6,370 results match your criteria Clinical cardiology[Journal]


Electrocardiographic modifications induced by breast implants.

Clin Cardiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology, Princess Grace Hospital, Monaco (Principality).

Background: Echocardiography realization can be challenging in the presence of breasts implants (BI). It is less known if electrocardiograms (ECG) may be modified in the presence of BI.

Methods: ECG from women with BI (and without any known cardiac structural disease) were sent and analyzed by two experienced electrophysiologists (EP1 and EP2) who were blinded and completely unaware of the context of the patients (Group 1). Read More

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http://dx.doi.org/10.1002/clc.23174DOI Listing

Stroke prevention in patients from Latin American countries with non-valvular atrial fibrillation: Insights from the GARFIELD-AF registry.

Clin Cardiol 2019 Mar 15. Epub 2019 Mar 15.

Thrombosis Research Institute, London, United Kingdom.

Background: Atrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular atrial fibrillation (NVAF) from Latin American countries are poorly described. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23176
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http://dx.doi.org/10.1002/clc.23176DOI Listing
March 2019
1 Read

Prediction of Spontaneous closure of ventricular septal defect and guidance for clinical Follow-up.

Clin Cardiol 2019 Mar 9. Epub 2019 Mar 9.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.

Aim: To predict the spontaneous closure of ventricular septal defect (VSD) and assist pediatrician to manage VSD children.

Methods: Between January 2008 and December 2016, 145 children diagnosed with isolated VSD by echocardiography were enrolled. All participating children were followed-up by echocardiography yearly until the closure of VSD or 6 years old. Read More

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http://dx.doi.org/10.1002/clc.23173DOI Listing
March 2019
1 Read

Titin-truncating Variants Are Associated with Heart Failure Events in Patients with Left Ventricular Noncompaction Cardiomyopathy.

Clin Cardiol 2019 Mar 9. Epub 2019 Mar 9.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Titin-truncating variants (TTNtv) have been recognized as the most prevalent genetic cause of dilated cardiomyopathy. However, their effects on phenotypes of left ventricular noncompaction cardiomyopathy (LVNC) remain largely unknown.

Hypothesis: The presence of TTNtv may have an effect on the phenotype of LVNC. Read More

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http://doi.wiley.com/10.1002/clc.23172
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http://dx.doi.org/10.1002/clc.23172DOI Listing
March 2019
2 Reads

Electrocardiographic Findings in Peripartum Cardiomyopathy.

Clin Cardiol 2019 Mar 7. Epub 2019 Mar 7.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background: There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes.

Hypothesis: We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes. Read More

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http://dx.doi.org/10.1002/clc.23171DOI Listing
March 2019
4 Reads

Effective combination of isolated symptom variables to help stratifying acute undifferentiated chest pain in the emergency department.

Clin Cardiol 2019 Mar 4. Epub 2019 Mar 4.

Department of Emergency and Chest Pain Center, Qilu Hospital, Shandong University, Jinan, China.

Background: Symptom is still indispensable for stratification of chest pain in the emergency department (ED). However, it is a sophisticated aggregation of several aspects of characteristics and effective combination of those variables remains deficient. We aimed to develop and validate a chest pain symptom score (CPSS) to address this issue. Read More

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http://dx.doi.org/10.1002/clc.23170DOI Listing

Experience of extracorporeal cardiopulmonary resuscitation in a refractory cardiac arrest patient at the emergency department.

Clin Cardiol 2019 Feb 28. Epub 2019 Feb 28.

Department of Emergency Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.

Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is a method to improve survival outcomes in refractory cardiac arrest.

Hypothesis: This study aimed to determine the associated factors related to outcome and to analyse the post-ECPR management in patients who received ECPR due to non-response to advanced cardiac life support (ACLS).

Methods: This was a retrospective analysis based on a prospective cohort. Read More

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http://dx.doi.org/10.1002/clc.23169DOI Listing
February 2019
1 Read

Patients and informal caregivers' experience of surgical and transcatheter aortic valve replacement: Real-world data contributing to establish value-based medicine in Denmark.

Clin Cardiol 2019 Feb 28. Epub 2019 Feb 28.

