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    6078 results match your criteria Clinical cardiology[Journal]

    1 OF 122

    Effect of type D personality on smoking status and their combined impact on outcome after acute myocardial infarction.
    Clin Cardiol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Clinical and Experimental Medicine, University of Messina, Italy.
    Background: Smoking cessation is correlated with several psychological, social, biological, and pharmacological aspects. The combined tendency to experience negative emotions and to inhibit the expression of these emotions is indicated as "type D personality," an independent risk marker for clinical outcome in cardiac disease. Despite this effect of type D personality on cardiovascular disease, it is still unclear whether this personality trait may influence smoking cessation after a myocardial infarction. Read More

    Peripartum cardiomyopathy: Status 2018.
    Clin Cardiol 2018 Feb 16. Epub 2018 Feb 16.
    Division of Cardiology, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, Georgia.
    Peripartum cardiomyopathy is a rare cardiac condition, overall. However, in certain populations can be found frequently enough and the signs, symptoms, and management should be readily understood. Here we provide an updated overview of this topic. Read More

    The connection between the breast and heart in a woman: Breast cancer and cardiovascular disease.
    Clin Cardiol 2018 Feb 15. Epub 2018 Feb 15.
    Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada.
    Cardiovascular disease remains the leading cause of death in women in the United States and is a major public health issue for all women, but it is of increasing concern to breast cancer survivors. Advancements in early detection and breast cancer therapy have resulted in over 90% of women surviving 5 years past their diagnosis of breast cancer. Nonetheless, with increased survivorship from breast cancer, there has been an increase in cardiovascular disease in these women. Read More

    Adverse pregnancy outcomes and future maternal cardiovascular disease.
    Clin Cardiol 2018 Feb 15. Epub 2018 Feb 15.
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Cardiovascular disease (CVD) remains the leading cause of death in women. Although traditional risk factors increase later-life CVD, pregnancy-associated complications additionally influence future CVD risk in women. Recent guidelines for the prevention of CVD in women have added adverse pregnancy outcomes as major CVD risk factors. Read More

    Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial.
    Clin Cardiol 2018 Jan 1;41(1):39-45. Epub 2018 Feb 1.
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.
    Background: Atrial fibrillation (AF) increases risk of stroke 5-fold. Carotid artery disease (CD) also augments the risk of stroke, yet there are limited data about the interplay of these 2 diseases and clinical outcomes in patients with comorbid AF and CD.

    Hypothesis: Among patients with both AF and CD, use of rivaroxaban when compared with warfarin is associated with a lower risk of stroke. Read More

    Subvalvular aortic stenosis: a review of current literature.
    Clin Cardiol 2018 Jan 29;41(1):131-136. Epub 2018 Jan 29.
    Division of Cardiology, University of Nevada School of Medicine, Las Vegas.
    Subvalvular aortic stenosis (SAS) is one of the common adult congenital heart diseases, with a prevalence of 6.5%. It is usually diagnosed in the first decade of life. Read More

    High-risk inferior myocardial infarction: Can speckle tracking predict proximal right coronary lesions?
    Clin Cardiol 2018 Jan 29;41(1):104-110. Epub 2018 Jan 29.
    Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: It is important to diagnose right ventricular (RV) infarction in the setting of acute inferior myocardial infarction (MI). We aimed to improve the diagnostic accuracy of RV infarction and identify a high-risk subset of inferior MI patients with proximal RCA lesions.

    Hypothesis: We tried to find the link between speckle tracking and coronaries in high risk inferior infarction METHODS: This study included 68 patients within 24 hours of first acute inferior MI. Read More

    Safety and efficacy of second-generation drug-eluting stents compared with bare-metal stents: An updated meta-analysis and regression of 9 randomized clinical trials.
    Clin Cardiol 2018 Jan 25;41(1):151-158. Epub 2018 Jan 25.
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville.
    The efficacy of second-generation drug-eluting stents (DES; eg, everolimus and zotarolimus) compared with bare-metal stents (BMS) in patients undergoing percutaneous coronary intervention was challenged recently by new evidence from large clinical trials. Thus, we aimed to conduct an updated systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the efficacy and safety of second-generation DES compared with BMS. Electronic databases were systematically searched for all RCTs comparing second-generation DES with BMS and reporting clinical outcomes. Read More

    Electrophysiological characteristics and catheter ablation of symptomatic focal premature atrial contractions originating from pulmonary veins and non-pulmonary veins.
    Clin Cardiol 2018 Jan 25;41(1):74-80. Epub 2018 Jan 25.
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
    Background: We aimed to explore electrophysiological characteristics of premature atrial contractions (PACs) originating from pulmonary veins (PVs) and non-PVs and to evaluate the effectiveness and safety of catheter ablation for PACs.

