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    12745 results match your criteria Clinical endocrinology[Journal]

    1 OF 255

    Endocrinopathies with Use of Cancer Immunotherapies.
    Clin Endocrinol (Oxf) 2017 Sep 23. Epub 2017 Sep 23.
    Division of Endocrinology Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California.
    Background: Immunomodulatory therapies, including CTLA-4 and PD-1 inhibitors, provide a directed attack against cancer cells by preventing T cell deactivation. However, these drugs also prevent the down-regulation of auto-reactive T cells, resulting in immune-related adverse events (IRAEs). Reports show a varied incidence of endocrine IRAEs, ranging from 0-63%. Read More

    Autoantibodies against the calcium-sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3, and 4.
    Clin Endocrinol (Oxf) 2017 Sep 23. Epub 2017 Sep 23.
    Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.
    Objective: The frequency of autoimmunity against the parathyroid glands in patients with polyglandular autoimmunity that is not due to autoimmune polyendocrine syndrome type 1 (APS1) is unclear. To investigate this, the current study aimed to determine the prevalence of autoantibodies against parathyroid autoantigens the calcium-sensing receptor (CaSR) and NACHT leucine-rich-repeat protein 5 (NALP5) in a large group of patients with non-APS1 polyendocrine autoimmunity. Possible occult APS1 was investigated by cytokine autoantibody measurement and AIRE gene analysis. Read More

    Clinical Features and Prognosis of Thymic Neuroendocrine Tumors Associated with Multiple Endocrine Neoplasia Type 1: A Single Center Study, Systematic Review, and Meta-analysis.
    Clin Endocrinol (Oxf) 2017 Sep 20. Epub 2017 Sep 20.
    Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P.R.China.
    Objective: Thymic neuroendocrine tumor (TH-NET) accounts for almost 20% of multiple endocrine neoplasia type 1 (MEN1)-associated mortality. Identifying risk factors for the development of these rare tumors and prognostic factors for clinical outcomes will be helpful in clinical practice.

    Design And Patients: We performed a retrospective analysis of patients treated for TH-NET associated with MEN1 in a single institution and meta-analysis of literature reports. Read More

    The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2017 Sep 20. Epub 2017 Sep 20.
    Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background And Objective: Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder associated with metabolic syndrome (MetS). The aim of this systematic review and meta-analysis was to provide the most reliable estimate risk of MetS in women with PCOS, compared to healthy controls.

    Methods: A comprehensive literature search was performed in PubMed [including Medline], Web of Science and Scopus databases for retrieving articles in English language on the prevalence/incidence and odds of MetS in women with PCOS compared to healthy controls. Read More

    Factitious ACTH- dependent, apparent hypercortisolism: the problem with late night salivary cortisol measurements collected at home.
    Clin Endocrinol (Oxf) 2017 Sep 20. Epub 2017 Sep 20.
    Section of Clinical Biochemistry, Calgary Laboratory Services, Calgary, AB, Canada.
    Cushing's Syndrome (CS) is critical to identify because of the numerous and sometimes irreversible sequelae. Surreptitious glucocorticoid use is usually a straightforward consideration in the Cushingoid patient having suppressed ACTH levels, in the absence of adrenal mass or hyperplasia, and in whom screening tests for CS have unexpectedly low or high results depending on the specific steroid used and vulnerability of the assay employed to analytical cross-reactivity. We present a case of a patient with factitious hypercortisolism without suppressed ACTH. Read More

    Primary hyperparathyroidism: Dynamic postoperative metabolic changes.
    Clin Endocrinol (Oxf) 2017 Sep 14. Epub 2017 Sep 14.
    Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Austria.
    Objective: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated.

    Design: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intraoperatively, at post-operative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6. Read More

    Influence of coexistent Hashimoto's thyroiditis on the extent of cervical lymph node dissection and prognosis in papillary thyroid carcinoma.
    Clin Endocrinol (Oxf) 2017 Sep 14. Epub 2017 Sep 14.
    Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objective: Previous studies did not focus on the differences in the extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) in patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed to determine whether extensive cervical LN dissection is responsible for favorable clinical outcomes in PTC patients with HT and whether coexistence of HT itself has an independent protective effect regardless of LN status.

