3,103 results match your criteria Clinical oral investigations[Journal]


Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population.

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Periodontal Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Objectives: Periodontal inflammation is regarded as a risk factor for drug-induced gingival overgrowth (DIGO). In order to elucidate the involvement of periodontal inflammation in DIGO, the periodontal status of subjects who do not develop DIGO despite receiving causative drugs (non-responders) needs to be examined. Therefore, the aim of the present study which was a pilot study was to assess periodontal inflammatory variables in responders (calcium channel blocker induced-GO patients), non-responders, and patients who did not receive causative drugs (non-consumers). Read More

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http://dx.doi.org/10.1007/s00784-019-02846-8DOI Listing
February 2019
1 Read

Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy?

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Graduate Program of Biomedical Sciences, Herminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil.

Objectives: Evaluate the bone remodeling during orthodontic movement with corticotomy when submitted to low-intensity electrical stimulation application (microcurrent-MC) and low-level laser therapy (LLLT).

Material And Methods: One hundred and fifty Wistar rats were divided into the following 5 groups: (C) submitted to tooth movement; (Cort) tooth movement/corticotomy; (Cort-L) tooth movement/corticotomy/laser AsGaAl 808 nm (4.96J/50s); (Cort-Mc) tooth movement/corticotomy/microcurrent (10 μA/5 min); (Cort-L-Mc) tooth movement/corticotomy and laser/microcurrent alternated. Read More

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http://dx.doi.org/10.1007/s00784-019-02845-9DOI Listing
February 2019

Different light-activation systems associated with dental bleaching: a systematic review and a network meta-analysis.

Clin Oral Investig 2019 Feb 14. Epub 2019 Feb 14.

Department of Restorative Dentistry, State University of Ponta Grossa, Rua Carlos Cavalcanti, 4748, Bloco M, Sala 64-A, Uvaranas, Ponta Grossa, Paraná, 84030-900, Brazil.

Objectives: A systematic review and a network meta-analysis were performed to answer the following research question: "Is there any light-activation protocol capable of improving color change efficacy when associated with an in-office bleaching gel in adults?"

Material And Methods: A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, and SIGLE without date and/or language restrictions in April 23, 2017 (updated on March 30, 2018). IADR abstracts (1990-2018), unpublished and ongoing trial registries, dissertations, and theses were also searched. Only randomized clinical trials conducted in adults that included at least one group treated with in-office dental bleaching with light activation were included. Read More

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http://dx.doi.org/10.1007/s00784-019-02835-xDOI Listing
February 2019

Effectiveness of the ozone application in two-visit indirect pulp therapy of permanent molars with deep carious lesion: a randomized clinical trial.

Clin Oral Investig 2019 Feb 13. Epub 2019 Feb 13.

Department of Pedodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.

Objectives: The aim of this randomized, three-arm parallel, single-blinded clinical trial was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy.

Materials And Methods: One hundred five lower first molar teeth with deep caries lesion were included and randomly assigned three groups to apply the two-visit indirect pulp therapy. Treatment procedure was applied without any disinfectant (control), with 60-s 2% chlorhexidine digluconate (CHX) or 60-s ozone application. Read More

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http://dx.doi.org/10.1007/s00784-019-02808-0DOI Listing
February 2019
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Different surface modifications combined with universal adhesives: the impact on the bonding properties of zirconia to composite resin cement.

Clin Oral Investig 2019 Feb 12. Epub 2019 Feb 12.

Scientific Head of Dental Material Unit, Department of Prosthetic Dentistry, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

Objective: The purpose of this study was to analyze the impact of plasma treatment and (universal adhesives) UAs on the bonding properties of zirconia.

Material And Methods: Zirconia specimens (N = 744; n = 186/pretreatment) were prepared, highly polished, and pretreated: (i) plasma (oxygen plasma, 10s, 5 mm), (ii) airborne-particle abrasion (alumina, 50 μm, 0.05 MPa, 5 s, 10 mm), (iii) airborne-particle abrasion + plasma, and (iv) without pretreatment (highly polished surface). Read More

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http://dx.doi.org/10.1007/s00784-019-02825-zDOI Listing
February 2019
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Both non-surgical dental treatment and extractions increase the risk of medication-related osteonecrosis of the jaw: case-control study.

Clin Oral Investig 2019 Feb 12. Epub 2019 Feb 12.

School of Dentistry and Oral Health, Griffith University, Southport, Queensland, 4222, Australia.

Objectives: Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition whose risk factors remain unclear. The aim of this study is to investigate the role of oral health and of dental treatment in the development of MRONJ.

