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    1240 results match your criteria Clostridial Gas Gangrene

    1 OF 25

    Uterine Clostridium perfringens infection related to gynecologic malignancy.
    Gynecol Oncol Rep 2017 Nov 21;22:55-57. Epub 2017 Sep 21.
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, United States.
    Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the Clostridium species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality. Read More

    Rare postoperative complication: Clostridium perfringens septic shock following elective abdominal surgery.
    BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.
    Department of General Surgery, Bedford Hospital NHS Trust, Bedford, UK.
    Postoperative infections are one of the most common complications in general surgery, and while rates have reduced with the routine administration of perioperative antibiotics, around 5% of patients undergoing a surgical procedure will develop an infective complication.(1) The Gram-positive, obligate anaerobe, Clostridium perfringens, is a well-known pathogen that forms part of both the environmental and gastrointestinal flora.(2) While more commonly associated with food poisoning, anaerobic cellulitis and traumatic gas gangrene, rare cases of spontaneous non-traumatic gas gangrene of abdominal viscera have also been recorded. Read More

    Design, Synthesis and Collagenase Inhibitory Activity of Some Novel Phenylglycine Derivatives as Metalloproteinase inhibitors.
    Int J Biol Macromol 2017 Oct 6. Epub 2017 Oct 6.
    Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India. Electronic address:
    Metalloproteases are a class of proteases having metal ion(s) at their catalytic sites. Bacterial collagenases are involved in human gas gangrene, periodontal diseases, food etc. The Clostridium collagenase occurs in two isoforms COL_G and Col_H. Read More

    Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat.
    Cureus 2017 Jul 13;9(7):e1469. Epub 2017 Jul 13.
    Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
    Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentation to be reported in literature. Read More

    Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A.
    PLoS One 2017 21;12(9):e0185215. Epub 2017 Sep 21.
    Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing, China.
    NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. Read More

    Spontaneous C. septicum gas gangrene: A literature review.
    Anaerobe 2017 Aug 2;48:165-171. Epub 2017 Aug 2.
    Boise VA Medical Center, Boise, ID 83702, USA. Electronic address:
    As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. Read More

    Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland.
    Pol J Microbiol 2017 Jan;65(4):399-406
    Department of Infection Epidemiology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
    The objective of the study was to perform a comparative analysis of phenotypic and genetic similarity, determination of resistance profiles, detection of toxin-encoding genes and molecular typing of Clostridium perfringens isolates originating from patients with gas gangrene. The study encompassed three patients with a clinical and microbiological diagnosis of gas gangrene who were hospitalized in one of the hospitals of the Kujawsko-Pomorskie province in the same period of time between 8(th) April 2015 and 20(th) April 2015. The three C. Read More

    Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities.
    Curr Microbiol 2017 Nov 21;74(11):1278-1286. Epub 2017 Jul 21.
    Haffkine Biopharmaceutical Corporation Limited, Pune, India.
    Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities. Read More

    A rapid qualitative assay for detection of Clostridium perfringens in canned food products.
    Acta Biochim Pol 2017 9;64(2):207-213. Epub 2017 Jun 9.
    Department of Biotechnology, P D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa-388421, India.
    Clostridium perfringens (MTCC 1349) is a Gram-positive, anaerobic, endospore forming, and rod-shaped bacterium. This bacterium produces a variety of toxins under strict anaerobic environment. C. Read More

    Complete genome sequence of Clostridium perfringens CBA7123 isolated from a faecal sample from Korea.
    Gut Pathog 2017 2;9:32. Epub 2017 Jun 2.
    Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755 Republic of Korea.
    Background: Clostridium perfringens is an opportunistic human pathogen that causes necrotic enteritis, mild diarrhea, clostridial myonecrosis or gas gangrene, sepsis, etc. In this study, we aim to determine the pathogenesis of this bacterium at the genomic level. The genome of strain CBA7123 was sequenced, and a comparative genomic analysis between strain CBA7123 and four other related C. Read More

    A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens α-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.
    Probiotics Antimicrob Proteins 2017 Apr 11. Epub 2017 Apr 11.
    Department of Anaerobic Bacterial Vaccine Research and Production, Kerman Branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran.
    The alpha-toxin is one of the virulence factors of Clostridium perfringens for gas gangrene in humans and animals or necrotic enteritis in poultry. The C-terminal domain of this toxin ( cpa 247-370 ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid. This surface-expressing plasmid was electroporated into Lactobacillus casei ATCC 393, generating the recombinant L. Read More

