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    1256 results match your criteria Clostridial Gas Gangrene

    1 OF 26

    Ethanolamine utilization supports Clostridium perfringens growth in infected tissues.
    Microb Pathog 2018 Apr 11;119:200-207. Epub 2018 Apr 11.
    Department of Microbiology, Faculty of Medicine, Kagawa University, 1750-1 Miki, Kagawa, 761-0793, Japan. Electronic address:
    Clostridium perfringens possesses the ethanolamine (EA) utilization (eut) system encoded within the eut operon, which utilizes the EA as a carbon, nitrogen and energy source. To determine the role of the eut system in C. perfringens growth, an in-frame deletion of the eutABC genes was made in strain HN13 to generate the eutABC-deleted mutant strain HY1701. Read More

    Concurrent Host-Pathogen Transcriptional Responses in a Murine Myonecrosis Infection.
    MBio 2018 Mar 27;9(2). Epub 2018 Mar 27.
    Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia
    To obtain an insight into host-pathogen interactions in clostridial myonecrosis, we carried out comparative transcriptome analysis of both the bacterium and the host in a murine infection model, which is the first time that such an investigation has been conducted. Analysis of the host transcriptome from infected muscle tissues indicated that many genes were upregulated compared to the results seen with mock-infected mice. These genes were enriched for host defense pathways, including Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling components. Read More

    Atraumatic Clostridial Myonecrosis in an Immunocompromised Host.
    J Emerg Med 2018 Mar 10. Epub 2018 Mar 10.
    Division of Community Internal Medicine, Mayo Clinic, Jacksonville, Florida.
    Background: Necrotizing fasciitis is usually associated with a surgical or traumatic wound. Clostridial myonecrosis is an uncommon but deadly infection that can develop in the absence of a wound and is often associated with occult gastrointestinal cancer or immunocompromise, or both.

    Case Report: We report a case of catastrophic atraumatic Clostridium septicum infection in an immunocompromised host. Read More

    Sliding free transverse rectus abdominis myocutaneous flap for closure of a massive abdominal wall defect: A case report.
    Microsurgery 2018 Feb 16. Epub 2018 Feb 16.
    Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Heidelberg, Germany.
    Despite considerable advances in reconstructive surgery, massive abdominal wall defects continue to pose a significant surgical challenge. We report the case of a 72-year-old morbidly obese female patient with Clostridium septicum-related gas gangrene of the abdominal wall. After multidisciplinary treatment and multiple extensive debridements, a massive full-thickness defect (40 cm × 35 cm) of the right abdominal wall was present. Read More

    Metabolic dependent and independent pH-drop shuts down VirSR quorum sensing in Clostridium perfringens.
    J Biosci Bioeng 2018 Jan 17. Epub 2018 Jan 17.
    Laboratory of Microbial Technology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan. Electronic address:
    Clostridium perfringens produces various exotoxins and enzymes that cause food poisoning and gas gangrene. The genes involved in virulence are regulated by the agr-like quorum sensing (QS) system, which consists of a QS signal synthesis system and a VirSR two-component regulatory system (VirSR TCS) which is a global regulatory system composed of signal sensor kinase (VirS) and response regulator (VirR). We found that the perfringolysin O gene (pfoA) was transiently expressed during mid-log phase of bacterial growth; its expression was rapidly shut down thereafter, suggesting the existence of a self-quorum quenching (sQQ) system. Read More

    Immunization with a nontoxic naturally occurring Clostridium perfringens alpha toxin induces neutralizing antibodies in rabbits.
    Anaerobe 2018 Feb 12;49:48-52. Epub 2017 Dec 12.
    Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:
    Clostridium perfringens alpha toxin, encoded by plc gene, has been implicated in gas gangrene, a life threatening infection. Vaccination is considered one of the best solutions against Clostridium infections. Although studies have identified many low quality clostridial vaccines, the use of recombinant proteins has been considered a promising alternative. Read More

    Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model.
    Toxicon 2018 Jan 12;141:112-117. Epub 2017 Dec 12.
    Department of Pharmacology, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. Electronic address:
    Cases of Clostridium perfringens septicemia, such as liver abscess, often develop a rapidly progressive intravascular hemolysis and coagulation; the mortality rate with current standard care including antibiotics and surgery is high. Herein, we firstly investigated the effects of gas gangrene antitoxin (GGA) (antitoxin against C. perfringens) and recombinant human soluble thrombomodulin (rTM) on the hemolysis, coagulation status, inflammatory process, and mortality in α-toxin-treated rats. Read More

    Complete genome sequences of Del1 strain isolated from chickens affected by necrotic enteritis.
    Gut Pathog 2017 21;9:69. Epub 2017 Nov 21.
    Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-US Department of Agriculture, Beltsville, 10300 Baltimore Avenue, MD 20705 USA.
    Background: is ubiquitous in nature. It is a normal inhabitant in the intestinal tract of animals and humans. As the primary etiological agent of gas gangrene, necrosis and bacteremia, causes food poisoning, necrotic enteritis (NE), and even death. Read More

    Deadly combination: and colorectal malignancy.
    BMJ Case Rep 2017 Dec 2;2017. Epub 2017 Dec 2.
    General Surgery, University Hospital Limerick, Limerick, Ireland.
    Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated is a rare cause of gas gangrene. This case outlines an initial presentation of colonic malignancy as gas gangrene from infection. Read More

    Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report.
    J Med Case Rep 2017 Nov 28;11(1):332. Epub 2017 Nov 28.
    Department of Surgery, University of Illinois at Chicago, Chicago, 60612, IL, USA.
    Background: Fusobacterium necrophorum is a common agent of disease in humans, but the occurrence of primary infections outside the head and neck area is extremely rare. While infection with Fusobacterium necrophorum has a rather benign course above the thorax, the organism is capable of producing very severe disease when located in unusual sites, including various forms of septic thrombophlebitis. No infections of the leg have been documented before; thus, antibiotic coverage for Fusobacterium is currently not recommended in this area. Read More

    Liver abscess and sepsis caused by Clostridium perfringens and Klebsiella oxytoca.
    Int J Surg Case Rep 2017 5;41:180-183. Epub 2017 Nov 5.
    Department of General, Visceral and Cancer Surgery, HELIOS Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany. Electronic address:
    Introduction: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i. Read More

    Uterine infection related to gynecologic malignancy.
    Gynecol Oncol Rep 2017 Nov 21;22:55-57. Epub 2017 Sep 21.
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, United States.
    Uterine gas gangrene caused by is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality. Read More

    Rare postoperative complication: septic shock following elective abdominal surgery.
    BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.
    Department of General Surgery, Bedford Hospital NHS Trust, Bedford, UK.
    Postoperative infections are one of the most common complications in general surgery, and while rates have reduced with the routine administration of perioperative antibiotics, around 5% of patients undergoing a surgical procedure will develop an infective complication. The Gram-positive, obligate anaerobe, , is a well-known pathogen that forms part of both the environmental and gastrointestinal flora. While more commonly associated with food poisoning, anaerobic cellulitis and traumatic gas gangrene, rare cases of spontaneous non-traumatic gas gangrene of abdominal viscera have also been recorded. Read More

    Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors.
    Int J Biol Macromol 2018 Feb 6;107(Pt B):1491-1500. Epub 2017 Oct 6.
    Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India. Electronic address:
    Metalloproteases are a class of proteases having metal ion(s) at their catalytic sites. Bacterial collagenases are involved in human gas gangrene, periodontal diseases, food etc. The Clostridium collagenase occurs in two isoforms COL_G and Col_H. Read More

    Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat.
    Cureus 2017 Jul 13;9(7):e1469. Epub 2017 Jul 13.
    Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentation to be reported in literature. Read More

    Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A.
    PLoS One 2017 21;12(9):e0185215. Epub 2017 Sep 21.
    Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing, China.
    NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. Read More

    Spontaneous C. septicum gas gangrene: A literature review.
    Anaerobe 2017 Dec 2;48:165-171. Epub 2017 Aug 2.
    Boise VA Medical Center, Boise, ID 83702, USA. Electronic address:
    As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. Read More

    Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland.
    Pol J Microbiol 2017 Jan;65(4):399-406
    Department of Infection Epidemiology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
    The objective of the study was to perform a comparative analysis of phenotypic and genetic similarity, determination of resistance profiles, detection of toxin-encoding genes and molecular typing of Clostridium perfringens isolates originating from patients with gas gangrene. The study encompassed three patients with a clinical and microbiological diagnosis of gas gangrene who were hospitalized in one of the hospitals of the Kujawsko-Pomorskie province in the same period of time between 8 April 2015 and 20 April 2015. The three C. Read More

    Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities.
    Curr Microbiol 2017 Nov 21;74(11):1278-1286. Epub 2017 Jul 21.
    Haffkine Biopharmaceutical Corporation Limited, Pune, India.
    Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities. Read More

    A rapid qualitative assay for detection of Clostridium perfringens in canned food products.
    Acta Biochim Pol 2017 9;64(2):207-213. Epub 2017 Jun 9.
    Department of Biotechnology, P D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa-388421, India.
    Clostridium perfringens (MTCC 1349) is a Gram-positive, anaerobic, endospore forming, and rod-shaped bacterium. This bacterium produces a variety of toxins under strict anaerobic environment. C. Read More

    Complete genome sequence of CBA7123 isolated from a faecal sample from Korea.
    Gut Pathog 2017 2;9:32. Epub 2017 Jun 2.
    Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755 Republic of Korea.
    Background: is an opportunistic human pathogen that causes necrotic enteritis, mild diarrhea, clostridial myonecrosis or gas gangrene, sepsis, etc. In this study, we aim to determine the pathogenesis of this bacterium at the genomic level. The genome of strain CBA7123 was sequenced, and a comparative genomic analysis between strain CBA7123 and four other related strains was performed. Read More

    A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens α-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
    Probiotics Antimicrob Proteins 2017 Apr 11. Epub 2017 Apr 11.
    Department of Anaerobic Bacterial Vaccine Research and Production, Kerman Branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran.
    The alpha-toxin is one of the virulence factors of Clostridium perfringens for gas gangrene in humans and animals or necrotic enteritis in poultry. The C-terminal domain of this toxin ( cpa ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid. This surface-expressing plasmid was electroporated into Lactobacillus casei ATCC 393, generating the recombinant L. Read More

    Identification, Isolation, and Phylogenetic Analysis of Clostridium perfringens Type A and Type C from Wild Boar ( Sus scrofa ) in the People's Republic of China.
    J Wildl Dis 2017 Jul 22;53(3):642-648. Epub 2017 Mar 22.
    1 National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China 100101.
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). Read More

    A fatal Clostridium perfringens infection with hemolysis after chemotherapy in an adolescent.
    Arch Argent Pediatr 2017 04;115(2):e92-e95
    Department of Pediatrics, Pediatric Intensive Care Unit, Faculty of Medicine, Hacettepe University.
    Gas gangrene, clostridial myonecrosis, is one of the most serious infectious diseases, characterized by rapidly progressive destruction of deep soft tissues and production of gas within the tissues. We presented a case of fatal spontaneous gas gangrene due to Clostridium perfringens in a patient with acute lymphoblastic leukemia during remission induction chemotherapy phase. Read More

