that the safe-in-human clinical drug ebselen (ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.xcrm.2020.100005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263476PMC

Endovascular Intervention of a Mycotic Pseudoaneurysm of Accessory Left Hepatic Artery Arising from the Left Gastric Artery Presenting Secondary to Clostridium difficile Colitis: A Case Report.

Cureus 2020 Apr 23;12(4):e7802. Epub 2020 Apr 23.

Vascular Surgery, Beaumont Health, Farmington Hills, USA.

Hepatic artery aneurysms have an estimated incidence of approximately 0.002%, of which one half are pseudoaneurysms (PsAs). These typically occur following trauma or liver transplant and are often asymptomatic. Read More

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http://dx.doi.org/10.7759/cureus.7802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243847PMC

[Updated review of Clostridium difficile infection in elderly].

Rev Esp Geriatr Gerontol 2020 May 15. Epub 2020 May 15.

Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.

Clostridium difficile infection is the most common cause of health care-associated diarrhoea, and its incidence increases with age. Clinical challenges, risk of resistance to treatment, risk of recurrence, and treatment responses are different in elderly. The aim of this review is to discuss the updated epidemiology, pathophysiology, diagnosis, and therapeutic management of C. Read More

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http://dx.doi.org/10.1016/j.regg.2019.12.003DOI Listing

Characteristics of Fecal Microbiota Transplantation Use in Inflammatory Bowel Disease Cohort.

Crohns Colitis 360 2020 Apr 18;2(2):otaa024. Epub 2020 Apr 18.

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: There is a growing interest in the role of gut bacteria in a number of diseases and an emerging hypothesis that inflammatory bowel disease (IBD) is triggered by microbial dysbiosis in genetically susceptible individuals. Currently, fecal microbiota transplantation (FMT) is utilized for the treatment of lostridium colitis. Data on the efficacy of FMT for IBD are mixed, but patients are interested in its use for the treatment of IBD. Read More

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http://dx.doi.org/10.1093/crocol/otaa024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215656PMC

Clostridium Difficile Infection in Patients Impact Suspected Cytomegalovirus Infection in Patients with Inflammatory Bowel Disease.

Mater Sociomed 2020 Mar;32(1):41-45

Division of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Introduction: infection (CDI) has been reported to be a cause of flare-ups in patients with inflammatory bowel disease (IBD). Cytomegalovirus (CMV) infection can cause severe disease and complications in immunocompromised patients in consequence of disease or therapy.

Aim: Our aim was to describe the prevalence and clinical outcomes of CDI with concomitant CMV infection in IBD patients hospitalized for flare-ups in association with the disease itself and medication used. Read More

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http://dx.doi.org/10.5455/msm.2020.32.41-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219720PMC

Antimicrobial susceptibilities of isolated in 12 Asia-Pacific countries, 2014-15.

Antimicrob Agents Chemother 2020 May 11. Epub 2020 May 11.

School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

causes toxin-mediated diarrhoea and pseudomembranous colitis, primarily among hospital inpatients. Outbreaks of infection (CDI) have been caused by strains with acquired antimicrobial resistance, particularly fluoroquinolone resistance, including ribotype (RT) 027 in North America and Europe, and RT 017, the most common strain in Asia. Despite being the most common cause of hospital-acquired infection in high-income countries, and frequent misuse of antimicrobials in Asia, little is known about CDI in the Asia-Pacific region. Read More

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http://dx.doi.org/10.1128/AAC.00296-20DOI Listing

Systemic Inflammatory Mediators Are Effective Biomarkers for Predicting Adverse Outcomes in Clostridioides difficile Infection.

mBio 2020 May 5;11(3). Epub 2020 May 5.

Infectious Diseases Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

infection (CDI) can result in severe disease and death, with no accurate models that allow for early prediction of adverse outcomes. To address this need, we sought to develop serum-based biomarker models to predict CDI outcomes. We prospectively collected sera ≤48 h after diagnosis of CDI in two cohorts. Read More

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http://dx.doi.org/10.1128/mBio.00180-20DOI Listing

Evaluation of glutamate dehydrogenase (GDH) and toxin A/B rapid tests for Clostridioides (prev. Clostridium) difficile diagnosis in a university hospital in Minas Gerais, Brazil.

Braz J Microbiol 2020 May 4. Epub 2020 May 4.

Veterinary School, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Belo Horizonte, MG, 31.270-901, Brazil.

