4,411,431 results match your criteria Clinical infectious diseases : an official publication of the Infectious Diseases Society of America[Journal]


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
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Effects of Homeopathic Phosphorus on Encephalitozoon cuniculi-Infected Macrophages In-Vitro.

Homeopathy 2019 Apr 18. Epub 2019 Apr 18.

Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil.

Introduction:   (), a fungus that acts as an intracellular pathogen, causes a marked neurological syndrome in many host species and is a zoonotic concern. Although no well-established treatment for this syndrome is known, previous successful clinical experience using homeopathic phosphorus has been described in which symptom remission with no mortality occurred in 40/42 animals by means of unknown immunological mechanisms. The latter observation was the main motivation for this study. Read More

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http://dx.doi.org/10.1055/s-0039-1678700DOI Listing

Optimization of Whole-Body CT Examinations of Polytrauma Patients in Comparison with the Current Diagnostic Reference Levels.

Rofo 2019 Apr 18. Epub 2019 Apr 18.

Department of Diagnostic and Interventional Radiology, University-Hospital Giessen, Justus-Liebig-University Giessen, Germany.

Purpose:  Evaluation of the dose values of a polytrauma whole-body CT examination used in clinical practice with regard to the 2016 updated diagnostic reference levels and reduction of the mean exposure levels using simple optimization steps.

Materials And Methods:  In each case, 100 exposure values before and after dose optimization were compared with the old and new diagnostic reference levels. The grayscale values and the signal-to-noise ratio (SNR) were determined for the lung, the aortic arch and the liver. Read More

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http://dx.doi.org/10.1055/a-0881-3113DOI Listing

Contribution of Palmar Radiocarpal and Ulnocarpal Ligaments to the Stability of the Canine Antebrachiocarpal Joint.

Vet Comp Orthop Traumatol 2019 Apr 18. Epub 2019 Apr 18.

The Laboratory of Biomechanics, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Objective:  The aim of this study was to evaluate the contribution of the palmar radiocarpal ligament and the palmar ulnocarpal ligament to canine antebrachiocarpal joint stability.

Materials And Methods:  The right carpus of four dog cadavers, free of musculoskeletal pathology, was stripped of muscle. Each specimen was placed into a custom-made joint testing machine and tested at 15° extension, and 0° and 15° flexion. Read More

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http://dx.doi.org/10.1055/s-0039-1685208DOI Listing

[Pupil disorders].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

The evaluation of pupillary function is a keystone in the neuro-ophthalmic assessment of patients. The diagnosis of an afferent or efferent pupillary disorder is crucial in the acquisition of a broad range of diseases of the brain or the peripheral nervous system. This "update" of pupillary disorders covers a major part of clinical conditions eye doctors have to expect in their daily practice. Read More

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http://dx.doi.org/10.1055/a-0885-2467DOI Listing

[Botulinumtoxin in Ophthalmology].

Authors:
Bettina Wabbels

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Botulinum toxin has been first applied in ophthalmology (as treatment for strabismus) and is nowadays widely used in many clinical areas. Currently the main application in ophthalmology is the treatment of essential blepharospasm and hemifacial spasm. Other important indications for botulinum toxin in ophthalmology are eyelid retraction in Graves' disease and the induction of protective ptosis in lagophthalmos or corneal diseases. Read More

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http://dx.doi.org/10.1055/a-0885-2107DOI Listing

[Feed refusal in fattening bulls because of maize silage contamination by Jimson weed (Datura stramonium)].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):125-130. Epub 2019 Apr 18.

Institut für Tierernährung, Stiftung Tierärztliche Hochschule Hannover.

A sudden decrease in feed intake (within 24 hours) without an impaired general condition occurred on a bull-rearing and -fattening farm in western Germany in December 2017. One day later, some of the bulls displayed signs of ruminal tympany (free gas bloat) and the reduction in feed intake became more severe. The maize silage was recognized as the cause of the observed symptoms, because clinical signs first appeared after taking the silage from a different localization within the bunker silo. Read More

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http://dx.doi.org/10.1055/a-0862-5781DOI Listing

Feasibility of transabdominal Doppler ultrasonography for studying ovarian blood flow characteristics in cycling gilts.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):77-85. Epub 2019 Apr 18.

Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University of Leipzig.

Objective: The aim of this study was to assess ovarian blood flow characteristics by applying transabdominal color Doppler ultrasonography during the course of the estrous cycle in gilts.

