53,494 results match your criteria Clinician News[Journal]


Inferring sleep stage from local field potentials recorded in the subthalamic nucleus of Parkinson's patients.

J Sleep Res 2018 Dec 13:e12806. Epub 2018 Dec 13.

Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.

Parkinson's disease (PD) is highly comorbid with sleep dysfunction. In contrast to motor symptoms, few therapeutic interventions exist to address sleep symptoms in PD. Subthalamic nucleus (STN) deep brain stimulation (DBS) treats advanced PD motor symptoms and may improve sleep architecture. Read More

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December 2018

Supporting positive parenting practices within a community-based music therapy group program: Pilot study findings.

J Community Psychol 2018 Dec 12. Epub 2018 Dec 12.

The University of Melbourne, Australia.

The aim of this study was to evaluate the benefits of a short-term, community-based music therapy group program on positive parenting practices. Parent-child dyads receiving early intervention family services (N = 199) participated in 8 weekly, 45-60 minute, music-based group play sessions. We analyzed pre-post parent self-reports that measured parenting competency and clinician-observed ratings of parental responsiveness that evaluated behavioral domains of play, praise, and consistency. Read More

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December 2018

A qualitative evaluation of the effects of Metacognitive Reflection and Insight Therapy: 'Living more consciously'.

Psychol Psychother 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Psychology and Experimental Psychopathology, Faculty of Behavioral Sciences, University of Groningen, The Netherlands.

Objectives: Extensive research showed that one of the major difficulties that people with schizophrenia spectrum disorders are struggling with involves their ability to reflect on their own and others' mental activities, also defined as metacognition. Several new psychotherapies have been developed to assist patients (re)gain metacognitive capacity, including Metacognitive Reflection and Insight Therapy (MERIT). The current study investigated the client's subjective experience of psychotherapy, to determine whether service users found MERIT effective and whether these gains align with quantitative findings, which processes they considered responsible for these benefits, in which ways participants found MERIT similar or different from other interventions, and whether they experienced non-desirable factors and outcomes. Read More

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December 2018

Review article: A primer for clinical researchers in the emergency department: Part VII. Considering a research higher degree in emergency medicine: How does it work, where to start, what to consider.

Emerg Med Australas 2018 Dec 11. Epub 2018 Dec 11.

Paediatric Research in Emergency Departments International Collaborative (PREDICT), Melbourne, Victoria, Australia.

In this series we address important topics for clinicians who participate in research or are considering research as part of their career path in emergency medicine. While much emergency research is successfully done by clinicians without a research higher degree (RHD), undertaking a master's degree or doctorate allows a research topic to be pursued in greater depth. It also provides a solid basis for a future research career in terms of research quality, advanced skills, academic progression and track record, as well as eligibility for grants and RHD supervision. Read More

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December 2018

Cancer Survivors' Experiences with Breakdowns in Patient-Centered Communication.

Psychooncology 2018 Dec 10. Epub 2018 Dec 10.

Meyers Primary Care Institute, a partnership with University of Massachusetts Medical School, Reliant Medical Group and Fallon Health, Worcester, MA.

Objective: This study analyzed cancer survivors' communication experiences that fell short of being patient-centered. Patients' descriptions of communication 'breakdowns' were analyzed according to domain (e.g. Read More

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December 2018

Interprofessional Perspectives on Providing Spiritual Care for Patients With Lung Cancer in Outpatient Settings.

Oncol Nurs Forum 2019 Jan;46(1):49-58

City of Hope Comprehensive Cancer Center.

Purpose: To explore palliative care and oncology clinicians' perspectives on current challenges and facilitating factors in meeting the spiritual needs of patients with lung cancer and family caregivers. This study was conducted in preparation for a community-based lung cancer palliative care intervention.

Participants & Setting: 19 oncology and palliative care clinicians in three outpatient Kaiser Permanente sites in southern California. Read More

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January 2019

Qualitative study exploring the phenomenon of multiple electronic prescribing systems within single hospital organisations.

BMC Health Serv Res 2018 Dec 14;18(1):969. Epub 2018 Dec 14.

