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    6204 results match your criteria Clinical cardiology[Journal]

    1 OF 125

    Is self-rated health associated with ideal cardiovascular health? The Multi-Ethnic Study of Atherosclerosis.
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD.
    Background: Self-rated health (SRH) is an indicator of health status. It is a determinant of health-promoting behaviors and predictor of morbidity and mortality. Yet, little is known about the association between SRH and ideal cardiovascular health (CVH) as measured by the American Heart Association Life's Simple Seven (LS7) metrics, or whether the relation of SRH and CVH differ by race/ethnicity. Read More

    Galectin-3 and ST2 as predictors of therapeutic success in high-risk patients undergoing percutaneous mitral valve repair (MitraClip).
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Cardiology, University of Giessen, Giessen, Germany.
    Background: Percutaneous mitral valve repair (PMVR) is an interventional treatment option in patients with severe mitral regurgitation (MR) who have a high risk for open-heart surgery. Currently, there is limited information about predictors of procedural success after PMVR. Galectin-3 (Gal-3) and ST2 induce fibrotic alterations in severe MR and heart failure. Read More

    Right Ventricular Base/Apex Ratio in the Assessment of Pediatric Pulmonary Arterial Hypertension - Results from the European Pediatric Pulmonary Vascular Disease Network.
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.
    Background: Echocardiographic determination of the RV end-systolic base/apex (RVESb/a) ratio was proposed to be of clinical value for the assessment of pulmonary arterial hypertension (PAH) in adults.

    Hypothesis: We hypothesized that the RVES b/a ratio will be affected in children with PAH and aimed to correlate the RVES b/a ratio with conventionally used echocardiographic and hemodynamic variables, and with NYHA functional class (FC).

    Methods: We first determined normal pediatric values for the RVES b/a ratio in 157 healthy children (68 male; age range: 0. Read More

    Advanced Chronic Kidney Disease: Relationship to Outcomes Post TAVR, A Meta-Analysis.
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Cardiology, Ohio State University Wexner Medical Center, Columbus, OH.
    Objective: Chronic kidney (CKD) is associated with worse outcomes in high-surgical risk patients undergoing transcatheter aortic valve replacement (TAVR). However, it is unclear whether this relationship is apparent in lower surgical risk patients. Herein we sought to analyze existing literature to assess whether or not advanced CKD is associated with increased mortality, or a greater incidence of adverse events (specifically major stroke, bleeding and vascular complications). Read More

    Comparing outcomes after Transcatheter aortic valve replacement in patients with stenotic bicuspid and tricuspid aortic valve: A systematic review and meta-analysis.
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    University of Hawaii Internal Medicine Residency Program, Honolulu, Hawaii.
    Background: Transcatheter aortic valve replacement (TAVR) has become an alternative treatment to surgery in patients with severe aortic stenosis (AS). However, patients with Bicuspid aortic stenosis (BiAV) are usually excluded from major TAVR studies. The aim of this study is to reexamine the current evidence of TAVR in patients with severe AS and BiAV comparing to tricuspid aortic valve (TriAV). Read More

    Use of the adapted diabetes complications severity index to predict acute coronary syndrome, ischemic stroke and mortality in Asian patients with type 2 diabetes mellitus: a nationwide cohort investigation.
    Clin Cardiol 2018 Jun 12. Epub 2018 Jun 12.
    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
    Objective: We report a retrospective population study aiming at identifying and validating the adapted diabetes complications severity index (DCSI) for acute coronary syndrome (ACS), ischemic stroke and mortality in Asian people with type 2 diabetes mellitus (DM).

