1,316 results match your criteria Clostridial Gas Gangrene


A rare cause of pneumoperitoneum due to clostridium perfringens in a cirrhotic patient.

Acta Chir Belg 2020 Jul 1:1-3. Epub 2020 Jul 1.

Department of General, Visceral and Transplantation Surgery, University Hospital, Tübingen, Germany.

Abdominal gas gangrene caused by Clostridium perfringens is a rare differential diagnosis to pneumoperitoneum caused by bowel perforation. There are only a handful of case reports on this topic. We present the case of a 58 year old cirrhotic patient who represented to our ER after complicated surgery for retroperitoneal liposarcoma. Read More

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http://dx.doi.org/10.1080/00015458.2020.1785218DOI Listing

The Agr-Like Quorum-Sensing System Is Important for Type A Strain ATCC 3624 To Cause Gas Gangrene in a Mouse Model.

mSphere 2020 Jun 17;5(3). Epub 2020 Jun 17.

California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, Davis, San Bernardino, California, USA

type A is involved in gas gangrene in humans and animals. Following a traumatic injury, rapid bacterial proliferation and exotoxin production result in severe myonecrosis. alpha toxin (CPA) and perfringolysin (PFO) are the main virulence factors responsible for the disease. Read More

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http://dx.doi.org/10.1128/mSphere.00500-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300355PMC

Non-traumatic gas gangrene due to Clostridium sporogenes.

Lancet Infect Dis 2020 Jun;20(6):754

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(20)30024-4DOI Listing

A case report of iatrogenic gas gangrene post colonoscopy successfully treated with conservative management- is surgery always necessary?

BMC Gastroenterol 2020 May 27;20(1):163. Epub 2020 May 27.

The Mater Hospital, Townsville, Australia.

Background: Colonoscopy is a routine procedure in diagnosis and treatment of colonic disease. While generally regarded as a safe procedure, potentially fatal complications can occur. Gas gangrene is one such complication, with very high mortality. Read More

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http://dx.doi.org/10.1186/s12876-020-01314-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254699PMC

in Gas Gangrene: Still a Smoked Gun!

J Transl Int Med 2020 03 9;8(1):54-56. Epub 2020 May 9.

Intensive care Departement, Brugmann University Hospital, Brussels, Belgium.

Gas gangrene (GG) remains a life-threatening and deadly disease. Early recognition together with daily surgical debridement remains the mainstay of therapy. We sought to describe a fatal case of necrotizing soft tissue infection, which was a gas gagrene in this case. Read More

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http://dx.doi.org/10.2478/jtim-2020-0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227166PMC

Distant myonecrosis by atraumatic infection in a patient with metastatic breast cancer.

IDCases 2020 5;20:e00784. Epub 2020 May 5.

Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.

is an anaerobic, gram-positive bacillus known to cause myonecrosis, also known as gas gangrene, a life-threatening necrotizing soft tissue infection. Though it accounts for just 1 % of all infections attributable to spp., is a highly virulent and aggressive pathogen. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218154PMC

Amentoflavone Attenuates Gas Gangrene by Targeting Alpha-Toxin and Perfringolysin O.

Front Pharmacol 2020 28;11:179. Epub 2020 Feb 28.

Cadre's Ward, The First Hospital of Jilin University, Jilin University, Changchun, China.

() type A strains are the main cause of gas gangrene in humans and animals. Treatment of this lethal disease is limited, and the prognosis is not good. Alpha-toxin (CPA) and perfringolysin O (PFO) secreted by play irreplaceable roles in cytotoxicity to host cells, persistence in host tissues, and lethality of gas gangrene pathology. Read More

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http://dx.doi.org/10.3389/fphar.2020.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059699PMC
February 2020

Antibiotic resistance, genome analysis and further safe traits of Clostridium perfringens ICVB082; a strain capable of producing an inhibitory compound directed only against a closely related pathogenic strain.

Anaerobe 2020 Apr 15;62:102177. Epub 2020 Feb 15.

