4,311,940 results match your criteria Clinical cancer research : an official journal of the American Association for Cancer Research[Journal]


A clinical multi-center registry study on digital nerve repair using a biodegradable nerve conduit of PGA with external and internal collagen scaffolding.

Microsurgery 2018 Dec 18. Epub 2018 Dec 18.

Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Kindai University, Osakasayama, Japan.

Background: In this study, we evaluated the clinical efficacy of a biodegradable nerve conduit constructed of polyglycolic acid (PGA) tube with external and internal collagen scaffolding for digital nerve repair.

Patients And Methods: A multi-center registry study was conducted in 11 locations between July 2013 and May 2016. Multiple mechanisms of injury included clean-cut (12 patients), crush (5 patients), and avulsion (3 patients) types of injuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/micr.30417DOI Listing
December 2018

Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists.

J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14604DOI Listing
December 2018

Optimal surgical treatment in patients with T1b gallbladder cancer: An international multicenter study.

J Hepatobiliary Pancreat Sci 2018 Dec;25(12):533-543

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to the lack of evidence and the difficulty of anatomy and pathological standardization.

Methods: A total of 272 patients with T1b GBC who underwent surgical resection at 14 centers with specialized hepatobiliary-pancreatic surgeons and pathologists in Korea, Japan, Chile, and the United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according to the types of surgery were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jhbp.593DOI Listing
December 2018

Differentiation of functional gastrointestinal disorders from healthy volunteers by lactulose hydrogen breath test and test meal.

J Gastroenterol Hepatol 2018 Nov 22. Epub 2018 Nov 22.

Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.

Background And Aim: Functional dyspepsia (FD) is a common disorder of gut-brain interaction with incompletely understood pathophysiology. Consequently, heterogeneous expert opinions on diagnostic tests and assessment of treatment efficacies exist. So far, no consensus about the most relevant diagnostic and outcome tool has been reached. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14551DOI Listing
November 2018

Intra-articular Corticosteroids for Knee Pain-What Have We Learned from the Equine Athlete and Current Best Practice.

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopaedic Surgery, Division of Sports Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

The use of intra-articular corticosteroids for traumatic arthritis and osteoarthritis (OA) is common in the horse. The beneficial and deleterious effects of the principal corticosteroids used betamethasone esters (Celestone [Soluspan], methylprednisolone acetate [Depo Medrol], and triamcinolone acetonide [TA] [Vetalog or Kenalog]) have been defined for the horse. While TA has both disease-modifying as well as symptom-modifying effects, methyl prednisolone acetate has deleterious effects on the articular cartilage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676449DOI Listing
December 2018

Is There a Difference between Cemented and Uncemented Femoral Stem Extensions in Revision Knee Arthroplasty?

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Chapel Hill Orthopedics Surgery and Sports Medicine, Chapel Hill, North Carolina.

A stem is usually recommended for the femoral component in revision total knee arthroplasty (TKA) for reasons of alignment, fixation, and bone loss. However, the optimal method of fixation for the femoral component stem remains controversial. We queried the prospective revision TKA database of one surgeon and performed a clinical and radiographic evaluation of 84 knee revisions in which a femoral component stem extension was implanted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676567DOI Listing
December 2018

Depression and Diabetic Peripheral Neuropathy: Birds of a Feather, But When do They Flock Together?

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

The association between diabetes and depression is well recognised. Similarly, diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes. Given the high prevalence of these conditions individually, it is hardly surprising they frequently interact, conferring additional morbidity and a higher mortality risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0808-4269DOI Listing
December 2018

An Update on Addison's Disease.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced.PAI is a rare disease but recent data report an increasing prevalence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0804-2715DOI Listing
December 2018

[50 Years ago: First Successful Treatment of Acute Allograft Rejection after a Human Heart Transplantation].

Authors:
Walter G Land

Dtsch Med Wochenschr 2018 Dec 18;143(25):1864-1865. Epub 2018 Dec 18.

