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    1333 results match your criteria Clinical breast cancer[Journal]

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    Prognostic Influence of Tumor Stroma on Breast Cancer Subtypes.
    Clin Breast Cancer 2017 Aug 19. Epub 2017 Aug 19.
    Unidad de Investigación, Fundación Hospital de Jove, Gijón, Spain; Servicio de Cirugía, Fundación Hospital de Jove, Gijón, Spain. Electronic address:
    Introduction: The objective of the present work was to evaluate the impact of the phenotype of both intratumoral mononuclear inflammatory cells (MICs) and cancer-associated fibroblast (CAFs), assessed as to their expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) on prognosis in different breast cancer subtypes.

    Materials And Methods: A total of 247 tumors of patients with primary ductal invasive breast cancer were categorized into 1 of 4 major subtypes, using the 3 standard immunohistochemical markers (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor/Neu 2 [HER2] receptor status). An immunohistochemical study was performed using tissue arrays and specific antibodies against MMP-9, MMP-11, and MMP-14, and TIMP-1 and TIMP-2. Read More

    Assessing Changes in the Activity Levels of Breast Cancer Patients During Radiation Therapy.
    Clin Breast Cancer 2017 Aug 24. Epub 2017 Aug 24.
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA.
    Background: Radiation therapy (RT) is often delivered after lumpectomy for women with breast cancer. A common perceived side effect of RT is fatigue, yet its exact effect on activity levels and sleep is unknown. In this study we analyzed the change in activity levels and sleep using an activity tracking device before, during, and after RT for women with early stage breast cancer and ductal carcinoma in situ who underwent adjuvant RT. Read More

    Stromal Clusterin Expression Predicts Therapeutic Response to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer.
    Clin Breast Cancer 2017 Aug 19. Epub 2017 Aug 19.
    Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, RI.
    Background: Expression of clusterin correlates with tumor progression and therapeutic response in several human malignancies, including breast cancer. However, its predictive value in the neoadjuvant setting in breast cancer remains unexplored. The objective of this explorative study was to determine whether clusterin expression in breast cancer correlated with clinical pathologic characteristics and whether its expression was predictive of response to neoadjuvant chemotherapy (NAC). Read More

    Evaluation of the Tumor Response After Neoadjuvant Chemotherapy in Breast Cancer Patients: Correlation Between Dynamic Contrast-enhanced Magnetic Resonance Imaging and Pathologic Tumor Cellularity.
    Clin Breast Cancer 2017 Aug 18. Epub 2017 Aug 18.
    Department of Radiology and Research, Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:
    Background: We evaluated the tumor response after neoadjuvant chemotherapy (NAC) in breast cancer patients using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging parameters assessed using a commercially available computer-aided system. We also analyzed their correlation with pathologic tumor cellularity.

    Materials And Methods: We retrospectively reviewed the data from 130 patients with breast cancer who had undergone NAC followed by surgery from January to October 2013. Read More

    Radiomics Analysis on Ultrasound for Prediction of Biologic Behavior in Breast Invasive Ductal Carcinoma.
    Clin Breast Cancer 2017 Aug 18. Epub 2017 Aug 18.
    Department of Ultrasound, Fudan University Shanghai Cancer Center, Shanghai, China.
    Introduction: In current clinical practice, invasive ductal carcinoma is always screened using medical imaging techniques and diagnosed using immunohistochemistry. Recent studies have illustrated that radiomics approaches provide a comprehensive characterization of entire tumors and can reveal predictive or prognostic associations between the images and medical outcomes. To better reveal the underlying biology, an improved understanding between objective image features and biologic characteristics is urgently required. Read More

    Treatment Outcomes and Prognostic Factors in Male Patients With Stage IV Breast Cancer: A Population-based Study.
    Clin Breast Cancer 2017 Aug 10. Epub 2017 Aug 10.
    Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX. Electronic address:
    Purpose: Male breast cancer (MBC) represents < 1% of breast cancer patients, and limited data exists regarding metastatic MBC. To better characterize this patient subset, we performed a population-based study examining prognostic factors among patients with stage IV MBC.