Materials And Methods: Estrus and ovulation were synchronized in 15 pubertal gilts. During their consecutive spontaneous estrous cycle the gilts were sonographically scanned daily and ovarian blood flow was determined by imaging perfused areas of the ovarian hilus and the ovarian tissue. Read More

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http://dx.doi.org/10.1055/a-0858-0076DOI Listing

Normal Visual Recovery after Optic Neuritis Despite Significant Loss of Retinal Ganglion Cells in Patients with Multiple Sclerosis.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):425-428. Epub 2019 Apr 18.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland.

Background: Optic neuritis (ON) is a frequent manifestation of demyelinating attack in multiple sclerosis (MS). Initial visual loss can vary from minimal to complete. Visual improvement occurs in about 95% of patients, some of them recovering to normal [visual acuity (VA), color vision, visual field (VF)]. Read More

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http://dx.doi.org/10.1055/a-0853-1721DOI Listing

[Clinical Features, Imaging and Treatment of a Symptomatic Vasoproliferative Tumour of the Retina (VPTR)].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):571-574. Epub 2019 Apr 18.

Augenklinik, Universitätsmedizin der Johannes-Gutenberg Universität, Mainz.

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http://dx.doi.org/10.1055/a-0857-6455DOI Listing

[Acute Juvenile Ophthalmoplegia (Miller Fisher Syndrome): an Interesting Case].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):469-471. Epub 2019 Apr 18.

Ophthalmica, Institute of Ophthalmology and Ocular Microsurgery, Thessaloniki, Griechenland.

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http://dx.doi.org/10.1055/a-0832-1815DOI Listing

Corneal Endothelial Decompensation after Ocular Chemical Burn: Description of a New Finding.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):371-376. Epub 2019 Apr 18.

Augenklinik, Universitatsspital Basel, Basel, Switzerland.

Background: Ocular chemical burn is an ophthalmological emergency. Therefore, chemical injuries should be promptly addressed in order to initiate the appropriate treatment as soon as possible and optimize the visual prognosis. We present a retrospective study of ten cases with ocular chemical burn including one with superglue and one with a liquid plaster material injury and describe their clinical course. Read More

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http://dx.doi.org/10.1055/a-0857-6538DOI Listing

Repeat Surgery for Patients Operated in Childhood for Early-Onset Esotropia and Suffering from Persistent Residual, Recurrent or Consecutive Strabismus.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):446-450. Epub 2019 Apr 18.

Pediatric Ophthalmology, Vision Rive Droite, Le Grand Saconnex, Switzerland.

Background: Patients operated in childhood for early esotropia may suffer from persistent strabismus, whether residual, recurrent, or consecutive, usually with a more complex oculomotor imbalance than in primitive strabismus.

History And Signs: The clinical data are fundamental, in particular, (1) the basic accommodation-free deviation, (2) the horizontal far/near incomitance, (3) the cyclovertical incomitances and/or A or V pattern, and (4) the motility restrictions. In complicated cases, magnetic resonance tomography of the orbits showed the anomalies of the eye and muscle position. Read More

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http://dx.doi.org/10.1055/a-0859-6974DOI Listing

A Simple, Inexpensive, and Precise Photographic Method for Intraoperative Toric IOL Alignment.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):391-397. Epub 2019 Apr 18.

Dept. of Ophthalmology, Pallas Kliniken AG, Olten, Switzerland.

Background: It was the aim of this study to analyse the refractive outcome of toric intraocular lens (t-IOL) implantation guided by a newly developed method of photographic alignment.

Material And Methods: Fourteen eyes of 10 patients (6 females, 4 males, age 63.4 ± 6. Read More

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http://dx.doi.org/10.1055/a-0861-9601DOI Listing

The Use of Junfeng BFS Water (JBW) in Dry Eye Syndrome.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):366-370. Epub 2019 Apr 18.

Augenklinik, Otto von Guericke Universität Magdeburg, Magdeburg, Germany.

Background And Purpose: Junfeng BFS Water (JBW) is normal drinking water treated by an extremely low frequency electromagnetic field with certain electromagnetic oscillations. This leads to a change in physical water properties, such as an increase in permittivity and an increase in dissolved oxygen. Animal studies show that JBW has certain biological effects, such as improvement in microcirculation, cell hydration, and blood rheology. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0838-4836
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http://dx.doi.org/10.1055/a-0838-4836DOI Listing
April 2019
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Encephalopathy in neonates with subgaleal hemorrhage is a key predictor of outcome.

Pediatr Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Objective: Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clinical encephalopathy to short-term outcomes in neonates with SGH. Read More

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http://dx.doi.org/10.1038/s41390-019-0400-1DOI Listing

Validation and Reliability of the Italian Version of the Speech Handicap Index.