The first clinical use of the "Munich antilymphocyte globulin" (ALG) at the occasion of the first successful human heart transplantation is briefly described. The cardiac transplantation was carried out by Christiaan Barnard and his team in Cape Town, South Africa, in 1968. The patient developed an acute allograft rejection which could be successfully reversed within three weeks using the intravenous administration of ALG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0573-5623DOI Listing
December 2018

[Double Running Suture Line Repair in Primary Umbilical Hernias - Analysis after 282 Cases].

Zentralbl Chir 2018 Dec 18. Epub 2018 Dec 18.

Klinik für Allgemein-, Viszeral- und Schilddrüsenchirurgie, BETHLEHEM Gesundheitszentrum Stolberg gGmbH, Deutschland.

Introduction: There is an ongoing debate as to which patients presenting with an umbilical hernia should be operated with the sole suture technique or augmented by mesh. After treating most of our patients for a long period uniformly with a double running suture line, the aim of this study was to evaluate the performance of this strategy - especially in patients with larger defects.

Patients And Methods: From 1/2004 to 4/2017, all patients operated on for an umbilical hernia were identified through our hospital information system (KIS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0788-9533DOI Listing
December 2018

[A case of gout secondary to primary myelofibrosis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1117-1119

Department of Rheumatology and Immunology,Peking University First Hospital, Beijing 100034, China.

A 52-year-old man was referred to our department with a 2-year history of polyarthritis. He was diagnosed as gout due to acute arthritis of bilateral feet dorsum 2 years ago,but he didn't receive any standard treatment. 1 year ago,there were more and more joints evolved during the gout attack, and many subcutaneous nodules occurred. Read More

View Article

Download full-text PDF

Source
December 2018

[Systemic lupus erythematosus with acquired hemophilia A: a case report].

Authors:
F Yang Y S Zhou Y Jia

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1108-1111

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Acquired hemophilia A (AHA) is anunusual disease resulting from autoantibodies (inhibitors) against coagulation factor VIII (FVIII) and clinically manifests as bleeding, which sometimes can cause potentially limb-threatening or life-threatening situations. AHA is associated with cancers, auto-immune disorders, infections, dermatologic conditions and certain medications, among which it is commonly secondary to multiple rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), pollymyositis, autoimmune hemolytic anemia and undifferentiated connective tissue disease. In autoimmune diseases, it may be the result of autoantibody producing against FVIII, and some cases of AHA may act as the first manifestation of SLE. Read More

View Article

Download full-text PDF

Source
December 2018

[Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1102-1107

Department of Rheumatology and Immunology, Peking University First Hospital, Beijing 100034, China.

This case report concerns a 22-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE). She had intermittent fever, butterfly erythema, photosensitivity, oral ulcers, and multiple arthralgia in the past seven years, but she did not adhere to regular treatments. The edema of the lower extremities and face aggravated in the recent two weeks, so she was admitted to our Department of Rheumatology and Clinical Immunology. Read More

View Article

Download full-text PDF

Source
December 2018

[Clinicopathological analysis of aggressive angiomyxoma of soft tissue in abdomino-pelvic cavity].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1098-1101

Department of Pathology, Peking University International Hospital, Beijing 102206, China.

Aggressive angiomyxoma is a rare mesenchymal tumor. To discuss the clinicopathological characteristics, treatment and prognosis of aggressive angiomyxoma, four cases of aggressive angiomyxoma of soft tissue in abdominopelvic cavity were collected from January 2015 to August 2017 in Peking University International Hospital. The clinical data, imaging examination, histopathological features, immunophenotype, therapy and prognosis were analysed. Read More

View Article

Download full-text PDF

Source
December 2018

[Efficacy and safety of applying ultrasonic osteotome in cervical expansive open-door laminoplasty].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1092-1097

Research Center of Clinical Epidemicology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the safety and efficacy of applying ultrasonic osteotome in patients undergoning cervical expansive open-door laminoplasty (CEOL).

Methods: In the study, 94 consecutive patients who were administrated in the spine group of Orthopedic Department of Peking University Third Hospital from March 2015 to March 2016 were reviewed retrospectively. All the patients were diagnosed as multilevel cervical spondylosis myelopathy and underwent CEOL. Read More

View Article

Download full-text PDF

Source
December 2018

[Retrospective analysis of early dental implant failure].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1088-1091

First Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China.

