123,835 results match your criteria Clinics in colon and rectal surgery[Journal]


Cumulative live birth rate prognosis based on the number of aspirated oocytes in previous ART cycles.

Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Kettegård Allé 26, Hvidovre, Denmark.

Study Question: Is the number of aspirated oocytes in the first ART cycle associated with the cumulative live birthrates (CLBR) in subsequent cycles?

Summary Answer: The number of aspirated oocytes in the first cycle was associated with CLBR in subsequent cycles. Previous treatment response predicts outcome in future cycles.

What Is Known Already: Previous reports have shown a positive association between the number of retrieved oocytes and live birthrate per fresh treatment cycle. Read More

View Article
December 2018

Can a patient-focussed bookings approach reduce patient non-attendance in postnatal and continence physiotherapy?

J Public Health (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Innovation and Improvement, Monash Health, Clayton, Australia.

Background: There are unique life-stage and psychosocial barriers to attendance for women referred for postnatal and continence physiotherapy. These barriers affect access to care, clinic utilization and patient waiting lists. In a patient-focused bookings system, the patient is invited to contact the health service to book their appointment at a time and day that suits them, increasing patient choice and engagement in the booking process. Read More

View Article
December 2018

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Johns Hopkins University School of Medicine.

Objectives: The gut microbiome is believed to play a role in the susceptibility to and treatment of Clostridium difficile infections (CDIs). It is, however, unknown whether the gut microbiome is also affected by asymptomatic C difficile colonization. Our study aimed to evaluate the fecal microbiome of children based on C difficile colonization, and CDI risk factors, including antibiotic use and comorbid inflammatory bowel disease (IBD). Read More

View Article
December 2018

Systematic review addressing nurse practitioner reimbursement policy: Part one of a four-part series on critical topics identified by the 2015 nurse practitioner research agenda.

J Am Assoc Nurse Pract 2018 Dec;30(12):673-682

PediatriCare of Northern Virginia, Haymarket, Virginia George Mason University/Mason and Partners Clinics, Fairfax, Virginia.

Background And Purpose: The growth and sustainability of nurse practitioners (NPs) requires transparent, fair and equitable reimbursement policies. Complicating this issue is variation in reimbursement policy within and across federal, state, and other payers. Even with explicit regulations, there remain questions on how reimbursement policies are covertly operationalized in practice. Read More

View Article
December 2018

Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

View Article
December 2018

[Eating disorders and fertility].

Psychiatr Hung 2018 ;33(4):331-339

Semmelweis Egyetem, Magatartástudomanyi Intezet, Budapest, Hungary, E-mail:

Common gynecological complications of various eating disorders include infertility, unwanted pregnancy, miscarriage, sexual dysfunction and complications in the treatment of gynecological cancers. Women with eating disorders typically see their gynecologists because of menstrual and other endocrine disorders or unexplained gastrointestinal symptoms, and often report on psychological symptoms (anxiety, depression or decreased libido). In spite of anovulation, menstruation may occur and ovulation without menstruation may be possible, which may lead to an increased incidence of unwanted pregnancies in case of prior or current eating disorders. Read More

View Article
January 2018

Autophagy and intermittent fasting: the connection for cancer therapy?

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e814s. Epub 2018 Dec 10.

Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, SP, BR.

Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Read More

View Article
December 2018

Natural products as new antimitotic compounds for anticancer drug development.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e813s. Epub 2018 Dec 10.

Laboratorio de Oncologia Experimental, Nucleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceara, Fortaleza, CE, BR.

Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. Read More

View Article
December 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

View Article
December 2018

Radiotherapy and immune response: the systemic effects of a local treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e557s. Epub 2018 Dec 10.

Departamento de Radiologia e Oncologia, Divisao de Radioterapia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Technological developments have allowed improvements in radiotherapy delivery, with higher precision and better sparing of normal tissue. For many years, it has been well known that ionizing radiation has not only local action but also systemic effects by triggering many molecular signaling pathways. There is still a lack of knowledge of this issue. Read More

View Article
December 2018

New method of sentinel lymph node biopsy in transoral robotic surgery for oropharyngeal squamous cell carcinoma.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e550s. Epub 2018 Dec 10.

