2,642 results match your criteria Clinical laboratory[Journal]


Associations between Vitamin D and β-Cell Function and Colorectal Cancer-Associated Tumor Markers in Chinese Type 2 Diabetic Patients with Albuminuria.

Clin Lab 2019 Apr;65(4)

Background: This study is to investigate the protective effects of vitamin D in T2DM, as well as the associations between serum calcifediol level and β-cell function, and risk of CRC, in Chinese type 2 diabetes mellitus (T2DM) patients with albuminuria.

Methods: Serum calcifediol levels were analyzed and compared among healthy individuals and T2DM patients stratified by albumin/creatinine ratio (ACR). Relative correlation analyses were performed with β-cell function (BCF) and risk of CRC. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.181111DOI Listing
April 2019
3 Reads

Expression and Clinical Significance of Serum miR-497 in Patients with Acute Cerebral Infarction.

Clin Lab 2019 Apr;65(4)

Background: There are no effective serum biomarkers for early diagnosis and prognosis prediction of acute cerebral infarction (ACI). This study is to explore the roles of miR-497 in the prognosis of patients with ACI and the correlation between miR-497 and some cytokines.

Methods: MiR-497 expression in 90 serum samples from ACI patients compared to 60 normal control samples subjects was determined by real-time PCR. Read More

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http://www.clin-lab-publications.com/article/2987
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http://dx.doi.org/10.7754/Clin.Lab.2018.181001DOI Listing
April 2019
2 Reads

Serum miR-3142 could be Used as a Potential Biomarker to Screen Cervical Cancer Patients from Healthy Controls.

Clin Lab 2019 Apr;65(4)

Background: The current study aims to evaluate the expression of miR-3142 in the serum of cervical cancer patients and healthy controls, thereby exploring the role of miR-3142 in the diagnosis and prognosis prediction of cervical cancer.

Methods: Real time PCR analysis was carried out to evaluate the expression of miR-3142 in the serum and tissues of cervical cancer patients. The diagnostic threshold and the area under the curve (AUC) were analyzed by receiver operating characteristic curve (ROC) and the survival analysis was performed by Kaplan-Meier. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180925DOI Listing
April 2019
1 Read

Performance Evaluation of the Mindray BC 6800 Hematology Analyzer and Flag Comparison with the XE-2100 and Manual Microscopy.

Clin Lab 2019 Apr;65(4)

Background: The Mindray BC-6800 automated hematology analyzer is an automated hematology analyzer and 5-part leukocyte differential counter for in vitro diagnostic use in clinical laboratories. It is necessary to undergo an evaluation before the instrument is used to test patient samples.

Methods: The performance was evaluated with regards to precision, linearity, carry-over, and method comparison. Read More

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http://www.clin-lab-publications.com/article/2985
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http://dx.doi.org/10.7754/Clin.Lab.2018.180923DOI Listing
April 2019
4 Reads

Comparison of Hydrostatic Filtration Dialysis with Ultracentrifugation Methods for the Identification and Proteomic Profiling of Urinary Extracellular Vesicles.

Clin Lab 2019 Apr;65(4)

Background: Urinary extracellular vesicles (UEVs) carry rich markers of their parent cells, so they can serve as possible biomarkers of kidney diseases.

Methods: In this study, we isolated urinary extracellular vesicles from five individuals using a simple, clinically applicable method called hydrostatic filtration dialysis (HFD) and compared it to the gold-standard ultracentrifuga-tion (UC) with transmission electron microscopy (TEM). We also employed a proteomic approach using pooled human urine samples from the same five individuals to profile the protein composition of UEVs to evaluate the effectiveness of these two methods. Read More

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http://www.clin-lab-publications.com/article/2984
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http://dx.doi.org/10.7754/Clin.Lab.2018.180922DOI Listing
April 2019
4 Reads

Alterations in the Iron Homeostasis Network of Hepatocytes Caused by Hepatitis B Virus.

