12,919 results match your criteria Clinical endocrinology[Journal]


Children with MEN1 gene mutations may present first (and at a young age) with Cushing disease.

Clin Endocrinol (Oxf) 2018 Jun 21. Epub 2018 Jun 21.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, 20892.

Objective: Cushing disease (CD) is a rare entity caused by ACTH-secreting pituitary tumors, leading to prolonged hypercortisolism. Most cases are sporadic but can rarely occur in the context of familial predisposition, due to germline mutations in genes such as MEN1, leading to multiple endocrine neoplasia type 1, MEN1. We have reported previously that CD can be the first and only presenting manifestation of MEN1. Read More

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Statin Medications and the Risk of Gynecomastia.

Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.

Department of Ophthalmology and Visual Sciences and Pharmacology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Objective: Case reports have suggested an increased risk of gynecomastia with HMG-CoA reductase inhibitors (i.e. statins). Read More

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Small for gestational age is a risk factor for the development of delayed thyrotropin elevation in infants weighing less than 2000 g.

Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.

Department of Neonatal Medicine, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan.

Objective: Delayed thyrotropin (TSH) elevation (dTSHe) is common in low birthweight infants. We aimed to clarify the risk factors for the development of dTSHe in infants weighing <2000 g at birth.

Patients And Methods: According to Japanese guidelines, infants with birthweight <2000 g underwent second capillary TSH screening within 30 days, either at one month of age; or when weight reached 2. Read More

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Should survivors of childhood cancer or testicular cancer be screened for androgen deficiency?

Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.

Department of Medicine, University of Washington, Seattle, Washington, USA.

Many neoplastic diseases that are common in childhood, adolescence and early adulthood were previously uniformly and swiftly fatal. These neoplastic diseases and their therapies are associated with an increased incidence of multiple endocrinopathies. For example, intracranial neoplasias invade the hypothalamus and/or pituitary and cause deficiencies of growth hormone, gonadotropins, thyrotropin or adrenocorticotropin. Read More

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Long-term follow up of a large prospective cohort of patients with non-functioning pituitary adenomas: the outcome of a conservative management policy.

Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.

Department of Diabetes & Endocrinology University Hospitals of Leicester NHS Trust Leicester Royal Infirmary Leicester LE1 5WW.

Objective: To assess the clinical outcome of a strategy of conservative monitoring of patients with non-functioning pituitary adenomas (NFPA) after pituitary surgery and in patients without surgery.

Design: Retrospective study of outcomes, using a clinical information system.

Patients: An unselected, clinical series of patients seen in a single centre between 1989 and 2015. Read More

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Hyponatremia, falls and bone fractures: a systematic review and meta-analysis.

Clin Endocrinol (Oxf) 2018 Jun 19. Epub 2018 Jun 19.

Endocrine Unit ", University of Florence, Florence, Italy.

Objective: To perform a meta-analysis based on published studies that compared falls and bone fractures between patients with and without hyponatremia.

Context: There is evidence suggesting that hyponatremia is associated with an increased risk of falls and bone fractures.

Design: An extensive Medline, Embase and Cochrane search was performed to retrieve all studies published up to, April 30 2017, using the following words: "hyponatremia" or "hyponatraemia" AND "falls" and "bone fractures". Read More

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June 2018
2 Reads

Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal.

Clin Endocrinol (Oxf) 2018 Jun 12. Epub 2018 Jun 12.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.

Objective: Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group.

Design/patients: Retrospective cohort study of women with prolactinoma diagnosed before menopause and who after menopause were not on DA. Read More

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Prevalence of Thyroid Dysfunction in a Large Southern European Population Analysis of modulatory factors The APNA Study.

Clin Endocrinol (Oxf) 2018 Jun 12. Epub 2018 Jun 12.

Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.

Context: To study the prevalence of thyroid dysfunction in a very large unselected population.

Objective: To determine the prevalence of abnormal thyroid function and evaluate potential modulatory factors.