Cirurgia de Cabeca e Pescoco, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR.

View Article
December 2018
1 Read

Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

View Article
December 2018
1 Read

Surgical treatment of gastric cancer: a 10-year experience in a high-volume university hospital.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e543s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Surgery remains the cornerstone treatment modality for gastric cancer, the fifth most common type of tumor in Brazil. The aim of this study was to analyze the surgical treatment outcomes of patients with gastric cancer who were referred to a high-volume university hospital.

Methods: We reviewed all consecutive patients who underwent any surgical procedure due to gastric cancer from a prospectively collected database. Read More

View Article
December 2018

Value-based medicine in oncology: the importance of perspective in the emerging value frameworks.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e470s. Epub 2018 Dec 10.

Centro de Investigacao Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Recently, professional and healthcare-related entities have launched frameworks designed to assess the value of cancer innovations in multistakeholder decision processes. Among the most visible entities that propose and implement value frameworks in oncology are the European Society of Medical Oncology (ESMO), the American Society of Clinical Oncology (ASCO), the Memorial Sloan Kettering Cancer Center (MSKCC) and the National Comprehensive Cancer Network (NCCN). However, these value frameworks have been criticized for conceptual inconsistencies, inability to include a greater variety of value criteria, and inadequate explanation of the uncertainty approach used in the modeling process. Read More

View Article
December 2018

Current concepts in multiparametric magnetic resonance imaging for active surveillance of prostate cancer.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e464s. Epub 2018 Dec 10.

Grupo de Uro-Oncologia, Departamento de Urologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

View Article
December 2018

Use of vitamin D and infection in patients with chronic kidney disease.

Rev Bras Enferm 2018 ;71(suppl 6):2792-2799

Universidade Federal de São Paulo, Paulista Nursing School. São Paulo, São Paulo, Brazil.

Objective: To evaluate the effectiveness of vitamin D supplementation as protection factor against infection of patients with chronic kidney disease on conservative treatment.

Method: Retrospective cohort study carried out between 2013 and 2016 in the Conservative Treatment Outpatient Clinics (Ambulatório de Tratamento Conservador) of the Hypertension and Kidney Hospital (Hospital do Rim e Hipertensão) of the Universidade Federal de São Paulo. Data on sociodemographic factors, comorbidity, infection episodes and use or nonuse of vitamin D supplementation for at least 6 months were collected from medical records. Read More

View Article
January 2018

Prevalence of self-reported trauma in a sample of Iranian children is low and unrelated to parents' education or current employment status.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

University of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland.

Objective: In Western countries, the prevalence of childhood trauma (CT) ranges from 15 to 25%. CT might be indirectly associated with lower parental socioeconomic status and educational attainments. The aims of this cross-sectional study were fourfold: to assess prevalence of CT in a large sample of Iranian children; to compare the Iranian prevalence rates with those of Western countries; to explore gender-specific patterns; and to explore possible socioeconomic predictors. Read More

View Article
December 2018
1 Read

Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation.

Neural Regen Res 2019 Mar;14(3):485-490

Division of Physiology and Neuroscience, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Alcohol, a widely abused drug, has deleterious effects on the immature nervous system. This study investigates the effect of chronic in vitro ethanol exposure on the metabolism of immature rat cerebellar granular cells (CGCs) and on their response to oxygen-glucose deprivation (OGD). Primary CGC cultures were exposed to ethanol (100 mM in culture medium) or to control ethanol-free medium starting day one in vitro (DIV1). Read More

View Article

Dynamic prediction of transition to psychosis using joint modelling.

Schizophr Res 2018 Dec 7;202:333-340. Epub 2018 Jul 7.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.

Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such research has only employed baseline predictors, i.e. Read More

View Article
December 2018

Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis.

Am J Cardiol 2019 Jan 27;123(1):139-144. Epub 2018 Sep 27.