Clin Lab 2019 Apr;65(4)

Background: It is unclear whether hepatitis B virus (HBV) itself causes iron metabolism disorder in patients with chronic hepatitis B (CHB). In this study, we investigated the effect of HBV on iron metabolism at the clinical and cellular levels to determine the pathogenesis of CHB.

Materials: We enrolled 41 CHB patients and 20 healthy controls (HCs) in a retrospective study. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180914DOI Listing
April 2019
1.084 Impact Factor

The Prevalence of Mixed Genotype Infections in Turkish Patients with Hepatitis C: a Multicentered Assessment.

Clin Lab 2019 Apr;65(4)

Background: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genotype and sub-type distributions by a multicentered assessment.

Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180824DOI Listing
April 2019
1 Read

Analytical Performance of a New Immunoturbidimetric Assay for von Willebrand Factor (VWF) Activity Testing.

Clin Lab 2019 Apr;65(4)

Background: Von Willebrand disease requires laboratory confirmation with quantitative and qualitative measurements of von Willebrand factor (VWF). Qualitative VWF-activity (VWF-Ac) tests have poor inter- and intra-laboratory reproducibility with coefficients of variation (CVs) as high as 64%, often lacking accuracy at low VWF-Ac levels.

Methods: This study evaluated the recently launched immunoturbidometric STAGO® STA-VWF:RCo® reagent for VWF-Ac. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180919DOI Listing
April 2019
3 Reads

The Role of Neutrophil to Lymphocyte Count Ratio in the Differential Diagnosis of Pulmonary Tuberculosis and Bacterial Community-Acquired Pneumonia: a Cross-Sectional Study at Ayder and Mekelle Hospitals, Ethiopia.

Clin Lab 2019 Apr;65(4)

Background: The differential diagnosis of pulmonary tuberculosis and bacterial community-acquired pneumonia is often a challenging phenomenon. The neutrophil to lymphocyte count ratio, a suitable indicator of inflammation, has been demonstrated to be a useful biomarker for predicting bacteremia. The main aim this study is to evaluate the role of neutrophil to lymphocyte count ratio in the differential diagnosis of pulmonary tuberculosis and bacterial Community-Acquired Pneumonia at Ayder and Mekelle hospitals, Mekelle, Ethiopia. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180833DOI Listing
April 2019
1 Read

Improving the Detection of Urine Sediment with a Modified Urinalysis Review Procedure.

Clin Lab 2019 Apr;65(4)

Background: Currently, numerous review procedures are applied to perform the urine sediment examination. Clinical technologists and nephrologists use different procedures for the determination of specimen concentration and for particle counting. These techniques may underestimate the formed elements such as pathological casts (CASTs) and renal tubular epithelial (RTE) cells and might interfere with clinical diagnosis. Read More

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http://www.clin-lab-publications.com/article/2979
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http://dx.doi.org/10.7754/Clin.Lab.2018.180830DOI Listing
April 2019
2 Reads

Circulating miR-625 as an Emerging Biomarker for Liver Cirrhosis.

Clin Lab 2019 Apr;65(4)

Background: Sensitive and specific diagnostic indicators are essential for liver cirrhosis. This study aims to analyze two plasma microRNAs (miR-625 and miR-920) as possible biomarkers for liver cirrhosis.

Methods: miR-625 and miR-920 expressions were analyzed in the plasma of 40 patients with liver cirrhosis and 41 healthy controls. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180704DOI Listing
April 2019
4 Reads

The Relationship between Bilirubin Levels and Patients with Lupus Nephritis.

Clin Lab 2019 Apr;65(4)

Background: Bilirubin acts as an antioxidant. In this study, we assessed the relationship between the bilirubin level and lupus nephritis (LN).

Methods: We included 50 newly diagnosed LN patients and 74 healthy individuals. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.181125DOI Listing
April 2019
1 Read

Clinical Value of Serum HE4, CA125, CA72-4, and ROMA Index for Diagnosis of Ovarian Cancer and Prediction of Postoperative Recurrence.

