4,410,625 results match your criteria Clinical cancer research : an official journal of the American Association for Cancer Research[Journal]


Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing

Gaming National Emergency Access Target performance using Emergency Treatment Performance definitions and emergency department short stay units.

Emerg Med Australas 2019 Apr 17. Epub 2019 Apr 17.

Sax Institute, Sydney, New South Wales, Australia.

Objective: To evaluate potential gaming of the 4 h ED length of stay metric known as the National Emergency Access Target (NEAT) in Australia and Emergency Treatment Performance (ETP) in New South Wales (NSW).

Methods: Descriptive statistical analysis was used to recalculate and compare the scores for NEAT and the NSW ETP using variations in the definitions of their measurement on 32 184 presentations during 2016. A computer simulation using a discrete event model illustrated the effect of the use of ED short stay beds on the ETP scores. Read More

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http://dx.doi.org/10.1111/1742-6723.13295DOI Listing

[Maternal Emergencies: Methodically qualified - Conclusive Treatment].

Z Geburtshilfe Neonatol 2019 Apr 17;223(2):73-84. Epub 2019 Apr 17.

Institut für Rettungs- und Notfallmedizin, Universitätsklinikum Schleswig Holstein.

Maternal emergencies can significantly affect the outcome of pregnancy and childbirth. Since obstetrical emergencies may happen at any time during pregnancy an emergency transport to a hospital nearby may not always be possible. So, obstetrical emergency-management may already become mandatory in a prehospital setting. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0762-1024
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http://dx.doi.org/10.1055/a-0762-1024DOI Listing
April 2019
1 Read

Evaluating the Effect of Monitoring through Telephone (Tele-Monitoring) on Self-Care Behaviors and Readmission of Patients with Heart Failure after Discharge.

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685167
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http://dx.doi.org/10.1055/s-0039-1685167DOI Listing
March 2019
2 Reads

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

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http://dx.doi.org/10.4414/smw.2019.20054DOI Listing

The Impact of Continuous Positive Airway Pressure upon Pleural Fluid Pressures during Thoracentesis.

Respiration 2019 Apr 17:1-5. Epub 2019 Apr 17.

University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.

Background: Excessive drop of pleural pressure (Ppl) during therapeutic thoracentesis may be related to adverse events and/or to repeated procedures due to incomplete drainage.

Objective: This was a pilot study of the impact of the application of continuous positive airway pressure (CPAP) at +5 cm H2O upon the Ppl profile during thoracentesis.

Methods: This was a prospective, controlled study of 49 consecutive adults who underwent thoracentesis. Read More

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http://dx.doi.org/10.1159/000496610DOI Listing
April 2019
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Delays in the Diagnosis and Treatment of Tuberculous Lymphadenitis in Low-Incidence Countries: A Systematic Review.

Respiration 2019 Apr 17:1-9. Epub 2019 Apr 17.

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Early detection and treatment of tuberculosis (TB) is essential to achieve the goals appointed in the WHO End TB Strategy. Tuberculous lymphadenitis (TBLA) is the most common manifestation of extrapulmonary TB, but the diagnosis can be challenging in low-incidence countries due to sparse and inconsistent clinical features, resulting in delay. We aimed to summarize and discuss the current literature on patient delay, health care delay, and total delay (i. Read More

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http://dx.doi.org/10.1159/000499052DOI Listing

Clinical Experience of Immunotherapy Treatment: Efficacy and Toxicity Analysis of the Compassionate Use Program of Nivolumab in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer.

Oncol Res Treat 2019 Apr 17;42(5):243-254. Epub 2019 Apr 17.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.

Background: Anti-PD1 monoclonal antibody nivolumab is an approved therapy option for the treatment of advanced squamous cell non-small cell lung cancer (SQ-NSCLC) patients. Data outside clinical trials about therapy efficacy and safety in later therapy line treatments have rarely been described until now.

Methods: We performed a retrospective data analysis of patients who were enrolled into the nivolu-mab Compassionate Use Program (CUP) in Germany. Read More

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http://dx.doi.org/10.1159/000499321DOI Listing

Blood Chromogranin A is Not Effective as a Biomarker for Diagnosis or Management of Bronchopulmonary NET/NET.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Identification of circulating tumor markers for clinical management in bronchopulmonary (BP) neuroendocrine tumors/neoplasms (NET/NEN) is of considerable clinical interest. Chromogranin A (CgA), a "universal" NET biomarker, is considered controversial as a circulating biomarker of BPNEN.

