1,275 results match your criteria Clostridial Gas Gangrene


as a cause of gas gangrene in a trauma patient.

J Lab Physicians 2019 Jan-Mar;11(1):94-96

Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.

Gas gangrene is a necrotic infection of the skin and soft tissue that is associated with high mortality and often necessitating amputation to control the infection. Clostridial myonecrosis is most often cause of gas gangrene and usually present in settings of trauma, surgery, malignancy, and other underlying immunocompromised conditions. The most common causative organism of clostridial myonecrosis is followed by . Read More

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http://www.jlponline.org/text.asp?2019/11/1/94/254074
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http://dx.doi.org/10.4103/JLP.JLP_108_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437822PMC
April 2019
1 Read

Hepatic gas gangrene caused by Clostridium novyi.

Anaerobe 2019 Apr 4;57:90-92. Epub 2019 Apr 4.

Department of Laboratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan. Electronic address:

We report the case of a patient with advanced gastric cancer and multiple liver metastases, who presented with bacteremia and hepatic gas gangrene caused by Clostridium novyi (C. novyi). The gas gangrene caused abscesses to form within metastatic lesions. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.03.018DOI Listing
April 2019
1 Read

Sudden death due to gas gangrene caused by Clostridium septicum in goats.

BMC Vet Res 2018 Dec 18;14(1):406. Epub 2018 Dec 18.

Department of Microbiology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Turkey.

Background: Even though gas gangrene caused by Clostridium septicum in goats is mentioned in the classical textbooks, we have not managed to find any case description in the literature.

Case Presentation: Clinical signs resembling gas gangrene such as subcutaneous bloating, edema and crepitation were detected at various body parts of nine pregnant animals at the ages of 2-3 years on a hair goat farm (n = 170) located in Bingol province, Eastern Turkey. Five of these suspected animals with severe clinical symptoms died within 2 days. Read More

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http://dx.doi.org/10.1186/s12917-018-1747-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299590PMC
December 2018
5 Reads

[Host Defense against Bacterial Infection and Bacterial Toxin-induced Impairment of Innate Immunity].

Authors:
Masaya Takehara

Yakugaku Zasshi 2018 ;138(10):1249-1253

Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University.

 Whereas granulopoiesis during Gram-negative bacterial infection is accelerated through activation of toll-like receptor 4 (TLR4), it has not been elucidated whether Gram-positive bacterial infection can stimulate granulopoiesis. Using the well-known TLR2 agonist peptidoglycan (PGN), it was shown that neutrophils in bone marrow and spleen and plasma granulocyte colony-stimulating factor were increased in mice that had received intraperitoneal administration of PGN. Incorporation of bromodeoxyuridine into bone marrow neutrophils increased in mice administered PGN, demonstrating that PGN promotes granulopoiesis. Read More

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http://dx.doi.org/10.1248/yakushi.18-00102DOI Listing
October 2018
7 Reads

Clostridium septicum arthroplasty infection: beware of occult aortitis and malignancy.

Scott Med J 2018 Aug 28:36933018793525. Epub 2018 Aug 28.

3 Consultant Orthopaedic Surgeon, Department of Orthopaedic Surgery, Golden Jubilee National Hospital, UK.

Introduction The Clostridia species are responsible for life-threatening conditions such as tetanus, botulism and gas gangrene. Clostridium septicum is a rare cause of clinical infection, accounting for less than 1% of blood culture samples that test positive for Clostridia. However, C. Read More

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http://dx.doi.org/10.1177/0036933018793525DOI Listing
August 2018
28 Reads

Comparative efficacy of antibiotics in treating experimental Clostridium septicum infection.

Int J Antimicrob Agents 2018 Oct 14;52(4):469-473. Epub 2018 Sep 14.

Department of Veterans Affairs Medical Center, Boise, ID, USA; University of Washington School of Medicine, Seattle, WA, USA.