Research Department of Practice and Policy, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.

Background: A previous census of electronic prescribing (EP) systems in England showed that more than half of hospitals with EP reported more than one EP system within the same hospital. Our objectives were to describe the rationale for having multiple EP systems within a single hospital, and to explore perceptions of stakeholders about the advantages and disadvantages of multiple systems including any impact on patient safety.

Methods: Hospitals were selected from previous census respondents. Read More

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December 2018

Recurrent paroxysmal atrial fibrillation induced by marked hypoxia during sleep-disordered breathing.

J Cardiol Cases 2016 Sep 3;14(3):87-89. Epub 2016 Jun 3.

Department of Cardiovascular Medicine, Saiseikai Futsukaichi Hospital, Fukuoka, Japan.

Sleep-disordered breathing (SDB) has a big impact on autonomic nervous activity and thus induces or deteriorates various cardiovascular diseases. We here describe a typical but rarely documented case which clearly indicates a strong link between SDB and cardiovascular disease. A 68-year-old woman complaining of frequent palpitations was referred to our institute. Read More

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September 2016

Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice.

J Cardiol Cases 2015 Oct 3;12(4):126-129. Epub 2015 Jul 3.

Advocate Christ Medical Center, Covington Ct, Oak Brook, IL, USA.

There have been few cases in recent times where QT interval prolongation has been studied with regards to the use of diphenhydramine. We present a case of a patient who presented because of shortness of breath and needed emergent hemodialysis; during the course of which he developed prolonged QT interval on electrocardiography, which was correlated interestingly with the use of diphenhydramine. Pruritus is a common symptom experienced by dialysis patients. Read More

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October 2015

Group Therapy for Substance Use Disorders: A Survey of Clinician Practices.

J Groups Addict Recover 2017 8;12(4):243-259. Epub 2017 Dec 8.

Department of Psychology, University of Michigan.

Substance use disorder (SUD) treatment is typically delivered in group format, but clinical research focuses on individual therapy. This exploratory study narrows this gap through a survey of 566 SUD group clinicians in the United States, concerning most commonly used group practices, attitudes about evidence-based treatments (EBTs), and beliefs about addiction. Clinicians reported high use of open groups, moderately high utilization of EBT practices, and moderate use of questionable practices. Read More

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December 2017

The Language of Caring: Quantitating Medical Practice Patterns using Symbolic Dynamics.

Math Model Nat Phenom 2010 28;5(3):165-172. Epub 2010 Apr 28.

Departments of Critical Care Medicine and Medicine, University of Pittsburgh and Pittsburgh Veterans Affairs Healthcare System.

Real-world medical decisions rarely involve binary sole condition present or absent-patterns of patient pathophysiology. Similarly, provider interventions are rarely unitary in nature: the clinician often undertakes multiple interventions simultaneously. Conventional approaches towards complex physiologic derangements and their associated management focus on the frequencies of joint appearances, treating the individual derangements of physiology or elements of intervention as conceptually isolated. Read More

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Intuitive Clinician Control Interface for a Powered Knee-Ankle Prosthesis: A Case Study.

IEEE J Transl Eng Health Med 2018 23;6:2600209. Epub 2018 Nov 23.

Department of BioengineeringThe University of Texas at DallasRichardsonTX75080USA.

This paper presents a potential solution to the challenge of configuring powered knee-ankle prostheses in a clinical setting. Typically, powered prostheses use impedance-based control schemes that contain several independent controllers which correspond to consecutive periods along the gait cycle. This control strategy has numerous control parameters and switching rules that are generally tuned by researchers or technicians and not by a certified prosthetist. Read More

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November 2018

Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis.

Nat Rev Neurol 2018 Dec 13. Epub 2018 Dec 13.

Division of Anaesthesia, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Cerebral autoregulatory dysfunction after traumatic brain injury (TBI) is strongly linked to poor global outcome in patients at 6 months after injury. However, our understanding of the drivers of this dysfunction is limited. Genetic variation among individuals within a population gives rise to single-nucleotide polymorphisms (SNPs) that have the potential to influence a given patient's cerebrovascular response to an injury. Read More

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December 2018
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Impact of Patient- and Clinician-Reported Cumulative Toxicity on Quality of Life in Patients With Metastatic Castration-Naïve Prostate Cancer.