Aim: Assess utility of CgA in the diagnosis and management of BPNEN in a multicentric study. Read More

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http://dx.doi.org/10.1159/000500202DOI Listing

Inhibition of HSF1 enhances repressive molecular mechanisms on POMC promoter.

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Cushing´s Disease (CD) is caused by adrenocorticotropic hormone (ACTH)- secreting pituitary tumours. They express high levels of heat shock protein (HSP) 90 and heat shock factor 1 (HSF1) in comparison to the normal tissue counterpart, indicating activated cellular stress.

Aims: (1) to correlate HSF1 expression with clinical features and hormonal/radiological findings of CD and (2) to investigate the effects of HSF1 inhibition as a target for CD treatment. Read More

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http://dx.doi.org/10.1159/000500200DOI Listing

Development and Validation of Molecular Assays for Limited Tissue Samples.

Acta Cytol 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

As the value of molecular testing of cancer specimens increases, the number of tests imposed on tumor specimens also increases, often in tension with the amount of tumor material available. To develop and validate molecular assays for limited specimens, there are specific concerns that must be addressed, including DNA quality, quantity, and abundance; the number of targets/ability to multiplex; and the analytical sensitivity and specificity of the assay itself. Ultimately, weighing these considerations during assay validation in the overall context of clinical utility and laboratory workflow is critical for delivering the highest level of personalized care to patients. Read More

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http://dx.doi.org/10.1159/000499109DOI Listing

Measuring Quality of Life in the Speaker with Dysarthria: Reliability and Validity of the European Portuguese Version of the QoL-DyS.

Folia Phoniatr Logop 2019 Apr 17:1-15. Epub 2019 Apr 17.

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Background: The impact of acquired dysarthria on the person's life and social participation is well recognized and is the key to the process of rehabilitation. Evaluation of the effectiveness of an intervention that addresses this impact is a challenge for clinicians and researchers.

Objectives: The purpose of this study was to evaluate the validity and reliability of the European Portuguese version of the Quality of Life in the Speaker with Dysarthria (QoL-DyS). Read More

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http://dx.doi.org/10.1159/000495564DOI Listing

The Mealtime Assessment Scale (MAS): Part 2 - Preliminary Psychometric Analysis.

Folia Phoniatr Logop 2019 Apr 17:1-12. Epub 2019 Apr 17.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: The Mealtime Assessment Scale (MAS) was developed to assess swallowing safety and efficacy during the meal. The study aims to perform a preliminary validation of MAS by investigating internal consistency, inter-rater agreement, concurrent and known-group validity, and responsiveness.

Methods: MAS was tested on 100 persons without dysphagia (group 1) and 100 persons with dysphagia (group 2). Read More

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http://dx.doi.org/10.1159/000494136DOI Listing

The Effect of Gonadotropin-Releasing Hormone Analogue on Final Adult Height in Children with Idiopathic Short Stature.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objective: Assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa).

Methods: All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2-3, who achieved their final adult height (FAH) between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH and, mid-parental height of 28 children with ISS who received GnRHa treatment for 1. Read More

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http://dx.doi.org/10.1159/000499929DOI Listing
April 2019
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Staphylococcus aureus and Host Immunity in Recurrent Furunculosis.

Dermatology 2019 Apr 17:1-11. Epub 2019 Apr 17.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis. Read More

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http://dx.doi.org/10.1159/000499184DOI Listing

De novo Cardiac Valve Calcification after Hemodialysis in End-Stage Renal Disease Patients Predicts Future Cardiovascular Events: A Longitudinal Cohort Study.

Cardiorenal Med 2019 Apr 17;9(4):229-239. Epub 2019 Apr 17.

Renal Division, Department of Internal Medicine, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Background: Cardiac valve calcification (CVC) in maintenance hemodialysis patients is associated with adverse cardiovascular outcomes. However, whether de novo CVC in incident hemodialysis patients predicts future cardiovascular events is unknown.

Methods: This study included 174 patients newly receiving hemodialysis without CVC as reflected by echocardiography between January 2005 and December 2014. Read More

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http://dx.doi.org/10.1159/000494701DOI Listing

Diffuse Coronary Artery Fistula Leading to Syncope and Treated by Transcatheter Coil Occlusion and a Defibrillator: A Case Report.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: Coronary artery fistulas connecting coronary arteries to cardiac cavities are rare but clinically significant anomalies.