Design And Setting: The Estudio de Atención Primaria de Navarra, The APNA Study, is a cross-sectional study conducted in northern Spain. Read More

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Changes over time in hip fracture risk: greater improvements in men compared to women.

Clin Endocrinol (Oxf) 2018 Jun 9. Epub 2018 Jun 9.

Department of Endocrinology, John Hunter Hospital, Newcastle, New South Wales, Australia.

Purpose: The aim of this study was to determine whether there has been a change in the mean age and age-standardised incidence of minimal trauma hip fractures in the Newcastle and Lake Macquarie population of Australia between 1998 and 2015.

Method: Patients with neck of femur fractures over 50 who presented to the regional referral centre were retrospectively identified using the ICD-9 and ICD-10 coding system.

Results: There were 233 and 308 eligible patients in 1998 and 2015 respectively. Read More

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The association between liver cirrhosis and fracture risk: a systematic review and meta-analysis.

Clin Endocrinol (Oxf) 2018 Jun 9. Epub 2018 Jun 9.

Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China.

Objective: Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic review and meta-analysis aims to explore the association between LC and fracture risk.

Design: To identify related literature, a systematic search of PubMed, EMBASE, Web of science, and the Cochrane Library from 1965 to July 2017 without language limitation was performed. Read More

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Fracture risk in young and middle-aged adults with Type 1 diabetes mellitus: a systematic review and meta-analysis.

Clin Endocrinol (Oxf) 2018 Jun 7. Epub 2018 Jun 7.

Department of Endocrinology, Monash Health, Clayton, Australia.

Background: Type 1 diabetes mellitus (T1DM) is associated with skeletal fragility. While previous meta-analyses have demonstrated an increased risk of fracture in individuals with T1DM, little is known about fracture risk in T1DM, in the absence of age-related confounders.

Aims: To determine the risk of fracture in young and middle-aged adults with T1DM aged 18 to 50 years old. Read More

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Extreme phenotypic variability of a novel GLI2 mutation in a large family with panhypopituitarism and polydactyly; clinical implications.

Clin Endocrinol (Oxf) 2018 Jun 7. Epub 2018 Jun 7.

Department of Clinical Genetics, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Congenital panhypopituitarism refers to the deficiency of two or more pituitary hormones in the newborn. It is a rare condition of which early recognition is of great importance because of its life threatening potential and its deleterious effects on growth and development. The aetiology remains unsolved in 80-90% of cases. Read More

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Prolonged HCG therapy for inguinal testis is effective for testicular descent in prepubertal males presenting after age 10 years.

Clin Endocrinol (Oxf) 2018 Jun 7. Epub 2018 Jun 7.

Department of Endocrinology, Dr. RML Hospital, Delhi.

We recently came across an interesting article by Dixon et al entitled "Prolonged human chorionic gonadotrophin stimulation as a tool for investigating and managing undescended testes" published in 2007 in your journal(1). The authors showed that around 30% of cryptorchid males had peak rise in testosterone at day 22 after a prolonged HCG stimulation for 2 weeks. While there are no set protocols, HCG therapy for undescended testes (UDT)in varying doses is usually given for a period of 2-6 weeks. Read More

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Characterization of cyclic cushing's disease using late night salivary cortisol testing.

Clin Endocrinol (Oxf) 2018 Jun 6. Epub 2018 Jun 6.

Neuroendocrine Unit and Neuroendocrine and Pituitary Tumor Clinical Center, Boston, MA.

Objective: To characterize a cohort of patients with cyclic Cushing's disease (CD) in comparison with non-cyclic CD using late night salivary cortisol (LNSC) and examine the diagnostic sensitivity of LNSC in comparison with that of 24 hour urine free cortisol (UFC) in this population.