The Heart Center, Rigshospitalet, Copenhagen, Denmark.

Background: The concept of value-based medicine (VBM) is increasingly implemented in therapeutic decision-making processes, but only few data on patient-perceived values are available in the field of aortic stenosis treatment.

Hypothesis: This study aimed to deliver data on patient-perceived values and health-related quality of life (HR-QoL) following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) in a real-world, all-comers patient population.

Methods: Questionnaires were sent to 637 patients who had undergone elective AVR 12 to 24 months earlier in the period September 2015 to August 2016. Read More

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http://dx.doi.org/10.1002/clc.23166DOI Listing
February 2019

Management of cardiogenic shock complicating acute myocardial infarction: A review.

Clin Cardiol 2019 Feb 26. Epub 2019 Feb 26.

Cleveland Clinic Foundation, Cleveland, OH, USA.

Despite advances in percutaneous coronary interventions and their widespread use, mortality in patients presenting with acute myocardial infarction complicated by cardiogenic shock has remained very high, and treatment options are limited. Limited evidences exist, supporting many of the routinely used therapies in treating these patients. In the present article, we discuss cardiogenic shock complicating myocardial infarction in general and an update on the currently available treatment options, including inotropes and vasopressor, coronary revascularization, mechanical circulatory support devices, mechanical complications and long-term outcomes. Read More

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http://dx.doi.org/10.1002/clc.23168DOI Listing
February 2019
1 Read

Increasing incidence of IV-drug use associated endocarditis in southern West Virginia and potential economic impact.

Clin Cardiol 2019 Feb 25. Epub 2019 Feb 25.

Charleston Area Medical Center, 3200 MacCorkle Avenue SE, Charleston, West Virginia.

Background: The opioid crisis has disproportionally affected Appalachia. One of the potentially lethal and costly complications associated with IV drug use is infective endocarditis (IE). The goal of this study was to assess the trend and costs of substance abuse associated IE admissions in Southern West Virginia. Read More

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http://dx.doi.org/10.1002/clc.23162DOI Listing
February 2019
1 Read

Atrioventricular block can be used as a risk predictor of clinical atrial fibrillation.

Clin Cardiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Rehabilitation and Treatment, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, CHINA.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with its incidence making up nearly one third of all hospital admissions . Atrioventricular block (AVB) is a conduction abnormality along the atrioventricular node or the His-Purkinje system. The relationship between atrioventricular conduction block and atrial fibrillation is controversial. Read More

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http://dx.doi.org/10.1002/clc.23167DOI Listing
February 2019
2 Reads

Emerging Misunderstood Presentations of Cardiovascular Disease in Young Women.

Clin Cardiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiology, University of Arizona College of Medicine- Phoenix.

Background: Cardiovascular disease (CVD) remains the leading cause of death for females in the United States accounting for over 412,000 female deaths in 2016. CVD mortality in young women <55 years old remains significantly high and greater than that in men.

Hypothesis: There is a void with regards to awareness of CVD in women. Read More

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http://dx.doi.org/10.1002/clc.23165DOI Listing
February 2019

Rationale, Design, and Baseline Characteristics of THEMIS: Effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study.

Clin Cardiol 2019 Feb 20. Epub 2019 Feb 20.

FACT (French Alliance for Cardiovascular Trials), an F-CRIN network, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Université Paris-Diderot, INSERM U-1148, Paris, France.

In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor versus placebo, on top of low dose aspirin. Read More

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http://dx.doi.org/10.1002/clc.23164DOI Listing
February 2019

Pulmonary vein anatomy addressed by computed tomography and relation to success of second-generation cryoballoon ablation in paroxysmal atrial fibrillation.

Clin Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Cryoballoon isolation is considered a safe and effective treatment for atrial fibrillation (AF). However, recurrence of AF after first cryoballoon ablation occurs in ~30% of patients. Pre-procedurally identifying patients at risk of AF recurrence could be beneficial. Read More

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http://dx.doi.org/10.1002/clc.23163DOI Listing
February 2019

Underpowered observational studies create confusion regarding clinical impact of surgical interventions.