    Identification, Isolation, and Phylogenetic Analysis of Clostridium perfringens Type A and Type C from Wild Boar ( Sus scrofa ) in the People's Republic of China.
    J Wildl Dis 2017 Jul 22;53(3):642-648. Epub 2017 Mar 22.
    1 National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China 100101.
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). Read More

    A fatal Clostridium perfringens infection with hemolysis after chemotherapy in an adolescent.
    Arch Argent Pediatr 2017 04;115(2):e92-e95
    Department of Pediatrics, Pediatric Intensive Care Unit, Faculty of Medicine, Hacettepe University.
    Gas gangrene, clostridial myonecrosis, is one of the most serious infectious diseases, characterized by rapidly progressive destruction of deep soft tissues and production of gas within the tissues. We presented a case of fatal spontaneous gas gangrene due to Clostridium perfringens in a patient with acute lymphoblastic leukemia during remission induction chemotherapy phase. Read More

    [Necrotizing fasciitis of the upper and lower extremities].
    Chirurg 2017 Apr;88(4):353-366
    Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie-Zentrum, operatives Referenzzentrum für Gliedmaßentumoren, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.
    Necrotizing fasciitis is a potentially fatal soft tissue infection that may affect the upper and lower extremities, scrotum, perineum and abdominal wall. Typically, the infection demonstrates rapid spreading along the fascial planes leading to sepsis with mortality rates of 15-46%. Without adequate treatment, the mortality rate increases to close to 100%. Read More

    Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.
    Toxicon 2017 May 1;130:79-86. Epub 2017 Mar 1.
    Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, Jilin Province, China. Electronic address:
    Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered a potential bioterrorism threat. To date, there is still no human effective therapeutic drug against alpha-toxin. Read More

    Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model.
    Folia Microbiol (Praha) 2017 Jul 17;62(4):343-353. Epub 2017 Feb 17.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior, 474002, India.
    Clostridium perfringens is a Validated Biological Agent and a pathogen of medical, veterinary, and military significance. Gas gangrene is the most destructive of all the clostridial diseases and is caused by C. perfringens type A strains wherein the infection spreads quickly (several inches per hour) with production of gas. Read More

    Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis.
    Vet Res 2017 Feb 16;48(1). Epub 2017 Feb 16.
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.
    Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small intestinal haemorrhage, necrosis and mucosal neutrophil infiltration. The common assumption that, when causing intestinal disease, C. Read More

    Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.
    Chem Phys Lipids 2017 Mar 16;203:54-70. Epub 2017 Jan 16.
    Unidad de Biofísica (CSIC, UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain. Electronic address:
    Clostridium perfringens alpha-toxin (ATX) is considered as a prototype of cytotoxic bacterial phospholipases C, and is the major virulence factor in C. perfringens-induced gas gangrene. It is known that, depending on the dose, ATX causes membrane disruption and cytolysis or only limited hydrolysis of its substrates. Read More

    Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 Dec 22;9(1). Epub 2016 Dec 22.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. Read More

    Clostridium perfringens: a rare cause of spondylodiscitis case report and review of the literature.
    Br J Neurosurg 2016 Dec 14:1-3. Epub 2016 Dec 14.
    a Department of Orthopaedic , Study Conducted at the University Hamburg Eppendorf , Hamburg , Germany.
    Presented is a case of a 64-year old male with a unique and yet unreported case of a spondylodiscitis caused by Clostridium perfringens. Becoming symptomatic with massive neurological deficits. Computed tomography (CT) revealed typical signs of spondylodiscitis involving the vertebral body L5 with extensive vacuum phenomenon. Read More

    Fulminant Clostridium perfringens Sepsis in Kidney Transplant: A Case Report.
    Transplant Proc 2016 Nov;48(9):3112-3114
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
    Background: Infections, particularly urinary tract infections, and cardiovascular accidents are the main causes of morbidity and mortality during the 1st year after kidney transplantation (KT). Bacteria and viruses, such as Escherichia coli, Enteroccoci, and Polyoma BK virus are common in the 1st 6 months, so they are controlled routinely. On the other hand, Clostridium perfringens infection is a rare life-threatening condition, associated with a high mortality rate especially in the transplant population, that is not controlled routinely. Read More

    Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.
    Toxins (Basel) 2016 Nov 21;8(11). Epub 2016 Nov 21.
    Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas, Pelotas CEP 96160-000, Rio Grande do Sul, Brazil.
    Clostridium perfringens is a spore-forming, commensal, ubiquitous bacterium that is present in the gastrointestinal tract of healthy humans and animals. This bacterium produces up to 18 toxins. The species is classified into five toxinotypes (A-E) according to the toxins that the bacterium produces: alpha, beta, epsilon, or iota. Read More

    Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets.
    Toxins (Basel) 2016 Nov 19;8(11). Epub 2016 Nov 19.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Room 420, Bridgeside Point II Building, 450 Technology Drive, Pittsburgh, PA 15219, USA.
    Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. Read More

    CLOSTRIDIAL PARAPROCTITIS WITH GAS GANGRENE OF FRONT-LATERAL ABDOMINAL WALLS AND NECROTIC FASCIO-MYOSITIS (CASE REPORT).
    Georgian Med News 2016 Sep(258):73-76
    Tbilisi State Medical University; The First University Clinic, Georgia.
    Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. Read More

    Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils.
    Biol Pharm Bull 2016 ;39(10):1694-1700
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
    Clostridium perfringens type A, a Gram-positive, anaerobic bacterium, causes gas gangrene. Recently, we reported that C. perfringens α-toxin blocked neutrophil differentiation in an enzyme activity-dependent manner to impair host innate immunity, which should be crucial for the pathogenesis of C. Read More

    Clostridium septicum: An Unusual Link to a Lower Gastrointestinal Bleed.
    Case Rep Gastroenterol 2016 May-Aug;10(2):489-493. Epub 2016 Sep 12.
    Gastroenterology Division, Department of Medicine, SUNY Upstate Medical University, Syracuse, N.Y., USA.
    Clostridium septicum is a highly virulent pathogen which is associated with colorectal malignancy, hematological malignancy, immunosuppression, diabetes mellitus and cyclical neutropenia. Presentation may include disseminated clostridial infection in the form of septicemia, gas gangrene, and mycotic aortic aneurysms. We report the case of a 62-year-old female presenting with necrotizing fasciitis of her left thigh and subsequently developing rectal bleeding. Read More

    Fatal Clostridium perfringens Septicemia After Colonoscopic Polypectomy, Without Bowel Perforation.
    J Forensic Sci 2016 Nov 22;61(6):1689-1692. Epub 2016 Sep 22.
    Section of Legal Medicine, University of Perugia, via T. di Joannuccio snc, Terni, 05100, Italy.
    Since its introduction, colonoscopy has played an important role as a diagnostic, therapeutic, and screening tool. In general, colonoscopy is regarded as a safe procedure, but complications may occur. The most dreaded of these complications is colonic perforation. Read More

    The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme.
    PLoS One 2016 16;11(9):e0162981. Epub 2016 Sep 16.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
    The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capable of utilizing both human hemoglobin and ferric chloride, but not human holo-transferrin, as an iron source for in vitro growth. Read More

    Clostridial Gas Gangrene of the Abdominal Wall After Laparoscopic Cholecystectomy: A Case Report and Review.
    Surg Laparosc Endosc Percutan Tech 2016 Aug;26(4):278-81
    Department of Surgery, MC Slotervaart, Amsterdam, The Netherlands.
    Clostridial gas gangrene is a rare, yet severe, complication after laparoscopic cholecystectomy. We present a case report of a 48-year-old man with obesity, coronary artery disease, and diabetes, who developed clostridial gas gangrene of the abdominal wall after an uncomplicated laparoscopic cholecystectomy. Although the diagnosis was missed initially, successful radical surgical debridement was performed and the patient survived. Read More

    A case of acute onset postoperative gas gangrene caused by Clostridium perfringens.
    BMC Res Notes 2016 Aug 3;9:385. Epub 2016 Aug 3.
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
    Background: Gas gangrene is a necrotic infection of soft tissue associated with high mortality rates. We report a case of postoperative gas gangrene with very acute onset and rapid progression of symptoms. To our knowledge, this case is the most acute onset of postoperative gas gangrene ever reported. Read More

    Regulation of Toxin Production in Clostridium perfringens.
    Toxins (Basel) 2016 Jul 5;8(7). Epub 2016 Jul 5.
    Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.
    The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. Read More