Design: Retrospective study of patients with CD seen in our institution between 2008-2017 PATIENTS: 205 patients, including 17 (8%) with cyclic CD (based on a minimum of 3 peaks and 2 troughs in cortisol levels). In a secondary analysis, 38 patients (19%) with cyclic CD were identified (based on a criterion of at least 2 peaks and 1 trough). Read More

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Saline suppression test parameters may predict bilateral subtypes of primary aldosteronism.

Clin Endocrinol (Oxf) 2018 Jun 6. Epub 2018 Jun 6.

Department of Endocrinology, Monash Health, Clayton, Victoria.

Background: The saline suppression test (SST) serves to confirm the diagnosis of primary aldosteronism (PA) while adrenal vein sampling (AVS) is used to determine whether the aldosterone hypersecretion is unilateral or bilateral. An accurate prediction of bilateral PA based on SST results could reduce the need for AVS.

Aim: We sought to identify SST parameters that reliably predict bilateral PA. Read More

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Symptomatic Androgen Deficiency Develops only When Both Total and Free Testosterone Decline in Obese Men Who may have Incident Biochemical Secondary Hypogonadism: Prospective Results from the EMAS.

Clin Endocrinol (Oxf) 2018 Jun 1. Epub 2018 Jun 1.

Andrology Research Unit, Division of Endocrinology, Diabetes& Gastroenterology, Domain of Cardiovascular, Metabolic and Nutritional Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Old St Mary's Building, The University of Manchester, Hathersage Road, Manchester, M13 9WL, UK.

Objective: Limited evidence supports the use of free testosterone (FT) for diagnosing hypogonadism when sex hormone binding globulin (SHBG) is altered. Low total testosterone (TT) is commonly encountered in obesity where SHBG is typically decreased. We aimed to assess the contribution of FT in improving the diagnosis of symptomatic secondary hypogonadism (SH), identified initially by low total testosterone (TT), and then further differentiated by normal FT (LNSH) or low FT (LLSH). Read More

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June 2018
2 Reads

Simplified 4-item criteria for polycystic ovary syndrome: A bridge too far?

Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.

Department of Obstetrics and Gynaecology, National University of Singapore, Singapore, Singapore.

Objectives: Although the Rotterdam 2003 polycystic ovarian syndrome (PCOS) diagnostic criteria is widely used, the need to consider multiple variables makes it unwieldy in clinical practice. We propose a simplified PCOS criteria wherein diagnosis is made if two of the following three items were present: (i) oligomenorrhoea, (ii) anti-mullerian hormone (AMH) above threshold and/or (iii) hyperandrogenism defined as either testosterone above threshold and/or the presence of hirsutism.

Design Setting And Participants: This prospective cross-sectional study consists of healthy women (n = 157) recruited at an annual hospital health screen for staff and volunteers from the university community, and a patient cohort (n = 174) comprising women referred for suspected PCOS. Read More

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May 2018
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Thyrotoxicosis after iodine fortification. A 21 year Danish population based study.

Clin Endocrinol (Oxf) 2018 May 31. Epub 2018 May 31.

Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Objective: Monitoring the influence of cautious iodine fortification (IF) on the incidence rate of overt thyrotoxicosis in Denmark with formerly frequent multinodular toxic goitre.

Design: A 21 year (1997-2017) prospective population-based study identified all new cases of overt biochemical thyrotoxicosis in two open cohorts: a Western cohort with moderate iodine deficiency (ID) and an Eastern cohort with mild ID (total n=533,969 by January 1 , 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas. Read More

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Where in the world? Latitude, longitude and season contribute to the complex co-ordinates determining cortisol levels.

Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.

Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

Objective: Cortisol is a critical stress hormone with circadian rhythms synchronized by light. There are seasonal differences in expression of pro-inflammatory genes and in some diseases moderated by glucocorticoids. As light changes with season and with latitude and longitude, we assessed changes in population cortisol associated with these parameters. Read More

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Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews.

Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic., Australia.

Background: Polycystic ovary syndrome (PCOS) affects up to 13% women and is associated with significant complications. The quality of evidence supporting the recommendations on treatment of nonreproductive outcomes in PCOS is unknown.