Clin Cardiol 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

We thank Dr Gupta et al for their interest in our manuscript. We certainly agree with their comments regarding the potential limitations of our single-center, observational analysis and have acknowledged these in the limitations section. Read More

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http://dx.doi.org/10.1002/clc.23157DOI Listing
February 2019

The rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary disease.

Clin Cardiol 2019 Mar 25;42(3):346-351. Epub 2019 Feb 25.

Divisions of Pulmonary and Critical Care Medicine and General Medical Sciences, Washington University School of Medicine, St. Louis, Missouri.

Introduction: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalized because of ECOPD.

Methods: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, and parallel-group trial. Read More

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http://dx.doi.org/10.1002/clc.23161DOI Listing
March 2019
6 Reads

Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: A Meta-analysis of Prospective Studies.

Clin Cardiol 2019 Jan 29. Epub 2019 Jan 29.

Department of Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Aim: Previous studies have documented that the association between growth differentiation factor-15(GDF-15) the risk of patients with cardiovascular diseases. In this meta-analysis, our main objective is to explore the associations between growth differentiation factor-15 and the risk of cardiovascular diseases (CVD) or all-cause mortality.

Methods: PubMed and ISI Web of Science (up to January 2018) electronic databases were browsed for eligible studies. Read More

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http://dx.doi.org/10.1002/clc.23159DOI Listing
January 2019

Cardiovascular events and death after myocardial infarction or ischemic stroke in an older Medicare population.

Clin Cardiol 2019 Mar 25;42(3):391-399. Epub 2019 Feb 25.

Metabolic Institute of America, Endocrinology, Tarzana, California.

Background: Survivors of myocardial infarction (MI) or ischemic stroke (IS) are at high risk for subsequent cardiovascular events.

Hypothesis: Older patients with prior MI or IS are at risk for recurrent cardiovascular events, and comorbidities such as diabetes may increase this risk.

Methods: Two cohorts were studied in a retrospective Medicare 20% random sample-a 2008 cohort with up to 6 years of follow-up (MI, N = 26 460; IS, N = 17 566) and a 2012 cohort with 1 year of follow-up (MI, N = 26 548; IS, N = 17 728). Read More

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http://dx.doi.org/10.1002/clc.23160DOI Listing

Altered profile of circulating microparticles in nonvalvular atrial fibrillation.

Clin Cardiol 2019 Jan 25. Epub 2019 Jan 25.

Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Nonvalvular atrial fibrillation (AF) is the most common cardiac arrhythmia, and it is associated with the prothrombotic state. Circulating microparticles (cMPs) are membrane vesicles that are shed from many cell types in response to cell activation and cell apoptosis. Several studies reported that cMPs may play a role in the hypercoagulable state that can be observed in patients with AF. Read More

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http://doi.wiley.com/10.1002/clc.23158
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http://dx.doi.org/10.1002/clc.23158DOI Listing
January 2019
5 Reads

Comparisons of efficacy, safety, and recurrence risk factors of paroxysmal and persistent atrial fibrillation catheter ablation using robotic magnetic navigation system.

Clin Cardiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Cardiology, The First Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.

Background: No data exist on comparisons of efficacy, safety, and recurrence risk factors of paroxysmal and persistent atrial fibrillation (AF) ablation using robotic magnetic navigation system (MNS), respectively.

Methods: About 151 AF patients were prospectively enrolled and divided into paroxysmal AF group (n = 102) and persistent AF group (n = 49). Circumferential pulmonary vein antrum isolation (CPVI) was performed in all patients. Read More

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http://doi.wiley.com/10.1002/clc.23156
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http://dx.doi.org/10.1002/clc.23156DOI Listing
January 2019
13 Reads

Association of obesity phenotypes with electrocardiographic subclinical myocardial injury in the general population.

Clin Cardiol 2019 Mar 6;42(3):373-378. Epub 2019 Feb 6.

Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Background: As the debate continues about whether obesity in metabolically healthy individuals is associated with poor outcomes or not, investigating the association between the obesity phenotypes and markers of subclinical myocardial injury will help identify those at risk for future cardiovascular events (cardiovascular disease [CVD]).