Clostridium septicum is a highly pathogenic microbe that causes gas gangrene in humans, and is the principal cause of spontaneous gas gangrene in patients with gastrointestinal maladies, including adenocarcinoma of the colon. Despite modern approaches to manage C. septicum infection, morbidity and mortality remain high (>60%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183020
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http://dx.doi.org/10.1016/j.ijantimicag.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467573PMC
October 2018
27 Reads

Characterization of two glycosyl hydrolases, putative prophage endolysins, that target Clostridium perfringens.

FEMS Microbiol Lett 2018 Aug;365(16)

Animal Biosciences and Biotechnology Laboratory, Agricultural Research Service, BARC, USDA, 10300 Baltimore Ave., Beltsville, MD, USA.

Clostridium perfringens, a spore-forming anaerobic bacterium, causes food poisoning and gas gangrene in humans and is an agent of necrotizing enteritis in poultry, swine and cattle. Endolysins are peptidoglycan hydrolases from bacteriophage that degrade the bacterial host cell wall causing lysis and thus harbor antimicrobial therapy potential. The genes for the PlyCP10 and PlyCP41 endolysins were found in prophage regions of the genomes from C. Read More

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http://dx.doi.org/10.1093/femsle/fny179DOI Listing
August 2018
11 Reads

Successful treatment of hepatic gas gangrene by open drainage: A case report and review of the Japanese literature.

Int J Surg Case Rep 2018 30;49:121-125. Epub 2018 Jun 30.

Department of Surgery, Shonan Kamakura General Hospital, Japan.

Introduction: Liver gas gangrene is rare and has a low prognosis. This case, reports a successful treatment of hepatic gas gangrene using an open drainage technique, followed by antibiotics and hyperbaric oxygen therapy (HBO).

Presentation Of The Case: An 82-year-old male with a history of left hepatectomy and bile duct resection for hilar cholangiocarcinoma presented with chilling, lethargy and dyspnea. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037661PMC
June 2018
4 Reads

Mycotic aneurysm caused by Clostridium septicum in a patient with colorectal cancer.

Infection 2018 Oct 29;46(5):711-716. Epub 2018 May 29.

Department of Surgery, Amphia Ziekenhuis, Molengracht 21, 4818 CK, Breda, The Netherlands.

A mycotic aneurysm caused by a Clostridium septicum is a rare infection and has a strong association with colorectal cancer. If left untreated, the mortality rate of the first 24 h is high. This case report discusses the optimal treatment of emergency surgery combined with antibiotic treatment to improve survival. Read More

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http://link.springer.com/10.1007/s15010-018-1155-z
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http://dx.doi.org/10.1007/s15010-018-1155-zDOI Listing
October 2018
7 Reads

Whole genome analysis reveals the diversity and evolutionary relationships between necrotic enteritis-causing strains of Clostridium perfringens.

BMC Genomics 2018 May 22;19(1):379. Epub 2018 May 22.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, 3800, Australia.

Background: Clostridium perfringens causes a range of diseases in animals and humans including necrotic enteritis in chickens and food poisoning and gas gangrene in humans. Necrotic enteritis is of concern in commercial chicken production due to the cost of the implementation of infection control measures and to productivity losses. This study has focused on the genomic analysis of a range of chicken-derived C. Read More

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http://dx.doi.org/10.1186/s12864-018-4771-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964661PMC
May 2018
13 Reads

Mechanisms of Action and Cell Death Associated with Toxins.

Toxins (Basel) 2018 05 22;10(5). Epub 2018 May 22.

California Animal Health and Food Safety Laboratory, San Bernardino Branch, School of Veterinary Medicine, University of California-Davis, San Bernardino, CA 92408, USA.

uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (CPE), and necrotic B-like (NetB) toxins. CPA is the main virulence factor involved in gas gangrene in humans, whereas its role in animal diseases is limited and controversial. Read More

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http://dx.doi.org/10.3390/toxins10050212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983268PMC
May 2018
29 Reads

Gas Gangrene of Malignant Mixed Mullerian Tumor of Ovary Caused by Clostridium perfringens.

J Emerg Med 2018 06 20;54(6):e133-e135. Epub 2018 Apr 20.

