13,114 results match your criteria Clinical endocrinology[Journal]


Improving glucocorticoid replacement profiles in adrenal insufficiency.

Clin Endocrinol (Oxf) 2019 Apr 24. Epub 2019 Apr 24.

Department of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Commonwealth Building, London, UK.

There is an increased mortality associated with adrenal insufficiency despite glucocorticoid replacement therapy with a standardised mortality ratio greater than two. The cause of the increased mortality is yet to be definitively elucidated, but may be due to excess steroid exposure, or replacement regimens that are uncoupled from the normal physiological cortisol profile. Cortisol secretion follows an ultradian pattern which is not possible to reproduce using oral replacement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13999DOI Listing

Rituximab for treatment of refractory insulin autoimmune syndrome associated with non-Hodgkin B-cell lymphoma.

Clin Endocrinol (Oxf) 2019 Apr 22. Epub 2019 Apr 22.

Southern Adelaide Diabetes and Endocrine Services, Marion, AUSTRALIA.

Insulin autoimmune syndrome (IAS or Hirata's Disease) is a rare cause of spontaneous hypoglycaemia. In IAS circulating autoantibodies bind endogenous insulin rendering insulin inactive. These complexes later dissociate in an unregulated manner resulting in hypoglycaemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13998DOI Listing

Different routes and formulations of melatonin in critically-ill patients. A pharmacokinetic randomized study.

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy.

Background And Objectives: Critically-ill patients present reduced endogenous melatonin blood levels, and they might benefit from its exogenous supplementation. The aim of this research was to evaluate the feasibility of different routes of administration and drug formulations of melatonin. The efficiency of absorption was assessed as well as the adequacy in achieving and maintaining the physiological nocturnal blood peak. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13993
Publisher Site
http://dx.doi.org/10.1111/cen.13993DOI Listing
April 2019
1 Read

Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with DSD (differences in sex development).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Elizabeth Garrett Anderson UCL Institute of Women's Health, University College London Hospitals, 250 Euston Road, London, NW12PG.

Discordance between gonadal type and gender identity has often led to an assumption of infertility in patients with differences in sex development (DSD). However, there is now greater recognition of fertility being an important issue for this group of patients. Currently, gonadal tissue that may have fertility potential is not being stored for individuals with DSD and, where gonadectomy forms part of management, is often discarded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13994DOI Listing

The values of shear wave elastography in avoiding repeat fine-needle aspiration for thyroid nodules with non-diagnostic and undetermined cytology.

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai, China.

Objective: To evaluate the value of shear wave elastography (SWE) in avoiding repeat fine-needle aspiration of thyroid nodules with non-diagnostic and undetermined cytology.

Methods: A total of 232 thyroid nodules with non-diagnostic (n=132) and undetermined (n=100) cytology underwent ultrasound (US) and SWE, followed by repeat ultrasound (US)-guided fine-needle aspiration cytology (FNAC). The final diagnosis was based on cytological or pathological findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13992DOI Listing

Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis (SIAD).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel, Switzerland.

Copeptin is secreted in an equimolar amount to arginine vasopressin (AVP) but can easily be measured in plasma or serum with a sandwich immunoassay. The main stimuli for copeptin are similar to AVP, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13991DOI Listing

A multicenter validation study for the EU-TIRADS using histological diagnosis as a gold standard.

Clin Endocrinol (Oxf) 2019 Apr 19. Epub 2019 Apr 19.

Thyroid Imaging and Cytopathology Centre, Paris, France.

Objective: Many systems for risk stratification of thyroid nodule with ultrasound (US) have been proposed and the EU-TIRADS issued by the ETA in 2017 was the last to have been published. The present study was undertaken to evaluate if the malignancy risk of each category corresponded to the given range of the guidelines and assess the diagnostic value of EU-TIRADS in a multi-institutional trial with histology as gold standard.

Design: Three institutions in Switzerland, France, and United Kingdom shared this retrospective study. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13997
Publisher Site
http://dx.doi.org/10.1111/cen.13997DOI Listing
April 2019
1 Read

Adrenal Morphology and Associated Comorbidities in Congenital Adrenal Hyperplasia.

Clin Endocrinol (Oxf) 2019 Apr 18. Epub 2019 Apr 18.