Hypothesis: We hypothesize that obesity phenotypes including metabolically healthy obesity (MHO) is associated with subclinical myocardial injury (SC-MI).

Methods: This analysis included 3423 participants (57. Read More

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http://dx.doi.org/10.1002/clc.23155DOI Listing
March 2019
2 Reads
2.225 Impact Factor

Underpowered observational studies create confusion regarding clinical impact of surgical interventions.

Clin Cardiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/clc.23149DOI Listing
January 2019
1 Read

Catheter ablation of atrial fibrillation-A key role in heart failure therapy?

Clin Cardiol 2019 Mar 12;42(3):400-405. Epub 2019 Feb 12.

II. Medizinische Klinik, Kardiologie, Angiologie, Pneumologie, Klinikum Coburg, Coburg, Germany.

Atrial fibrillation (AF) and heart failure (HF) are epidemic cardiac diseases and are often detected in the same patient. Recent evidence suggests that this is not a mere coincidence but that the strategy of AF treatment may impact HF development. This review comprehensively summarizes current trial data on rhythm and rate control strategies in atrial fibrillation with a special focus on catheter ablation of AF in HF patients. Read More

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http://dx.doi.org/10.1002/clc.23150DOI Listing
March 2019
2 Reads

Prevalence of familial hypercholesterolemia in patients with premature myocardial infarction.

Clin Cardiol 2019 Mar 19;42(3):385-390. Epub 2019 Feb 19.

Department of Cardiology, Peking University People's Hospital, Beijing, China.

Background: Familial hypercholesterolemia (FH) is a genetic cause of premature myocardial infarction (PMI). Early diagnosis of FH is critical for prognosis.

Hypothesis: To investigate the prevalence of FH among a cohort of Chinese patients with PMI using genetic testing, and to evaluate different diagnostic criteria. Read More

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http://doi.wiley.com/10.1002/clc.23154
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http://dx.doi.org/10.1002/clc.23154DOI Listing
March 2019
11 Reads

Low serum albumin: A significant predictor of reduced survival in patients with chronic heart failure.

Clin Cardiol 2019 Mar 7;42(3):365-372. Epub 2019 Feb 7.

Heart Institute, Hadassah University Hospital, Jerusalem, Israel.

Background: Low serum albumin is common in patients with chronic heart failure (HF).

Hypothesis: Albumin may have an impact on clinical outcome in HF. We evaluated the effect of albumin levels on clinical outcome in a real-world cohort of patients with HF. Read More

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http://dx.doi.org/10.1002/clc.23153DOI Listing
March 2019
3 Reads

The effect of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 agonists on cardiovascular disease in patients with type 2 diabetes.

Clin Cardiol 2019 Mar 6;42(3):406-412. Epub 2019 Feb 6.

Division of Pediatric Endocrinology, Georgetown University, Washington, District of Columbia.

Patients with type 2 diabetes have a significantly increased risk of cardiovascular disease (CVD) compared to the general population-with CVD accounting for two out of every three deaths in patients with diabetes. In 2008, the FDA suggested that CVD risk should be evaluated for any new antidiabetic therapy, leading to a multitude of large CVD outcome trials to assess CVD risk from these medications. Interestingly, several of these outcome trials with new novel antidiabetic therapies have demonstrated a clear and definite CVD advantage at mid-term follow up in high-risk patients with T2DM. Read More

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http://dx.doi.org/10.1002/clc.23152DOI Listing
March 2019
1 Read

Pulmonary vascular resistance index: Getting the units right and why it matters.

Clin Cardiol 2019 Mar 27;42(3):334-338. Epub 2019 Feb 27.

Division of Cardiovascular Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Pulmonary vascular resistance (PVR) and PVR index (PVRI) are key variables in a broad range of contexts, including prediction of outcomes in heart and liver transplantation, determining candidacy for closure of atrial or ventricular septal defects, and guiding treatment of pulmonary hypertension. Significant variability exists among the units used to report PVRI in current literature, making the interpretation of data and translation into clinical practice difficult. Here, we will review the measurement and derivation of PVR and PVRI and demonstrate the extent of confusion in the literature. Read More

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http://doi.wiley.com/10.1002/clc.23151
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http://dx.doi.org/10.1002/clc.23151DOI Listing
March 2019
20 Reads

Predictive value of a fragmented QRS complex in diagnosing patients with myocardial ischemia.