Objective: To summarize and appraise the methodological quality of systematic reviews and meta-analyses evaluating pharmacological and surgical treatments for nonreproductive outcomes in PCOS. Read More

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Mild subclinical hypothyroidism is associated with paediatric dyslipidaemia.

Clin Endocrinol (Oxf) 2018 May 30. Epub 2018 May 30.

Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.

Background: There is a lack of consensus on the cardiometabolic consequences of mild subclinical hypothyroidism (SCH) among children. The objective of the current study was to compare lipid profiles in children with mild SCH with those of euthyroid children.

Study Design: Retrospective medical record review. Read More

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Are pregnancy, parity, menstruation and breastfeeding risk factors for thyroid cancer? Results from the Korea National Health and Nutrition Examination Survey, 2010-2015.

Clin Endocrinol (Oxf) 2018 May 28. Epub 2018 May 28.

Division of Endocrinology, Department of Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Context: It is unclear whether reproductive factors such as pregnancy, parity, menstruation, and breastfeeding are risk factors for thyroid cancer. The aim of this study was to evaluate the association of reproductive factors with thyroid cancer risk.

Design/setting: Large-scale nation-wide cross-sectional data were analysed from representative samples from the Korea National Health and Nutrition Examination Survey V-VI (2010-2015). Read More

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A novel mutation in KHDRBS1 in a patient affected by primary ovarian insufficiency.

Clin Endocrinol (Oxf) 2018 May 28. Epub 2018 May 28.

Center for Research in Genetics and Genomics (CIGGUR), School of Medicine and Health Sciences, GENIUROS Research Group, Universidad del Rosario, Bogotá, Colombia.

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May 2018
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Outcomes of Bethesda categories III and IV thyroid nodules over 5 years and performance of the Afirma gene expression classifier: A single-institution study.

Clin Endocrinol (Oxf) 2018 May 23. Epub 2018 May 23.

Department of Pathology, University of Colorado School of Medicine, Aurora, CO, USA.

Objective: The second edition Bethesda System for Reporting Thyroid Cytology estimates 6%-18% malignancy rate of category III (B3) and 10%-40% for category IV (B4) nodules; however, reported malignancy rates have considerable variability among institutions. Use of molecular classifiers (including Afirma Gene Expression Classifier, GEC) can be utilized in management of thyroid nodules. Our objective was to analyse malignancy rates of B3 and B4 nodules and determine clinical outcomes of GEC Benign nodules. Read More

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Should all patients with adrenal insufficiency or a subgroup of patients with prediabetes be treated with dual-release hydrocortisone?

Authors:
Roberta Giordano

Clin Endocrinol (Oxf) 2018 May 23. Epub 2018 May 23.

Division of Endocrinology, Diabetology and Metabolism Department of Medical Sciences, and Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

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Prospective evaluation of Ga-DOTATATE PET/CT in limited disease neuroendocrine tumours and/or elevated serum neuroendocrine biomarkers.

Clin Endocrinol (Oxf) 2018 May 22. Epub 2018 May 22.

Department of Nuclear Medicine, La Timone & North University Hospital, Aix-Marseille University, Marseille, France.

Context: The Ga-labelled somatostatin analogues ( Ga-DOTA-SSAs) is becoming popular as an important diagnostic tool in neuroendocrine tumours as evidenced by a growing number of reports detailing institutional experience with various DOTA peptides. However, only few prospective studies have compared Ga-DOTA-SSAs and somatostatin receptor scintigraphy (SRS) in gastroenteropancreatic neuroendocrine tumours (GEP-NETs) and pulmonary neuroendocrine tumours.

Objective: The aim of our prospective study was to perform head-to-head comparison between Ga-DOTATATE PET/CT and standard imaging work-up (SI) that included multiphasic CT, liver MRI and SRS using single photon emission computed tomography. Read More

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May 2018
1 Read

Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score.

