123,958 results match your criteria Clinics in Plastic Surgery[Journal]


[Subjective memory impairments in early detection of dementia: Relation to acceptability of lumbar puncture in memory clinic patients].

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Vitos Klinikum Gießen-Marburg, Vitos Klinik für Psychiatrie und Psychotherapie Gießen; Fachbereich Medizin, Philipps-Universität Marburg.

Background: In memory clinics, biomarker-based diagnostic tools for early detection and differential diagnosis of dementia are increasingly important, even if their acceptance by patients is relatively low.

Objective: The aim of study was to examine whether sociodemographic and clinical features of memory clinic patients are associated with acceptance of lumbar puncture (LP). Of particular interest was the patients' self-perception of memory decline (subjective memory impairment, SMI) accompanied by related concerns that might affect decision to consent to LP. Read More

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December 2018

Self-compassion and depression, anxiety, and resilience in adults with epilepsy.

Epilepsy Behav 2018 Dec 14;90:154-161. Epub 2018 Dec 14.

Division of Health Research, Faculty of Health and Medicine, Furness College, Lancaster University, Lancaster LA1 4YG, UK. Electronic address:

Background: Research suggests that people with epilepsy (PWE) are more likely to experience depression and anxiety than the general population. Given the adversity associated with the condition, resilience may also be important. However, to date, resilience has been largely overlooked in the epilepsy literature. Read More

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December 2018

Association between Serum Resistin, Adiposity Measures and Inflammatory Makers in Women Without Cardiovascular Diseases.

Chem Phys Lipids 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Aims: The convergence of obesity and inflammation in the pathogenesis of cardiovascular diseases (CVD) has been recognized over the past decade. Resistin has emerged as a novel secreted protein with links to both insulin resistance and inflammation. We aimed to investigate the relationship between changes in serum resistin levels with metabolic parameters, including obesity and inflammatory markers in women free of CVD. Read More

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December 2018

Mediastinoscopy for staging of Non-Small Cell Lung Cancer: surgical performance in the Netherlands.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Northwest Clinics, Alkmaar, the Netherlands.

Background: To determine optimal treatment options in non-small cell lung cancer (NSCLC), accurate staging of the mediastinal lymph nodes is of great importance. In case of suspected mediastinal metastases, EUS/EBUS combined with mediastinoscopy is the gold standard. Diagnostic value of these procedures stands or falls by how they are technically performed. Read More

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December 2018

Investigation of the association between the interval from internal teat sealant administration to calving and early-lactation clinical mastitis in New Zealand dairy heifers.

N Z Vet J 2018 Dec 17:1-20. Epub 2018 Dec 17.

b Veterinary Centre Limited , Oamaru, 311 Thames Street, Oamaru 9400 , New Zealand.

Aim: To examine the association between the interval from internal teat sealant (ITS) administration to calving and the incidence of farmer-recorded clinical mastitis in the first 30 days of lactation in pasture-based dairy heifers.

Methods: Heifers that were administered an ITS by a single veterinary business in the South Island of New Zealand over the winter of 2014 were enrolled in a cross-sectional observational study. ITS was administered to all heifers on each participating farm on a single calendar day. Read More

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December 2018

Hippotherapy in Rehabilitation Care for Children With Neurological Impairments and Developmental Delays: A Case Series.

Pediatr Phys Ther 2019 Jan;31(1):E14-E21

Department of Developmental Rehabilitation (Ms Kraft) and Children's Minnesota Research Institute (Drs Finch and Barnes and Mss Nickel and Griffin), Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota; Hold Your Horses (Ms Weisberg), Maple Plain, Minnesota.

Purpose: This report assesses functional mobility in children with neurological impairments and documented gross motor delays, before and after receiving either hippotherapy or standard outpatient physical therapy (PT).

Summary Of Key Points: This is a case-series report using data previously collected for a discontinued randomized controlled trial, in which participants received hippotherapy or standard outpatient clinic PT for a 12-week treatment period. Results demonstrated both subjective and objective functional mobility improvements after treatment in participants receiving hippotherapy and standard outpatient PT, as determined by the Peabody Developmental Motor Scales-2, the Pediatric Evaluation of Disability Inventory, and the Goal Attainment Scaling. Read More

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January 2019

ABT-737 and erufosine combination against castration-resistant prostate cancer: a promising but cell-type specific response associated with the modulation of anti-apoptotic signaling.

