13,067 results match your criteria Clinical endocrinology[Journal]


Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome.

Clin Endocrinol (Oxf) 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

16p11.2 microdeletion syndrome is a recognisable chromosomal anomaly caused by microdeletions in the 16p11.2 locus. Read More

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http://dx.doi.org/10.1111/cen.13951DOI Listing
February 2019

Vitamin D is related to hand grip strength in adult men aged 50 years and over: a population study from the TCLSIH cohort study.

Clin Endocrinol (Oxf) 2019 Feb 18. Epub 2019 Feb 18.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Objective: Handgrip strength (HGS) begins an accelerating decline around 50y. Many of the studies performed in old adults have demonstrated a significant relationship between vitamin D and HGS, but the studies performed in participants with a broad age range have yielded conflicting results. The purpose of the study was to investigate the relationship between vitamin D and HGS using age 50 as a specific cutoff. Read More

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http://dx.doi.org/10.1111/cen.13952DOI Listing
February 2019

Does increased 11 β HSD- 1 activity induce adverse metabolic phenotype only in lean ?

Clin Endocrinol (Oxf) 2019 Feb 15. Epub 2019 Feb 15.

Medical College and Hospital Kolkata, Department of Endocrinology and Metabolism, Kolkata, West Bengal, India.

We read with interest article by Crowley et al (1). The authors a found an apparent decrease in 11 β HSD- 1 expression in subcutaneous adipose tissue (SAT) of deteriorators as compared to improvers. They explained it as compensatory decrease of 11 β HSD- 1 activity as consequence of overall adverse metabolic phenotype. Read More

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http://dx.doi.org/10.1111/cen.13950DOI Listing
February 2019
2 Reads

Dedicated neck F-FDG PET/CT: an additional tool for risk assessment in thyroid nodules at ultrasound intermediate risk.

Clin Endocrinol (Oxf) 2019 Feb 11. Epub 2019 Feb 11.

Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Background: Several ultrasound (US) risk stratification systems have been proposed for the assessment of thyroid nodules, and their performance was shown as good. However, the rate of nodules assessed at intermediate risk is not negligible and whether they should be submitted or not to further examination is still under debate. The present study aimed to evaluate the reliability of F-FDG PET/CT in stratifying the risk of malignancy in these lesions. Read More

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http://dx.doi.org/10.1111/cen.13949DOI Listing
February 2019
1 Read

Associations between maternal age at menarche and anthropometric and metabolic parameters in the adolescent offspring.

Clin Endocrinol (Oxf) 2019 Feb 9. Epub 2019 Feb 9.

Endocrinology Department, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Objective: We examined the associations between maternal age at menarche and anthropometry and metabolism in adolescent offspring.

Methods: Anthropometric, metabolic, and blood pressure data were obtained from 304 girls and 190 boys aged 11-16 years attending school in Hangzhou (China). Age at menarche for both mothers and daughters was self-reported. Read More

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http://dx.doi.org/10.1111/cen.13948DOI Listing
February 2019
1 Read

Serum polyamine metabolic profile in autoimmune thyroid disease (AITD) patients.

Clin Endocrinol (Oxf) 2019 Feb 6. Epub 2019 Feb 6.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, China Medical University, Shenyang, Liaoning, P. R. China, 110001.

Objective: Polyamines are indispensable polycations and play important physiological roles in living cells. Some polyamine metabolites have been associated with autoimmune disorders. The aims of this study were to profile polyamine metabolites in autoimmune thyroid disease (AITD) and predict whether polyamine metabolites are associated with thyroid hormone, thyroid autoantibodies or disease progression. Read More

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http://dx.doi.org/10.1111/cen.13946DOI Listing
February 2019
1 Read

Serum iodine concentration in pregnant women and its association with urinary iodine concentration and thyroid function.

Clin Endocrinol (Oxf) 2019 Feb 6. Epub 2019 Feb 6.

Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.

Objective: This study aims to evaluate the association of serum iodine concentration (SIC) with urinary iodine concentration (UIC) and thyroid function in pregnant women, as well as to provide the reference range of SIC of pregnant women in iodine-sufficiency area.