The National Institutes of Health Clinical Center, Bethesda, Maryland, 20892.

Objective: Adrenonodular hyperplasia and tumor formation are potential long-term complications of congenital adrenal hyperplasia (CAH) with little known regarding the clinical implications. Our aim was to describe volumetric adrenal morphology and determine the association between radiological findings and comorbidities in adults with classic CAH.

Design: This was a cross-sectional study of 88 patients (mean age 29. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13996
Publisher Site
http://dx.doi.org/10.1111/cen.13996DOI Listing
April 2019
1 Read
3.457 Impact Factor

Relationship between systolic hypertension assessed by 24-h ambulatory blood pressure monitoring and aortic diameters in young women with Turner syndrome.

Clin Endocrinol (Oxf) 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Objective: Patients with Turner syndrome (TS) are at high risk for cardiovascular morbidity and mortality due to aortic dilation. We evaluated the prevalence of hypertension and its risk factors, and investigated the relationship between systolic hypertension and aortic diameter in young TS patients.

Design: Observational, cross-sectional study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13995DOI Listing

Corrigendum.

Authors:

Clin Endocrinol (Oxf) 2019 May;90(5):769

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13957DOI Listing

Risk of incident circulatory disease in patients treated for differentiated thyroid carcinoma with no history of cardiovascular disease.

Clin Endocrinol (Oxf) 2019 Apr 16. Epub 2019 Apr 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, Edgbaston, United Kingdom, B15 2TT.

Context: The incidence of differentiated thyroid cancer (DTC) is increasing, yet the prognosis is favorable and long-term survival is expected. Exogenous TSH suppression has been used for many years to prevent DTC recurrence and may be associated with increased risks of circulatory diseases.

Design: Risks of circulatory disease in patients treated for DTC were compared to randomly matched patients without DTC (controls) up to a 1:5 ratio using age, sex, body mass index (BMI) and smoking as the matching parameters in a population-based, open cohort study using The Health Improvement Network. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13990DOI Listing
April 2019
1 Read

Prevalence of Growth Hormone Deficiency in previously GH-treated young adults with Prader-Willi syndrome.

Clin Endocrinol (Oxf) 2019 Apr 11. Epub 2019 Apr 11.

Dutch Growth Research Foundation, Rotterdam, The Netherlands.

Objective: Some features of subjects with Prader-Willi syndrome (PWS) resemble those seen in growth hormone deficiency (GHD). Children with PWS are treated with growth hormone (GH), which has substantially changed their phenotype. Currently, young adults with PWS must discontinue GH after attainment of adult height when they do not fulfill the criteria of adult GHD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13988DOI Listing
April 2019
1 Read

Independent relationships between bone mineral density, regional body fat and insulin sensitivity in white males.

Clin Endocrinol (Oxf) 2019 Apr 11. Epub 2019 Apr 11.

Diabetes, Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, London, UK.

Background: Adiposity and insulin sensitivity may affect bone mineral density (BMD), but the confounding effect of weight hinders discrimination of independent associations. We explored whether regional fat masses and insulin sensitivity are independently related to BMD.

Materials And Methods: Relationships between total and regional body fat, insulin sensitivity and measures of BMD in 8 different regions were evaluated in a cross section of 590 generally healthy, white males, 274 of whom received measurement of insulin sensitivity (Si) using the intravenous glucose tolerance test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13989DOI Listing
April 2019
1 Read

T-score differences and nonprogression in lumbar vertebrae as predictors of vertebral fractures.

Clin Endocrinol (Oxf) 2019 Apr 11. Epub 2019 Apr 11.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark.

Purpose: In case of a vertebral fracture, the area of the vertebrae decreases with a concomitant increase in BMD, as assessed by a DXA scanning. Furthermore, a vertebral fracture may disrupt the normal increase in vertebral body area from L1 to L4 (nonprogression). We aimed to examine associations between T-score difference and nonprogression of vertebral area and vertebral fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13987DOI Listing

Temporal increases in 25-hydroxyvitamin D in midlife women: Longitudinal results from the Study of Women's Health Across the Nation.

Clin Endocrinol (Oxf) 2019 Apr 10. Epub 2019 Apr 10.