Clinical Presentation And Intervention: A 47-year-old male patient presented with syncope. Left ventricular dysfunction was detected on echocardiography. Read More

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http://dx.doi.org/10.1159/000500309DOI Listing

Ultrasound-Guided Continuous Femoral Nerve Block with Dexmedetomidine Combined with Low Concentrations of Ropivacaine for Postoperative Analgesia in Elderly Knee Arthroplasty.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: This study aims to investigate the clinical effect of dexmedetomidine (DEX) combined with low concentrations of ropivacaine in ultrasound-guided continuous femoral nerve block for postoperative analgesia in elderly patients with total knee arthroplasty (TKA).

Materials And Methods: Patients were divided into three groups: group C, group D1 and group D2. For postoperative analgesia, patients in group C were given 0. Read More

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http://dx.doi.org/10.1159/000500261DOI Listing

Coronally Repositioned Flap with Bioresorbable Collagen Membrane for Miller's Class I and II Recession defects - A Case Series.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objective: Gingival recession is one of the most common aesthetic and functional concerns associated with periodontal tissues. Several techniques have been described in order to cover the exposed root surface. The aim of the present study was to evaluate the efficacy of recession coverage using coronally repositioned flap in conjunction with bioresorbable collagen membrane. Read More

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http://dx.doi.org/10.1159/000500308DOI Listing

Localization of liver lesions in abdominal CT imaging: II. Mathematical model observer performance correlates with human observer performance for localization of liver lesions in abdominal CT imaging.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA, Rochester, Minnesota, UNITED STATES.

Purpose: Determination of the effect of protocol modifications on diagnostic performance in CT with human observers is extremely time-consuming, limiting the applicability of such methods in routine clinical practice. In this work, we sought to determine whether a channelized Hotelling observer (CHO) could predict human observer performance for the task of liver lesion localization as background, reconstruction algorithm, dose, and lesion size were varied. Materials and Methods: Liver lesions (5mm, 7mm, and 9mm) were digitally inserted into the CT projection data of patients with normal livers and water phantoms. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a62DOI Listing

ADAM phantom to test 4D medical imaging and dose delivery devices.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Agricultural, Food and Forestry System, Universita di Firenze, Florence, ITALY.

Radiotherapy treatment of moving lesions is a challenging task in which different strategies can be used. The clinical implementation of the variety of complex technical solutions pursued to treat cancer, while sparing healthy tissues, requires accurate quality assurance tests and adequate phantoms. The aim of this work is to report on the Anthropomorphic Dynamic breAthing Model (ADAM) and on its applications to test image quality and dose delivery for four-dimensional (4D) techniques used to compensate for breathing-induced tumor motion. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1a49
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http://dx.doi.org/10.1088/1361-6560/ab1a49DOI Listing
April 2019
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Localization of liver lesions in abdominal CT imaging: I. Correlation of human observer performance between anatomical and uniform backgrounds.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA, Rochester, UNITED STATES.

Purpose: The purpose of this study was to determine the correlation between human observer performance for localization of small low contrast lesions within uniform water background versus an anatomical liver background, under the conditions of varying dose, lesion size, and reconstruction algorithm. Materials and Methods: Liver lesions (5mm, 7mm, and 9mm, contrast: -21HU) were digitally inserted into CT projection data of 10 normal patients in vessel-free liver regions. Noise was inserted into the projection data to create three image sets: full dose and simulated half and quarter doses. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a45DOI Listing

Considerations for mood and emotion measures in mindfulness-based intervention research.

Curr Opin Psychol 2019 Feb 8;28:279-284. Epub 2019 Feb 8.

Departments of Psychiatry and Medicine, University of Massachusetts Medical School, Worcester, MA 06155, USA.

A large and growing body of work has examined the effects of Mindfulness-Based Interventions (MBI's), such as Mindfulness-Based Stress Reduction and Mindfulness-Based Cognitive Therapy, on emotion-related outcomes, both in mental health settings and general populations. These studies vary widely in the approach to measurement of emotion-related measurements after MBI's. A systematic review of randomized clinical trials of MBIs was conducted with a focus on identifying what emotion-related assays were able to detect changes with MBI's, including scales and instruments (both self-report and clinician-rated) on constructs such as depression, anxiety, emotion regulation, and other mood states. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2352250X183023
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http://dx.doi.org/10.1016/j.copsyc.2019.02.001DOI Listing
February 2019
1 Read

Quantitation of vitamin K1 in serum using online SPE-LC-MS/MS and the challenges of working with vitamin K.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 7;1117:41-48. Epub 2019 Apr 7.