Methods: Pregnant women were enrolled in the Department of Obstetrics, Tanggu Maternity Hospital, Tianjin from March 2016 to May 2017. Fasting venous blood and spot urine samples were collected. Read More

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http://dx.doi.org/10.1111/cen.13945DOI Listing
February 2019
1 Read
3.457 Impact Factor

Sex-specific associations between insulin resistance and bone parameters in overweight and obese older adults.

Clin Endocrinol (Oxf) 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.

Objectives: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography (pQCT) in overweight and obese community-dwelling older adults.

Study Design: Cross-sectional study of 79 community-dwelling overweight and obese adults (mean±SD age 62.8±7. Read More

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http://dx.doi.org/10.1111/cen.13947DOI Listing
February 2019
1 Read

Growth Hormone Therapy and Short Stature-Related Distress: A Randomized Placebo-Controlled Trial.

Clin Endocrinol (Oxf) 2019 Feb 5. Epub 2019 Feb 5.

The Jesse Z and Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva.

Context: Growth hormone (GH) treatment of short healthy children is based on the belief that short stature is associated with psychosocial problems and a diminished quality of life.

Objective: To determine the impact of GH therapy on psychosocial well-being and the ability of psychological metrics to define short stature-related distress.

Methods: Sixty prepubertal boys with idiopathic short stature (age: 10. Read More

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http://dx.doi.org/10.1111/cen.13944DOI Listing
February 2019
1 Read

C-Metomidate PET/CT is a useful adjunct for lateralisation of primary aldosteronism in routine clinical practice.

Clin Endocrinol (Oxf) 2019 Feb 5. Epub 2019 Feb 5.

Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway.

Objective: To describe clinical practice experience of C-Metomidate PET/CT as an adjunct to adrenal vein sampling (AVS) in the lateralization of aldosterone producing adenomas (APA) in primary aldosteronism (PA).

Context: Accurate lateralisation of aldosterone producing adenomas in the setting of primary aldosteronism (PA) offers the potential for surgical cure and improved long-term cardiovascular outcomes. Challenges associated with adrenal vein sampling, the current gold-standard lateralization modality, mean that only a small proportion of potentially eligible patients currently make it through to surgery. Read More

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http://dx.doi.org/10.1111/cen.13942DOI Listing
February 2019
2 Reads

Confirmatory Tests for the Diagnosis of Primary Aldosteronism: A Systematic Review and Meta-analysis.

Clin Endocrinol (Oxf) 2019 Feb 5. Epub 2019 Feb 5.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: Saline infusion test (SIT), captopril challenge test (CCT), fludrocortisone suppression test (FST) and oral sodium loading test (SLT) are recommended by the Endocrine Society's clinical practice guidelines to diagnose primary aldosteronism, but which one is the best remains controversial. We aimed to summarize the available comparative data and evaluate the diagnostic accuracy of these four tests.

Design: We searched PubMed, Embase and the Cochrane Library for relevant studies published between January 1980 and January 2018. Read More

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http://dx.doi.org/10.1111/cen.13943DOI Listing
February 2019
1 Read

Prolongation of tumor volume doubling time (midDT) is associated with improvement in disease specific survival in patients with rapidly progressive radioactive iodine refractory differentiated thyroid cancer selected for molecular targeted therapy.

Clin Endocrinol (Oxf) 2019 Jan 31. Epub 2019 Jan 31.

Endocrinology Service.

Purpose: To assess molecular targeted therapy (MTT) 's ability to affect tumor volume doubling time (TVDT) and disease specific survival (DSS) in patients presenting with lung metastasis from radioactive iodine refractory progressive thyroid cancer.

Methods: In this retrospective study, we examined the clinical characteristics, average tumor volume doubling times of lung metastasis and disease specific survival of patients with lung metastasis from differentiated thyroid cancer who were treated with MTT.

Results: The 5-year DSS from the distant metastasis (DM) diagnosis was 72% with median survival of 8 years (95% CI: 6. Read More

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http://dx.doi.org/10.1111/cen.13941DOI Listing
January 2019

Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance - a longitudinal cohort study.

Clin Endocrinol (Oxf) 2019 Jan 22. Epub 2019 Jan 22.

Oxford Centre for Diabetes Endocrinology& Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK.