Université Lille, INRA, ISA, Université d'Artois, Université Littoral Côte d'Opale, EA 7394-ICV Institut Charles Viollette, F-59000, Lille, France. Electronic address:

Eleven strains of clostridia were isolated from chickens suffering from necrotic enteritis (NE) disease, and were identified by 16S rDNA sequencing as C. perfringens (Clin1, ICVB079, ICVB080, ICVB081, ICVB082, ICVB083, ICVB085, ICVB088, ICVB089, ICVB090), C. sporogenes (ICVB086) and C. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2020.102177DOI Listing

Gas gangrene in mammals: a review.

J Vet Diagn Invest 2020 Mar 21;32(2):175-183. Epub 2020 Feb 21.

Veterinary School, Federal University of Minas Gerais, Brazil (Oliveira Junior, Silva, Lobato).

Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. type A, type A, and are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Read More

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http://dx.doi.org/10.1177/1040638720905830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081496PMC

Paeniclostridium (Clostridium) sordellii-associated enterocolitis in 7 horses.

J Vet Diagn Invest 2020 Mar 13;32(2):239-245. Epub 2020 Feb 13.

California Animal Health and Food Safety Laboratory System, University of California-Davis, San Bernardino (Nyaoke, Navarro, Fresneda, Moore, Uzal) and Davis (Diab) branches, CA.

Enteric disease in horses may be caused by a variety of microorganisms, including several clostridial species. (previously ) has been frequently associated with gas gangrene in humans and several animal species, including horses. However, its role in enteric diseases of animals has not been fully determined. Read More

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http://dx.doi.org/10.1177/1040638720903738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081492PMC

Sialidases From and Their Inhibitors.

Authors:
Yan-Hua Wang

Front Cell Infect Microbiol 2019 10;9:462. Epub 2020 Jan 10.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

is an important human and animal pathogen that is the primary causative agent of necrotizing enteritis and enterotoxemia in many types of animals; it causes traumatic gas gangrene in humans and animals and is associated with cases of food poisoning in humans. produces a variety of toxins as well as many enzymes, including three sialidases, NanH, NanI, and NanJ. Sialidases could be important virulence factors that promote the pathogenesis of . Read More

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http://dx.doi.org/10.3389/fcimb.2019.00462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966327PMC
January 2020

Generation of recombinant baculovirus expressing atoxic C-terminal CPA toxin of Clostridium perfringens and production of specific antibodies.

BMC Biotechnol 2020 01 28;20(1). Epub 2020 Jan 28.

Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini 1, 06126, Perugia, Italy.

Background: Clostridium perfringens is the causative agent of several diseases and enteric infections in animals and humans. The virulence of C. perfringens is largely attributable to the production of numerous toxins; of these, the alpha toxin (CPA) plays a crucial role in histotoxic infections (gas gangrene). Read More

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http://dx.doi.org/10.1186/s12896-019-0597-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986089PMC
January 2020

The EngCP endo α-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene infections.

Int J Med Microbiol 2020 Feb 17;310(2):151398. Epub 2020 Jan 17.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton 3800, Australia. Electronic address:

Clostridium perfringens is the causative agent of human clostridial myonecrosis; the major toxins involved in this disease are α-toxin and perfringolysin O. The RevSR two-component regulatory system has been shown to be involved in regulating virulence in a mouse myonecrosis model. Previous microarray and RNAseq analysis of a revR mutant implied that factors other than the major toxins may play a role in virulence. Read More

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http://dx.doi.org/10.1016/j.ijmm.2020.151398DOI Listing
February 2020

Evidence for Infections by the Same Strain of Beta 2-toxigenic Type A Acquired in One Hospital Ward.

Pol J Microbiol 2019 Sep 3;68(3):323-329. Epub 2019 Sep 3.

Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College , Krakow , Poland.

This study conducts a comparative phenotypic and genetic analysis of strains isolated from two patients hospitalized at the same time in 2017 in the surgical ward of the Provincial Specialist Hospital in Włocławek (Kujawsko-Pomorskie Province) who developed necrotizing soft tissue infections (NSTI). To explain the recurring cases of this infection, a comparative analysis was performed for these strains and the ones originating from infections recorded at the same hospital in three patients with gas gangrene in 2015. The two isolates studied in 2017 (8554/M/17 from patient No. Read More

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http://dx.doi.org/10.33073/pjm-2019-035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256698PMC
September 2019

Spontaneous Non-Traumatic Clostridium perfringens Sepsis.