Materials And Methods: A case-control study was conducted in Brisbane, Australia. Read More

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http://dx.doi.org/10.1007/s00784-019-02828-wDOI Listing
February 2019

Polymerization pattern characterization within a resin-based composite cured using different curing units at two distances.

Clin Oral Investig 2019 Feb 9. Epub 2019 Feb 9.

Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.

Objectives: To investigate the relationship of the irradiance-beam-profile areas from six different light-curing units (LCUs) with the degree of conversion (DC), microhardness (KH), and cross-link density (CLD) throughout a resin-based composite (RBC) cured at two clinically relevant distances, and to explore the correlations among them.

Materials And Methods: A mapping approach was used to measure DC using micro-Raman spectroscopy, KH using a Knoop indentor on a hardness tester, and %KH reduction after ethanol exposure, as an indicator for CLD within a nano-hybrid RBC increment (n = 3) at various depths. These sample composites were cured from two distances while maintaining the radiant exposure, using six different light-curing units: one quartz-tungsten-halogen; two single and three multiple-emission-peak light-emitting-diode units. Read More

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http://link.springer.com/10.1007/s00784-019-02831-1
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http://dx.doi.org/10.1007/s00784-019-02831-1DOI Listing
February 2019
1 Read

Visibility, location, and morphology of the primary maxillary sinus ostium and presence of accessory ostia: a retrospective analysis using cone beam computed tomography (CBCT).

Clin Oral Investig 2019 Feb 9. Epub 2019 Feb 9.

Oral and Maxillofacial Radiology, Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Objectives: This retrospective study evaluated the visibility, location, and morphology of the primary maxillary ostium (PMO), as well as the presence and number of accessory maxillary ostia (AMO) in the maxillary sinus using cone beam computed tomography (CBCT).

Materials And Methods: CBCT scans with a large field of view with both maxillary sinuses entirely visible, acquired from February 2016 to February 2018, were initially screened. Patients were included if there was no history of surgical intervention/trauma in the sinus region. Read More

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http://link.springer.com/10.1007/s00784-019-02829-9
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http://dx.doi.org/10.1007/s00784-019-02829-9DOI Listing
February 2019
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Microbiological dynamics of red complex bacteria following full-mouth air polishing in periodontally healthy subjects-a randomized clinical pilot study.

Clin Oral Investig 2019 Feb 6. Epub 2019 Feb 6.

Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center of Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.

Objectives: Suppression of periodontal pathogens in the oral cavity of periodontally healthy individuals may lower the risk for periodontal or periimplant diseases. Therefore, the present study aimed to analyze the effect of supragingival debridement (SD) with adjunctive full mouth glycine powder air polishing (FM-GPAP) on the prevalence of periodontal pathogens in periodontally healthy individuals.

Materials And Methods: Eighty-seven systemically and periodontally healthy intraoral carriers of red complex bacteria, i. Read More

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http://dx.doi.org/10.1007/s00784-019-02821-3DOI Listing
February 2019

Correlation of magnetic resonance imaging grades with cytokine levels of synovial fluid of patients with temporomandibular joint disorders: a cross-sectional study.

Clin Oral Investig 2019 Feb 6. Epub 2019 Feb 6.

Department of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong Street, Section 2, Taipei, 11221, Taiwan.

Objectives: Magnetic resonance imaging (MRI) is a standardized method for assisting joint diagnosis. To validate the reliability of different imaging-based grading systems, this study examined (1) the associations between grading systems for osseous change, joint effusion, and the Wilkes classification of temporomandibular joint (TMJ) disorders and (2) the correlation between cytokines in synovial fluid and imaging-based joint scores.

Materials And Methods: Twenty-seven patients, who routinely received numeric rating scale (NRS) and MRI assessment before TMJ arthrocentesis, were enrolled. Read More

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http://dx.doi.org/10.1007/s00784-019-02817-zDOI Listing
February 2019

Can lithium disilicate ceramic crowns be fabricated on the basis of CBCT data?

Clin Oral Investig 2019 Feb 6. Epub 2019 Feb 6.

Department of Prosthodontics, University Hospital, LMU, Munich, Germany.

Objectives: Evaluating the fit of CAD/CAM lithium disilicate ceramic crowns fabricated on basis of direct and indirect digitalization of impressions by CBCT or of dental casts.