Clin Lab 2019 Apr;65(4)

Background: Ovarian cancer is one of the most common cancers among women. With cancer, early detection is paramount to saving lives. However, early detection of ovarian cancer has been fraught with difficulty. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.181030DOI Listing
April 2019
3 Reads
1.084 Impact Factor

Mean Platelet Volume and Platelet Distribution Width Indicate that Platelets Remain Small for Most of Their Lifespans in Patients with Essential Thrombocythemia.

Clin Lab 2019 Apr;65(4)

Background: Platelets are large when young and immature and shrink as they age. The mean platelet volume (MPV) and platelet distribution width (PDW) reflect the volume and distribution of platelets, respectively. We compared the MPVs and PDWs of patients with immune thrombocytopenic purpura (ITP) or essential thrombocythemia (ET) to those of healthy individuals to test whether these values can reflect the pathomechanisms of these diseases. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180938DOI Listing
April 2019
1 Read

PgaB is a Putative Marker for Early Predicting the Virulence of Acinetobacter baumannii Clinical Isolates.

Clin Lab 2019 Apr;65(4)

Background: Acinetobacter baumannii (Ab) is an important opportunistic pathogen in a hospital setting. The virulence varies among different clinical isolates, which can be measured by cytotoxicity assay or Galleria mellonella killing assay. However, these measurements are not suitable for routine clinical laboratory application. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180916DOI Listing
April 2019
1.084 Impact Factor

Prognostic Impact of WT-1 and Survivin Gene Expression in Acute Myeloid Leukemia Patients.

Clin Lab 2019 Apr;65(4)

Background: Wilms Tumor 1 (WT1) and Survivin genes are important leukemia-associated antigens (LAAs) in AML with potential prognostic impact.

Methods: We investigated WT1 and Survivin expression levels by RT-PCR in 61 AML patients in correlation with clinical characteristics and outcomes.

Results: WT1 was overexpressed in 45 patients (73. Read More

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http://www.clin-lab-publications.com/article/2973
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http://dx.doi.org/10.7754/Clin.Lab.2018.180329DOI Listing
April 2019
5 Reads

Peripheral Blood Platelet to Lymphocyte Ratio as Potential Diagnostic and Prognostic Markers of Acute Cerebral Infarction and its Clinical Significance.

Clin Lab 2019 Apr;65(4)

Background: The aim of the present study is to explore the diagnostic and prognostic value of peripheral blood platelet-to-lymphocyte ratio (PLR) in acute cerebral infarction (ACI).

Methods: We enrolled 121 patients with ACI and 35 healthy volunteers in the present study. The lymphocyte and platelet counts and the platelet-to-lymphocyte ratios of the candidates were calculated, and a receiver-operating characteristic (ROC) curve was drawn to examine whether PLR was a sensitive biomarker for distinguishing ACI patients from the healthy volunteers; moreover, the Glasgow outcome scale (GOS) results of the patients were recorded to evaluate the short-term prognosis of the patients, and the relationship between PLR and GOS were investigated. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180912DOI Listing
April 2019
1 Read

The Relationship Between Urothelial Type Bladder Cancer, Plasma 25-Hydroxyvitamin D Levels, and Vitamin D Receptor ApaI BsmI FokI, and TaqI Polymorphisms.

Clin Lab 2019 Apr;65(4)

Background: Bladder cancer is an important health problem which ranks 4th among most frequently seen cancer types in men. In our study we aimed to investigate the correlations among urothelial type bladder cancer polymorphisms, ApaI, BsmI, FokI, and TaqI, prevalently observed in the vitamin D receptor (VDR) gene and plasma vitamin D levels in a Turkish population.

Methods: Our study included 101 patients and 109 control subjects. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180339DOI Listing
April 2019
1 Read

Characterization of Erythromycin and Tetracycline Resistance Genes of Streptococcus gallolyticus Subspecies pasteurianus Strains Isolated from Patients with Septicemia and Bacteremia in Thailand.