Objective: To analyze the risk factors of early dental implant failure,treatment and prognosis.

Methods: Cases of dental implants in the first clinical division from January 2000 to December 2016 were selected according to inclusion criteria. The differences of gender,age,smoking,location of implants, healing abutments and bone graft were compared between early failed implants and success implants. Read More

View Article

Download full-text PDF

Source
December 2018

[Staining effect of bovine incisors in vitro by tea solutions].

Authors:
M M Zhu Y L Li J Pan

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1083-1087

Department of General, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To determine the optimum staining condition of tea solutions on bovine incisors in vitro, by comparing the color stability of tooth surface of different concentrations of tea solutions and methods on bovine incisors in vitro.

Methods: Twenty bovine incisors with color surface A1 were chosen, then randomly divided into 4 groups (n=10). Group 1: soaked with 2% tea solution continuously for 6 days; group 2: soaked with 2% tea solution for 6 days, but changed fresh tea solution everyday; group 3: soaked with 1% tea solution continuously for 6 days; group 4: soaked with 1% tea solution for 6 days but fresh tea solution changed every day. Read More

View Article

Download full-text PDF

Source
December 2018

[Effects of intranasal dexmedetomidine for children undergoing dental rehabilitation under general anesthesia: a double-blinded randomized controlled trial].

Authors:
L Gao Y Liu X D Yang

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1078-1082

Department of Anesthesiology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To observe the preoperative sedation, the status of separation from parents, compliance with the mask, hemodynamic parameters and postoperative agitation of intranasal dexmedetomidine (DEX) premedication on children undergoing dental rehabilitation under general anesthesia.

Methods: In the study, 60 children of American Society of Anesthesiology classification (ASA I-II), aged 2-9 years, were randomly assigned to one of two equal groups. Thirty minutes before operation, control group received intranasal placebo (0. Read More

View Article

Download full-text PDF

Source
December 2018

[Clinical analysis of candidemia in immunocompetent patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1063-1069

Department of Nosocomial Infection,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the etiological and clinical characteristics of immunocompetent patients with candidemia.

Methods: The clinical and microbiological data of patients diagnosed as candidemia admitted in Peking University Third Hospital from January 2010 to June 2016 were retrospectively analyzed. Underlying diseases, Candida spp. Read More

View Article

Download full-text PDF

Source
December 2018

[Analysis of risk factors for acute lung injury/acute respiratory distress syndrome after esophagectomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1057-1062

Department of Critical Care Medicine, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.

Objective: To explore the incidence and risk factors for the acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) after resection of esophageal carcinoma.

Methods: We retrospectively analyzed 422 consecutive patients admitted to the Department of Critical Care Medicine with esophageal carcinoma undergoing esophagectomy from January 2010 to December 2016 in Peking University Cancer Hospital. ALI/ARDS were diagnosed, the patients were divided into ALI/ARDS group and control group without ALI/ARDS, the differences of clinical features were contrasted between the two groups, and the multivariate Logistic regression modeling was used to identify the independent risk factors for ALI/ARDS. Read More

View Article

Download full-text PDF

Source
December 2018

[Application of artificial ligament in treatment of lower abdominal wall reconstruction after pubic tumor resection].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1049-1052

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China.

Objective: For patients who had hemipelvectomies involving the resection of a portion or the whole of the pubis, bony reconstruction was not recommended commonly. However, the soft tissue reconstruction of the lower abdominal wall may benefit these patients. The object of the study was to determine the clinical effect of lower abdominal wall reconstruction with LARS ligament after pubic tumor resection interms of patient-reported and objective outcome. Read More

View Article

Download full-text PDF

Source
December 2018

[A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1044-1048

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To investigate the clinical characteristics, the medicine application and to evaluate the disease activity in patients with osteoarthritis (OA) in China.

