2,550 results match your criteria Clinical laboratory[Journal]


Identification of a Novel Gene Mutation in a Chinese Pedigree with X-linked Thrombocytopenia.

Clin Lab 2018 Oct;64(11)

Background: X-linked thrombocytopenia (XLT) is a milder form of Wiskott-Aldrich syndrome (WAS), characterized predominantly by thrombocytopenia with small-sized platelets. Mutations in the WAS gene are responsible for the disease. We herein detected a new mutation in the WAS gene responsible for XLT in a 3-generation Chinese pedigree. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180837DOI Listing
October 2018
4 Reads

Thiol-Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis.

Clin Lab 2018 Oct;64(11)

Background: The objective of this study is to examine thiol-disulfide homeostasis in patients with cerebral venous sinus thrombosis.

Methods: Fifty-three patients diagnosed with cerebral venous sinus thrombosis and 80 healthy volunteers were included in the study. The native thiol and total thiol concentrations were measured with the newly developed automated method. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180707DOI Listing
October 2018
2 Reads
1.084 Impact Factor

Effect of lncRNA BNC2-AS1 on the Proliferation, Migration and Invasion of Gastric Cancer Cells.

Clin Lab 2018 Oct;64(11)

Background: Gastric cancer is one of the most common cancers and is the second leading cause of cancer mortality worldwide. The present study aimed to investigate the potential biological effect of long non-coding RNA (lncRNA) BNC2-AS1 on the proliferation, migration, and invasion of cervical cancer cells. Methods: BNC2-AS1 small interfering RNA (siRNA) was transfected into SGC7901 and BGC823 gastric cancer cell lines, with negative siRNA serving as a control. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180537DOI Listing
October 2018
8 Reads

Detection and Evaluation of Escherichia coli O157:H7 and Shiga-toxin Genes stx1, stx2 in Cattle Meat Samples.

Clin Lab 2018 Oct;64(11)

Background: Screening of transmission routes and routine control of the food for foodborne-pathogens are vital in terms of public health. In this study, we aimed to investigate and evaluate the presence of E. coli O157:H7 strains and toxins in the cattle meat samples collected from different markets and butchers. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180323DOI Listing
October 2018
11 Reads

Association Between the Polymorphism in miR-605 and Cancer Susceptibility: a PRISMA-Compliant Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: MicroRNAs (miRNAs) play important roles in cancer development. miR-605 was reported in several studies and showed potential as a prognostic biomarker. However, the association between miR-605 and the risk of cancer remained controversial in previous studies. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180545DOI Listing
October 2018
1 Read

A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node.

Clin Lab 2018 Oct;64(11)

Background: Castleman disease (CD) is a lymphoproliferative disorder and Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage system. The authors describe a rare case of CD coexistent with LCH at diagnosis in one lymph node. Methods: Hematologic investigation and intrapulmonary mass biopsy were performed. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180547DOI Listing
October 2018
10 Reads
1.084 Impact Factor

Estimated Total Albumin in Fresh Urine Samples Based on Correlation Between the Roche Immunoturbidimetric and an In-House HPLC Method.

Clin Lab 2018 Oct;64(11)

Background: Many studies have reported higher values of urinary albumin measured by high performance liquid chromatography (HPLC) in comparison with immunochemical methods. The aims of our study were the implementation of the HPLC method for albuminuria, testing the hypothesis about coeluting proteins, comparison of albuminuria assessed by HPLC and immunoturbidimetric (IT) methods in diabetic and non-diabetic patient samples. Methods: We compared albuminuria assessed by HPLC with albuminuria assessed by the IT method in fresh urine samples of 636 diabetics and 456 non-diabetics. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180410DOI Listing
October 2018
1 Read

Clinical Laboratory Reference Intervals in Ethiopia: Current Status and Future Considerations: Review.

Clin Lab 2018 Oct;64(11)

Background: Clinical laboratory reference intervals are derived from a sample of selected healthy population and they are used for disease diagnosis, management, and monitoring. International guidelines recommended that laboratories and manufacturers are supposed to establish their own RIs for a certain group of population. Therefore, the aim of this narrative review is to summarize the current status and to show future directions regarding reference intervals of clinical laboratory parameters among Ethiopian population. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180544DOI Listing
October 2018
1 Read
1.084 Impact Factor

Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.

Clin Lab 2018 Oct;64(11)

Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180543DOI Listing
October 2018
10 Reads

Long Non-Coding RNA TUG1 as a Potential Novel Biomarker for Predicting the Clinical Outcome of Cancer Patients: a Meta-Analysis.

