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    12786 results match your criteria Clinical endocrinology[Journal]

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    Twin Models of Environmental and Genetic Influences on Pubertal Development, Salivary Testosterone and Estradiol in Adolescence.
    Clin Endocrinol (Oxf) 2017 Nov 21. Epub 2017 Nov 21.
    Department of Psychology, University of Texas at Austin, Austin, Texas, USA.
    Objective: Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol and pubertal status, into genetic and environmental components.

    Design: A sample of male and female adolescent twins from the greater Austin and Houston areas provided salivary samples, with a subset of participants providing longitudinal data at two waves. Read More

    Central and Peripheral Leptin and Agouti-Related Protein during and after Pregnancy in Relation to Weight Change.
    Clin Endocrinol (Oxf) 2017 Nov 20. Epub 2017 Nov 20.
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden.
    Objective: To study changes of neuropeptides and adipokines in cerebrospinal fluid (CSF) and serum from pregnancy to post-pregnancy in relation to weight changes, fat mass and glucose metabolism.

    Context: With high postpartum weight retention being a risk factor in future pregnancies and of life-long obesity we evaluated neuropeptide and adipokine changes in women who either gained weight or were weight stable.

    Design: Women were followed for 5±1 years after pregnancy and divided into two groups, Weight-Stable and Weight-Gain, by weight change from start of pregnancy. Read More

    Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing Syndrome after remission.
    Clin Endocrinol (Oxf) 2017 Nov 20. Epub 2017 Nov 20.
    Group of Endocrine Disorders, IDIBAPS, Barcelona, Spain.
    Objective: Sustained evidence from observational studies indicates that after remission of Cushing Syndrome (CS) a cardiovascular risk phenotype persists. Here we performed a translational study in active CS and CS in remission to evaluate the subclinical cardiometabolic burden and to explore the direct proinflammatory and prothrombotic potential of their sera on the endothelium in an in vitro translational atherothrombotic cell model.

    Patients: Cross-sectional study. Read More

    Long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer.
    Clin Endocrinol (Oxf) 2017 Nov 20. Epub 2017 Nov 20.
    Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Objective: Thyroid hormone suppression therapy has been widely used in the treatment of thyroid cancer, but concerns have been raised about the cardiovascular risks of this treatment. The objective of this study was to evaluate long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer (DTC) and to assess the effect of TSH suppression and radioiodine (RAI) treatment on the cardiovascular outcome.

    Design: Retrospective cohort study. Read More

    Hormone therapy and patients satisfaction with treatment, in a large cohort of diverse disorders of sex development (DSD).
    Clin Endocrinol (Oxf) 2017 Nov 17. Epub 2017 Nov 17.
    Klinik für Pädiatrische Endokrinologie und Diabetologie Charité - Universitätsmedizin Berlin, corporate member of, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Germany.
    Objectives: To describe and investigate the hormone treatments in individuals with different forms of disorders of sex development (DSD), and the patients own views on their treatment.

    Design: Multicentre cross-sectional clinical evaluation, dsd-LIFE in six European countries from 02/2014 to 09/2015.

    Participants: 1040 adolescents and adults (≥16 years) with different DSD conditions. Read More

    Anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Nov 16. Epub 2017 Nov 16.
    Research Faculty, Weill Cornell Medicine, Doha, Qatar.
    Objective: Anti-Müllerian hormone (AMH) is derived from the small antral follicles and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of AMH in the classical phenotype of PCOS was defined within a Caucasian population.

    Design: This was a cross sectional study. Read More

    Clinical and Genetic Characteristics of Pseudohypoparathyroidism in the Chinese Population.
    Clin Endocrinol (Oxf) 2017 Nov 14. Epub 2017 Nov 14.
    Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences (CAMS), Beijing, 100730, China.
    Background: Pseudohypoparathyroidism (PHP) is caused by mutations and epimutations in the GNAS locus, and characterized by the possibility of resistance to multiple hormones and Albright's hereditary osteodystrophy. PHP can be classified into the forms 1A/C, sporadic 1B, and familial 1B.