Material And Methods: A metal model with a molar chamfer preparation was digitized (n = 12 per group) in four ways: IOS-direct digitalization using an Intra-Oral scanner (CS3600), cone-beam computed tomography scan (CBCT 1)-indirect digitalization of impression (CBCT-CS9300), CBCT 2-indirect digitalization of impression (CBCT-CS8100), and Extra-Oral scanner (EOS)-indirect digitalization of gypsum-cast (CeramillMap400). Accuracy of 3D datasets was evaluated in relation to a reference dataset by best-fit superimposition. Read More

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http://dx.doi.org/10.1007/s00784-019-02802-6DOI Listing
February 2019

Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw.

Clin Oral Investig 2019 Feb 4. Epub 2019 Feb 4.

Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: The aim of this study was to evaluate the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw (MRONJ).

Materials And Methods: To induce MRONJ, a total of 120 rats received intravenous zoledronate 0.06 mg/kg once a week for 6 weeks and their right mandibular first molar was extracted. Read More

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http://dx.doi.org/10.1007/s00784-019-02830-2DOI Listing
February 2019
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Relationship between the anatomic structures and mandibular posterior teeth for endodontic surgery in a Turkish population: a cone-beam computed tomographic analysis.

Clin Oral Investig 2019 Feb 2. Epub 2019 Feb 2.

Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Bolu Abant Izzet Baysal University, Bolu, Turkey.

Objective: The purpose of this study is to evaluate the relationship between anatomic structures and mandibular posterior region using cone-beam computed tomography (CBCT) in terms of endodontic surgery.

Methods: A total of 150 CBCT images were used to investigate the proximity of the anatomical structures and the mandibular posterior teeth. The buccal and lingual bone thickness overlying each root, buccolingual, and mesiodistal dimension of the roots were measured at the level of 3 mm apical resection, and the mental foramen (MF) distance to the premolar teeth and the distance of the mandibular canal (MC) to all the posterior teeth were measured. Read More

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http://dx.doi.org/10.1007/s00784-019-02834-yDOI Listing
February 2019

Impact of type of tooth on outcome of non-surgical root canal treatment.

Clin Oral Investig 2019 Feb 2. Epub 2019 Feb 2.

Department of Oral and Maxillofacial Diseases, University of Helsinki, P.O. Box 41, FI-00014, Helsinki, Finland.

Objectives: We assessed the impact of type of tooth on the outcome of root canal treatment (RCT) according to factors potentially weakening the prognosis such as preoperative apical periodontitis (AP) and treatment modality (primary or secondary RCT).

Materials And Methods: We scrutinized patient documents including pre- and postoperative radiographs of 640 permanent teeth receiving non-surgical RCT at Helsinki University Clinic in 2008-2011. Of teeth, 44% were molars, 32% premolars, and 24% anterior teeth. Read More

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http://dx.doi.org/10.1007/s00784-019-02832-0DOI Listing
February 2019

Changes in the oral health-related quality of life in adult patients with intellectual disabilities after dental treatment under general anesthesia.

Clin Oral Investig 2019 Feb 1. Epub 2019 Feb 1.

Department of Preventive Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Robert-Koch-Str. 40, D-37075, Göttingen, Germany.

Objectives: This study aimed to assess self- and proxy-rated changes in the oral health-related quality of life (OHRQoL) in adult patients with intellectual disabilities after dental treatment in general anesthesia.

Methods: The OHRQoL in 52 adult patients with intellectual and developmental disabilities was assessed prior to dental treatment in general anesthesia (t0), 2 to 3 (t1) and 12 weeks (t2) postoperatively. Therefore, patients and primary cargivers were surveyed using either the 5-item short form of the Oral Health Impact Profile translated into easy language (OHIP-G5-easy, self-rating, n = 27) or the 14-item short form of the Oral Health Impact Profile (OHIP-G14, proxy-rating, n = 51), respectively. Read More

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http://dx.doi.org/10.1007/s00784-019-02820-4DOI Listing
February 2019

Barriers and facilitators for provision of oral health care in dependent older people: a systematic review.

Clin Oral Investig 2019 Feb 1. Epub 2019 Feb 1.

Department of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Assmannshauser Str. 4-6, 14197, Berlin, Germany.

Objectives: Provision of oral health care (OHC), including oral hygiene (OH) or oral/dental treatment, to dependent older people (DOP) is frequently insufficient. We aimed to assess barriers and facilitators perceived by different healthcare professionals towards providing OHC to DOP.

Materials And Methods: A systematic review was performed. Read More

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http://dx.doi.org/10.1007/s00784-019-02812-4DOI Listing
February 2019

Response to: "Direct oral anticoagulants, vitamin K antagonists and simple single tooth extraction".

Clin Oral Investig 2019 Jan 31. Epub 2019 Jan 31.

Maxillofacial and Dental Clinic, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.1007/s00784-019-02837-9DOI Listing
January 2019
1 Read

Direct oral anticoagulants, vitamin K antagonists, and simple single tooth extraction.