Objective & Context: Increasing adiposity, aging and tissue-specific regeneration of cortisol through the activity of 11β-hydroxysteroid dehydrogenase type 1 have been associated with deterioration in glucose tolerance. We undertook a longitudinal, prospective clinical study to determine if alterations in local glucocorticoid metabolism track with changes in glucose tolerance.

Design, Patients, Measurements: 65 overweight/obese individuals (mean age 50. Read More

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http://doi.wiley.com/10.1111/cen.13939
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http://dx.doi.org/10.1111/cen.13939DOI Listing
January 2019
3 Reads

Comparison between radioiodine therapy and single-session radiofrequency ablation of autonomously functioning thyroid nodules: A retrospective study.

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.

Objective: To compare the efficacy of Radioiodine (RI) and Radiofrequency ablation (RFA) in the treatment of autonomously functioning thyroid nodules (AFTNs). End-points: nodule volume reduction (NVR) and thyroid function normalization.

Design, Patients And Measurements: Twenty-two patients (2:20 M:F; 51. Read More

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http://dx.doi.org/10.1111/cen.13938DOI Listing
January 2019
2 Reads

Insulin resistance is associated with hirsutism in unselected reproductive-aged women.

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Objective: Hirsutism affects 5%-10% of reproductive-aged women worldwide and exhibits clinical importance as a cutaneous manifestation of underlying hyperandrogenism. Racial and genetic factors play roles in manifestation of hirsutism, and the prevalence of hirsutism seems to be low in East Asians. However, the reference value of the modified Ferriman-Gallwey (mFG) score to diagnose hirsutism and the prevalence of hirsutism have not been determined in Korean populations to date. Read More

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http://dx.doi.org/10.1111/cen.13936DOI Listing
January 2019
2 Reads

Hyponatraemia in patients with community acquired pneumonia; prevalence and etiology, and natural history of siad.

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Academic Departments of Endocrinology, Chemical Pathology, Beaumont Hospital, RCSI Medical School.

Objective: Hyponatraemia is common in community acquired pneumonia (CAP) and is associated with increased mortality. The mechanism of hyponatraemia in CAP is not completely understood and treatment is therefore ill-defined. We aimed to define the causation of hyponatraemia in CAP. Read More

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http://doi.wiley.com/10.1111/cen.13937
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http://dx.doi.org/10.1111/cen.13937DOI Listing
January 2019
5 Reads

Clinical outcomes and cortical reserve in adrenal histoplasmosis-A retrospective follow-up study of 40 patients.

Clin Endocrinol (Oxf) 2019 Jan 17. Epub 2019 Jan 17.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objective: Detailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy.

Design: Single-centre retrospective hospital-based study of 40 consecutive adults with AH [39 males; age (mean ± SD) 53 ± 11 years] was conducted between 2006 and 2018. Read More

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http://doi.wiley.com/10.1111/cen.13935
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http://dx.doi.org/10.1111/cen.13935DOI Listing
January 2019
7 Reads

Exploration of the role of anti-Mullerian hormone and LH/FSH ratio in diagnosis of polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2019 Jan 13. Epub 2019 Jan 13.

Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.

Objective: This study explores the role of anti-Mullerian hormone (AMH) and LH/FSH ratio in diagnosis of polycystic ovary syndrome (PCOS).

Methods: In this multicentre cross-sectional descriptive study, a total of 863 infertile women between 18 and 45 years were evaluated at three infertility centres in Vietnam and were recruited from June 2016 to June 2017. The patients were classified into two groups: Group I included 441 patients with PCOS (based on Rotterdam criteria consensus) and Group II included 422 non-PCOS women. Read More

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http://dx.doi.org/10.1111/cen.13934DOI Listing
January 2019
2 Reads

Adipocyte expression of glucose transporter 1 and 4 in PCOS: Relationship to insulin-mediated and non-insulin-mediated whole-body glucose uptake.