Anticancer Drugs 2018 Dec 14. Epub 2018 Dec 14.

Toxicology and Chemotherapy Unit, German Cancer Research Center, Heidelberg, Germany.

A deeper understanding of the molecular basis of castration-resistant prostate cancer (CRPC) paved the way for the rational design and development of targeted therapies, which yielded promising preclinical results. However, translation of these potentially promising agents into clinics has usually failed, partly because of tumor heterogeneity. In this study, anticancer activities of the Bcl-2 inhibitor ABT-737 and the Akt-inhibitor erufosine (ErPC3) alone and in combination were compared between CRPC (PC-3 and DU-145) and healthy (PNT-1A) cell lines. Read More

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December 2018

Dancing Dorsal Quadrilaterals: A Novel Peripherally Induced Movement Disorder.

JAMA Neurol 2018 Dec 17. Epub 2018 Dec 17.

The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Importance: Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias.

Objective: To introduce and characterize the dancing dorsal quadrilaterals, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation.

Design, Setting, And Participants: Between 1990 and 2015, a total of 4 patients who developed abnormal movements of the dorsal quadrilateral muscles after upper spine instrumentation were referred to movement disorders clinics at 3 academic medical centers in the United States, Canada, and Argentina. Read More

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December 2018
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Cortisol levels among older people with and without depression and dementia.

Int Psychogeriatr 2018 Dec 17:1-5. Epub 2018 Dec 17.

Norwegian National Advisory Unit on Ageing and Health,Vestfold Hospital Trust,Tønsberg,Norway.

ABSTRACTCortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 older people, from the community (home and nursing homes) and specialized care (memory clinics and old age psychiatry wards), mean age 76. Read More

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December 2018

Pilot RCT of a social media parenting intervention for postpartum mothers with depression symptoms.

J Reprod Infant Psychol 2018 Dec 17:1-12. Epub 2018 Dec 17.

b Policylab: Center to Bridge Research Practice, & Policy , The Children's Hospital of Philadelphia, Roberts Center for Pediatric Research , Philadelphia , PA , USA.

Objective: This pilot study describes the adaptation of a parenting group intervention for social media, and examines the feasibility, acceptability and initial outcomes of the adapted intervention for mothers with postpartum depression symptoms.

Background: Postpartum depression can negatively affect parenting and the parent-infant relationship. Mothers with postpartum depression symptoms experience barriers to access in-person parenting interventions. Read More

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December 2018

Tissue Engineering for the Temporomandibular Joint.

Adv Healthc Mater 2018 Dec 17:e1801236. Epub 2018 Dec 17.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA.

Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Read More

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December 2018

Electrophysiology as a theoretical and methodological hub for the neural sciences.

Authors:
James F Cavanagh

Psychophysiology 2018 Dec 16:e13314. Epub 2018 Dec 16.

Department of Psychology, University of New Mexico, Albuquerque, New Mexico.

Electrophysiology is a direct measure of neuronal processes, and it is uniquely sensitive to canonical neural operations that underlie emergent psychological operations. These qualities make it well suited for discovery of aberrant neural mechanisms that underlie complicated disease states. This technique is routinely utilized in vitro, in vivo, and in outpatient neurological clinics, offering a translatable bridge between animal models and human patients. Read More

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December 2018

Caregiver burden and quality of life two years after attendance at a memory clinic.

Int J Geriatr Psychiatry 2018 Dec 17. Epub 2018 Dec 17.

Department of Health Services Research & Policy, London School of Hygiene & Tropical Medicine, London, UK.

Objectives: We aimed to describe 1) the burden and HRQL of informal caregivers of new patients attending a memory assessment service (MAS), 2) changes in these outcomes over two years and 3) satisfaction with services.