Folia Phoniatr Logop 2019 Apr 18:1-9. Epub 2019 Apr 18.

Otorhinolaryngology Division, Department of Surgical Sciences, University of Turin, Turin, Italy.

Background: Speech problems negatively affect the quality of life of patients with oral and oropharyngeal cancer. An appropriate self-rating questionnaire named Speech Handicap Index (SHI) was developed for these individuals. The aim of this study was the cross-cultural adaptation and the validation of the Italian version of the SHI. Read More

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http://dx.doi.org/10.1159/000496179DOI Listing

The Degree of Multidimensional Severity of Alcohol Use Disorder among Treatment-Seeking Patients: Is There an Additive Effect of Parental Alcohol Use Disorder?

Eur Addict Res 2019 Apr 18:1-7. Epub 2019 Apr 18.

Unit for Clinical Alcohol Research, Unit for Psychiatric Research, Department of Clinical Research, University of Southern, Odense, Denmark.

Background: The additive effect of parental alcohol use disorders (AUD) is conventionally defined as an increasing risk of the offspring developing AUD relative to family history negative, < family history positive with 1 parent (FHP1), < FHP2. The few studies on the additive effect of parental AUD have focused on the risk of development of offspring AUD and not on the degree of multidimensional AUD addiction severity.

Aims: The aims of the present study were to examine the frequency of treatment-seeking outpatients exposed to FHP1 and FHP2 and whether addiction severity was impacted by the additive effect of parental AUD among AUD female and male offspring. Read More

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http://dx.doi.org/10.1159/000499935DOI Listing
April 2019
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The Mealtime Assessment Scale (MAS): Part 1 - Development of a Scale for Meal Assessment.

Folia Phoniatr Logop 2019 Apr 18:1-13. Epub 2019 Apr 18.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: Safety and efficacy of swallowing in instrumental assessment may not overlap safety and efficacy of swallowing during meal, as personal and environmental factors can influence the performance. This study aims to develop a scale to assess the safety and efficacy of swallowing during meal.

Methods: A working group discussed the latent construct, target population, and purposes of the scale. Read More

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http://dx.doi.org/10.1159/000494135DOI Listing

Towards an Integrated Curriculum in a Speech and Language Pathology Education Programme: Development and Constituents' Initial Responses.

Folia Phoniatr Logop 2019 Apr 18:1-12. Epub 2019 Apr 18.

Division of Speech and Language Pathology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Background: A traditional curricular structure may challenge integration between foundational and clinical sciences in speech and language pathology (SLP) education. This project aimed to increase curriculum integration at a Swedish SLP education programme.

Methods: Learning outcomes in the existent curriculum were copied from their original courses and re-structured with reference to vertical tracks, in order to address them within and across years of study. Read More

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http://dx.doi.org/10.1159/000497609DOI Listing

Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

Effects of the Narrative Intervention Program for Preschool Portuguese Children.

Folia Phoniatr Logop 2019 Apr 18:1-7. Epub 2019 Apr 18.

CINTESIS.UA - Center for Health Technology and Services Research (UID/IC/04255/2013) and School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal,

Objective: This article analyzes the contribution of a narrative intervention program in linguistic performance (measured by the percentage of correct consonants [PCC], mean length of utterance [MLU], and auditory memory [AM]) of children.

Patients And Methods: A group of 14 children with primary language impairments participated in this study. The children were divided into two groups (seven children in each): the narrative intervention group (experimental group) and the control group. Read More

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http://dx.doi.org/10.1159/000496793DOI Listing

Sex Influence on the Efficacy and Safety of Sacubitril/Valsartan.

Cardiology 2019 Apr 18;142(2):73-78. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Madrid, Spain,

Background: Women are underrepresented in sacubitril/valsartan (SV) clinical trials. The aim of this study was to assess sex-specific differences in efficacy, tolerability, and safety of SV in real-world heart failure with reduced ejection fraction (HFrEF) patients.

Methods: A prospective registry in 10 centers including all patients who started SV during the last 6 months was analyzed in this study. Read More

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http://dx.doi.org/10.1159/000498984DOI Listing

Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy.

Neuroendocrinology 2019 Apr 19. Epub 2019 Apr 19.


Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protective agents, as well as personalized PRRT treatment regiments. Read More

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http://dx.doi.org/10.1159/000500473DOI Listing

Routine Is the Worst Enemy of the Dialysis Patient.

Blood Purif 2019 Apr 18:1-2. Epub 2019 Apr 18.