J Natl Compr Canc Netw 2018 Dec;16(12):1481-1488

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Cancer Center Amsterdam, and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands; Inserm, UMR 912 'Economic and Social Sciences, Health Systems and Societies (SESSTIM)', Aix-Marseille Université, IRD, Marseille, France; Department of Medical Psychology, Academic Medical Center Amsterdam, Cancer Center Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics Amsterdam Public Health Research Institute, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; Medical Oncology, Centre François Baclesse - CHU Côte de Nacre, Caen, France; Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif, France; UNICANCER, Paris, France; Department of Biostatistic, Institut Paoli-Calmettes, Marseille, France; Aix Marseille Université, INSERM, IRD, SESSTIM, Marseille, France; Centre Hospitalier Universitaire Rangueil, Toulouse, France; Hôpital Européen Georges Pompidou, Paris, France; and Institut Paoli-Calmettes, Aix-Marseille University, Centre de Recherche en Cancerologie de Marseille (CRCM), Marseille, France.

Current toxicity evaluation is primarily focused on high-grade adverse events (AEs) reported by clinicians. However, the cumulative effect of multiple lower-grade AEs may also impact patients' quality of life (QoL). Further, patient-reported toxicity may be more representative of patients' treatment experiences. Read More

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December 2018

Extracting tumour prognostic factors from a diverse electronic record dataset in genito-urinary oncology.

Int J Med Inform 2019 Jan 23;121:53-57. Epub 2018 Oct 23.

Austin Health, Department of Radiation Oncology, Melbourne, Australia; Department of Cancer Medicine, Latrobe University, Melbourne, Australia.

Objectives: To implement a system for unsupervised extraction of tumor stage and prognostic data in patients with genitourinary cancers using clinicopathological and radiology text.

Methods: A corpus of 1054 electronic notes (clinician notes, radiology reports and pathology reports) was annotated for tumor stage, prostate specific antigen (PSA) and Gleason grade. Annotations from five clinicians were reconciled to form a gold standard dataset. Read More

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January 2019

Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in a randomized trial.

BMC Psychiatry 2018 Dec 13;18(1):388. Epub 2018 Dec 13.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Würzburg, Würzburg, Germany.

Background: The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Read More

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December 2018
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Facial Esthetic Considerations with All-on-4: A Report on Two Cases.

Int J Periodontics Restorative Dent 2019 Jan/Feb;39(1):57-64

This article describes two case reports of immediate full-arch dental implant- supported prostheses using facial parameters to determine the anticipated incisal edge (AIE) position. Treatment planning the terminal dentition is driven by several facial parameters. A frontal photo is obtained to assess the facial thirds and the symmetry in the lower third. Read More

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December 2018

Adherence with a low-FODMAP diet in irritable bowel syndrome: are eating disorders the missing link?

Eur J Gastroenterol Hepatol 2018 Dec 12. Epub 2018 Dec 12.

GI Physiology Unit.

Objectives: The low-FODMAP diet has emerged as an option for the treatment of irritable bowel syndrome (IBS). This diet is very restrictive, and compliance is usually low. Preliminary findings suggest an association between eating disorders (EDs) and the risk of developing IBS. Read More

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December 2018

Relevance of total PSA and free PSA prescriptions.

Ann Biol Clin (Paris) 2018 Dec;76(6):659-663

Service de biochimie clinique et génétique, CHU Créteil, AP-HP, France.

The total PSA testing has been frequently criticized for its effectiveness in the early detection of prostate cancer. These widely resumed in and out of the medical community have led to a decrease in prescriptions. Recommendations against the use of PSA for screening have been issued in France and in most countries. Read More

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December 2018

The evidence-based approach for surgical complications in the treatment of lumbar disc herniation.