Clin Lab 2019 Apr;65(4)

Background: Streptococcus gallolyticus subspecies (subsp.) pasteurianus, previously known as Streptococcus bovis biotype II/2, has been described as a causative agent of endocarditis, neonatal sepsis, meningitis, bacteremia, and colorectal carcinoma in humans. The aim of this study was to characterize the erythromycin and tetracycline resistance genes of S. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180902DOI Listing
April 2019
4 Reads

Decreased Serum Kruppel-Like Factor 7 Level is Positively Associated with Low-Density Lipoprotein Cholesterol Level in Women with Polycystic Ovary Syndrome.

Clin Lab 2019 Apr;65(4)

Background: Kruppel-like factor 7 (KLF7) is associated with type 2 diabetes and obesity; however, at present the KLF7 level in polycystic ovary syndrome (PCOS) remains unreported.

Methods: In this study, serum KLF7, glucose, insulin, C-reactive protein (CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone concentrations were measured in 65 women with PCOS and 61 healthy controls.

Results: Body mass index (BMI) in PCOS and the control group were all < 25 kg/m2. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180908DOI Listing
April 2019
2 Reads

Serum miR-22 Could be a Potential Biomarker for the Prognosis of Breast Cancer.

Clin Lab 2019 Apr;65(4)

Background: This study aims to evaluate whether miR-22 could be used as a potential biomarker to screen breast cancer patients from healthy controls. This has never been explored.

Methods: Real time PCR analysis was carried out to explore the expression of serum miR-22 in breast cancer patients. Read More

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http://www.clin-lab-publications.com/article/2968
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http://dx.doi.org/10.7754/Clin.Lab.2018.180825DOI Listing
April 2019
2 Reads

Diagnostic Value of Circulating miR-324 for Prostate Cancer.

Clin Lab 2019 Apr;65(4)

Background: To investigate the diagnostic value of serum miR-324 in patients with prostate cancer (PC).

Methods: Blood samples from 50 patients with prostate cancer, 30 patients with benign prostatic hyperplasia (BPH), and 20 healthy controls were collected and quantified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The relationship between serum miR-324 level and Gleason classification and TNM staging of prostate cancer was analyzed. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180932DOI Listing

Performance Evaluation of an Enzyme-Linked Immunosorbent Assay for Seven Autoantibodies in Lung Cancer.

Clin Lab 2019 Apr;65(4)

Background: To verify and evaluate the performance characteristics of an enzyme-linked immunosorbent assay (ELISA) assay kit (Hangzhou Cancer probe Biotech Company) for seven autoantibodies (7-AABS), including p53, GAGE7, PGP9.5, CAGE, MAGEA1, SOX2, and GBU4-5.

Methods: Evaluation was carried out according to "Guidelines for performance evaluation of in vitro diagnostic reagent". Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180930DOI Listing
April 2019
1.084 Impact Factor

The rs1986112 Variant is Associated with Increased RAB8B Gene Expression in Schizophrenic Patients.

Clin Lab 2019 Apr;65(4)

Background: Schizophrenia (SCZ) is a serious mental disorder that interferes with a person's cognitive processes and leads to social disability. A wide range of factors may play important roles in increased risk of SCZ development. Genetic contributors are among the most influential actors involved in different molecular mechanisms leading to the development of the nervous system, thus they play pivotal roles in psychotic disorders and SCZ de-velopment. Read More

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http://www.clin-lab-publications.com/article/2964
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http://dx.doi.org/10.7754/Clin.Lab.2018.180832DOI Listing
April 2019
2 Reads

Harmonization of Cardiac Troponin I: Significance of Sample Types.

Clin Lab 2019 Apr;65(4)

Background: Cardiac troponin I (TnI) is one of the most crucial biomarkers for the management of acute coronary syndrome. However, the TnI values can vary when using commercial TnI assays from different vendors. We assessed the feasibility of TnI harmonization using plasma and serum samples. Read More

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http://www.clin-lab-publications.com/article/2963
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http://dx.doi.org/10.7754/Clin.Lab.2018.180813DOI Listing
April 2019
2 Reads

Comparison of Three Immunoassays Systems for Determining Serum Estradiol.