Clostridioides (Clostridium) difficile is responsible for most cases of nosocomial diarrhea and, despite the high prevalence of the disease worldwide, the best laboratory diagnostic approach to diagnose C. difficile infection (CDI) is a subject of ongoing debate. Although the use of multiple tests is recommended, the cost of these algorithms commonly exceeds the affordability in some countries. Read More

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http://dx.doi.org/10.1007/s42770-020-00288-zDOI Listing

Syntheses and structure-activity relationships in antibacterial activity against Clostridium difficile and XBP1 activation property of 13-(N-alkyl)-aminomethyl-8-oxodihydrocoptisines.

Chem Biodivers 2020 May 4. Epub 2020 May 4.

Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Materia Medica, Pharmacology, A No. 2, Nan Wei Road, Beijing, CHINA.

13-( N -alkyl)-aminomethyl-8-oxo-dihydrocotisines were synthesized to evaluate antibacterial activity against Clostridium difficile and activating x-box-binding protein 1 activity, biological properties both associated with ulcerative colitis. Improving structural stability and ameliorating biological activity were major concerns. Different substituents on the structural modification site were involved to explore the influence of diverse structures on the bioactivities. Read More

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http://dx.doi.org/10.1002/cbdv.202000265DOI Listing

Immunochromatographic test and ELISA for the detection of glutamate dehydrogenase (GDH) and A/B toxins as an alternative for the diagnosis of Clostridioides (Clostridium) difficile-associated diarrhea in foals and neonatal piglets.

Braz J Microbiol 2020 May 3. Epub 2020 May 3.

Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, Belo Horizonte, MG, Brazil.

Considering the lack of studies evaluating the performance of commercially available methods for diagnosis of Clostridioides (Clostridium) difficile infection (CDI) in animals, the present study aimed to assess an immunochromatographic test for detection of glutamate dehydrogenase (GDH) and A/B toxins of C. difficile, also evaluated by an ELISA kit, in foals and neonatal piglets. Intestinal contents of 47 piglets and feces of 35 foals were tested to GDH antigen and A/B toxins in a lateral flow method (Ecodiagnostica, Brazil). Read More

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http://dx.doi.org/10.1007/s42770-020-00275-4DOI Listing

Evaluation of anti-infective-related -associated colitis using the Japanese Adverse Drug Event Report database.

Int J Med Sci 2020 26;17(7):921-930. Epub 2020 Mar 26.

Laboratory of Drug Informatics, Gifu Pharmaceutical University; Gifu, Japan.

-associated colitis (CDAC) may cause gastrointestinal illness, ranging in severity from mild diarrhea to fulminant colitis and even mortality. The purpose of this study was to evaluate anti-infective-related CDAC profiles using the Japanese Adverse Drug Event Report (JADER) database. : We selected case reports of adverse events of CDAC as specified in the Medical Dictionary for Regulatory Activities. Read More

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http://dx.doi.org/10.7150/ijms.43789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163355PMC

Incidental benefits after fecal microbiota transplant for ulcerative colitis.

Intest Res 2020 Apr 22. Epub 2020 Apr 22.

Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.

Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders and other conditions like metabolic syndrome and functional gastrointestinal disorders. Amongst various therapies targeting gut microbiome, fecal microbiota transplantation (FMT) is becoming a focus in the public media and peer reviewed literature. We have been using FMT for induction of remission in patients with moderate to severe active ulcerative colitis (UC) and also for subsequent maintenance of remission. Read More

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http://dx.doi.org/10.5217/ir.2019.00108DOI Listing

Clostridium Difficile Infection Complicating Acute Severe Colitis During Pregnancy.

Inflamm Bowel Dis 2020 May;26(6):e53

Department of Gastroenterology, Flinders Medical Centre, South Australia, Australia.

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http://dx.doi.org/10.1093/ibd/izaa067DOI Listing

Opportunistic bowel infection after corticosteroid dosage tapering in a stage IV lung cancer patient with tislelizumab-related colitis.

Thorac Cancer 2020 Jun 2;11(6):1699-1702. Epub 2020 Apr 2.