Endocrine Unit, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

Objective: 25-hydroxyvitamin D (25(OH)D) is critical for bone mineralization and may prevent fractures. Understanding vitamin D deficiency trends in midlife women is particularly important given their concurrent menopausal changes that increase risk for fracture. We aimed to evaluate changes in mean 25(OH)D over time and their determinants in a racially, ethnically and socioeconomically diverse cohort of midlife women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13986DOI Listing
April 2019
1 Read

The use of Medical Identification Jewellery in Adults with Adrenal Insufficiency in Australia.

Clin Endocrinol (Oxf) 2019 Apr 9. Epub 2019 Apr 9.

Endocrine and Metabolic Unit, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia.

Objective: Hydrocortisone stress dosing during illness can prevent adrenal crises (AC) in patients with adrenal insufficiency (AI). When patients cannot communicate, medical identification jewellery may facilitate parenteral hydrocortisone provision but patient adoption rates are not known.

Design: A cross-sectional analysis of Australian medical identification jewellery subscription data. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13985
Publisher Site
http://dx.doi.org/10.1111/cen.13985DOI Listing
April 2019
4 Reads

Phenotypic diversity and glucocorticoid sensitivity in patients with familial partial lipodystrophy type 2.

Clin Endocrinol (Oxf) 2019 Apr 6. Epub 2019 Apr 6.

Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.

Familial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities and central obesity. Due to the resemblance with Cushing's syndrome, we hypothesized a putative role of glucocorticoid in the pathogenesis of metabolic abnormalities in FPLD2.

Objective: To evaluate the phenotypic heterogeneity and glucocorticoid sensitivity in FPLD2 patients exhibiting the p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13984DOI Listing

Blood pressure, sympathovagal tone, exercise capacity and metabolic status are linked in Turner syndrome.

Clin Endocrinol (Oxf) 2019 Apr 6. Epub 2019 Apr 6.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark.

Objectives: We studied cardiac autonomic changes in relation to metabolic factors, body composition and 24-hour ambulatory blood pressure measurements in Turner syndrome patients without known hypertension.

Design: Cross sectional.

Patients: Participants were 48 TS women and 24 healthy female controls aged over 18 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13983DOI Listing
April 2019
1 Read

Fertility desires and reproductive needs of transgender people: Challenges and considerations for clinical practice.

Clin Endocrinol (Oxf) 2019 Apr 3. Epub 2019 Apr 3.

Department of Endocrinology, Diabetology and Nutrition, University Hospital Centre Nancy, Vandoeuvre-lès-Nancy, France.

The majority of transgender and gender nonconforming persons seeking medical care are of reproductive age. Hormonal treatment and sex reassignment surgery, which are used in the management of gender dysphoria, compromise fertility potential. Children and adolescents with gender dysphoria have specific treatment regimens starting with puberty-blocking medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13982DOI Listing
April 2019
1 Read

Fibroblast growth factor 23 levels decline following sleeve gastrectomy.

Clin Endocrinol (Oxf) 2019 Apr 3. Epub 2019 Apr 3.

Faculty of Medical and Health Sciences, Department of Medicine, University of Auckland, Auckland, New Zealand.

Objective: Levels of fibroblast growth factor 23 (FGF23) have been positively associated with measures of adiposity, cardiovascular disease and mortality. It is unclear whether the relationship of FGF23 with cardiovascular disease and mortality is confounded by obesity. We aimed to determine whether FGF23 concentrations decline following a reduction in adiposity after sleeve gastrectomy (SG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13981DOI Listing
April 2019
3 Reads

Diffusion-weighted imaging (DWI) highlights SDHB-related tumours: A pilot study.

Clin Endocrinol (Oxf) 2019 Apr 1. Epub 2019 Apr 1.

Department of Endocrinology, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.

Objective: There is consensus that asymptomatic carriers of SDHB mutations should undergo periodic surveillance imaging. MRI has the advantage of avoiding radiation exposure but its sensitivity and specificity for detecting phaeochromocytoma and paraganglioma (PPGL) are dependent on sequences performed and expertise of reporting radiologists. We aim to highlight the additional value of diffusion-weighted imaging (DWI) for MR based surveillance, demonstrating DWI's ability to identify small PPGLs at all body sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13980DOI Listing
April 2019
2 Reads

Thyroid-stimulating hormone (TSH) serum levels and risk of spontaneous abortion: A prospective population-based cohort study.

