1,367 results match your criteria Clostridial Gas Gangrene

Clostridial panophthalmitis - An unusual case of localised malignant oedema in Merino lambs associated with Clostridium chauvoei.

Aust Vet J 2022 Jun 6. Epub 2022 Jun 6.

Young Rural Lands Protection Board, Young, New South Wales, Australia.

The authors report an unusual case of Clostridium chauvoei causing severe panophthalmitis in Merino lambs. More than half of the lambs affected survived, which is unusual for clostridial disease; however, there have been reports in humans that the mortality risk for ocular gas gangrene is lower than when other body parts are affected. A combination of factors in this case included environmental contamination (specific to a particular paddock), genetics predisposing to entropion (lambs born of maiden 2-year-old ewes with some inbreeding), the practice of manually everting eyelids for the entropion and vaccination strategies. Read More

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Conservation and Evolution of the Sporulation Gene Set in Diverse Members of the .

J Bacteriol 2022 Jun 31;204(6):e0007922. Epub 2022 May 31.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Healthgrid.94365.3d, Bethesda, Maryland, USA.

The current classification of the phylum (new name, ) features eight distinct classes, six of which include known spore-forming bacteria. In Bacillus subtilis, sporulation involves up to 500 genes, many of which do not have orthologs in other bacilli and/or clostridia. Previous studies identified about 60 sporulation genes of B. Read More

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α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins.

Sci Immunol 2022 05 20;7(71):eabm1803. Epub 2022 May 20.

Division of Immunity, Inflammation and Infection, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

species are a group of Gram-positive bacteria that cause diseases in humans, such as food poisoning, botulism, and tetanus. Here, we analyzed 10 different species and identified that , a pathogen that causes sepsis and gas gangrene, activates the mammalian cytosolic inflammasome complex in mice and humans. Mechanistically, we demonstrate that α-toxin secreted by binds to glycosylphosphatidylinositol (GPI)-anchored proteins on the host plasma membrane, oligomerizing and forming a membrane pore that is permissive to efflux of magnesium and potassium ions. Read More

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Clostridium septicum foot gangrene associated with colorectal cancer.


Neuro Endocrinol Lett 2022 Apr 1;43(1). Epub 2022 Apr 1.

Introduction: Since the second half of the 20th century, an association between the occurrence of Clostridium septicum and Streptococcus gallolyticus infections in patients with colorectal cancer has been described in specialist literature. Infections are manifested by bacteremia, septic embolism, cellulitis, myonecrosis, and gas gangrene of the limbs.

Material And Methods: The authors present a case of a rare association between lower limb gangrene caused by the septic embolization of a Clostridium septicum infection and malignancy of colon ascendens in a polymorbid patient. Read More

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[Fatal necrotizing fasciitis with clostridium perfringens infection following resection of soft tissue sarcoma of the thigh].

Handchir Mikrochir Plast Chir 2022 Apr 13;54(2):155-159. Epub 2022 Apr 13.

BG-Universitätsklinikum Bergmannsheil Bochum; Klinik für Plastische Chirurgie und Handchirurgie, Schwerbrandverletztenzentrum.

We present the case of a 57-year-old male patient with a fatal outcome after resection of a soft tissue sarcoma of the lateral thigh. A polymicrobial surgical site infection with Staphylococcus lugdunensis and Clostridium perfringens caused fulminant necrotising fasciitis with an additional gas gangrene. The patient suffered a severe sepsis with consecutive haemolysis and multiorgan failure. Read More

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Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis.

Front Surg 2022 18;9:822605. Epub 2022 Mar 18.

Department of Gastrointestinal Surgery, The Second Hospital of Jilin University, Changchun, China.

Clostridial gas gangrene is an unusual but fast-spreading necrotic infection of soft tissue relevant to high mortality rates. We report a case of postoperative gas gangrene of the pelvic wall, scrotum, and perineal site, with very acute onset and rapid progression of symptoms after laparoscopic radical resection for rectal cancer. Although potentially treatable with appropriate antibiotic cover and urgent thorough surgical debridement, this case still developed irreversibly into fulminant and fatal sepsis. Read More

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Wound Infection with Multi-Drug Resistant : A Case Study.

Arch Razi Inst 2021 11 30;76(5):1565-1573. Epub 2021 Nov 30.

Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India.