Department of Pulmonary and Critical Care Medicine, Peking Union Medical Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Immune checkpoint inhibitors, the new standard in cancer therapy, present durable responses in numerous solid tumors and hematologic malignancies, as well as resulting in an increased incidence of immune-related adverse events (irAEs). Diarrhea is a common irAE, with an incidence rate of approximately 10% to 13%. It is important to distinguish between diarrhea symptomatic of an infection, which is the main differential diagnosis, and immune-related diarrhea. Read More

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http://dx.doi.org/10.1111/1759-7714.13401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262879PMC

[Interactions between intestinal microbiota and Clostridioides difficile].

Rev Prat 2019 Sep;69(7):784-791

Unité d'hygiène et de lutte contre les infections nosocomiales, hôpital Saint-Antoine, Paris, France. Laboratoire Clostridium difficile associé au CNR des bactéries anaérobies, hôpital Saint-Antoine, Paris, France. Inserm S-1139, faculté de pharmacie de Paris, université de Paris, Paris, France.

Interactions between intestinal microbiota and clostridioides difficile. Clostridioides difficile is a spore-forming anaerobic Gram-positive bacillus that is responsible for diarrhea and post-antibiotic colitis. Approximately 20,000 inpatients are infected by C. Read More

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September 2019

Guidelines for infection in adults.

Prz Gastroenterol 2020 19;15(1):1-21. Epub 2020 Mar 19.

Central Clinical Hospital of Ministry of Inferior and Administration, Warsaw, Poland.

infection (CDI) has become a serious medical and epidemiological problem, especially in well developed countries. There has been evident increase in incidence and severity of CDI. Prevention, proper diagnosis and effective treatment are necessary to reduce the risk for the patients, deplete the spreading of infection and diminish the probability of recurrent infection. Read More

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http://dx.doi.org/10.5114/pg.2020.93629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089862PMC

Diagnostic Modality of Clostridioides difficile Infection Predicts Treatment Response and Outcomes in Inflammatory Bowel Disease.

Dig Dis Sci 2020 Mar 23. Epub 2020 Mar 23.

IBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, Roanoke, VA, 24016, USA.

Background: Inflammatory bowel disease (IBD) patients are at increased risk of developing Clostridioides difficile infection (CDI). Common methods to diagnose CDI involve a combination of tests including the toxin A/B enzyme immunoassay (Toxin) and toxin gene polymerase chain reaction assay (PCR). Disease outcomes in Toxin+ versus Toxin-PCR+ IBD patients remain unclear. Read More

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http://dx.doi.org/10.1007/s10620-020-06205-6DOI Listing

Development and Characterization of Mouse Monoclonal Antibodies Specific for Lipoteichoic Acid.

ACS Chem Biol 2020 04 1;15(4):1050-1058. Epub 2020 Apr 1.

Vaccine and Emerging Infections Research, Human Health Therapeutics Research Centre, National Research Council, Ottawa, Ontario K1A 0R6, Canada.

is an anaerobic Gram-positive, spore-forming nosocomial, gastrointestinal pathogen causing -associated disease with symptoms ranging from mild cases of antibiotic-associated diarrhea to fatal pseudomembranous colitis. We developed murine monoclonal antibodies (mAbs) specific for a conserved cell surface antigen, lipoteichoic acid (LTA)of . The mAbs were characterized in terms of their thermal stability, solubility, and their binding to LTA by surface plasmon resonance and competitive ELISA. Read More

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http://dx.doi.org/10.1021/acschembio.0c00066DOI Listing

Assessing the efficacy and safety of fecal microbiota transplantation and probiotic VSL#3 for active ulcerative colitis: A systematic review and meta-analysis.

PLoS One 2020 17;15(3):e0228846. Epub 2020 Mar 17.

Department of Clinical Microbiology, Medical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: Fecal microbiota transplantation is an effective treatment for many gastrointestinal diseases, such as Clostridium difficile infection and inflammatory bowel disease, especially ulcerative colitis. Changes in colonic microflora may play an important role in the pathogenesis of ulcerative colitis, and improvements in the intestinal microflora may relieve the disease. Fecal bacterial transplants and oral probiotics are becoming important ways to relieve active ulcerative colitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077802PMC

Clostridium difficile infection after ileostomy reversal: A Case Report.

Ann Coloproctol 2020 Mar 16. Epub 2020 Mar 16.

Division of Colorectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Clostridium difficile infection (CDI) after ileostomy reversal is rare, and few reports in the available literature describe this condition. Diagnosis of CDI after ileostomy reversal is challenging because symptoms such as diarrhea observed in these patients can occur frequently after surgery. However, CDI can be fatal, and early diagnosis and prompt treatment are important. Read More

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http://dx.doi.org/10.3393/ac.2019.09.24DOI Listing

Unusual Presentation of Methicillin-Resistant Colitis Complicated with Acute Appendicitis.