    Objectives: To obtain an overall view of the clinical and genetic characteristics of the Chinese PHP patient population. Read More

    TERT promoter hypermethylation is associated with metastatic disease in abdominal paraganglioma.
    Clin Endocrinol (Oxf) 2017 Nov 11. Epub 2017 Nov 11.
    Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital CCK, SE-17176, Stockholm, Sweden.
    Telomere maintenance, a hallmark of cancer for cell immortalization, is commonly achieved by telomerase activation through induction of the telomerase reverse transcriptase (TERT) gene. Pheochromocytomas (PCC) and abdominal paragangliomas (PGL) (together PPGL) are endocrine tumours for which TERT promoter mutations and telomerase activation have been previously reported [1]. Only 10-15% of PPGL metastasize, however in the absence of metastases, the identification of malignant disease is a diagnostic dilemma. Read More

    Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in patients with adrenal adenomas.
    Clin Endocrinol (Oxf) 2017 Nov 8. Epub 2017 Nov 8.
    Department of Endocrinology, Metabolism University Hospital of Patras, Greece.
    Context: Abdominal visceral adiposity and central sarcopenia are markers of increased cardiovascular risk and mortality.

    Objective: To assess whether central sarcopenia and adiposity can serve as a marker of disease severity in patients with adrenal adenomas and glucocorticoid secretory autonomy.

    Design: Retrospective cohort study. Read More

    Circulating B-type Natriuretic Peptide in Women with and without Recent Gestational Diabetes:The Impact of Current Glucose Intolerance.
    Clin Endocrinol (Oxf) 2017 Nov 7. Epub 2017 Nov 7.
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada.
    Context: Circulating B-type natriuretic peptide, as measured by the N-terminal fragment of its prohormone (NT-proBNP), is inversely associated with incident type 2 diabetes (T2DM) but positively related to future cardiovascular disease (CVD). Recognizing that gestational diabetes (GDM) identifies women at future risk for both T2DM and CVD, we sought to determine whether gestational glucose tolerance relates to NT-proBNP in the years after delivery.

    Design/patients/measurements: Three-hundred-and-forty women underwent a glucose challenge test (GCT) and an oral glucose tolerance test (OGTT) in pregnancy, yielding 4 gestational glucose tolerance groups: GDM (n=105); gestational impaired glucose tolerance (n=59); abnormal GCT with a normal OGTT (n=98); and normal GCT with normal OGTT (n=75). Read More

    Associations of lifestyle factors with serum dehydroepiandrosterone sulfate and insulin-like growth factor-1 concentration in prepubertal children.
    Clin Endocrinol (Oxf) 2017 Nov 7. Epub 2017 Nov 7.
    Department of Physiology, Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
    Objective: Little is known about the relationships of dietary factors, physical activity, and sedentary behavior to dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEAS and IGF-1 in children.

    Design And Subjects: Cross-sectional analysis of a population sample of 431 prepubertal children aged 6-9 years. Read More

    Use of salivary cortisol and cortisone in the high and low dose synacthen test.
    Clin Endocrinol (Oxf) 2017 Nov 6. Epub 2017 Nov 6.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
    Context: Salivary cortisone reflects serum cortisol levels, is more sensitive than salivary cortisol at lower values of serum cortisol and is non-invasive.

    Objective: To investigate the relationship between serum cortisol and salivary cortisol and cortisone following low and high-dose synacthen.

    Design And Setting: Prospective pharmacodynamic studies in clinical research facilities. Read More

    Clinical guidance for Radioiodine Refractory Differentiated Thyroid Cancer.
    Clin Endocrinol (Oxf) 2017 Nov 2. Epub 2017 Nov 2.
    Department of Diabetes, EndocrinologyMetabolism, Royal North Shore Hospital Sydney, Australia.
    Prognosis from differentiated thyroid cancer is worse when the disease becomes refractory to radioiodine. Until recently, treatment options have been limited to local therapies such as surgery and radiotherapy, but the recent availability of systemic therapies now provides some potential for disease control. Multi-targeted kinase inhibitors (TKIs) including lenvatinib and sorafenib have been shown to improve progression free survival in Phase III clinical trials, but are also associated with a spectrum of adverse effects. Read More

    Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized Control Trial.
    Clin Endocrinol (Oxf) 2017 Nov 2. Epub 2017 Nov 2.
    Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, 110029, New Delhi.
    Background: Cholecalciferol and/or calcium supplementation might increase skeletal-muscle strength and serum testosterone in young adult males.

    Objective: We performed a randomized-control-trial assessing the effect of cholecalciferol/calcium on skeletal-muscle strength and serum testosterone in vitamin-D deficient young males.

