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    12841 results match your criteria Clinical endocrinology[Journal]

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    Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism.
    Clin Endocrinol (Oxf) 2018 Feb 21. Epub 2018 Feb 21.
    Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
    Context: The current Endocrine Society Guideline suggests that patients aged <35 years with marked primary aldosteronism (PA) and unilateral adrenal lesions on adrenal computed tomography (CT) scan may not need adrenal vein sampling (AVS) before proceeding to unilateral adrenalectomy. This suggestion is, however, based on the data from only one report in the literature.

    Objective: We sought to determine the accuracy of CT findings in young PA patients who had unilateral adrenal disease on CT with hypokalaemia and elevation of aldosterone. Read More

    Heterozygous aggrecan variants are associated with short stature and brachydactyly: Description of 16 probands and a review of the literature.
    Clin Endocrinol (Oxf) 2018 Feb 21. Epub 2018 Feb 21.
    Institute of Medical and Molecular Genetics (INGEMM), Hospital Universitario La Paz, Universidad Autonóma de Madrid, IdiPAZ, Madrid, Spain.
    Objective: Mutations in the aggrecan gene (ACAN) have been identified in two autosomal dominant skeletal dysplasias, Spondyloepiphyseal dysplasia, Kimberley type (SEDK) and osteochondritis dissecans, as well as in a severe recessive dysplasia, Spondyloepimetaphyseal dysplasia, aggrecan type. Next generation sequencing (NGS) has aided the identification of heterozygous ACAN mutations in individuals with short stature, minor skeletal defects and mild facial dysmorphisms, some of whom have advanced bone age (BA), poor pubertal spurt and early growth cessation as well as precocious osteoarthritis.

    Design & Methods: Clinical and genetic characterization of 16 probands with heterozygous ACAN variants, 14 with short stature and mild skeletal defects (group 1) and two with SEDK (group 2). Read More

    Copeptin role in polyuria-polydipsia syndrome (PPS) differential diagnosis and reference range in paediatric age.
    Clin Endocrinol (Oxf) 2018 Feb 21. Epub 2018 Feb 21.
    Department of Paediatric Endocrinology, Regina Margherita Children's Hospital, Department of Public Health and Paediatric Sciences, University of Turin.
    Objective: Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age.

    Patients And Methods: Plasma copeptin levels were evaluated in 53 children without AVP disorders (control population), in 12 hypopituitaric children and in 15 patients with PPS after water deprivation test (WDT). Read More

    Progressive osseous heteroplasia caused by a mosaic gnas mutation.
    Clin Endocrinol (Oxf) 2018 Feb 21. Epub 2018 Feb 21.
    Molecular (Epi)Genetics Laboratory, BioAraba National Health Institute, OSI Araba University Hospital, Vitoria-Gasteiz, Spain.
    Progressive osseous heteroplasia (POH, OMIM#166350) is an "ultrarare" genetic condition characterized by plaque-like heterotopic ossification, beginning in infancy in the dermis and subsequently progressing to involve deep connective tissues such as muscles and joints, sometimes resulting in loss of mobility. It is usually associated with paternal inheritance of an inactivating mutation at the GNAS gene but in some patients (around 30% of cases) with identical clinical characteristics of POH no mutations have been detected. On the other hand, the same mutation on the paternal allele can be responsible for pseudopseudohypoparathyroidism (PPHP, OMIM#612463), or, if maternally inherited, pseudohypoparathyroidism type 1A (PHP1A, OMIM#103580)This article is protected by copyright. Read More

    Bone mineral density and body composition in children with congenital adrenal hyperplasia.
    Clin Endocrinol (Oxf) 2018 Feb 20. Epub 2018 Feb 20.
    Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
    Background: Children with congenital adrenal hyperplasia (CAH) are exposed to fluctuating cortisol and androgen levels. The effects these hormonal states have on bone mineral density (BMD) and body composition are not well studied.