Clin Endocrinol (Oxf) 2019 Mar 30. Epub 2019 Mar 30.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: Thyroid dysfunction, a common complication of pregnancy, is associated with adverse obstetric and neonatal consequences. This study aimed to determine the effect of TSH levels on early pregnancy outcome in a prospective population-based cohort study.

Design And Methods: The serum TSH, free thyroxine, free triiodothyronine, thyroid peroxidase antibody levels and urinary iodine concentration of 418 pregnant women in their first trimester of pregnancy were measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13979DOI Listing
March 2019
2 Reads

A prospective study on glucagon responses to oral glucose and mixed meal and 7-year change in fasting glucose.

Clin Endocrinol (Oxf) 2019 Mar 28. Epub 2019 Mar 28.

Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Introduction: The role of insufficient glucagon suppression after an oral load in the development of type 2 diabetes mellitus is unclear. The aim of this study was to examine the association between glucagon responses at baseline and fasting glucose levels 7 years later.

Methods: Data of the Hoorn Meal Study were used, an observational cohort study among 121 persons without diabetes with a mean age of 61. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13977
Publisher Site
http://dx.doi.org/10.1111/cen.13977DOI Listing
March 2019
3 Reads

Many women with Turner syndrome lack protective antibodies to common respiratory pathogens, Haemophilus influenzae type B and Streptococcus Pneumoniae.

Clin Endocrinol (Oxf) 2019 Mar 27. Epub 2019 Mar 27.

Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle Upon Tyne, UK.

Turner syndrome (TS) is a sex chromosomal disorder, affecting approximately 1 in 2,500 live-born females, and characterised by the absence of all or part of one X chromosome. Besides the constellation of phenotypic features that includes short stature, gonadal dysgenesis, coarctation of aorta and renal malformation, patients are also genetically predisposed to developing a variety of autoimmune disorders, including hypothyroidism and coeliac disease . This article is protected by copyright. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13978DOI Listing
March 2019
1 Read

Idiopathic short stature and growth hormone sensitivity in prepubertal children.

Clin Endocrinol (Oxf) 2019 Mar 25. Epub 2019 Mar 25.

Liggins Institute, University of Auckland, Auckland, New Zealand.

Objective: We compared growth hormone sensitivity to an insulin-like growth factor I (IGF-I) generation test in children with idiopathic short stature (ISS) and of normal stature (NS) across the birthweight range.

Methods: Forty-six prepubertal children (~7.1 years) born at term were studied: ISS (n = 23; 74% boys) and NS (n = 23; 57% boys). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13976DOI Listing

Bexarotene-induced hypothyroidism: Characteristics and therapeutic strategies.

Clin Endocrinol (Oxf) 2019 Mar 23. Epub 2019 Mar 23.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Objective: Central hypothyroidism (CH) is a well-known adverse effect of bexarotene treatment for cutaneous T-cell lymphoma (CTCL). While concomitant levothyroxine therapy is recommended in these cases, associations between ethnic variation or susceptibility and bexarotene-induced CH have not yet been reported. This study aimed to characterize the kinetics and dose dependency of bexarotene-induced CH in Japanese patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13975DOI Listing
March 2019
2 Reads

Reversible male hypogonadotropic hypogonadism due to energy deficit.

Clin Endocrinol (Oxf) 2019 Mar 22. Epub 2019 Mar 22.

Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia.

Context: Calorie restriction and overtraining are increasingly seen in young men who suffer from increasing societal pressure to attain a perceived ideal male body image. The resulting energy deficit can lead to multiple endocrine consequences, including suppression of the male gonadal axis.

Design: We reviewed the literature, including two unpublished cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13973DOI Listing

Elevated insulin-like growth factor-1 in Cushing's disease.

Clin Endocrinol (Oxf) 2019 Mar 22. Epub 2019 Mar 22.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Objective: To determine if patients with untreated Cushing's disease have higher serum insulin-like growth factor-1 (IGF-1) compared to matched controls, and if IGF-1 decreases following remission of Cushing's disease.

