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    1223 results match your criteria Clostridial Gas Gangrene

    1 OF 25

    A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens α-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
    Probiotics Antimicrob Proteins 2017 Apr 11. Epub 2017 Apr 11.
    Department of Anaerobic Bacterial Vaccine Research and Production, Kerman Branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran.
    The alpha-toxin is one of the virulence factors of Clostridium perfringens for gas gangrene in humans and animals or necrotic enteritis in poultry. The C-terminal domain of this toxin ( cpa 247-370 ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid. This surface-expressing plasmid was electroporated into Lactobacillus casei ATCC 393, generating the recombinant L. Read More

    Identification, Isolation, and Phylogenetic Analysis of Clostridium perfringens Type A and Type C from Wild Boar ( Sus scrofa ) in the People's Republic of China.
    J Wildl Dis 2017 Mar 22. Epub 2017 Mar 22.
    1 National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China, 100101.
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). Read More

    A fatal Clostridium perfringens infection with hemolysis after chemotherapy in an adolescent.
    Arch Argent Pediatr 2017 Apr;115(2):e92-e95
    Department of Pediatrics, Pediatric Intensive Care Unit, Faculty of Medicine, Hacettepe University.
    Gas gangrene, clostridial myonecrosis, is one of the most serious infectious diseases, characterized by rapidly progressive destruction of deep soft tissues and production of gas within the tissues. We presented a case of fatal spontaneous gas gangrene due to Clostridium perfringens in a patient with acute lymphoblastic leukemia during remission induction chemotherapy phase. Read More

    [Necrotizing fasciitis of the upper and lower extremities].
    Chirurg 2017 Apr;88(4):353-366
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie-Zentrum, operatives Referenzzentrum für Gliedmaßentumoren, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.
    Necrotizing fasciitis is a potentially fatal soft tissue infection that may affect the upper and lower extremities, scrotum, perineum and abdominal wall. Typically, the infection demonstrates rapid spreading along the fascial planes leading to sepsis with mortality rates of 15-46%. Without adequate treatment, the mortality rate increases to close to 100%. Read More

    Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
    Toxicon 2017 May 1;130:79-86. Epub 2017 Mar 1.
    Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, Jilin Province, China. Electronic address:
    Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered a potential bioterrorism threat. To date, there is still no human effective therapeutic drug against alpha-toxin. Read More

    Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model.
    Folia Microbiol (Praha) 2017 Feb 17. Epub 2017 Feb 17.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, 474002, India.
    Clostridium perfringens is a Validated Biological Agent and a pathogen of medical, veterinary, and military significance. Gas gangrene is the most destructive of all the clostridial diseases and is caused by C. perfringens type A strains wherein the infection spreads quickly (several inches per hour) with production of gas. Read More

    Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.
    Chem Phys Lipids 2017 Mar 16;203:54-70. Epub 2017 Jan 16.
    Unidad de Biofísica (CSIC, UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain. Electronic address:
    Clostridium perfringens alpha-toxin (ATX) is considered as a prototype of cytotoxic bacterial phospholipases C, and is the major virulence factor in C. perfringens-induced gas gangrene. It is known that, depending on the dose, ATX causes membrane disruption and cytolysis or only limited hydrolysis of its substrates. Read More

    Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 Dec 22;9(1). Epub 2016 Dec 22.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. Read More

    Clostridium perfringens: a rare cause of spondylodiscitis case report and review of the literature.
    Br J Neurosurg 2016 Dec 14:1-3. Epub 2016 Dec 14.
    a Department of Orthopaedic , Study Conducted at the University Hamburg Eppendorf , Hamburg , Germany.
    Presented is a case of a 64-year old male with a unique and yet unreported case of a spondylodiscitis caused by Clostridium perfringens. Becoming symptomatic with massive neurological deficits. Computed tomography (CT) revealed typical signs of spondylodiscitis involving the vertebral body L5 with extensive vacuum phenomenon. Read More

    Fulminant Clostridium perfringens Sepsis in Kidney Transplant: A Case Report.
    Transplant Proc 2016 Nov;48(9):3112-3114
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
    Background: Infections, particularly urinary tract infections, and cardiovascular accidents are the main causes of morbidity and mortality during the 1st year after kidney transplantation (KT). Bacteria and viruses, such as Escherichia coli, Enteroccoci, and Polyoma BK virus are common in the 1st 6 months, so they are controlled routinely. On the other hand, Clostridium perfringens infection is a rare life-threatening condition, associated with a high mortality rate especially in the transplant population, that is not controlled routinely. Read More

    Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.
    Toxins (Basel) 2016 Nov 21;8(11). Epub 2016 Nov 21.
    Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas, Pelotas CEP 96160-000, Rio Grande do Sul, Brazil.
    Clostridium perfringens is a spore-forming, commensal, ubiquitous bacterium that is present in the gastrointestinal tract of healthy humans and animals. This bacterium produces up to 18 toxins. The species is classified into five toxinotypes (A-E) according to the toxins that the bacterium produces: alpha, beta, epsilon, or iota. Read More

    Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets.
    Toxins (Basel) 2016 Nov 19;8(11). Epub 2016 Nov 19.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Room 420, Bridgeside Point II Building, 450 Technology Drive, Pittsburgh, PA 15219, USA.
    Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. Read More

    CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT).
    Georgian Med News 2016 Sep(258):73-76
    Tbilisi State Medical University; The First University Clinic, Georgia.
    Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. Read More

    Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils.
    Biol Pharm Bull 2016 ;39(10):1694-1700
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
    Clostridium perfringens type A, a Gram-positive, anaerobic bacterium, causes gas gangrene. Recently, we reported that C. perfringens α-toxin blocked neutrophil differentiation in an enzyme activity-dependent manner to impair host innate immunity, which should be crucial for the pathogenesis of C. Read More

    Clostridium septicum: An Unusual Link to a Lower Gastrointestinal Bleed.
    Case Rep Gastroenterol 2016 May-Aug;10(2):489-493. Epub 2016 Sep 12.
    Gastroenterology Division, Department of Medicine, SUNY Upstate Medical University, Syracuse, N.Y., USA.
    Clostridium septicum is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. Presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. We report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. Read More

    Fatal Clostridium perfringens Septicemia After Colonoscopic Polypectomy, Without Bowel Perforation.
    J Forensic Sci 2016 Nov 22;61(6):1689-1692. Epub 2016 Sep 22.
    Section of Legal Medicine, University of Perugia, via T. di Joannuccio snc, Terni, 05100, Italy.
    Since its introduction, colonoscopy has played an important role as a diagnostic, therapeutic, and screening tool. In general, colonoscopy is regarded as a safe procedure, but complications may occur. The most dreaded of these complications is colonic perforation. Read More

    The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.
    PLoS One 2016 16;11(9):e0162981. Epub 2016 Sep 16.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
    The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capable of utilizing both human hemoglobin and ferric chloride, but not human holo-transferrin, as an iron source for in vitro growth. Read More

    Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review.
    Surg Laparosc Endosc Percutan Tech 2016 Aug;26(4):278-81
    Department of Surgery, MC Slotervaart, Amsterdam, The Netherlands.
    Clostridial gas gangrene is a rare, yet severe, complication after laparoscopic cholecystectomy. We present a case report of a 48-year-old man with obesity, coronary artery disease, and diabetes, who developed clostridial gas gangrene of the abdominal wall after an uncomplicated laparoscopic cholecystectomy. Although the diagnosis was missed initially, successful radical surgical debridement was performed and the patient survived. Read More

    A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.
    BMC Res Notes 2016 Aug 3;9:385. Epub 2016 Aug 3.
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Gas gangrene is a necrotic infection of soft tissue associated with high mortality rates. We report a case of postoperative gas gangrene with very acute onset and rapid progression of symptoms. To our knowledge, this case is the most acute onset of postoperative gas gangrene ever reported. Read More

    Regulation of Toxin Production in Clostridium perfringens.
    Toxins (Basel) 2016 Jul 5;8(7). Epub 2016 Jul 5.
    Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
    The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. Read More

    Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection.
    J Gynecol Surg 2016 Jun;32(3):182-184
    Richmond University Medical Center , Staten Island, NY.
    Background:Clostridium perfringens gas gangrene is an extremely rare and fatal infection. Necrosis of the myometrium is rarely seen and has only been recorded in 18 cases to date. Of these 18 reported cases, only 5 have occurred in nonpregnant women. Read More

    Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.
    Int J Med Microbiol 2016 Sep 20;306(6):429-42. Epub 2016 May 20.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that causes human gas gangrene (clostridial myonecrosis) and food poisoning. Early studies showed that virulence was regulated by the VirSR two-component signal transduction system. However, our identification of the RevR orphan response regulator indicated that more than one system was involved in controlling virulence. Read More