Clin Lab 2018 Oct;64(11)

Background: Emerging evidence suggests that long non-coding RNAs (lncRNAs) can be used as potential biomarkers for a wide range of cancers. Herein, the prognostic value of lncRNA taurine upregulated gene (TUG1) was analyzed using meta-analysis in different kinds of cancers. Methods: Databases including Cochrane Library, PubMed, and Chinese National Knowledge Infrastructure were searched for epidemiological studies up to March 2018. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180520DOI Listing
October 2018
1 Read

Sporothrix Schenckii Infection.

Clin Lab 2018 Oct;64(11)

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http://dx.doi.org/10.7754/Clin.Lab.2018.180628DOI Listing
October 2018
1 Read

Changes in Prealbumin and Body Mass Index Associated with T Lymphocyte Subsets and Nutritional Status in Chronic Hepatitis B and HBV-Cirrhosis Patients.

Clin Lab 2018 Oct;64(11)

Background: Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. Methods: T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals. Read More

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http://www.clin-lab-publications.com/article/2877
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http://dx.doi.org/10.7754/Clin.Lab.2018.180501DOI Listing
October 2018
4 Reads

Assessment of Serum Vitamin D and Irisin Levels in Obese Patients.

Clin Lab 2018 Oct;64(11)

Background: 25-hydroxyvitamin D and irisin have been found to be involved in the pathogenesis of obesity. The aim of the study is to assess the serum levels of 25-hydroxyvitamin D and irisin in obese patients and to determine the association of 25-hydroxyvitamin D and irisin levels with anthropometric parameters. Methods: The study was carried out on 300 obese patients in addition to 156 healthy age and gender matched subjects as a control group. Read More

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http://www.clin-lab-publications.com/article/2876
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http://dx.doi.org/10.7754/Clin.Lab.2018.180416DOI Listing
October 2018
2 Reads

Does Adenovirus and Coxsackie B Virus Infection Play a Role in Tracheobronchopathia Osteochondroplastica (TO).

Clin Lab 2018 Oct;64(11)

Background: Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease. We report a case of TO. Methods: Chest CT scan and bronchoscope with biopsy was performed for diagnosis and blood tests explored for the latent etiology. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180618DOI Listing
October 2018
2 Reads

Serum Cryptococcal Antigen Confirmed Pulmonary Cryptococcosis in an Immune-competent Adult Firstly Misdiagnosed of Tuberculosis from a Lung Biopsy: a Case Report and Literature Review.

Clin Lab 2018 Oct;64(11)

Background: Cryptococcal pneumonia is an uncommon lesion in immune-competent adults. Histological evidence of Cryptococcus neoformans is a gold criterion for diagnosis. Here we report a case firstly misdiagnosed as tuberculosis from a lung biopsy. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180616DOI Listing
October 2018
19 Reads

LBH mRNA Expression and Polymorphisms in Patients with Rheumatoid Arthritis.

Clin Lab 2018 Oct;64(11)

Background: This study was performed to determine the mRNA expression levels of limb-bud and heart (LBH) in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis (RA), and to assess the associations of LBH rs7579944 and rs906868 polymorphisms with RA in a Chinese population. Methods: Real-time transcription-polymerase chain reaction analysis was used to determine the LBH mRNA expression in PBMCs from 53 patients with RA and 58 healthy controls, and LBH rs7579944 and rs906868 polymorphisms were genotyped in 328 RA patients and 449 healthy controls. Results: The LBH mRNA expression levels were significantly decreased in RA patients compared with healthy controls (p = 0. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180603DOI Listing
October 2018
5 Reads

Live Confocal Visualization of FXIII Activity.

Clin Lab 2018 Oct;64(11)

In addition to its important functions in angiogenesis, wound healing, bone biology, immunology, pregnancy, and adipogenesis, transglutaminase factor XIII is an outstanding determinant of clot characteristics. Factor XIII mediates clot stability by covalent cross-linking of fibrin-fibrils and inhibition of fibrinolysis. For decades it was assumed that factor XIII mediates the formation of a 3-dimensional net structure of the clot. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180601DOI Listing
October 2018
3 Reads

The Generation of Hematopoietic Progenitor Cells from Endothelial Cells by Silymarin.

Clin Lab 2018 Oct;64(11)

Background: The generation of hematopoietic cells from endothelial cells may determine a novel approach for the production of blood cells. Regenerative functions of Silymarin, a mixture of polyphenolic flavonoids derived from milk thistle, have previously been reported. The purpose of this study was to investigate the direct effect of Silymarin on conversion of endothelial cells to hematopoietic cells. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180534DOI Listing
October 2018
1 Read
1.084 Impact Factor

Evaluation of the Elecsys Syphilis Assay as a Laboratory Screening Test for Syphilis.