Emergency Medicine Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.jemermed.2018.02.037DOI Listing
June 2018
4 Reads

Ethanolamine utilization supports Clostridium perfringens growth in infected tissues.

Microb Pathog 2018 Jun 11;119:200-207. Epub 2018 Apr 11.

Department of Microbiology, Faculty of Medicine, Kagawa University, 1750-1 Miki, Kagawa, 761-0793, Japan. Electronic address:

Clostridium perfringens possesses the ethanolamine (EA) utilization (eut) system encoded within the eut operon, which utilizes the EA as a carbon, nitrogen and energy source. To determine the role of the eut system in C. perfringens growth, an in-frame deletion of the eutABC genes was made in strain HN13 to generate the eutABC-deleted mutant strain HY1701. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.04.017DOI Listing
June 2018
8 Reads

Concurrent Host-Pathogen Transcriptional Responses in a Murine Myonecrosis Infection.

MBio 2018 03 27;9(2). Epub 2018 Mar 27.

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia

To obtain an insight into host-pathogen interactions in clostridial myonecrosis, we carried out comparative transcriptome analysis of both the bacterium and the host in a murine infection model, which is the first time that such an investigation has been conducted. Analysis of the host transcriptome from infected muscle tissues indicated that many genes were upregulated compared to the results seen with mock-infected mice. These genes were enriched for host defense pathways, including Toll-like receptor (TLR) and Nod-like receptor (NLR) signaling components. Read More

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http://dx.doi.org/10.1128/mBio.00473-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874911PMC
March 2018
5 Reads

Atraumatic Clostridial Myonecrosis in an Immunocompromised Host.

J Emerg Med 2018 06 10;54(6):e121-e123. Epub 2018 Mar 10.

Division of Community Internal Medicine, Mayo Clinic, Jacksonville, Florida.

Background: Necrotizing fasciitis is usually associated with a surgical or traumatic wound. Clostridial myonecrosis is an uncommon but deadly infection that can develop in the absence of a wound and is often associated with occult gastrointestinal cancer or immunocompromise, or both.

Case Report: We report a case of catastrophic atraumatic Clostridium septicum infection in an immunocompromised host. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.01.036DOI Listing
June 2018
8 Reads

Sliding free transverse rectus abdominis myocutaneous flap for closure of a massive abdominal wall defect: A case report.

Microsurgery 2019 Feb 16;39(2):174-177. Epub 2018 Feb 16.

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Heidelberg, Germany.

Despite considerable advances in reconstructive surgery, massive abdominal wall defects continue to pose a significant surgical challenge. We report the case of a 72-year-old morbidly obese female patient with Clostridium septicum-related gas gangrene of the abdominal wall. After multidisciplinary treatment and multiple extensive debridements, a massive full-thickness defect (40 cm × 35 cm) of the right abdominal wall was present. Read More

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http://dx.doi.org/10.1002/micr.30309DOI Listing
February 2019
7 Reads

Gas gangrene of the eye: endogenous Clostridium perfringens endophthalmitis.

Med J Aust 2018 02;208(2):64

Save Sight Institute, Sydney, NSW.

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February 2018
43 Reads

Metabolic dependent and independent pH-drop shuts down VirSR quorum sensing in Clostridium perfringens.

J Biosci Bioeng 2018 May 17;125(5):525-531. Epub 2018 Jan 17.

Laboratory of Microbial Technology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka 812-8581, Japan. Electronic address:

Clostridium perfringens produces various exotoxins and enzymes that cause food poisoning and gas gangrene. The genes involved in virulence are regulated by the agr-like quorum sensing (QS) system, which consists of a QS signal synthesis system and a VirSR two-component regulatory system (VirSR TCS) which is a global regulatory system composed of signal sensor kinase (VirS) and response regulator (VirR). We found that the perfringolysin O gene (pfoA) was transiently expressed during mid-log phase of bacterial growth; its expression was rapidly shut down thereafter, suggesting the existence of a self-quorum quenching (sQQ) system. Read More

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http://dx.doi.org/10.1016/j.jbiosc.2017.12.019DOI Listing
May 2018
17 Reads

Massive intravascular haemolysis due to .

