125,338 results match your criteria Clinics Sao Paulo Brazil[Journal]


Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche.

Cells 2019 Feb 18;8(2). Epub 2019 Feb 18.

Department of Immunohematology and Blood Transfusion, L3-Q Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Expansion of hematopoietic stem cells (HSCs) for therapeutic purposes has been a "holy grail" in the field for many years. Ex vivo expansion of HSCs can help to overcome material shortage for transplantation purposes and genetic modification protocols. In this review, we summarize improved understanding in blood development, the effect of niche and conservative signaling pathways on HSCs in mice and humans, and also advances in ex vivo culturing protocols of human HSCs with cytokines or small molecule compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8020169DOI Listing
February 2019

The Effect of the Treatment at a Pain Clinic on the Patients' Assessment of Their Pain Intensity and the Incidence of Mental Disorders in the form of Anxiety, Depression, and Aggression.

Int J Environ Res Public Health 2019 Feb 18;16(4). Epub 2019 Feb 18.

Department of Anesthesiology and Intensive Care, John Paul II Western Hospital in Grodzisk Mazowiecki, 11 Daleka St., 05-825 Grodzisk Mazowiecki, Poland.

The aim of the study was to analyze the effect of the treatment given to patients in a pain clinic on their assessment of pain intensity and the incidence of emotional disturbances in the form of anxiety, depression, and aggression. The study was conducted from January 2014 to April 2018 among patients under the care of two Warsaw pain clinics. The study tools were the Hospital Anxiety and Depression Scale-Modified Version (HADS-M) and the Numerical Rating Scale (NRS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16040586DOI Listing
February 2019
1 Read

Use of Magnetic Resonance Imaging in Evaluating Fetal Brain and Abdomen Malformations during Pregnancy.

Medicina (Kaunas) 2019 Feb 17;55(2). Epub 2019 Feb 17.

Department of Radiology, Nuclear Medicine and Medical Physics, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, M. K. Čiurlionio g. 21, 03101 Vilnius, Lithuania.

Magnetic resonance imaging (MRI) is used as a clarifying technique after a high-resolution ultrasound examination during pregnancy. Combining ultrasound with MRI, additional diagnostic information is obtained or ultrasound diagnosis is frequently corrected. High spatial resolution provides accurate radiological imaging of internal organs and widens possibilities for detecting perinatal development disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020055DOI Listing
February 2019

Obstetric and gynaecology trainees' knowledge of paediatric and adolescent gynaecology services in the UK: A national qualitative thematic analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:30-35. Epub 2019 Feb 6.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Hills Road, West Midlands, Cambridge, United Kingdom.

Background: The British Society of Paediatric and Adolescent Gynaecology (BritSPAG) was created in 2000 with specific aims to include raising the profile of paediatric and adolescent gynaecology (PAG) within the United Kingdom (UK). The Society has since developed a set of clinical standards for all acute hospitals providing gynaecological services to enable successful provision of paediatric and adolescent gynaecology care.

Aims: To determine the depth of knowledge that obstetric and gynaecology trainees have with regards to the PAG services provided at their Hospital, reflecting how widely PAG services have had an impact on trainees. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.01.029DOI Listing
February 2019

Chlamydia trachomatis infection among patients attending sexual and reproductive health clinics: A cross-sectional study in Bao'an District, Shenzhen, China.

PLoS One 2019 19;14(2):e0212292. Epub 2019 Feb 19.

Shenzhen Baoan Center for Chronic Disease Control, Shenzhen, China.

This study aimed to estimate the prevalence of chlamydial trachomatis (CT) infection and explore its risk factors among patients attending sexual and reproductive health clinics in Shenzhen, China. We collected demographic and clinical information from attendees (aged 18-49). CT and Neisseria gonorrhoeae (NG) infection was determined by nucleic acid amplification test (NAAT) on self-collected urine specimens. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212292PLOS
February 2019

HLA-DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of coeliac disease: A multicentre study.

Int J Immunogenet 2019 Feb 19. Epub 2019 Feb 19.

Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.

Background And Purpose: Magnitude of gluten-specific T-cell responses in coeliac disease (CD) might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB1*02 allele dose on clinical outcomes.

Methods: We reviewed the charts of all coeliac patients attending to three Hungarian university clinics after 1997 and included those patients, who (a) were diagnosed with CD, (b) underwent high-resolution HLA typing and (c) were ≥18 years at the time of data collection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iji.12415DOI Listing
February 2019

Effect of patient education through a social network in young patients with type I diabetes in a Sub-Saharan context.