Methods: This was a cross-sectional study. Totally 1 066 cases of OA from 40 hospitals in China from April to October 2017 were retrospectively enrolled. Read More

View Article

Download full-text PDF

Source
December 2018

[A cross-sectional study of the clinical features and physician visit patterns at onset of immunoglobulin G4 related disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1039-1043

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To comprehend clinical features and patient's physician visit patterns at onset of immunoglobulin G4 related disease (IgG4RD).

Methods: In the study, 100 patients with IgG4RD who received treatments in the Department of Rheumatology and Immunology of Peking University People's Hospital from Apr. 1st, 2017 to Apr. Read More

View Article

Download full-text PDF

Source
December 2018

[Case series and clinical analysis of 14 cases of catastrophic antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1033-1038

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Objective: Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a special subtype of antiphospholipid syndrome (APS) characterized by multiple intravascular thrombosis involving multiple organs systems or tissues simultaneously or continuously, high titer antiphospholipid antibodies and high mortality rate. This article's aims was to analyze the clinical manifestation, laboratory examination and treatment therapy of CAPS for the purpose of improving the understanding, diagnosis and treatment of the disease in clinical practice.

Methods: Retrospective analysis and descriptive statistics were applied to the clinical manifestations and laboratory findings of 14 CAPS cases from APS Shanghai Database (APS-SH) with catastrophic antiphospholipid. Read More

View Article

Download full-text PDF

Source
December 2018

[Increased serum soluble-endoglin level and its clinical significance in antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1027-1032

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To detect the serum levels of soluble endothelial glycoprotein endoglin (s-Eng) in patients with antiphospholipid syndrome (APS) and to evaluate the correlation between s-Eng levels and clinical features and laboratory parameters.

Methods: The levels of serum s-Eng were measured by enzyme linked immunosorbent assay (ELISA) in 139 patients with APS, 44 patients with SLE but no APS, 37 patients with primary Sjögren's syndrome (pSS), 23 patients with Bechet's disease (BD), 22 patients with systemic sclerosis (SSc) and 22 persistent anticardiolipin antibody (aCL) positive individuals without SLE or APS (simply aCL positive group) and 87 health controls (HC) without any auto-immune diseases. These APS patients included 64 primary APS patients and 75 APS patients secondary to SLE. Read More

View Article

Download full-text PDF

Source
December 2018

[Efficacy of mesenchymal stem cells on systemic lupus erythematosus:a meta-analysis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1014-1021

Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement and several typical autoantibodies. Mesenchymal stem cells (MSC) are multipotent stem cells with low immunogenicity that can differentiate into various kinds of cells, such as bone, cartilage, fat and skin tissue. MSC have immunomodulatory and reparative properties through interactions with immune cells. Read More

View Article

Download full-text PDF

Source
December 2018

[Multidisciplinary classification of magnetic resonance imaging features of neuropsychiatric lupus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1009-1013

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the clinical correlation between the manifestations of neuropsychiatric lupus (NPSLE) and brain magnetic resonance imaging (MRI).

Methods: Retrospective analysis of 65 neuropsychiatric lupus patients with brain MRI and clinical data from Peking University Third Hospital from January 2006 to October 2016, which was classified by rheumatologist, neurologists, and radiologists based on their brain MRI findings. The correlation between brain MRI findings and clinical manifestations was analyzed. Read More

View Article

Download full-text PDF

Source
December 2018

[Clinical and immunological characteristics of patients with systemic lupus erythematosus in Tibet plateau, China].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1004-1008

Department of Rheumatology and Immunology, Tibet Autonomous Region People's Hospital, Lhasa 850000, China.

Objective: To describe the clinical, immunological characteristics and organ involvement of patients with systemic lupus erythematosus (SLE) in Tibet plateau, China.

Methods: We retrospectively investigated 70 patients admitted in the Tibet Autonomous Region People's Hospital between May 2014 and April 2016. In the study, 120 hospitalized patients with SLE from the Department of Rheumatology and Immunology of the Peking University People's Hospital were randomly selected as the control (plain) group. Read More

View Article

Download full-text PDF

Source
December 2018

[Effect of functional exercises on patients with rheumatoid arthritis: a meta-analysis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):991-997

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To evaluate the effect of functional exercises on disease activity, joint function and quality of life of patients with rheumatoid arthritis (RA).