Division of Cardiology, Wayne State University/Detroit Medical Center, Detroit, Michigan.

A significant proportion of patients with acute myocarditis experience sudden cardiac death presumably due to cardiac arrhythmia. In this study, we explore the burden, the predictors of arrhythmia in acute myocarditis and the association between arrhythmias and adverse in-hospital outcomes. After evaluating the frequency of various tachyarrhythmias and bradyarrhythmia in myocarditis population, we built a logistic model to determine the independent predictors of arrhythmias in myocarditis and a 1:1 propensity-matched analysis to examine the impact of arrhythmias. Read More

View Article
January 2019

Comparing Maternal Serum Screening Markers Among IVF and Spontaneous Conceptions in Ontario Through Registry Data.

J Obstet Gynaecol Can 2018 Dec 26;40(12):1608-1617. Epub 2018 Oct 26.

BORN (Better Outcomes Registry and Network) Ontario, Ottawa, ON; Ottawa Hospital Research Institute, Ottawa, ON; OMNI Research Group, Ottawa, ON; CHEO (Children's Hospital of Eastern Ontario) Research Institute, Ottawa, ON; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON.

Objective: The objectives of this study were as follows: (1) to investigate the accuracy of IVF identification on the prenatal screening record from prenatal screening laboratories; (2) to compare the screening markers in IVF and non-IVF pregnancies in the population of Ontario; and (3) to propose more appropriate IVF adjustment factors for the Ontario population.

Methods: Two years of IVF treatment, data from all fertility clinics in Ontario were merged with the corresponding prenatal screening data from all five prenatal screening labs. New adjustment factors for IVF were developed for each maternal serum screening marker and nuchal translucency measurement. Read More

View Article
December 2018

The 2018 Nobel Prize in Physiology or Medicine: An exemplar of bench to bedside in immunology.

Authors:
Zuhair K Ballas

J Allergy Clin Immunol 2018 Dec 26;142(6):1752-1753. Epub 2018 Oct 26.

University of Iowa Hospitals & Clinics and the Iowa City VA Medical Center, Iowa City, Iowa. Electronic address:

View Article
December 2018

Cohort study of risk factors for 30-day readmission after abdominal aortic aneurysm repair.

Vasa 2018 Dec 12:1-11. Epub 2018 Dec 12.

1 Division of Vascular Surgery, University of Missouri Hospitals & Clinics, Columbia, MO, USA.

Background: We conducted a retrospective cohort study of thirty-day readmission after abdominal aortic aneurysm (AAA) repair.

Patients And Methods: Inpatients (2009-2016) undergoing elective AAA repair were selected from the multicenter Cerner Health Facts® database using ICD-9 procedure codes. We identified characteristics associated with 30-day readmission with chi-square analysis and logistic regression. Read More

View Article
December 2018

Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Pampulha, PO Box 359, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

Objectives: To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on cytokines levels and its relation to periodontal status.

Materials And Methods: Ninety-one eligible individuals were selected from a 6-year prospective study with 212 individuals in PMT. From this total, 28 regular compliers (RC) were randomly selected and matched for age and gender with 28 irregular compliers (IC). Read More

View Article
December 2018

A 9-Week Nordic and Free Walking Improve Postural Balance in Parkinson's Disease.

Sports Med Int Open 2018 Apr 8;2(2):E28-E34. Epub 2018 Jan 8.

Federal University of Rio Grande do Sul, Exercise Research Laboratory, Porto Alegre, Brazil.

Aerobic training has a neuroprotective effect in people with Parkinson's disease. Recent evidence indicates that Nordic walking seems a promising alternative due to positive outcomes in functional mobility. However, the effects of Nordic walking compared to free walking on static and functional balance parameters are still unknown. Read More

View Article

Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito.

Front Nutr 2018 27;5:112. Epub 2018 Nov 27.

Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese traditional herbal medicines for improving various types of metabolic disorders. Read More

View Article
November 2018

School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents.

BMJ Open Gastroenterol 2018 24;5(1):e000236. Epub 2018 Nov 24.