Authors:
Toru Hifumi

Jpn J Infect Dis 2020 May 25;73(3):177-180. Epub 2019 Dec 25.

Department of Emergency and Critical Care Medicine, St. Luke's International Hospital.

Clostridium species are gram-positive, spore-forming, anaerobic rods normally found in the soil and gastrointestinal tract of humans and animals. Spontaneous sepsis due to C. perfringens is not caused by injury, which sets it apart from the classical gas gangrene that typically follows trauma. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2019.382DOI Listing

Gas gangrene as a surgical emergency - own experience.

Pol Przegl Chir 2019 Oct;91(6):1-5

II Klinika Chirurgii Ogólnej i Gastroenterologicznej, Uniwersytet Medyczny w Białymstoku.

In this paper the authors would like to present a correct procedure in both surgical and hyperbaric treatment of patients with gas gangrene admitted to a surgical department during ER. Gas gangrene is not very common these days, but when it comes to dealing with gangrenous infection in the emergency it is quite likely to make errors in both diagnostic and therapeutic manners. When there is a gas gangrene in a patient at the emergency time plays crucial role and the proper application of procedures is vital for the patient's survival. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5076DOI Listing
October 2019

Clostridium septicum-infected aortic aneurysm or graft is a deadly diagnosis.

J Vasc Surg 2020 May 13;71(5):1781-1788. Epub 2019 Dec 13.

Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Background: Clostridium septicum is an anaerobic, motile, spore-forming, toxin-producing gram-positive bacillus that can lead to rapidly progressive gas gangrene due to the release of alpha toxin. Aortic aneurysm secondary to C. septicum infection is a rare condition with 60 cases reported in the literature; however, we have recently treated several patients with the condition in our large tertiary care and aortic center. Read More

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http://dx.doi.org/10.1016/j.jvs.2019.09.029DOI Listing

Immunization of rabbits with recombinant Clostridium perfringens alpha toxins CPA-C and CTB-CPA-C in a bicistronic design expression system confers strong protection against challenge.

Protein Expr Purif 2020 03 4;167:105550. Epub 2019 Dec 4.

Department of Bacterial Biologics, China Institute of Veterinary Drug Control, Beijing, China.

The Clostridium perfringens alpha toxin (CPA), encoded by the plc gene, is the causative pathogen of gas gangrene, which is a lethal infection. In this study, we used an E. coli system for the efficient production of recombinant proteins and developed a bicistronic design (BCD) expression construct consisting of two copies of the C-terminal (247-370) domain of the alpha toxin (CPA-C) in the first cistron, followed by Cholera Toxin B (CTB) linked with another two copies of CPA-C in the second cistron that is controlled by a single promoter. Read More

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http://dx.doi.org/10.1016/j.pep.2019.105550DOI Listing

The antibiotic susceptibility pattern of gas gangrene-forming spp. clinical isolates from South-Eastern Hungary.

Infect Dis (Lond) 2020 03 28;52(3):196-201. Epub 2019 Nov 28.

Institute of Clinical Microbiology, University of Szeged, Szeged, Hungary.

and other gas gangrene-forming clostridia are commensals of the human gut and vaginal microbiota, but can cause serious or even fatal infections. As there are relatively few published studies on antibiotic susceptibility of these bacteria, we decided to perform a 10-year retrospective study in a South-Eastern Hungarian clinical centre. A total of 372 gas gangrene-forming spp. Read More

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http://dx.doi.org/10.1080/23744235.2019.1696472DOI Listing

Thermophile Lytic Enzyme Fusion Proteins that Target .

Antibiotics (Basel) 2019 Nov 8;8(4). Epub 2019 Nov 8.

Animal Biosciences and Biotechnology Laboratory, United States Department of Agricultural (USDA), Agricultural Research Service, Baltimore Avenue, Beltsville, MD 10300, USA.

is a bacterial pathogen that causes necrotic enteritis in poultry and livestock, and is a source of food poisoning and gas gangrene in humans. As the agriculture industry eliminates the use of antibiotics in animal feed, alternatives to antibiotics will be needed. Bacteriophage endolysins are enzymes used by the virus to burst their bacterial host, releasing bacteriophage particles. Read More

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http://dx.doi.org/10.3390/antibiotics8040214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963370PMC
November 2019

Inflammasome Activation Induced by Perfringolysin O of and Its Involvement in the Progression of Gas Gangrene.