    Hypothesis: Symptomatic PACs originated from different positions and whether could be ablated.

    Methods: Symptomatic, frequent, and drug-refractory PAC patients were enrolled in this study. Read More

    Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study.
    Clin Cardiol 2018 Jan 24;41(1):13-19. Epub 2018 Jan 24.
    Department of Cardiology, California Cardiovascular Institute, Fresno, California.
    Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk. High-purity eicosapentaenoic acid (EPA) added to a statin has been shown to reduce CV events and induce regression of coronary atherosclerosis in imaging studies; however, data are from Japanese populations without high triglyceride (TG) levels and baseline EPA serum levels greater than those in North American populations. Icosapent ethyl is a high-purity prescription EPA ethyl ester approved at 4 g/d as an adjunct to diet to reduce TG levels in adults with TG levels >499 mg/dL. Read More

    Growth differentiation factor 15 is associated with left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation.
    Clin Cardiol 2018 Jan 24;41(1):34-38. Epub 2018 Jan 24.
    Department of Neurology, Zhejiang Hospital, Hangzhou, Zhejiang Province, China.
    Background: There is evidence suggesting that growth differentiation factor 15 (GDF-15) appears to be associated with stroke in patients with atrial fibrillation (AF). AF-related thromboembolic stroke is predominantly attributed to the thrombus from the left atrium (LA) or left atrial appendage (LAA).

    Hypothesis: GDF-15 is related to LA/LAA thrombus in nonvalvular AF (NVAF) patients. Read More

    Long-term impacts of hemodialysis on the right ventricle: Assessment via 3-dimensional speckle-tracking echocardiography.
    Clin Cardiol 2018 Jan 24;41(1):87-95. Epub 2018 Jan 24.
    Department of Echocardiography, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai Institute of Medical Imaging, Shanghai, China.
    Background: Right ventricular (RV) dysfunction is a major cause of death in patients undergoing maintenance hemodialysis (MHD). We used 3-dimensional speckle-tracking echocardiography (3DSTE) to evaluate long-term impacts of MHD on RV function.

    Hypothesis: In this study, RV dysfunction in MHD patients will be revealed and studied in depth by 3DSTE. Read More

    Nutraceuticals in the management of patients with statin-associated muscle symptoms, with a note on real-world experience.
    Clin Cardiol 2018 Jan 24;41(1):159-165. Epub 2018 Jan 24.
    School of Medicine, Faculty of Health & Medical Sciences, University of Western Australia, Perth.
    There is considerable evidence for the role of low-density lipoprotein cholesterol (LDL-C) in the development of atherosclerotic cardiovascular disease. Although statin therapy remains the most frequency prescribed medication to reduce LDL-C and lower risk of cardiovascular disease, a considerable number of patients develop muscle-related side affects. This review summarizes recent literature supporting the role of nutraceuticals as LDL-C-lowering therapy in statin-intolerant patients, with evidence from our own clinical practices. Read More

    Agreement between coding schemas used to identify bleeding-related hospitalizations in claims analyses of nonvalvular atrial fibrillation patients.
    Clin Cardiol 2018 Jan 23;41(1):119-125. Epub 2018 Jan 23.
    Real-World Evidence Strategy and Outcomes Data Generation, Bayer AG, Berlin, Germany.
    Background: Schemas to identify bleeding-related hospitalizations in claims data differ in billing codes used and coding positions allowed. We assessed agreement across bleeding-related hospitalization coding schemas for claims analyses of nonvalvular atrial fibrillation (NVAF) patients on oral anticoagulation (OAC).

    Hypothesis: We hypothesized that prior coding schemas used to identify bleeding-related hospitalizations in claim database studies would provide varying levels of agreement in incidence rates. Read More

    Long-term prognostic value of combined free triiodothyronine and late gadolinium enhancement in nonischemic dilated cardiomyopathy.
    Clin Cardiol 2018 Jan 23;41(1):96-103. Epub 2018 Jan 23.
    Departments of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: Thyroid dysfunction and myocardial fibrosis are both associated with cardiovascular events in patients with dilated cardiomyopathy (DCM).