BMJ Case Rep 2018 Jan 4;2018. Epub 2018 Jan 4.

Emergency and General Internal Medicine, Hitachinaka General Hospital, Hitachinaka, Japan.

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http://dx.doi.org/10.1136/bcr-2017-223464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786929PMC
January 2018
5 Reads

Immunization with a nontoxic naturally occurring Clostridium perfringens alpha toxin induces neutralizing antibodies in rabbits.

Anaerobe 2018 Feb 12;49:48-52. Epub 2017 Dec 12.

Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:

Clostridium perfringens alpha toxin, encoded by plc gene, has been implicated in gas gangrene, a life threatening infection. Vaccination is considered one of the best solutions against Clostridium infections. Although studies have identified many low quality clostridial vaccines, the use of recombinant proteins has been considered a promising alternative. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2017.12.004DOI Listing
February 2018
12 Reads

Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model.

Toxicon 2018 Jan 12;141:112-117. Epub 2017 Dec 12.

Department of Pharmacology, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. Electronic address:

Cases of Clostridium perfringens septicemia, such as liver abscess, often develop a rapidly progressive intravascular hemolysis and coagulation; the mortality rate with current standard care including antibiotics and surgery is high. Herein, we firstly investigated the effects of gas gangrene antitoxin (GGA) (antitoxin against C. perfringens) and recombinant human soluble thrombomodulin (rTM) on the hemolysis, coagulation status, inflammatory process, and mortality in α-toxin-treated rats. Read More

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http://dx.doi.org/10.1016/j.toxicon.2017.12.043DOI Listing
January 2018
13 Reads

Complete genome sequences of Del1 strain isolated from chickens affected by necrotic enteritis.

Gut Pathog 2017 21;9:69. Epub 2017 Nov 21.

Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-US Department of Agriculture, Beltsville, 10300 Baltimore Avenue, MD 20705 USA.

Background: is ubiquitous in nature. It is a normal inhabitant in the intestinal tract of animals and humans. As the primary etiological agent of gas gangrene, necrosis and bacteremia, causes food poisoning, necrotic enteritis (NE), and even death. Read More

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http://dx.doi.org/10.1186/s13099-017-0217-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699181PMC
November 2017
17 Reads

Deadly combination: and colorectal malignancy.

BMJ Case Rep 2017 Dec 2;2017. Epub 2017 Dec 2.

General Surgery, University Hospital Limerick, Limerick, Ireland.

Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated is a rare cause of gas gangrene. This case outlines an initial presentation of colonic malignancy as gas gangrene from infection. Read More

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http://dx.doi.org/10.1136/bcr-2017-222759DOI Listing
December 2017
26 Reads

Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report.

J Med Case Rep 2017 Nov 28;11(1):332. Epub 2017 Nov 28.

Department of Surgery, University of Illinois at Chicago, Chicago, 60612, IL, USA.

Background: Fusobacterium necrophorum is a common agent of disease in humans, but the occurrence of primary infections outside the head and neck area is extremely rare. While infection with Fusobacterium necrophorum has a rather benign course above the thorax, the organism is capable of producing very severe disease when located in unusual sites, including various forms of septic thrombophlebitis. No infections of the leg have been documented before; thus, antibiotic coverage for Fusobacterium is currently not recommended in this area. Read More

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http://dx.doi.org/10.1186/s13256-017-1493-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704428PMC
November 2017
24 Reads

Liver abscess and sepsis caused by Clostridium perfringens and Klebsiella oxytoca.

Int J Surg Case Rep 2017 5;41:180-183. Epub 2017 Nov 5.

Department of General, Visceral and Cancer Surgery, HELIOS Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany. Electronic address:

Introduction: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i. Read More

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http://dx.doi.org/10.1016/j.ijscr.2017.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686218PMC
November 2017
31 Reads

Uterine infection related to gynecologic malignancy.