    Putative function of hypothetical proteins expressed by Clostridium perfringens type A strains and their protective efficacy in mouse model.
    Infect Genet Evol 2016 Oct 21;44:147-56. Epub 2016 Jun 21.
    Biotechnology Division, Defence Research and Development Establishment, Gwalior 474002, India.
    The whole genome sequencing and annotation of Clostridium perfringens strains revealed several genes coding for proteins of unknown function with no significant similarities to genes in other organisms. Our previous studies clearly demonstrated that hypothetical proteins CPF_2500, CPF_1441, CPF_0876, CPF_0093, CPF_2002, CPF_2314, CPF_1179, CPF_1132, CPF_2853, CPF_0552, CPF_2032, CPF_0438, CPF_1440, CPF_2918, CPF_0656, and CPF_2364 are genuine proteins of C. perfringens expressed in high abundance. Read More

    Uterine Perforation with Intra-Abdominal Clostridium perfringens Gas Gangrene: A Rare and Fatal Infection.
    J Gynecol Surg 2016 Jun;32(3):182-184
    Richmond University Medical Center , Staten Island, NY.
    Background:Clostridium perfringens gas gangrene is an extremely rare and fatal infection. Necrosis of the myometrium is rarely seen and has only been recorded in 18 cases to date. Of these 18 reported cases, only 5 have occurred in nonpregnant women. Read More

    Analysis of the virulence-associated RevSR two-component signal transduction system of Clostridium perfringens.
    Int J Med Microbiol 2016 Sep 20;306(6):429-42. Epub 2016 May 20.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address:
    Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that causes human gas gangrene (clostridial myonecrosis) and food poisoning. Early studies showed that virulence was regulated by the VirSR two-component signal transduction system. However, our identification of the RevR orphan response regulator indicated that more than one system was involved in controlling virulence. Read More

    Massive gas gangrene secondary to occult colon carcinoma.
    Radiol Case Rep 2016 Jun 5;11(2):67-9. Epub 2016 Mar 5.
    Department of Radiology, Duke University Medical Center, DUMC Box 3808, Durham, NC 27710, USA.
    Gas gangrene is a rare but often fatal soft-tissue infection. Because it is uncommon and the classic symptom of crepitus does not appear until the infection is advanced, prompt diagnosis requires a high index of suspicion. We present a case report of a middle-aged man who presented with acute onset lower-extremity pain that was initially thought to be due to deep vein thrombosis. Read More

    RNA-seq analysis of virR and revR mutants of Clostridium perfringens.
    BMC Genomics 2016 May 23;17:391. Epub 2016 May 23.
    Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, 3800, Australia.
    Background: Clostridium perfringens causes toxin-mediated diseases, including gas gangrene (clostridial myonecrosis) and food poisoning in humans. The production of the toxins implicated in gas gangrene, α-toxin and perfringolysin O, is regulated by the VirSR two-component regulatory system. In addition, RevR, an orphan response regulator, has been shown to affect virulence in the mouse myonecrosis model. Read More

    Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
    Toxins (Basel) 2016 Apr 13;8(4):109. Epub 2016 Apr 13.
    Institute for Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
    Lethal Toxin from Clostridium sordellii (TcsL) and Toxin B from Clostridium difficile (TcdB) belong to the family of the "Large clostridial glycosylating toxins." These toxins mono-O-glucosylate low molecular weight GTPases of the Rho and Ras families by exploiting UDP-glucose as a hexose donor. TcsL is casually involved in the toxic shock syndrome and the gas gangrene. Read More

    Clostridium Perfringens Infection in a Febrile Patient with Severe Hemolytic Anemia.
    Am J Case Rep 2016 Apr 6;17:219-23. Epub 2016 Apr 6.
    Department of Emergency and Acute Intensive Care Medicine, Aichi Medical University, Nagakute, Japan.
    Background: Clostridium perfringens (C. perfringens) can cause various infections, including gas gangrene, crepitant cellulitis, and fasciitis. While C. Read More

    Fatal Clostridium perfringens sepsis due to emphysematous gastritis and literature review.
    Anaerobe 2016 Aug 30;40:31-4. Epub 2016 Mar 30.
    Department of Clinical Microbiology, University of Szeged, Szeged, Hungary.
    A 76-year-old female patient was admitted to the Level I Emergency Department of University of Szeged with severe abdominal pain and vomiting. The clinical assessment with laboratory tests and radiological investigations confirmed severe sepsis associated with intravascular hemolysis and multiorgan failure and acute pancreatitis. On the abdominal CT, besides of other abnormalities, the presence of gas bubbles in the stomach, small intestines and liver were seen. Read More