    Methods: Utilizing the Taiwanese national dataset, we included 84450 type 2 diabetic individuals between 2000 and 2011. The area under the curve in the presentation of receiver operating characteristic (C-statistics of logistic model) and the C-statistics of Cox model were used to evaluate whether the progression of type 2 DM could be a predictor of ACS, ischemic stroke and death. Read More

    A review of factors associated with maintenance of sinus rhythm after elective electrical cardioversion for atrial fibrillation.
    Clin Cardiol 2018 Jun 7. Epub 2018 Jun 7.
    NHS Highland, Assynt House, Beechwood Park, Inverness, UK.
    Atrial fibrillation is the most common heart-rhythm disorder, affecting about 1.5% to 2% of the population with an increased risk of mortality and morbidity due to stroke, thromboembolism, and heart failure. If the conversion back to sinus rhythm does not happen spontaneously, pharmacological or electrical cardioversion (ECV) is the next available treatment options for some patients. Read More

    A clinical and proteomics approach to predict the presence of obstructive peripheral arterial disease: From the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study.
    Clin Cardiol 2018 Jun 6. Epub 2018 Jun 6.
    Division of Cardiology, Massachusetts General Hospital, Boston.
    Background: Peripheral arterial disease (PAD) is a global health problem that is frequently underdiagnosed and undertreated. Noninvasive tools to predict the presence and severity of PAD have limitations including inaccuracy, cost, or need for intravenous contrast and ionizing radiation.

    Hypothesis: A clinical/biomarker score may offer an attractive alternative diagnostic method for PAD. Read More

    High prevalence of occult heart disease in normotensive patients with rheumatoid arthritis.
    Clin Cardiol 2018 Jun 5. Epub 2018 Jun 5.
    Division of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Background: Due to chronic inflammatory status, rheumatoid arthritis (RA) patients are exposed to changes in left ventricular (LV) geometry and function. We assessed prevalence, factors associated with, and prognostic role of concentric LV geometry and systolic dysfunction (LVSD) detected by echocardiography in a large cohort of patients with RA and normal blood pressure.

    Hypothesis: Changes in LV geometry and function are widely detectable in normotensive patients with RA analyzed in primary prevention. Read More

    Transient manifestation of left ventricular diastolic dysfunction following ablation in patients with paroxysmal atrial fibrillation.
    Clin Cardiol 2018 Jun 4. Epub 2018 Jun 4.
    Department of Cardiovascular Medicine, Yao Municipal Hospital, Osaka, Japan.
    Background: In patients with atrial fibrillation, ablation procedure decreases left atrial (LA) compliance, which may lead to left ventricular (LV) diastolic dysfunction. We aimed to examine serial changes in LV diastolic function after two ablation procedures and their related factors in patients with paroxysmal atrial fibrillation (PAF).

    Methods: We enrolled 132 patients with PAF [76 men, cryoballoon (CB) ablation/radiofrequency (RF) ablation 60/72, mean 67 years] who underwent a single ablation procedure. Read More

    Response to Trends, etiologies, and predictors of 90-day readmission after percutaneous ventricular assist device implantation: A national population-based cohort study.
    Clin Cardiol 2018 Jun 4. Epub 2018 Jun 4.
    Wayne State University/Detroit Medical Center, Heart Hospital, Detroit, Michigan.
    We read with interest Virk et al's recent informative study regarding trends, etiologies and predictors of 90-day readmission after percutaneous ventricular assist device (pVAD) implantation. We have a number of comments and concerns regarding this article. This article is protected by copyright. Read More

    Electrocardiographic diagnosis of atrial infarction in patients with acute inferior ST-segment elevation myocardial infarction.
    Clin Cardiol 2018 May 26. Epub 2018 May 26.
    Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
    Background: Patients with atrial myocardial infarction (ATMI) have frequent cardiac and noncardiac complications. However, ATMI is uncommonly diagnosed because of its nonspecific electrocardiographic changes.