    Methods: Patients with stage IV MBC diagnosed between 1988 and 2012 were selected from the Surveillance, Epidemiology, and End Results database. Read More

    Predicting Brain Metastasis in Breast Cancer Patients: Stage Versus Biology.
    Clin Breast Cancer 2017 Aug 18. Epub 2017 Aug 18.
    Department of Clinical Oncology, Cairo University Hospital, Cairo, Egypt; Cairo Oncology Center (Cairocure), Cairo, Egypt. Electronic address:
    Background: Brain metastasis (BM) is a life-threatening event in breast cancer patients. Identifying patients at a high risk for BM can help to adopt screening programs and test preventive interventions. We tried to identify the incidence of BM in different stages and subtypes of breast cancer. Read More

    Reliability of Self-reported Treatment Data by Patients With Breast Cancer Compared With Medical Record Data.
    Clin Breast Cancer 2017 Aug 18. Epub 2017 Aug 18.
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
    Objectives: Medical records are considered the gold standard for accurate treatment information. However, treatment data are increasingly obtained from questionnaires. It can be questioned whether self-reported treatment data are reliable, particularly because patients have to process a lot of information during their diagnosis and treatment process. Read More

    Improved Performance of Adjunctive Ultrasonography After Mammography Screening for Breast Cancer Among Chinese Females.
    Clin Breast Cancer 2017 Aug 15. Epub 2017 Aug 15.
    Department of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. Electronic address:
    Introduction: Until now, no studies have investigated whether women other than those with dense breasts are suitable for adjunctive ultrasonography after negative mammography, and investigated whether all women with negative mammography are suitable for adjunctive ultrasonography.

    Methods: Based on the Multi-modality Independent Screening Trial in China, a total of 31,918 women aged 45 to 65 years underwent both ultrasonography and mammography. Physicians performed ultrasonography and mammography separately and were blinded to each other's findings until their interpretations had been recorded. Read More

    Correlation of MYC Gene and Protein Status With Breast Cancer Subtypes and Outcome of Patients Treated With Anthracycline-Based Adjuvant Chemotherapy. Pooled Analysis of 2 Hellenic Cooperative Group Phase III Trials.
    Clin Breast Cancer 2017 Jul 13. Epub 2017 Jul 13.
    Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece; Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: The prognostic/predictive value of aberrant MYC gene copies and protein expression is not clear in breast cancer.

    Patients And Methods: Early breast cancer patients were treated with anthracycline-containing chemotherapy within 2 randomized adjuvant trials. MYC gene and centromere-8 status, as well as Myc protein expression were investigated on 1060 paraffin tumors with fluorescence in situ hybridization and immunohistochemistry, respectively. Read More

    Changing Natural History of HER2-Positive Breast Cancer Metastatic to the Brain in the Era of New Targeted Therapies.
    Clin Breast Cancer 2017 Aug 9. Epub 2017 Aug 9.
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:
    Background: Given the wide adoption of human epidermal growth factor receptor 2 (HER2)-targeted therapies for advanced HER2-positive breast cancer, we studied the natural history of patients with HER2-positive breast cancer brain metastases (BCBM) over time.

    Patients And Methods: Patients with HER2-positive BCBM identified from a prospectively maintained database at the University of North Carolina were divided into 3 cohorts by year of BCBM diagnosis. Cohorts were selected by year of HER2-targeted therapy US Food and Drug Administration approval. Read More

    Use of Breast Magnetic Resonance Imaging and Ultrasonography for Identifying Nonpalpable Axillae Metastases in Newly Diagnosed Breast Cancer Patients.
    Clin Breast Cancer 2017 Aug 9. Epub 2017 Aug 9.
    Department of Radiology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China. Electronic address:
    Background: The metastasis of axillary lymph node (ALNs) is a critical step in the initial cancer staging of newly diagnosed breast cancer (BC) patients. Various imaging modalities can enhance the sensitivity of clinical examination in assessing the ALN status.

    Patients And Methods: We enrolled 135 patients with BC, confirmed via histopathology, including 4 bilateral BC cases. Read More

    Discrepancies Between Pathological Tumor Responses and Estimations of Complete Response by Magnetic Resonance Imaging After Neoadjuvant Chemotherapy Differ by Breast Cancer Subtype.
    Clin Breast Cancer 2017 Jul 21. Epub 2017 Jul 21.
    Department of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
    Introduction: The influence of breast cancer (BC) subtype in discrepancies between pathologic complete response (pCR) and complete response by magnetic resonance imaging (MRI-CR) after neoadjuvant chemotherapy (NAC) have not been discussed well. We evaluated the association between BC subtype and pCR or only residual in situ lesion without invasive cancer (pCR/in situ(+)) in patients with MRI-CR (positive predictive value [PPV]).