Pediatr Diabetes 2019 Feb 18. Epub 2019 Feb 18.

University of Yaounde.

Background: Patient education is essential in management of type I diabetes.

Objective: To evaluate the short-term impact of patient education through WhatsApp on the knowledge of the disease and glycemic control of adolescents and young adults living with Type 1 diabetes in a resource-limited setting.

Methods: A double arm non-randomized clinical trial was carried out in two clinics for diabetes in Cameroon, over a period of two months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pedi.12835DOI Listing
February 2019

Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Skin and Cancer Foundation Inc, Occupational Dermatology Research and Education Centre, Carlton, Victoria, Australia.

Background: Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer and has been reported to cause allergic contact dermatitis (ACD).

Objectives: To report our experience with contact allergy and ACD to lavender and to raise awareness of lavender as a potential contact allergen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13247DOI Listing
February 2019

Identifying EGFR mutations in lung adenocarcinoma by noninvasive imaging using radiomics features and random forest modeling.

Eur Radiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, No.241 Huaihai Road, Shanghai, 200030, China.

Objectives: The tyrosine kinase inhibitor (TKI)-sensitive mutations of the epidermal growth factor receptor (EGFR) gene is essential in the treatment of lung adenocarcinoma. To overcome the difficulty of EGFR gene test in situations where surgery and biopsy samples are too risky to obtain, we tried a noninvasive imaging method using radiomics features and random forest models.

Methods: Five hundred three lung adenocarcinoma patients who received surgery-based treatment were included in this study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00330-019-06024-y
Publisher Site
http://dx.doi.org/10.1007/s00330-019-06024-yDOI Listing
February 2019
1 Read

The Burden of Sarcoidosis Symptoms from a Patient Perspective.

Lung 2019 Feb 16. Epub 2019 Feb 16.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

Purpose: The clinical manifestations of sarcoidosis vary widely, depending on the intensity of the inflammation and the organ systems affected. Hence, sarcoidosis patients may suffer from a great variety of symptoms. The aim of this study was to compare the self-reported burden of sarcoidosis patients in Denmark, Germany and the Netherlands, especially the prevalence of fatigue and small fiber neuropathy (SFN)-related symptoms, as well as differences in treatment strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00408-019-00206-7DOI Listing
February 2019

Impact of a Novel Smartphone App (CureApp Smoking Cessation) on Nicotine Dependence: Prospective Single-Arm Interventional Pilot Study.

JMIR Mhealth Uhealth 2019 Feb 19;7(2):e12694. Epub 2019 Feb 19.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Background: Mobile apps have been considered to provide active and continuous support for smoking cessation. However, it is yet to be known whether a smoking cessation smartphone app improves long-term abstinence rates in nicotine-dependent patients.

Objective: This study aimed to evaluate the long-term abstinence effect of a novel smartphone app, CureApp Smoking Cessation (CASC), in patients with nicotine dependence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/12694DOI Listing
February 2019

The Early Psychosis Screener for Internet (EPSI)-SR: Predicting 12 month psychotic conversion using machine learning.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0810, USA. Electronic address:

Introduction: A faster and more accurate self-report screener for early psychosis is needed to promote early identification and intervention.

Methods: Self-report Likert-scale survey items were administered to individuals being screened with the Structured Interview for Psychosis-risk Syndromes (SIPS) and followed at eight early psychosis clinics. An a priori analytic plan included Spectral Clustering Analysis to reduce the item pool, followed by development of Support Vector Machine (SVM) classifiers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.schres.2019.01.015DOI Listing
February 2019
1 Read

[The Development of Medication and Psychotherapy from 1952 to 1957 in the Child and Adolescent Psychiatric Clinics Weissenau and Gütersloh].

Z Kinder Jugendpsychiatr Psychother 2019 Feb 19:1-10. Epub 2019 Feb 19.

1 ZfP Südwürttemberg, Akademisches Lehrkrankenhaus der Universität Ulm, Ravensburg.

The Development of Medication and Psychotherapy from 1952 to 1957 in the Child and Adolescent Psychiatric Clinics Weissenau and Gütersloh Abstract.