Division of Epidemiology and Biometry, Medical Faculty, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Objective: We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk.

Design: This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Read More

View Article
November 2018

Progression of subclinical and clinical cardiovascular disease in a UK SLE cohort: the role of classic and SLE-related factors.

Lupus Sci Med 2018 17;5(1):e000267. Epub 2018 Nov 17.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Objectives: We aimed to describe the rate and determinants of carotid plaque progression and the onset of clinical cardiovascular disease (CVD) in a UK SLE cohort.

Methods: Female patients with SLE of white British ancestry were recruited from clinics in the North-West of England and had a baseline clinical and CVD risk assessment including measurement of carotid intima-media thickness (CIMT) and plaque using B-mode Doppler ultrasound. Patients were followed up (>3. Read More

View Article
November 2018

The subjective perception of past, present, and future time in patients with Alzheimer's disease: a qualitative study.

Neuropsychiatr Dis Treat 2018 22;14:3185-3192. Epub 2018 Nov 22.

Division of Neurology, Department of Internal Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan,

Background: The relationship between dementia and time perception impairment is unknown.

Aim: This study aims to explore subjective perception of the passage of time in patients with Alzheimer's disease (AD).

Methods: We conducted semi-structured interviews with 11 AD patients. Read More

View Article
November 2018

Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.

Nat Commun 2018 12 11;9(1):5278. Epub 2018 Dec 11.

Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan.

Regulation of intracellular pH is critically important for many cellular functions. The quantification of proton extrusion in different types of cells and physiological conditions is pivotal to fully elucidate the mechanisms of pH homeostasis. Here we show the use of gold nanoparticles (AuNP) to create a high spatial resolution sensor for measuring extracellular pH in proximity of the cell membrane. Read More

View Article
December 2018

Sexuality and intimacy in ALS: systematic literature review and future perspectives.

J Neurol Neurosurg Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology and Laboratory of Neuroscience, Istituto Auxologico Italiano, IRCCS, Milan, Italy

Several features of amyotrophic lateral sclerosis (ALS) impact on sexuality and intimate relationship; however, the issue has received poor attention so far. We performed a systematic literature review in order to provide an up-to-date account of sexuality in ALS. References were identified by searches of PubMed, Web of Science, Scopus and PsycINFO (1970-2017, English literature). Read More

View Article
December 2018

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.

EMBO Rep 2018 Dec 11. Epub 2018 Dec 11.

Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London, UK

The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat estrogen-positive breast cancer. Here, we show that tamoxifen mechanically reprograms the tumor microenvironment through a newly identified GPER-mediated mechanism. Read More

View Article
December 2018
1 Read

Cardiac valve calcification and use of anticoagulants: Preliminary observation of a potentially modifiable risk factor.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

Aims: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. Read More

View Article
November 2018

A manual-based intervention for carers of people with dementia and sleep disturbances: an acceptability and feasibility RCT.

Health Technol Assess 2018 Dec;22(71):1-408

Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK.

Background: It has been estimated that between 25% and 40% of people living with dementia suffer from sleep disturbances, and there are currently no known effective treatments. Sleep disturbances may be the direct result of dementia or due to other comorbidities, such as pain and limited mobility. If carers' sleep is also disturbed, carers too can become tired and stressed, and this sometimes results in the breakdown of care in the home. Read More

View Article
December 2018

Tel-eVax: a genetic vaccine targeting telomerase for treatment of canine lymphoma.

J Transl Med 2018 Dec 11;16(1):349. Epub 2018 Dec 11.

BIOGEM Scarl, via Camporeale, 83031, Ariano Irpino, AV, Italy.

Background: we have recently shown that Tel-eVax, a genetic vaccine targeting dog telomerase (dTERT) and based on Adenovirus (Ad)/DNA Electro-Gene-Transfer (DNA-EGT) technology can induce strong immune response and increase overall survival (OS) of dogs affected by multicentric Diffuse Large B cell Lymphoma (DLBCL) when combined to COP therapy in a double-arm study. Here, we have utilized a clinically validated device for veterinary electroporation called Vet-ePorator™, based on Cliniporator™ technology currently utilized and approved in Europe for electrochemotherapy applications and adapted to electrogenetransfer (EGT).