    Objective: Compare BMD and body composition, including visceral adipose tissue (VAT) and Android:Gynoid (A:G) ratio, in children with CAH vs. Read More

    Time for change: Renaming Diabetes Insipidus to improve patient safety?
    Clin Endocrinol (Oxf) 2018 Feb 20. Epub 2018 Feb 20.
    Croydon University Hospital Ringgold standard institution, Department of Endocrinology, Croydon, United Kingdom of Great Britain and Northern Ireland.
    Diabetes Insipidus (DI) is a name given historically to two conditions, which result in 'diabetes', which is Greek for 'syphon' or polyuria. The "Insipidus" refers to urine being insipid. 'Cranial DI' is so called because it relates to a cause within the head characterised by deficiency of vasopressin [antidiuretic hormone (ADH)] secretion from the posterior pituitary. Read More

    Polycystic ovary syndrome and adverse pregnancy outcomes: current state of knowledge, challenges and potential implications for practice.
    Clin Endocrinol (Oxf) 2018 Feb 20. Epub 2018 Feb 20.
    Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, VIC, Australia.
    Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Read More

    Pregnancy on vandetanib in metastatic medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2B.
    Clin Endocrinol (Oxf) 2018 Feb 19. Epub 2018 Feb 19.
    Department of Endocrinology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
    Vandetanib is a tyrosine kinase inhibitor (TKI) used in the treatment of medullary thyroid carcinoma occurring in >95% of patients with multiple endocrine neoplasia type 2b (MEN 2b). Pregnancy in women with MEN 2b on vandetanib is previously unreported and has multiple potential implications for both the mother and developing fetus [1]. We describe the case of a 22 year old woman with a background of MEN 2b who was first diagnosed aged 6 presenting with marfanoid habitus, and oral mucosal neuromas. Read More

    The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study.
    Clin Endocrinol (Oxf) 2018 Feb 17. Epub 2018 Feb 17.
    Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
    Objective: Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between THs and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum THs levels within the reference range are predictive factors for developing MetS in adults. Read More

    Impact of TSH during the first trimester of pregnancy on obstetric and fetal complications: Usefulness of 2.5 mIU/L cut-off value.
    Clin Endocrinol (Oxf) 2018 Feb 17. Epub 2018 Feb 17.
    Endocrinology and Nutrition Department. Hospital, Universitari Germans Trias i Pujol, Badalona, Spain.
    Objective: An association of pregnancy outcomes with subclinical hypothyroidism has been reported, however there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The objective of the study was to evaluate the association of fetal-maternal complications with first trimester maternal TSH values.

    Design: A retrospective study in a single tertiary care hospital was performed. Read More

    The HDL anti-inflammatory function is impaired in the context of low-normal free thyroxine in diabetic and non-diabetic individuals.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands.
    Differences in thyroid function status within the euthyroid range have been proposed to affect the development of (subclinical) atherosclerosis [1], as evidenced by a greater carotid artery intima media thickness and progression of coronary artery calcification in the context of low normal thyroid function, i.e. a higher thyroid stimulating hormone (TSH) or a lower free thyroxine (FT4) thyroid hormone in the euthyroid range [2,3]. Read More

    Body fat content, fat distribution and adipocytokine production and their correlation with fertility markers in young adult men and women conceived by ICSI.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Department of Human Anatomy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.
    Objective: Differences in body fat content during childhood and adolescence have been described in offspring conceived by In Vitro Fertilisation (IVF) and Intracytoplasmic Sperm Injection (ICSI). However, data on body fat and its distribution as well as on adipocytokine production in young adults conceived by ICSI are non-existent. We investigated if young adult men and women conceived by ICSI have a normal body fat patterning and adipocytokine production. Read More

    An assessment ofF-FDG PET/CT for thoracic screening and risk stratification of Pulmonary Nodules in Multiple Endocrine Neoplasia Type 1.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Department of Diabetes & Endocrinology, Royal Hobart Hospital, 48 Liverpool Street, Hobart, Tasmania, 7000, Australia.
    Context: Bronchopulmonary neuroendocrine tumours (bpNETs) and thymic carcinoid (ThC) are features of Multiple Endocrine Neoplasia Type 1 (MEN 1) and surveillance guidelines recommend periodic thoracic imaging. The optimal thoracic imaging modality and screening frequency remains uncertain as does the prognosis of small lung nodules when identified.