    Design: Retrospective cohort study PATIENTS: 1,369 patients with PTC who underwent total thyroidectomy with central compartment neck dissection. Read More

    Prevention of total thyroidectomy in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) based on combined interpretation of ultrasonographic and cytopathologic results.
    Clin Endocrinol (Oxf) 2017 Sep 12. Epub 2017 Sep 12.
    Department of Radiology, 1 Seoul National University College of Medicine, Seoul, Korea.
    Objective: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer.

    Patients: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11. Read More

    Letter to Liu et al 2017 Article.
    Clin Endocrinol (Oxf) 2017 Sep 12. Epub 2017 Sep 12.
    Penn State College of Medicine, Hershey, PA, USA.
    I was intrigued to see the recent trial of Liu et al(1) reporting the benefits of exenatide over metformin in terms of weight loss and pregnancy rate in women with polycystic ovary syndrome. I am writing to clarify the discrepancies between the trial as registered and the trial as reported in the manuscript. According to the trial registration on the Chinese Clinical Trial Registration Site (ChiCTR-IIR-16008084) the trial was a three armed trial for exenatide, metformin, or spironolactone. Read More

    Thyroid-stimulating hormone and risk of sudden cardiac death, total mortality and cardiovascular morbidity.
    Clin Endocrinol (Oxf) 2017 Sep 1. Epub 2017 Sep 1.
    Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
    Background: Previous data on the association of thyroid function with total mortality, cardiovascular disease (CVD) outcomes and sudden cardiac death (SCD) are conflicting or limited. We investigated associations of thyroid-stimulating hormone (TSH) with these outcomes in a nationwide population-based prospective cohort study.

    Methods: We examined 5211 participants representative of the Finnish population aged ≥30 years in 2000-2001 and followed them for a median of 13. Read More

    Genetics of Cushing's disease.
    Clin Endocrinol (Oxf) 2017 Aug 29. Epub 2017 Aug 29.
    Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany.
    Cushing's disease (CD) is a rare disabling condition caused by Adrenocorticotropic hormone (ACTH)-secreting adenomas of the pituitary. The majority of corticotropic adenomas are monoclonal and occur sporadically. Only rarely does CD arise in the context of genetic familial syndromes. Read More

    The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study.
    Clin Endocrinol (Oxf) 2017 Aug 29. Epub 2017 Aug 29.
    Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Objective: Data on the association between subclinical thyroid dysfunction and dementia are limited and conflicting. We aimed to determine whether subclinical thyroid dysfunction was associated with dementia and cognitive decline.

    Design: Population-based prospective cohort study. Read More

    Bone markers in polycystic ovary syndrome: A multicentre study.
    Clin Endocrinol (Oxf) 2017 Aug 28. Epub 2017 Aug 28.
    Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital and University of Oulu, Oulu, Finland.
    Objective: Hyperandrogenism, hyperinsulinaemia and obesity, known characteristics of polycystic ovary syndrome (PCOS), may influence bone mineral density and biochemical markers of bone turnover (BTMs) can provide a noninvasive assessment of bone turnover. To this end, the serum concentrations of BTMs and 25-hydroxyvitamin D (25OHD) were analysed in women with PCOS, and their possible associations with metabolic parameters of PCOS were determined.

    Subjects And Methods: Bone formation markers procollagen type I amino-terminal propeptide (PINP) and osteocalcin (OC), and bone resorption marker carboxy-terminal cross-linking telopeptide of type I collagen (CTX), along with 25OHD, were measured in 298 women with PCOS and 194 healthy controls. Read More


    Efficacy of exenatide on weight loss, metabolic parameters and pregnancy in overweight/obese polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Aug 23. Epub 2017 Aug 23.
    Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
    Context: Weight loss remains one of the most important arms in obese patients with polycystic ovary syndrome (PCOS). Further studies are needed to identify the best treatment.