Clin Lab 2019 Apr;65(4)

Background: Estrogens are responsible for the development of the secondary female gender characteristics. Serum estradiol concentration measurements depend widely on automated immunoassay systems such as the Architect i2000SR, Cobas e601, and UniCel DxI 800. Here, we compare the performance of three automated immunoassay systems and investigate the correlation of serum estradiol levels. Read More

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http://www.clin-lab-publications.com/article/2962
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http://dx.doi.org/10.7754/Clin.Lab.2018.180903DOI Listing
April 2019
5 Reads

Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Hypothetical Protein Gene in Escherichia Coli Clinical Isolates.

Clin Lab 2019 Apr;65(4)

Background: Escherichia coli is the most common pathogenic bacteria that frequently causes life-threatening opportunistic human infections, diarrhea, and septicemia in immunocompromised hosts.

Methods: This study aimed to establish a loop-mediated isothermal amplification (LAMP) method for the rapid and sensitive detection of a hypothetical protein from an E. coli-specific gene (GenBank ID: 13702648). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180826DOI Listing

The Consistency Research of Two Incubation Methods in Anti-EBNA1-IgA Antibody Detection.

Clin Lab 2019 Apr;65(4)

Background: The aim of this study was to prove the difference between 37°C water incubation method and the BEP III automated immunoassay analyzer incubation method in anti-EBNA1-IgA antibody detection and to find the best way to improve the consistency of the two incubation methods.

Methods: The 37°C water incubation method and BEP III analyzer incubation method were used with the same panel of samples (n = 39) in anti-EBNA1-IgA antibody detection. Except for incubation, the rest of the steps were performed by the BEP III analyzer in both groups. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180906DOI Listing

Prevalence of Anemia and Iron Deficiency Among Pregnant Women Attending Antenatal Care Service at University of Gondar Hospital, Northwest Ethiopia.

Clin Lab 2019 Apr;65(4)

Background: Anemia, particularly pregnancy related iron deficiency anemia, increases the risk of maternal morbidity and mortality and the effects are more devastating in less developed and developing continents where pregnant women have low socioeconomic status. Thus, this study aimed to assess the prevalence and associated factors of anemia and iron deficiency anemia among pregnant women.

Methods: This institution based, cross-sectional study was conducted from January 1 to April 30, 2015 on a total of 217 pregnant women attending at University of Gondar Hospital, Northwest Ethiopia. Read More

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http://www.clin-lab-publications.com/article/2958
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http://dx.doi.org/10.7754/Clin.Lab.2018.180822DOI Listing
April 2019
5 Reads

Rapid Simultaneous Molecular Stool-Based Detection of Toxigenic Clostridioides difficile by Quantitative TaqMan Real-Time PCR Assay.

Clin Lab 2019 Apr;65(4)

Background: Clostridioides difficile is a major cause of nosocomial infectious diarrhea in hospitalized patients throughout the world.

Methods: A multiplex real-time PCR assay was developed and evaluated in comparison with toxigenic culture (TC) (as gold standard method) for direct detection of toxigenic C. difficile in fecal specimens. Read More

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http://www.clin-lab-publications.com/article/2957
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http://dx.doi.org/10.7754/Clin.Lab.2018.180735DOI Listing
April 2019
2 Reads

As a Novel Procalcitonin Assay is Architect B∙R∙A∙H∙M∙S PCT; Comparison of Two Commercial Systems.

Clin Lab 2019 Apr;65(4)

Background: Procalcitonin (PCT) is the precursor structure of the calcitonin hormone with 116 amino acids. The measurement of serum procalcitonin is currently being safely used in community-acquired pneumonia, bacterial peritonitis and sepsis in the diagnosis, decision on the initiation of treatment, and follow-up of the response to treatment. In this study, it is aimed to compare PCT results obtained by the VIDAS PCT that makes measurements by the enzyme-dependent fluorescence (ELFA) method and Architect PCT method, a chemiluminescent microparticle immunoassay (CMIA) that has just been put into use, both of which are B∙R∙A∙H∙M∙S licensed and have method differences. Read More

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http://www.clin-lab-publications.com/article/2932
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http://dx.doi.org/10.7754/Clin.Lab.2018.180727DOI Listing
April 2019
11 Reads

Molecular Mechanism Exploration of Pancreatitis Based on miRNA Expression Profile.