    Objectives: To evaluate fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for identification and prognostic assessment of thoracic lesions in MEN 1. Read More

    Injection Testosterone and Adverse Cardiovascular Events: A Case-crossover Analysis.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Department of Epidemiology, University of North Carolina at Chapel Hill.
    Context: Exogenous testosterone administration may affect blood clotting, polycythemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms.

    Objective: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone. Read More

    Novel Insights on Testicular Volume and Testosterone Replacement Therapy in Klinefelter Patients Undergoing Testicular Sperm Extraction. A Retrospective Clinical Study.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Department of Medicine, University of Padova, Unit of Andrology and Reproductive Medicine, Via Gustavo Modena 9, 35121, Padova, Italy.
    Study Question: To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS).

    Summary Answer: This study provides three interesting insights: i) the probability to retrieve sperm is not related to testicular volume; ii) TRT does not affect sperm retrieval rate (SRR); iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT.

    What Is Known Already: Classical KS shows a karyotype with one extra X chromosome in all of somatic cells and clinical manifestations characterized by hypergonadotropic hypogonadism and infertility. Read More

    Clinical parameters of ovarian hyperstimulation syndrome (OHSS) following different hormonal triggers of oocyte maturation in IVF treatment.
    Clin Endocrinol (Oxf) 2018 Feb 15. Epub 2018 Feb 15.
    Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.
    Objective: Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of OHSS. However to date, the safety of kisspeptin has not been compared to current hormonal triggers of oocyte maturation. Read More

    Bone mineral density in young adults with Prader-Willi syndrome: a randomized, placebo-controlled, cross-over GH trial.
    Clin Endocrinol (Oxf) 2018 Feb 8. Epub 2018 Feb 8.
    Dutch Growth Research Foundation, Rotterdam, The Netherlands.
    Context: The prevalence of osteoporosis is increased in adults with Prader-Willi syndrome (PWS). In children with PWS, growth hormone (GH) treatment has beneficial effects on bone mineral density (BMD). BMD might deteriorate after cessation of GH at adult height (AH), while continuing GH might maintain BMD. Read More

    HLA coeliac haplotypes and Primary Autoimmune Hypophysitis in Caucasian patients.
    Clin Endocrinol (Oxf) 2018 Feb 8. Epub 2018 Feb 8.
    Department of Endocrinology, Catholic University School of Medicine, Largo Agostino Gemelli, 8, 00168, Rome, Italy.
    Purpose: Primary hypophysitis is a rare disease, with an autoimmune etiology. As few papers have investigated its genetic, our aim was to evaluate HLA status in a single-center series of patients.

    Patients And Method: A retrospective, longitudinal and cross-sectional study was conducted. Read More

    Establishment of MRI 3D Reconstruction Technology of Orbital Soft Tissue and Its Preliminary Application in Patients with Thyroid-Associated Ophthalmopathy.
    Clin Endocrinol (Oxf) 2018 Feb 7. Epub 2018 Feb 7.
    Department of Anatomy, Southern Medical University School of Basic Medical Science, Guangzhou, 510515, China.
    Objective: Effective management of thyroid-associated ophthalmopathy (TAO) requires precise identification of the disease activity period as it is responsive to immunosuppressive treatment. Quantitative evaluations of orbital soft tissue is useful for analysing disease stages. We aimed to establish a method for orbital soft tissue volume calculation based on MRI data using 3D reconstruction technology. Read More

    Sex-dependent reductions in high-molecular weight adiponectin during acute hyperinsulinemia are prevented with endurance training in older females.
    Clin Endocrinol (Oxf) 2018 Feb 7. Epub 2018 Feb 7.
    Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, 45701, USA.
    Objective: The high molecular weight (HMW) adiponectin isoform is considered the active form of adiponectin and is linked to insulin sensitivity and the reduced risk of developing cardiovascular disease. The purpose of the first study was to determine the effects of age and sex on the plasma HMW adiponectin response to acute hyperinsulinemia, and secondly determine if either endurance or resistance exercise training could affect this response.