    Design: Two-by-two factorial RCT. Read More

    Risk Factors stratifying malignancy of nodules in contralateral thyroid lobe in patients with preoperative ultrasound indicated unilateral papillary thyroid carcinoma: A retrospective analysis from single center.
    Clin Endocrinol (Oxf) 2017 Oct 30. Epub 2017 Oct 30.
    Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Objective: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma with a favorable clinical outcome. For unilateral PTC patients with thyroid nodules in the contralateral lobes, the necessity of total thyroidectomy (TT) is still in doubt. In this study, we aimed to define clinical factors that could be indicators for malignancy in nodules in the contralateral thyroid lobe, which could aid the clinician in selecting the appropriate operation approach. Read More

    Tumour Lateralization in Cushing's disease by Inferior Petrosal Sinus Sampling with desmopressin.
    Clin Endocrinol (Oxf) 2017 Oct 28. Epub 2017 Oct 28.
    Department of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, China.
    Background: Bilateral inferior petrosal sinus sampling (IPSS) with corticotropin-releasing hormone (CRH) is currently the gold standard in the diagnosis of Cushing's disease (CD) and has also been used in tumour lateralization. Our objective was to determine the diagnostic value and lateralization accuracy of IPSS with desmopressin.

    Methods: We retrospectively analyzed 91 patients with Cushing's syndrome who had either negative findings on pituitary dynamic enhanced magnetic resonance imaging (MRI) or non-suppressed high dose dexamethasone suppression tests (HDDST). Read More

    Bone mineral density in familial partial lipodystrophy.
    Clin Endocrinol (Oxf) 2017 Oct 27. Epub 2017 Oct 27.
    UETeM-Molecular Pathology Group, Department of Medicine, IDIS-CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.
    Objective: Type 1 and type 2 familial partial lipodystrophies (FPLD) are characterized by the loss or increase in subcutaneous fat in certain body regions, as well as metabolic disorders. Higher muscle volume and mass have also been described. However, so far, possible bone involvement has not been studied. Read More

    Double trouble: Co-occurrence of testosterone deficiency and body fatness associated with all-cause mortality in US men.
    Clin Endocrinol (Oxf) 2017 Oct 25. Epub 2017 Oct 25.
    Division of Urology, UTHealth McGovern Medical School, Houston, TX, USA.
    Background: Testosterone deficiency (TD, total testosterone ≤350 ng/dL [12.15 nmol L(-1) ]) and obesity epidemic are growing in parallel in the United States. Yet, the sequelae of TD and obesity on the risk of mortality remain unclear. Read More

    Long-term safety of growth hormone-A combined registry analysis.
    Clin Endocrinol (Oxf) 2017 Oct 21. Epub 2017 Oct 21.
    Department of Women and Child Health, Hospital for Children and Adolescents, University Hospitals, University of Leipzig, Leipzig, Germany.
    Objectives: Preliminary data from the French cohort of the Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) study raised concerns regarding the safety of recombinant human GH, suggesting that GH may increase mortality and incidence of stroke in patients treated during childhood for GH deficiency or short stature. We evaluated published safety data, focusing on mortality, neoplasms, cerebrovascular events and diabetes across a number of large-scale pharmaceutical company GH registries.

    Design: A literature review was conducted using PubMed, EMBASE and Google Scholar to identify all relevant safety data from manufacturers' GH registries published between 1988 and April 2016. Read More

    An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study.
    Clin Endocrinol (Oxf) 2017 Oct 17. Epub 2017 Oct 17.
    Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime, Japan.
    Objective: Resistin is secreted by monocytes/macrophages and is associated with insulin resistance, inflammation and cardiovascular diseases. In the Japanese cohort, serum resistin is tightly associated with a single-nucleotide polymorphism (SNP) at -420 (rs1862513) in the promoter region of the human resistin gene. However, interactions between SNP-420 and environmental factors remain to be elucidated. Read More

    Males with prolactinoma are at increased risk of incident cardiovascular disease.
    Clin Endocrinol (Oxf) 2017 Oct 16. Epub 2017 Oct 16.
    Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
    Objective: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma.

    Design: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database.

    Patients: A total of 2233 patients with prolactinoma and 10 355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Read More

    Women with polycystic ovary syndrome demonstrate worsening markers of cardiovascular risk over the short-term despite declining hyperandrogenaemia: Results of a longitudinal study with community controls.
    Clin Endocrinol (Oxf) 2017 Dec;87(6):775-782
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco School of Medicine, San Francisco, CA, USA.
    Objective: To compare age-associated changes in cardiovascular risk markers in lean and obese reproductive-aged women with polycystic ovary syndrome (PCOS) with community controls.