Clin Cardiol 2019 Mar 19;42(3):379-384. Epub 2019 Feb 19.

Department of Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: A fragmented QRS complex (fQRS) is caused by conduction abnormalities of the ventricle secondary to myocardial ischemia and/or scar in patients with myocardial infarction. However, the implications of the fQRS in the development of coronary artery disease with myocardial ischemia in those without a scar remain unknown.

Methods: We studied electrocardiograms (ECGs) obtained from 150 patients (60. Read More

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http://dx.doi.org/10.1002/clc.23148DOI Listing
March 2019
1 Read

Association of acute myocardial infarction cardiac arrest patient volume and in-hospital mortality in the United States: Insights from the National Cardiovascular Data Registry Acute Coronary Treatment And Intervention Outcomes Network Registry.

Clin Cardiol 2019 Mar 7;42(3):352-357. Epub 2019 Feb 7.

Duke Clinical Research Institute, Durham, North Carolina.

Background: Little is known about how differences in out of hospital cardiac arrest patient volume affect in-hospital myocardial infarction (MI) mortality.

Hypothesis: Hospitals accepting cardiac arrest transfers will have increased hospital MI mortality.

Methods: MI patients (ST elevation MI [STEMI] and non-ST elevation MI [NSTEMI]) in the Acute Coronary Treatment Intervention Outcomes Network Registry were included. Read More

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http://dx.doi.org/10.1002/clc.23146DOI Listing
March 2019
6 Reads

CHA2DS2-VASc score predicts atrial fibrillation recurrence after cardioversion: Systematic review and individual patient pooled meta-analysis.

Clin Cardiol 2019 Mar 11;42(3):358-364. Epub 2019 Feb 11.

Cardiovascular Center, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.

Background: Despite progresses in the treatment of the thromboembolic risk related to atrial fibrillation (AF), the management of recurrences remains a challenge.

Hypothesis: To assess if congestive heart failure or left ventricular systolic dysfunction (CHA DS -VASc) score is predictive of early arrhythmia recurrence after AF cardioversion.

Methods: Systematic review and individual patient pooled meta-analysis following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1002/clc.23147DOI Listing
March 2019
1 Read

A comparison of anti-arrhythmic efficacy of carvedilol vs metoprolol succinate in patients with implantable cardioverter-defibrillators.

Clin Cardiol 2019 Feb 14;42(2):299-304. Epub 2019 Jan 14.

Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: The effects of carvedilol and metoprolol succinate on appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy in patients with heart failure with reduced ejection fraction (HFrEF) are not fully understood.

Hypothesis: The hypothesis of our study is possible carvedilol superiority over metoprolol in patients with ICD.

Methods: All patients with ICD registered to a single device clinic between 1/2012 and 6/2017 (n = 569) were identified. Read More

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http://doi.wiley.com/10.1002/clc.23144
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http://dx.doi.org/10.1002/clc.23144DOI Listing
February 2019
3 Reads

Insulin resistance influences the impact of hypertension on left ventricular diastolic dysfunction in a community sample.

Clin Cardiol 2019 Feb 14;42(2):305-311. Epub 2019 Jan 14.

Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Although obesity-associated metabolic abnormalities (insulin resistance-IR) may not play as marked a role in determining left ventricular (LV) diastolic dysfunction (DD) as hypertension, the impact of combinations of these risk factors on DD is unknown.

Hypothesis: We hypothesized that IR influences the impact of hypertension on DD.

Methods: In 704 randomly selected participants from a community sample with a high prevalence of hypertension (50. Read More

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http://doi.wiley.com/10.1002/clc.23145
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http://dx.doi.org/10.1002/clc.23145DOI Listing
February 2019
6 Reads

A clinical, proteomics, and artificial intelligence-driven model to predict acute kidney injury in patients undergoing coronary angiography.