Clin Endocrinol (Oxf) 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics & Gynecology and Center for Androgen-Related Disorders, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder associated with insulin resistance (IR). In IR states, non-insulin-mediated glucose uptake (NIMGU) may increase to compensate for declining insulin-mediated glucose uptake (IMGU), although this does not appear to be the case in PCOS. The underlying molecular mechanisms for this deficiency remain unclear. Read More

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http://doi.wiley.com/10.1111/cen.13931
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http://dx.doi.org/10.1111/cen.13931DOI Listing
January 2019
5 Reads

Adolescent use of combined hormonal contraception and peak bone mineral density accrual: A meta-analysis of international prospective controlled studies.

Clin Endocrinol (Oxf) 2019 Jan 7. Epub 2019 Jan 7.

Centre for Menstrual Cycle and Ovulation Research, Endocrinology and Metabolism, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: Many women use combined hormonal contraceptives (CHC) during adolescence during which they are accruing peak areal bone mineral density (BMD) that relates to lifetime fracture risk. To build BMD requires formation with which CHC-related exogenous oestrogen may interfere. We compared peak BMD accrual in adolescents using and not using CHC. Read More

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http://doi.wiley.com/10.1111/cen.13932
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http://dx.doi.org/10.1111/cen.13932DOI Listing
January 2019
5 Reads

Urea treatment in fluid restriction-refractory hyponatraemia.

Clin Endocrinol (Oxf) 2019 Jan 7. Epub 2019 Jan 7.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

Objective: Hyponatraemia in hospitalized patients is common and associated with increased mortality. International guidelines give conflicting advice regarding the role of urea in the treatment of SIADH. We hypothesized that urea is a safe, effective treatment for fluid restriction-refractory hyponatraemia. Read More

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http://dx.doi.org/10.1111/cen.13930DOI Listing
January 2019
2 Reads

Hormonal and metabolic effects of carbohydrate restriction in children with Prader-Willi syndrome.

Clin Endocrinol (Oxf) 2019 Jan 7. Epub 2019 Jan 7.

Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina.

Objective: Macronutrient regulation of hyperphagia and adiposity in Prader-Willi syndrome (PWS) is poorly understood. We compared fasting and postprandial concentrations of hormones and metabolites in eight PWS children (age 9-18 years) fed, in random order, low carbohydrate, high-fat (LC, 15% carb; 65% fat; 20% protein) and low-fat, high carbohydrate (LF, 65% carb, 15% fat, 20% protein) diets matched for calories and protein.

Methods: Participants were randomized to consume either the LC or LF diet during a first hospital admission and the second diet during a subsequent admission. Read More

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http://dx.doi.org/10.1111/cen.13933DOI Listing
January 2019
1 Read

Management of hypothalamic disease in patients with craniopharyngioma.

Clin Endocrinol (Oxf) 2019 Jan 4. Epub 2019 Jan 4.

Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

Patients with craniopharyngioma experience excess morbidity and mortality when compared with the background population and with other hypopituitary patients. Large, suprasellar tumours which form micropapillae into surrounding structures can cause hypothalamic damage before any therapeutic intervention; attempted gross total resection can lead to hypothalamic obesity, sleep disorders, thirst disorders and dysregulation of temperature as well as panhypopituitarism. The management of tumour bulk and the pathophysiology of hypothalamic complications have been reviewed extensively. Read More

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http://doi.wiley.com/10.1111/cen.13929
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http://dx.doi.org/10.1111/cen.13929DOI Listing
January 2019
3 Reads

BRAF-positive multifocal and unifocal papillary thyroid cancer show different messenger RNA expressions.

Clin Endocrinol (Oxf) 2018 Dec 28. Epub 2018 Dec 28.

Department of Anatomy and Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Korea.

Objective: Thyroid cancer is the most common malignant endocrine tumour, and its incidence has continuously increased worldwide over the past three decades. We focused on the association of multifocal papillary thyroid carcinoma (PTC) with messenger RNA (mRNA) expression to characterize how molecular and histopathologic features relate to multifocality.

Design: A retrospective cohort study. Read More

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http://doi.wiley.com/10.1111/cen.13928
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http://dx.doi.org/10.1111/cen.13928DOI Listing
December 2018
9 Reads

Cardiovascular findings in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism: A cohort study.

Clin Endocrinol (Oxf) 2018 Dec 27. Epub 2018 Dec 27.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Objective: As only sparse data are available on indices of cardiovascular health among patients with nonsurgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP), we aimed to compare the cardiovascular profile between these groups of patients.