    Design: Longitudinal study at an academic medical centre PATIENTS: Patients diagnosed with PCOS by 2004 Rotterdam criteria in a multidisciplinary clinic were systematically enrolled from 2006-2014 in a PCOS cohort study and subsequently agreed to participate in a longitudinal study. The comparison controls were from the prospective, longitudinal Ovarian Aging (OVA) study, which consists of healthy women with regular menstrual cycles recruited from 2006 to 2011. Read More

    Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1.
    Clin Endocrinol (Oxf) 2017 Oct 16. Epub 2017 Oct 16.
    School of Medicine, University of Western Australia, Perth, WA, Australia.
    Objective: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. Read More

    Gain-of-function mutations in G-protein-coupled receptor genes associated with human endocrine disorders.
    Clin Endocrinol (Oxf) 2017 Oct 13. Epub 2017 Oct 13.
    Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    The human genome encodes more than 700 G-protein-coupled receptors (GPCRs), many of which are involved in hormone secretion. To date, more than 100 gain-of-function (activating) mutations in at least ten genes for GPCRs, in addition to several loss-of-function mutations, have been implicated in human endocrine disorders. Previously reported gain-of-function GPCR mutations comprise various missense substitutions, frameshift mutations, intragenic inframe deletions and copy-number gains. Read More

    Weight gain after treatment of Graves' disease in children.
    Clin Endocrinol (Oxf) 2017 Oct 12. Epub 2017 Oct 12.
    UT Southwestern Medical Center, Dallas, TX, USA.
    Objective: The frequency of and risk factors for weight gain in children treated for Graves' disease have not been described. We evaluated change in BMI-Z score and predictors of weight gain in this population.

    Design: Retrospective review of data from January 2000 to July 2011. Read More

    Hyperthyroidism in patients with ischaemic heart disease after iodine load induced by coronary angiography: Long-term follow-up and influence of baseline thyroid functional status.
    Clin Endocrinol (Oxf) 2017 Oct 12. Epub 2017 Oct 12.
    Division of Endocrinology, Diabetology, and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.
    Objective: To study the effect of a iodine load on thyroid function of patients with ischaemic heart disease (IHD) and the long-term influence of unknown subclinical hyperthyroidism.

    Context: Subclinical hyperthyroidism is considered an independent risk factors for cardiovascular morbidity of patients with IHD. They routinely undergo coronary angiography with iodine contrast media (ICM) which may induce or even worsen hyperthyroidism. Read More

    Antibiotics, gut microbiome and obesity.
    Clin Endocrinol (Oxf) 2017 Oct 12. Epub 2017 Oct 12.
    Liggins Institute, University of Auckland, Auckland, New Zealand.
    Antibiotics have been hailed by many as "miracle drugs" that have been effectively treating infectious diseases for over a century, leading to a marked reduction in morbidity and mortality. However, with the increasing use of antibiotics, we are now faced not only with the increasing threat of antibiotic resistance, but also with a rising concern about potential long-term effects of antibiotics on human health, including the development of obesity. The obesity pandemic continues to increase, a problem that affects both adults and children alike. Read More

    Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.
    Clin Endocrinol (Oxf) 2017 Oct 4. Epub 2017 Oct 4.
    Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle Upon Tyne, UK.
    Postmenopausal hyperandrogenism can be tumour- or non-tumour-related, with pathology residing either in the ovary or adrenal gland(s). The tempo of investigation is determined by the clinical severity of hyperandrogenism (presence/absence of actual virilisation) and degree of serum testosterone elevation. When clinical or biochemical hyperandrogenism is severe, rapidly developing, or associated with hypercortisolism, screening for adrenocortical or ovarian carcinoma with cross-sectional imaging should be prioritised over detailed biochemical evaluation. Read More

    Disagreement in normative IGF-I levels may lead to different clinical interpretations and GH dose adjustments in GH deficiency.
    Clin Endocrinol (Oxf) 2017 Oct 4. Epub 2017 Oct 4.
    Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands.
    Introduction And Background: Normative data for the iSYS IGF-I assay have been published both in the VARIETE cohort and by Bidlingmaier et al.

    Objective: To investigate whether normative data of the VARIETE cohort lead to differences in Z-scores for total IGF-I and clinical interpretation compared to normative data of Bidlingmaier et al.