Clin Lab 2018 Oct;64(11)

Background: The sexually transmitted infection (STI) syphilis remains a public health problem globally. The serological detection of specific antibodies to Treponema pallidum is particularly important in the diagnosis of syphilis. The purpose of this study was to evaluate the newly developed Elecsys Syphilis assay and compare it with the local market well-established ARCHITECT Syphilis TP assay. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180301DOI Listing
October 2018
2 Reads

Early Detection of Colorectal Cancer: a Multi-Center Pre-Clinical Case Cohort Study for Validation of a Combined DNA Stool Test.

Clin Lab 2018 Oct;64(10):1719-1730

Background: Although colonoscopy-based screening has proven to be highly effective in detecting colorectal cancer (CRC), participation rates remain disappointing. Development of CRC is associated with a number of genetic or somatic mutations. New, non-invasive stool tests are currently being developed based on the detection of these alterations. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180521DOI Listing
October 2018
13 Reads

The Dynamic Trends of Urinary LH and FSH Assayed by ICMA During Triptorelin Stimulation Tests in Girls - a Pilot Study.

Clin Lab 2018 Oct;64(10):1701-1708

Background: Gonadotropin-releasing hormone stimulation test is a gold standard for evaluating the function of the hypothalamic-pituitary-gonadal axis (HPGA) in children. These tests are usually uncomfortable because of multi-venipunctures. A urine specimen is a good alternative because it is noninvasive and convenient. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180514DOI Listing
October 2018
1 Read

Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network.

Clin Lab 2018 Oct;64(10):1661-1669

Background: Gastric cancer is one of the most common malignant tumors worldwide. Increasing studies have indicated that non-coding RNAs (ncRNAs) play critical roles in cancer progression. They have shown great potential to be useful markers and therapeutic targets. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180419DOI Listing
October 2018
2 Reads

The Effect of Over-Expression of miR-20a on Cell Proliferation of Human T Cell Leukemia Cell Line.

Clin Lab 2018 Oct;64(10):1641-1647

Background: Acute T Cell Leukemia (ALL) is an aggressive and prevalent human malignancy. Chemotherapy is the most frequent therapeutic strategy; however, cytotoxicity and recurrence of cancer are the main concerns. The discovery of microRNA (miRNA) drew the attention of scientists who were working on targeted cancer therapy to use the potential of gene regulation by using this small RNAs. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180406DOI Listing
October 2018
10 Reads

Could Insulin and Hemoglobin A1c Levels be Predictors of Hunger- Related Malnutrition/Undernutrition Without Disease?

Clin Lab 2018 Oct;64(10):1635-1640

Background: Malnutrition results in functional changes in the liver and pancreas that negatively affect carbohydrate metabolism. The aim of this study was to evaluate whether insulin hormone and glycated hemoglobin A1c (HbA1c) could serve as predictors of hunger-related malnutrition/undernutrition without disease in adults.

Methods: The Malnutrition Universal Screening Tool (MUST) was used to assess malnutrition in this single-center, cross-sectional study. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180403DOI Listing
October 2018
16 Reads

Multianalyte Determination of NOACs Using LC-MS/MS and Comparison with Functional Coagulation Assays.

Clin Lab 2018 Oct;64(10):1611-1621

Background: Detection of new oral anticoagulant (NOAC) levels by screening, special and global tests, and liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) is important in clinical situations when the cause of bleeding needs to be determined.

Methods: We compared a routine coagulation test, special function test for NOACs, global coagulation test, and an LC-MS/MS method that enables simultaneous determination of apixaban, dabigatran and rivaroxaban in human plasma within one analysis to determine the optimal indication of the comparison methods, including their limitations and interferences.

Results: This study was conducted on a set of blood samples from 116 patients treated with NOACs. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180335DOI Listing
October 2018
8 Reads

The Link Between Selenium, Oxidative Stress and Pregnancy Induced Hypertensive Disorders.

Clin Lab 2018 Oct;64(10):1593-1610

Background: The first line of defence against oxidative stress (OS) are the endogenous antioxidants, such as the Se containing compounds. During pregnancy, OS is caused by the intense growth activity of the fetus; therefore, the placenta is a key place for the activity of many seleno-compounds such as glutathione-peroxidase and thioredoxinreductase.

Methods: This review aims to establish the link between the type of selenium compounds, their concentration, their metabolic pathways, and their role in both physiologic and pathologic processes during pregnancy. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180307DOI Listing
October 2018
16 Reads

MiR-33 may be a Biological Marker for Coronary Heart Disease.