    Objective: To evaluate the effects of exenatide (EXE) on reproductive and metabolic function in overweight/obese (OW/OB) PCOS. Read More

    Primary hyperparathyroidism in Chinese children and adolescents: A single-centre experience at Peking Union Medical College Hospital.
    Clin Endocrinol (Oxf) 2017 Aug 22. Epub 2017 Aug 22.
    Key laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
    Objective: Primary hyperparathyroidism (PHPT) in children is thought to be extremely rare. Our study aimed to summarize the clinical characteristics and the molecular genetics in patients with paediatric PHPT in China.

    Design: Retrospective observational study. Read More

    Clinical and genetic features of 64 young male paediatric patients with congenital hypogonadotropic hypogonadism.
    Clin Endocrinol (Oxf) 2017 Aug 20. Epub 2017 Aug 20.
    National Center for Children's Health, Capital Medical University, Beijing, China.
    Context: The diagnosis of congenital hypogonadotropic hypogonadism (CHH) in prepuberty has always been challenging. Here, we aimed at studying the clinical and genetic features of paediatric CHH, especially the phenotype of hypospadias and dual defects (patients showing hypothalamic and/or pituitary defects and testicular hypoplasia), so as to have a better understanding of CHH.

    Design: The clinical and genetic features of patients with CHH were analysed, and the relationships between hypospadias, dual defects and genetics were investigated. Read More

    Iron metabolism in patients with Graves' hyperthyroidism.
    Clin Endocrinol (Oxf) 2017 Aug 18. Epub 2017 Aug 18.
    Division of Endocrinology and Diabetes, Luzerner Kantonsspital, Luzern, Switzerland.
    Objectives: Graves' hyperthyroidism (GH) interferes with iron metabolism and elevates ferritin. The precise mechanisms remain unclear. The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized. Read More

    Serum chemerin levels are inversely associated with renal function in a general population.
    Clin Endocrinol (Oxf) 2017 Aug 18. Epub 2017 Aug 18.
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
    Objective: Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans, and no population-based analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. Read More

    Diagnostic performance of unenhanced computed tomography and (18) F-fluorodeoxyglucose positron emission tomography in indeterminate adrenal tumours.
    Clin Endocrinol (Oxf) 2017 Aug 17. Epub 2017 Aug 17.
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
    Objective: Evidence on the diagnostic performance of adrenal imaging is limited. We aimed to assess the diagnostic performance of unenhanced computed tomography (CT) and (18) F-fluorodeoxyglucose ((18) FDG) positron emission tomography (PET)/CT imaging in a high-risk population for adrenal malignancy using an optimal reference standard.

    Design: Retrospective cohort study. Read More

    Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency.
    Clin Endocrinol (Oxf) 2017 Aug 16. Epub 2017 Aug 16.
    Charité Universitätsmedizin Berlin, Berlin, Germany.
    Objectives: There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort(®) , an immediate-release, granule formulation of hydrocortisone with taste masking.

    Study Design: Single site with satellites attended by a "flying" doctor from investigator site. Read More

    Corticotrophin-releasing hormone stimulation tests for the infants with relative adrenal insufficiency.
    Clin Endocrinol (Oxf) 2017 Aug 12. Epub 2017 Aug 12.
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background: Very low birthweight (VLBW) infants are considered to be vulnerable to relative adrenal insufficiency (RAI); however, diagnosis is difficult in some clinical settings. Considering this background, it is necessary to establish a diagnosis of RAI in preterm infants.

    Objective: In this study, we attempted to clarify the difference in response to CRH stimulation tests for preterm infants with or without RAI. Read More

    Neurokinin 3 receptor antagonism decreases gonadotropin and testosterone secretion in healthy men.
    Clin Endocrinol (Oxf) 2017 Aug 12. Epub 2017 Aug 12.
    MRC Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
    Objective: Patients with mutations of neurokinin B (NKB) and its receptor show hypogonadotrophic hypogonadism, but there is little evidence for the importance of this pathway in reproductive function in normal men, or its functional hierarchy with kisspeptin.