Methods: Randomized controlled trials were searched in Cochrane Library, PubMed, China National Knowledge Infrastructure (CNKI), VIP database and Wanfang database with keywords being "rheumatoid arthritis/RA", "function exercise (training)/joint exercise (training)/physical exercise (training)/resistance movement (exercise)/isotonic and isometric/stretching exercise/muscle exercise", and "trials/clinical trials". Then literature selection, extraction and literature quality evaluation were carried out by two of the authors independently following the including and excluding standards. Read More

View Article

Download full-text PDF

Source
December 2018

[Clinical characteristic of 74 cases of malignant tumor in rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):986-990

Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Objective: To investigate the clinical characteristics of rheumatoid arthritis (RA) patients with malignant tumor.

Methods: Retrospective summary was made of 1 562 in patients of RA from January 2011 to June 2017. In the study, 74 RA patients with malignant tumor were reviewed and analyzed, and the general conditions, tumor types, RA and tumor onset sequence, and the medication situation were analyzed. Read More

View Article

Download full-text PDF

Source
December 2018

[Value of serum matrix metalloproteinase 3 in the assessment of early rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):981-985

Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing 100044, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.

Objective: To investigate the expression level of serum matrix metalloproteinase 3 (MMP3) in early rheumatoid arthritis (ERA) patients with normal C-reaction protein (CRP) or erythrocyte sedimentation rate (ESR), and the significance in disease assessment.

Methods: In the study, 133 cases of early RA patients, 25 osteoarthritis (OA) patients and 60 healthy controls in Peking University People's Hospital from 2011 to 2015 were included. The RA patients were further divided into 4 groups according to levels of CRP and ESR: 88 patients with increased CRP and increased ESR, 15 patients with normal CRP and normal ESR, 17 patients with normal CRP but increased ESR, and 13 patients with increased CRP but normal ESR. Read More

View Article

Download full-text PDF

Source
December 2018

[Clinical significance of detection of soluble interleukin 2 receptor alpha chain in the assessment of rheumatoid arthritis disease activity].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):975-980

Department of Rheumatology and Immunology, Peking University People's Hospital,Beijing 100044, China.

Objective: To evaluate soluble interleukin-2 receptor alpha chain (sIL-2Rα, sCD25) in serum for the determination of rheumatoid arthritis (RA) activity.

Methods: Peripheral blood was collected from 108 patients with RA, 39 patients with osteoarthritis (OA) and 50 healthy control subjects, and synovial fluids were from 40 patients with RA. The sera from the patients with RA, the disease control group (osteoarthritis), the healthy control group, and the synovial fluids of the RA patients were detected by enzyme-linked immunosorbent assay (ELISA). Read More

View Article

Download full-text PDF

Source
December 2018

[Increased receptor activator of nuclear factor kappa B ligand expressed on B10 cells in rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):968-974

Department of Rheumatology and Immunology,the People's Hospital of China Three Gorges University,Yichang 443000, Hubei, China.

Objective: To detect receptor activator of nuclear factor kappa B ligand (RANKL) expressed on B10 cells in rheumatoid arthritis (RA) and to evaluate the correlation between RANKL-producing B10 cells in RA and clinical features and laboratory parameters, trying to reveal the possible role of B10 cells in the pathogenesis of RA and the potential mechanism of impaired immunosuppressive capacities.

Methods: 25 RA patients and 20 healthy volunteers were enrolled. These RA patients did not received treatment with glucocorticoids, disease-modifying anti-rheumatic drug and biologics during the recent half of a year. Read More

View Article

Download full-text PDF

Source
December 2018

[Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):956-961

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy. The immune factor accounts for a large proportion of many causes. Antiphospholipid antibody syndrome is the most common type of acquired thrombophilia disease. Read More

View Article

Download full-text PDF

Source
December 2018

Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice.

Med Sci Monit 2018 Dec 18;24:9213-9222. Epub 2018 Dec 18.

Department of Rheumatology, Qilu Hospital of Shandong University, Ji'nan, Shandong, China (mainland).