Clin Lab 2019 Mar;65(3)

Background: Pancreatitis is a popular disease around the world, and can also lead to pancreatic cancer. Pancreatitis can be distinguished into two types, acute pancreatitis (AP) and chronic pancreatitis (CP). Every year, AP leads to approximately 275,000 new cases and is the most frequent gastrointestinal disease in American. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180807DOI Listing
March 2019
1 Read

Comparison of Indirect Immunofluorescence and Passive Particle Agglutination for the Detection of Mycoplasma Pneumoniae Antibodies.

Clin Lab 2019 Mar;65(3)

Background: Mycoplasma pneumoniae (MP) is the most predominant pathogen causing pneumonia. The present study compares two serological assays, the indirect immunofluorescence assay (IFA) and the passive particle agglutination assay (PPA), in order to assist clinicians in selecting accurate diagnosis methods.

Methods: Sera from 127 patients suffering from mycoplasma pneumonia and 76 from the healthy group were analyzed simultaneously by PPA and IFA. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180901DOI Listing

MiR-98-5p may be a Biomarker for Screening Bronchial Asthma in Children by Targeting IL-13.

Clin Lab 2019 Mar;65(3)

Background: In the present study, we mainly focused on miR-98-5p, which is shown to be dysregulated in various diseases. However, whether miR-98-5p is increased in the serum of asthma patients has never been explored.

Methods: The levels of miR-98-5p and IL-13 were determined in the serum of bronchial asthma children. Read More

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http://www.clin-lab-publications.com/article/2953
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http://dx.doi.org/10.7754/Clin.Lab.2018.180834DOI Listing
March 2019
7 Reads

Long Non-Coding RNA 001089 is a Prognostic Marker and Inhibits Glioma Cells Proliferation and Invasion.

Clin Lab 2019 Mar;65(3)

Background: Long noncoding RNAs (lncRNAs) are a novel type of endogenous noncoding RNA that are involved in the regulation of gene expression and play important roles in several types of cancer. LncRNA001089 is an intergenic lncRNA associated with cancer progression and tumor occurrence; however, the role and function of LncRNA001089 in glioma remains unclear.

Methods: In this study, we determined the expression levels of LncRNA001089 in tissues of glioma patients and explored its effect on glioma cell metastasis and proliferation using U251 glioma cell lines. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180817DOI Listing
March 2019
1.084 Impact Factor

Diagnostic Potential for Circular RNAs in Gastric Carcinoma: a Meta-Analysis.

Clin Lab 2019 Mar;65(3)

Background: Circular RNAs (circRNAs) are potential, novel biomarkers for the early diagnosis of gastric carcinoma. Herein, a meta-analysis was conducted to assess the diagnostic potential for circRNAs in gastric carcinoma.

Methods: Online databases were searched for eligible studies. Read More

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http://www.clin-lab-publications.com/article/2951
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http://dx.doi.org/10.7754/Clin.Lab.2018.180810DOI Listing
March 2019
5 Reads

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Lower Extremity Vascular Lesions in Chinese Patients with Type 2 Diabetes.

Clin Lab 2019 Mar;65(3)

Background: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are inflammatory markers used for prediction of chronic complications of diabetes. Lower extremity arterial disease (LEAD) is one of chronic complications of type 2 diabetes mellitus (T2DM). The correlation between NLR, PLR, and lower extremity vascular lesions was investigated in subjects with T2DM to determine the best predictive marker for LEAD. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180804DOI Listing
March 2019
4 Reads

Combined use of Serum miR-338-3p, Cartilage Oligomeric Matrix Protein and Chondroitin Sulfate-846 in the Early Diagnosis of Knee Osteoarthritis.