    Design And Participants: Twenty-six, healthy males (19-84 years) and twenty-six, healthy females (18-76 years) were recruited and matched for BMI to examine the effects of sex and age on the plasma adiponectin response to a 2 hour hyperinsulinemic-euglycemic clamp. Read More

    Cortisol evaluation during the acute phase of traumatic brain injury - a prospective study.
    Clin Endocrinol (Oxf) 2018 Feb 5. Epub 2018 Feb 5.
    Endocrinology unit, Central Hospital of Army Algiers, Algeria.
    Background: Biochemical diagnosis of adrenal insufficiency (AI) is difficult in the context of traumatic brain injury (TBI) AIM: to assess the frequency and predictive factors of AI in victims of TBI from Algiers.

    Methods: Between November 2009 and December 2013, TBI victims had a single 8-9 a.m. Read More

    The Free Androgen Index is inaccurate in women when the SHBG concentration is low.
    Clin Endocrinol (Oxf) 2018 Feb 5. Epub 2018 Feb 5.
    Department of Clinical Chemistry, Ghent University Hospital, Belgium.
    Objective/context: The free androgen index (FAI) is known to give erroneous results in men but it is still a commonly used test for the investigation of hyperandrogenism in women. This study aimed to compare the results of the FAI with the gold standard equilibrium dialysis method for free testosterone in women.

    Design/patients: Free serum testosterone T (ED-T) and total serum T (T) were measured by equilibrium dialysis and LC-MS/MS in patients with polycystic ovarian syndrome (n=130), normal female controls (n=53) and normal males (n=120). Read More

    Retinol-binding protein 4 is positively associated with bone mineral density in osteopenia and osteoporosis type 2 diabetic patients.
    Clin Endocrinol (Oxf) 2018 Feb 2. Epub 2018 Feb 2.
    Department of Endocrinology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical, Yantai, Shandong, China.
    Objective: This study intends to study the association between serum retinol-binding protein 4 (RBP4), bone mineral density (BMD), and other bone metabolic related parameters in type 2 diabetic patients older than 50 years, with or without osteopenia or osteoporosis.

    Methods: Patients (n = 274 cases) with type 2 diabetes, hospitalized in the Endocrinology Department of Yantai Yuhuangding Hospital from December 2015 to March 2017, were enrolled in the study. The bone mineral density (BMD) was recorded by the dual-energy X-ray absorptiometer, and patients were divided into normal bone mineral density group (148 cases), osteopenia (93 cases), and osteoporosis group (33 cases) group. Read More

    International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen.
    Clin Endocrinol (Oxf) 2018 Feb 2. Epub 2018 Feb 2.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
    Objective: The short synacthen test (SST) is widely used to assess patients for adrenal insufficiency, but the frequency and protocols used across different centres for the low-dose test (LDT) are unknown. This study aimed to survey centres and test the accuracy of ten different synacthen preparation strategies used for the LDT.

    Methods: Members of 6 international endocrine societies were surveyed regarding diagnostic tests used for adrenal insufficiency, and in particular the SST. Read More

    Changes in bone mineral density and bone turnover markers during treatment with teriparatide in pregnancy- and lactation-associated osteoporosis.
    Clin Endocrinol (Oxf) 2018 Feb 1. Epub 2018 Feb 1.
    Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Context: Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum.

    Objective: To investigate the changes in bone mineral density (BMD) and bone turnover markers in patients with PLO with and without TPTD treatment.

    Design: Retrospective cohort study. Read More

    Higher level of GGT during mid-pregnancy is associated with increased risk of gestational diabetes mellitus.
    Clin Endocrinol (Oxf) 2018 Jan 31. Epub 2018 Jan 31.
    Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Objective: This study was to explore the link between gamma-glutamyl transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) levels during early-middle pregnancy and subsequent risk of gestational diabetes mellitus (GDM).