    Hypothesis: The combination of thyroid hormone (TH) and myocardial fibrosis (detected by late gadolinium enhancement [LGE]) is an independent and incremental predictor of adverse events in DCM.

    Methods: We consecutively enrolled 220 idiopathic DCM patients with thyroid function and LGE assessment at Fuwai Hospital (China) from January 2010 to October 2011 and followed up through December 2015. Read More

    Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study.
    Clin Cardiol 2018 Jan 23;41(1):20-27. Epub 2018 Jan 23.
    Department of Cardiology, Castle Hill Hospital, Hull York Medical School (at University of Hull), Kingston upon Hull, HU16 5JQ, United Kingdom.
    Background: The pulmonary artery (PA) distends as pressure increases.

    Hypothesis: The ratio of PA to aortic (Ao) diameter may be an indicator of pulmonary hypertension and consequently carry prognostic information in patients with chronic heart failure (HF).

    Methods: Patients with chronic HF and control subjects undergoing cardiac magnetic resonance imaging were evaluated. Read More

    Use of two-dimensional speckle tracking echocardiography to predict cardiac events: Comparison of patients with acute myocardial infarction and chronic coronary artery disease.
    Clin Cardiol 2018 Jan 23;41(1):111-118. Epub 2018 Jan 23.
    Department of Cardiology, University Hospital Aachen, Rhenish-Westphalian Technical University, Aachen, Germany.
    Background: Two-dimensional speckle strain (2D STE) echocardiography can aid in the prognosis of acute myocardial infarction (AMI) and chronic coronary artery disease (CAD).

    Hypothesis: Differences occur in the prediction of cardiac events using 2D STE in AMI vs CAD patients.

    Methods: In this prospective study, 94 patients with a first AMI and successful revascularization, and 137 patients with stable CAD after complete revascularization were included. Read More

    The evolving view of coronary artery calcium and cardiovascular disease risk.
    Clin Cardiol 2018 Jan 22;41(1):144-150. Epub 2018 Jan 22.
    Division of Preventive Medicine, Department of Family and Public Health, University of California San Diego.
    Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. Read More

    Association between clinical factors and self-underestimation of cardiovascular risk in subjects submitted to a routine health evaluation.
    Clin Cardiol 2018 Jan 22;41(1):28-33. Epub 2018 Jan 22.
    Hospital Israelita Albert Einstein, São Paulo, Brazil.
    Background: The perception of cardiovascular (CV) risk is essential for adoption of healthy behaviors. However, subjects underestimate their own risk.

    Hypothesis: Clinical characteristics might be associated with self-underestimation of CV risk. Read More

    Predictors of arrhythmia recurrence in patients with heart failure undergoing left atrial ablation for atrial fibrillation.
    Clin Cardiol 2018 Jan 22;41(1):63-67. Epub 2018 Jan 22.
    Department of Cardiology, Electrophysiology Laboratory, Evangelismos General Hospital of Athens, Athens, Greece.
    Background: Atrial fibrillation (AF) ablation is increasingly used in patients with reduced left ventricular ejection fraction (LVEF). The aim of the present study was to evaluate the long-term results of a single radiofrequency catheter ablation procedure in heart failure (HF) patients with AF.

    Hypothesis: We tested the hypothesis that left atrial ablation is an effective therapeutic modality in patients with heart failure. Read More

    Early versus delayed invasive strategy for intermediate- and high-risk acute coronary syndromes managed without P2Yreceptor inhibitor pretreatment: Design and rationale of the EARLY randomized trial.
    Clin Cardiol 2018 Jan 22;41(1):5-12. Epub 2018 Jan 22.
    Aix-Marseille Université, AP-HM, Unité INSERM 1076, Unité de Soins Intensifs Cardiologiques, Department of Cardiology, Hôpital Nord, Marseille, France.
    According to recent literature, pretreatment with a P2YADP receptor antagonist before coronary angiography appears no longer suitable in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) due to an unfavorable risk-benefit ratio. Optimal delay of the invasive strategy in this specific context is unknown. We hypothesize that without P2YADP receptor antagonist pretreatment, a very early invasive strategy may be beneficial. Read More

    Reassessment of cardiovascular parameters and comorbidities in implantable cardioverter-defibrillator patients at the time of first replacement.
    Clin Cardiol 2018 Jan 22;41(1):57-62. Epub 2018 Jan 22.
    Department of Cardiology, University Hospital Basel, Basel, Switzerland.
    Background: Guidelines provide extensive recommendations regarding implantable cardioverter-defibrillator (ICD) implantation. However, ICD replacement at the time of battery depletion is rarely studied.