    Massive gas gangrene secondary to occult colon carcinoma.
    Radiol Case Rep 2016 Jun 5;11(2):67-9. Epub 2016 Mar 5.
    Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710, USA.
    Gas gangrene is a rare but often fatal soft-tissue infection. Because it is uncommon and the classic symptom of crepitus does not appear until the infection is advanced, prompt diagnosis requires a high index of suspicion. We present a case report of a middle-aged man who presented with acute onset lower-extremity pain that was initially thought to be due to deep vein thrombosis. Read More

    RNA-seq analysis of virR and revR mutants of Clostridium perfringens.
    BMC Genomics 2016 May 23;17:391. Epub 2016 May 23.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, 3800, Australia.
    Background: Clostridium perfringens causes toxin-mediated diseases, including gas gangrene (clostridial myonecrosis) and food poisoning in humans. The production of the toxins implicated in gas gangrene, α-toxin and perfringolysin O, is regulated by the VirSR two-component regulatory system. In addition, RevR, an orphan response regulator, has been shown to affect virulence in the mouse myonecrosis model. Read More

    Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 Apr 13;8(4):109. Epub 2016 Apr 13.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the "Large clostridial glycosylating toxins." These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by exploiting UDP-glucose as a hexose donor. TcsL is casually involved in the toxic shock syndrome and the gas gangrene. Read More

    Clostridium Perfringens Infection in a Febrile Patient with Severe Hemolytic Anemia.
    Am J Case Rep 2016 Apr 6;17:219-23. Epub 2016 Apr 6.
    Department of Emergency and Acute Intensive Care Medicine, Aichi Medical University, Nagakute, Japan.
    Background: Clostridium perfringens (C. perfringens) can cause various infections, including gas gangrene, crepitant cellulitis, and fasciitis. While C. Read More

    Fatal Clostridium perfringens sepsis due to emphysematous gastritis and literature review.
    Anaerobe 2016 Aug 30;40:31-4. Epub 2016 Mar 30.
    Department of Clinical Microbiology, University of Szeged, Szeged, Hungary.
    A 76-year-old female patient was admitted to the Level I Emergency Department of University of Szeged with severe abdominal pain and vomiting. The clinical assessment with laboratory tests and radiological investigations confirmed severe sepsis associated with intravascular hemolysis and multiorgan failure and acute pancreatitis. On the abdominal CT, besides of other abnormalities, the presence of gas bubbles in the stomach, small intestines and liver were seen. Read More

    Optimization of the Production of Inactivated Clostridium novyi Type B Vaccine Using Computational Intelligence Techniques.
    Appl Biochem Biotechnol 2016 Jul 22;179(5):895-909. Epub 2016 Mar 22.
    Programa de Pós-Graduação em Engenharia Química, UFSCar, Federal University of Sao Carlos, Rodovia Washington Luís, km 235, 13565-905, Monjolinho - São Carlos, São Paulo, Brazil.
    Clostridium novyi causes necrotic hepatitis in sheep and cattle, as well as gas gangrene. The microorganism is strictly anaerobic, fastidious, and difficult to cultivate in industrial scale. C. Read More

    Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis.
    Case Rep Infect Dis 2015 17;2015:694247. Epub 2015 Dec 17.
    Department of Internal Hospital Medicine, H. Lee Moffitt Cancer Center, Tampa, FL 33612-9416, USA; USF College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612-9416, USA.
    The Clostridia species are responsible for some of the deadliest diseases including gas gangrene, tetanus, and botulism. Clostridium septicum is a rare subgroup known to cause atraumatic myonecrosis and is associated with colonic malignancy or immunosuppression. It is a Gram-positive, anaerobic, spore-forming bacillus found in the gastrointestinal tract and can lead to direct, spontaneous infections of the bowel and peritoneal cavity. Read More

    Clostridium septicum aortitis and colon carcinoma.
    J Cardiovasc Comput Tomogr 2016 May-Jun;10(3):258-60. Epub 2016 Jan 8.
    Thomas Jefferson University Hospital, Department of Radiology, Main Building, 7th Floor, 132 South 10th Street, Philadelphia, PA 19107, United States. Electronic address:
    Background: Clostridium septicum (C. septicum) aortitis is a rare but highly fatal infection that has a strong association with occult malignancy. Aneurysmal transformation of C. Read More