Clin Lab 2019 Mar;65(3)

Background: In this study, the serum levels of miR-338-3p, COMP, and CS-846 were detected in the patients with KOA and healthy controls, to explore the value of miR-338-3p, COMP, and CS-846 in the early diagnosis of KOA.

Methods: Real-time PCR was carried out to evaluate the level of miR-338-3p in KOA patients and healthy controls. Spearman's correlation coefficient was performed to examine the correlation between the expression of miR-338-3p, COMP, and CS-846. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180803DOI Listing
March 2019
1 Read

Assessment of Red Blood Cell Distribution Width and Multiple Myeloma in a Guangxi Population: a Retrospective Study.

Clin Lab 2019 Mar;65(3)

Background: Red blood cell distribution width (RDW) has been reported as a marker for inflammation and tumors. The present study aims to investigate the use of RDW in patients with multiple myeloma (MM).

Methods: Seventy-three patients with newly diagnosed symptomatic multiple myeloma (SMM), 39 patients with relapsed multiple myeloma (RMM), and 91 healthy individuals were recruited into this study. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180738DOI Listing
March 2019
1 Read

Investigation of Virulence Genes and Resistance Genes in a Group of Staphylococcus aureus Isolated in Yuhang, China.

Clin Lab 2019 Mar;65(3)

Background: To investigate the distribution of virulence genes and resistance genes in a group of Staphylococcus aureus (S. aureus).

Methods: From February 2013 to April 2014, a total of 39 strains of S. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180737DOI Listing

Fulminant Escherichia coli Bacteremia Detected via Peripheral Blood Smear.

Authors:
Jong Ho Lee

Clin Lab 2019 Mar;65(3)

Background: Detection of bacteremia via a peripheral blood smear is not a routine diagnostic test and is not widely used.

Methods: A 66-year-old male patient was admitted to the emergency room owing to a head injury. Basic examinations and peripheral blood smear were performed. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180821DOI Listing
March 2019
1 Read

Clinical Performance of SurePath™ Preservative Compared to PreservCyt® with Cobas® and Hybrid Capture® 2 HPV Tests in a Colposcopy Population.

Clin Lab 2019 Mar;65(3)

Background: Until recently, no HPV test had been US FDA-approved for SurePath preservative. Clinical performance remains incompletely understood. The clinical performances of the Cobas HPV Test (Cobas) and Hybrid Capture 2 High-Risk HPV DNA Test (HC2) with PreservCyt and SurePath preservatives were compared. Read More

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http://www.clin-lab-publications.com/article/2945
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http://dx.doi.org/10.7754/Clin.Lab.2018.180734DOI Listing
March 2019
2 Reads

Normal Reference Intervals of Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, Lymphocyte-To-Monocyte Ratio, and Systemic Immune Inflammation Index in Healthy Adults: a Large Multi-Center Study from Western China.

Clin Lab 2019 Mar;65(3)

Background: Numerous studies have shown that the hematological components of the systemic inflammatory response, including the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and the systemic immune inflammation index (SII) are efficient prognostic indicators in patients with cancers. Most of the studies did not investigate the reference intervals (RIs) of these parameters in healthy controls.

Methods: A retrospective cohort study was performed on healthy ethnic Han population aged between 18 and 79 years of age by retrieving the data from a healthy routine examination center database and laboratory infor-mation system of four participating centers in western China. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180715DOI Listing
March 2019
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1.084 Impact Factor

Serum Hepcidin Levels Predict Intestinal Iron Absorption in Patients with Inflammatory Bowel Disease.

Clin Lab 2019 Mar;65(3)

Background: Hepcidin has been shown to be inversely associated with iron absorption and the expression of iron transport proteins in healthy females and patients with iron deficiency. Data describing the relationship between hepcidin expression and iron absorption in patients with inflammatory bowel disease (IBD) are lacking. The objective of this study was to assess the relationship between serum concentrations of hepcidin and iron absorption in patients with IBD and iron deficiency by means of an oral iron absorption test. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190106DOI Listing
March 2019
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Elevated Red Blood Cell Distribution Width Combined White Blood Cell in Peripheral Blood Routine Have a Better Sensitivity than CURB-65 Scores in Predicting ICU Admission and Mortality in Adult Community-Acquired Pneumonia Patients.