Design: Retrospective case-control study matching Cushing's disease cases to control patients for adenoma size, age, sex, diabetic and gonadal status, body mass index and serum IGF-1 measured within one year. Paired analysis of pre-operative (untreated) and >3 months post-operative (remission) serum IGF-1 for cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13974DOI Listing

New molecular biomarkers in differentiated thyroid carcinoma: Impact of miR-146, miR-221 and miR-222 levels in the evolution of the disease.

Clin Endocrinol (Oxf) 2019 Mar 18. Epub 2019 Mar 18.

Endocrinology and Nutrition Unit, Virgen de la Victoria University Hospital, Campus Universitario Teatinos SN, Málaga, Spain.

Objective: MircroRNAs (miR) are small, noncoding RNA molecules of 18-25 nucleotides. Their dysregulation has been widely studied in many human tumours including differentiated thyroid cancer (DTC). miRs more frequently associated with these kinds of tumours are miR-146, miR-221 and miR-222. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13972DOI Listing
March 2019
1 Read

Hypothalamic-pituitary axis irradiation dose thresholds for the development of hypopituitarism in adult-onset gliomas.

Clin Endocrinol (Oxf) 2019 Mar 15. Epub 2019 Mar 15.

Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: Childhood brain tumour survivors who receive cranial radiotherapy undergo regular surveillance for the development ofhypothalamic-pituitary (HP) axis dysfunction. Much less attention has been given to radiation-induced hypopituitarism in patients with malignant brain tumours of adult onset.

Design: Retrospective cohort study. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13971
Publisher Site
http://dx.doi.org/10.1111/cen.13971DOI Listing
March 2019
9 Reads

Has GnRH a direct role in AMH regulation?

Clin Endocrinol (Oxf) 2019 Mar 14. Epub 2019 Mar 14.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, Aachen, Germany.

Objective: Anti-Mullerian hormone (AMH) together with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) plays crucial roles in gonadal functions. However, the possible effects of GnRH on AMH via the hypothalamic-pituitary-gonadal (HPG) axis remain unexplored. We aimed to explore the changes in AMH levels after bolus GnRH stimulation and understand the relationship of AMH with FSH and LH in healthy subjects. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cen.13967
Publisher Site
http://dx.doi.org/10.1111/cen.13967DOI Listing
March 2019
11 Reads

Urea in cancer patients with chronic SIAD-induced hyponatremia: Old drug, new evidence.

Clin Endocrinol (Oxf) 2019 Mar 13. Epub 2019 Mar 13.

Oncological Endocrinology Unit, Department of Medical Sciences, Città della Salute e della Scienza Hospital, Turin, Italy.

Background: Syndrome of inappropriate antidiuresis (SIAD) is the main cause of hyponatremia in cancer patients. International guidelines indicate urea as an interesting option for chronic SIAD. Nevertheless, strong data to support its use are lacking, and its role in oncologic patients has not been described so far. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13966DOI Listing
March 2019
4 Reads

The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing.

Clin Endocrinol (Oxf) 2019 Mar 14. Epub 2019 Mar 14.

Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany.

Context: Optimization of hydrocortisone replacement therapy is important to prevent under- and over dosing. Hydrocortisone pharmacokinetics is complex as circulating cortisol is protein bound mainly to corticosteroid-binding globulin (CBG) that has a circadian rhythm.

Objective: A detailed analysis of the CBG circadian rhythm and its impact on cortisol exposure after hydrocortisone administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13969DOI Listing
March 2019
1 Read

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: A randomized controlled study.

Clin Endocrinol (Oxf) 2019 Mar 13. Epub 2019 Mar 13.

Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type-2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular risk; therefore, empagliflozin may be of benefit for these women. The aim of this study was to compare the effects of empagliflozin vs metformin on anthropometric and body composition, hormonal and metabolic parameters in women with PCOS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13968DOI Listing
March 2019
6 Reads
3.457 Impact Factor

Early low-dose rituximab for active thyroid eye disease: An effective and well-tolerated treatment.

Clin Endocrinol (Oxf) 2019 Mar 13. Epub 2019 Mar 13.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease that can be disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long-term sequelae. Current management involves inflammation suppression using glucocorticoids. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cen.13970
Publisher Site
http://dx.doi.org/10.1111/cen.13970DOI Listing
March 2019
5 Reads

Use of Delphian lymph node metastasis to predict central and lateral involvement in papillary thyroid carcinoma: A systematic review and meta-analysis.