Objective: As a result of recent discussions concerning the misuse of medication in children in postwar Germany, the paper analyzes the treatment methods, especially psychopharmacotherapy, as well as therapeutic approaches employed in two German child and adolescent psychiatric hospitals (Weissenau and Guetersloh). We investigated the progression of prescription and the administration of psychotropic and experimental drugs between 1952 and 1957. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/1422-4917/a000646DOI Listing
February 2019

A program review of a community-based oral health care program for socially vulnerable and underserved citizens in Denmark.

Acta Odontol Scand 2019 Feb 19:1-7. Epub 2019 Feb 19.

b Department of Odontology, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen Ø , Denmark.

Objectives: To describe the oral health and oral health-related quality of life among social vulnerable adults enrolled in a special oral care program, and to evaluate the effect of oral care on their oral health-related quality of life.

Method: Social workers identified social vulnerable persons in social centres and referred them to the program. Dental clinics were arranged including a well-motivated staff to be special responsive to these clients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00016357.2019.1572921DOI Listing
February 2019

Health system organisation and patient pathways: breast care patients' trajectories and medical doctors' practice in Mali.

BMC Public Health 2019 Feb 18;19(1):204. Epub 2019 Feb 18.

Institute for Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Magdeburgerstraße 8, 06112, Halle (Saale), Germany.

Background: Information on pathways of women seeking diagnostic services due to breast- related symptoms can help highlight challenges related to the healthcare system in improving early diagnosis of breast cancer.

Methods: We retrospectively analysed the entire patient pathway, from first symptom recognition via initial healthcare visit up to final diagnosis at the pathology service in Mali. Data from questionnaire-based structured patient interviews (n = 124) were used to calculate time to first healthcare visit (median 91 days) and consecutive time to diagnosis (median 21 days) and to extract information on type of initially visited healthcare facility (community healthcare centre, referral hospital, tertiary hospital, private clinic). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-019-6532-8DOI Listing
February 2019

Evaluation of a human glycated hemoglobin test in canine diabetes mellitus.

J Vet Diagn Invest 2019 Feb 18:1040638719832071. Epub 2019 Feb 18.

Laboratory of Clinical Pathology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science, College of Veterinary Medicine (NY Kim, Y Kim, MC Kim, Ji, Hwang, Lee).

Glycated hemoglobin A1c (HbA1c) is widely used for monitoring and diagnosing human diabetes mellitus, but is rarely used in veterinary clinics. The goal of our study was to validate the commercial HbA1c testing system SD A1cCare analyzer (Bionote, Gyeoggi-do, South Korea) for use in dogs. Dogs were recruited with owner's consent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1040638719832071DOI Listing
February 2019

The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

Lupus 2019 Feb 18:961203319829825. Epub 2019 Feb 18.

2 Department of Rheumatology, State University of Rio de Janeiro, Brazil.

Objective: To analyze the impact of different classes of lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort of pregnant lupus patients.

Methods: This is a cohort study with retrospective and prospective data collection, conducted at the University Hospital of State University of Rio de Janeiro, Brazil, from 2011 to 2016. A total of 147 pregnancies of 137 systemic lupus erythematosus patients of whom 66 had lupus nephritis were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203319829825DOI Listing
February 2019

Ancillary service needs among persons new to HIV care and the relationship between needs and late presentation to care.

AIDS Care 2019 Feb 19:1-9. Epub 2019 Feb 19.

i Division of Infectious Diseases , University of Alabama at Birmingham (UAB) , Birmingham , AL , USA.

Ancillary service needs likely influence time to diagnosis and presentation for HIV care. The effect of both met and unmet needs on late presentation to HIV care is not well understood. We used baseline data from 348 people with HIV (PWH) with no prior HIV care who enrolled in iENGAGE (a randomized controlled trial (RCT) of an intervention to support retention in care) at one of four HIV clinics in the US. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09540121.2019.1576840DOI Listing
February 2019

Intra-arterial dantrolene for refractory cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, University of Missouri Hospital and Clinics, Columbia, Missouri, USA.

Background: Dantrolene has a safe side-effect profile and a mechanism of action that makes it attractive as an option for treatment of cerebral vasospasm. The authors report two cases of refractory cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage that were successfully treated with intra-arterial dantrolene.