Methods: Informal caregivers of patients attending one of 73 MASs throughout England completed questionnaires at the patient's first appointment, and 6 and 12 months later. Participants from 30 of these MASs were also followed up at 24 months. Read More

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December 2018

Characteristics of single ocular motor nerve palsy associated with anti-GQ1b antibody.

J Neurol 2018 Dec 17. Epub 2018 Dec 17.

Research Administration Team, Seoul National University Bundang Hospital, Seongnam, South Korea.

To define the prevalence and characteristics of single ocular motor nerve palsy (OMNP) associated with positive serum anti-GQ1b antibody. We performed a prospective multicenter study that recruited 82 patients with single OMNP without identifiable causes from the history and neuroimaging in six neurology clinics of university hospitals. We measured serum anti-GQ1b antibody in all participants. Read More

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December 2018

A limited market: the recruitment of gay men as surrogacy clients by the infertility industry in the USA.

Authors:
Heather Jacobson

Reprod Biomed Soc Online 2018 Nov 18;7:14-23. Epub 2018 Nov 18.

Department of Sociology and Anthropology, The University of Texas at Arlington, Arlington, TX, USA.

Gestational surrogacy via egg donation is an expensive - and sometimes ambivalently undertaken - but increasingly popular route to planned fatherhood for some gay men. The surrogacy market in the USA plays an important role for gay men with the financial resources to access these services, as it is currently the only stable, commercial market in which there are legal protections for openly gay men. While a small, ethnographic and qualitative literature on the experiences of gay fathers via surrogacy exists, less is known about the state of the surrogacy industry towards gay men as clients. Read More

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November 2018

Reducing inappropriate antibiotic prescribing in upper respiratory tract infection in a primary care setting in Kolkata, India.

Authors:
Amy Dehn Lunn

BMJ Open Qual 2018 20;7(4):e000217. Epub 2018 Nov 20.

Calcutta Rescue, Kolkata, India.

Inappropriate antibiotic use is a key factor in the emergence of antibiotic resistance. The majority of antibiotics are prescribed in primary care, where upper respiratory tract infection (URTI) is a common presentation. Inappropriate antibiotic prescribing in URTI is common globally and has increased markedly in developing and transitional countries. Read More

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November 2018

The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials.

World Allergy Organ J 2018 6;11(1):34. Epub 2018 Dec 6.

1Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.

Background: The severe forms of asthma represent a major burden, because of severity of symptoms, costs and impact on everyday life. Recently, Mepolizumab (MEP) was approved and marketed for the treatment of hypereosinophilic severe asthma. This anti-IL-5 monoclonal antibody reduced exacerbation rates and oral corticosteroid (OCS) use in well selected patients. Read More

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December 2018

Improving psychotherapies offered in public hospitals in Nairobi, Kenya: extending practice-based research model for LMICs.

Int J Ment Health Syst 2018 11;12:76. Epub 2018 Dec 11.

3Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.

Background: Psychotherapy and mental health services in Nairobi's public hospitals are increasing. Rather than prematurely imposing psychotherapy protocols developed in Western countries to Kenya, we argue that first studying psychological interventions as they are practiced may generate understanding of which psychological problems are common, what interventions therapists use, and what seems to be effective in reducing psychiatric problems in a lower and middle income country like Kenya.

Method: We present preliminary findings from a process-outcome study involving 345 patients from two public institutions, Kenyatta National and Mathare National Hospitals. Read More

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December 2018

Regional differences in the risk of insomnia symptoms among patients from general hospital outpatient clinics.

Neuropsychiatr Dis Treat 2018 30;14:3307-3315. Epub 2018 Nov 30.

The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China,

Background: Region-specific differences in the prevalence of insomnia symptoms in outpatient clinics in China have received little systematic study. This study was conducted preliminarily to examine region-specific differences in the risk of insomnia symptoms in Chinese outpatients.

Method: In total, 4,399 adult outpatients (urban vs rural residents: 1,768 vs 2,631) who completed three questions focusing on insomnia symptoms were included. Read More

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November 2018

Safety of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-1-infected adults with end-stage renal disease on chronic haemodialysis: an open-label, single-arm, multicentre, phase 3b trial.

Lancet HIV 2018 Dec 13. Epub 2018 Dec 13.