Clin Oral Investig 2019 Jan 31. Epub 2019 Jan 31.

Joseph Ayo Babalola University, Ikeji-Arakeji, Nigeria.

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http://dx.doi.org/10.1007/s00784-019-02836-wDOI Listing
January 2019

The effects of extended curing time and radiant energy on microhardness and temperature rise of conventional and bulk-fill resin composites.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Gunduliceva 5, Zagreb, Croatia.

Objectives: To investigate radiant energy, microhardness, and temperature rise in eight resin composites cured with a blue or violet-blue curing unit, using a curing protocol which exceeded manufacturer recommendations.

Materials And Methods: Cylindrical composite specimens (d = 8 mm, h = 2 or 4 mm, n = 5 per experimental group) were light-cured for 30 s. Light transmittance through specimens was recorded in real time to calculate radiant energy delivered to the specimen bottom. Read More

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http://dx.doi.org/10.1007/s00784-019-02807-1DOI Listing
January 2019
2 Reads

In vitro validation of near-infrared transillumination at 780 nm for the detection of caries on proximal surfaces.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Goethestrasse 70, 80336, Munich, Germany.

Objectives: The aim of the present in vitro study was to determine the ability of Diagnocam to detect caries at an early stage and to compare it with digital radiography.

Materials And Methods: One hundred twenty proximal surfaces composed equally of sound and decayed surfaces were evaluated by assessing images captured with Diagnocam (Kavo, Biberach, Germany) and digital radiography (DR). All images were assessed twice by two calibrated dentists with a minimum interval of 2 weeks between examinations. Read More

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http://dx.doi.org/10.1007/s00784-019-02824-0DOI Listing
January 2019

Influence of buffy coat-derived putative endothelial progenitor cells on tumor growth and neovascularization in oral squamous cell carcinoma xenografts.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Interdisciplinary Head & Neck Oncology Laboratory, Department for Oral and Maxillofacial Surgery, University Hospital Giessen and Marburg, Campus Marburg, Baldingerstrasse, D-35033, Marburg, Germany.

Objectives: The aim of this murine in vivo study was to investigate whether buffy coat-derived putative endothelial progenitor cells (BC) alter tumor growth and neovascularization in oral squamous cell carcinomas (OSCC).

Materials And Methods: A murine xenograft model using the PCI-13 oral cancer cell line was deployed of which n = 24 animals received 2 × 10 BC by transfusion whereas the control group (n = 24) received NaCl (0.9%) instead. Read More

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http://link.springer.com/10.1007/s00784-019-02806-2
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http://dx.doi.org/10.1007/s00784-019-02806-2DOI Listing
January 2019
3 Reads

Calculation of postoperative bone healing of cystic lesions of the jaw-a retrospective study.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Department of Oral and Maxillofacial Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objectives: There is a long history of studies into cystic lesions of the jaws. However, there is little data on postoperative bone regeneration. The aim of the study was to calculate the size of the residual bone lesions after cystostomies and cystectomies to predict the postoperative bone healing. Read More

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http://dx.doi.org/10.1007/s00784-019-02826-yDOI Listing
January 2019
1 Read

Deproteinized bovine bone derived with collagen improves soft and bone tissue outcomes in flapless immediate implant approach and immediate provisionalization: a randomized clinical trial.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Dental Research Division, School of Dentistry, Universidade Paulista (UNIP), Av. Dr. Bacelar, 1212, 4º andar, Vila Clementino, São Paulo, SP, 04026-002, Brazil.

Objectives: This study aimed at evaluating soft and hard tissue dimensions after immediate implant placement and immediate temporization with or without alveolar preservation at the maxillary anterior region.

Materials And Methods: Twenty-two patients needing maxillary incisor extraction and with the possibility of immediate implant placement were randomly assigned to the following groups: test (n = 11): immediate implant placement + deproteinized bovine bone derived with collagen inserted into the alveolus or control (n = 11): immediate implant placement without biomaterial. All soft tissue measurements were evaluated at baseline, 3 months, and 6 months after implant therapy. Read More

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http://dx.doi.org/10.1007/s00784-019-02819-xDOI Listing
January 2019

Radiographic pattern of underlying dentin lesions (ICDAS 4) in permanent teeth.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil.

Objective: To assess the radiographic pattern of underlying dentine shadows (UDS) in the occlusal surfaces of permanent teeth.