Clinical Research Branch, Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Italy.

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http://dx.doi.org/10.1159/000498980DOI Listing

Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

Y Park, Internal medicine, Seoul National University College of Medicine, Seoul, Korea (the Republic of).

Synergistic effects of BRAFV600E and TERT promoter mutations on the poor clinical outcomes in papillary thyroid cancer (PTC) have been demonstrated. The potential mechanism of this phenomenon has been proposed: MAPK pathway activation by the BRAFV600E mutation may upregulate E-twenty six (ETS) transcription factors, increasing TERT expression by binding to the ETS-binding site generated by the TERT promoter mutation; however, it has not yet been fully proven. This article provides transcriptomic insights into the interaction between BRAFV600E and TERT promoter mutations mediated by ETS factors in PTC. Read More

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http://dx.doi.org/10.1530/ERC-17-0562DOI Listing

High soluble CGA levels are associated with poor survival in bladder cancer.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1530/EC-19-0068DOI Listing

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
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Machine learning and big data in psychiatry: toward clinical applications.

Curr Opin Neurobiol 2019 Apr 15;55:152-159. Epub 2019 Apr 15.

Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, England, United Kingdom; Division of Psychiatry, University College London, London, England, United Kingdom; Camden and Islington NHS Foundation Trust, London, England, United Kingdom. Electronic address:

Psychiatry is a medical field concerned with the treatment of mental illness. Psychiatric disorders broadly relate to higher functions of the brain, and as such are richly intertwined with social, cultural, and experiential factors. This makes them exquisitely complex phenomena that depend on and interact with a large number of variables. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09594388183008
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http://dx.doi.org/10.1016/j.conb.2019.02.006DOI Listing
April 2019
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Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing

Intraoperative ultrasonography (ioUS) characteristics of focal cortical dysplasia (FCD) type II b.

Seizure 2019 Mar 12;69:80-86. Epub 2019 Mar 12.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, USA.

Purpose: Focal cortical dysplasia (FCD) is one of the major causes of drug-resistant epilepsy. Surgery has proved to be the treatment of choice, however up to a third of patients experience only partial resection. Ill-defined borders and lesions embedded in eloquent areas are two of the main drawbacks of FCD surgery. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.020DOI Listing

More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

J Clin Virol 2019 Apr 7;116:11-17. Epub 2019 Apr 7.

Department of Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives: Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study Design: A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.04.003DOI Listing

Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair.

Psychoneuroendocrinology 2019 Mar 29;106:179-182. Epub 2019 Mar 29.

Chair of Biopsychology, Faculty of Psychology, Technische Universität Dresden, Germany.

Epigenetic signatures, such as DNA methylation (DNA), have been implicated in long-term dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and related health risks. Based on a wealth of neuroendocrine studies on genetic polymorphisms in the serotonin transporter gene (SLC6A4), this locus constitutes a key candidate to explore associations of DNA patterns and HPA-axis functioning. The few studies addressing this link so far exclusively relied on spot measurements of HPA-axis activity, which may not adequately reflect cortisol output over prolonged periods of time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530193007
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.033DOI Listing
March 2019
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Interaction of neurotransmitters and neurochemicals with lymphocytes.

J Neuroimmunol 2019 Apr 11;332:99-111. Epub 2019 Apr 11.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.006DOI Listing

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing

Clinical analysis of syringomyelia resulting from spinal hemangioblastoma in a single series of 38 consecutive patients.

Clin Neurol Neurosurg 2019 Apr 1;181:58-63. Epub 2019 Apr 1.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, PR China; Key laboratory of Neurosurgical Diseases, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road, NO 1, Zhengzhou, Henan Province, 450052, PR China. Electronic address:

Objective: Syringomyelia was predominantly caused by Chiari malformation or intramedullary ependymoma. The goal of this study was to identify factors related to clinical outcomes and spinal hemangioblastoma (SH)-induced syringomyelia formation in a single series of patients.

Patient And Methods: Thirty-eight patients with SH were treated with microsurgery from January 2013 to December 2018. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.025DOI Listing

Cost-benefit analysis of the use of tranexamic acid in total replacement hip surgery.

J Clin Anesth 2019 Apr 15;57:124-128. Epub 2019 Apr 15.

Office of Health Economics, London, UK.

Study Objective: To establish the best dose regimen for tranexamic acid (TXA) in total hip replacement surgery.

Design: Secondary analysis based on data from a multicenter double-blind randomized clinical trial.

Setting: Two hospitals in Spain. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.04.006DOI Listing

Protective effects of tribulus terrestris extract and angiotensin blockers on testis steroidogenesis in copper overloaded rats.