Clin Cardiol 2019 Feb 8;42(2):292-298. Epub 2019 Jan 8.

Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

Background: Standard measures of kidney function are only modestly useful for accurate prediction of risk for acute kidney injury (AKI).

Hypothesis: Clinical and biomarker data can predict AKI more accurately.

Methods: Using Luminex xMAP technology, we measured 109 biomarkers in blood from 889 patients prior to undergoing coronary angiography. Read More

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http://dx.doi.org/10.1002/clc.23143DOI Listing
February 2019
7 Reads

Development of an entirely remote, non-physician led hypertension management program.

Clin Cardiol 2019 Feb 17;42(2):285-291. Epub 2019 Jan 17.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

Background: Hypertension remains poorly controlled on the population level. National rates of control, even when defined leniently by BP < 140/90 mm Hg, are only ~50%. As growing healthcare costs coincide with tighter blood pressure (BP) targets, innovative management programs are needed to maximize efficiency of care delivery and optimize control. Read More

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http://dx.doi.org/10.1002/clc.23141DOI Listing
February 2019
9 Reads

Anticoagulation in patients with atrial fibrillation and heart failure: Insights from the NCDR PINNACLE-AF registry.

Clin Cardiol 2019 Mar 30;42(3):339-345. Epub 2019 Jan 30.

University of Colorado School of Medicine, Division of Cardiology, Aurora, Colorado.

Background: In non-valvular atrial fibrillation (NVAF) patients, congestive heart failure (CHF) confers an increased risk of stroke or systemic thromboembolism. This risk is present in both heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). It is unclear if clinicians account for both types of CHF in their NVAF anticoagulation practices. Read More

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http://dx.doi.org/10.1002/clc.23142DOI Listing
March 2019
1 Read

Ejection fraction, B-type natriuretic peptide and risk of stroke and acute myocardial infarction among patients with heart failure.

Clin Cardiol 2019 Feb 7;42(2):277-284. Epub 2019 Jan 7.

Department of Medicine, Ronald Reagan-UCLA Medical Center, Los Angeles, California.

Background: Real-world data on the clinical outcomes of heart failure (HF) across the spectrum of ejection fraction (EF) and the prognostic value of B-type natriuretic peptide (BNP) have not been well examined.

Hypothesis: The real-world association between the clinical outcomes of HF and EF or BNP levels may differ across different EF or BNP values.

Methods: The Optum Integrated Claims-Clinical data (07/2009-09/2016) was used to identify adult patients with ≥1 HF diagnosis during hospitalization or emergency room visit. Read More

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http://doi.wiley.com/10.1002/clc.23140
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http://dx.doi.org/10.1002/clc.23140DOI Listing
February 2019
6 Reads
2.225 Impact Factor

Clinical scores used for the prediction of negative events in patients undergoing catheter ablation for atrial fibrillation.

Clin Cardiol 2019 Feb 14;42(2):320-329. Epub 2019 Jan 14.

Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adults. Catheter ablation (CA) is one of the most important management strategies to reduce AF burden and AF-associated complications. In order to stratify the risk of adverse events and to predict treatment success in AF patients undergoing CA, several risk stratification scores had been developed during the last decade. Read More

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http://doi.wiley.com/10.1002/clc.23139
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http://dx.doi.org/10.1002/clc.23139DOI Listing
February 2019
9 Reads

Thrombo-embolic complications in takotsubo syndrome: Review and demonstration of an illustrative case.

Clin Cardiol 2019 Feb 3;42(2):312-319. Epub 2019 Jan 3.

Coronary Artery Disease Area, Heart and Vascular Theme, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Thrombo-embolism is one of the serious complications of takotsubo syndrome (TS) in addition to heart failure, pulmonary edema, cardiogenic shock, cardiac arrest, life-threatening arrhythmias, left ventricular outlet tract obstruction, mitral regurgitation, cardiac rupture, and death. The most common cardio-embolic events in TS are cerebral, renal, and peripheral embolism. Approximately, one-third of patients with left ventricular thrombus (LVT) in TS develop embolic complications. Read More

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http://dx.doi.org/10.1002/clc.23137DOI Listing
February 2019
5 Reads

B-type natriuretic peptide is associated with remodeling and exercise capacity after transcatheter aortic valve replacement for aortic stenosis.