    Design: We used total IGF-I values previously measured by the IDS-iSYS assay in 102 GH-deficient subjects before starting GH treatment and after 12 months of GH treatment. Read More

    Decrease in salivary cortisol levels after glucocorticoid dose reduction in patients with adrenal insufficiency: A prospective proof-of-concept study.
    Clin Endocrinol (Oxf) 2017 Oct 3. Epub 2017 Oct 3.
    Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy.
    Background And Aim: Patients with adrenal insufficiency (AI) require lifelong glucocorticoid (GC) replacement therapy. Cortisol measurement in saliva is increasingly being used: we assessed salivary cortisol rhythm in outpatients with AI, to provide new insights regarding the management of GC treatment.

    Materials And Methods: Nineteen AI outpatients collected six saliva samples from awakening (F(a) , before taking the morning GC therapy), during the day (F(1. Read More

    Prognostic indicators of outcomes in patients with lung metastases from differentiated thyroid carcinoma during long-term follow-up.
    Clin Endocrinol (Oxf) 2017 Oct 3. Epub 2017 Oct 3.
    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Distant metastases, although uncommon, represent maximum disease-related mortality in differentiated thyroid carcinoma (DTC). Lungs are the most frequent sites of metastases. We aimed to evaluate long-term outcomes and identify prognostic factors in metastatic DTC limited to the lungs. Read More

    The effects of low-dose human chorionic gonadotropin combined with human menopausal gonadotropin protocol on women with hypogonadotropic hypogonadism undergoing ovarian stimulation for in vitro fertilization.
    Clin Endocrinol (Oxf) 2017 Sep 27. Epub 2017 Sep 27.
    Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Objectives: To investigate the effects of low-dose human chorionic gonadotropin (hCG) combined with human menopausal gonadotropin (HMG) protocol on cycle characteristics and outcomes of infertile women with hypogonadotropic hypogonadism (HH) undergoing ovarian stimulation for in vitro fertilization (IVF).

    Design: A retrospective cohort study.

    Setting: Tertiary-care academic medical centre. Read More

    Increased prevalence of fracture and hypoglycaemia in young adults with concomitant type 1 diabetes mellitus and coeliac disease.
    Clin Endocrinol (Oxf) 2017 Sep 28. Epub 2017 Sep 28.
    Departments of Endocrinology and Diabetes, Monash Health, Clayton, Vic., Australia.
    Background: Both Type 1 diabetes mellitus (T1DM) and coeliac disease (CD) are independently associated with reduced bone mineral density (BMD) and increased fracture risk. Whilst poorer glycaemic control and increased microvascular complications have been described, the literature examining bone health and fractures in adults with concomitant T1DM and CD (T1DM + CD) is limited.

    Objective: To evaluate fracture prevalence and explore associations with glycaemic control, hypoglycaemia and microvascular disease in T1DM + CD compared with T1DM alone. Read More

    Multicentre clinical evaluation of the new highly sensitive Elecsys® thyroglobulin II assay in patients with differentiated thyroid carcinoma.
    Clin Endocrinol (Oxf) 2017 Sep 28. Epub 2017 Sep 28.
    Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
    Objective: A highly sensitive thyroglobulin assay (Elecsys® Tg II, Roche Diagnostics, Penzberg, Germany) has become available for monitoring patients with differentiated thyroid cancer (DTC). Here, we evaluated the clinical performance of Elecsys® Tg II assay in a multicentre patients series and compare it with the established Access® Tg assay (Beckman Coulter, Brea, CA, USA).

    Design: Retrospective analysis on prospectively selected patients in four thyroid cancer referral centres with uniform DTC management. Read More

    Serum 25-hydroxyvitamin D as a predictor of mortality and cardiovascular events: A 20-year study of a community-based cohort.
    Clin Endocrinol (Oxf) 2017 Sep 26. Epub 2017 Sep 26.
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
    Objective: Prospective studies, mostly from Europe and North America, suggest that serum 25-hydroxyvitamin D (25(OH)D) is inversely associated with mortality and cardiovascular disease (CVD) risk. Data from other regions are limited, and threshold levels for adverse cardiovascular outcomes are uncertain. We examined serum 25(OH)D as a predictor of total mortality and cardiovascular outcomes in an Australian cohort. Read More