Department of HIV Clinical Research, Gilead Sciences, Foster City, CA, USA. Electronic address:

Background: Current treatment for HIV-infected individuals with renal failure on haemodialysis frequently requires complex regimens with multiple pills. A daily single-tablet regimen of coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide is approved in Europe, the USA, and in other regions for use in HIV-1-infected individuals with mild-to-moderate chronic kidney disease (creatinine clearance 30-69 mL/min). We aimed to assess the safety, efficacy, and pharmacokinetics of this regimen in HIV-infected adults with end-stage renal disease on chronic haemodialysis. Read More

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December 2018

Repeatability of measuring knee flexion angles with wearable inertial sensors.

Knee 2018 Dec 13. Epub 2018 Dec 13.

Lawson Health Research Institute, Robarts Research Institute, Department of Medical Biophysics, Department of Surgery, Western University, London, ON, Canada.

Background: As assessment with inertial-measurement-units (IMUs) increases in research and in clinics, it is important to be aware of the repeatability of these sensors. The objectives of this experiment were to evaluate the measurement repeatability of IMU joint angles using a repeatable robot controller and an anthropomorphic leg phantom and to determine effects of joint speed and sensor positioning on the angles collected by these sensors. Comparisons to an electro-goniometer and three-dimensional (3D) motion capture cameras were also completed. Read More

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December 2018

Leptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depression.

Eur Neuropsychopharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Weight gain is a common adverse effect of lithium augmentation. Previous studies indicate an impact of genetic variants at the leptin gene on weight gain as a consequence of psychopharmacological treatment. The primary aim of our study was to identify variants at the leptin locus that might predict lithium-induced weight gain. Read More

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December 2018

Changing face of orofacial pain: The diagnostic impact of working with Neurology on an orofacial pain clinic.

Int J Oral Maxillofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Oral Surgery, King's College London Dental Institute, London, United Kingdom. Electronic address:

This study assessed the impact of collaborative working with a headache neurologist on diagnoses of patients attending orofacial pain (OFP) clinic. Patient diagnostic data was collected from adult patients attending an Orofacial Pain Service from January 2013 to January 2017. A liaison headache neurologist was appointed late 2015; OFP clinics were co-run with the neurologist specialist thereafter. Read More

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December 2018

Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label, randomised, controlled trial.

Lancet Glob Health 2019 Jan;7(1):e119-e131

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Electronic address:

Background: In southeast Asia, antibiotic prescription in febrile patients attending primary care is common, and a probable contributor to the high burden of antimicrobial resistance. The objective of this trial was to explore whether C-reactive protein (CRP) testing at point of care could rationalise antibiotic prescription in primary care, comparing two proposed thresholds to classify CRP concentrations as low or high to guide antibiotic treatment.

Methods: We did a multicentre, open-label, randomised, controlled trial in participants aged at least 1 year with a documented fever or a chief complaint of fever (regardless of previous antibiotic intake and comorbidities other than malignancies) recruited from six public primary care units in Thailand and three primary care clinics and one outpatient department in Myanmar. Read More