Department of Clinical Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark.

Vitamin K1 (phylloquinone) is one of the vitamin Ks. Several studies have previously investigated the role of vitamin K1 status in respect to disease, but without consistent results. Since vitamin K deficiency has been associated with different disease states it is important to develop a biochemical analysis with sufficient sensitivity and a low limit of quantitation (LOQ). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183176
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http://dx.doi.org/10.1016/j.jchromb.2019.04.010DOI Listing
April 2019
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Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review.

Eur J Med Chem 2019 Apr 10;173:117-153. Epub 2019 Apr 10.

School of Chemistry, Chemical Engineering and Life Science, School of Materials Science and Engineering, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address:

At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.063DOI Listing

Complications in staged late titanium cranioplasty and ventriculoperitoneal shunting for traumatic brain injury patients.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Zhongshan city people's hospital, Zhongshan, Guangdong, China.

Background: Hydrocephalus is a common complication following decompressive craniectomy (DC). Ventriculoperitoneal shunt (VPS) was required for some patients before receiving cranioplasty (CP). Presence of a VPS is regarded as a risk factor for overall CP complications. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.079DOI Listing

Transcavernous Transclinoidal Half-and-Half Approach for Clipping of a Twice Recurrent Stent-Coiled Giant Basilar Tip Aneurysm: A 3D Surgical Video.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurological Surgery, University of Miami MILLER School of Medicine, 1095 NW 14th Terrace (D4-6), Miami, FL 33136 USA University Of Miami, Department of Neurological Surgery.

The authors present a 3D surgical video of a half and half, trans-cavernous approach for microsurgical clipping of a giant basilar tip aneurysm that recurred twice after endovascular treatment. The case refers to a 60 year-old man who presented with subarachnoid hemorrhage and was treated with coiling and with a good clinical and radiographic outcome. At three months, he was found to have recurrent filling at the neck of the aneurysm, and was treated again endovascularly with stent coiling. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.045DOI Listing

A microanatomical study of the far lateral approach.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China. Electronic address:

Objetive: The far-lateral approach (FLA) remains a challenge for neurosurgeons due to the complex anatomy of this region, especially in patients with anatomical variations. There is therefore an urgent need for better quantitative knowledge of the microsurgical anatomy of the FLA.

Methods: The study was performed using the dried skulls and atlas vertebrae of 50 Chinese adults, in which significant clinical parameters were measured. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.004DOI Listing

Seed-based connectivity analysis of resting-state fMRI in patients with brain tumors: a practical approach.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

International Neuroscience Institute, Rudolf-Pichlmayr-Straße 4, D - 30625 Hannover, Germany; Leibniz Institute, Germany.

Objective: In this study, we are presenting our experience using resting state functional magnetic resonsce imaging (rs-fMRI) in preoperative planning. We performed goup analysis to demonestrate the effects of brain tumor on resting state networks (RSNs) METHODS: Thirty patients with supratentorial gliomas were included in the study. Preoperative rs-fMRI and structural MRI were performed in all cases. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.073DOI Listing

Meta-analysis of the prognosis of Different treatments of symptomatic moyamoya disease.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China; Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, 30052China. Electronic address:

Objective: The purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with MMD to choose the appropriate treatment.

Methods: We comprehensively searched PubMed, Embase, Web of Science and the Cochrane Library for the articles published regarding MMD treatment. If the I value, which evaluated the heterogeneity, was less than 50%, a fixed effect model was used; if not, a random effect model was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.062DOI Listing

Preoperative and histological predictors of recurrence and survival in atypical meningioma after initial gross total resection.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 10029. Electronic address:

Objective: Atypical (WHO grade II) meningiomas (AM) are associated with a substantial risk for recurrence even following a complete, gross total resection (GTR). The present study aimed to evaluate clinical and AM tumor histopathological features that may predict risk of recurrence and survival within this patient population.

Methods: 72 consecutive patients and corresponding tumor specimens who received a primary GTR for an AM from 2007-2016 at a single institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.069DOI Listing

Carotid sinus nerve: a comprehensive review of its anatomy, variations, pathology, and clinical applications.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Seattle Science Foundation, Seattle, WA, USA; Department of Anatomical Sciences, St. George's University, St. George's, Grenada, West Indies.