Front Microbiol 2019 25;10:2406. Epub 2019 Oct 25.

Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

() is Gram-positive anaerobic, spore-forming rod-shaped bacterial pathogen that is widely distributed in nature. This bacterium is known as the causative agent of a foodborne illness and of gas gangrene. While the major virulence factors are the α-toxin and perfringolysin O (PFO) produced by type A strains of , the precise mechanisms of how these toxins induce the development of gas gangrene are still not well understood. Read More

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http://dx.doi.org/10.3389/fmicb.2019.02406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823607PMC
October 2019

Clostridium perfringens Septicemia with Massive Intravascular Hemolysis.

Intern Med 2020 02 31;59(4):591. Epub 2019 Oct 31.

Department of Internal Medicine, Suwa Central Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.3793-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056373PMC
February 2020

associated gas gangrene in 8 horses, 1998-2019.

J Vet Diagn Invest 2020 Mar 4;32(2):246-251. Epub 2019 Oct 4.

Veterinary Sciences Institute of Litoral and Morphological Sciences Department, Veterinary Sciences School, National University of Litoral, Santa Fe, Argentina (Sacco).

Gas gangrene occurs in several animal species and is caused by one or more clostridial species. In horses, the disease is most often caused by type A. Although has been associated with gas gangrene in ruminants and humans, cases of the disease associated with this microorganism have not been described in horses, to our knowledge. Read More

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http://dx.doi.org/10.1177/1040638719877844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081493PMC
March 2020
1 Read

Vaccine Production to Protect Animals Against Pathogenic Clostridia.

Toxins (Basel) 2019 09 11;11(9). Epub 2019 Sep 11.

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.

is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic . Read More

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http://dx.doi.org/10.3390/toxins11090525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783934PMC
September 2019
2 Reads

Gangrenous gas necrosis of the spleen: a case report.

BMC Infect Dis 2019 Sep 5;19(1):777. Epub 2019 Sep 5.

Division of Digestive Surgery, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Genève 14, Switzerland.

Background: Splenic abscess usually arises from hematogenous spread. Causative pathogens are various and anaerobic pathogens are rarely reported.

Case Presentation: We report the case of a 50-year-old male patient who was admitted for sepsis due to gangrenous necrosis of the spleen associated with bacteremia. Read More

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http://dx.doi.org/10.1186/s12879-019-4406-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727493PMC
September 2019
2.613 Impact Factor

Granulocyte Colony-Stimulating Factor Does Not Influence α-Toxin-Induced Myonecrosis in Mice.

Toxins (Basel) 2019 08 30;11(9). Epub 2019 Aug 30.

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

type A causes gas gangrene characterized by myonecrosis and development of an effective therapy for treating affected patients is of clinical importance. It was recently reported that the expression of granulocyte colony-stimulating factor (G-CSF) is greatly up-regulated by infection. However, the role of G-CSF in -mediated myonecrosis is still unclear. Read More

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http://dx.doi.org/10.3390/toxins11090509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784116PMC
August 2019
1 Read

Type A fulminant Clostridium perfringens sepsis indicated RBC/Hb discrepancy; a case report.

BMC Infect Dis 2019 Aug 15;19(1):719. Epub 2019 Aug 15.

Department of Emergency Medicine, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 596-8686, Japan.

Background: Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and fasciitis. C. perfringens septicemia is rare, but is a known cause of hemolysis by damaging red blood cell, and often proves rapidly fatal in emergency department (ED) situations. Read More

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http://dx.doi.org/10.1186/s12879-019-4350-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694550PMC
August 2019
3 Reads

Histotoxic Clostridial Infections.

Microbiol Spectr 2018 08;6(4)

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.

The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in -mediated and -mediated myonecrosis. The major toxins involved are α-toxin, which has phospholipase C and sphingomyelinase activity, and α-toxin, a β-pore-forming toxin that belongs to the aerolysin family. Read More

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http://dx.doi.org/10.1128/microbiolspec.GPP3-0024-2018DOI Listing
August 2018
3 Reads

Inactivated recombinant Escherichia coli as a candidate vaccine against Clostridium perfringens alpha toxin in sheep.