Methods: A total of 56 patients with Ns-HypoPT and 30 with PHP were included and underwent a clinical examination including blood sampling and measurements of arterial stiffness, pulse wave velocity (PWV) and blood pressure (BP). Arterial stiffness and PWV were measured using AtCor SphygmoCor-XCEL (Atcor Medical Pty Ltd, Sydney, NSW, Australia). Read More

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http://dx.doi.org/10.1111/cen.13927DOI Listing
December 2018
3 Reads

Clinical Practice Guidance: Surveillance for phaeochromocytoma and paraganglioma in paediatric succinate dehydrogenase gene mutation carriers.

Clin Endocrinol (Oxf) 2018 Dec 27. Epub 2018 Dec 27.

Department of Diabetes and Endocrinology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

The succinate dehydrogenase (SDH) enzyme complex functions as a key enzyme coupling the oxidation of succinate to fumarate in the citric acid cycle. Inactivation of this enzyme complex results in the cellular accumulation of the oncometabolite succinate, which is postulated to be a key driver in tumorigenesis. Succinate accumulation inhibits 2-oxoglutarate-dependent dioxygenases, including DNA and histone demethylase enzymes and hypoxic gene response regulators. Read More

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http://dx.doi.org/10.1111/cen.13926DOI Listing
December 2018
4 Reads

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure.

Clin Endocrinol (Oxf) 2019 Mar 17;90(3):440-448. Epub 2019 Jan 17.

Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.

Background: Chronic hepatitis C (CHC) is associated with systemic insulin resistance, yet there are limited data on the tissue-specific contribution in vivo to this adverse metabolic phenotype, and the effect of HCV cure.

Methods: We examined tissue-specific insulin sensitivity in a cohort study involving 13 patients with CHC compared to 12 BMI-matched healthy control subjects. All subjects underwent a two-step clamp incorporating the use of stable isotopes to measure carbohydrate and lipid flux (hepatic and global insulin sensitivity) with concomitant subcutaneous adipose tissue microdialysis and biopsy (subcutaneous adipose tissue insulin sensitivity). Read More

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http://doi.wiley.com/10.1111/cen.13924
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http://dx.doi.org/10.1111/cen.13924DOI Listing
March 2019
6 Reads

Research on indocyanine green angiography for predicting postoperative hypoparathyroidism.

Clin Endocrinol (Oxf) 2019 Mar 7;90(3):487-493. Epub 2019 Jan 7.

The Second Department of General Surgery, Zhuhai People's Hospital, Zhuhai City, Guangdong Province, China.

Background: It may be critical to locate the parathyroid for surgeons during thyroidectomy or parathyroidectomy due to the significant function of the parathyroid in calcium balance. According to recent reports, the intrinsic fluorescence of the parathyroid has been found. There is some evidence supporting that new equipment can detect fluorescence via imaging technology. Read More

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http://dx.doi.org/10.1111/cen.13925DOI Listing
March 2019
3 Reads

Sleep disturbances in women with and without polycystic ovary syndrome in an Australian National Cohort.

Clin Endocrinol (Oxf) 2018 Dec 26. Epub 2018 Dec 26.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Background: Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women. Sleep disturbances may be more prevalent in PCOS. It is not known if this relationship is independent of other factors. Read More

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http://doi.wiley.com/10.1111/cen.13922
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http://dx.doi.org/10.1111/cen.13922DOI Listing
December 2018
12 Reads

A simulation study assessing the accuracy and reliability of orchidometer estimation of testicular volume.

Clin Endocrinol (Oxf) 2018 Dec 26. Epub 2018 Dec 26.

Department of Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, UK.

Context: Measuring testicular volume (TV) by orchidometer is the standard method of male pubertal staging. A paucity of evidence exists as to its inter- and intra-observer reliability and the impact of clinicians' gender, training and experience on accuracy.

Objective: Prosthetic testicular models were engineered to investigate accuracy and reliability of TV estimation. Read More

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http://dx.doi.org/10.1111/cen.13923DOI Listing
December 2018
1 Read

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females.