Int Orthop 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopedic Surgery, University of California Davis, 4860 Y Street Suite 3700, Sacramento, CA, 95817, USA.

Purpose: The purpose of this article is to review the evidence-based approach for surgical complications following disc herniation.

Methods: A search of the primary English literature was conducted for research examining the outcomes and complications of surgical discectomy. Special regard was given to high-quality prospective randomized studies. Read More

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December 2018

Timeliness of Postmarket Studies for New Pharmaceuticals Approved Between 2009 and 2012: a Cross-Sectional Analysis.

J Gen Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

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December 2018

Associative stigma experienced by mental health professionals in China and the United States.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 12. Epub 2018 Dec 12.

The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.

Purpose: "Associative stigma" is the negative stereotyping of mental health service providers who treat people with serious mental illness. The Clinician Associative Stigma Scale (CASS) has been validated in a US sample but not in other nations, e.g. Read More

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December 2018

The role of the psychologist in the veterans administration's patient aligned care team and huddle: A review, practical recommendations, and a call to action.

Health Psychol Res 2018 May 7;6(1):7393. Epub 2018 Nov 7.

C.W. Bill Young VAMC, Bay Pines VA Healthcare System, Bay Pines, FL, USA.

The Veterans Administration (VA)'s Patient Aligned Care Team (PACT) model has been a cornerstone of primary care in the VA healthcare system and has indicated the need for an organizational cultural shift towards interdisciplinary care. Most of the focus in PACT has been on the traditional providers of the medical model, with little attention focused on the role of the psychologist. This paper examines how psychologists can assist in the PACT model and, in particular, within the team VA huddle. Read More

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Randomized controlled trial evaluating the utility of urine HPV DNA for cervical cancer screening in a Pacific Island population.

J Glob Health Rep 2018 6;2. Epub 2018 Jul 6.

John A. Burns School of Medicine, Honolulu, Hawaii, USA.

Background: Non-invasive, self-collection sampling methods for human papillomavirus (HPV) DNA detection have the potential to address logistical and cultural barriers to Pap screening, particularly in under resourced settings such as Yap state in the Federated States of Micronesia - a population with low levels of screening and high incidence of cervical cancer.

Methods: A randomized controlled trial was conducted among adult women in Yap to compare cervical HPV DNA in self-collected urine and clinician-collected liquid cytology. Adult women aged 21-65 (n=217) were randomized by the order of sample collection. Read More

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Design and protocol for a pragmatic randomised study to optimise screening, prevention and care for tuberculosis and HIV in Malawi (PROSPECT Study).

Wellcome Open Res 2018 18;3:61. Epub 2018 May 18.

London School of Hygiene & Tropical Medicine, London, UK.

Adults seeking diagnosis and treatment for tuberculosis (TB) and HIV in low-resource settings face considerable barriers and have high pre-treatment mortality. Efforts to improve access to prompt TB treatment have been hampered by limitations in TB diagnostics, with considerable uncertainty about how available and new tests can best be implemented. The PROSPECT Study is an open, three-arm pragmatic randomised study that will investigate the effectiveness and cost-effectiveness of optimised HIV and TB diagnosis and linkage to care interventions in reducing time to TB diagnosis and prevalence of undiagnosed TB and HIV in primary care in Blantyre, Malawi. Read More

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Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.

Front Pediatr 2018 13;6:346. Epub 2018 Nov 13.

Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.

Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared. This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRP plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates. Read More

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November 2018

Barriers to Education and Shared Decision Making in the Chronic Kidney Disease Population: A Narrative Review.

Can J Kidney Health Dis 2018 2;5:2054358118803322. Epub 2018 Nov 2.

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Purpose Of Review: Provision of education to inform decision making for renal replacement therapy (RRT) is a key component in the management of chronic kidney disease (CKD), yet patients report suboptimal satisfaction with the process of selecting a dialysis modality. Our purpose is to review the influencers of RRT decision making in the CKD population, which will better inform the process of shared decision making between clinicians and patients.

Sources Of Information: PubMed and Google Scholar. Read More

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November 2018

Drug samples in family medicine teaching units: a cross-sectional descriptive study: Part 2: portrait of drug sample management in Quebec.