Clin Endocrinol (Oxf) 2019 Mar 9. Epub 2019 Mar 9.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

Objective: Whether Delphian lymph node (DLN) metastasis is a reliable predictor of widespread lymph node metastasis in papillary thyroid carcinoma (PTC) remains controversial. This meta-analysis investigated the value of DLN metastasis for predicting central and lateral involvement in PTC.

Design And Methods: A literature search using the PubMed, SCIE and the Chinese National Knowledge Infrastructure (CNKI) databases was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13965DOI Listing
March 2019
1 Read
3.457 Impact Factor

Author's Reply: Does increased 11 β HSD-1 activity induce adverse metabolic phenotype only in lean?

Clin Endocrinol (Oxf) 2019 Mar 4. Epub 2019 Mar 4.

Division of Medical Sciences, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13964DOI Listing

A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Context: Adrenal venous sampling (AVS) is recommended as the gold standard for subtype classification in primary aldosteronism (PA); however, this approach has limited availability.

Objective: We aimed to develop a novel clinical nomogram to predict PA subtype based on routine variables, thereby reducing the number of candidates for AVS.

Patients And Method: Patients were randomly divided into a training set (n = 185) and a validation set (n = 79). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13962DOI Listing
February 2019
8 Reads

A critical assessment of case reports describing absent uterus in subjects with oestrogen deficiency.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Reproductive Medicine Unit, Institute for Women's Health, University College London Hospitals, London, UK.

Objective: The dual diagnosis of hypoplastic uterus in association with ovarian dysgenesis is regularly reported but the pathogenesis of the association is unclear. The uterus, however, may be invisible to all imaging modalities without at least six months of exogenous oestrogen exposure in complete ovarian failure. We assessed all available case reports in this category to estimate whether the apparent association between primary ovarian insufficiency or Turner syndrome and Mullerian agenesis can be largely accounted for by oestrogen deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13963DOI Listing
February 2019
2 Reads

Echocardiography and monitoring patients receiving dopamine agonist therapy for hyperprolactinaemia: A joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology.

Clin Endocrinol (Oxf) 2019 May 28;90(5):662-669. Epub 2019 Feb 28.

Department of Endocrinology, Bartholomew's Hospital, London, UK.

This is a joint position statement of the British Society of Echocardiography, the British Heart Valve Society and the Society for Endocrinology on the role of echocardiography in monitoring patients receiving dopamine agonist (DA) therapy for hyperprolactinaemia. Evidence that DA pharmacotherapy causes abnormal valve morphology and dysfunction at doses used in the management of hyperprolactinaemia is extremely limited. Evidence of clinically significant valve pathology is absent, except for isolated case reports around which questions remain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13940DOI Listing
May 2019
1 Read

Prevalence of low lean mass in patients with adult growth hormone deficiency with or without low-dose growth hormone therapy.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: The importance of muscle mass has been emphasized in various studies, and growth hormone (GH) deficiency is tightly associated with lean mass loss. Therefore, we aimed to investigate the prevalence of low lean mass in patients with adult growth hormone deficiency (AGHD) who received or did not receive GH therapy.

Methods: In this retrospective study, we included patients diagnosed with AGHD by using the insulin tolerance test (ITT) in our hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13958DOI Listing
February 2019
1 Read

Medical therapy in patients with endogenous hypoglycaemia: Is euglycaemia achievable?

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Service d'Endocrinologie, Maladies Métaboliques et Nutrition et Institut CardioMet, Centre Hospitalier Universitaire Rangueil-Larrey, Toulouse, France.

Context: While the only curative treatment for patients with endogenous hypoglycaemia related to inappropriate insulin or to insulin growth factor 2 (IGF2) secretion is surgery, medical treatment to normalize plasma glucose levels can be useful.

Objective: The aim of this prospective single centre study was to assess whether patients with endogenous hypoglycaemia, considered euglycaemic with medical treatments, experienced asymptomatic hypo- or hyperglycaemic excursions.