Anaerobe 2019 Oct 9;59:163-166. Epub 2019 Jul 9.

Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, CEP 96160-000, Brazil.

Clostridium perfringens type A is the causative agent of gas gangrene and gastroenteric ("yellow lamb disease") disease in ruminants, with C. perfringens alpha toxin (CPA) being the main virulence factor in the pathogenesis of these illnesses. In the present study, we have developed recombinant Escherichia coli bacteria expressing rCPA and used it to vaccinate rabbits and sheep. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.07.002DOI Listing
October 2019
5 Reads

Frightening" Resistant Clostridial Myonecrosis: A Case Report.

Cureus 2019 Apr 24;11(4):e4539. Epub 2019 Apr 24.

Internal Medicine, Sahiwal Medical College, Sahiwal, PAK.

Clostridial myonecrosis is a diffuse necrotizing infection of deep soft tissues. It is known for its acute, rapid progression, poor prognosis, and high mortality. We report a case of traumatic clostridial myonecrosis, a 17-year-old, previously healthy female reported to our department with the complaint of pain in her left arm a week after she suffered a fall from her chair on to her left arm. Read More

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http://dx.doi.org/10.7759/cureus.4539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592470PMC
April 2019
6 Reads

Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene.

Infect Immun 2019 08 23;87(8). Epub 2019 Jul 23.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

Gas gangrene, or clostridial myonecrosis, is usually caused by and may occur spontaneously in association with diabetes mellitus, peripheral vascular disease, or some malignancies but more often after contamination of a deep surgical or traumatic lesion. If not controlled, clostridial myonecrosis results in multiorgan failure, shock, and death, but very little is known about the muscle regeneration process that follows myonecrosis when the infection is controlled. In this study, we characterized the muscle regeneration process after myonecrosis caused in a murine experimental infection with a sublethal inoculum of vegetative cells. Read More

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http://dx.doi.org/10.1128/IAI.00200-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652765PMC
August 2019
6 Reads

A deceptive case of emphysematous cholecystitis complicated with retroperitoneal gangrene and emphysematous pancreatitis: clinical and computed tomography features.

Pol J Radiol 2019 16;84:e41-e45. Epub 2019 Jan 16.

1 Department of Clinical Radiology, Medical University of Warsaw, Poland.

Purpose: Emphysematous cholecystitis (EC) is an uncommon, severe variant of acute cholecystitis caused by gas- forming bacteria - most often and . We present a deceptive case of EC associated with retroperitoneal gas gangrene and emphysematous pancreatitis.

Case Report: An 86-year-old, overweight woman was admitted to the emergency department with non-specific abdominal symptoms. Read More

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http://dx.doi.org/10.5114/pjr.2019.82858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479146PMC
January 2019
11 Reads

as a cause of gas gangrene in a trauma patient.

J Lab Physicians 2019 Jan-Mar;11(1):94-96

Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Gas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is followed by . Read More

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http://www.jlponline.org/text.asp?2019/11/1/94/254074
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http://dx.doi.org/10.4103/JLP.JLP_108_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437822PMC
April 2019
23 Reads

Hepatic gas gangrene caused by Clostridium novyi.

Anaerobe 2019 Jun 4;57:90-92. Epub 2019 Apr 4.

Department of Laboratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan. Electronic address:

We report the case of a patient with advanced gastric cancer and multiple liver metastases, who presented with bacteremia and hepatic gas gangrene caused by Clostridium novyi (C. novyi). The gas gangrene caused abscesses to form within metastatic lesions. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.03.018DOI Listing
June 2019
9 Reads

A sandwich duplex immuno PCR for rapid and sensitive identification of Clostridium perfringens alpha and enterotoxin.

Anaerobe 2019 Jun 26;57:63-74. Epub 2019 Mar 26.

Microbiology Division, Defence Food Research Laboratory, Mysore, 570011, India. Electronic address:

The prevalence and lethality associated with C. perfringens alpha (CPA) and enterotoxin (CPE) toxaemia necessitate the need for rapid and definitive detection systems to initiate management measures. In the present study, a sandwich duplex immuno-capture PCR (SD-IPCR) was developed by employing IgY antibodies against a bivalent protein r-Cpae derived from CPA and CPE for antigen capture and reporter antibodies against truncated CPA or CPE conjugated to oligomers of distinguishable size for antigen revealing and signal amplification. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.03.015DOI Listing
June 2019
4 Reads

Gas-forming gluteal abscess after intramuscular self-injections due to .