    Hypothesis: Our objective was to analyze the electrocardiographic characteristic of ATMI in patients with inferior STEMI. Read More

    Author Response to LTE CLC 22970 of John Madias: Brain-heart pathway to injury in takotsubo syndrome.
    Clin Cardiol 2018 May 26. Epub 2018 May 26.
    Department of Neurological and Movement Sciences, University Hospital of Verona, Italy.
    We would like to thank John Madias for his interest in our review about the mystery of the pathogenesis of Takotsubo cardiomyopathy (TC) . We agree with his semantic restraint of the eponym Wellens electrocardiographic (ECG) pattern, which needs a contextual disambiguation. Indeed, as stressed by Dr. Read More

    Prevalence and outcome of patients referred for chest pain with high sensitivity troponin elevation and no diagnosis at discharge.
    Clin Cardiol 2018 May 26. Epub 2018 May 26.
    CHU de Poitiers, Poitiers, France.
    Introduction: Specialized chest pain units (CPU) appear to increase the proportion of patients with acute chest pain who are properly evaluated. The aim of this study was to evaluate the survival and occurrence of cardiovascular events in patients without diagnosis at the end of the management of chest pain with high-sensibility troponin elevation.

    Method: All consecutive patients who came to the cardiac emergency room of Poitiers University Hospital between January 1, 2014 and August 7, 2015 for chest pain and troponin elevation were included. Read More

    Optimal timing for cardioversion in patients with atrial fibrillation.
    Clin Cardiol 2018 May 26. Epub 2018 May 26.
    Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
    Background: Electrical cardioversion (CV) is essential in rhythm management of atrial fibrillation (AF). However, optimal timing of CV remains unknown.

    Hypothesis: Timing of CV in AF is associated with the risk of adverse events. Read More

    Impact of Lung Function Measures on Cardiovascular Disease Events in Older Adults with Metabolic Syndrome and Diabetes.
    Clin Cardiol 2018 May 24. Epub 2018 May 24.
    Heart Disease Prevention Program, Division of Cardiology, University of California Irvine School of Medicine, Irvine, CA.
    Background: Individuals with metabolic syndrome (MetS) and diabetes (DM) are more likely to have decreased lung function and are at greater risk of cardiovascular disease (CVD).

    Hypothesis: We tested the hypothesis that lung function measures would predict CVD events in older persons with MetS, DM, and neither condition.

    Methods: We followed 4,114 participants aged >65 in the Cardiovascular Health Study with and without MetS or DM. Read More

    Pre-operative Dobutamine Stress Echocardiography in Patients Undergoing Orthotopic Liver Transplantation.
    Clin Cardiol 2018 May 20. Epub 2018 May 20.
    The stress echocardiography laboratory, Heart and Vascular Institute.
    Background: Coronary artery disease (CAD) is associated with increased mortality in patients that undergo orthotopic liver transplantation (OLT). Due to chronic vasodilatory state and poor exercise tolerance in patients with end stage liver disease, dobutamine stress echocardiography (DSE) is preferred for preoperative evaluation of CAD prior to OLT. We sought to a) study the incidence of positive DSE results and b) test whether there is an association between DSE results and perioperative and longer-term events. Read More

    Rate pressure product and the components of heart rate and systolic blood pressure in hospitalized heart failure patients with preserved ejection fraction: Insights from ASCEND-HF.
    Clin Cardiol 2018 May 20. Epub 2018 May 20.
    Duke University Medical Center, Durham, NC.
    Background: Heart rate (HR) and systolic blood pressure (SBP) are prognostic markers in heart failure with reduced ejection fraction (HFrEF). Their combination in rate-pressure product (RPP) as well as their role in heart failure with preserved ejection fraction (HFpEF) remains unclear.

    Methods: We performed an analysis of ASCEND-HF (clinicaltrials. Read More

    Influence of sex and pregnancy on survival in patients admitted with heart failure. Data from a prospective multicenter registry.
    Clin Cardiol 2018 May 17. Epub 2018 May 17.
    Cardiology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Background: Female sex is an independent predictor of better survival in patients with heart failure but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence in the cardiovascular system.

    Hypothesis: Sex and previous gestations might have a prognostic impact on one-year mortality in patients admitted with heart failure. Read More

    Mortality in sepsis: Comparison of outcomes between patients with demand ischemia, acute myocardial infarction and neither demand ischemia nor acute myocardial infarction.
    Clin Cardiol 2018 May 18. Epub 2018 May 18.
    Department of Cardiology, Lehigh Valley Hospital Network, Allentown, PA.
    Introduction: Elevation in cardiac troponins is common among septic patients. We sought to explore outcomes among those admitted with demand ischemia(DI), acute myocardial infarction(AMI) and neither DI nor AMI in sepsis.