    Hypothesis: Our objectives were to identify patients at high-risk of death after ICD replacement, with a reassessment of changes in risk factors and comorbidities at the time of replacement, and to determine predictors for subsequent mortality. Read More

    Effect of body mass index on survival after sudden cardiac arrest.
    Clin Cardiol 2018 Jan 22;41(1):46-50. Epub 2018 Jan 22.
    Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
    Background: Although elevated body mass index (BMI) is a risk factor for cardiac disease, patients with elevated BMI have better survival in the context of severe illness, a phenomenon termed the "obesity paradox."

    Hypothesis: Higher BMI is associated with lower mortality in sudden cardiac arrest (SCA) survivors.

    Methods: Data were collected on 1433 post-SCA patients, discharged alive from the hospitals of the University of Pittsburgh Medical Center between 2002 and 2012. Read More

    Antithrombotic therapy in peripheral artery disease: A review of the EUCLID trial results and current ongoing trials.
    Clin Cardiol 2018 Jan 22;41(1):137-143. Epub 2018 Jan 22.
    School of Medicine, Duke University Medical Center, Durham, North Carolina.
    In addition to risk-factor modification, antithrombotic therapy is the hallmark of management to reduce cardiovascular ischemic events in patients with peripheral artery disease (PAD). Currently, the guidelines recommend long-term antiplatelet therapy with aspirin or clopidogrel in this patient population to reduce myocardial infarction, stroke, and vascular death. Past outcomes studies have shown some benefit of ticagrelor, another antiplatelet agent, as compared with clopidogrel in patients with coronary disease and concomitant PAD. Read More

    Variation in practice patterns and outcomes across United Network for Organ Sharing allocation regions.
    Clin Cardiol 2018 Jan 22;41(1):81-86. Epub 2018 Jan 22.
    Department of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut.
    Background: The number of heart transplants performed is limited by organ availability and is managed by the United Network for Organ Sharing (UNOS). Efforts are underway to make organ disbursement more equitable as demand increases.

    Hypothesis: Significant variation exists in contemporary patterns of care, wait times, and outcomes among patients undergoing heart transplantation across UNOS regions. Read More

    The effect of fasting status on lipids, lipoproteins, and inflammatory biomarkers assessed after hospitalization for an acute coronary syndrome: Insights from PROVE IT-TIMI 22.
    Clin Cardiol 2018 Jan 28;41(1):68-73. Epub 2017 Dec 28.
    Department of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts.
    Background: For decades, fasting for 8 to 12 hours has been recommended for measurement of lipid profiles. The effect of fasting on low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) has been described in healthy cohorts and those with stable disease states. Recently, guidelines suggested that fasting may not be necessary due to its small effect on lipid measures. Read More

    Association between ideal cardiovascular health metrics and risk of cardiovascular events or mortality: A meta-analysis of prospective studies.
    Clin Cardiol 2017 Dec 26;40(12):1339-1346. Epub 2017 Dec 26.
    Department of Disease Control and Prevention, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
    Background: Observational studies evaluating the relationship between ideal cardiovascular health (CVH) metrics and risk of cardiovascular (CV) events and mortality yielded inconsistent results.

    Hypothesis: Improvement in CVH metrics can result in substantial reductions in the risk of cardiovascular disease (CVD), stroke, and mortality.