    Parathyroid hormone: Data mining for age-related reference intervals in adults.
    Clin Endocrinol (Oxf) 2017 Sep 26. Epub 2017 Sep 26.
    Department of Clinical Chemistry, Laverty Pathology, North Ryde, NSW, Australia.
    Objective: Age-related changes in parathyroid hormone (PTH) have been previously documented in adults. However, because of the limitations of traditional approaches to establishing reference intervals, age-related reference intervals have not been defined. We sought to use a data mining approach to derive age-related PTH reference intervals. Read More

    Progressive impairment of testicular endocrine function in ageing men: Testosterone and dihydrotestosterone decrease, and luteinizing hormone increases, in men transitioning from the 8th to 9th decades of life.
    Clin Endocrinol (Oxf) 2017 Sep 25. Epub 2017 Sep 25.
    School of Medicine, University of Western Australia, Perth, WA, Australia.
    Context: Sex hormone trajectories in ageing men and their health implications remain unclear. We examined longitudinal trajectories and associations of testosterone (T), dihydrotestosterone (DHT), oestradiol (E2), luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) in oldest old men.

    Design: Prospective cohort study. Read More

    Endocrinopathies with use of cancer immunotherapies.
    Clin Endocrinol (Oxf) 2017 Sep 23. Epub 2017 Sep 23.
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
    Background: Immunomodulatory therapies, including CTLA-4 and PD-1 inhibitors, provide a directed attack against cancer cells by preventing T cell deactivation. However, these drugs also prevent the downregulation of auto-reactive T cells, resulting in immune-related adverse events (IRAEs). Reports show a varied incidence of endocrine IRAEs, ranging from 0% to 63%. Read More

    Autoantibodies against the calcium-sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3 and 4.
    Clin Endocrinol (Oxf) 2017 Sep 23. Epub 2017 Sep 23.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
    Objective: The frequency of autoimmunity against the parathyroid glands in patients with polyglandular autoimmunity that is not due to autoimmune polyendocrine syndrome type 1 (APS1) is unclear. To investigate this, this study aimed to determine the prevalence of autoantibodies against parathyroid autoantigens, calcium-sensing receptor (CaSR) and NACHT leucine-rich-repeat protein 5 (NALP5), in a large group of patients with non-APS1 polyendocrine autoimmunity. Possible occult APS1 was investigated by cytokine autoantibody measurement and AIRE gene analysis. Read More

    Clinical features and prognosis of thymic neuroendocrine tumours associated with multiple endocrine neoplasia type 1: A single-centre study, systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2017 Dec 16;87(6):706-716. Epub 2017 Oct 16.
    Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
    Objective: Thymic neuroendocrine tumour (TH-NET) accounts for almost 20% of multiple endocrine neoplasia type 1 (MEN1)-associated mortality. Identifying risk factors for the development of these rare tumours and prognostic factors for clinical outcomes will be helpful in clinical practice.

    Design And Patients: We performed a retrospective analysis of patients treated for TH-NET associated with MEN1 in a single institution and meta-analysis of literature reports. Read More

    The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2017 Sep 20. Epub 2017 Sep 20.
    Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background And Objective: Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder associated with metabolic syndrome (MetS). The aim of this systematic review and meta-analysis was to provide the most reliable estimate risk of MetS in women with PCOS, compared to healthy controls.

    Methods: A comprehensive literature search was performed in PubMed [including Medline], Web of Science and Scopus databases for retrieving articles in English language on the prevalence/incidence and odds of MetS in women with PCOS compared to healthy controls. Read More

    Primary hyperparathyroidism: Dynamic postoperative metabolic changes.
    Clin Endocrinol (Oxf) 2017 Sep 14. Epub 2017 Sep 14.
    Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.
    Objective: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated.

    Design: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intra-operatively, at postoperative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6. Read More

    Influence of coexistent Hashimoto's thyroiditis on the extent of cervical lymph node dissection and prognosis in papillary thyroid carcinoma.
    Clin Endocrinol (Oxf) 2017 Sep 14. Epub 2017 Sep 14.
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objective: Previous studies did not focus on the differences in the extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) in patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed to determine whether extensive cervical LN dissection is responsible for favourable clinical outcomes in PTC patients with HT and whether the coexistence of HT itself has an independent protective effect regardless of LN status.

    Design: Retrospective cohort study. Read More

    Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results.
    Clin Endocrinol (Oxf) 2017 Sep 12. Epub 2017 Sep 12.
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
    Objective: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP.

    Context: Recently, it has been proposed that that noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumours, rather than cancer.

    Patients: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20. Read More

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