    Methods: In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT, AST and ALT levels were tested during weeks 14-18 of gestation and oral glucose tolerance test was conducted during 24-28 weeks to screen GDM. Read More

    Improved insulin sensitivity and secretion in prediabetic patients with adrenal insufficiency on dual-release hydrocortisone treatment: a 36-month retrospective analysis.
    Clin Endocrinol (Oxf) 2018 Jan 25. Epub 2018 Jan 25.
    Biomedical Department of Internal and Specialist Medicine (DIBIMIS), Section of Diabetes, Endocrinology and Metabolism, University of Palermo, Palermo, Italy.
    Objective: Dual-release hydrocortisone (DR-HC) provides physiological cortisol exposure, leading to an improvement of anthropometric and metabolic parameters. The aim of the study was to evaluate the effects of DR-HC on insulin secretion and sensitivity and cardiometabolic risk, indirectly expressed by the visceral adiposity index (VAI).

    Design And Patients: Retrospective analysis of 49 patients, 13 with primary and 36 with secondary adrenal insufficiency (AI), respectively, on conventional glucocorticoid treatment at baseline and switched to DR-HC for 36 months. Read More

    Serum irisin concentrations in lean adolescents with polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2018 Jan 25. Epub 2018 Jan 25.
    Division of Pediatric-Adolescent Gynecology and Reconstructive Surgery, Second Department of Obstetrics and Gynecology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece.
    Objective: To explore differences in irisin concentrations between lean adolescents with PCOS and age- and body mass index (BMI)-matched controls and examine the associations of irisin with core features of the syndrome.

    Design: Cross-sectional study.

    Patients: Lean females with PCOS, aged 13-21 years. Read More

    Delayed initial radioiodine therapy related to incomplete response in low- to intermediate-risk differentiated thyroid cancer.
    Clin Endocrinol (Oxf) 2018 Jan 16. Epub 2018 Jan 16.
    Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China.
    Objective: Whether the initiating time of radioiodine (RAI) therapy will affect the clinical outcome in differentiated thyroid cancer (DTC) remains controversial. The objective of this study was to evaluate the impact of RAI therapy initiating time on response to initial therapy in low- to intermediate-risk DTC.

    Methods: A total of 235 consecutive patients with low- to intermediate-risk DTC were retrospectively reviewed. Read More

    Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2018 Jan 11. Epub 2018 Jan 11.
    NIHR Collaboration for Leadership in Applied Health Research and Care South West Peninsula (PenCLAHRC), University of Exeter Medical School, University of Exeter, Exeter, UK.
    Background: In the last 2 decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results.

    Aim: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes. Read More

    Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity.
    Clin Endocrinol (Oxf) 2018 Jan 5. Epub 2018 Jan 5.
    Tommy's Centre for Maternal and Fetal Health, Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
    Objective: Hypothalamic-pituitary-adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid pulsatility in pregnancy. Read More

    Ovarian markers and irregular menses among women with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications study.
    Clin Endocrinol (Oxf) 2018 Mar 26;88(3):453-459. Epub 2018 Jan 26.
    Department of Urology, University of Michigan, Ann Arbor, MI, USA.
    Objective: Women with type 1 diabetes have increased risk of infertility compared to women without diabetes even after adjustment for irregular menses, but aetiologies are incompletely understood. Our aim was to examine the prevalence of abnormalities in ovarian markers consistent with polycystic ovary syndrome in women with type 1 diabetes and associations with irregular menses and diabetes-specific variables.

    Design, Patients And Measurements: We conducted a secondary analysis of women in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), a randomized trial and observational follow-up of intensive insulin therapy for type 1 diabetes. Read More

    Preoperative risk factors for haemodynamic instability during pheochromocytoma surgery in Chinese patients.
    Clin Endocrinol (Oxf) 2018 Mar 25;88(3):498-505. Epub 2018 Jan 25.
    Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Objective: Pheochromocytoma surgery carries a high risk of haemodynamic instability (HI). However, there are few studies investigating the risk factors for HI for pheochromocytoma surgery in a Chinese population. Therefore, our objective was to identify preoperative risk factors for HI during surgery in a Chinese population with pheochromocytoma. Read More

    Meal-related oscillations in the serum serotonin levels in healthy young men.
    Clin Endocrinol (Oxf) 2018 Jan 2. Epub 2018 Jan 2.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
    Context: Serotonin acts as a neurotransmitter in the central and enteric nervous systems, modulating psychological, metabolic and gastrointestinal functions. Serotonin is also found in the serum or plasma, indicating its potential role as a hormone.