Clin Cardiol 2019 Feb 31;42(2):270-276. Epub 2018 Dec 31.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

Background: We aimed to assess longitudinal changes of B-type natriuretic peptide (BNP) in aortic stenosis (AS) patients treated by transcatheter aortic valve replacement (TAVR).

Methods: From our TAVR database, we identified 193 consecutive patients with severe symptomatic AS who underwent TAVR and were prospectively followed using serial BNP levels and echocardiography. Patients were divided into subgroups according to type of left ventricular (LV) remodeling as having normal LV mass and relative wall thickness, or showing concentric remodeling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH). Read More

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http://dx.doi.org/10.1002/clc.23138DOI Listing
February 2019
2 Reads
2.225 Impact Factor

Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes.

Clin Cardiol 2019 Feb 26;42(2):256-263. Epub 2018 Dec 26.

Division of Cardiology, Duke University Hospital, Durham, North Carolina.

Background: When used in appropriately selected heart failure (HF) patients, cardiac resynchronization therapy (CRT) reduces mortality and hospitalization. It is not understood whether CRT implantation during hospitalization for HF is associated with similar benefits.

Hypothesis: Timing of CRT implantation relative to hospitalization for HF is associated with clinical outcomes. Read More

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http://dx.doi.org/10.1002/clc.23135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386168PMC
February 2019
3 Reads
2.225 Impact Factor

Predictors of improvement in arrhythmia-specific symptoms and health-related quality of life after catheter ablation of atrial fibrillation.

Clin Cardiol 2019 Feb 21;42(2):247-255. Epub 2018 Dec 21.

Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: The primary goal of radiofrequency ablation (RFA) of atrial fibrillation (AF) is to improve symptoms and health-related quality of life (HRQoL). However, most studies have focused on predictors of AF recurrence rather than on predictors of improvement in symptoms and HRQoL.

Hypothesis: We sought to explore predictors of improvement in arrhythmia-specific symptoms and HRQoL after RFA of AF, and to evaluate the effects on symptoms, HRQoL, anxiety, and depression. Read More

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http://dx.doi.org/10.1002/clc.23134DOI Listing
February 2019
1 Read

Relation of left atrial appendage closure devices to topographic neighboring structures using standardized imaging by cardiac computed tomography angiography.

Clin Cardiol 2019 Feb 21;42(2):264-269. Epub 2018 Dec 21.

First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research), Mannheim, Germany.

Background: Although left atrial appendage (LAA) anatomy and topographic relations are well understood, little is known about the impairment of neighboring structures (NBS) by an implanted left atrial appendage closure (LAAC) device. This prospective longitudinal observational study for the first time describes distances of implanted LAA closure (LAAC) devices to NBS using a standardized imaging protocol of cardiac computed tomography angiography (cCTA).

Hypothesis: cCTA imaging is an eligible tool for post-implantation evaluation of LAAC devices and their relation to neighboring structures. Read More

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http://dx.doi.org/10.1002/clc.23136DOI Listing
February 2019
7 Reads

Racial and gender disparities among patients with Takotsubo syndrome.

Clin Cardiol 2019 01 14;42(1):19. Epub 2018 Dec 14.

Department of Cardiology, Heartland Regional Medical Center, Marion, Illinois.

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http://dx.doi.org/10.1002/clc.23130DOI Listing
January 2019
1 Read
2.225 Impact Factor

Reply to "racial and gender disparities among patients with Takotsubo syndrome".

Clin Cardiol 2019 01 14;42(1):20. Epub 2018 Dec 14.

Division of Cardiology, University of Kansas Medical Center, Kansas City, Kansas.

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http://dx.doi.org/10.1002/clc.23129DOI Listing
January 2019
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Exercise worsening of electromechanical disturbances: A predictor of arrhythmia in long QT syndrome.

Clin Cardiol 2019 Feb 22;42(2):235-240. Epub 2018 Dec 22.

Institute of Public Health and Clinical Medicine, Umea University, Umea, Sweden.