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Internal Medicine, Hospital Universitario de Mostoles, Mostoles, Spain.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22840
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http://dx.doi.org/10.1136/bcr-2018-228408DOI Listing
February 2019
43 Reads

α-toxin impairs granulocyte colony-stimulating factor receptor-mediated granulocyte production while triggering septic shock.

Commun Biol 2019 31;2:45. Epub 2019 Jan 31.

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514 Japan.

During bacterial infection, granulocyte colony-stimulating factor (G-CSF) is produced and accelerates neutrophil production from their progenitors. This process, termed granulopoiesis, strengthens host defense, but α-toxin impairs granulopoiesis via an unknown mechanism. Here, we tested whether G-CSF accounts for the α-toxin-mediated impairment of granulopoiesis. Read More

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http://dx.doi.org/10.1038/s42003-019-0280-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355902PMC
April 2020
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Sudden death due to gas gangrene caused by Clostridium septicum in goats.

BMC Vet Res 2018 Dec 18;14(1):406. Epub 2018 Dec 18.

Department of Microbiology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Turkey.

Background: Even though gas gangrene caused by Clostridium septicum in goats is mentioned in the classical textbooks, we have not managed to find any case description in the literature.

Case Presentation: Clinical signs resembling gas gangrene such as subcutaneous bloating, edema and crepitation were detected at various body parts of nine pregnant animals at the ages of 2-3 years on a hair goat farm (n = 170) located in Bingol province, Eastern Turkey. Five of these suspected animals with severe clinical symptoms died within 2 days. Read More

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http://dx.doi.org/10.1186/s12917-018-1747-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299590PMC
December 2018
10 Reads

[Host Defense against Bacterial Infection and Bacterial Toxin-induced Impairment of Innate Immunity].

Authors:
Masaya Takehara

Yakugaku Zasshi 2018 ;138(10):1249-1253

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

 Whereas granulopoiesis during Gram-negative bacterial infection is accelerated through activation of toll-like receptor 4 (TLR4), it has not been elucidated whether Gram-positive bacterial infection can stimulate granulopoiesis. Using the well-known TLR2 agonist peptidoglycan (PGN), it was shown that neutrophils in bone marrow and spleen and plasma granulocyte colony-stimulating factor were increased in mice that had received intraperitoneal administration of PGN. Incorporation of bromodeoxyuridine into bone marrow neutrophils increased in mice administered PGN, demonstrating that PGN promotes granulopoiesis. Read More

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http://dx.doi.org/10.1248/yakushi.18-00102DOI Listing
October 2018
14 Reads

Clostridium septicum Myonecrosis Secondary to an Occult Small Bowel Adenocarcinoma.

J Gastrointest Cancer 2019 Dec;50(4):1001-1004

Spectrum Health Hospital, Acute Care Surgery, 221 Michigan NE, Suite 402, Grand Rapids, MI, 49503, USA.

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http://dx.doi.org/10.1007/s12029-018-0168-2DOI Listing
December 2019
3 Reads

arthroplasty infection: beware of occult aortitis and malignancy.

Scott Med J 2018 Nov 28;63(4):132-139. Epub 2018 Aug 28.

Consultant Orthopaedic Surgeon, Department of Orthopaedic Surgery, Golden Jubilee National Hospital, UK.

Introduction: The species are responsible for life-threatening conditions such as tetanus, botulism and gas gangrene. is a rare cause of clinical infection, accounting for less than 1% of blood culture samples that test positive for . However, bacteraemia is associated with greater than 60% mortality and in over 80% of cases is associated with an underlying malignancy. Read More

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http://dx.doi.org/10.1177/0036933018793525DOI Listing
November 2018
46 Reads

Comparative efficacy of antibiotics in treating experimental Clostridium septicum infection.

Int J Antimicrob Agents 2018 Oct 14;52(4):469-473. Epub 2018 Sep 14.

Department of Veterans Affairs Medical Center, Boise, ID, USA; University of Washington School of Medicine, Seattle, WA, USA.