Clin Lab 2018 Oct;64(10):1755-1760

Background: The main aim of this study was to evaluate the expression and specific role of miR-33 in the progression of coronary heart disease (CAD), thereby evaluating their diagnostic ability and use in treatment in CAD patients.

Methods: Real time PCR was carried out to explore the level of miR-33 in the plasma of CAD patients and controls. ELISA was performed to analyze the level of placenta growth factor fragment (PLGF). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180538DOI Listing
October 2018
6 Reads

Prognostic Value of ALT, AST, and AAR in Hepatocellular Carcinoma with B-Type Hepatitis-Associated Cirrhosis after Radical Hepatectomy.

Clin Lab 2018 Oct;64(10):1739-1747

Background: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST to ALT ratio (AAR) were shown to be associated with prognosis in some groups of hepatocellular carcinoma (HCC). However, their clinicopathologic and prognostic roles in HCC patients with B-type hepatitis-associated cirrhosis (HBAC) have not been comprehensively investigated. The present study aimed to address the issues. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180532DOI Listing
October 2018
1 Read

A Case Report of 46, XX Sex Reversal Syndrome.

Clin Lab 2018 Oct;64(10):1765-1767

Background: Sex reversal syndrome (SRS) is a human chromosomal abnormality disease with gender dysplasia, which is characterized by inconsistency between social sexuality and genetic sexuality.

Methods: We report a case of sex reversal syndrome with 46, XX. Chemiluminescence was used to detect serum sex hormones, including testosterone (T), luteinizing hormone (LH), and follicular stimulation (FSH), and 15 karyotype analysis. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180529DOI Listing
October 2018
1 Read

Association Study Between MTRR, TAF4B, PIWIL1 Variants and Non-Obstructive Azoospermia in Northeast Chinese Han Population.

Clin Lab 2018 Oct;64(10):1731-1738

Background: Non-obstructive azoospermia (NOA) is an important factor leading to male infertility and the genetic mechanism is not yet clear. It requires investigation to reveal its occurrence based on sequencing technology from the genetic level. Our previous genome wide association study (GWAS) using targeted high-throughput sequencing technology has identified suspected genetic variants including rs162036, rs161870, rs1677016R and rs1106042R associated with non-obstructive azoospermia (data not published). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180525DOI Listing
October 2018
8 Reads

Five Fibrosis Biomarkers Together with Serum Ferritin Level to Diagnose Liver Fibrosis and Cirrhosis.

Clin Lab 2018 10;64(10):1685-1693

Background: Liver fibrosis is a dynamic procedure that results from an irregularity between fibrogenesis and fibrolysis. After time this procedure can lead to cirrhosis of the liver. Liver fibrosis and cirrhosis assessment is very important for both therapeutic decisions and prognostic evaluations. Read More

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http://www.clin-lab-publications.com/article/2847
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http://dx.doi.org/10.7754/Clin.Lab.2018.180502DOI Listing
October 2018
3 Reads
1.084 Impact Factor

Study on the Correlation Between Urinary Transferrin and Nonalcoholic Fatty Liver Disease.

Clin Lab 2018 Oct;64(10):1655-1660

Background: Nonalcoholic fatty liver disease (NAFLD) can cause renal injury, and urinary transferrin (UTRF) is extremely sensitive to renal injury. We aimed to investigate the correlation between UTRF and NAFLD and to observe the distribution of NAFLD at different levels of UTRF.

Methods: A total of 711 subjects fulfilled the diagnostic criteria of NAFLD and 1,396 healthy control participants were enrolled in this study. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180417DOI Listing
October 2018
8 Reads

Polyparasitism of Rhabditis Axei and Enterobius Vermicularis in a Child from Beijing, China.

Clin Lab 2018 Oct;64(10):1773-1776

Background: Rhabditis (Rhabditellae) axei is a common species in soil, which has been reported repeatedly in human urine and the digestive system. Humans exposed to sewage or mistakenly polluted sewage is the cause of larvae infecting the digestive tract or via the urethra. We reported a patient infected with Rhabditis axei and Enterobius Vermicularis. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180540DOI Listing
October 2018
14 Reads
1.084 Impact Factor

Primary Cutaneous Nocardia brasiliensis in a Spanish Child.

Clin Lab 2018 Oct;64(10):1769-1772

Background: We report a case of a primary cutaneous nocardiosis by autochthonous Nocardia brasiliensis in a Spanish immunocompetent 9-year-old boy.