Clin Endocrinol (Oxf) 2019 Mar 9;90(3):433-439. Epub 2019 Jan 9.

Aging and Muscle Metabolism Laboratory, Department of Physiology, School of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Objective: Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.

Design: Observational, cross-sectional study of healthy, community dwelling postmenopausal women. Read More

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http://dx.doi.org/10.1111/cen.13921DOI Listing
March 2019
1 Read

Rates of abnormal aldosterone/renin ratio in African-origin compared to European-origin patients: A retrospective study.

Clin Endocrinol (Oxf) 2018 Dec 21. Epub 2018 Dec 21.

Department of Endocrinology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital, Tallaght, Dublin, Ireland.

Introduction: The aldosterone/renin ratio is the initial screening test for primary hyperaldosteronism (PHA), but little data exists regarding ethnic variations in this.

Methods: Following clinical observation of a high prevalence of abnormal aldosterone/renin ratio (ARR) in patients of African-origin, we retrospectively reviewed all ARR measurements in a single centre over 10 years. Rates of hypokalaemia, intraventricular septal thickness (IVS, by echocardiography) and adrenal imaging were recorded when available. Read More

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http://dx.doi.org/10.1111/cen.13920DOI Listing
December 2018
4 Reads

Improved menstrual function in obese women with polycystic ovary syndrome after behavioural modification intervention-A randomized controlled trial.

Clin Endocrinol (Oxf) 2019 Mar 15;90(3):468-478. Epub 2019 Jan 15.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Objective: Lifestyle intervention is the recommended first-line treatment for overweight women with polycystic ovary syndrome (PCOS). However, the efficacy of lifestyle change in improving reproductive function is still unclear.

Design: A randomized controlled trial (RCT) with allocation to a behavioural modification programme (intervention) or minimal intervention (control) for 4 months with a follow-up at 12 months. Read More

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http://dx.doi.org/10.1111/cen.13919DOI Listing
March 2019
2 Reads

Cross-sectional associations of sex hormones with leucocyte telomere length, a marker of biological age, in a community-based cohort of older men.

Clin Endocrinol (Oxf) 2018 Dec 18. Epub 2018 Dec 18.

PathWest Laboratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

Context: Telomeres protect chromosomes from damage, and shorter leucocyte telomere length (LTL) is a marker of advancing biological age. The association between testosterone (T) and its bioactive metabolites, dihydrotestosterone (DHT) and oestradiol (E2) with telomere length, particularly in older men, is uncertain. The study aimed to clarify associations of sex hormones with LTL in older men. Read More

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http://dx.doi.org/10.1111/cen.13918DOI Listing
December 2018
1 Read

Erratum.

Authors:

Clin Endocrinol (Oxf) 2019 Jan;90(1):252

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http://dx.doi.org/10.1111/cen.13912DOI Listing
January 2019
1 Read

Combined immunosuppressants and less steroids in active graves' orbitopathy?

Clin Endocrinol (Oxf) 2018 Dec 14. Epub 2018 Dec 14.

Graves' Orbitopathy Center, Endocrinology, Fondazione IRCCS Cà Granda, University of Milan, Milan, Italy.

Steroid therapy in GO is first-line treatment but has limitations, as it is potentially harmful at high doses and often refused by patients. A steroid-sparing therapy is a reasonable option as long as it is rapidly effective and devoid of long-term adverse reactions. Combined immunosuppressive therapy must be studied in randomized clinical trials designed to test efficacy and the potentially increased risk of side effects. Read More

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http://dx.doi.org/10.1111/cen.13917DOI Listing
December 2018
1 Read

Quality of life is significantly impaired in both secretory and non-functioning pituitary adenomas.

Clin Endocrinol (Oxf) 2019 Mar 15;90(3):457-467. Epub 2019 Jan 15.

Neuroendocrinology Clinic, Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Objective: To evaluate the quality of life (QoL) in patients with pituitary adenomas in comparison with healthy Mexican population QoL scores.

Design & Measurements: Cross-sectional study using the short form 36 questionnaire (SF-36) in 175 patients with pituitary adenomas grouped by adenoma subtype and disease activity, and compared them with the healthy Mexican population normative QoL scores.