Can Fam Physician 2018 Dec;64(12):e540-e545

Family physician in the Herzl Family Practice Centre in Montreal and Associate Professor in the Department of Family Medicine at McGill University.

Objective: To draw a portrait of drug sample management in academic primary health care settings and assess conformity to existing Canadian guidelines.

Design: Descriptive cross-sectional survey.

Setting: All 33 family medicine teaching units (FMTUs) in Quebec that kept drug samples. Read More

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December 2018

Preference of specimen collection methods for human papillomavirus detection for cervical cancer screening: a cross-sectional study of high-risk women in Mombasa, Kenya.

Reprod Health 2018 Dec 12;15(1):206. Epub 2018 Dec 12.

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objectives: Self-collection of genital specimens for high-risk types of human papillomavirus (hrHPV) detection may increase cervical cancer screening uptake. We hypothesized that women would prefer self-collection to clinician-collection of genital specimens. To test this hypothesis, and women's preference between two different self-collection approaches, a total of 199 women were enrolled in a cross-sectional study in Mombasa, Kenya. Read More

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December 2018

Polio eradication in Nigeria: evaluation of the quality of acute flaccid paralysis surveillance documentation in Bauchi state, 2016.

BMC Public Health 2018 Dec 13;18(Suppl 4):1307. Epub 2018 Dec 13.

Global Public Health Solutions, Atlanta, GA, USA.

Background: Nigeria is the only country in Africa that is yet to be certified as polio free. Surveillance for acute flaccid paralysis (AFP) is the foundation of the polio eradication initiative since it provides information to alert both health managers and clinician that timely actions should be initiated to interrupt transmission of the polio virus. The strategy also provides evidence for the absence of wild poliovirus. Read More

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December 2018

Improving treatment for patients with childhood abuse related posttraumatic stress disorder (IMPACT study): protocol for a multicenter randomized trial comparing prolonged exposure with intensified prolonged exposure and phase-based treatment.

BMC Psychiatry 2018 Dec 12;18(1):385. Epub 2018 Dec 12.

Leiden University, Institute of Psychology, Wassenaarsweg 22, 3332, AK, Leiden, The Netherlands.

Background: Childhood abuse related posttraumatic stress disorder (CA-PTSD) is associated with a high burden of disease and with treatment response rates that leave room for improvement. One of the treatments for PTSD, prolonged exposure (PE), is effective but has high drop-out rates and remission rates are relatively low. An intensified form of PE (iPE) was associated with good response and low drop-out rates in PTSD and has not yet been tested in a controlled trial in CA-PTSD. Read More

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December 2018

Mycobacterium mucogenicum bacteremia: major role of clinical microbiologists.

BMC Infect Dis 2018 Dec 12;18(1):646. Epub 2018 Dec 12.

Service Universitaire des Maladies Infectieuses et du voyageur, Centre Hospitalier Dron, 135 avenue du Président Coty, 59200, Tourcoing, France.

Introduction: Mycobacterium mucogenicum is a rare but emerging cause of infections, especially in immunocompromised patients.

Case Presentation: We describe a new case of M. mucogenicum catheter-related bloodstream infection in a 34-year-old woman with ovarian cancer. Read More

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December 2018

Tumor-to-Tumor Metastasis - a Unique Case of Clear Cell Renal Cell Carcinoma Harboring Metastasis of Adenocarcinoma of Unknown Origin.

Klin Onkol 2018 ;31(5):366-370

Background: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin.

Case: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. Read More

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January 2018

Medication nonadherence in bipolar disorder: a narrative review.

Ther Adv Psychopharmacol 2018 Dec 16;8(12):349-363. Epub 2018 Oct 16.

Academic Psychiatry, Wolfson Research Centre, Campus for Ageing and Vitality, Northern Centre for Mood Disorders and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

A number of effective maintenance medication options exist for bipolar disorder (BD) and these are regarded as the foundation of long-term treatment in BD. However, nonadherence to medication is common in BD. For example, a large data base study in the United States of America (USA) showed that approximately half of patients with BD were nonadherent with lithium and maintenance medications over a 12 month period. Read More

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December 2018

The clinician-patient working alliance: Is it a significant predictor of psychiatric medication adherence in a sample of recently released parolees?