The carotid sinus nerve branches off the glossopharyngeal nerve just after its appearance from the jugular foramen, descends along the internal carotid artery, and enters the carotid sinus. There have been many studies of the pathway and the course of the carotid sinus nerve and its communications with surrounding nerves. The intercommunication is exceedingly complicated. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.064DOI Listing

Association of admission serum glucose-phosphate ratio with severity and prognosis of aneurysmal subarachnoid hemorrhage.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing, 210008 Jiangsu Province PR China. Electronic address:

Background: and Purpose Serum hyperglycemia and hypophosphatemia were reported to be common in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study was aimed to explore whether admission serum glucose-phosphate ratio was associated with the severity and prognosis of aSAH.

Methods: We retrospectively analyzed 198 patients with aSAH who were admitted within 24 hours of hemorrhage occurrence to a single academic hospital from June 2016 to September 2017. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.071DOI Listing

Safety and Feasibility Assessment of the O-arm as an Intraoperative Angiography Device in Aneurysm Surgery: Technical Note.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurological Surgery; Hospital Clinic de Barcelona, University of Barcelona.

Objective: To describe the technique and initial experience using a rotational 3D fluoroscopy system (O-arm, Medtronic) as intraoperative angiography (IA) in the surgery of cerebral aneurysms.

Methods: The 3D IA with O-arm (IAWOA) was performed in a consecutive cohort of patients with unruptured intracranial aneurysms. Conventional microsurgical clipping was performed with the assistance of indocyanine green videoangiography (ICGVA). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.076DOI Listing

Tailor-made branch reconstruction by intracranial to intracranial bypass during clipping surgery for middle cerebral artery aneurysms.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: In clipping surgery, it is advantageous to dissect an adhered artery from the aneurysmal dome to achieve complete clipping. Bypass surgery is useful to reconstruct an adhered artery when dissection of the artery is technically difficult or risky. Here, we report the effectiveness of tailor-made intracranial (IC)-IC bypass to reconstruct an adhered artery in clipping surgery for middle cerebral artery (MCA) aneurysms. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.074DOI Listing

Cytotoxic effect of aqueous ethanolic extract of Luffa cylindrica leaves on cancer stem cells CD44/24 in breast cancer patients with various molecular sub-types using tissue samples in vitro.

J Ethnopharmacol 2019 Apr 14:111877. Epub 2019 Apr 14.

Medical Research Department, National Institute of Occupational Safety and Health, Egypt. Electronic address:

Ethnopharmacological Relevance: Luffa cylindrica (L.) M.Roem is a climbing plant its parts have been used as traditional medicine for the treatment of different types of diseases including diarrhea, inflammation, cancer and viral infections. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111877DOI Listing

CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.

Biochimie 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China. Electronic address:

Cell cycle-related and expression elevated protein in tumor (CREPT) is emerging as a novel cancer-related gene that is dysregulated in many kinds of malignancies. However, the expression and biological role of CREPT in glioma remains unclear. In the present study, we aimed to explore the potential function and regulation mechanism of CREPT in glioma. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.04.014DOI Listing

Evoked potentials improve multimodal prognostication after cardiac arrest.

Resuscitation 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Aim: Predicting recovery in comatose post-cardiac arrest patients requires multiple modalities of prognostic assessment. In isolation, absent N20 cortical responses in somatosensory evoked potentials (SSEPs) are a specific predictor of poor outcome. It is unknown whether SSEP results, when assessed in the context of prior knowledge (demographic and clinical information), change the pretest predicted probability of recovery. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.011DOI Listing

Optimal oxygenation and role of free radicals in PPHN.

Free Radic Biol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USA. Electronic address:

Effective ventilation of the lungs is essential in mediating pulmonary vasodilation at birth to allow effective gas exchange and an increase in systemic oxygenation. Unsuccessful transition prevents the increase in pulmonary blood flow after birth resulting in hypoxemia and persistent pulmonary hypertension of the newborn (PPHN). Management of neonates with PPHN includes ventilation of the lungs with supplemental oxygen to correct hypoxemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193023
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.001DOI Listing
April 2019
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Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Non-invasive Multi-modal Methods to Differentiate Inflamed vs Fibrotic Strictures in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Apr 14. Epub 2019 Apr 14.

IBD Centre, Humanitas Clinical and Research Centre, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy. Electronic address:

Fibrotic strictures occur in 30% of patients with Crohn's disease (CD). However, there are no therapeutic agents that prevent or reverse fibrotic strictures. Strictures are treated by endoscopic dilatation procedures and surgical procedures, but there are high rates of recurrence. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.025DOI Listing

Update on ERbeta.