    Methods: We analyzed data from the 2011-2014 National Inpatient Sample among patients admitted for sepsis. Read More

    QTc interval in Takotsubo cardiomyopathy: how the activation of insular cortex interact?
    Clin Cardiol 2018 May 15. Epub 2018 May 15.
    Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.
    We read the interesting review article by Marafioti et al., who reported that the association of prolonged QTc interval with Takotsubo cardiomyopathy (Tc) in relation to the right insular cortex (Ic) activity. Several points should be taken into account when interpreting the theory presented by Marafioti et al. Read More

    Recurrence rate of atrial fibrillation after the first clinical episode: A prospective evaluation using continuous cardiac rhythm monitoring.
    Clin Cardiol 2018 May 14;41(5):594-600. Epub 2018 May 14.
    Department of Cardiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece.
    Background: Decision making regarding a patient who has experienced a first clinical episode of atrial fibrillation (AF) is challenging, and the AF recurrences should be a significant consideration. Continuous long-term rhythm monitoring via implantable loop recorders (ILRs) has enabled us to evaluate the AF recurrence profile after the first clinical episode and to investigate clinical parameters associated with the course of the arrhythmia.

    Hypothesis: Continuous rhythm monitoring via ILRs in AF patients after the first clinical episode is of clinical significance and precisely evaluate the AF recurrence profile. Read More

    Relation between age and carotid artery intima-medial thickness: a systematic review.
    Clin Cardiol 2018 May 12;41(5):698-704. Epub 2018 May 12.
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
    Carotid artery intima-medial thickness (cIMT) represents a popular measure of atherosclerosis and is predictive of future cardiovascular and cerebrovascular events. Although older age is associated with a higher cIMT, little is known about whether this increase in cIMT follows a linear relationship with age or it is affected under influence of cardiovascular diseases (CVD) or CVD risk factors. We hypothesize that the relationship between cIMT and age is nonlinear and is affected by CVD or risk factors. Read More

    Absence of a primary role for TTN missense variants in arrhythmogenic cardiomyopathy: From a clinical and pathological perspective.
    Clin Cardiol 2018 May 11;41(5):615-622. Epub 2018 May 11.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: Arrhythmogenic cardiomyopathy (ACM) is an inheritable heart disease characterized by fibro-fatty replacement of the myocardium. TTN missense variants were previously reported as a pathogenic factor for ACM.

    Hypothesis: TTN missense variants are commonly identified in ACM, but have limited effect on the phenotype of ACM. Read More

    The short- and long-term outcomes of percutaneous intervention with drug-eluting stent vs bare-metal stent in saphenous vein graft disease: An updated meta-analysis of all randomized clinical trials.
    Clin Cardiol 2018 May 11;41(5):685-692. Epub 2018 May 11.
    Department of Internal Medicine, Hurley Medical Center/Michigan State University, Flint, Michigan.
    The use of drug-eluting stents (DES) vs bare-metal stents (BMS) in saphenous vein graft (SVG) lesions remains controversial. We conducted a meta-analysis of all randomized clinical trials comparing the outcomes of DES with BMS in SVG percutaneous coronary interventions. A search of PubMed, Embase, the Cochrane Register of Controlled Trials, and Clinicaltrials. Read More

    Peripartum cardiomyopathy: A systematic review of the literature.
    Clin Cardiol 2018 May 11;41(5):693-697. Epub 2018 May 11.
    Tarun W. Dasari, Assistant Professor of Medicine, Cardiovascular Disease Section, University of Oklahoma Health Sciences Center, Oklahoma City.
    Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure. It is defined as cardiomyopathy that develops in the last month of pregnancy or within 5 months of the postpartum period without an identifiable cause. We conducted a systematic review of literature of prospective studies with a focus on echocardiographic and long-term clinical outcomes in PPCM. Read More

    Understanding Patient Adherence and Concerns with STatins and MedicatION Discussions With Physicians (ACTION): A survey on the patient perspective of dialogue with healthcare providers regarding statin therapy.
    Clin Cardiol 2018 May 10. Epub 2018 May 10.
    Utah Lipid Center, Salt Lake City.
    Background: Statins are first-line for cholesterol lowering and prevention of atherosclerotic cardiovascular disease (ASCVD), but their use is complicated by side effects and potential for drug-drug interactions. Provider-patient communication is the basis of the recommended shared decision-making, but relatively little is known about this in the context of statin use.