Gynecol Oncol Rep 2017 Nov 21;22:55-57. Epub 2017 Sep 21.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA 52242, United States.

Uterine gas gangrene caused by is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality. Read More

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http://dx.doi.org/10.1016/j.gore.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635240PMC
November 2017
14 Reads

Rare postoperative complication: septic shock following elective abdominal surgery.

BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.

Department of General Surgery, Bedford Hospital NHS Trust, Bedford, UK.

Postoperative infections are one of the most common complications in general surgery, and while rates have reduced with the routine administration of perioperative antibiotics, around 5% of patients undergoing a surgical procedure will develop an infective complication. The Gram-positive, obligate anaerobe, , is a well-known pathogen that forms part of both the environmental and gastrointestinal flora. While more commonly associated with food poisoning, anaerobic cellulitis and traumatic gas gangrene, rare cases of spontaneous non-traumatic gas gangrene of abdominal viscera have also been recorded. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22198
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http://dx.doi.org/10.1136/bcr-2017-221980DOI Listing
October 2017
11 Reads

Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors.

Int J Biol Macromol 2018 Feb 6;107(Pt B):1491-1500. Epub 2017 Oct 6.

Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India. Electronic address:

Metalloproteases are a class of proteases having metal ion(s) at their catalytic sites. Bacterial collagenases are involved in human gas gangrene, periodontal diseases, food etc. The Clostridium collagenase occurs in two isoforms COL_G and Col_H. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2017.10.008DOI Listing
February 2018
17 Reads

Anal Canal Gas Gangrene in Aplastic Anaemia: Rare yet Lethal Entity - A Caveat.

Cureus 2017 Jul 13;9(7):e1469. Epub 2017 Jul 13.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentation to be reported in literature. Read More

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http://dx.doi.org/10.7759/cureus.1469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597065PMC
July 2017
13 Reads

Mode of action of plectasin-derived peptides against gas gangrene-associated Clostridium perfringens type A.

PLoS One 2017 21;12(9):e0185215. Epub 2017 Sep 21.

Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing, China.

NZ2114 and MP1102 are novel plectasin-derived peptides with potent activity against Gram-positive bacteria. The antibacterial characteristics and mechanism of NZ2114 and MP1102 against gas gangrene-associated Clostridium perfringens were studied for the first time. The minimal inhibitory concentration and minimal bactericidal concentration of NZ2114 and MP1102 against resistant C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185215PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608353PMC
October 2017
23 Reads

Presence of periaortic gas in Clostridium septicum-infected aortic aneurysm aids in early diagnosis: a case report and systematic review of the literature.

J Med Case Rep 2017 Sep 21;11(1):268. Epub 2017 Sep 21.

Department of Emergency and Critical Care Medicine, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama, Fukushima, 963-8558, Japan.

Background: Clostridium septicum-infected aortic aneurysm is a fatal and rare disease. We present a fatal case of C. septicum-infected aortic aneurysm and a pertinent literature review with treatment suggestions for reducing mortality rates. Read More

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http://dx.doi.org/10.1186/s13256-017-1422-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607595PMC
September 2017
10 Reads

Non-clostridial gas gangrene in a patient with poorly controlled type 2 diabetes mellitus on hemodialysis.

Acta Diabetol 2018 01 5;55(1):99-101. Epub 2017 Sep 5.

Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

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http://dx.doi.org/10.1007/s00592-017-1038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794821PMC
January 2018
35 Reads

Clostridium perfringens related spleen gangrene.

Intensive Care Med 2017 11 7;43(11):1730-1731. Epub 2017 Aug 7.

Service de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 75012, Paris, France.

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http://dx.doi.org/10.1007/s00134-017-4899-5DOI Listing
November 2017
2 Reads

Spontaneous C. septicum gas gangrene: A literature review.

Anaerobe 2017 Dec 2;48:165-171. Epub 2017 Aug 2.

Boise VA Medical Center, Boise, ID 83702, USA. Electronic address:

As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2017.07.008DOI Listing
December 2017
39 Reads

Akute Beinschmerzen mit fulminantem Verlauf bei einem 69-Jährigen.