Patients And Methods: All patients with endogenous hypoglycaemia related to inappropriate insulin or to IGF2 secretion between 2012 and 2016 and considered normoglycaemic with medical treatment (absence of clinical hypoglycaemia and self-monitoring blood glucose in the normal range) were enroled and underwent a six-day continuous glucose monitoring (CGM) recording. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13961DOI Listing
February 2019
2 Reads

Bone mineral density and estimated hip strength in men with anorexia nervosa, atypical anorexia nervosa and avoidant/restrictive food intake disorder.

Clin Endocrinol (Oxf) 2019 Feb 28. Epub 2019 Feb 28.

Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts.

Objective: Few bone mineral density (BMD) data are available in men with anorexia nervosa (AN), and none in those with atypical AN (ATYP) (AN psychological symptoms without low weight) or avoidant/restrictive food intake disorder (ARFID) (restrictive eating without AN psychological symptoms). We investigated the prevalence and determinants of low BMD and estimated hip strength in men with these disorders.

Design: Cross-sectional: two centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13960DOI Listing
February 2019
2 Reads

Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE cohort study.

Clin Endocrinol (Oxf) 2019 Feb 23. Epub 2019 Feb 23.

Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.

Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors.

Design: Prospective cohort.

Patients And Measurements: Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13954DOI Listing
February 2019
1 Read

Is calcium supplementation always needed in patients with hypoparathyroidism?

Clin Endocrinol (Oxf) 2019 Feb 23. Epub 2019 Feb 23.

The Royal Victoria Infirmary, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Oral calcium salts are recommended for the treatment of chronic hypoparathyroidism (HypoPT), although dosimetry is variable between individual patients and clinicians. However, patient feedback on calcium salts can be negative, particularly due to gastrointestinal side effects and hypercalciuria-related complications. We begin with a clinical case of a HypoPT patient taking oral calcium salts following thyroid surgery, who requested support in reducing her dose of these with a view to stopping entirely. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13955DOI Listing
February 2019
2 Reads

Anti-Müllerian hormone variability and its implications for the number of oocytes retrieved following individualized dosing with follitropin delta.

Clin Endocrinol (Oxf) 2019 May 18;90(5):719-726. Epub 2019 Mar 18.

Emeritus Professor University of Utrecht, Utrecht, The Netherlands.

Objective: The stability of anti-Müllerian hormone (AMH) across and between menstrual cycles has been the subject of debate. The objective of this analysis was to study the inter- and intracycle variability in repeated measurements and assess the impact on an individualized gonadotropin dosing algorithm and predicted oocyte yield.

Design: Retrospective analysis of repeat AMH measures from a randomized controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13956DOI Listing
May 2019
1 Read

Physical exercise and Prader-Willi syndrome: A systematic review.

Clin Endocrinol (Oxf) 2019 May 18;90(5):649-661. Epub 2019 Mar 18.

Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.

Objective: The aim of this systematic review was to summarize evidence on the acute responses of individuals with Prader-Willi syndrome (PWS) to physical exercise, and on the effectiveness of long-term exercise interventions to improve the clinical manifestations of this syndrome.

Design/methods: Relevant articles were identified in the electronic databases PubMed, Medline, CINAHL and SPORTDiscus (from inception to December 2018). Twenty-two studies including a total of 356 patients with PWS met all inclusion criteria and were included in the review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13953DOI Listing
May 2019
1 Read

Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome.

Clin Endocrinol (Oxf) 2019 May 7;90(5):766-769. Epub 2019 Mar 7.

Endocrinology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13951DOI Listing
May 2019
1 Read
3.457 Impact Factor

Vitamin D is related to handgrip strength in adult men aged 50 years and over: A population study from the TCLSIH cohort study.

Clin Endocrinol (Oxf) 2019 May 15;90(5):753-765. Epub 2019 Mar 15.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Objective: Handgrip strength (HGS) begins an accelerating decline around 50 years. Many of the studies performed in old adults have demonstrated a significant relationship between vitamin D and HGS, but the studies performed in participants with a broad age range have yielded conflicting results. The purpose of the study was to investigate the relationship between vitamin D and HGS using age 50 as a specific cut-off. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13952DOI Listing
May 2019
5 Reads

Does increased 11 β HSD- 1 activity induce adverse metabolic phenotype only in lean?

Clin Endocrinol (Oxf) 2019 Feb 15. Epub 2019 Feb 15.

Medical College and Hospital Kolkata, Kolkata, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13950DOI Listing
February 2019
3 Reads