Background: Electromechanical (EM) coupling heterogeneity is significant in long QT syndrome (LQTS), particularly in symptomatic patients; EM window (EMW) has been proposed as an indicator of interaction and a better predictor of arrhythmia than QTc.

Hypothesis: To investigate the dynamic response of EMW to exercise in LQTS and its predictive value of arrhythmia.

Methods: Forty-seven LQTS carriers (45 ± 15 years, 20 with arrhythmic events), and 35 controls underwent exercise echocardiogram. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23132
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http://dx.doi.org/10.1002/clc.23132DOI Listing
February 2019
15 Reads

Comparison of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation.

Clin Cardiol 2019 Feb 20;42(2):241-246. Epub 2018 Dec 20.

Department of Medicine, University of Ulsan College of Medicine, Seoul, South Korea.

Background: The renin-angiotensin system plays an important role in promoting atherosclerotic plaque inflammation, which may be inhibited by angiotension-II receptor blockers.

Hypothesis: We investigated the effects of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation using F-fluorodeoxyglucose ( FDG) positron emission tomography (PET) imaging.

Methods: Fifty patients with acute coronary syndrome (ACS) and at least one lesion with FDG uptake in the carotid artery (target-to-background ratio [TBR] ≥ 1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.23133
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http://dx.doi.org/10.1002/clc.23133DOI Listing
February 2019
6 Reads
2.225 Impact Factor

High-sensitivity cardiac troponin T as a predictor of acute Total occlusion in patients with non-ST-segment elevation acute coronary syndrome.

Clin Cardiol 2019 Feb 21;42(2):222-226. Epub 2018 Dec 21.

Cardiology Department, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Background: A large percentage of patients with non-ST-segment acute coronary syndrome (NSTE-ACS) present with acute total occlusion (TO) of some major epicardial vessel that does not generate electrocardiographic changes. Ongoing research into the methods of accurately predicting acute TO have not yielded great success.

Hypothesis: High-sensitivity cardiac troponin T (hs-cTnT) has a good predictive value for the presence of acute TO of the culprit artery in patients with NSTE-ACS. Read More

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http://dx.doi.org/10.1002/clc.23128DOI Listing
February 2019
3 Reads

Atherothrombotic risk stratification after acute myocardial infarction: The Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention in the light of the French Registry of Acute ST Elevation or non-ST Elevation Myocardial Infarction registries.

Clin Cardiol 2019 Feb 27;42(2):227-234. Epub 2018 Dec 27.

Department of Cardiology, Hôpital Européen Georges Pompidou (HEGP), Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Background: Guidelines recommend using risk stratification tools in acute myocardial infarction (AMI) to assist decision-making. The Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention (TRS-2P) has been recently developed to characterize long-term risk in patients with MI.

Hypothesis: We aimed to assess the TRS-2P in the French Registry of Acute ST Elevation or non-ST elevation MI registries. Read More

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http://dx.doi.org/10.1002/clc.23131DOI Listing
February 2019
4 Reads

Alcohol and ideal cardiovascular health: The Multi-Ethnic Study of Atherosclerosis.

Clin Cardiol 2019 Jan 17;42(1):151-158. Epub 2018 Dec 17.

The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, Maryland.

Background: Alcohol consumption is associated with cardiovascular disease (CVD), with moderate drinkers having decreased CVD risk compared to non- and heavy drinkers. However, whether alcohol consumption is associated with ideal cardiovascular health (CVH), assessed by the American Heart Association's (AHA) Life's Simple 7 (LS7) metrics, and whether associations differ by sex, is uncertain.

Hypothesis: Heavy alcohol consumption is associated with worse CVH. Read More

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http://dx.doi.org/10.1002/clc.23125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357768PMC
January 2019
3 Reads

Comment on "Transcatheter aortic valve replacement in patients with pure native aortic valve regurgitation: A systematic review and meta-analysis".

Clin Cardiol 2019 01 21;42(1):167-168. Epub 2018 Dec 21.

Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

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http://dx.doi.org/10.1002/clc.23127DOI Listing
January 2019
2 Reads