J Steroid Biochem Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States.

ERbeta (ERβ) celebrated its 20th birthday in 2016 and although the overwhelming data in the literature indicate a role for this receptor in the control of epithelial proliferation, neurodegeneration and immune function, no ERβ agonists have yet made it to the clinics. This is the situation, despite the fact that very good safe ERβ agonists have been synthesized and at least one has been donated to the NIH for distribution to researchers, who want to study its possible clinical use. Clinical trials are ongoing for the use of ERβ agonists in prostate cancer and schizophrenia but even today reviewers of our grants still make comments like "The grant is excellent except that the focus of the grant is ERβ". Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.007DOI Listing

'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

Osteoarthritis Cartilage 2019 Apr 14. Epub 2019 Apr 14.

Clinical Epidemiology, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, UK. Electronic address:

Objective: To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Design: Adults aged ≥45 years with a recent primary care consultation for knee OA/arthralgia completed a daily pen-and-paper diary for up to 3 months, including questions on average knee pain intensity, pain descriptors, other symptoms, activity interference, and selected physical exposures (prolonged kneeling, squatting, climbing stairs, ladders, and moving/lifting heavy objects). Informed by a systematic review, flare-ups were defined a priori. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.003DOI Listing

The photo-activated and photo-thermal effect of the 445/970 nm diode laser on the mixed biofilm inside root canals of human teeth in vitro: a pilot study.

Photodiagnosis Photodyn Ther 2019 Apr 14. Epub 2019 Apr 14.

Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000, Zagreb, Croatia. Electronic address:

Aims: 1) Evaluation of the photo-thermal (PT) and photo-activated (PAD) antibacterial effect of the 445/970 nm diode laser on E. faecalis, S. aureus and C. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.014DOI Listing

Therapeutic Approaches To Enhance PINK1/Parkin Mediated Mitophagy For The Treatment Of Parkinson's Disease.

Neurosci Lett 2019 Apr 14. Epub 2019 Apr 14.

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, Scotland.

The discovery of rare familial monogenic forms of early-onset Parkinson's disease has led to the identification of a mitochondrial quality control process as a key player in this disease. Loss-of-function mutations in the genes encoding PINK1 or Parkin result in insufficient removal of dysfunctional mitochondria through autophagy, a process termed mitophagy. Understanding the mechanism of this process and the function of its two key players, PINK1 and Parkin, has led to the discovery of new therapeutic approaches. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.029DOI Listing

Anesthesia for pediatric ophthalmologic surgery.

J AAPOS 2019 Apr 14. Epub 2019 Apr 14.

Department of Anesthesiology, California Pacific Medical Center, Sutter Hospitals, Northern California Anesthesia Physicians, San Francisco, California.

This review presents updated recommendations, based on existing clinical research, for anesthetic management of strabismus surgery in children. In children, unlike adults, eye surgery nearly always requires general anesthesia, even for brief procedures. Recommendations for preoperative anxiolysis, fasting guidelines, and management of upper respiratory infections are discussed. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.10.017DOI Listing

Poisoning associated with the use of mushrooms: A review of the global pattern and main characteristics.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Laboratory of Toxicology, University of Crete, Voutes, Heraklion, Crete, 71003, Greece.

Worldwide, special attention has been paid to wild mushrooms-induced poisoning. This review article provides a report on the global pattern and characteristics of mushroom poisoning and identifies the magnitude of mortality induced by mushroom poisoning. In this work, reasons underlying mushrooms-induced poisoning, and contamination of edible mushrooms by heavy metals and radionuclides, are provided. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915193021
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http://dx.doi.org/10.1016/j.fct.2019.04.016DOI Listing
April 2019
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Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ aggregation.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50 - 50134, Florence, Italy; Interuniversity Center for the Study of Neurodegenerative Diseases (CIMN), Florence, Italy. Electronic address:

Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ fibrillation, a main histopathological feature of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.015DOI Listing

Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options.

Neurosci Biobehav Rev 2019 Apr 14. Epub 2019 Apr 14.

Island Medical Program, University of British Columbia, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada. Electronic address:

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), and has a significant impact on the increasing burden of these neuropathologies. Over the past decades, some of the pathophysiological and molecular mechanisms that contribute to these diseases have been elucidated and these findings indicate that, despite presenting distinct features, there are several similarities between the neurobiological alterations that lead to MDD and neurodegeneration in AD, PD and HD. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.002DOI Listing
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