Praxis (Bern 1994) 2017 Jul;106(15):837-840

1 Departement perioperative Medizin, Klinik für Intensivmedizin, Kantonsspital Olten.

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http://dx.doi.org/10.1024/1661-8157/a002744DOI Listing
July 2017
9 Reads

Gas Gangrene of Different Origin Associated with Clostridium perfringens Type A in Three Patients Simultaneously Hospitalized in a Single Department of Orthopedics and Traumatology in Poland.

Pol J Microbiol 2017 Jan;65(4):399-406

Department of Infection Epidemiology, Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.

The objective of the study was to perform a comparative analysis of phenotypic and genetic similarity, determination of resistance profiles, detection of toxin-encoding genes and molecular typing of Clostridium perfringens isolates originating from patients with gas gangrene. The study encompassed three patients with a clinical and microbiological diagnosis of gas gangrene who were hospitalized in one of the hospitals of the Kujawsko-Pomorskie province in the same period of time between 8 April 2015 and 20 April 2015. The three C. Read More

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http://dx.doi.org/10.5604/17331331.1227665DOI Listing
January 2017
58 Reads

Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities.

Curr Microbiol 2017 Nov 21;74(11):1278-1286. Epub 2017 Jul 21.

Haffkine Biopharmaceutical Corporation Limited, Pune, India.

Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities. Read More

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http://dx.doi.org/10.1007/s00284-017-1313-zDOI Listing
November 2017
8 Reads

A rapid qualitative assay for detection of Clostridium perfringens in canned food products.

Acta Biochim Pol 2017 9;64(2):207-213. Epub 2017 Jun 9.

Department of Biotechnology, P D Patel Institute of Applied Sciences, Charotar University of Science and Technology (CHARUSAT), Changa-388421, India.

Clostridium perfringens (MTCC 1349) is a Gram-positive, anaerobic, endospore forming, and rod-shaped bacterium. This bacterium produces a variety of toxins under strict anaerobic environment. C. Read More

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http://dx.doi.org/10.18388/abp.2015_1169DOI Listing
August 2017
9 Reads

Complete genome sequence of CBA7123 isolated from a faecal sample from Korea.

Gut Pathog 2017 2;9:32. Epub 2017 Jun 2.

Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, 61755 Republic of Korea.

Background: is an opportunistic human pathogen that causes necrotic enteritis, mild diarrhea, clostridial myonecrosis or gas gangrene, sepsis, etc. In this study, we aim to determine the pathogenesis of this bacterium at the genomic level. The genome of strain CBA7123 was sequenced, and a comparative genomic analysis between strain CBA7123 and four other related strains was performed. Read More

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http://dx.doi.org/10.1186/s13099-017-0181-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457660PMC
June 2017
38 Reads

Plain x-ray films in soft tissue infections.

Pan Afr Med J 2017;26:149. Epub 2017 Mar 15.

Serviço de Cirurgia 1, Centro Hospitalar Lisboa Central, Rua José António Serrano, 1150-199 Lisboa, Portugal.

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http://dx.doi.org/10.11604/pamj.2017.26.149.11393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429462PMC
March 2017
19 Reads

A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens α-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis.

Probiotics Antimicrob Proteins 2018 06;10(2):251-257

Department of Anaerobic Bacterial Vaccine Research and Production, Kerman Branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran.

The alpha-toxin is one of the virulence factors of Clostridium perfringens for gas gangrene in humans and animals or necrotic enteritis in poultry. The C-terminal domain of this toxin ( cpa ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid. This surface-expressing plasmid was electroporated into Lactobacillus casei ATCC 393, generating the recombinant L. Read More

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http://link.springer.com/10.1007/s12602-017-9276-8
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http://dx.doi.org/10.1007/s12602-017-9276-8DOI Listing
June 2018
25 Reads

Identification, Isolation, and Phylogenetic Analysis of Clostridium perfringens Type A and Type C from Wild Boar ( Sus scrofa ) in the People's Republic of China.