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January 2019

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Authors:
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal Andrew Lee Jonathan P Tyrer Ting-Huei Chen Qin Wang Manjeet K Bolla Xin Yang Muriel A Adank Thomas Ahearn Kristiina Aittomäki Jamie Allen Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Volker Arndt Kristan J Aronson Paul L Auer Päivi Auvinen Myrto Barrdahl Laura E Beane Freeman Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam Brentnall Ian W Brock Angela Brooks-Wilson Sara Y Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D Carter Jose E Castelao Stephen J Chanock Rowan Chlebowski Hans Christiansen Christine L Clarke J Margriet Collée Emilie Cordina-Duverger Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana M Eccles Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Jonine Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago-Dominguez Susan M Gapstur José A García-Sáenz Mia M Gaudet Vassilios Georgoulias Graham G Giles Irina R Gilyazova Gord Glendon Mark S Goldberg David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Susan E Hankinson Elaine F Harkness Steven N Hart Wei He Alexander Hein Jane Heyworth Peter Hillemanns Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Milena Jakimovska Anna Jakubowska Wolfgang Janni Esther M John Nichola Johnson Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Katarzyna Kaczmarek Vesa Kataja Renske Keeman Michael J Kerin Elza Khusnutdinova Johanna I Kiiski Julia A Knight Yon-Dschun Ko Veli-Matti Kosma Stella Koutros Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Jenna Lilyquist Annika Lindblom Sara Lindström Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jirong Long Jan Lubiński Michael P Lux Robert J MacInnis Tom Maishman Enes Makalic Ivana Maleva Kostovska Arto Mannermaa Siranoush Manoukian Sara Margolin John W M Martens Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Usha Menon Pooja Middha Nicola Miller Fernando Moreno Anna Marie Mulligan Claire Mulot Victor M Muñoz-Garzon Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Kenneth Offit Janet E Olson Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Julian Peto Mila Pinchev Dijana Plaseska-Karanfilska Eric C Polley Ross Prentice Nadege Presneau Darya Prokofyeva Kristen Purrington Katri Pylkäs Brigitte Rack Paolo Radice Rohini Rau-Murthy Gad Rennert Hedy S Rennert Valerie Rhenius Mark Robson Atocha Romero Kathryn J Ruddy Matthias Ruebner Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Peter Schürmann Lukas Schwentner Christopher Scott Rodney J Scott Caroline Seynaeve Mitul Shah Mark E Sherman Martha J Shrubsole Xiao-Ou Shu Susan Slager Ann Smeets Christof Sohn Penny Soucy Melissa C Southey John J Spinelli Christa Stegmaier Jennifer Stone Anthony J Swerdlow Rulla M Tamimi William J Tapper Jack A Taylor Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Thérèse Truong Maria Tzardi Hans-Ulrich Ulmer Michael Untch Celine M Vachon Elke M van Veen Joseph Vijai Clarice R Weinberg Camilla Wendt Alice S Whittemore Hans Wildiers Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Yan Zhang Wei Zheng Argyrios Ziogas Alison M Dunning Deborah J Thompson Georgia Chenevix-Trench Jenny Chang-Claude Marjanka K Schmidt Per Hall Roger L Milne Paul D P Pharoah Antonis C Antoniou Nilanjan Chatterjee Peter Kraft Montserrat García-Closas Jacques Simard Douglas F Easton

Am J Hum Genet 2018 Dec 5. Epub 2018 Dec 5.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Read More

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December 2018
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The diagnostic role of triple endoscopy in pediatric patients with chronic cough.

Int J Pediatr Otorhinolaryngol 2019 Jan 13;116:58-61. Epub 2018 Oct 13.

Pediatric Department Massachusetts Eye and Ear Infirmary, Airway and Swallowing Center Massachusetts Eye and Ear Infirmary, United States.

Objective/hypothesis: Multi-disciplinary aero-digestive centers provide high quality health care through improved outcomes and treatment costs over separate sub specialty clinics. These outcomes are often the result of a common investigative tool known as triple endoscopy: a rigid bronchoscopy performed by an otolaryngologist, flexible bronchoscopy and lavage obtained by a pulmonologist, and an endoscopy with guided biopsies performed by a gastroenterologist. Combining such procedures into one 'triple endoscopy' allows for diagnoses which otherwise might have been missed with just one procedure. Read More

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January 2019

Parent perspectives on multidisciplinary pediatric hearing healthcare.

Int J Pediatr Otorhinolaryngol 2019 Jan 31;116:141-146. Epub 2018 Oct 31.

The Ohio State Wexner Medical Center, College of Medicine, Department of Otolaryngology - Head & Neck Surgery, OSU Eye and Ear Institute, 915 Olentangy River Road, Columbus, OH, 43212, USA; Nationwide Children's Hospital- Pediatric Otology & Hearing Program, 700 Children's Drive, Suite 2A, Columbus, OH, 43205, USA.

Introduction: Family-centered healthcare demands that families provide input regarding the care of their children. Very little is known, however, about how families perceive their experience in different types of multidisciplinary team models, and specifically, in the multidisciplinary setting currently utilized in many pediatric hearing clinics.