Authors:
Stacy Calhoun

J Forens Psychiatry Psychol 2018 23;29(5):782-793. Epub 2018 May 23.

UCLA Integrated Substance Abuse Programs, 11075 Santa Monica Blvd., Suite 200, Los Angeles, CA 90025.

Persistent psychiatric symptoms can serve as a major barrier to the successful reintegration of parolees with mental illness. Thus, it is important to identify factors that might impact their mental health recovery, such as low adherence to their treatment regimen. Although many studies have examined the issue of psychiatric medication nonadherence, very few studies have focused specifically on justice-involved individuals. Read More

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Rare Occurrence of Incidental Finding of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Hürthle Cell Adenoma.

Med Arch 2018 Nov;72(5):367-370

Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, Croatia.

Introduction: Hürthle cell adenoma is a rare benign lesion of the thyroid gland, however, controversies about its potential malignant behavior still remain. Among thyroid neoplasms, papillary carcinoma is the most common variant with great variety of histological subtypes demonstrating different biological behavior.

Aim: To raise the awareness of possible coexistence of these two lesions and discussion about possible therapeutic approaches. Read More

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November 2018

Targeted next-generation sequencing approach for molecular genetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous polyposis coli gene causes familial adenomatous polyposis.

Mol Genet Genomic Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.

Background: Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease which primarily manifested with developing adenomas or polyps in colon or rectum. It is caused by the germline mutations in adenomatous polyposis coli (APC) gene. Patients with FAP are usually manifested with "hundreds or even thousands" adenomas or polyps in colon or rectum. Read More

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December 2018

Red blood cell transfusion in southern Finland from 2011 to 2016: a quality audit.

Transfus Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: The current trends in RBC use and pre- and post-transfusion Hb levels were analysed to improve practice and to provide international comparison.

Background: Indications for RBC transfusion have changed with growing scientific evidence. The lowest acceptable haemoglobin (Hb) level has decreased, and transfusing single units instead of pairs has become the new standard. Read More

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December 2018

Structural white matter networks in myotonic dystrophy type 1.

Neuroimage Clin 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Reinier Postlaan 4, 6525 GC, Nijmegen; Department of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands. Electronic address:

The myriad of neuropsychiatric manifestations reported in myotonic dystrophy type 1 may have its origin in alterations of complex brain network interactions at the structural level. In this study, we tested the hypothesis that altered white matter microstructural integrity and network organisation were present in a cohort of individuals with DM1 compared to unaffected controls, which was expected to be associated with CNS related disease manifestations of DM1. We performed a cross-sectional neuropsychological assessment and brain MRI in 25 myotonic dystrophy type 1 (DM1) patients and 26 age, sex and educational level matched unaffected controls. Read More

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November 2018
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The future of recovery - Integrated, digitalised and in real time.

Best Pract Res Clin Anaesthesiol 2018 Sep - Dec;32(3-4):295-302. Epub 2018 Apr 10.

Department of Surgery, University of Melbourne, Level 6, Centre for Medical Research, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia. Electronic address:

Traditional perioperative risk prediction recovery identifies patient populations at risk of suboptimal recovery but not individual patients in whom this actually occurs and in whom timely intervention is beneficial. Patient-focused recovery emphasises a return to a semblance of normality and an ability to perform activities previously undertaken. A patient's sense of self-efficacy and engagement in their own care positively influences functional improvement and emotive recovery. Read More

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Generalizing remotely supervised transcranial direct current stimulation (tDCS): feasibility and benefit in Parkinson's disease.

J Neuroeng Rehabil 2018 Dec 7;15(1):114. Epub 2018 Dec 7.

New York University Langone Health, New York, USA.

Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been shown to improve common symptoms of neurological disorders like depressed mood, fatigue, motor deficits and cognitive dysfunction. tDCS requires daily treatment sessions in order to be effective. We developed a remotely supervised tDCS (RS-tDCS) protocol for participants with multiple sclerosis (MS) to increase accessibility of tDCS, reducing clinician, patient, and caregiver burden. Read More

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December 2018

Red ear syndrome: Perspectives for the otolaryngologist.

Ear Nose Throat J 2018 Dec;97(12):E11-E14

Department of Otolaryngology, Lenox Hill Hospital/Northwell Health, 110-11 72nd Ave., Suite 1B, Forest Hills, NY 11375, USA.

Red ear syndrome (RES) is an unusual, often unrecognized condition that has rarely been reported in the otolaryngology literature despite the presence of symptoms and associated disorders of relevance to the otolaryngologist. When present, RES may have diagnostic value when uncertainties arise in cases of sinus headache and referred otalgia. Despite the appearance of a distinctive red ear, as well as symptoms and associated disorders relating to otolaryngology, discussion of RES is generally limited to neurology-based publications. Read More

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December 2018
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Antiemetic Drug Use in Children: What the Clinician Needs to Know.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy.

Vomiting is not only unpleasant for both children and families, but can lead to frequent hospital admission. The persistent vomiting hampers oral intake and increases the risk of dehydration so the proper use of antiemetic drugs can be useful. The pharmacological treatment of vomiting in children remains a challenge for the pediatrician because several antiemetics are prescribed as "off-label", outside their authorized drug label. Read More

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December 2018

The Titration and Tolerability of Sacubitril/Valsartan for Patients with Heart Failure in Clinical Practice.

J Cardiovasc Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

University of Alberta, Edmonton, Canada.

Little is known about the dosing and tolerability of sacubitril/valsartan (LCZ696; Entresto™, Quebec, Canada) in a non-clinical trial population. This study was conducted to evaluate the use and tolerability of sacubitril/valsartan in patients followed at a multidisciplinary heart failure clinic. We performed a retrospective chart review of 126 patients with heart failure, initiated on sacubitril/valsartan, and seen at a specialty heart failure clinic between August 1, 2015 and August 1, 2017. Read More

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December 2018

Development and Usability Testing of the Society for Pediatric Anesthesia Pedi Crisis Mobile Application.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

United States National Aeronautics and Space Administration, Ames Research Center, Moffett Field, California.

When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. Read More

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December 2018
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Physiotherapy practice patterns in gait rehabilitation for adults with acquired brain injury.

Brain Inj 2018 Dec 12:1-16. Epub 2018 Dec 12.

a Department of Physical Therapy , University of Toronto , Toronto , Canada.

Objective: Gait dysfunction is common following acquired brain injury (ABI). Clinical practice guidelines can improve patient outcomes; however, information regarding ABI-specific management of gait dysfunction is limited. This study aimed to describe practice patterns of Canadian physiotherapists regarding gait rehabilitation in adults post-ABI. Read More

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December 2018

Association of Screening and Treatment for Preoperative Asymptomatic Bacteriuria With Postoperative Outcomes Among US Veterans.

JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: Limited data suggest that screening for asymptomatic bacteriuria (ASB) prior to nonurologic procedures is not useful. However, high-quality evidence to support consensus recommendations and influence clinical practice is lacking.

Objective: To characterize the association between detection and treatment of preoperative ASB and postoperative outcomes. Read More

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December 2018
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Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

J Cancer Res Ther 2018 Dec;14(Supplement):S1237-S1240

Department of Conservative and Endodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.

Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and unwarranted therapy by an inexperienced clinician who may mistake it for a more serious pathologic condition. Read More

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December 2018
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Symptoms as Patient-Reported Outcomes in Cancer Patients Undergoing Immunotherapies.

Authors:
Tito R Mendoza

Adv Exp Med Biol 2018 ;995:165-182

Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cancer therapies are toxic. Newer oncological treatments such as immunotherapy produce unconventional adverse events that are collectively referred to as immune-related adverse events (irAEs). These irAEs are clinician-rated and typically reported via tabulation of adverse events from the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE). Read More

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January 2018