    Iatrogenic non-clostridial gas gangrene - a case report.
    Med Leg J 2016 Mar 16;84(1):49-51. Epub 2015 Dec 16.
    Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.
    Skin and soft tissue infections of the lower limbs are quite common and can at times progress rapidly to become both limb and life-threatening infections. Muscular infections usually occur in areas of the body that have been compromised or injured by a foreign body, trauma, ischaemia, injection of illicit drugs, malignancy or surgery. Gas gangrene is one such limb-threatening infection. Read More

    Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
    Toxins (Basel) 2015 Dec 3;7(12):5268-75. Epub 2015 Dec 3.
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
    Clostridium perfringens alpha-toxin is a key mediator of gas gangrene, which is a life-threatening infection that manifests as fever, pain, edema, myonecrosis, and gas production. Alpha-toxin possesses phospholipase C and sphingomyelinase activities. The toxin is composed of an N-terminal domain (1-250 aa, N-domain), which is the catalytic site, and a C-terminal domain (251-370 aa, C-domain), which is the membrane-binding site. Read More

    [Toxins of Clostridium perfringens as a natural and bioterroristic threats].
    Pol Merkur Lekarski 2015 Sep;39(231):149-52
    Military Institute of Medicine in Warsaw, Department of Internal Medicine, Pneumonology and Allergology, Central Clinical Hospital of Ministry of National Defence.
    Clostridium perfringens is absolutely anaerobic rod-shaped, sporeforming bacterium. The morbidity is connected with producing toxins. Depending on the type of toxin produced Clostridium perfringens can be divided into five serotypes:A-E. Read More

    Clinical Features of Non-clostridial Gas Gangrene and Risk Factors for In-hospital Mortality.
    Tokai J Exp Clin Med 2015 Sep 20;40(3):124-9. Epub 2015 Sep 20.
    Department of Emergency and Critical Care Medicine, Tokai University of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
    Objective: To examine the clinical features of patients with non-clostridial gas gangrene (NCGG) at our hospital and identify risk factors for in-hospital mortality.

    Methods: This study included 24 patients with NCGG who were hospitalized in our medical facility from April 2005 to March 2015. The clinical features of NCGG were reviewed, and the characteristics of 6 patients who died in hospital and 18 who survived were compared to investigate risk factors. Read More

    Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene.
    J Huazhong Univ Sci Technolog Med Sci 2015 Aug 31;35(4):563-8. Epub 2015 Jul 31.
    Department of Orthopaedic Surgery, Institute for Orthopaedic Research and Education, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China,
    Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputation. The aim of the present study was to use vacuum sealing drainage (VSD) with continuous irrigation of potassium permanganate to manage infective wounds of gas gangrene and observe its clinical efficacy. Read More

    Clostridium Sacroiliitis (Gas Gangrene) Following Sacroiliac Joint Injection--Case Report and Review of the Literature.
    Pain Physician 2015 Jul-Aug;18(4):E629-32
    Department of Anesthesiology, Henry Ford Hospital, Detroit, MI.
    An 80-year-old woman presented with chronic lumbosacral pain since her laminectomy and instrumentation 10 years ago. Examination was consistent with left sacroiliitis, and the patient underwent an elective left sacroiliac joint injection. Two days following her procedure she fell and landed on her left hip and on the next day, she presented to the emergency room with acutely worsening left gluteal pain. Read More

    A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus).
    J Vet Med Sci 2016 Jan 9;77(12):1673-6. Epub 2015 Jul 9.
    Pathological Analysis Center, Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan.
    The common marmoset is widely used in neuroscience and regenerative medicine research. However, information concerning common marmoset disorders, particularly infectious diseases, is scarce. Here, we report a case of a female common marmoset that died suddenly due to gas gangrene. Read More

    Fatal Clostridium perfringens septicemia suggested by postmortem computed tomography: A medico-legal autopsy case report.
    Forensic Sci Int 2015 Aug 21;253:e4-9. Epub 2015 May 21.
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba City, Chiba Prefecture 260-8670, Japan. Electronic address:
    We report a fatal case of suspected Clostridium (Cl.) perfringens septicemia in a previously healthy woman in her eighties. At first, she presented at the hospital complaining of upper abdominal discomfort and vomiting, and was discharged the next day after ruling out any fatal conditions. Read More