Methods: A total of 282 permanent posterior teeth pertaining to 91 individuals, 142 UDS and 140 non-cavitated enamel lesions (NCEL), were included for comparison. UDS was defined as shadows of discolored dentin visible through the enamel surface which may or may not show signs of localized enamel breakdown, classified as code 4 by the International Caries Detection and Assessment System group. Read More

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http://dx.doi.org/10.1007/s00784-019-02818-yDOI Listing
January 2019
1 Read

Dental caries are positively associated with periodontal disease severity.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Département de dentisterie de restauration, Faculté de médecine dentaire, Université de Montréal, Montréal, Canada.

Objectives: To examine associations between periodontal disease severity and clinical and microbiological measures of caries in adults.

Materials And Methods: A cross-sectional study of 94 healthy adults ((mean ± SD) 55.4 ± 13. Read More

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http://dx.doi.org/10.1007/s00784-019-02810-6DOI Listing
January 2019
2.352 Impact Factor

Angiogenic effect of platelet-rich concentrates on dental pulp stem cells in inflamed microenvironment.

Clin Oral Investig 2019 Jan 28. Epub 2019 Jan 28.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Objective: In this study, we aimed to determine the suitable concentrations of human platelet lysate (HPL) and platelet-rich plasma (PRP) for maintaining the in vitro proliferative and angiogenic potential of inflamed dental pulp stem cells.

Materials And Methods: Lipopolysaccharide (LPS)-induced inflamed dental pulp-derived stem cells (iDPSCs) were treated with different concentrations of HPL and PRP (10% and 20%) followed by determination of viability using Alamar Blue assay. Expression of angiogenesis-, adhesion-, and inflammation-regulating genes was also analyzed using RT-qPCR array. Read More

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http://dx.doi.org/10.1007/s00784-019-02811-5DOI Listing
January 2019
2.352 Impact Factor

Experimental mucositis/gingivitis in persons aged 70 or over: microbiological findings and prediction of clinical outcome.

Clin Oral Investig 2019 Jan 26. Epub 2019 Jan 26.

Division of Periodontology, University Clinics of Dental Medicine, University of Geneva, 1 rue Michel-Servet, 1211, Geneva 4, Switzerland.

Objectives: To assess in persons aged 70 years or older the microbiological alterations occurring around implants and natural teeth during and after 3 weeks of undisturbed plaque accumulation. Furthermore, to test the predictive value of several markers at baseline for the extent of inflammation around implants and teeth after this period.

Materials And Methods: Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Read More

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http://dx.doi.org/10.1007/s00784-019-02815-1DOI Listing
January 2019
1 Read

Nuclear morphological changes in gingival epithelial cells of patients with periodontitis.

Clin Oral Investig 2019 Jan 26. Epub 2019 Jan 26.

Division for Mutagenesis, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Objectives: This study assessed the frequency of nuclear morphological changes in gingival epithelial cells, as a biomarker for DNA damage, in individuals with periodontitis, before and after implementation of periodontal therapy, and compared the morphology to those with healthy periodontal tissues.

Materials And Methods: Exfoliated gingival cells were taken from 30 participants without periodontal destruction in any teeth and 30 participants with periodontitis before and after 45 and 90 days following treatment. Nuclear morphological changes were analyzed using the micronucleus test. Read More

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http://dx.doi.org/10.1007/s00784-019-02803-5DOI Listing
January 2019
1 Read

Biological effects of acid-eroded MTA Repair HP and ProRoot MTA on human periodontal ligament stem cells.

Clin Oral Investig 2019 Jan 25. Epub 2019 Jan 25.

Cellular Therapy and Hematopoietic Transplant Unit, Hematology Department, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, Murcia, Spain.

Objective: The aim of this study was to analyze the biological effects of MTA Repair HP and ProRoot MTA on human periodontal ligament stem cells (hPDLSCs) after exposure to acidic and neutral environments.

Materials And Methods: Discs of each material (n = 30) were exposed to phosphate buffered saline (pH = 7.4) or butyric acid (pH = 5. Read More

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http://dx.doi.org/10.1007/s00784-019-02822-2DOI Listing
January 2019
2 Reads

Deep sequencing reveals specific bacterial signatures in the subgingival microbiota of healthy subjects.

Clin Oral Investig 2019 Jan 24. Epub 2019 Jan 24.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: This study aimed to define the comprehensive bacterial flora of the healthy oral cavity by identifying and comparing bacterial species in different subgingival sites using 454 sequencing of 16S rRNA genes.

Materials And Methods: Subgingival plaque samples were taken from six target teeth (central incisor, first premolar, and first molar in both the maxilla and mandible) of 10 periodontally healthy patients. Bacterial DNA was extracted and next-generation sequencing of 16S rRNA genes was performed. Read More

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http://dx.doi.org/10.1007/s00784-019-02805-3DOI Listing
January 2019
1 Read

Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Objectives: The aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.