Methods: 17 dogs affected by DLBCL were vaccinated using two Ad vector injections (Prime phase) followed by DNA-EGT (Boost phase) by means of a Vet-ePorator™ device and treated in the same time with a 27-week Madison Wisconsin CHOP protocol. Read More

View Article
December 2018

Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy.

Nat Commun 2018 12 6;9(1):5229. Epub 2018 Dec 6.

Center for Sleep Science and Medicine, Stanford University, Stanford, 94304, CA, USA.

Analysis of sleep for the diagnosis of sleep disorders such as Type-1 Narcolepsy (T1N) currently requires visual inspection of polysomnography records by trained scoring technicians. Here, we used neural networks in approximately 3,000 normal and abnormal sleep recordings to automate sleep stage scoring, producing a hypnodensity graph-a probability distribution conveying more information than classical hypnograms. Accuracy of sleep stage scoring was validated in 70 subjects assessed by six scorers. Read More

View Article
December 2018

Six-year outcome for children with ODD or CD treated with the coping power program.

Psychiatry Res 2018 Dec 4;271:454-458. Epub 2018 Dec 4.

The University of Alabama, Tuscaloosa, AL USA.

Children with severe aggressive behavioral problems are one of the groups most frequently referred to mental health clinics, and they engage in behaviors that put them at risk for substance use problems and a host of other negative outcomes. The present study aimed to assess the long-term outcome (six-year follow up) of the Coping Power Program delivered in a mental health hospital for children with behavioral disorders. We recruited one hundred and twenty children (mean age = 9. Read More

View Article
December 2018

1-2-3 Project: A Quality Improvement Initiative to Normalize and Systematize Palliative Care for All Patients With Cancer in the Outpatient Clinic Setting.

J Oncol Pract 2018 Dec;14(12):e775-e785

Memorial Sloan Kettering Cancer Center, New York, NY.

Background:: Prior work to integrate early palliative care in oncology has focused on patients with advanced cancer and primarily on palliative care consultation. We developed this outpatient clinic initiative for newly diagnosed patients at any stage, emphasizing primary (nonspecialist) palliative care by oncology teams, with enhanced access to palliative care specialists.

Methods:: We piloted the project in two medical oncology specialty clinics (for patients with myelodysplastic syndrome and GI cancer, respectively) to establish feasibility. Read More

View Article
December 2018

Lessons From Reporting National Performance Measures in a Regional Setting: Washington State Community Cancer Care Report.

J Oncol Pract 2018 Dec;14(12):e801-e814

Fred Hutchinson Cancer Research Center, Seattle, WA; Premera Blue Cross, Mountlake Terrace, WA; and University of Washington School of Medicine, Seattle, WA.

Regional public reporting of performance measures in oncology can facilitate local decision making across stakeholders, but small numbers of patients and clinics pose a challenge to creating statistically robust measures. In this article, we describe our development of the Community Cancer Care in Washington State: Quality and Cost Report, the first publicly available report showing clinic-level quality and cost measures at the regional level. We learned key lessons in how to adapt national performance reporting to our regional setting using a registry-linked multipayer claims database. Read More

View Article
December 2018
2 Reads

Simultaneous Co-segmentation of Tumors in PET-CT Images Using Deep Fully Convolutional Networks.

Med Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Electrical and Computer Engineering, the University of Iowa.

Purpose: To investigate the use and efficiency of 3-D deep learning, fully convolutional networks (DFCN) for simultaneous tumor co-segmentation on dual-modality non-small cell lung cancer (NSCLC) PET-CT images.

Methods: We used DFCN co-segmentation for NSCLC tumors in PET-CT images, considering both the CT and PET information. The proposed DFCN-based co-segmentation method consists of two coupled 3D-UNets with an encoder-decoder architecture, which can communicate with the other in order to share complementary information between PET and CT. Read More

View Article
December 2018
1 Read

Adult type rhabdomyoma presenting as a parathyroid adenoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Adult-type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region.