J Glob Infect Dis 2020 Jan-Mar;12(1):34-36. Epub 2020 Feb 19.

Division of Pulmonary and Critical Care, St. Joseph's University Medical Center, Paterson, NJ, USA.

Clostridium difficile colitis has been the most recognized bacterial enterocolitis for years and other bacteria such as Staphylococcus colitis has been relegated. Staphylococcus enterocolitis following antibiotics had been one of the most frequent complications in surgical patients in the 1950s and 1960s and now reappear with more resistance such as methicillin-resistant(MRSA) colitis which brings a new challenge. A 32-year-old Hispanic female with a history of type I diabetes mellitus presenting with altered sensorium and a 2-day history of watery, nonbloody diarrhea, intractable emesis, and diffuse crampy abdominal pain. Read More

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http://dx.doi.org/10.4103/jgid.jgid_117_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045764PMC
February 2020

ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity.

mSphere 2020 Mar 11;5(2). Epub 2020 Mar 11.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

is a spore-forming bacterium that causes severe colitis and is a major public health threat. During infection, toxin production results in damage to the epithelium and a hyperinflammatory response. The immune response to CDI leads to robust neutrophil infiltration at the sight of infection and the deployment of numerous antimicrobials. Read More

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http://dx.doi.org/10.1128/mSphere.00061-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067591PMC

Isolation of Clostridium perfringens and Clostridioides difficile in diarrheic and nondiarrheic cats.

Anaerobe 2020 Apr 21;62:102164. Epub 2020 Jan 21.

Veterinary School, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos, 6627, Belo Horizonte, MG, CEP 31.270-901, Brazil.

The occurrence and characteristics of Clostridioides (previously Clostridium) difficile and Clostridium perfringens in the feces of diarrheic and non-diarrheic cats was investigated. Apparently healthy animals were more likely to be positive for C. perfringens type A (p = 0. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102164DOI Listing

Comparison of Disease Phenotypes and Clinical Characteristics Among South Asian and White Patients with Inflammatory Bowel Disease at a Tertiary Referral Center.

Inflamm Bowel Dis 2020 Mar 7. Epub 2020 Mar 7.

Department of Internal Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

Background: The prevalence and clinical features of inflammatory bowel disease (IBD) vary among different racial and ethnic groups. The aim of this study was to compare the clinical and phenotypic features of Crohn's disease (CD) and ulcerative colitis (UC) in South Asian patients living in the United States with those of a white cohort.

Methods: The demographic, clinical, and phenotypic characteristics of 73 South Asian patients (31 CD and 42 UC) who presented initially to our tertiary referral center from 2012 to 2016 and had subsequent follow-up were retrospectively compared with those of 408 consecutive white patients (245 CD and 163 UC). Read More

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http://dx.doi.org/10.1093/ibd/izaa019DOI Listing

Microbiota insights in infection and inflammatory bowel disease.

Gut Microbes 2020 Mar 4:1-25. Epub 2020 Mar 4.

Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.

Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation that includes Crohn´s disease (CD) and ulcerative colitis (UC). Although the etiology is still unknown, some specific factors have been directly related to IBD, including genetic factors, abnormal intestinal immunity, and/or gut microbiota modifications. Recent findings highlight the primary role of the gut microbiota closely associated with a persistent inappropriate inflammatory response. Read More

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http://dx.doi.org/10.1080/19490976.2020.1725220DOI Listing

Fecal Microbiota Transplantation: Redefining Surgical Management of Refractory Infection.

Clin Colon Rectal Surg 2020 Mar 25;33(2):92-97. Epub 2020 Feb 25.

Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Fecal microbiota transplantation (FMT) is the process of transplanting stool from a healthy donor into the gut of a diseased individual for therapeutic purposes. It has a clearly defined role in the treatment of recurrent (reclassified as " ") infection (CDI), with cure rates over 90% and decreased rates of subsequent recurrence compared with anti-CDI antibiotics. There is emerging evidence that FMT is also effective in the treatment of severe and fulminant CDI, with associated decreases in mortality and colectomy rates compared with standard antibiotic therapy. Read More

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http://dx.doi.org/10.1055/s-0040-1701233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042019PMC

Physical, Laboratory, Radiographic, and Endoscopic Workup for Colitis.