Material And Methods: Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.

Results: Expression of FHIT (quick score 98. Read More

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http://dx.doi.org/10.1007/s00784-019-02809-zDOI Listing
January 2019
2 Reads

Fludroxycortide cream as an alternative therapy for actinic cheilitis.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Objectives: The objective of the study is to assess, by clinical follow-up, the efficacy of the dermatological cream Fludroxycortide 0.125 mg/g (Drenison®) in the treatment of actinic cheilitis (AC).

Material And Methods: Twenty-three patients diagnosed with AC participated in the study. Read More

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http://link.springer.com/10.1007/s00784-019-02823-1
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http://dx.doi.org/10.1007/s00784-019-02823-1DOI Listing
January 2019
3 Reads

Following in the footsteps of Hippocrates-interrelation between the incidence of odontogenic abscess and meteorological parameters.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Department of Oral and Maxillofacial Surgery, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Objectives: Although many physicians in daily practice assume a connection between odontogenic infections and meteorological parameters, this has not yet been scientifically proven. Therefore, the aim of the present study was to evaluate the incidence of odontogenic abscess (OA) in relation to outdoor temperature and atmospheric pressure.

Patients And Methods: An analysis of patients with an odontogenic abscess who presented at the emergency department within a period of 24 months was performed. Read More

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http://dx.doi.org/10.1007/s00784-019-02816-0DOI Listing
January 2019

N-acetyl cysteine versus chlorhexidine mouthwashes in prevention and treatment of experimental gingivitis: a randomized, triple-blind, placebo-controlled clinical trial.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA.

Objectives: To compare the efficacy of N-acetyl cysteine (NAC) mouthwash with chlorhexidine (CHX) in prevention and treatment of experimental gingivitis MATERIALS AND METHODS: Sixty subjects were assigned randomly and blindly into one of three equal groups: NAC, CHX, or placebo group. The study was conducted in two stages: preventive and treatment substudies. Professional prophylaxis was performed ahead of starting the preventive substudy. Read More

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http://dx.doi.org/10.1007/s00784-019-02813-3DOI Listing
January 2019
2.352 Impact Factor

A novel histopathological scoring system for patients with oral squamous cell carcinoma.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.

Objectives: Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters.

Materials And Methods: Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Read More

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http://dx.doi.org/10.1007/s00784-019-02804-4DOI Listing
January 2019
1 Read

Atraumatic restorative treatment-ART in early childhood caries in babies: 4 years of randomized clinical trial.

Clin Oral Investig 2019 Jan 21. Epub 2019 Jan 21.

Federal University of Rio Grande do Sul (UFRGS) School of Dentistry, Rua Ramiro Barcelos 2492, Porto Alegre, Rio Grande do Sul, 90035-003, Brazil.

Objective: To assess the effectiveness of atraumatic restorative treatment (ART) performed 4 years ago in babies suffering from early childhood caries (ECC), and to compare the clinical performance of ART atraumatic restorations performed with two different high-viscosity glass ionomer cements (GIC).

Materials And Methods: This was a longitudinal follow-up of a randomized, double-blind, split-mouth-type clinical trial. The initial sample was composed of 100 deciduous molars with occlusal lesions in 25 children with ages between 18 and 36 months who received ART with two different GICs: Ketac Molar Easymix® (3 M ESPE) and Vitro Molar® (DFL). Read More

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http://dx.doi.org/10.1007/s00784-019-02800-8DOI Listing
January 2019
3 Reads

Changes in proinflammatory gene expression in human whole blood after contact with UV-conditioned implant surfaces.

Clin Oral Investig 2019 Jan 21. Epub 2019 Jan 21.

Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University Kiel, Arnold-Heller Str. 16, 24105, Kiel, Germany.

Objectives: The aim of this in vitro study was to assess changes in the gene expression of proinflammatory cytokines in human whole blood after contact with titanium implant surfaces conditioned by UV light. To this end, expression levels of proinflammatory cytokines were analyzed in vitro in human whole blood.

Materials And Methods: Dental implants made of grade 4 titanium were conditioned by UV light in a UV device and submerged in human whole blood. Read More

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http://dx.doi.org/10.1007/s00784-019-02801-7DOI Listing
January 2019

Three dimensional maxillary growth modeling in newborns.

Clin Oral Investig 2019 Jan 11. Epub 2019 Jan 11.

Department of Dentistry, section of Orthodontics and Craniofacial Biology, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX, Nijmegen, The Netherlands.