Case Descriptions: Two patients, a 63-year-old woman and 36-year-old woman, developed severe vasospasm refractory to intra-arterial vasodilators after rupture of anterior communicating artery aneurysms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.239DOI Listing
February 2019

Post-operative Direct Healthcare Costs of Lumbar Discectomy are Reduced with the Use of a Novel Annular Closure Device in High-Risk Patients.

Spine J 2019 Feb 15. Epub 2019 Feb 15.

University of California, Davis. Sacramento, CA. Department of Neurological Surgery.

Background Context: Lumbar discectomy is a largely successful surgical procedure; however, reherniation rates in patients with large annular defects are as high as 27%. The expense associated with a revision surgery places significant burden on the healthcare system.

Purpose: To compare the direct healthcare costs through 5 years follow-up of conventional discectomy (Control) with those of discectomy supplemented by an adjunctive annular closure device (ACD) in high-risk patients with large annular defects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.spinee.2019.02.010DOI Listing
February 2019

Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Feb 18. Epub 2019 Feb 18.

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/humrep/dey393DOI Listing
February 2019

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health (DINOGMI), University of Genoa, Italy.

Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [18]F-FDG-PET.

Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-181022DOI Listing
February 2019

Distinctive Neurochemistry in Alzheimer's Disease via 7 T In Vivo Magnetic Resonance Spectroscopy.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

This study's objective was to increase understanding of biological mechanisms underlying clinical Alzheimer's disease (AD) by noninvasively measuring an expanded neurochemical profile and exploring how well this advanced technology distinguishes AD from cognitively normal controls. We measured concentrations of 14 neurochemicals using ultra-high field (7 T) ultra-short echo time (8 ms) magnetic resonance spectroscopy (MRS) in 16 participants with mild to moderate clinical AD and 33 age- and gender-matched control participants. MRS was localized to the posterior cingulate cortex (PCC), a region known to be impacted by AD, and the occipital cortex (OCC), a control region. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180861DOI Listing
February 2019

The Alz-tau Biomarker for Alzheimer's Disease: Study in a Caucasian Population.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Laboratory of Neuroscience, International Center for Biomedicine (ICC) and Faculty of Sciences, University of Chile, Santiago, Chile.

The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to control AD. A list of blood biomarkers has been reported but none has been validated for the Alzheimer's clinic. The changes in hyperphosphorylated tau and amyloid peptide in the cerebrospinal fluid is currently used as a tool in the clinics and for research purposes, but this method is highly invasive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180637DOI Listing
February 2019

Continued attendance for paediatric weight management: A multicentre, qualitative study of parents' reasons and facilitators.

Clin Obes 2019 Feb 18:e12304. Epub 2019 Feb 18.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Although prolonged engagement in paediatric weight management (PWM) is associated with positive treatment outcomes, little is currently known about enablers of long-term programme attendance. The purpose of our study was to explore families' reasons for and facilitators of their continued attendance at health services for PWM. Semi-structured, individual interviews were conducted with parents of children (10-17 year old; body mass index ≥85th percentile) who completed the active phase of treatment in one of four Canadian multidisciplinary clinics for PWM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cob.12304DOI Listing
February 2019

'We've made the best of it. But we do not have a normal life': families' experiences of tuberous sclerosis complex and seizure management.

J Intellect Disabil Res 2019 Feb 18. Epub 2019 Feb 18.

Guys and St Thomas' NHS Foundation Trust (Kings Health Partners), Evelina London Children's Hospital, London, UK.

Background: Tuberous sclerosis complex (TSC) is a complex multisystem genetic disorder. Approximately 84% of people with TSC have epilepsy. However, there is little literature available regarding families' experiences with TSC and seizure management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jir.12609DOI Listing
February 2019

Higher Physical Activity Is Associated With Less Fatigue and Insomnia Among Patients on Hemodialysis.

Kidney Int Rep 2019 Feb 1;4(2):285-292. Epub 2018 Nov 1.

Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.

Introduction: Patients on hemodialysis experience a heavy burden of symptoms that may be related to the low levels of physical activity reported in this population. We hypothesized that physical activity would be inversely related to symptom severity and that depression might mediate this association.

Methods: We designed a cross-sectional study of 48 patients receiving hemodialysis at 3 San Francisco dialysis clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365400PMC
February 2019

Cardiotrophin-1 and leptin as cardiovascular risk markers in male patients with obstructive sleep apnea syndrome.

Arch Med Sci Atheroscler Dis 2018 6;3:e123-e128. Epub 2018 Nov 6.