Clin Colon Rectal Surg 2020 Mar 25;33(2):82-86. Epub 2020 Feb 25.

Department of Gastrointestinal Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

(reclassified as " ") colitis is a common nosocomial infection associated with increased morbidity and mortality. Like many clinical encounters, a focused history and physical examination will help to guide initial management. Further laboratory testing will assist with diagnosis through stool studies, and blood tests, such as white blood cell counts and serum creatinine, can help to stratify patients into illness severity groups for treatment decisions. Read More

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http://dx.doi.org/10.1055/s-0039-3400474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042018PMC

Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant K Infection in a Critically Ill Patient.

Case Rep Infect Dis 2020 12;2020:8462659. Epub 2020 Feb 12.

Genetics Department, Ampath National Reference Laboratory, Centurion, South Africa.

Dysbiosis of the microbiome is a common finding in critically ill patients, who receive broad-spectrum antibiotics and various forms of organ support. Multidrug-resistant (MDR) organisms are a growing threat in all areas of medicine, but most markedly in the critically ill, where there is both loss of host defences and widespread use of broad spectrum antibiotics. We present a case of a critically ill patient with persistent MDR infection, successfully treated with fecal microbiota transplantation (FMT), using stool of a rigorously-screened, healthy donor. Read More

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http://dx.doi.org/10.1155/2020/8462659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038171PMC
February 2020

Fecal transplantation for ulcerative colitis: current evidence and future applications.

Expert Opin Biol Ther 2020 Apr 26;20(4):343-351. Epub 2020 Feb 26.

UOC MEDICINA INTERNA E GASTROENTEROLOGIA, Area Medicina Interna, Gastroenterologia ed Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

: Established evidence suggests that gut microbiota plays a role in ulcerative colitis (UC). Fecal microbiota transplantation (FMT) is clearly recognized as a highly effective treatment for patients with recurrent Clostridium difficile infection and has been investigated also in patients with UC, with promising results.: Literature review was performed to select publications concerning current evidence on the role of gut microbiota in the pathogenesis of UC, and on the effectiveness of FMT in this disorder. Read More

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http://dx.doi.org/10.1080/14712598.2020.1733964DOI Listing

Clinical impact of a pharmacist-led antimicrobial stewardship initiative evaluating patients with colitis.

J Investig Med 2020 Apr 16;68(4):888-892. Epub 2020 Feb 16.

Department of Pharmacy, University of Florida Health at Jacksonville, Jacksonville, Florida, USA

is the most common cause of healthcare-associated infection and gastroenteritis-associated death in the USA. Adherence to guideline recommendations for treatment of severe infection (CDI) is associated with improved clinical success and reduced mortality. The purpose of this study was to determine whether implementation of a pharmacist-led antimicrobial stewardship program (ASP) CDI initiative improved adherence to CDI treatment guidelines and clinical outcomes. Read More

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http://dx.doi.org/10.1136/jim-2019-001173DOI Listing

Patient Experiences with Infection: Results of a Canada-Wide Survey.

Patient Prefer Adherence 2020 6;14:33-43. Epub 2020 Jan 6.

Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Purpose: infection (CDI) is the most prevalent cause of nosocomial infectious diarrhea in Canada and is highly correlated with antibiotic use and contact with health care facilitates. The often-severe symptoms of CDI include diarrhea, dehydration, and abdominal pain. Patients often relapse following symptom resolution, resulting in increased morbidity. Read More

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http://dx.doi.org/10.2147/PPA.S229539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954101PMC
January 2020

Hidradenitis suppurativa and risk for development of Clostridium difficile colitis.

Int J Dermatol 2020 Jun 3;59(6):e218-e219. Epub 2020 Feb 3.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

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http://dx.doi.org/10.1111/ijd.14787DOI Listing

Comparative of the Effectiveness and Safety of Biological Agents, Tofacitinib, and Fecal Microbiota Transplantation in Ulcerative Colitis: Systematic Review and Network Meta-Analysis.

Immunol Invest 2020 Feb 2:1-15. Epub 2020 Feb 2.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Background: Biological agents are commonly used for the treatment of ulcerative colitis (UC). As new treatments, tofacitinib, and fecal microbiota transplantation (FMT) have demonstrated efficacy in treating UC. This network meta-analysis aims to determine the efficacy and safety of biological agents, tofacitinib, and FMT. Read More

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http://dx.doi.org/10.1080/08820139.2020.1714650DOI Listing
February 2020

Abnormal Intestinal Microbiome in Medical Disorders and Potential Reversibility by Fecal Microbiota Transplantation.