    Methods: We examined associations between ideal CVH metrics and CV events and mortality by conducting a meta-analysis of data from prospective cohort studies identified by searching PubMed and Web of Science from their inception to February 2017 and reviewing the reference lists of the retrieved articles. Read More

    Acute kidney injury requiring dialysis and in-hospital mortality in patients with chronic kidney disease and non-ST-segment elevation acute coronary syndrome undergoing early vs delayed percutaneous coronary intervention: A nationwide analysis.
    Clin Cardiol 2017 Dec 20;40(12):1303-1308. Epub 2017 Dec 20.
    Divison of Cardiology, Lehigh Valley Hospital, Allentown, Pennsylvania.
    Background: Chronic kidney disease (CKD) is a well-known risk factor for coronary artery disease and is associated with poor outcomes following an acute coronary syndrome (NSTE-ACS). The optimal timing of an invasive strategy in patients with CKD and NSTE-ACS is unclear.

    Hypothesis: Timing of PCI in CKD patients will not affect the risk of mortality or incidence of dialysis. Read More

    Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore.
    Clin Cardiol 2017 Dec 18;40(12):1218-1226. Epub 2017 Dec 18.
    Department of Pharmacy, Khoo Teck Puat Hospital, Singapore.
    Background: Real-world effectiveness and safety of antithrombotics in nonvalvular atrial fibrillation (NVAF) patients in Singapore has not been thoroughly studied.

    Hypothesis: Users of various antithrombotics experience a significantly different risk of stroke and major bleed compared with warfarin users.

    Methods: This multicenter retrospective cohort study included patients age ≥ 21 years newly diagnosed with NVAF between July 2012 and September 2015. Read More

    Laboratory characteristics of ischemic stroke patients with atrial fibrillation on or off therapeutic warfarin.
    Clin Cardiol 2017 Dec 18;40(12):1347-1351. Epub 2017 Dec 18.
    Department of Neurology, University of Texas Lozano Long School of Medicine, San Antonio.
    Background: In patients with atrial fibrillation (AF), despite adequate anticoagulation, ischemic stroke (IS) is an uncommon yet concerning occurrence.

    Hypothesis: Specific laboratory parameters may affect the efficacy of warfarin despite therapeutic international normalized ratio (INR) in patient with AF who present with IS.

    Methods: We used the database from a multicenter clinical trial to identify AF patients who presented with IS. Read More

    Acute kidney injury post-transcatheter aortic valve replacement.
    Clin Cardiol 2017 Dec 18;40(12):1357-1362. Epub 2017 Dec 18.
    Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
    Transcatheter aortic valve replacement (TAVR) is a treatment option in high-risk patients with severe aortic stenosis who are not surgical candidates. In light of emerging evidence, it is being increasingly performed even in intermediate-risk patients in recent years. Patients who develop acute kidney injury (AKI) following TAVR are known to have worse outcomes. Read More

    Gender differences in the association between discharge hemoglobin and 12-month mortality after acute myocardial infarction.
    Clin Cardiol 2017 Dec 16;40(12):1279-1284. Epub 2017 Dec 16.
    Division of Cardiology, Aurora, Colorado.
    Background: Anemia at discharge in patients with acute myocardial infarction is associated with poor prognosis; whether this differs in women and men or if there is a threshold value at which these relationships change is unknown.

    Hypothesis: Women have a lower discharge hemoglobin (Hb) at which outcomes worsen.

    Methods: We identified patients with acute myocardial infarction in the TRIUMPH registry between 2005 and 2008. Read More

    Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With Acute Heart Failure (ACTIVE-EMS): Rationale and protocol for a multicenter randomized controlled trial.
    Clin Cardiol 2017 Dec 16;40(12):1189-1196. Epub 2017 Dec 16.
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.
    In elderly patients with acute heart failure (AHF), clinical outcome is adversely affected by frailty. Although a number of potentially effective interventions for frailty have been reported, little is known about the effects of rehabilitation programs in frail elderly AHF patients. We postulated that addition of electrical muscle stimulation (EMS), which induces muscle contraction without requiring patient volition, to early rehabilitation would be efficacious in frail elderly AHF patients. Read More

    Appropriateness vs value: Echocardiography in primary care.
    Clin Cardiol 2017 Dec 16;40(12):1212-1217. Epub 2017 Dec 16.
    Department of Medicine, Western Connecticut Health Network, Danbury, Connecticut.
    Background: Despite efforts targeting the growth of healthcare spending within the United States, the current increase in expenditures remains a widespread systemic issue. The overuse of healthcare testing has previously been identified as a modifiable contributing factor. One such test, echocardiography, has seen a continuous increase in its rate of use. Read More