Clin Endocrinol (Oxf) 2018 May 21. Epub 2018 May 21.

Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, USN Haut Leveque, Bordeaux, France.

Objective: Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Read More

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Natural history of Rathke's cleft cysts: A retrospective analysis of a two centres experience.

Clin Endocrinol (Oxf) 2018 May 21. Epub 2018 May 21.

Department of Neurological Surgery, Stanford University Hospital, Stanford, CA, USA.

Objective: Rathke's cleft cyst (RCC) is a common sellar lesion which may cause visual impairment, hypopituitarism and headaches from mass effect. The natural history of these lesions is currently unclear. We investigated the natural history of RCCs and compared surgically treated patients with those treated conservatively. Read More

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The Authors' Reply: In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient.

Clin Endocrinol (Oxf) 2018 May 17. Epub 2018 May 17.

Division of Pediatric Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.

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Diagnostic approach to low-renin hypertension.

Clin Endocrinol (Oxf) 2018 May 14. Epub 2018 May 14.

Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.

Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanisms underlying the development of both essential and secondary hypertension has occurred. Approximatively 25% of the patients affected by arterial hypertension display low-renin levels, a definition that is largely arbitrary and depends on the investigated population and the specific characteristics of the assay. Read More

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Effects of oestradiol for luteal phase support in fresh embryo transfer cycles: A retrospective cohort study.

Clin Endocrinol (Oxf) 2018 May 12. Epub 2018 May 12.

Key Laboratory of Reproductive Genetics (Ministry of Education), and Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Objective: Any benefit of oestradiol supplementation with progesterone for luteal support after fresh embryo transfer in in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycles remains controversial. In this study, we further addressed this question in cycles using gonadotropin-releasing hormone (GnRH) agonist for ovarian stimulation.

Design: A retrospective cohort study in a tertiary teaching and research hospital. Read More

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May 2018
4 Reads

Sex-specific associations of insulin-like peptides in cord blood with size at birth.

Clin Endocrinol (Oxf) 2018 May 11. Epub 2018 May 11.

Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.

Objective: Insulin-like peptides (insulin, IGF-1, IGF-2) are essential regulators of foetal growth. We assessed the role of these peptides for birth size in a sex-specific manner.

Design: Cross-sectional cohort analysis. Read More

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Assessment and management of bone health in women with oestrogen receptor-positive breast cancer receiving endocrine therapy: Position statement of the Endocrine Society of Australia, the Australian and New Zealand Bone & Mineral Society, the Australasian Menopause Society and the Clinical Oncology Society of Australia.

Clin Endocrinol (Oxf) 2018 May 9. Epub 2018 May 9.

Department of Endocrinology, Monash Health, Clayton, Vic., Australia.

To formulate clinical consensus recommendations on bone health assessment and management of women with oestrogen receptor-positive early breast cancer receiving endocrine therapy, representatives appointed by relevant Australian Medical Societies used a systematic approach for adaptation of guidelines (ADAPTE) to derive an evidence-informed position statement addressing 5 key questions. Women receiving adjuvant aromatase inhibitors and the subset of premenopausal woman treated with tamoxifen have accelerated bone loss and increased fracture risk. Both bisphosphonates and denosumab prevent bone loss; additionally, denosumab has proven antifracture benefit. Read More

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Comparison of high intensity focused ultrasound and radioiodine for treating toxic thyroid nodules.

Clin Endocrinol (Oxf) 2018 May 9. Epub 2018 May 9.

Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Purpose: We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were also evaluated as secondary end-points.

Materials And Methods: Among patients ≥18 years old with TTN observed at our centre between January 1st, 2016 and December 31th, 2016 we prospectively enrolled 17 and 15 age and sex-matched patients treated with RAI and HIFU, respectively. Read More

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Role of DOTATATE-PET/CT in preoperative assessment of phaeochromocytoma and paragangliomas.

Clin Endocrinol (Oxf) 2018 May 9. Epub 2018 May 9.