Wound infections are among public health problems worldwide. However, progress has been made in improving surgical techniques and antibiotic treatments. Misuse/overuse of antibiotics to prevent and treat bacterial infections eventually leads to increased bacterial resistance with rising incidences of multi-drug resistant (MDR) bacterial strains. Read More

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November 2021

Necrotizing Fasciitis: A Life-Threatening Infection Due to Clostridium Species.

Cureus 2022 Feb 17;14(2):e22315. Epub 2022 Feb 17.

Internal Medicine, Hackensack Meridian Ocean Medical Center, Brick, USA.

Necrotizing fasciitis (NF), soft tissue infections, are rare but rapidly progressive and life-threatening infections with high morbidity and mortality rates. Early detection and intervention by physicians are paramount in mortality prevention. We present a case report of a 77-year-old female who presented with extensive NF due to a Clostridium septicum infection. Read More

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February 2022

Clostridium septicum myonecrosis following chemotherapy.

Int J Hematol 2022 05 11;115(5):609-610. Epub 2022 Mar 11.

Department of Haematology, Liverpool Hospital, Campbell St, Liverpool, NSW, 2170, Australia.

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Clostridial Diseases of Horses: A Review.

Vaccines (Basel) 2022 Feb 17;10(2). Epub 2022 Feb 17.

California Animal Health and Food Safety Laboratory, San Bernardino Lab, University of California-Davis, San Bwernardino, CA 92408, USA.

The clostridial diseases of horses can be divided into three major groups: enteric/enterotoxic, histotoxic, and neurotoxic. The main enteric/enterotoxic diseases include those produced by type C and , both of which are characterized by enterocolitis. The main histotoxic diseases are gas gangrene, Tyzzer disease, and infectious necrotic hepatitis. Read More

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February 2022

Fatal non-traumatic gas gangrene caused by type A in a Siberian Husky dog.

J Vet Diagn Invest 2022 May 18;34(3):518-522. Epub 2022 Feb 18.

School of Veterinary Science, University of Queensland, Gatton, QLD, Australia (Sprohnle-Barrera, Gibson, Price, Allavena).

An 8-y-old, castrated male Siberian Husky dog was admitted to an emergency clinic with acute collapse and severe swelling of both forelimbs, ventral thorax, and axillary region. The clinical assessment, with laboratory tests and radiologic investigation, confirmed severe subcutaneous emphysema and multi-organ failure. The animal died while receiving emergency treatment. Read More

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Gas gangrene, not a common infection: case report of post-traumatic fulminant death.

Clin Ter 2022 Feb;173(1):1-5

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Abstract: Post-traumatic gas gangrene is a rare but potentially life-threa-tening condition due to soft tissues infection by Clostridium species. These anaerobic microaerophile bacteria are highly resistant to external insults related to their ability to produce spores, which can survive on any surface for long periods. Under certain conditions suitable for proliferation (such as in ischemic tissues), bacteria produce many to-xins. Read More

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February 2022

Histopathological features of gas gangrene.

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):211-212

Department of Pathology, University College of Medical Sciences, Dilshad Garden, New Delhi, India.

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February 2022

Immunogenic and neutralization efficacy of recombinant perfringolysin O of Clostridium perfringens and its C-terminal receptor-binding domain in a murine model.

Immunol Res 2022 04 15;70(2):240-255. Epub 2022 Jan 15.

Gene Regulation Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.

Clostridium perfringens is a Gram-positive anaerobe ubiquitously present in different environments, including the gut of humans and animals. C. perfringens have been classified in the seven toxinotypes based on the secreted toxins that cause different diseases in humans and animals. Read More

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First Comparative Analysis of Genomes Provides Insights Into the Taxonomy, Species Genetic Diversity, and Virulence Related to Gas Gangrene.

Front Microbiol 2021 9;12:771945. Epub 2021 Dec 9.

Institute of Bacterial Infections and Zoonoses, Friedrich-Loeffler-Institut, Jena, Germany.

is a Gram-positive, toxin-producing, and spore-forming bacterium that is recognized, together with , as the most important etiologic agent of progressive gas gangrene. infections are almost always fatal in humans and animals. Despite its clinical and agricultural relevance, there is currently limited knowledge of the diversity and genome structure of . Read More

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December 2021

Fatal Clostridium perfringens sepsis with spleen rupture and intraabdominal massive bleeding in a 37-week pregnancy.

IDCases 2021 29;26:e01355. Epub 2021 Nov 29.

Neurosurgery Department, Bonifatius Hospital, Lingen, Germany.