    Prevalence and predictors of elevated high-sensitivity C-reactive protein in post-myocardial infarction patients: Insights from the VIRGO and TRIUMPH registries.
    Clin Cardiol 2017 Dec 16;40(12):1205-1211. Epub 2017 Dec 16.
    Department of Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, Missouri.
    Elevated high-sensitivity C-reactive protein (hs-CRP) is associated with worse cardiovascular outcomes in patients with acute myocardial infarction (AMI), but little is known about the distribution of hs-CRP levels and predictors of elevated hs-CRP after AMI in the real world. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) and Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) are prospective AMI registries in the United States that assessed hs-CRP levels 30 days after AMI. TRIUMPH additionally assessed hs-CRP levels at the time of AMI and at 6 months. Read More

    High-volume forced diuresis with matched hydration using the RenalGuard System to prevent contrast-induced nephropathy: A meta-analysis of randomized trials.
    Clin Cardiol 2017 Dec 16;40(12):1242-1246. Epub 2017 Dec 16.
    Department of Medicine, Division of Cardiology, University of Tennessee, Memphis.
    Background: Contrast-induced nephropathy (CIN) is a well-recognized complication of coronary angiography that is associated with poor outcomes. Several small randomized controlled trials (RCTs) have recently shown that in patients with chronic kidney disease (CKD), furosemide-induced forced diuresis with matched hydration using the RenalGuard system can prevent its occurrence. However, individual studies have been underpowered and thus cannot show significant differences in major clinical endpoints. Read More

    QTc dispersion and Cornell duration product can predict 10-year outcomes in hypertensive patients with left ventricular hypertrophy.
    Clin Cardiol 2017 Dec 16;40(12):1236-1241. Epub 2017 Dec 16.
    Department of Cardiology, Clinic for Internal Diseases Intermedica, Niš, Serbia; and Veterans Affairs Medical Center, Washington, District of Columbia.
    Background: Persistent and adequate treatment of patients with arterial hypertension leads to more favorable disease outcome.

    Hypothesis: Aside for the present left ventricular hypertrophy (LVH), there are other non-invasive parameters which can represent additional predictors of unfavorable prognosis in patients with essential arterial hypertension during the 10-year follow-up.

    Methods: A hypertensive group with LVH (124 patients; age 57. Read More

    Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study.
    Clin Cardiol 2017 Dec 16;40(12):1197-1204. Epub 2017 Dec 16.
    Concord Hospital and University of Sydney, Sydney, Australia.
    The long-term progression of coronary artery disease as defined by the natural disease course years after a myocardial infarction (MI) is an important but poorly studied area of clinical research. The long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study was designed to address this knowledge gap by evaluating patient management and clinical outcomes following MI in different regions worldwide. TIGRIS (ClinicalTrials. Read More

    Impact of obstructive sleep apnea on cardiovascular outcomes in patients with acute symptomatic pulmonary embolism: Rationale and methodology for the POPE study.
    Clin Cardiol 2017 Dec 16;40(12):1182-1188. Epub 2017 Dec 16.
    Respiratory Department, Hospital Ramón y Cajal, and Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain.
    In normotensive patients with acute symptomatic pulmonary embolism (PE), the effect of undiagnosed obstructive sleep apnea (OSA) on cardiovascular (CV) outcomes lacks clarity. The Prognostic Significance of Obstructive Sleep Apnea in Patients With Acute Symptomatic Pulmonary Embolism (POPE) study is a multicenter, observational study designed to prospectively assess the prognostic significance of concomitant OSA in hemodynamically stable outpatients with acute symptomatic PE. Adult patients with acute stable PE are eligible. Read More

    Lithium-induced electrocardiographic changes: A complete review.
    Clin Cardiol 2017 Dec 16;40(12):1363-1367. Epub 2017 Dec 16.
    Department of Cardiology, Rochester Regional Health, Rochester, New York.
    Lithium has been used for the treatment of bipolar disorder for more than 6 decades. Reports of cardiac side effects resulting in both benign electrocardiographic (ECG) changes and near fatal arrhythmias have been reported in the literature. A systematic literature search was conducted on 2 electronic databases-PubMed and Medline-for the time period between January 1970 and March 2016 using the key word "lithium," along with "electrocardiography" or "ECG. Read More

    Real-world incidence of efficacy and safety outcomes in patients on direct oral anticoagulants with left ventricular systolic dysfunction at a tertiary referral center.
    Clin Cardiol 2017 Dec 16;40(12):1328-1332. Epub 2017 Dec 16.
    Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona.
    Background: Patients with heart failure (HF) have increased risk for thromboembolic events. Real-world incidences of efficacy and safety outcomes of direct oral anticoagulants (DOACs) in patients with left ventricular systolic dysfunction (LVSD) are of growing clinical interest.