    [Necrotizing fasciitis of the upper and lower extremities].
    Chirurg 2017 Apr;88(4):353-366
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie-Zentrum, operatives Referenzzentrum für Gliedmaßentumoren, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.
    Necrotizing fasciitis is a potentially fatal soft tissue infection that may affect the upper and lower extremities, scrotum, perineum and abdominal wall. Typically, the infection demonstrates rapid spreading along the fascial planes leading to sepsis with mortality rates of 15-46%. Without adequate treatment, the mortality rate increases to close to 100%. Read More

    Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
    Toxicon 2017 May 1;130:79-86. Epub 2017 Mar 1.
    Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, Jilin Province, China. Electronic address:
    Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered a potential bioterrorism threat. To date, there is still no human effective therapeutic drug against alpha-toxin. Read More

    Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model.
    Folia Microbiol (Praha) 2017 Jul 17;62(4):343-353. Epub 2017 Feb 17.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, 474002, India.
    Clostridium perfringens is a Validated Biological Agent and a pathogen of medical, veterinary, and military significance. Gas gangrene is the most destructive of all the clostridial diseases and is caused by C. perfringens type A strains wherein the infection spreads quickly (several inches per hour) with production of gas. Read More

    Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis.
    Vet Res 2017 02 16;48(1). Epub 2017 Feb 16.
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.
    Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small intestinal haemorrhage, necrosis and mucosal neutrophil infiltration. The common assumption that, when causing intestinal disease, C. Read More

    Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.
    Chem Phys Lipids 2017 Mar 16;203:54-70. Epub 2017 Jan 16.
    Unidad de Biofísica (CSIC, UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain. Electronic address:
    Clostridium perfringens alpha-toxin (ATX) is considered as a prototype of cytotoxic bacterial phospholipases C, and is the major virulence factor in C. perfringens-induced gas gangrene. It is known that, depending on the dose, ATX causes membrane disruption and cytolysis or only limited hydrolysis of its substrates. Read More

    Role of p38 MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 12 22;9(1). Epub 2016 Dec 22.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. Read More

    Clostridium perfringens: a rare cause of spondylodiscitis case report and review of the literature.
    Br J Neurosurg 2016 Dec 14:1-3. Epub 2016 Dec 14.
    a Department of Orthopaedic , Study Conducted at the University Hamburg Eppendorf , Hamburg , Germany.
    Presented is a case of a 64-year old male with a unique and yet unreported case of a spondylodiscitis caused by Clostridium perfringens. Becoming symptomatic with massive neurological deficits. Computed tomography (CT) revealed typical signs of spondylodiscitis involving the vertebral body L5 with extensive vacuum phenomenon. Read More

    Fulminant Clostridium perfringens Sepsis in Kidney Transplant: A Case Report.
    Transplant Proc 2016 Nov;48(9):3112-3114
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
    Background: Infections, particularly urinary tract infections, and cardiovascular accidents are the main causes of morbidity and mortality during the 1st year after kidney transplantation (KT). Bacteria and viruses, such as Escherichia coli, Enteroccoci, and Polyoma BK virus are common in the 1st 6 months, so they are controlled routinely. On the other hand, Clostridium perfringens infection is a rare life-threatening condition, associated with a high mortality rate especially in the transplant population, that is not controlled routinely. Read More

    Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.
    Toxins (Basel) 2016 11 21;8(11). Epub 2016 Nov 21.
    Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas, Pelotas CEP 96160-000, Rio Grande do Sul, Brazil.
    is a spore-forming, commensal, ubiquitous bacterium that is present in the gastrointestinal tract of healthy humans and animals. This bacterium produces up to 18 toxins. The species is classified into five toxinotypes (A-E) according to the toxins that the bacterium produces: alpha, beta, epsilon, or iota. Read More

    Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets.
    Toxins (Basel) 2016 11 19;8(11). Epub 2016 Nov 19.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Room 420, Bridgeside Point II Building, 450 Technology Drive, Pittsburgh, PA 15219, USA.
    is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. Read More

    Georgian Med News 2016 Sep(258):73-76
    Tbilisi State Medical University; The First University Clinic, Georgia.
    Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. Read More

    Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils.
    Biol Pharm Bull 2016 ;39(10):1694-1700
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
    Clostridium perfringens type A, a Gram-positive, anaerobic bacterium, causes gas gangrene. Recently, we reported that C. perfringens α-toxin blocked neutrophil differentiation in an enzyme activity-dependent manner to impair host innate immunity, which should be crucial for the pathogenesis of C. Read More

    : An Unusual Link to a Lower Gastrointestinal Bleed.
    Case Rep Gastroenterol 2016 May-Aug;10(2):489-493. Epub 2016 Sep 12.
    Gastroenterology Division, Department of Medicine, SUNY Upstate Medical University, Syracuse, N.Y., USA.
    is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. Presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. We report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. Read More

    Fatal Clostridium perfringens Septicemia After Colonoscopic Polypectomy, Without Bowel Perforation.
    J Forensic Sci 2016 Nov 22;61(6):1689-1692. Epub 2016 Sep 22.
    Section of Legal Medicine, University of Perugia, via T. di Joannuccio snc, Terni, 05100, Italy.
    Since its introduction, colonoscopy has played an important role as a diagnostic, therapeutic, and screening tool. In general, colonoscopy is regarded as a safe procedure, but complications may occur. The most dreaded of these complications is colonic perforation. Read More

    The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.
    PLoS One 2016 16;11(9):e0162981. Epub 2016 Sep 16.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
    The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capable of utilizing both human hemoglobin and ferric chloride, but not human holo-transferrin, as an iron source for in vitro growth. Read More

    Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review.
    Surg Laparosc Endosc Percutan Tech 2016 Aug;26(4):278-81
    Department of Surgery, MC Slotervaart, Amsterdam, The Netherlands.
    Clostridial gas gangrene is a rare, yet severe, complication after laparoscopic cholecystectomy. We present a case report of a 48-year-old man with obesity, coronary artery disease, and diabetes, who developed clostridial gas gangrene of the abdominal wall after an uncomplicated laparoscopic cholecystectomy. Although the diagnosis was missed initially, successful radical surgical debridement was performed and the patient survived. Read More

    A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.
    BMC Res Notes 2016 Aug 3;9:385. Epub 2016 Aug 3.
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Gas gangrene is a necrotic infection of soft tissue associated with high mortality rates. We report a case of postoperative gas gangrene with very acute onset and rapid progression of symptoms. To our knowledge, this case is the most acute onset of postoperative gas gangrene ever reported. Read More

    Regulation of Toxin Production in Clostridium perfringens.
    Toxins (Basel) 2016 07 5;8(7). Epub 2016 Jul 5.
    Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
    The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. Read More

    Putative function of hypothetical proteins expressed by Clostridium perfringens type A strains and their protective efficacy in mouse model.
    Infect Genet Evol 2016 10 21;44:147-56. Epub 2016 Jun 21.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior 474002, India.
    The whole genome sequencing and annotation of Clostridium perfringens strains revealed several genes coding for proteins of unknown function with no significant similarities to genes in other organisms. Our previous studies clearly demonstrated that hypothetical proteins CPF_2500, CPF_1441, CPF_0876, CPF_0093, CPF_2002, CPF_2314, CPF_1179, CPF_1132, CPF_2853, CPF_0552, CPF_2032, CPF_0438, CPF_1440, CPF_2918, CPF_0656, and CPF_2364 are genuine proteins of C. perfringens expressed in high abundance. Read More

    Uterine Perforation with Intra-Abdominal Gas Gangrene: A Rare and Fatal Infection.
    J Gynecol Surg 2016 Jun;32(3):182-184
    Richmond University Medical Center , Staten Island, NY.
    gas gangrene is an extremely rare and fatal infection. Necrosis of the myometrium is rarely seen and has only been recorded in 18 cases to date. Of these 18 reported cases, only 5 have occurred in nonpregnant women. Read More

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