Clostridium septicum is a highly pathogenic microbe that causes gas gangrene in humans, and is the principal cause of spontaneous gas gangrene in patients with gastrointestinal maladies, including adenocarcinoma of the colon. Despite modern approaches to manage C. septicum infection, morbidity and mortality remain high (>60%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183020
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http://dx.doi.org/10.1016/j.ijantimicag.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467573PMC
October 2018
44 Reads

Characterization of two glycosyl hydrolases, putative prophage endolysins, that target Clostridium perfringens.

FEMS Microbiol Lett 2018 08;365(16)

Animal Biosciences and Biotechnology Laboratory, Agricultural Research Service, BARC, USDA, 10300 Baltimore Ave., Beltsville, MD, USA.

Clostridium perfringens, a spore-forming anaerobic bacterium, causes food poisoning and gas gangrene in humans and is an agent of necrotizing enteritis in poultry, swine and cattle. Endolysins are peptidoglycan hydrolases from bacteriophage that degrade the bacterial host cell wall causing lysis and thus harbor antimicrobial therapy potential. The genes for the PlyCP10 and PlyCP41 endolysins were found in prophage regions of the genomes from C. Read More

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http://dx.doi.org/10.1093/femsle/fny179DOI Listing
August 2018
46 Reads

A Case of Fatal Clostridial Necrotizing Fasciitis After Radical Prostatectomy.

Urology 2018 Dec 23;122:28-31. Epub 2018 Aug 23.

Division of Urologic Surgery, Duke University Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2018.06.043DOI Listing
December 2018
55 Reads

Successful treatment of hepatic gas gangrene by open drainage: A case report and review of the Japanese literature.

Int J Surg Case Rep 2018 30;49:121-125. Epub 2018 Jun 30.

Department of Surgery, Shonan Kamakura General Hospital, Japan.

Introduction: Liver gas gangrene is rare and has a low prognosis. This case, reports a successful treatment of hepatic gas gangrene using an open drainage technique, followed by antibiotics and hyperbaric oxygen therapy (HBO).

Presentation Of The Case: An 82-year-old male with a history of left hepatectomy and bile duct resection for hilar cholangiocarcinoma presented with chilling, lethargy and dyspnea. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037661PMC
June 2018
12 Reads

[Life-threatening intrauterine infection with Clostridium perfringens].

Ugeskr Laeger 2018 Jul;180(28)

In this case report, a 40-year-old woman with a history of a uterine leiomyoma presented with abdominal pain and fever. Initially, her symptoms were associated with a bleeding from an ovarian cyst seen on a CT scan of the abdomen showing free intraperitoneal fluid surrounding the internal genitals. Meanwhile, her blood cultures came out positive for Clostridium perfringens, and her condition deteriorated despite intravenous antibiotics. Read More

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July 2018
4 Reads

Mycotic aneurysm caused by Clostridium septicum in a patient with colorectal cancer.

Infection 2018 Oct 29;46(5):711-716. Epub 2018 May 29.

Department of Surgery, Amphia Ziekenhuis, Molengracht 21, 4818 CK, Breda, The Netherlands.

A mycotic aneurysm caused by a Clostridium septicum is a rare infection and has a strong association with colorectal cancer. If left untreated, the mortality rate of the first 24 h is high. This case report discusses the optimal treatment of emergency surgery combined with antibiotic treatment to improve survival. Read More

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http://link.springer.com/10.1007/s15010-018-1155-z
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http://dx.doi.org/10.1007/s15010-018-1155-zDOI Listing
October 2018
14 Reads

Whole genome analysis reveals the diversity and evolutionary relationships between necrotic enteritis-causing strains of Clostridium perfringens.

BMC Genomics 2018 May 22;19(1):379. Epub 2018 May 22.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, 3800, Australia.

Background: Clostridium perfringens causes a range of diseases in animals and humans including necrotic enteritis in chickens and food poisoning and gas gangrene in humans. Necrotic enteritis is of concern in commercial chicken production due to the cost of the implementation of infection control measures and to productivity losses. This study has focused on the genomic analysis of a range of chicken-derived C. Read More

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http://dx.doi.org/10.1186/s12864-018-4771-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964661PMC
May 2018
47 Reads