    Oral immunization of mice against Clostridium perfringens epsilon toxin with a Lactobacillus casei vector vaccine expressing epsilon toxoid.
    Infect Genet Evol 2016 Jun 21;40:282-7. Epub 2016 Mar 21.
    Department of Immunology, Medical School of Kerman University, Kerman, Iran.
    Clostridium perfringens type D infects ruminants and causes the enterotoxemia disease by ε-toxin. A mutated ε-toxin gene lacking toxicity was designed, synthesized, and cloned into the pT1NX vector and electroporated into Lactobacillus casei competent cells to yield LC-pT1NX-ε recombinant strain. BALB/c mice, immunized orally with this strain, highly induced mucosal, humoral, and cell-mediated immune responses and developed a protection against 200 MLD/ml of the activated ε-toxin. Read More

    Optimization of the Production of Inactivated Clostridium novyi Type B Vaccine Using Computational Intelligence Techniques.
    Appl Biochem Biotechnol 2016 Jul 22;179(5):895-909. Epub 2016 Mar 22.
    Programa de Pós-Graduação em Engenharia Química, UFSCar, Federal University of Sao Carlos, Rodovia Washington Luís, km 235, 13565-905, Monjolinho - São Carlos, São Paulo, Brazil.
    Clostridium novyi causes necrotic hepatitis in sheep and cattle, as well as gas gangrene. The microorganism is strictly anaerobic, fastidious, and difficult to cultivate in industrial scale. C. Read More

    Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis.
    Case Rep Infect Dis 2015 17;2015:694247. Epub 2015 Dec 17.
    Department of Internal Hospital Medicine, H. Lee Moffitt Cancer Center, Tampa, FL 33612-9416, USA; USF College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612-9416, USA.
    The Clostridia species are responsible for some of the deadliest diseases including gas gangrene, tetanus, and botulism. Clostridium septicum is a rare subgroup known to cause atraumatic myonecrosis and is associated with colonic malignancy or immunosuppression. It is a Gram-positive, anaerobic, spore-forming bacillus found in the gastrointestinal tract and can lead to direct, spontaneous infections of the bowel and peritoneal cavity. Read More

    Clostridium septicum aortitis and colon carcinoma.
    J Cardiovasc Comput Tomogr 2016 May-Jun;10(3):258-60. Epub 2016 Jan 8.
    Thomas Jefferson University Hospital, Department of Radiology, Main Building, 7th Floor, 132 South 10th Street, Philadelphia, PA 19107, United States. Electronic address:
    Background: Clostridium septicum (C. septicum) aortitis is a rare but highly fatal infection that has a strong association with occult malignancy. Aneurysmal transformation of C. Read More

    Iatrogenic non-clostridial gas gangrene - a case report.
    Med Leg J 2016 Mar 16;84(1):49-51. Epub 2015 Dec 16.
    Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.
    Skin and soft tissue infections of the lower limbs are quite common and can at times progress rapidly to become both limb and life-threatening infections. Muscular infections usually occur in areas of the body that have been compromised or injured by a foreign body, trauma, ischaemia, injection of illicit drugs, malignancy or surgery. Gas gangrene is one such limb-threatening infection. Read More

    Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin.
    Toxins (Basel) 2015 Dec 3;7(12):5268-75. Epub 2015 Dec 3.
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
    Clostridium perfringens alpha-toxin is a key mediator of gas gangrene, which is a life-threatening infection that manifests as fever, pain, edema, myonecrosis, and gas production. Alpha-toxin possesses phospholipase C and sphingomyelinase activities. The toxin is composed of an N-terminal domain (1-250 aa, N-domain), which is the catalytic site, and a C-terminal domain (251-370 aa, C-domain), which is the membrane-binding site. Read More

    [Toxins of Clostridium perfringens as a natural and bioterroristic threats].
    Pol Merkur Lekarski 2015 Sep;39(231):149-52
    Military Institute of Medicine in Warsaw, Department of Internal Medicine, Pneumonology and Allergology, Central Clinical Hospital of Ministry of National Defence.
    Clostridium perfringens is absolutely anaerobic rod-shaped, sporeforming bacterium. The morbidity is connected with producing toxins. Depending on the type of toxin produced Clostridium perfringens can be divided into five serotypes:A-E. Read More

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