The maternal death rate remains unacceptably high worldwide, predominantly in areas of poor access to quality health services. According to the WHO, in 2017, 810 women died from preventable causes related to pregnancy and childbirth. Causes of maternal death are plenty, including previous morbidity and unexpected causes. Read More

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November 2021

Atraumatic myonecrosis presenting as upper limb ischaemia in a patient with undiagnosed bowel cancer.

Ann R Coll Surg Engl 2022 Apr 26;104(4):e95-e97. Epub 2021 Nov 26.

Cambridge University Hospitals NHS Foundation Trust, UK.

Necrotising infections remain challenging to surgeons, both in diagnosis and management. Timely recognition and treatment remain vital. We report a presentation of limb ischaemia with no apparent precipitating factors, in a systemically stable patient, due to atraumatic myonecrosis. Read More

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Learning from Nature: Bacterial Spores as a Target for Current Technologies in Medicine (Review).

Sovrem Tekhnologii Med 2021 28;12(3):105-122. Epub 2020 Jun 28.

Researcher, Laboratory of Molecular Microbiology G.P. Somov Institute of Epidemiology and Microbiology, 1 Selskaya St., Vladivostok, 690087, Russia.

The capability of some representatives of . and . genera to form spores in extreme external conditions long ago became a subject of medico-biological investigations. Read More

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[Study on the interaction between Clostridium perfringens and the host].

Masaya Takehara

Nihon Saikingaku Zasshi 2021 ;76(3):149-160

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

Clostridium perfringens type A causes gas gangrene, which is a serious disease caused by wound infection. α-Toxin produced by C. perfringens is known to be the primary pathogenic factor of gas gangrene. Read More

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November 2021

Dietary Supplementation With Ameliorates Compromise of Growth Performance by Modulating Short-Chain Fatty Acids and Intestinal Dysbiosis in Broilers Under Challenge.

Front Nutr 2021 14;8:706148. Epub 2021 Oct 14.

Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China) of the Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang, College of Animal Sciences, Institute of Animal Nutrition and Feed Sciences, Zhejiang University, Hangzhou, China.

is an important zoonotic pathogen associated with food contamination and poisoning, gas gangrene, necrotizing enterocolitis or necrotic enteritis in humans and animals. Dysbacteriosis is supposedly associated with the development of infection induced necrotic enteritis, but the detailed relationship between intestinal health, microbiome, and infection-induced necrotic enteritis remains poorly understood. This research investigated the effect of probiotics on the growth performance and intestinal health of broilers, and the involved roles of intestinal microbiota and microbial metabolic functions under infection. Read More

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October 2021

necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection.

Access Microbiol 2021 15;3(9):000261. Epub 2021 Sep 15.

Department of General and Visceral Surgery, Hospital Universitario Príncipe de Asturias, Spain.

Pancreatic necrosis infection (PNI) accounts for about 20-40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present, is the microorganism most commonly involved. We present a 60-year-old patient with a previous history of SARS-CoV-2, diagnosed with acute pancreatitis. Read More

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September 2021

Coinfection of Clostridium perfringens and Escherichia coli in gas-producing perianal abscess diagnosed by 16S rDNA sequencing: a case report.

Gut Pathog 2021 Oct 13;13(1):61. Epub 2021 Oct 13.

Division of Clinical Laboratory, the Second Hospital of Jilin University, Changchun, Jilin, China.

Background: Gas-producing perianal abscess raises the possibility of clostridial infection, with Clostridium perfringens being the most common causative agent, which is highly lethal if untreated timely. As the treatment of clostridial infections often differs from that of non-clostridial infections, which they may closely resemble, the importance of accurate pathogenic organism identification cannot be overemphasized. The 16S rDNA of bacteria is highly conserved within a species and among species of the same genus but demonstrates substantial variation between different species, thus making it a suitable genomic candidate for bacterial detection and identification. Read More

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October 2021

Primary abdominal gas gangrene: a report of two autopsy cases.

Autops Case Rep 2021 23;11:e2021329. Epub 2021 Sep 23.

Medical University - Varna "Prof. Dr. Paraskev Stoyanov", Faculty of Medicine, Department of General and Clinical Pathology, Forensic Medicine and Deontology, Varna, Bulgaria.

Primary hepatic gas gangrene is a form of primary abdominal gas gangrene. The condition is caused by , other clostridia, and non-clostridia bacterial species producing gas. Unlike classical gas gangrene or myonecrosis, the disease develops without a wound or a port of entry. Read More

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September 2021

Fatal Clostridium septicum myonecrosis from gastric perforation: A case report.