BACKGROUND Rheumatoid arthritis is an autoimmune disease that causes chronic joint inflammation and there is no cure. Baicalin, as an ingredient in the roots of Scutellaria baicalensis, is supposed to possess an anti-inflammatory effect. However, the protective effect of baicalin on collagen-induced arthritis requires further investigation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.910347DOI Listing
December 2018

Garcinia Multiflora Inhibits FPR1-Mediated Neutrophil Activation and Protects Against Acute Lung Injury.

Cell Physiol Biochem 2018 Dec 12;51(6):2776-2793. Epub 2018 Dec 12.

Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan,

Background/aims: Formyl peptide receptors (FPRs) recognize different endogenous and exogenous molecular stimuli and mediate neutrophil activation. Dysregulation of excessive neutrophil activation and the resulting immune responses can induce acute lung injury (ALI) in the host. Accordingly, one promising approach to the treatment of neutrophil-dominated inflammatory diseases involves therapeutic FPR1 inhibition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495970DOI Listing
December 2018

High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival.

Cell Physiol Biochem 2018 Dec 18;51(6):2829-2842. Epub 2018 Dec 18.

Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai,

Background/aims: Cullin 4A (CUL4A) is vital in cell survival, development, growth and cell cycle, it plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of CUL4A expression in colorectal cancer is unknown; in particular, the prognostic value of CUL4A combined with TP53 expression has not been explored.

Methods: We analyzed the expression of CUL4A in both public database (Oncomine) and 180 cases of colorectal cancer and paired normal tissues by real-time polymerase chain reaction and western blotting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496013DOI Listing
December 2018

Decreased Spontaneous Brain Activity and Functional Connectivity in Type 1 Diabetic Patients Without Microvascular Complications.

Cell Physiol Biochem 2018 Dec 12;51(6):2694-2703. Epub 2018 Dec 12.

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Background/aims: Type 1 diabetes mellitus (T1DM) has been proven to be associated with an increased risk of cognitive dysfunction. In this study, we aimed to investigate whether disrupted spontaneous activity and functional connectivity (FC) exist in T1DM patients using resting-state functional magnetic resonance imaging (rs-fMRI) and to detect the relationships of these parameters with cognitive impairment.

Methods: T1DM patients (n=35) were compared with age-, sex-, and education level-matched healthy controls (n=50) through rs-fMRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495960DOI Listing
December 2018

FOXD1 Promotes Cell Growth and Metastasis by Activation of Vimentin in NSCLC.

Cell Physiol Biochem 2018 Dec 12;51(6):2716-2731. Epub 2018 Dec 12.

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background/aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic development and organogenesis and functions as an oncogene in several cancers. However, the clinical significance and biological roles of FOXD1 in non-small cell lung cancer (NSCLC) remain largely unknown.

Methods: A total of 264 primary NSCLC tissue samples were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495962DOI Listing
December 2018

Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway.

Cell Physiol Biochem 2018 Dec 11;51(6):2604-2615. Epub 2018 Dec 11.

Department of Neurobiology, Tongji Medical School, Huazhong University of Science and Technology, Wuhan,

Background/aims: The Wnt signaling pathway has essential functions in the central nervous system, where it regulates the major physiological functions of neurons, including development, differentiation, and plasticity. Wnt signaling controls these cellular events; however, how Wnt pathways integrate into a coherent developmental program remains unclear.

Methods: The expression and secretion of different WNT ligands (Wnt-1, Wnt-3a, Wnt-4, Wnt-5a, Wnt-11), and the levels and activities of cyclin-dependent kinases (CDK2, CDK4, CDK6/cyclin D, cyclin E) or CDK5 (CDK5/p35 and p25) were measured in Rat cortex at different embryonic stages, and in RA/BDNF-induced differentiated SH-SY5Y cell model, by Quantitative real-time PCR (qPCR), western blotting, ELISA, and in vitro CDK5 kinase assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495932DOI Listing
December 2018

Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells.

Cell Physiol Biochem 2018 Dec 11;51(6):2616-2630. Epub 2018 Dec 11.

Institute of Nursing and Department of Nursing, Chang Gung Institute of Technology Chiayi Campus, Chiayi, Taiwan.