Methods: At our institution, we encountered a patient who was diagnosed clinically with parathyroid adenoma based on signs and symptoms of hyperparathyroidism and suggestive radiologic findings. Read More

View Article
December 2018

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

View Article
December 2018
2 Reads

Six-minute screening test can provide valid information about the skills that underlie childhood reading and cognitive abilities.

Acta Paediatr 2018 Dec 9. Epub 2018 Dec 9.

Educational Neuroimaging Center, Faculty of Education in Science and Technology, Technion, Haifa, Israel.

Aim: Reading difficulties can have complex origins and diagnostic measures can be expensive and time consuming. We tested Zippy6, a six-minute screening test that we developed, to see how it compared with a battery of established screening tools.

Methods: This study was carried out at Cincinnati Children's Hospital Medical Center, USA, from 2014-2016. Read More

View Article
December 2018

Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403).

Adv Healthc Mater 2018 Dec 10:e1801233. Epub 2018 Dec 10.

Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040, Regensburg, Germany.

The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti-Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background-free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Read More

View Article
December 2018
4.880 Impact Factor

Physiological in vitro sacroiliac joint motion: a study on three-dimensional posterior pelvic ring kinematics.

J Anat 2018 Dec 9. Epub 2018 Dec 9.

Fraunhofer Institute for Machine Tools and Forming Technology IWU, Dresden, Germany.

The sacroiliac joint (SIJ) is a well-known source of low back and pelvic pain, of increasing interest for both conservative and surgical treatment. Alterations in the kinematics of the pelvis have been hypothesized as a major cause of SIJ-related pain. However, definitions of both the range and the extent of physiological movement are controversial, and there are no clear baseline data for pathological alterations. Read More

View Article
December 2018

Transradial versus transfemoral percutaneous coronary intervention of left main disease: A systematic review and meta-analysis of observational studies.

Catheter Cardiovasc Interv 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine Division of Cardiology, North Shore University Hospital, Hofstra Northwell School of Medicine, New York.

Objectives: To assess the efficacy and safety of transradial (TR) versus transfemoral (TF) percutaneous coronary intervention (PCI) in left main (LM) lesion.

Background: TR-PCI is the preferred approach compared with TF approach because of less bleeding risk. LM-PCI is often challenging because of the anatomical complexity and uniqueness of supplying a large myocardium territory. Read More

View Article
December 2018
1 Read

Quality, bioactivity study, and preclinical acute toxicity, safety pharmacology evaluation of PEGylated recombinant human endostatin (M ES).

J Biochem Mol Toxicol 2018 Dec 10:e22257. Epub 2018 Dec 10.

National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China.

Endostar, a potent endogenous antiangiogenic factor, is wildly used in clinics. However, it was easily degraded by enzymes and rapidly cleared by the kidneys. To overcome these shortcomings, PEGylated recombinant human endostatin was developed. Read More

View Article
December 2018

Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Spontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.

Objective: To determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.

Animals: Two hundred one client-owned dogs with spontaneous hypercortisolism. Read More

View Article
December 2018

Cross-infection control in clinical training: Development of a device for storing a composite resin in restorative dentistry.

Microsc Res Tech 2018 Oct;81(10):1087-1094

Department of Social Dentistry, Araraquara School of Dentistry, University of Sao Paulo State, São Paulo, Brazil.

This study presented a biosafety device for the hygienic storage of composite resin during restorative procedures in teaching clinics, RESTAURASAFE, and to compare the color stability, surface hardness, and degree of conversion of the composite resin made with the proposed device to those of conventionally made resins. Esthet-X HD composite was manipulated directly from the syringe, fractionated doses, dappen dish or RESTAURASAFE. Disc-shaped specimens were immersed in artificial saliva and coffee for 60 days and the color stability and the Vickers surface hardness were evaluated during 60 days. Read More

View Article
October 2018