Ecotoxicol Environ Saf 2019 Apr 15;178:113-122. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Sharkia Gov., Egypt. Electronic address:

The rational of the current study was to assess whether Tribulus terrestris extract (TTE) could alleviate long-term copper (Cu) overload-induced testicular dysfunction compared to enalapril and losartan. Rats were administered either vehicle (control group, n = 10) or copper sulfate pentahydrate (CuSO·5HO, 200 mg/kg, p.o) for 90 days (n = 40). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.012DOI Listing

Child sexual abuse, disclosure and PTSD: A systematic and critical review.

Child Abuse Negl 2019 Apr 15;92:196-208. Epub 2019 Apr 15.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

Background: Child sexual abuse (CSA) is a prevalent exposure with potentially serious, negative health consequences, including post-traumatic stress disorder (PTSD) and its symptomatology.

Objective: To conduct a systematic and critical review in order to investigate the relationship between CSA disclosure patterns and PTSD.

Participants And Setting: Studies included clinical, college and community-based samples of adults' and children's experiences of CSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452134193013
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http://dx.doi.org/10.1016/j.chiabu.2019.04.006DOI Listing
April 2019
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Trauma-Focused Cognitive Behavioral Therapy for Childhood Traumatic Separation.

Child Abuse Negl 2019 Apr 15;92:179-195. Epub 2019 Apr 15.

Department of Psychiatry, Allegheny General Hospital, Allegheny Health Network, Drexel University College of Medicine, 4 Allegheny Center, 8th Floor, Pittsburgh, PA 15212, USA. Electronic address:

Objectives: In light of the current U.S. family separation crisis, there is growing attention to Childhood Traumatic Separation, defined here as a significant traumatic stress reaction to a familial separation that the child experiences as traumatic. Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.03.006DOI Listing

EEG changes in patients on antipsychotic therapy: A systematic review.

Epilepsy Behav 2019 Apr 15;95:1-9. Epub 2019 Apr 15.

Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: The objective of the study was to characterize the electroencephalogram (EEG) changes associated with different antipsychotic medications based on the evidence from the literature.

Methods: A systematic search of the databases Medline, PsycINFO, and PubMed was conducted. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this systematic review. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.005DOI Listing

Getting the mouse out of the box: Tool innovation in preschoolers.

J Exp Child Psychol 2019 Apr 15;184:65-81. Epub 2019 Apr 15.

Department of Developmental Psychology, Heidelberg University, 69117 Heidelberg, Germany.

Following the literature, children younger than 8 years rarely innovate a tool. Theories on innovation and comparative research on tool manufacturing suggest that children's performance may depend on the task context. The current study explored whether preschool children's poor performance in past research could be attributed to short time limits and the required manufacturing method. Read More

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http://dx.doi.org/10.1016/j.jecp.2019.03.005DOI Listing
April 2019
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Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer.

Biomaterials 2019 Apr 8;208:83-97. Epub 2019 Apr 8.

Department of Pharmaceutical Sciences and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, USA. Electronic address:

Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.04.005DOI Listing

Appendiceal mucocele-A rare case report.

Int J Surg Case Rep 2019 Apr 9;58:21-25. Epub 2019 Apr 9.

Deprtment of General Surgery, JSS Medical College and Hospital, Mysore, India. Electronic address:

Introduction: Appendiceal mucocele is a rare disease and has a clinical picture that resembles acute appendicitis. A correct diagnosis before surgery is very important for the selection of surgical technique(appendicectomy/colectomy)to avoid severe intraoperative and postoperative complications. The work has been reported in line with the SCARE criteria (Agha et al. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.04.008DOI Listing

The biographical gaze: Psychotherapeutic practice in psychosomatic hospitals in Germany.

Authors:
Sabine Flick

Soc Sci Med 2019 Mar 28;230:83-90. Epub 2019 Mar 28.

Goethe-Universität Frankfurt a.M. Institut für Soziologie, Theodor-W.-Adorno-Platz 6, 60323, Frankfurt, Germany. Electronic address:

This article introduces the concept of a "biographical gaze" based on two dimensions: On one hand, I draw on findings from my qualitative empirical research on psychotherapists' practice and their interpretation of patients' suffering. The case study was conducted in psychosomatic hospitals in Germany and focused on psychotherapists based on different kinds of data (supervision transcripts, interviews, medical records, and questionnaires). On the other hand, I connect this research with theories on the clinical gaze, as well as Bourdieu's critique of the "biographical illusion. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.03.037DOI Listing
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