Background/aims: Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation and apoptosis and have diverse functions in malignancy development. However, the mechanism of aberrant overexpression of PRDX6 in CRC remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495934DOI Listing
December 2018

miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.

Cell Physiol Biochem 2018 Dec 12;51(6):2732-2745. Epub 2018 Dec 12.

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Guangdong,

Background/aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in the pathology of Parkinson's disease (PD). However, the association between potential functional polymorphisms in the SIRT2 gene and PD still needs to be identified. Exploring the molecular mechanism underlying this potential association could also provide novel insights into the pathogenesis of this disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495963DOI Listing
December 2018
1 Read

Sinoporphyrin Sodium-Mediated Sonodynamic Therapy Inhibits RIP3 Expression and Induces Apoptosis in the H446 Small Cell Lung Cancer Cell Line.

Cell Physiol Biochem 2018 Dec 14;51(6):2938-2954. Epub 2018 Dec 14.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin,

Background/aims: Sonodynamic therapy (SDT) is expected to be a new method to solve the clinical problems caused by advanced metastasis in patients with lung cancer. The use of ultrasound has the advantage of being noninvasive, with deep-penetration properties. This study explored the anti-tumor effect of SDT with a new sonosensitizer, sinoporphyrin sodium (DVDMS), on the human small cell lung cancer H446 cell line in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496045DOI Listing
December 2018

Characterization of a DNA Aptamer for Ovarian Cancer Clinical Tissue Recognition and in Vivo Imaging.

Cell Physiol Biochem 2018 Dec 11;51(6):2564-2574. Epub 2018 Dec 11.

Xiangya Hospital, Central South University, Changsha,

Backgrounds/aims: Ovarian cancer is the most lethal gynaecologic malignancy and is difficult to detect early. The inefficient early diagnosis of ovarian cancer is the main contributor to its high mortality rate. Aptamers, as chemical antibodies, are single-stranded DNA or RNA oligonucleotides that target cells or molecules with high affinity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495925DOI Listing
December 2018

Targeting PPARα for the Treatment and Understanding of Cardiovascular Diseases.

Cell Physiol Biochem 2018 Dec 12;51(6):2760-2775. Epub 2018 Dec 12.

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα, PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although the roles of these PPARs and their agonists/antagonists were defined in clinical and basic studies, the conflicting results from these studies indicate that more analysis is needed to understand the roles of PPARs. PPARα is a ligand-activated transcription factor that contributes to the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495969DOI Listing
December 2018

Risk of cancer after an acute coronary syndrome according to the type of P2Y12 inhibitor.

Thromb Res 2018 Dec 8;174:51-58. Epub 2018 Dec 8.

Cardiology Department, University Hospital Álvaro-Cunqueiro, Vigo, Spain.

Introduction: There are conflicting clinical and laboratory data about the effect of dual antiplatelet therapy (DAPT) on cancer incidence, including analysis suggesting an increased cancer risk. This study aims to analyze if there are differences in the incidence of cancer according to the type of P2Y12 inhibitor prescribed (clopidogrel, prasugrel, or ticagrelor), among a population of acute coronary syndrome (ACS) survivors treated with DAPT.

Material And Methods: A retrospective study was conducted among 4229 consecutive ACS patients discharged from a tertiary hospital with DAPT from 2010 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2018.12.014DOI Listing
December 2018

UV-light mediated green synthesis of silver and gold nanoparticles using Cornelian cherry fruit extract and their comparative effects in experimental inflammation.

J Photochem Photobiol B 2018 Dec 11;191:26-37. Epub 2018 Dec 11.

Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, 400028 Cluj-Napoca, Romania. Electronic address:

The purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy and dynamic light scattering. The modulatory effects of AgNPs-CM and AuNPs-CM on inflammation were quantified by oxidative stress parameters, pro and anti-inflammatory cytokines levels and apoptosis assessment at 2 h, 24 and 48 h after induction of inflammation with carrageenan in the paw tissue of Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2018.12.006DOI Listing
December 2018
  • Page 1 of 86239