Clinics of Chest Diseases, Kayseri Education and Research Hospital, Kayseri, Turkey.

Introduction: Elevated cardiotrophin-1 (CT-1) and leptin levels are important risk factors for cardiovascular diseases (CVDs). Obstructive sleep apnea syndrome (OSAS) has also been reported to increase this risk. The aim of this study is to evaluate serum concentrations of CT-1 and leptin in patients with OSAS and whether there is a possible association between CT-1, leptin and OSAS severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.79407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374564PMC
November 2018

Utility of radius bone densitometry for the treatment of osteoporosis with once-weekly teriparatide therapy.

Osteoporos Sarcopenia 2018 Mar 5;4(1):29-32. Epub 2018 Mar 5.

Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Japan.

Objectives: As clinics that treat patients with osteoporosis do not usually have central dual-energy X-ray absorptiometry (DXA), bone density is often measured with radial DXA. However, no long-term evidence exists for radius bone density outcomes following treatment with once-weekly teriparatide in actual medical treatment.

Methods: We evaluated changes in bone density at 6-, 12-, and 18-month intervals using radial DXA in patients treated with once-weekly teriparatide for more than 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.afos.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362952PMC

Optical coherence tomography angiography for the anterior segment.

Eye Vis (Lond) 2019 1;6. Epub 2019 Feb 1.

1Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.

Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40662-019-0129-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357412PMC
February 2019

Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm SAMBA Study.

Biomed Res Int 2019 16;2019:5476350. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), School of Medical Sciences, Campinas, SP, Brazil.

Background: Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/5476350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354138PMC
January 2019

Targeting the third '90': introducing the viral load champion.

Public Health Action 2018 Dec;8(4):225-231

Centre for Aids Program of Research, University of Kwa Zulu-Natal, Durban, South Africa.

To move closer to achieving the third target of the UNAIDS 90-90-90 goals, we prospectively implemented a viral load (VL) champion (VLC) program aimed at enhancing VL monitoring and recognition of treatment failure. Three clinics in eThekwini, Kwa-Zulu Natal (low-, medium- and high-volume, encompassing 9184 patients overall) were each assigned a VLC. We employed a descriptive analysis (chart audit) to compare the pre-intervention period to a 1-year post-intervention period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/pha.18.0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361489PMC
December 2018

Scaling up isoniazid preventive therapy in Zimbabwe: has operational research influenced policy and practice?

Public Health Action 2018 Dec;8(4):218-224

International Union Against Tuberculosis and Lung Disease, Paris, France.

Following the operational research study conducted during the isoniazid preventive therapy (IPT) pilot phase in Zimbabwe, recommendations for improvement were adopted by the national antiretroviral therapy (ART) programme. To compare before (January 2013-June 2014) and after the recommendations (July 2014-December 2015), the extent of IPT scale-up and IPT completion rates, and after the recommendations the risk factors for IPT non-completion, in 530 ART clinics. Retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/pha.18.0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361487PMC
December 2018

A Two-Month-Old Child with Vascular Ectasia: A Case Report Diagnosed by Molecular Karyotyping.

J Pediatr Genet 2019 Mar 22;8(1):20-23. Epub 2018 Aug 22.

Department of Pathology, Çukurova Üniversity, Balcali Hospital, Adana, Turkey.

Gastrointestinal angiodysplasia can be encountered in cases with aortic stenosis, inflammatory gastrointestinal conditions, von Willebrand disease or vascular damage, and degenerative changes. Predisposing factors have been described in four adults with vascular ectasia located in the stomach, duodenum, and the distal esophagus. Here, we report a 2-month-old infant with vascular ectasia in the proximal esophagus and diagnosed by molecular karyotyping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1669385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375715PMC

Task shifting to improve the provision of integrated chronic care: realist evaluation of a lay health worker intervention in rural South Africa.

BMJ Glob Health 2019 29;4(1):e001084. Epub 2019 Jan 29.

Centre for Health Policy, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Task shifting is a potential solution to the shortage of healthcare personnel in low/middle-income countries, but contextual factors often dilute its effectiveness. We report on a task shifting intervention using lay health workers to support clinic staff in providing chronic disease care in rural South Africa, where the HIV epidemic and an ageing population have increased demand for care.