    Methods: We surveyed 5014 US adults prescribed a statin for hypercholesterolemia to learn their perspectives on communication with their provider. Read More

    The art of cardiovascular risk assessment.
    Clin Cardiol 2018 May 10;41(5):677-684. Epub 2018 May 10.
    Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
    Cardiovascular disease (CVD) remains the leading cause of death in the United States. Healthcare expenditures have been principally allocated toward treatment of CVD at the end of the health/disease continuum, rather than toward health promotion and disease prevention. A focused effort on both primordial and primary prevention can promote cardiovascular health and reduce the burden of CVD. Read More

    Pericarditis among giant cell arteritis patients: From myth to reality.
    Clin Cardiol 2018 May 10;41(5):623-627. Epub 2018 May 10.
    Department of Medicine B and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
    Background: Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Read More

    How do anticoagulated atrial fibrillation patients who suffer ischemic stroke or spontaneous intracerebral hemorrhage differ?
    Clin Cardiol 2018 May 10;41(5):608-614. Epub 2018 May 10.
    Department of Medicine, Keski-Suomi Central Hospital, Jyvaskyla, Finland.
    Background: Atrial fibrillation (AF) increases risk of ischemic stroke, and oral anticoagulation (OAC) increases risk of intracerebral hemorrhage (ICH). This study aimed to compare OAC-treated AF patients with an ischemic stroke/transient ischemic attack (TIA) or spontaneous ICH as their first lifetime cerebrovascular event, especially focusing on patients with therapeutic international normalized ratio (INR).

    Hypothesis: We assumed that in AF patients suffering ischemic stroke/TIA or ICH, patient characteristics could be different in patients with therapeutic INR than in patients with warfarin. Read More

    Trends, etiologies, and predictors of 90-day readmission after percutaneous ventricular assist device implantation: A national population-based cohort study.
    Clin Cardiol 2018 May 10;41(5):561-568. Epub 2018 May 10.
    Department of Cardiovascular Diseases, Einstein Medical Center, Philadelphia, Pennsylvania.
    Percutaneous ventricular assist devices (pVADs) are indicated to provide hemodynamic support in high-risk percutaneous interventions and cardiogenic shock. However, there is a paucity of published data regarding the etiologies and predictors of 90-day readmissions following pVAD use. We studied the data from the US Nationwide Readmissions Database (NRD) for the years 2013 and 2014. Read More

    The prevalence of obstructive sleep apnea in patients with atrial fibrillation.
    Clin Cardiol 2018 May 10;41(5):601-607. Epub 2018 May 10.
    Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario.
    Background: Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play a role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine the prevalence and clinical predictors of OSA in patients with AF. Read More

    Etiologies, predictors and economic impact of readmission within one-month among patients with takotsubo cardiomyopathy.
    Clin Cardiol 2018 May 3. Epub 2018 May 3.
    Department of Cardiology, Albert Einstein Medical Center, Philadelphia, PA.
    Background: Limited data exists on readmission among patients with takotsubo cardiomyopathy [TC], a commonly reversible cause of heart failure. We sought to identify etiologies and predictors for readmission among TC patients.

    Methods: We queried the National Readmissions Database for 2013-2014 to identify patients with primary admission for TC using ICD-9CM code 429. Read More

    Effect of comprehensive remote ischemic conditioning in anterior ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Design and rationale of the CORIC-MI randomized trial.
    Clin Cardiol 2018 May 3. Epub 2018 May 3.
    Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
    Background: Remote ischemic conditioning (RIC) applied during or after an ST-segment elevation myocardial infarction (STEMI) is currently the most promising adjuvant therapy to reduce reperfusion injury. Recent animal studies showed that RIC may help the myocardium recover if applied daily during the month after an STEMI.