    Lipoproteins from Clostridium perfringens and their protective efficacy in mouse model.
    Infect Genet Evol 2015 Aug 28;34:434-43. Epub 2015 May 28.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior 474002, India.
    Clostridium perfringens is an obligately anaerobic rod-shaped bacterium and etiological agent for several diseases in humans and animals. The pathogen has been listed as Validated Biological Agent and warrants development of medical countermeasures. The homologs of some of the lipoproteins identified from various fractions of C. Read More

    Perfringolysin O: The Underrated Clostridium perfringens Toxin?
    Toxins (Basel) 2015 May 14;7(5):1702-21. Epub 2015 May 14.
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
    The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as θ toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Read More

    In vitro cytotoxicity induced by Clostridium perfringens isolate carrying a chromosomal cpe gene is exclusively dependent on sporulation and enterotoxin production.
    Microb Pathog 2015 Aug 23;85:1-10. Epub 2015 Apr 23.
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ourai Kita, Izumisano, Osaka 5988531, Japan.
    Clostridium perfringens type A is a common source of food poisoning (FP) and non-food-borne (NFB) gastrointestinal diseases in humans. In the intestinal tract, the vegetative cells sporulate and produce a major pathogenic factor, C. perfringens enterotoxin (CPE). Read More

    Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.
    PLoS One 2015 24;10(4):e0120497. Epub 2015 Apr 24.
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho 180, Tokushima, 770-8514, Japan.
    Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex. Alpha-toxin possesses phospholipase C (PLC) hydrolytic activity that contributes to signal transduction in the pathogenesis of gas gangrene. Little is known about the relationship between lipid metabolism and TrkA activation by alpha-toxin. Read More

    Vertebral osteomyelitis and epidural abscess caused by gas gangrene presenting with complete paraplegia: a case report.
    J Med Case Rep 2015 Apr 11;9:81. Epub 2015 Apr 11.
    Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.
    Introduction: Gas gangrene is most often caused by Clostridium perfringens infection. Gas gangrene is a medical emergency that develops suddenly. The mortality rate is higher with trunk involvement than with involvement of the extremities, which carries a better prognosis. Read More

    Multi-organ failure secondary to a Clostridium perfringens gaseous liver abscess following a self-limited episode of acute gastroenteritis.
    Am J Case Rep 2015 Mar 25;16:182-6. Epub 2015 Mar 25.
    Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA.
    Background: Clostridium perfringens is an unusual pathogen responsible for the development of a gas-forming pyogenic liver abscess. Progression to septicemia with this infection has amplified case fatality rates.

    Case Report: We report a case of an 81-year-old lady with pyogenic liver abscess with gas formation that was preceded by an acute gastroenteritis. Read More

    Animal models to study the pathogenesis of human and animal Clostridium perfringens infections.
    Vet Microbiol 2015 Aug 25;179(1-2):23-33. Epub 2015 Feb 25.
    Department of Microbiology, Monash University, Clayton, Victoria, Australia; Poultry Cooperative Research Centre, Armidale, New South Wales, Australia.
    The most common animal models used to study Clostridium perfringens infections in humans and animals are reviewed here. The classical C. perfringens-mediated histotoxic disease of humans is clostridial myonecrosis or gas gangrene and the use of a mouse myonecrosis model coupled with genetic studies has contributed greatly to our understanding of disease pathogenesis. Read More

    Epidemiological and pathobiological profiles of Clostridium perfringens infections: review of consecutive series of 33 cases over a 13-year period.
    Int J Clin Exp Pathol 2015 1;8(1):569-77. Epub 2015 Jan 1.
    Department of Gastroenterology, Saitama Medical Center, Jichi Medical University Japan.
    Background: Although Clostridium perfringens (C. perfringens) is well known as the causative agent of several forms of enteric disease, precise epidemiological and pathobiological aspects are still unknown.

    Methods: We retrospectively reviewed the culture results of samples collected in our hospital from 2001 through 2013. Read More

    [A case of freeze-dried gas gangrene antitoxin for the treatment of Clostridium perfringens sepsis].
    Nihon Shokakibyo Gakkai Zasshi 2015 Feb;112(2):332-8
    Department of Gastroenterology, Japanese Red Cross Kyoto Daiichi Hospital.
    A 66-year-old man was admitted to our hospital with high fever. We diagnosed a gas-containing liver abscess and performed percutaneous abscess drainage. However, 15 hours after admission, he developed massive intravascular hemolysis and acidosis. Read More

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