Methods: We conducted a realist evaluation in a cluster randomised controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgh-2018-001084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352781PMC
January 2019

Evaluation of the cardiovascular risk in patients with biliary stones: a descriptive cross-sectional study.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S14-S19

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: the aim of this study was evaluating the risk of cardiovascular disease in patients with gallstones.

Background: Gallstones is the most common Biliary System disorder which its prevalence is increasing. On other hand, cardiovascular disease is the most common cause of mortality in the world. Read More

View Article

Download full-text PDF

Source
January 2018

Abnormal renovascular resistance in dogs with diabetes mellitus: correlation with glycemic status and proteinuria.

Iran J Vet Res 2018 ;19(4):304-309

Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, Madras Veterinary College, TANUVAS, Chennai-600007, India.

Present study was conducted with the objectives of determining the renal vascular resistance in dogs with diabetes mellitus and to study the correlation between the indices of renovascular resistance with glycemic status, systolic blood pressure (SBP) and proteinuria in dogs with diabetes mellitus. This study was conducted on seventeen diabetic dogs and ten apparently healthy dogs. Increased renal resistive index (RI) and pulsatility index (PI) were observed in diabetic dogs as compared to healthy dogs. Read More

View Article

Download full-text PDF

Source
January 2018

Transforming cancer outcomes in England: earlier and faster diagnoses, pathways to success, and empowering alliances.

J Healthc Leadersh 2019 29;11:1-11. Epub 2019 Jan 29.

University of Manchester Division of Cancer Sciences, Greater Manchester Cancer, Manchester, UK.

Cancer outcomes and patient experience in England have never been better but survival remains worse than in comparable countries. Differences in stage at diagnosis and, to a lesser extent, access to optimal treatments are likely to be the most important factors. The national cancer plan emphasizes earlier and faster diagnosis and the creation of cancer alliances providing strategic leadership and coordination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JHL.S150924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357885PMC
January 2019

Subacromial impingement syndrome: management challenges.

Orthop Res Rev 2018 23;10:83-91. Epub 2018 Oct 23.

The Reading Shoulder Unit, Berkshire Independent Hospital Coley Park, Swallows Croft, Reading, Berkshire, UK,

The painful shoulder is the most common condition seen in specialist shoulder clinics. It is often associated with lack of range of motion and reduced shoulder function. Lack of sleep and difficulties in performing basic daily life activities are common findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/ORR.S157864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376459PMC
October 2018

Dexamethasone inhibits the proliferation of tumor cells.

Cancer Manag Res 2019 1;11:1141-1154. Epub 2019 Feb 1.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow, China.

Objective: Dexamethasone (DEX) is a glucocorticoid that is commonly used in clinics. Previously, DEX has been shown to inhibit the function of immune system; however, DEX is often used to treat side reactions, such as nausea and vomiting caused by chemotherapy in clinics. Therefore, it is necessary to study the role of DEX in the treatment of cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CMAR.S187659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362917PMC
February 2019

A novel approach to cardiovascular disturbances in patients with schizophrenia spectrum disorders treated with long-acting injectable medication.

Neuropsychiatr Dis Treat 2019 25;15:349-355. Epub 2019 Jan 25.

Medical Semiology II, Department of Internal Medicine I, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania.

Purpose: This research article assesses the cardiovascular impact of long-term injectable antipsychotic therapy on patients diagnosed with schizophrenia spectrum disorders. In our study, we attempted to quantify the potential causes of cardiovascular damage, assess cardiovascular parameters, and correlate them with the time elapsed from the onset of the psychosis until the initiation of injectable antipsychotic therapy, as well as the duration of long-acting therapy, and finally, to compare two of the most utilized long-acting injectable (LAI) medications (olanzapine vs risperidone).

Patients And Methods: This cross-sectional study recruited 64 patients of 2 outpatient clinics undergoing treatment with LAI antipsychotics for schizophrenic spectrum disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/NDT.S186892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354682PMC
January 2019

Piloting a structured developmental tool to assess transition readiness for youth with special health-care needs: A mixed-methods exploration of health-care provider experiences.

J Child Health Care 2019 Feb 17:1367493518823899. Epub 2019 Feb 17.

2 Fordham Graduate School of Social Service, New York, NY, USA.

This mixed-methods study examined providers' experiences using a structured developmentally sensitive tool to assess transition readiness for youth with special health-care needs moving from pediatric to adult care. Twenty-eight health-care providers from three pediatric specialty clinics reported their experiences using the tool by surveys and semistructured telephone interviews. Qualitative data were analyzed using thematic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1367493518823899DOI Listing
February 2019

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

Verrucous cyst: Possible precursor of proliferating epidermoid cyst.