Anaerobe 2021 Dec 25;72:102445. Epub 2021 Sep 25.

Northern Light AR Gould Hospital, 140 Academy Street, Presque Isle, ME, 04769, USA.

Clostridial myonecrosis is a medical and surgical emergency which requires early and aggressive intervention to reduce mortality. We report a rare case of Clostridium septicum myonecrosis that disseminated hematogenously from a gastric perforation. The patient was afebrile and hemodynamically stable upon admission. Read More

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December 2021

Clostridium septicum-induced gangrene in the right lower extremity complicating pneumatosis in the right ventricle and the pulmonary artery and occlusion of right femoral artery: a case report.

BMC Infect Dis 2021 Sep 16;21(1):957. Epub 2021 Sep 16.

Department of Intensive Care Unit, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Gas gangrene is usually manifested as myonecrosis and subcutaneous gas accumulation, but rarely manifested as arterial occlusion or pneumatosis in the right ventricle and the pulmonary artery.

Case Presentation: We report a case of gas gangrene caused by Clostridium septicum. The patient developed gas gangrene after being pecked by a chicken but turned for the better following antibiotic treatment and debriment. Read More

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September 2021

Animal-related factors predicting fatal cases of blackleg and gas gangrene in cattle.

Vet Rec 2021 Nov 9;189(10):e558. Epub 2021 Jun 9.

Unit of Veterinary Public Health and Epidemiology, Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.

Background: Blackleg and gas gangrene are acute clostridial infections primarily affecting cattle. The objectives of this study were to identify (i) animal-related factors influencing the occurrence and (ii) prognostic pathological findings supporting the differentiation of fatal blackleg and gas gangrene cases in the cattle population from 1998 to 2018 in Styria, Austria.

Methods: Two binomial logistic models were applied to analyse the research questions. Read More

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November 2021

Large Clostridial Toxins: Mechanisms and Roles in Disease.

Microbiol Mol Biol Rev 2021 08 2;85(3):e0006421. Epub 2021 Jun 2.

Molecular Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB, Paeniclostridium sordellii toxins TcsL and TcsH, Clostridium novyi toxin TcnA, and Clostridium perfringens toxin TpeL. Since the 19th century, LCT-secreting bacteria have been isolated from the blood, organs, and wounds of diseased individuals, and LCTs have been implicated as the primary virulence factors in a variety of infections, including C. Read More

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Gas Gangrene Following Posterior Tibial Tendon Transfer of a 34-Year-Old Patient - a Case Report.

Acta Chir Plast 2021 ;63(1):18-22

Gas gangrene is a rare and potentially fatal surgical complication, most often associated with contaminated traumatic wounds or more rarely following cases of abdominal surgery. The following article describes a case of gas gangrene in the right lower limb of a 34-year-old patient following an elective posterior tibial tendon transfer. The surgery was performed in bloodless fashion, utilizing a surgical tourniquet. Read More

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Rapidly progressive and fatal distant spontaneous gas gangrene due to after biopsy of malignant cecal mass.

IDCases 2021 22;24:e01129. Epub 2021 Apr 22.

University of California, San Francisco, 155 N Fresno St, Suite 307, Fresno, CA, 93701, United States.

species are known to cause myonecrosis and gas gangrene which are often fatal infections in the setting of trauma but also spontaneously in certain populations such as colorectal malignancy, immunosuppression, and neutropenia. We report a case of an 83-year-old male who developed fatal and rapidly progressive gas gangrene due to within 48 h after biopsy of suspected malignant cecal mass. To our knowledge, such a drastic, rapid and fatal presentation after a diagnostic biopsy of malignant mass has not been previously reported and is something to be watchful for in suspected colon cancer cases. Read More

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Vaccination against pathogenic clostridia in animals: a review.

Trop Anim Health Prod 2021 Apr 23;53(2):284. Epub 2021 Apr 23.

Department of Anaerobic Vaccine Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Shahid Beheshti Blvd., P.O. Box: 31975/148, Hesarak, Karaj, Alborz Province, Iran.

Clostridium is a Gram-positive, rod-shaped, anaerobic, and spore-forming bacterium, which is found in the surrounding environments throughout the world. Clostridium species cause botulism, tetanus, enterotoxaemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease. Clostridium infection causes severe economic losses in livestock and poultry industries. Read More

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