Dig Dis Sci 2020 Mar;65(3):741-756

Kelsey Research Foundation, Houston, TX, USA.

Reduction in diversity of the intestinal microbiome (dysbiosis) is being identified in many disease states, and studies are showing important biologic contributions of microbiome to health and disease. Fecal microbiota transplantation (FMT) is being evaluated as a way to reverse dysbiosis in diseases and disorders in an attempt to improve health. The published literature was reviewed to determine the value of FMT in the treatment of medical disorders for which clinical trials have recently been conducted. Read More

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http://dx.doi.org/10.1007/s10620-020-06102-yDOI Listing

Clostridioides difficile Infection: Update on Management.

Am Fam Physician 2020 02;101(3):168-175

Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

Guidelines for the diagnosis and treatment of Clostridioides difficile infection have recently been updated. Risk factors include recent exposure to health care facilities or antibiotics, especially clindamycin. C. Read More

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February 2020

Fecal microbiota transplantation in children does not significantly alter body mass index.

Transl Pediatr 2019 Dec;8(5):398-401

Division of Gastroenterology, Hepatology and Nutrition, Miller Children's Hospital and the University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

Background: Fecal microbiota transplantation (FMT) is nowadays a promising therapy for Clostridium difficile infection (CDI) and a potential treatment for ulcerative colitis. However, it is still unclear whether the changes in intestinal microbiome will affect energy homeostasis or metabolism. This brings an intriguing question whether FMT from healthy donors affects recipient's body mass index (BMI). Read More

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http://dx.doi.org/10.21037/tp.2019.09.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970120PMC
December 2019

IL-17-producing γδ T cells protect against Clostridium difficile infection.

J Clin Invest 2020 May;130(5):2377-2390

Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and mortality, especially after antibiotic use in health care settings. The natural immunity of newborn infants and protective host immune mediators against C. difficile infection are not fully understood, with data suggesting that inflammation can be either protective or pathogenic. Read More

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http://dx.doi.org/10.1172/JCI127242DOI Listing

Editorial to Temporal Gut Microbial Changes Predict Recurrent Clostridium difficile Infection in Patients With and Without Ulcerative Colitis.

Inflamm Bowel Dis 2020 Jan 22. Epub 2020 Jan 22.

Division of Gastroenterology, Hepatology and Nutriton, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1093/ibd/izz336DOI Listing
January 2020

Fecal microbiota transplantation in ulcerative colitis.

Acta Gastroenterol Belg 2019 Oct-Dec;82(4):519-528

Department of Gastroenterology, AZ Sint-Lucas, Ghent, Belgium.

Background/study Aims: Fecal microbiota transplantation (FMT), a treatment aiming to restore dysbiosis by transferring stool from a healthy donor into the patient, has cure rates up to 90% in the management of recurrent Clostridium difficile (C. difficile) diarrhea. This paper tries to determine whether FMT is safe and effective in the treatment of ulcerative colitis, and what the potential characteristics could be of a 'super donor'. Read More

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February 2020

Activity of Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis Predicts Poorer Clinical Outcomes.

Inflamm Bowel Dis 2020 Jan 16. Epub 2020 Jan 16.

Liver Transplant Unit, Heidelberg, Victoria, Australia.

Background: The impact of inflammatory bowel disease (IBD) activity on long-term outcomes after liver transplantation (LT) for primary sclerosing cholangitis (PSC) is unknown. We examined the impact of post-LT IBD activity on clinically significant outcomes.

Methods: One hundred twelve patients undergoing LT for PSC from 2 centers were studied for a median of 7 years. Read More

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http://dx.doi.org/10.1093/ibd/izz325DOI Listing
January 2020

A Complex Scenario of Nonsteroidal Anti-inflammatory Drugs Induced Prostaglandin E2 Production and Gut Microbiota Alteration in Clostridium difficile-Infected Mice.

mBio 2020 01 14;11(1). Epub 2020 Jan 14.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1128/mBio.02596-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960283PMC
January 2020

Acute appendicitis in a patient after a uterus transplant: A case report.