Objectives: The aim of this study was to develop an accurate and intuitive semi-automatic segmentation technique to calculate an average maxillary arch and palatal growth profile for healthy newborns in their first year of life.

Materials And Methods: Seventy babies born between 1985 and 1988 were included in this study. Each child had five impressions made in the first year after birth that were digitalized. Read More

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http://link.springer.com/10.1007/s00784-018-2791-5
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http://dx.doi.org/10.1007/s00784-018-2791-5DOI Listing
January 2019
3 Reads

Correction to: Influence of foraminal enlargement on the healing of periapical lesions in rat molars.

Clin Oral Investig 2019 Jan 11. Epub 2019 Jan 11.

Department of Endodontics, Bahia School of Medicine and Public Health, Avenida Dom João VI, 275, Salvador, BA, 40290-000, Brazil.

Figures 2 and 3 in the published version of this article contained a mistake. CCP and DCP should have been FEG and NFEG. Correct figures are presented here. Read More

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http://dx.doi.org/10.1007/s00784-018-2780-8DOI Listing
January 2019
1 Read

Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ/ex vivo study.

Clin Oral Investig 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, PO Box 73, Bauru, SP, 17012-101, Brazil.

Objectives: The aim of this study was to investigate the effect of a dentifrice that contains calcium silicate, sodium phosphate, and fluoride on erosive-abrasive enamel wear.

Material And Methods: This randomized, single-blind in situ/ex vivo study was conducted with four crossover phases of 5 days (one group tested per phase). Bovine enamel blocks (n = 256) were allocated to 16 volunteers and 8 groups. Read More

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http://dx.doi.org/10.1007/s00784-018-2792-4DOI Listing
January 2019
1 Read

Association between perioperative oral care and postoperative pneumonia after cancer resection: conventional versus high-dimensional propensity score matching analysis.

Clin Oral Investig 2019 Jan 8. Epub 2019 Jan 8.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Objectives: Perioperative oral care was reported to decrease postoperative pneumonia after cancer resections. However, the effect remains controversial because previous studies were limited due to their small sample sizes and lack of strict control for patient backgrounds. The present study evaluated the association between perioperative oral care and postoperative pneumonia using high-dimensional propensity score (hd-PS) matching to adjust for confounding factors. Read More

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http://link.springer.com/10.1007/s00784-018-2783-5
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http://dx.doi.org/10.1007/s00784-018-2783-5DOI Listing
January 2019
5 Reads

Perceived helpfulness of treatments for myofascial TMD as a function of comorbid widespread pain.

Clin Oral Investig 2019 Jan 8. Epub 2019 Jan 8.

Department of Oral & Maxillofacial Pathology, Radiology & Medicine, New York University College of Dentistry, 380 2nd Avenue, Suite 301, New York, NY, 10010, USA.

Objective: This study examined whether patients with myofascial temporomandibular disorder (mTMD) comorbid with fibromyalgia (FM) receive different treatments or respond differently to these treatments than mTMD-only patients.

Materials And Methods: A total of 125 mTMD+ women were enrolled (26 FM+ and 98 FM-). mTMD and FM were assessed via clinical research examinations. Read More

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http://dx.doi.org/10.1007/s00784-018-02797-6DOI Listing
January 2019
2 Reads

The role of immediate versus secondary removal of the odontogenic focus in treatment of deep head and neck space infections. A retrospective analysis of 248 patients.

Clin Oral Investig 2019 Jan 8. Epub 2019 Jan 8.

Department of Oral & Maxillofacial Plastic Surgery, University hospital Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany.

Objectives: Aim of this study was to investigate conditions and predisposing factors for head and neck infection progress regarding the length of stay (LOS) in hospital, with special emphasis on the time of removal of the odontogenic infection focus.

Material And Methods: A 3-year retrospective study reviewed hospital records of 248 subjects who were treated under inpatient conditions with severe odontogenic infections who received surgical incisions, drainage, and intravenous (IV) antibiotics. Outcomes measured included age, gender, involved fascial spaces, LOS, number of infected spaces, antibiotics administered, and comorbidities. Read More

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http://dx.doi.org/10.1007/s00784-018-02796-7DOI Listing
January 2019
1 Read

Histologic analyses of flapless ridge preservation in sockets with buccal dehiscence defects using two alloplastic bone graft substitutes.

Clin Oral Investig 2019 Jan 8. Epub 2019 Jan 8.

Clinic for Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, CH-8032, Zurich, Switzerland.