    Hypothesis: Real-world efficacy and safety outcomes of DOACs in patients with LVSD will be similar to those of LVSD or HF subgroups in the RE-LY, ROCKET-AF, and ARISTOTLE trials. Read More

    Cardiovascular safety of NSAIDs: Additional insights after PRECISION and point of view.
    Clin Cardiol 2017 Dec 16;40(12):1352-1356. Epub 2017 Dec 16.
    Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, Virginia.
    Increasing numbers of patients with arthritis use nonsteroidal anti-inflammatory drugs (NSAIDs), some for long periods. The relative cardiovascular safety of NSAID use is of considerable concern, particularly among patients with or at risk of cardiovascular disease. Until recently, the evidence base was limited to older trials with small sample sizes. Read More

    Left atrial function and mortality in the oldest old.
    Clin Cardiol 2017 Dec 16;40(12):1323-1327. Epub 2017 Dec 16.
    Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Background: Previous studies demonstrated that left atrium (LA) size is associated with mortality in an elderly population. It remains unclear whether indices of LA function including reservoir, conduit, or booster elements of LA function provide incremental prognostic information.

    Hypothesis: Echocardiographic measures of the various parameters of LA function would predict 5-year mortality in a community-dwelling population of 85 to 86 year olds independently of LA volume. Read More

    Impact of coronary artery disease in patients undergoing transcatheter aortic valve replacement: Insights from the FRANCE-2 registry.
    Clin Cardiol 2017 Dec 16;40(12):1316-1322. Epub 2017 Dec 16.
    Department of Cardiology, European Hospital of Georges Pompidou, Public Assistance Hospitals of Paris, Paris Descartes University, Paris, France.
    Background: Coronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve replacement (TAVR). However, the impact of CAD distribution before TAVR on short- and long-term prognosis remains unclear.

    Hypothesis: We hypothesized that the long-term clinical impact differs according to CAD distribution in patients undergoing TAVR using the FRench Aortic National CoreValve and Edwards (FRANCE-2) registry. Read More

    Clinical efficacy of irrigated catheter application of amiodarone during ablation of persistent atrial fibrillation.
    Clin Cardiol 2017 Dec 16;40(12):1333-1338. Epub 2017 Dec 16.
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
    Background: Pharmacological treatment during ablation of persistent atrial fibrillation (AF) is common, but utility of irrigated catheter application of amiodarone during ablation of persistent AF remains unclear.

    Hypothesis: Irrigated catheter application of amiodarone improves quality of ablation and long-term outcomes.

    Methods: We enrolled 90 persistent AF patients who underwent catheter ablation. Read More

    Isometric handgrip echocardiography: A noninvasive stress test to assess left ventricular diastolic function.
    Clin Cardiol 2017 Dec 16;40(12):1247-1255. Epub 2017 Dec 16.
    Department of Kinesiology, University of Texas at Arlington.
    Background: Cycle exercise echocardiography is a useful tool to "unmask" diastolic dysfunction; however, this approach can be limited by respiratory and movement artifacts. Isometric handgrip avoids these issues while reproducibly increasing afterload and myocardial oxygen demand.

    Hypothesis: Isometric handgrip echocardiography (IHE) can differentiate normal from abnormal diastolic function. Read More

    Culprit plaque characteristics in women vs men with a first ST-segment elevation myocardial infarction: In vivo optical coherence tomography insights.
    Clin Cardiol 2017 Dec 16;40(12):1285-1290. Epub 2017 Dec 16.
    Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
    Background: It is unclear whether more severe coronary atherosclerosis is a prerequisite to an initial acute coronary event in women vs men.

    Hypothesis: Women may have more severe coronary atherosclerosis than men in patients with acute coronary event.

    Methods: We used intravascular optical coherence tomography (OCT) to evaluate gender differences in culprit-plaque morphology in patients with a first ST-segment elevation myocardial infarction (STEMI). Read More

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