J Cutan Pathol 2019 Feb 17. Epub 2019 Feb 17.

Department of Dermatology and Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (Stone).

A 68-year-old man presented for excision of a nodule on his right sub-mandibular neck that had grown quickly over a three-month period. Initially, it looked like an "ingrown hair," and he admitted to expressing blood-tinged fluid from the nodule multiple times. This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13443DOI Listing
February 2019

Early initiation of antiretroviral therapy for people newly diagnosed with HIV infection in Australia: trends and predictors, 2004-2015.

Med J Aust 2019 Feb 18. Epub 2019 Feb 18.

The Kirby Institute, University of New South Wales, Sydney, NSW.

Objectives: To determine trends in and predictors of early treatment for people newly diagnosed with human immunodeficiency virus (HIV) infection in Australia.

Design, Setting: Retrospective cohort analysis of routinely collected longitudinal data from 44 sexual health clinics participating in the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) program.

Participants: Patients diagnosed with HIV infections, January 2004 - June 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.50006DOI Listing
February 2019

The Quality of Systematic Reviews and Meta-Analyses in Erectile Dysfunction Treatment and Management Published in the Sexual Medicine Literature.

J Sex Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, Stanford Hospital and Clinics, Stanford, CA, USA.

Introduction: Erectile dysfunction (ED) is a common medical condition that requires high-quality evidence to guide clinical practice; however, systematic reviews (SRs) and meta-analyses (MAs) often vary in quality, raising concerns regarding the validity of their results.

Aim: To perform an objective analysis of SRs and MAs in ED treatment and management and to report on the quality of published literature.

Methods: A comprehensive search in PubMed/MEDLINE and EMBASE of 12 high-impact urology journals was used to identify relevant publications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.01.009DOI Listing
February 2019

Exploring Family-Medicine Providers' Perspectives on Group Care Visits for Maternal and Infant Nutrition Education.

J Nutr Educ Behav 2019 Feb 15. Epub 2019 Feb 15.

Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI. Electronic address:

Objective: Explore current maternal and infant nutrition education practices and family medicine primary care providers' views on a group care model to deliver nutrition education to mother-infant dyads.

Design: In-depth interviews.

Setting: Family medicine clinics in 1 Midwestern US hospital system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneb.2019.01.009DOI Listing
February 2019

Non-operative management of solid organ injuries in children: An American Pediatric Surgical Association Outcomes and Evidence Based Practice Committee systematic review.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric Surgery, University of Tennessee Health Science Center, Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN. Electronic address:

Purpose: The American Pediatric Surgical Association (APSA) guidelines for the treatment of isolated solid organ injury (SOI) in children were published in 2000 and have been widely adopted. The aim of this systematic review by the APSA Outcomes and Evidence Based Practice Committee was to evaluate the published evidence regarding treatment of solid organ injuries in children.

Methods: A comprehensive search strategy was crafted and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were utilized to identify, review, and report salient articles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2019.01.012DOI Listing
January 2019

Communicating Mammography Results: By What Method and How Quickly Do Women Want Their Screening Mammogram Results?

J Am Coll Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.

The purpose of the survey study was to understand the majority preference with regards to the wait time for screening mammogram results, whether prompt communication of mammogram results was of importance to patients, whether the time frame to schedule an additional imaging follow-up appointment after an abnormal screening mammogram was important to patients, and how patients preferred to be given their screening mammogram results. There were 2,245 patients who participated in the survey. A majority of patients preferred to receive screening mammogram results on Friday (n = 1,868, 85. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacr.2018.12.006DOI Listing
February 2019

Recruitment of hard to contact, hard to engage child populations in clinics and schools.

Appl Nurs Res 2018 Dec 18. Epub 2018 Dec 18.

Belmont University, Nashville, TN, United States of America.

Recruiting children with chronic disease or subgroups of children (low income, obese, specific ages, types of cancer) from clinics and schools for research studies may be particularly difficult. While some have deemed such groups as hard to reach, these groups may be more accurately described as either hard to contact or hard to engage. This is not because children are unknown to the school or clinic but because the researcher's ability to communicate directly with targeted children prior to enrollment is limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.apnr.2018.12.004DOI Listing
December 2018