    Design: An open label study wherein men (n = 6) were administered the NK3R antagonist MLE4901 40 mg orally twice a day for 7 days. Kisspeptin-10 (0. Read More

    Dipeptidyl peptidase 4 serum activity and concentration are increased in women with polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Aug 11. Epub 2017 Aug 11.
    Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Halle, Germany.
    Objective: Polycystic ovary syndrome (PCOS) is a complex disease, the aetiology of which is not well understood. Alterations in potential candidate genes involved in the biosynthesis and metabolism of androgens, folliculogenesis and insulin and glucose metabolism have been suggested as possible aetiologies. Dipeptidyl peptidase-4 (DPP4) plays a key role in glucose homoeostasis and, thus, in the regulation of insulin secretion. Read More

    Area under the curve during OGTT in first-degree relatives of diabetic patients as an efficient indicator of future risk of type 2 diabetes and prediabetes.
    Clin Endocrinol (Oxf) 2017 Aug 9. Epub 2017 Aug 9.
    Isfahan Endocrine & metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: To establish whether the area under the curve of an OGTT has a predictive role in identifying prediabetic and diabetic subjects among first-degree relatives (FDR) of patients with diabetes mellitus type 2 (DM).

    Design, Patients And Measurements: In a population-based cohort study, 766 FDR of diabetic patients with a normal glucose tolerance test (NGT) completed a 2-hour OGTT. They were followed up for 7 years and classified according to the American Diabetes Association criteria into: NGT, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and DM. Read More

    Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism.
    Clin Endocrinol (Oxf) 2017 Aug 8. Epub 2017 Aug 8.
    Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
    Objective: Correct subtyping of primary aldosteronism (PA) is essential for good surgical outcomes. Adrenal vein sampling (AVS) and/or computed tomography (CT) are used for PA subclassification. Clinical and/or biochemical improvement after surgery, however, is not always achieved in patients with presumed unilateral PA. Read More

    Prevalence of treated hypothyroidism in the community: Analysis from general practices in North-East England with implications for the United Kingdom.
    Clin Endocrinol (Oxf) 2017 Aug 7. Epub 2017 Aug 7.
    Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK.
    Objective: Hypothyroidism is more frequently diagnosed in women and older individuals. It has been suggested that the prevalence of hypothyroidism and the number of prescriptions for thyroid hormones are increasing. However, despite hypothyroidism being a common medical condition, contemporary data on prevalence, particularly across the various age groups, is limited. Read More

    Cognitive impairment in adolescents and adults with congenital adrenal hyperplasia.
    Clin Endocrinol (Oxf) 2017 Aug 3. Epub 2017 Aug 3.
    Department of Women's and Children's Health, Pediatric Endocrinology Unit (Q2:08), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Objective: Impaired cognition has been reported in patients with congenital adrenal hyperplasia (CAH), although the findings have been conflicting. It has been hypothesized that the major causes of the deficits are prenatal hormonal imbalances and/or excessive glucocorticoid treatment.

    Design: An observational study investigating cognition in patients with CAH. Read More

    Redefining the stress cortisol response to surgery.
    Clin Endocrinol (Oxf) 2017 Jul 31. Epub 2017 Jul 31.
    Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
    Background: Cortisol levels rise with the physiological stress of surgery. Previous studies have used older, less-specific assays, have not differentiated by severity or only studied procedures of a defined type. The aim of this study was to examine this phenomenon in surgeries of varying severity using a widely used cortisol immunoassay. Read More

    A distinct serum metabolic signature of distant metastatic papillary thyroid carcinoma.
    Clin Endocrinol (Oxf) 2017 Jul 29. Epub 2017 Jul 29.
    Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
    Background: Although the incidence rate for thyroid cancer seems to have begun stabilizing in recent years, an increased rate of advanced stage of this disease has been reported. Additionally, distant metastasis is one of the most important prognostic factors of patients with papillary thyroid carcinoma (PTC). Unfortunately, the underlying mechanisms of distant metastasis as well as cell status like metabolism changes in distant metastatic tumors have not been clearly elucidated. Read More

    Raising awareness of Graves' orbitopathy with early warning cards.
    Clin Endocrinol (Oxf) 2017 Jul 29. Epub 2017 Jul 29.
    Thyroid Research Group, Cardiff University School of Medicine, Cardiff, UK.
    Background: Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and establishing a fast-track referral pathway to specialist care should overcome these delays and potentially improve outcomes. Read More

    Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.
    Clin Endocrinol (Oxf) 2017 Jul 27. Epub 2017 Jul 27.
    Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
    Objective: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC).