World J Clin Cases 2019 12;7(24):4270-4276

Department of Transplant Surgery, Institute for Clinical and Experimental Medicine, Prague 140 21, Czech Republic

Background: Acute appendicitis in a solid organ transplant recipient is a rare occurrence, and experience remains limited. Appendicitis in uterine transplant recipients has never been reported. Immunocompromised patients with acute abdomen often present late and with attenuated symptoms. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i24.4270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940341PMC
December 2019

The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.

FASEB J 2020 Feb 17;34(2):2198-2212. Epub 2019 Dec 17.

Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.

Clostridioides difficile (formerly Clostridium difficile; C difficile), the leading cause of nosocomial antibiotic-associated colitis and diarrhea in the industrialized world, triggers colonic disease through the release two toxins, toxin A (TcdA) and toxin B (TcdB), glucosyltransferases that modulate monomeric G-protein function and alter cytoskeletal function. The initial degree of the host immune response to C difficile and its pathogenic toxins is a common indicator of disease severity and infection recurrence. Thus, targeting the intestinal inflammatory response during infection could significantly decrease disease morbidity and mortality. Read More

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http://dx.doi.org/10.1096/fj.201902083RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027580PMC
February 2020

The level of fecal calprotectin significantly correlates with Clostridium difficile infection severity.

Folia Med Cracov 2019 ;59(3):53-65

Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Fecal calprotectin (FC) rises significantly in intestinal inflammation accompanied by neutrophil activation - such as Clostridium difficile infection (CDI). The aim of the study was to evaluate the benefit of FC testing in assessing the severity of CDI.

Materials And Methods: The study group included 76 patients with CDI hospitalized in the Jagiellonian University Hospital in Krakow from July 2017 till January 2018. Read More

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Preventive Effects of against Dextran Sulfate Sodium- and -Induced Inflammatory Bowel Disease in Mice.

Int J Mol Sci 2019 Dec 16;20(24). Epub 2019 Dec 16.

Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, 814 Siksa-dong, Ilsandong-gu, Goyang-si 10326, Korea.

Several lines of evidence indicate that inflammatory bowel disease (IBD) is associated with (CD) infection as a consequence of gut dysbiosis. Currently available treatments of IBD are either not very effective or have adverse effects. (PWS), a traditional Chinese herbal formulation, has long been used to treat gastrointestinal disorders. Read More

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http://dx.doi.org/10.3390/ijms20246346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940993PMC
December 2019

Effect of Sorbus domestica and its active constituents in an experimental model of colitis rats induced by acetic acid.

J Ethnopharmacol 2020 Apr 25;251:112521. Epub 2019 Dec 25.

Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.

Ethnopharmacological Relevance: In Turkish folk medicine, leaves of Sorbus domestica are used for the treatment of burns, cough, stomachache, bradyuria, kidney stone. The fruits of this plant are used for diarrhoea.

Aim Of The Study: This study was carried out to investigate the effect of S. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112521DOI Listing

Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.

J Exp Med 2020 Mar;217(3)

Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.

Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections (CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous colitis. Here, we examined the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI. We found that administration of acetate is remarkably beneficial in ameliorating disease. Read More

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http://dx.doi.org/10.1084/jem.20190489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062529PMC

infection in the Asia-Pacific region.

Emerg Microbes Infect 2020 24;9(1):42-52. Epub 2019 Dec 24.

Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.

causes healthcare-related diarrhoea in high-income countries. Highly resistant spores persist in healthcare facilities, primarily infecting patients who have recently received antimicrobials. infection (CDI) has been studied in detail in North America and Europe; however, the epidemiology of CDI elsewhere, including the Asia-Pacific region, is largely unknown. Read More

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http://dx.doi.org/10.1080/22221751.2019.1702480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968625PMC

Nonsteroidal Anti-Inflammatory Drugs Impact on the Outcomes of Hospitalized Patients with Infection.

Clin Exp Gastroenterol 2019 10;12:449-456. Epub 2019 Dec 10.

Department of Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

Purpose: Mouse model experiments have demonstrated an increased infection (CDI) severity with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) use. We aim to evaluate the impact of NSAIDs in humans after a diagnosis of CDI on primary outcomes defined as I) all-cause mortality and II) toxic mega-colon attributable to CDI.

Patients And Methods: All hospitalized patients with a diagnosis of CDI were divided into two groups; those with NSAIDs administered up to 10 days after onset of CDI versus no NSAIDs use. Read More

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http://dx.doi.org/10.2147/CEG.S223886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911331PMC
December 2019