Patients: A total of 44 patients with non-functioning pituitary adenomas (NFPA), 48 with acromegaly, 53 with prolactinomas and 30 with Cushing disease (CD) were enrolled in this study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13915
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http://dx.doi.org/10.1111/cen.13915DOI Listing
March 2019
4 Reads

Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization.

Clin Endocrinol (Oxf) 2019 Mar 7;90(3):449-456. Epub 2019 Jan 7.

Laboratory of Genetics, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.

Context: The Gli-family of zinc-finger transcription factors regulates the Sonic Hedgehog (Shh) signalling pathway that plays a key role in early pituitary and ventral forebrain development. Heterozygous GLI2 loss of function mutations in humans have been reported in holoprosencephaly (HPE), HPE-like phenotypes associated with pituitary anomalies and combined pituitary hormone deficiency with or without other extra-pituitary findings.

Objective: The aim of this study was the search for GLI2 mutations in a cohort of Italian CPHD patients and the assessment of a pathogenic role for the identified variants through in vitro studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13914
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http://dx.doi.org/10.1111/cen.13914DOI Listing
March 2019
10 Reads

The time point of completion thyroidectomy has no prognostic impact in patients with differentiated thyroid cancer.

Clin Endocrinol (Oxf) 2019 Mar 28;90(3):479-486. Epub 2018 Dec 28.

Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.

Background: After partial resection of the thyroid gland, a second operation referred to as "completion thyroidectomy" may be required if histopathological analysis indicates the presence of differentiated thyroid cancer (DTC). Although there is little evidence, it is assumed that the time point of completion thyroidectomy is not critical for oncological prognosis of patients with DTC. We assessed whether patients with total thyroidectomy (TTx) in a two-step procedure have an equal long-term prognosis with regard to disease-specific survival (DSS) compared to patients immediately undergoing total thyroidectomy in a one-step procedure. Read More

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http://dx.doi.org/10.1111/cen.13916DOI Listing
March 2019
1 Read

Brown adipose tissue thermogenesis in polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2019 Mar 7;90(3):425-432. Epub 2019 Jan 7.

Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Objective: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation have not been studied in PCOS. Read More

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http://dx.doi.org/10.1111/cen.13913DOI Listing
March 2019
12 Reads

Poorly differentiated thyroid cancer in the context of the revised 2015 American Thyroid Association Guidelines and the Updated American Joint Committee on Cancer/Tumor-Node-Metastasis Staging System (eighth edition).

Clin Endocrinol (Oxf) 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Holycross Cancer Center, Kielce, Poland.

Objective: Poorly differentiated thyroid cancer (PDTC) is a rare, but aggressive thyroid cancer (TC) and a main cause of death from non-anaplastic follicular cell-derived TC. Assessing the risk of PDTC-related death and the risk of recurrence is important for clinicians. The recent American Thyroid Association (ATA) 2015 guidelines and the updated 8th edition of the American Joint Committee on Cancer/Tumor-Node-Metastasis (AJCC/TNM) staging system should support clinicians in the management approach to PDTC patients. Read More

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http://dx.doi.org/10.1111/cen.13910DOI Listing
December 2018
6 Reads

Oxytocin therapy in hypopituitarism: Challenges and opportunities.

Clin Endocrinol (Oxf) 2019 Feb 17;90(2):257-264. Epub 2018 Dec 17.

Schools of Medicine (RB, DAR) and Psychology (KLD), Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Read More

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http://dx.doi.org/10.1111/cen.13909DOI Listing
February 2019
3 Reads

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women.

Clin Endocrinol (Oxf) 2019 Mar 14;90(3):391-414. Epub 2019 Jan 14.

Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, UK.

The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomized, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women. Read More

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http://doi.wiley.com/10.1111/cen.13906
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http://dx.doi.org/10.1111/cen.13906DOI Listing
March 2019
7 Reads

Cosyntropin testing does not predict response to glucocorticoids in community-acquired pneumonia in a randomized controlled trial.

Clin Endocrinol (Oxf) 2018 Nov 28. Epub 2018 Nov 28.

Endocrinology, Diabetology and Metabolism, Department of Internal Medicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.