    Aim: To investigate whether the endometrium of women with PCOS possesses gene expression changes similar to those found in EC.

    Design And Methods: Patients with EC, PCOS and control women unaffected by either PCOS or EC were recruited into a cross-sectional study at the Nottingham University Hospital, UK. Read More

    Thyroid disease symptoms during early pregnancy do not identify women with thyroid hypofunction that should be treated.
    Clin Endocrinol (Oxf) 2017 Jul 26. Epub 2017 Jul 26.
    University of Illinois College of Medicine, Rockford, IL, USA.
    Objective: To evaluate whether women during early pregnancy with "hypothyroidism" symptoms are at risk of biochemically defined hypothyroidism. The 2017 Guidelines of the American Thyroid Association (ATA) recommend case-finding on the basis of symptoms to identify these women during pregnancy, while evidence is lacking.

    Design: Construct validation of a thyroid hypofunction symptom checklist during the first trimester of pregnancy comparing high scores with biochemically defined hypothyroidism. Read More

    Serum glypican 4 level in obese children and its relation to degree of obesity.
    Clin Endocrinol (Oxf) 2017 Jul 26. Epub 2017 Jul 26.
    Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Objective: Previous adult studies have demonstrated associations of serum glypican 4 (Gpc4) and obesity parameters and insulin sensitivity. However, an association of serum Gpc4 and glucose metabolism remains contradictory. Study of serum Gpc4 in obese children has not been conducted. Read More

    The author's reply "Ultrasonography and cytology as predictors of noninvasive follicular thyroid (NIFTP) neoplasm with papillary-like nuclear features: importance of the differential diagnosis with the invasive encapsulated follicular variant of papillary thyroid cancer".
    Clin Endocrinol (Oxf) 2017 Jul 26. Epub 2017 Jul 26.
    Department of Radiology and Center for Imaging Science, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

    Outcomes of patients with metastatic phaeochromocytoma and paraganglioma: A systematic review and meta-analysis.
    Clin Endocrinol (Oxf) 2017 Jul 26. Epub 2017 Jul 26.
    Division of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, MN, USA.
    Objective: The outcomes of patients with metastatic phaeochromocytoma (PHEO) and paraganglioma (PGL) are unclear. We performed a systematic review and meta-analysis of baseline characteristics and mortality rates of patients with metastatic PHEO and PGL (PPGL).

    Design: Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Scopus, Web of Science, and references of key articles were searched from inception to 2016. Read More

    Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations.
    Clin Endocrinol (Oxf) 2017 Jul 22. Epub 2017 Jul 22.
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.
    Background: Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP).

    Objective: To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian).

    Design And Methods: We studied 23 index patients with CPHD and OPP (six familial and 17 sporadic) as well as 14 relatives. Read More

    Pregnancy in women with nonclassic congenital adrenal hyperplasia: Time to conceive and outcome.
    Clin Endocrinol (Oxf) 2017 Jul 21. Epub 2017 Jul 21.
    Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Objective: Nonclassic congenital adrenal hyperplasia (NCAH) is common among Ashkenazi Jews (1:400). It is associated with various degrees of postnatal virilization, irregular menses and infertility. Therapy of symptomatic subjects consists of physiologic doses of glucocorticoids. Read More

    Nulliparity is associated with subtle adverse metabolic outcomes in overweight/obese mothers and their offspring.
    Clin Endocrinol (Oxf) 2017 Jul 20. Epub 2017 Jul 20.
    Liggins Institute, University of Auckland, Auckland, New Zealand.
    Background: We aimed to evaluate metabolic outcomes in overweight/obese nulliparous and multiparous women and their offspring.