    Objective: We aimed to assess the 24-hour diurnal profile of serum serotonin in relation to meal ingestion in healthy adult men. Read More

    Luteinizing hormone and insulin resistance in menopausal patients with adrenal incidentalomas: The cause-effect relationship?
    Clin Endocrinol (Oxf) 2017 Dec 30. Epub 2017 Dec 30.
    Department for Obesity, Reproductive and Metabolic Disorders, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
    Objective: A high prevalence of insulin resistance (IR) has proven to manifest in patients with adrenal incidentalomas (AI). It has been demonstrated that an increase in IR is related to the size of tumourous masses; additionally, luteinizing hormone (LH)-dependent adrenal pathologies are well documented in patients with LH-responsive adrenal tumours occurring under conditions of physiologically elevated LH. We hypothesized that an association between LH and insulin might play a role in adrenal tumourigenesis and steroidogenesis. Read More

    Optimal iodine supplementation during antithyroid drug therapy for Graves' disease is associated with lower recurrence rates than iodine restriction.
    Clin Endocrinol (Oxf) 2018 Mar 23;88(3):473-478. Epub 2018 Jan 23.
    Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
    Objective: A relationship between iodine intake and the effectiveness of antithyroid drug (ATD) therapy for Graves' disease (GD) has been suggested, and strict restriction of iodine intake has been tried in the treatment of GD in some studies. However, it is unclear whether dietary iodine supplementation improves the prognosis of ATD therapy for GD. This study aimed to clarify whether optimal iodine supplementation during antithyroid drug therapy for GD is associated with lower recurrence rates than iodine restriction. Read More

    In women with PCOS, waist circumference is a better surrogate of glucose and lipid metabolism than disease status per se.
    Clin Endocrinol (Oxf) 2017 Dec 29. Epub 2017 Dec 29.
    Department of Endocrinology and Diabetes Mellitus, Tallaght Hospital, Dublin, Ireland.
    Objective: Cardiometabolic abnormalities are recognized in polycystic ovary syndrome (PCOS). However, over-emphasis on PCOS as a risk factor potentially results in over-investigation and treatment of some women with and under-recognition of cardiometabolic risk in obese women without PCOS. Our objective was to explore the association between waist circumference (WC) and indices of glucose and lipid metabolism in women with and without PCOS. Read More

    Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects.
    Clin Endocrinol (Oxf) 2018 Mar 10;88(3):388-396. Epub 2018 Jan 10.
    Laboratory of Atherosclerosis and Vascular Biology, State University of Campinas School of Medicine, UNICAMP, Campinas, SP, Brazil.
    Background: The combinations of adipokines and body mass parameters to estimate carotid atherosclerotic disease have not been completely delineated.

    Objective: To test the combinations of well-established, easily accessible body mass indices and circulating biomarkers to identify increased carotid intima-media thickness (cIMT) in a primary prevention setting.

    Design And Patients: In a cross-sectional analysis of 339 asymptomatic individuals with no history of cardiovascular events, inflammatory and insulin sensitivity biomarkers as well as adipokine levels were measured and combined with body mass parameters to evaluate the best marker for increased cIMT. Read More

    Bethesda thyroid categories and family history of thyroid disease.
    Clin Endocrinol (Oxf) 2018 Mar 21;88(3):468-472. Epub 2018 Jan 21.
    Department of Oncology and Nuclear Medicine, University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.
    Objective: Thyroid cancer is the most common type of endocrine-related cancer worldwide. The aim of this article was to assess the relationship between thyroid diseases diagnosed by fine needle aspiration (FNA) and family history of thyroid disease.