Objective: Glucocorticoids have been shown to improve outcome in community-acquired pneumonia (CAP). However, glucocorticoids have potential side-effects, and treatment response may vary. It is thus crucial to select patients with high likelihood to respond favourably. Read More

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http://dx.doi.org/10.1111/cen.13907DOI Listing
November 2018
2 Reads

Thyrotrophin receptor antibody concentration and activity, several years after treatment for Graves' disease.

Clin Endocrinol (Oxf) 2019 Feb 17;90(2):369-374. Epub 2018 Dec 17.

Section of Endocrinology and Biochemistry, Aneurin Bevan University Health Board, Caerphilly, UK.

Objective: TSH receptor antibodies (TRAb) are responsible for autoimmune hyperthyroid disease (Graves' disease; GD) with TRAb levels tending to decrease following treatment. Measurement of TRAb activity during follow-up could prove valuable to better understand treatment effectiveness.

Study Design: TRAb concentration and stimulating (TSAb) and blocking (TSBAb) activity of patient serum were assessed following different treatment modalities and follow-up length. Read More

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http://dx.doi.org/10.1111/cen.13908DOI Listing
February 2019
2 Reads

Higher circulating androgens and higher physical activity levels are associated with less central adiposity and lower risk of cardiovascular death in older men.

Clin Endocrinol (Oxf) 2019 Feb 21;90(2):375-383. Epub 2018 Dec 21.

Medical School, University of Western Australia, Perth, Western Australia, Australia.

Objective: Low endogenous sex hormones and low physical activity (PA) levels have been associated with CVD risk. Whether these interact to influence CVD outcomes remains unclear. We assessed whether sex hormone concentrations and PA were additively associated with lower central adiposity and CVD risk. Read More

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http://doi.wiley.com/10.1111/cen.13905
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http://dx.doi.org/10.1111/cen.13905DOI Listing
February 2019
6 Reads

Nomograms for incident risk of post-partum type 2 diabetes in Chinese women with gestational diabetes.

Clin Endocrinol (Oxf) 2019 Mar 10;90(3):415-416. Epub 2018 Dec 10.

Deakin Rural Health, School of Medicine, Faculty of Health, Deakin University, Warrnambool, Victoria, Australia.

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http://doi.wiley.com/10.1111/cen.13904
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http://dx.doi.org/10.1111/cen.13904DOI Listing
March 2019
7 Reads

Changes of computed tomography-based body composition after adrenalectomy in patients with endogenous hypercortisolism.

Clin Endocrinol (Oxf) 2019 Feb 9;90(2):267-276. Epub 2018 Dec 9.

Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Context: Data on longitudinal changes of computed tomography (CT)-determined visceral fat area (VFA), skeletal muscle area (SMA) and skeletal muscle radiodensity (SMD) after adrenalectomy are limited in patients with hypercortisolism.

Objective: To examine the association of severity of cortisol excess and improvement of CT-based muscle and fat parameters after adrenalectomy.

Design: Retrospective observational cohort study. Read More

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http://doi.wiley.com/10.1111/cen.13902
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http://dx.doi.org/10.1111/cen.13902DOI Listing
February 2019
7 Reads

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.

Clin Endocrinol (Oxf) 2019 Feb 9;90(2):293-300. Epub 2018 Dec 9.

University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Objective: Studies of dehydroepiandrosterone (DHEA) therapy in older adults suggest sex-specific effects on bone mineral density (BMD) and body composition, but the ability of a single study to reach this conclusion was limited. We evaluated the effects of DHEA on sex hormones, BMD, fat mass and fat-free mass in older women and men enrolled in four similar clinical trials.

Design: Pooled analyses of data from four double-blinded, randomized controlled trials. Read More

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http://doi.wiley.com/10.1111/cen.13901
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http://dx.doi.org/10.1111/cen.13901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336516PMC
February 2019
9 Reads

Commentary: The New International Guideline for diagnosis and management of PCOS was worth the effort.

Authors:
Stephen Franks

Clin Endocrinol (Oxf) 2019 Feb 27;90(2):265-266. Epub 2018 Nov 27.

Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, London, UK.

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http://doi.wiley.com/10.1111/cen.13900
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http://dx.doi.org/10.1111/cen.13900DOI Listing
February 2019
14 Reads