    Methods: The CORIC-MI trial is a single-center, randomized controlled study. Read More

    Impact of Delirium on Patients Hospitalized for Myocardial Infarction: a Propensity Score Analysis of The National Inpatient Sample.
    Clin Cardiol 2018 May 1. Epub 2018 May 1.
    Department of Medicine - Rochester Regional Health, Unity Hospital, Rochester, NY.
    Background: Delirium is associated with worse outcomes in critically ill patients. In the subset of patients with myocardial infarction (MI), the impact on clinical outcomes of delirium is not as well elucidated.

    Hypothesis: Delirium is associated with increased mortality in patients hospitalized for MI METHODS: The study used data from the National Inpatient Sample (NIS) 2012 - 2014, Healthcare Cost and Utilization Project (HCUP). Read More

    Long-term results of combined cardiac contractility modulation and subcutaneous defibrillator therapy in patients with heart failure and reduced ejection fraction.
    Clin Cardiol 2018 Apr 26;41(4):518-524. Epub 2018 Apr 26.
    First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
    Background: Cardiac contractility modulation (CCM) is an electrical-device therapy for patients with heart failure with reduced ejection fraction (HFrEF). Patients with left ventricular ejection fraction (LVEF) ≤35% also have indication for an implantable cardioverter-defibrillator (ICD), and in some cases subcutaneous ICD (S-ICD) is selected.

    Hypothesis: CCM and S-ICD can be combined to work efficaciously and safely. Read More

    Etiologies and predictors of 30-day readmissions in patients undergoing percutaneous mechanical circulatory support-assisted percutaneous coronary intervention in the United States: Insights from the Nationwide Readmissions Database.
    Clin Cardiol 2018 Apr 26;41(4):450-457. Epub 2018 Apr 26.
    Rhode Island Hospital, Brown Medical School, Rhode, Providence, Island.
    Background: Patients undergoing percutaneous mechanical circulatory support (pMCS)-assisted percutaneous coronary intervention (PCI) represent a high-risk group vulnerable to complications and readmissions.

    Hypothesis: Thirty-day readmissions after pMCS-assisted PCI are common among patients with comorbidities and account for a significant amount of healthcare spending.

    Methods: Patients undergoing PCI and pMCS (Impella, TandemHeart, or intra-aortic balloon pump) for any indication between January 1, 2012, and November 30, 2014, were selected from the Nationwide Readmissions Database. Read More

    Atrial fibrillation patient preferences for oral anticoagulation and stroke knowledge: Results of a conjoint analysis.
    Clin Cardiol 2018 Apr 25. Epub 2018 Apr 25.
    Institute of Cardiovascular Sciences, University of Birmingham, UK.
    Background: Guidelines recommend that patients with atrial fibrillation (AF) are involved in oral anticoagulant (OAC) treatment decisions. Understanding which OAC attributes AF patients value most could help optimize treatment.

    Objective: To assess the relationship between patient's stroke knowledge and their preferences for specific OAC attributes. Read More

    Left ventricular end-diastolic volume predicts exercise capacity in patients with a normal ejection fraction.
    Clin Cardiol 2018 May 25;41(5):628-633. Epub 2018 Apr 25.
    Department of Medicine, Cardiology Division, Larner College of Medicine, University of Vermont, Burlington.
    Background: Exercise capacity is a powerful predictor of all-cause mortality. The duration of exercise with treadmill stress testing is an important prognostic marker in both healthy subjects and patients with cardiovascular disease. Left ventricular (LV) structure is known to adapt to sustained changes in level of physical activity. Read More

    CHA DS -VASc score and clinical outcomes of patients with chest pain discharged from internal medicine wards following acute coronary syndrome rule-out.
    Clin Cardiol 2018 Apr 23;41(4):539-543. Epub 2018 Apr 23.
    Department of Internal Medicine C, Meir Medical Center, Kfar Saba, Israel.
    Background: Chest-pain patients deemed safe for discharge from internal medicine wards might still be at risk for adverse outcomes.