J Wildl Dis 2017 07 22;53(3):642-648. Epub 2017 Mar 22.

1 National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, No. 1-5 Beichenxi Road, Chaoyang District, Beijing, People's Republic of China 100101.

Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). Read More

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http://dx.doi.org/10.7589/2016-08-199DOI Listing
July 2017
13 Reads

A fatal Clostridium perfringens infection with hemolysis after chemotherapy in an adolescent.

Arch Argent Pediatr 2017 04;115(2):e92-e95

Department of Pediatrics, Pediatric Intensive Care Unit, Faculty of Medicine, Hacettepe University.

Gas gangrene, clostridial myonecrosis, is one of the most serious infectious diseases, characterized by rapidly progressive destruction of deep soft tissues and production of gas within the tissues. We presented a case of fatal spontaneous gas gangrene due to Clostridium perfringens in a patient with acute lymphoblastic leukemia during remission induction chemotherapy phase. Read More

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http://dx.doi.org/10.5546/aap.2017.eng.e92DOI Listing
April 2017
16 Reads

[Necrotizing fasciitis of the upper and lower extremities].

Chirurg 2017 Apr;88(4):353-366

Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgie-Zentrum, operatives Referenzzentrum für Gliedmaßentumoren, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.

Necrotizing fasciitis is a potentially fatal soft tissue infection that may affect the upper and lower extremities, scrotum, perineum and abdominal wall. Typically, the infection demonstrates rapid spreading along the fascial planes leading to sepsis with mortality rates of 15-46%. Without adequate treatment, the mortality rate increases to close to 100%. Read More

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http://dx.doi.org/10.1007/s00104-017-0397-0DOI Listing
April 2017
6 Reads

Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin.

Toxicon 2017 May 1;130:79-86. Epub 2017 Mar 1.

Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, Jilin Province, China. Electronic address:

Alpha-toxin produced by Clostridium perfringens is an important virulence factor, causing food poisoning and gas gangrene in humans. As such, it is considered a potential bioterrorism threat. To date, there is still no human effective therapeutic drug against alpha-toxin. Read More

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http://dx.doi.org/10.1016/j.toxicon.2017.02.021DOI Listing
May 2017
26 Reads

Effect of continuous sub-culturing on infectivity of Clostridium perfringens ATCC13124 in mouse gas gangrene model.

Folia Microbiol (Praha) 2017 Jul 17;62(4):343-353. Epub 2017 Feb 17.

Biotechnology Division, Defence Research and Development Establishment, Gwalior, 474002, India.

Clostridium perfringens is a Validated Biological Agent and a pathogen of medical, veterinary, and military significance. Gas gangrene is the most destructive of all the clostridial diseases and is caused by C. perfringens type A strains wherein the infection spreads quickly (several inches per hour) with production of gas. Read More

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http://dx.doi.org/10.1007/s12223-017-0503-1DOI Listing
July 2017
9 Reads

Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis.

Vet Res 2017 02 16;48(1). Epub 2017 Feb 16.

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.

Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small intestinal haemorrhage, necrosis and mucosal neutrophil infiltration. The common assumption that, when causing intestinal disease, C. Read More

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http://dx.doi.org/10.1186/s13567-017-0413-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314468PMC
February 2017
23 Reads

Lipidomic profile of GM95 cell death induced by Clostridium perfringens alpha-toxin.

Chem Phys Lipids 2017 03 16;203:54-70. Epub 2017 Jan 16.

Unidad de Biofísica (CSIC, UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, Aptdo. 644, 48080 Bilbao, Spain. Electronic address:

Clostridium perfringens alpha-toxin (ATX) is considered as a prototype of cytotoxic bacterial phospholipases C, and is the major virulence factor in C. perfringens-induced gas gangrene. It is known that, depending on the dose, ATX causes membrane disruption and cytolysis or only limited hydrolysis of its substrates. Read More

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http://dx.doi.org/10.1016/j.chemphyslip.2017.01.002DOI Listing
March 2017
6 Reads