    Study Design: Seventy-two overweight and obese women who participated in a randomized controlled trial of exercise in pregnancy were included in the study, comparing 18 nulliparous and 54 multiparous women and their singleton offspring. Women were assessed at 19 and 36 weeks of gestation. Read More

    Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control.
    Clin Endocrinol (Oxf) 2017 Jul 20. Epub 2017 Jul 20.
    Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institute, Stockholm, Sweden.
    Objective: Polycystic ovary syndrome (PCOS) is commonly affected by obesity. PCOS phenotypes are prone to increased waist/hip ratio, insulin resistance and dyslipidaemia. This substudy was undertaken to evaluate the effects of lifestyle interventions on metabolic biomarkers in overweight/obese PCOS women and the interventional effects of dietary components related to metabolic outcomes. Read More

    Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism. A nationwide Danish register-based study.
    Clin Endocrinol (Oxf) 2017 Jul 20. Epub 2017 Jul 20.
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark.
    Background: The triggering of thyroid autoimmunity in the genetically susceptible remains a conundrum. Environmental exposures during gestation and/or early postnatally have proponents, as suggested in diabetes mellitus, with a higher incidence of births during spring and summer. Whether the development of autoimmune hypothyroidism (AIT) is influenced by month or season of birth is less clear. Read More

    Response to therapy of papillary thyroid cancer of known BRAF status.
    Clin Endocrinol (Oxf) 2017 Jul 18. Epub 2017 Jul 18.
    The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland.
    Objective: A dynamic risk stratification with modified initial estimated risk based on response to therapy and disease course is one of the crucial changes adopted recently by the American Thyroid Association (ATA). This approach focuses on an individualized risk-adapted approach to the management of differentiated thyroid cancer. The BRAF V600E mutation is the most common genetic alteration in papillary thyroid cancer (PTC). Read More

    Radiofrequency ablation for the management of thyroid nodules: A critical appraisal of the literature.
    Clin Endocrinol (Oxf) 2017 Jul 18. Epub 2017 Jul 18.
    Department of Diagnostic Imaging and Interventional Radiology, Regina Apostolorum Hospital, Albano Laziale, Rome, Italy.
    The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has changed the natural history of benign, enlarging thyroid nodules (TNs). Read More

    The effect of routine radiological reporting of thyroid incidentalomas on rates of thyroid needle biopsy, thyroid surgery and detection of thyroid malignancy.
    Clin Endocrinol (Oxf) 2017 Jul 18. Epub 2017 Jul 18.
    Department of Radiology, Eastbourne District General Hospital, Eastbourne, UK.
    Objective: This study looked at the effect of a changing radiology reporting policy to routinely review the thyroid gland where visible and report on any thyroid lesion, recommending further investigation as appropriate.

    Context: Incidentaloma is a term used to describe a lesion found on imaging unrelated to the clinical issue under investigation. There is variability in the radiological reporting of thyroid incidentalomas and conflicting recommendations as to how these lesions should be managed. Read More

    The application of serum iodine in assessing individual iodine status.
    Clin Endocrinol (Oxf) 2017 Jul 14. Epub 2017 Jul 14.
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.
    Context: The prevalence of thyroid disease in China is on the rise, and this could be partly associated with excessive iodine intake in some individuals; therefore, increased attention is being paid to individual iodine status. However, current indices are not appropriate for evaluating individual iodine status.

    Objective: To evaluate the association between serum iodine and urinary iodine (UI), as well as thyroid diseases, and provide an excellent base for future individual iodine status assessment. Read More

    A novel variant of DHH in a familial case of 46,XY disorder of sex development: Insights from molecular dynamics simulations.
    Clin Endocrinol (Oxf) 2017 Jul 14. Epub 2017 Jul 14.
    Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
    Objective: Disorders of sex development (DSD) are a heterogeneous group of conditions affecting the differentiation and development of the internal and external genitalia. Here, we aimed at identifying the genetic cause of DSD in two 46,XY sisters from a consanguineous family.

    Design: We performed a whole-exome sequencing of two 46,XY female individuals. Read More

    Long-term health outcomes of adults with McCune-Albright syndrome.
    Clin Endocrinol (Oxf) 2017 Jul 12. Epub 2017 Jul 12.
    Department of Endocrinology, The Royal Children's Hospital, Melbourne, VIC, Australia.
    Context: McCune-Albright syndrome (MAS) is associated with numerous health problems. Comprehensive long-term health problems of adults with MAS are less well defined in the literature.

    Objective: Our objective is to report comprehensive health outcomes of adults with MAS (>18 years). Read More

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