    Hypothesis: CHA DS -VASc score improves risk stratification of low-risk chest-pain patients discharged after acute coronary syndrome (ACS) rule-out.

    Methods: We accessed medical records of patients who were admitted to internal medicine wards at a single medical center during 2010-2016 and discharged following an ACS rule-out. Read More

    Increased left atrial size is associated with higher atrial fibrillation recurrence in patients treated with antiarrhythmic medications.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    UPMC Heart and Vascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
    Background: Atrial fibrillation (AF) is highly prevalent, and antiarrhythmic therapy is often used to help with rhythm control. Some common echocardiographic parameters may be useful in predicting AF recurrence among these patients. The purpose of this study was to evaluate the association between 3 common echocardiographic parameters (left atrial [LA] size, left ventricular ejection fraction [LVEF], and mitral regurgitation [MR]) and AF recurrence among patients treated with antiarrhythmic medications. Read More

    Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction.
    Clin Cardiol 2018 Apr 19;41(4):488-493. Epub 2018 Apr 19.
    Division of Cardiology, Department of Internal Medicine, University of Kentucky, Lexington.
    Background: Studies have reported sex differences in the management of patients with acute myocardial infarction (AMI) in the general population. This observational study is designed to evaluate whether sex differences exist in the contemporary management of human immunodeficiency virus (HIV) patients admitted for diagnosis of AMI.

    Hypothesis: There is no difference in management of HIV patients with AMI. Read More

    Whole-exome sequencing reveals microsatellite DNA markers for response to dofetilide initiation in patients with persistent atrial fibrillation: A pilot study.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
    Background: Dofetilide is a class III antiarrhythmic drug effective for the treatment of atrial fibrillation (AF). Dofetilide initiation (DI) associates with corrected QT interval (QTc) prolongation. Significant QTc prolongation during DI mandates dose adjustment or discontinuation of the drug. Read More

    Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    Department of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
    Background: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined.

    Hypothesis: Low serum androgens are associated with an increased risk of AF.

    Methods: We examined the prospective associations between testosterone, its more active metabolite dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) with risk of AF among 1019 otherwise healthy men with average age 76. Read More

    Electrocardiography scar quantification correlates with scar size of hypertrophic cardiomyopathy seen by multidetector computed tomography.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    Institute of Cardiology Dante Pazzanese, São Paulo, Brazil.
    Background: Hypertrophic cardiomyopathy (HCM), a genetically transmitted disease, is the most common genetic cardiovascular disease. Current strategies to stratify risk are expensive and concentrated in wealthy centers. Twelve-lead electrocardiography (ECG) is inexpensive, universally available, and can be readily used for Selvester QRS scoring, which estimates scar size. Read More

    Harnessing mHealth technologies to increase physical activity and prevent cardiovascular disease.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD.
    Cardiovascular prevention research has increasingly focused on mobile health (mHealth) technologies and their efficacy in helping individuals adhere to heart-healthy recommendations, including daily physical activity levels. By including the use of mHealth technologies in the discussion of physical activity recommendations, clinicians empower patients to play an active daily role in modifying their cardiovascular risk factor profile. In this review, we critically evaluate the mHealth and physical activity literature to determine how these tools may lower cardiovascular risk while providing real-time tracking, feedback and motivation on physical activity levels. Read More

    Atrial remodeling and ectopic burden in recreational athletes: Implications for risk of atrial fibrillation.
    Clin Cardiol 2018 Apr 19. Epub 2018 Apr 19.
    Centre for Heart Rhythm Disorders, South Australian Health & Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
    Background: Atrial remodeling, vagal tone, and atrial ectopic triggers are suggested to contribute to increased incidence of atrial fibrillation (AF) in endurance athletes. How these parameters change with increased lifetime training hours is debated.

    Hypothesis: Atrial remodeling occurs in proportion to total training history, thus contributing to elevated risk of AF. Read More

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