Methods: N. brasiliensis caused cellulitis showing the patient recovery after drainage and treatment with trimethoprim-sulfamethoxazole. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180531DOI Listing
October 2018
13 Reads

Comparison of IgG4-Related Lymphadenopathy and Multicentric Castleman's Disease: a Retrospective Study.

Clin Lab 2018 Oct;64(10):1671-1678

Background: It can be difficult to distinguish between IgG4-related lymphadenopathy and multicentric Castleman's disease (MCD) because these conditions cannot be differentially diagnosed using immunohistochemical staining alone. In this study, we analyzed the clinical features of IgG4-related lymphadenopathy and MCD patients.

Methods: We retrospectively analyzed 27 patients with MCD, including 20 with plasma cell-type (PC-type) and 7 with hyaline vascular (HV) features (mixed-type). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180421DOI Listing
October 2018
3 Reads

Serum High-Sensitivity C Reactive Protein Improves Sensitivity of CURB-65 in Predicting ICU Admission and Mortality in Community-Acquired Pneumonia Patients.

Clin Lab 2018 Oct;64(10):1749-1754

Background: The CURB-65 scoring system is a simple tool in assessment and prognosis prediction for communityacquired pneumonia (CAP) patients. However, the variations in performance of CURB-65 in young and elderly patients, underestimation or overestimation of the severity, and mortality have often been reported. The aim of this study was to investigate the usefulness of serum high-sensitivity C reactive protein (hs-CRP) combined with CURB-65 in predicting ICU admission and 30-day mortality in CAP patients. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180536DOI Listing
October 2018
11 Reads

Rapidly Progressive, Fata Infection Caused by Bacillus Cereus in a Patient with Acute Lymphoblastic Leukemia.

Clin Lab 2018 Oct;64(10):1761-1764

Background: We herein report a fatal case of fulminant septicemia caused by Bacillus cereus in a 49-year-old female with T-cell acute lymphoblastic leukemia receiving chemotherapy.

Methods: Her two blood culture sets were positive for Gram-positive, rod-shaped bacterium. Bacillus cereus was identified by high-throughput MALDI-TOF mass spectrometry and 16S ribosomal RNA gene sequencing. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180528DOI Listing
October 2018
2 Reads
1.084 Impact Factor

Reduced Seroprevalence of Hepatitis A Virus Among Japanese Healthcare Workers as a Risk Factor for Occupational Infection.

Clin Lab 2018 Oct;64(10):1791-1793

Background: With the improvement in sanitation and hygiene, the incidence of hepatitis A virus (HAV) infection has declined, and its seroprevalence among Japanese people has been reduced. Universal HAV vaccination is yet to be implemented in Japan, and the healthcare workers (HCWs) are at higher risks of acquiring this infection. We herein report the seroepidemiology of HAV infection among HCWs at Osaka University Hospital. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180518DOI Listing
October 2018
8 Reads

The Observation and Analysis of Internal Quality Control of Cystatin C in China from 2014 to 2017.

Clin Lab 2018 Oct;64(10):1709-1718

Background: This study observed and analyzed the internal quality control (IQC) of cystatin C (CysC) so that we can have overall knowledge about imprecision levels in Chinese medical laboratories.

Methods: Using the software developed by the National Center for Clinical Laboratories (NCCL), we can get the IQC information of CysC from 2014 to 2017. Then the proportion of laboratories meeting five quality specifications (pass rates) were calculated and the current CVs (coefficient of variation) were also compared among subgroups and years. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180515DOI Listing
October 2018
2 Reads
1.080 Impact Factor

Assessment of Plasma Amino Acid Dynamics in Response to ACTH Stimulation by Liquid Chromatography Tandem-Mass Spectrometry.

Clin Lab 2018 Oct;64(10):1695-1700

Background: The adrenocorticotropic hormone (ACTH) stimulation test is a widely used diagnostic tool to assess the adrenal gland function. Beyond that the ACTH test can be used in stress research to induce a biochemical stress response under standardized conditions. To study the impact of the stress response on protein metabolism, time-course plasma amino acid profiling in healthy individuals was performed with high performance liquid chromatography tandem-mass spectrometry (HPLC-MS/MS). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180513DOI Listing
October 2018
11 Reads

Heterozygous FUT1 Mutations Causing a Para-Bombay Phenotype.

Clin Lab 2018 Oct;64(10):1787-1789

Background: To study a case of para-Bombay phenotype caused by compound heterozygous mutation of the FUT1 gene.

Methods: We performed an agglutination examination to anti-H serum. Secretor status was determined in order to assess the presence of soluble blood group substances. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180428DOI Listing
October 2018
15 Reads