Objectives: To investigate whether one of two synthetic bone substitute materials used for ridge preservation in the extraction sockets with buccal dehiscence defects was superior regarding new bone formation and ridge preservation and to compare it to sites left for spontaneous healing.

Materials And Methods: In sixteen dogs, P3 and P4 were hemi-sectioned and the respective distal roots were extracted. Following the preparation of a mucoperiosteal flap without vertical releasing incisions, 50% of the buccal bone was carefully removed. Read More

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http://link.springer.com/10.1007/s00784-018-2784-4
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http://dx.doi.org/10.1007/s00784-018-2784-4DOI Listing
January 2019
2 Reads

Comparison of the hospitalization period after microvascular reconstruction flap in trismus patients: free anterolateral thigh flap versus free forearm flap.

Clin Oral Investig 2019 Jan 7. Epub 2019 Jan 7.

Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, 2F, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei City, 114, Taiwan, Republic of China.

Objectives: The primary strategy for treating oral squamous cell carcinoma (OSCC) is therapeutic resection, with the trismus resection defect reconstructed via free flap. The most popular free flaps include the radial forearm free flap (RFFF) and anterolateral thigh free flap (ALT). This study investigated the relationships between the hospitalization period and a variety of surgical outcomes, as well as maximum inter-incisor distance (IID), in trismus patients who chewed betel nuts. Read More

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http://link.springer.com/10.1007/s00784-018-02799-4
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http://dx.doi.org/10.1007/s00784-018-02799-4DOI Listing
January 2019
7 Reads

Sinus augmentation analysis of the gradient of graft consolidation: a split-mouth histomorphometric study.

Clin Oral Investig 2019 Jan 7. Epub 2019 Jan 7.

Department of Periodontology, the Maurice and Gabriela Goldschleger School of Dental Medicine, The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Objective: The aim of this study was to histomorphometrically test the hypothesis that graft consolidation originates from the sinus floor.

Materials And Methods: This prospective, randomized split-mouth study investigated patients undergoing bilateral maxillary lateral sinus floor augmentation using either freeze-dried bone allografts (FDBAs) or biphasic calcium phosphate (BCP) bone substitute. Apico-coronal core biopsies were harvested during implant placement 9 months after sinus floor augmentation, processed for histological observation, and measured histomorphometrically. Read More

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http://link.springer.com/10.1007/s00784-018-2793-3
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http://dx.doi.org/10.1007/s00784-018-2793-3DOI Listing
January 2019
2 Reads

Clinical investigation of gustatory and neurosensory alterations following mandibular third molar surgery: an observational prospective study.

Clin Oral Investig 2019 Jan 6. Epub 2019 Jan 6.

Division of Oral and Maxillofacial Surgery, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Brazil.

Objective: This study aimed to prospectively observe gustatory and neurosensory alterations following surgical removal of mandibular third molars.

Material And Methods: A prospective clinical study was conducted with patients who required mandibular third molar extraction, recruited from the Division of Oral and Maxillofacial Surgery at the Federal University of Ceará (Brazil). Age, sex, and radiographic signs were recorded. Read More

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http://dx.doi.org/10.1007/s00784-018-02798-5DOI Listing
January 2019
2 Reads

Randomized clinical trial of class II restoration in permanent teeth comparing ART with composite resin after 12 months.

Clin Oral Investig 2019 Jan 6. Epub 2019 Jan 6.

Department of Dental Materials, Endodontics and Operative Dentistry, Bauru School of Dentistry, Bauru, Brazil.

Objective: This study evaluated the effectiveness of class II restorations, in permanent teeth, through the ART technique in comparison to composite resin.

Materials And Methods: Participants (154), aged 8 to 19 years, with good general health, with class II cavities in permanent teeth, and without pulp involvement and tooth pain were included in this parallel and randomized clinical trial. The Ethics Committee approval number was CAAE: 24012913. Read More

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http://dx.doi.org/10.1007/s00784-018-2787-1DOI Listing
January 2019
1 Read

Genotoxic effects in oral mucosal cells caused by the use of orthodontic fixed appliances in patients after short and long periods of treatment.

Clin Oral Investig 2019 Jan 5. Epub 2019 Jan 5.

Department of Pediatric Clinic, School of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café, s/n Monte Alegre, Ribeirão Preto, SP, 14040-904, Brazil.

Objective: This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does not cause genotoxic effects in patients.

Material And Methods: An observational cross-sectional study including 74 patients enrolled in corrective orthodontic treatment and 21 control patients, between 11 and 35 years of age, of both genders, participated in the research. Read More

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http://dx.doi.org/10.1007/s00784-018-02795-8DOI Listing
January 2019
2 Reads