Clin Lab 2019 Mar;65(3)

Background: Scoring systems including CURB-65 and Pneumonia Severity Index (PSI) and novel or traditional biomarkers including procalcitonin (PCT) and c-reactive protein (CRP) are very significant for understanding the severity and prognosis in community-acquired pneumonia (CAP) patients, while prognostic items are useful for CAP prognostication and point-of-care decisions. The aim of this study was to investigate the usefulness of peripheral blood routine items in predicting ICU admission and 30-day mortality in CAP patients.

Methods: A retrospective study was conducted. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180828DOI Listing
March 2019
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Persistent Anemia Combined Increased Serum Sedimentation (ESR) for More Than Two Years Firstly Misdiagnosed as Lymphoma Ultimately Confirmed Systemic Lymph Nodes Tuberculosis by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Pathology: a Case Report and Literature Review.

Clin Lab 2019 Mar;65(3)

Background: Anemia combined with increased serum sedimentation (ESR) can be secondary to many diseases and may be ignored when the patient had few clinical symptoms. We report a case of persistent anemia combined with ESR for more than 2 years firstly misdiagnosed as lymphoma. When she received a chest CT scan multiple enlarged lymph nodes were found. Read More

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http://www.clin-lab-publications.com/article/2941
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http://dx.doi.org/10.7754/Clin.Lab.2018.180836DOI Listing
March 2019
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Correlation Analysis of miR-122-5p and Occludin with Sperm Density in Oligospermia Patients' Sperm.

Clin Lab 2019 Mar;65(3)

Background: To analyze the correlation of miR-122-5p and occludin with sperm density in oligospermia patients' sperm.

Methods: The expression of miR-122-5p and its target protein occludin in the sperm and exfoliated cells of semen were studied using real-time reverse transcription-polymerase chain reaction and Western blot analysis.

Results: The expression level of miR-122-5p in the sperm and exfoliated cells of patients with oligospermia semen was 0. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180814DOI Listing

CD81 Expression in the Differential Diagnosis of Chronic Lymphocytic Leukemia.

Clin Lab 2019 Mar;65(3)

Background: Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 ex-pression in the differential diagnosis of CLL and MCL. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180802DOI Listing
March 2019
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Overexpression of LncRNA-UCA1 Correlates with Lung Adenocarcinoma Progression and Poor Prognosis.

Clin Lab 2019 Mar;65(3)

Background: Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been predicted to play a critical role in various biological processes including tumorigenesis. However, the clinical significance of UCA1 in lung adenocarcinoma (LUAD) is still not understood in detail. The aim of this study was to assess the clinical significance of the UCA1 expression levels in LUAD based on publicly available data and to evaluate its potential signaling pathways. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180739DOI Listing
March 2019
1.084 Impact Factor

Analytical Evaluation of Vitamin D Measurements in Routine Laboratories.

Clin Lab 2019 Mar;65(3)

Background: Its increasing clinical importance has turned 25-hydroxy-Vitamin D (25(OH)D) into an indispensable test in clinical laboratories. In this study, we aimed to analyze the analytical performances of two widely used immunoassays, namely new restandardized Abbott product Architect 25-OH Vitamin D test and the Beckman Coulter product Access 25(OH) Vitamin D Total Test by making comparisons with the reference method liquid chromatography tandem mass spectrometry (LC-MS/MS).

Methods: The new restandardized Architect I2000SR System (Abbott Laboratories, IL, USA; ref 5P02) and Access2 (Beckman Coulter, Brea, CA, USA; ref B24838) immunoassay were compared with LC-MS/MS (Shimadzu LCMS-8030, Kyoto, Japan) method 25(OH)D test for precision and reproducibility in 90 serum samples. Read More

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http://www.clin-lab-publications.com/article/2936
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http://dx.doi.org/10.7754/Clin.Lab.2018.180731DOI Listing
March 2019
9 Reads