    Design: The study was conducted in a tertiary high-volume thyroid cancer centre. Read More

    Effects of alendronate and alfacalcidol on bone in patients with myasthenia gravis initiating glucocorticoids treatment.
    Clin Endocrinol (Oxf) 2018 Mar 12;88(3):380-387. Epub 2018 Jan 12.
    Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Objective: Glucocorticoids (GCs) are the first-line treatment for myasthenia gravis (MG) and act as long-term immunosuppressants. However, GCs can induce osteoporosis and bone fractures. In this study, we evaluate the effects of oral alendronate and alfacalcidol, or alfacalcidol alone on the bone of Chinese patients with MG who will initiate treatment with GCs. Read More

    Clinical features and autoimmune associations in patients presenting with Idiopathic Isolated ACTH deficiency.
    Clin Endocrinol (Oxf) 2018 Mar 21;88(3):491-497. Epub 2018 Jan 21.
    Department of Endocrinology and Diabetes, Beaumont Hospital, Dublin, Ireland.
    Objective: Idiopathic Isolated ATCH deficiency (IIAD) is a rare cause of secondary adrenal insufficiency. As the condition is rare, and the diagnostic criteria ill-defined, there are few good clinical descriptions in the literature. We have described presenting features, autoimmune associations, natural history and responses to CRF, in a large case series of patients presenting with IIAD. Read More

    Pathogenic copy number variants in patients with congenital hypopituitarism associated with complex phenotypes.
    Clin Endocrinol (Oxf) 2018 Mar 10;88(3):425-431. Epub 2018 Jan 10.
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brasil.
    Objectives: The aetiology of congenital hypopituitarism (CH) is unknown in most patients. Rare copy number variants (CNVs) have been implicated as the cause of genetic syndromes with previously unknown aetiology. Our aim was to study the presence of CNVs and their pathogenicity in patients with idiopathic CH associated with complex phenotypes. Read More

    Progestin-primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial.
    Clin Endocrinol (Oxf) 2018 Mar 4;88(3):442-452. Epub 2018 Jan 4.
    Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Huangpu District, Shanghai, China.
    Objective: To compare the endocrinological profiles, cycle characteristics and pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) with or without clomiphene citrate (CC) supplementation in normal ovulatory women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

    Design: Prospective randomized controlled study.

    Patient(s): A total of 320 infertile women undergoing IVF/ICSI. Read More

    High risk of hypogonadism in young male cancer survivors.
    Clin Endocrinol (Oxf) 2018 Mar 10;88(3):432-441. Epub 2018 Jan 10.
    Molecular Reproductive Medicine Unit, Department of Translational Medicine, Lund University, Malmö, Sweden.
    Objective: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long-term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given.

    Design: Case-control study. Read More

    Sex hormone-binding globulin is associated with androgen deficiency features independently of total testosterone.
    Clin Endocrinol (Oxf) 2017 Dec 13. Epub 2017 Dec 13.
    Sexual Medicine and Andrology Unit, Department of Experimental Clinical and Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
    Objective: It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone-binding globulin (SHBG) is altered. However, in humans, evidence supporting the existence of a hypogonadism due to low T bioactivity is scanty. The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen-dependent parameters. Read More

    Relationships of serum 25-hydroxyvitamin D, ionized calcium and parathyroid hormone after obesity surgery.
    Clin Endocrinol (Oxf) 2018 Mar 4;88(3):372-379. Epub 2018 Jan 4.
    Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
    Objective: The high prevalence of secondary hyperparathyroidism (SHPT) after obesity surgery is a concern for long-term bone health. Limited knowledge exists about optimal vitamin D and suppression of parathyroid hormone (PTH) after these procedures. The aim of this study was to investigate the prevalence of SHPT and its relation to vitamin D status. Read More

    Cardiac function in paediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency.
    Clin Endocrinol (Oxf) 2018 Mar 2;88(3):364-371. Epub 2018 Jan 2.
    Children's Heart Center, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands.
    Background: Hyperandrogenism and exogenous glucocorticoid excess may cause unfavourable changes in the cardiovascular risk profile of patients with congenital adrenal hyperplasia (CAH).

    Objective: To evaluate the cardiac function in paediatric patients with CAH.

    Patients And Methods: Twenty-seven paediatric patients with CAH, aged 8-16 years, were evaluated by physical examination, electrocardiogram (ECG), conventional echocardiography, tissue Doppler imaging and two-dimensional (2D) myocardial strain (rate) imaging. Read More

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