Methods: Quantitative and qualitative parent survey responses were collected and analyzed in a tertiary care pediatric medical center after a one-day multidisciplinary assessment clinical appointment. Read More

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January 2019

"But doctor, I googled it!": The "three Rs" of managing patients in the age of information overload.

Clin Dermatol 2019 Jan - Feb;37(1):74-77. Epub 2018 Aug 10.

Department of Neurology, Stanford University Hospitals and Clinics, Palo Alto, California, USA.

Managing patient interactions in the age of the Internet can be particularly difficult due to the vast amount of information available. Dermatologists should be able to identify relevant patient concerns to adequately address them. We discuss the ethical issues involved in interacting with patients who use the Internet for medical knowledge, and we suggest a method, using the "three Rs" (reassure, redirect, refer), to conduct these interactions. Read More

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Religiosity and Beliefs About the Transmission of Cancer, Chemotherapy, and Radiation Through Physical Contact in Saudi Arabia.

J Relig Health 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry, King Abdulaziz University, Jeddah, Saudi Arabia.

We examined relationships between religiosity and Saudi cancer patients' beliefs about the spread of cancer, chemotherapy, and radiation therapy through close physical contact. Surveyed were 64 patients seen in university oncology clinics. Assessed were beliefs about the spread of cancer and its treatments, along with religious, demographic, social, psychological, and cancer-related characteristics. Read More

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December 2018

Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease.

Nephron 2018 Dec 14:1-9. Epub 2018 Dec 14.

Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.

Background/aims: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). Read More

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December 2018

Clinical Exome Sequencing unravels new disease-causing mutations in the myeloproliferative neoplasms: A pilot study in patients from the state of Qatar.

Gene 2018 Dec 13. Epub 2018 Dec 13.

National Center for Cancer Care and Research (NCCCR), HMC, Doha, Qatar.

Clinical Exome Sequencing (CES) has increasingly become a popular diagnostic tool in patients suffering from genetic disorders that are clinically and genetically complicated. Myeloproliferative Neoplasms (MPNs) is an example of a heterogeneous disorder. In Qatar, familial cases of MPNs are more frequently seen than described in the literature. Read More

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December 2018
2.138 Impact Factor

A new complex rearrangement in infant ALL: t(X;11;17)(p11.2;q23;q12).

Cancer Genet 2018 Dec 28;228-229:110-114. Epub 2018 Oct 28.

Department of Pediatrics, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes 3900, Bairro Monte Alegre, Ribeirão Preto, SP CEP 14040-900, Brazil.

We present a case of an infant who developed pro-B acute lymphoblastic leukemia with a rare and complex MLL-translocation. Cytogenetic analysis of bone marrow cells at diagnosis showed a 46,XY,t(X;11)(p11.2;q23)[13]/46,XY[7] karyotype. Read More

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December 2018
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Regression of human immunodeficiency virus-associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Oral Pathology, Department of Stomatology, University of Sao Paulo School of Dentistry, Sao Paulo, Brazil.

Background: Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.

Methods: We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution. Read More

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December 2018
1 Read

Non-adherence to psychotropic medication assessed by plasma levels in newly admitted psychiatric patients.

Psychiatry Clin Neurosci 2018 Dec 15. Epub 2018 Dec 15.

Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of experimental Psychiatry and Psychotherapy, Austria.

Aims: Non-adherence or partial adherence to psychotropic medication is found in 18-70% of patients. However, many previously used methods for the assessment of adherence (e.g. Read More

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December 2018

The Impact of the Patient-Centered Medical Home on Asthma-Related Visits to the Emergency Room: A Fixed Effects Regression Approach.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Policy and Administration, Pennsylvania State University, 601A Donald H. Ford Building, University Park, PA, 16802, USA.

Objective To estimate the effect of a patient-centered medical home (PCMH) intervention on asthma-related emergency room (ER) visits of pediatric patients. Methods Patients receiving care at pediatric primary care practices participating in the Florida Pediatric Medical Home Demonstration Project as well as pediatric patients treated at non-participating clinics were identified from 4 years of claims and enrollment data. We estimate several fixed effects logistic regression models using one pre-treatment year and three post-treatment years to investigate whether asthma-related ER visits decreased because of the PCMH intervention. Read More

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December 2018
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Strongyloides stercoralis infection in imported and local dogs in Switzerland: from clinics to molecular genetics.