Department of Endocrinology and Diabetes, Royal North Shore Hospital, St Leonards, NSW, Australia.

Context: Diagnosis of paragangliomas (PGL) and phaeochromocytomas (PC) can be challenging particularly if the tumour is small. Detection of metastatic disease is important for comprehensive management of malignant PC/PGL. Somatostatin receptor imaging (SRI) agents have high sensitivity for these tumours, particularly the DOTA family of radiopharmaceuticals labelled with Gallium. Read More

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May 2018
1 Read

Effects of treatment with an angiotensin 2 receptor blocker and/or vitamin D3 on parathyroid hormone and aldosterone: A randomized, placebo-controlled trial.

Clin Endocrinol (Oxf) 2018 May 7. Epub 2018 May 7.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: Emerging evidence supports a positive, bidirectional and clinical relevant interaction between parathyroid hormone (PTH) and the renin-angiotensin-aldosterone-system (RAAS). A beneficial effect of the widely used RAAS inhibitors might include a PTH-lowering effect, as high PTH levels may be harmful to cardiovascular health. We aimed to investigate whether PTH levels are lowered by short-term treatment with an angiotensin 2 receptor blocker (valsartan) independently of coadministration of vitamin D3. Read More

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Leptin and IGF-1 in relation to body composition and bone mineralization of preterm-born children from infancy to 8 years.

Clin Endocrinol (Oxf) 2018 Jul 17;89(1):76-84. Epub 2018 May 17.

Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.

Objective: Preterm birth has been associated with altered body composition, especially increased fat mass (FM) and decreased bone mineralization, and leptin and IGF-1 have been suggested to be involved in the regulation of both. We aimed to study the interplay between leptin, IGF-1, FM and bone mineralization measured in infancy and childhood of children born preterm.

Design: Observational study. Read More

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Renal complications of lipodystrophy: A closer look at the natural history of kidney disease.

Clin Endocrinol (Oxf) 2018 Jul 17;89(1):65-75. Epub 2018 May 17.

Division of Endocrinology and Metabolism, Brehm Center for Diabetes Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Objectives: Lipodystrophy syndromes are a group of heterogeneous disorders characterized by adipose tissue loss. Proteinuria is a remarkable finding in previous reports.

Study Design: In this multicentre study, prospective follow-up data were collected from 103 subjects with non-HIV-associated lipodystrophy registered in the Turkish Lipodystrophy Study Group database to study renal complications in treatment naïve patients with lipodystrophy. Read More

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July 2018
3 Reads

Preconception management of thyroid dysfunction.

Clin Endocrinol (Oxf) 2018 Apr 29. Epub 2018 Apr 29.

Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.

Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Read More

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In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient.

Clin Endocrinol (Oxf) 2018 Apr 27. Epub 2018 Apr 27.

Laboratory of Cell Biology, Ariel University, Ariel, Israel.

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Clinical associations of maternal thyroid function with foetal brain development: Epidemiological interpretation and overview of available evidence.

Clin Endocrinol (Oxf) 2018 Apr 24. Epub 2018 Apr 24.

Rotterdam Thyroid Center, Erasmus Medical Center, Rotterdam, The Netherlands.

Thyroid hormone is an important regulator of early brain development, particularly during early stages of gestation during which foetal thyroid hormone availability depends on the maternal transfer of thyroid hormones. There is a wide range of experimental studies showing that low maternal thyroid hormone availability is associated with suboptimal brain development parameters. While few clinical studies have shown that overt maternal hypothyroidism is associated with lower child IQ, the question whether more subclinical changes in maternal thyroid function could also lead to suboptimal foetal brain development. Read More

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Hypogonadism and male obesity: Focus on unresolved questions.

Authors:
Mathis Grossmann

Clin Endocrinol (Oxf) 2018 Jul 16;89(1):11-21. Epub 2018 May 16.

Department of Medicine Austin Health, University of Melbourne, Heidelberg, Vic, Australia.

Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. HPT axis suppression is likely mediated via pro-inflammatory cytokine and dysregulated leptin signalling and aggravated by associated comorbidities. Read More

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Mortality data from the European Adrenal Insufficiency Registry-Patient characterization and associations.

Clin Endocrinol (Oxf) 2018 Jul 22;89(1):30-35. Epub 2018 Apr 22.

Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK.

Objective: Mortality from primary and secondary adrenal insufficiency (AI; PAI and SAI, respectively) is 2-3-fold higher than in the general population. Mortality relates to cardiovascular disease, acute adrenal crisis (AC), cancer and infections; however, there has been little further characterization of patients who have died.

Design/methods: We analysed real-world data from 2034 patients (801 PAI, 1233 SAI) in the European Adrenal Insufficiency Registry (EU-AIR; NCT01661387). Read More

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Ghrelin as a potential molecular marker of adrenal carcinogenesis: In vivo and in vitro evidence.

Clin Endocrinol (Oxf) 2018 Jul 17;89(1):36-45. Epub 2018 May 17.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Context: Adrenal tumours belong to one of the most prevalent neoplasms. It is a heterogeneous group with different aetiology, clinical manifestation and prognosis. Its histopathologic diagnosis is difficult and identification of differentiation markers for tumorigenesis is extremely valuable for diagnosis. Read More

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Growth hormone-Insulin-like growth factor 1 axis hyperactivity on bone fibrous dysplasia in McCune-Albright Syndrome.

Clin Endocrinol (Oxf) 2018 Jul 17;89(1):56-64. Epub 2018 May 17.

Section on Skeletal Disorders and Mineral Homeostasis, NIDCR, NIH, Bethesda, MD, USA.

Context: In fibrous dysplasia (BFD), normal bone and bone marrow are replaced by fibro-osseous tissue, leading to fracture, deformity and pain. BFD may be isolated, or in association with cutaneous hyperpigmentation and/or hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). GH hypersecretion has been described in 10%-20% of MAS-BFD patients. Read More

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July 2018
1 Read

Unexpected adverse effect of metyrapone: A case report.

Clin Endocrinol (Oxf) 2018 Jul 16;89(1):112-113. Epub 2018 Nov 16.

Service d'Endocrinologie, Diabétologie, Maladies Métaboliques, CHU Dijon, Dijon, France.

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July 2018
2 Reads

Dynamic risk stratification system in post-lobectomy low-risk and intermediate-risk papillary thyroid carcinoma patients.

Clin Endocrinol (Oxf) 2018 Jul 15;89(1):100-109. Epub 2018 May 15.

Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Objective: The dynamic risk stratification (DRS) and its current definition of each response-to-therapy category in post-lobectomy papillary thyroid carcinoma (PTC) patients have not been well studied. This study aimed to validate the DRS system and to investigate useful thyroglobulin (Tg) or anti-Tg antibody (Ab)-related parameters in defining each response-to-therapy category.

Design: Retrospective observational study. Read More

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July 2018
1 Read

Young age is associated with increased rates of residual and recurrent paediatric differentiated thyroid carcinoma.

Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.

Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.

Objective: Differentiated thyroid carcinoma is rare in young children. There are conflicting data as to whether disease in this age group differs from that in adolescents and specifically, if it is more aggressive. Current practice guidelines do not differentiate treatment between these groups, but speculate that differences may exist. Read More

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April 2018
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Quality of life in patients with adrenal disease: A systematic review.

Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.

Centre for Endocrinology, Barts and the London School of Medicine & Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.

Background: Evaluating the patient with adrenal disease is challenging due to the lack of precise clinical and biochemical parameters for disease control. Quality of life (QOL) evaluation aims to measure the patient's subjective experience.

Objective: To describe how QOL is defined and measured in adrenal disease, critically appraise the use of QOL tools in published literature, discuss the implications of these findings and provide direction for further research in this field. Read More

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April 2018
1 Read