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

Small Animal Clinic, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Strongyloides stercoralis is a worldwide-distributed intestinal nematode affecting mainly humans and dogs. Canine strongyloidosis is generally characterised by diarrhoea, malabsorption and bronchopneumonia, and may be fatal in cases of impaired immunity. In recent years, molecular and epidemiological studies suggested that host-adapted populations of S. Read More

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December 2018

Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

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December 2018
1 Read

Reasons to stop drinking alcohol among patients with rheumatoid arthritis in Sweden: a mixed-methods study.

BMJ Open 2018 Dec 14;8(12):e024367. Epub 2018 Dec 14.

Spenshult Research and Development Center, Spenshult, Halmstad, Sweden.

Objectives: The aims were to identify patients with rheumatoid arthritis (RA) who had stopped drinking alcohol and compare them with patients drinking alcohol, and to explore reasons for stopping drinking alcohol.

Design: A sequential explanatory mixed methods design was used.

Setting: Six rheumatology clinics in Southern Sweden Better Anti-Rheumatic FarmacOTherapy cohort. Read More

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December 2018

Obinutuzumab pretreatment abrogates tumor lysis risk while maintaining undetectable MRD for venetoclax + obinutuzumab in CLL.

Blood Adv 2018 Dec;2(24):3566-3571

Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

Early data on venetoclax-containing regimens for the treatment of chronic lymphocytic leukemia (CLL) show promising results with deep remissions, but are hampered by potential risk for tumor lysis syndrome (TLS). Whether optimal duration of venetoclax treatment can be guided by minimal residual disease (MRD) is currently unknown. To study whether TLS risk can be mitigated in an unfit population by introducing preinduction, and whether MRD-guided duration of venetoclax treatment is a feasible and efficacious approach, we performed the Dutch-Belgian Cooperative Trial Group for Hemato-oncology (HOVON) 139/GIVE trial. Read More

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December 2018

Redesigning primary care in the safety net: A qualitative analysis of team-based care implementation.

Healthc (Amst) 2018 Dec 11. Epub 2018 Dec 11.

University of California San Francisco, Center for Vulnerable Populations, Division of General Internal Medicine, United States.

Background: Team-based care is an innovative approach to primary care in which groups of health care professionals work collaboratively to manage care for groups of patients. Safety-net organizations face specific barriers to implementing health care innovations. More research is needed that documents the dynamics that inform implementation and sustainment of innovative practices in the safety net. Read More

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December 2018

Knee MRI Primary Care Ordering Practices for Nontraumatic Knee Pain: Compliance With ACR Appropriateness Criteria and Its Effect on Clinical Management.

J Am Coll Radiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia.

Purpose: To evaluate the appropriateness of MRI ordering practices and their effect on clinical management for nontraumatic knee pain at the primary care clinics of a large public urban hospital.

Materials And Methods: In all, 196 consecutive MRIs for nontraumatic knee pain ordered from primary care clinics in a large public urban hospital over an 18-month period were studied. ACR Appropriateness Criteria (AC) scores for nontraumatic knee pain were retrospectively calculated from medical record reviews. Read More

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December 2018

Toward an enhanced understanding of psychological resilience for HIV youth populations.

AIDS Care 2018 Dec 14:1-4. Epub 2018 Dec 14.

a SC SmartState Center for Healthcare Quality, Department of Health Promotion, Education, and Behavior, Arnold School of Public Health , University of South Carolina , Columbia , USA.

Though mother-to-child HIV transmission has been dramatically reduced in the past decade, there are currently an estimated 1.8 million children living with HIV across the globe, and over 30% of all new HIV infections occur among youth ages 15-25. While all youth experience developmental challenges, children and adolescents who are living with HIV must navigate these challenges within the context of high HIV stigma and must cope with a host of psychosocial and health-related challenges. Read More

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December 2018

Validity of a two-item screen for early psychosis.

Psychiatry Res 2018 Dec 3;270:861-868. Epub 2018 Nov 3.

Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA. Electronic address:

Well-validated screening tools have been developed to identify people at high risk for psychosis, but these are rarely used outside of specialty clinics or research settings. The development of extremely brief and simple screening tools could increase dissemination, especially in settings with low buy-in such as those with low base rates of psychosis and/or time constraints. We sought to identify such a brief measure by modeling participant responses to three psychosis screening questionnaires (Prime Screen; Prodromal Questionnaire-Brief; Youth Psychosis At Risk Questionnaire) in a sample of 139 help-seeking individuals and 335 college students (age range: 12-25). Read More

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December 2018
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Which patients initiate cognitive processing therapy and prolonged exposure in department of veterans affairs PTSD clinics?

J Anxiety Disord 2018 Nov 20;62:53-60. Epub 2018 Nov 20.

Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA; Department of Medicine, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA; Department of Psychiatry, University of Minnesota, 2450 Riverside Ave, Minneapolis, MN 55454, USA; Department of Psychology, University of Minnesota, 75 E River Rd, Minneapolis, MN 55455, USA. Electronic address:

The United States Department of Veterans Affairs (VA) provides Cognitive Processing Therapy (CPT) and Prolonged Exposure therapy (PE) for PTSD at all of its facilities, but little is known about systematic differences between patients who do and do not initiate these treatments. VA administrative data were analyzed for 6,251 veterans receiving psychotherapy over one year in posttraumatic stress disorder (PTSD) specialty clinics at nine VA medical centers. CPT and PE were initiated by 2,173 (35%) patients. Read More

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November 2018
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Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: inpatients and outpatients.

Int J Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children, including severe illness and fatality, in the Asia-Pacific Region since 1997. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200. Read More

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December 2018
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Access to Dermatology Services at Free Medical Clinics, A Nationwide Cross-sectional Survey.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Public and Preventative Health, Augusta University. Electronic address:

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December 2018
4 Reads

Enhancing smoking cessation in Mexico using an e-Health tool in primary healthcare.

Salud Publica Mex 2018 Sep-Oct;60(5):549-558

Department of Biomedical Research, Medical Center, Hackensack University. Hackensack, NJ, US.

Objective: To evaluate an e-Health tool designed to enhance smoking cessation in Mexico in primary healthcare.

Materials And Methods: Smokers 18 years of age and older were recruited in the waiting room of two primary healthcare clinics in Mexico City. Participants used an eHealth smoking cessation tool that included smoking-related assessments, education on pharmacotherapy, and motivational videos. Read More

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December 2017
2 Reads

High prevalence of binge drinking among people living with HIV in four African countries.

J Int AIDS Soc 2018 Dec;21(12):e25202

Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, Sénégal.

Introduction: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa.

Methods: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in Côte d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Read More

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December 2018
2 Reads

Dual Therapy Coating on Micro/Nanoscale Porous Polyetheretherketone to Eradicate Biofilms and Accelerate Bone Tissue Repair.

Macromol Biosci 2018 Dec 14:e1800376. Epub 2018 Dec 14.

School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.

Defective osteogenesis and latent infections continue to be two major issues in the therapy of bone tissue regeneration. In this study, a unique hierarchically micro/nanoscale-architecture is first proposed and produced on polyetheretherketone (PEEK). Besides, a "simvastatin-PLLA film-tobramycin microspheres" delivery system is subsequently fabricated to endow the PEEK implant with osteogenic and antibacterial capabilities. Read More

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December 2018

Validation of CollaboRATE and SURE - two short questionnaires to measure shared decision making during CPAP initiation.

J Sleep Res 2018 Dec 13:e12808. Epub 2018 Dec 13.

Department of Clinical Neurophysiology, Linköping University Hospital, Linköping, Sweden.

Adherence to continuous positive airway pressure (CPAP) treatment tends to be low. Brief validated instruments focusing on shared decision making have not been used in a CPAP context. The aim was to investigate factorial structure, categorical functioning of the response scale and differential item functioning across sub-populations of the CollaboRATE and Sure questionnaires among patients with obstructive sleep apnea (OSA) before CPAP treatment is initiated. Read More

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December 2018