    Material And Methods: From the data of 716 patients with primary BC who were diagnosed with invasive cancer and treated with NAC and then surgery from January 2009 to May 2014 at St. Read More

    RESILIENCE: Phase III Randomized, Double-Blind Trial Comparing Sorafenib With Capecitabine Versus Placebo With Capecitabine in Locally Advanced or Metastatic HER2-Negative Breast Cancer.
    Clin Breast Cancer 2017 May 22. Epub 2017 May 22.
    The West Clinic, Memphis, TN.
    Introduction: Sorafenib is a multikinase inhibitor with antiangiogenic/antiproliferative activity. In this randomized, double-blind, placebo-controlled phase III trial, we assessed first- or second-line capecitabine with sorafenib or placebo in patients with locally advanced/metastatic HER2-negative breast cancer resistant to a taxane and anthracycline and with known estrogen/progesterone receptor status.

    Patients And Methods: A total of 537 patients were randomized to capecitabine 1000 mg/m(2) orally twice per day for days 1 to 14 every 21 days with oral sorafenib 600 mg/d or placebo. Read More

    Indications for Postmastectomy Radiation After Neoadjuvant Chemotherapy in ypN0 and ypN1-3 Axillary Node-Positive Women.
    Clin Breast Cancer 2017 Aug 1. Epub 2017 Aug 1.
    Department of Preventive and Restorative Dental Sciences, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
    Introduction: Downstaging with neoadjuvant chemotherapy (NAC) might obscure indications for postmastectomy radiation (PMRT). The degree of downstaging that results in local-regional recurrence (LRR) rates low enough to omit PMRT remains controversial. We examined the rate of LRR in women who received NAC who underwent mastectomy without PMRT. Read More

    Progression-Free Survival and Time to Progression as Real Surrogate End Points for Overall Survival in Advanced Breast Cancer: A Meta-Analysis of 37 Trials.
    Clin Breast Cancer 2017 Jul 25. Epub 2017 Jul 25.
    Department of Integrated Traditional and Western Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:
    Background: Progression-free survival (PFS) and time to progression (TTP) have been reported to correlate with overall survival (OS) in several cancer types. To our knowledge, however, the correlation between them is unclear.

    Methods: A literature-based meta-analysis was performed to assess whether PFS and TTP can be considered reliable surrogate end points for OS in a phase 3 clinical trial of advanced breast cancer (ABC). Read More

    The Effect of Receptor Status on Mastectomy and Contralateral Prophylactic Mastectomy Rates in Early Stage Invasive Breast Carcinoma.
    Clin Breast Cancer 2017 Jun 29. Epub 2017 Jun 29.
    Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA.
    Background: There is an established relationship between hormone receptor (HR; estrogen and/or progesterone receptors) status, HER2 status, and locoregional recurrence. The purpose of this study was to analyze how HR and HER2 receptor status have influenced the surgical management trends among patients with early stage breast cancer.

    Patients And Methods: The National Cancer Database was queried for patients with cT1 to cT3, cN0, and cM0 breast carcinoma from 2004 to 2012. Read More

    Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T-Systematic Review and Meta-analysis.
    Clin Breast Cancer 2017 Jul 5. Epub 2017 Jul 5.
    Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
    Introduction: We compared the diagnostic performance of diffusion weighted imaging (DWI) acquired with 1.5T and 3.0T magnetic resonance (MR) units in differentiating malignant breast lesions from benign ones. Read More

    How Young Is Too Young in Breast Cancer?-Young Breast Cancer Is Not a Unique Biological Subtype.
    Clin Breast Cancer 2017 Jun 8. Epub 2017 Jun 8.
    Department of Oncology, Zhejiang University Jinhua Hospital, Zhejiang Province, China.
    Background: There is no uniformly adopted cutoff value to define "young patients" with breast cancer. This study was designed to determine an optimal cutoff value, to investigate prognostic factors and to explore gene expression profiles of young female breast cancer.

    Materials And Methods: The Surveillance, Epidemiology, and End Results database was examined to identify cases of female breast cancer diagnosed between 2000 and 2007. Read More

    Alarming Burden of Triple-negative Breast Cancer in India.
    Clin Breast Cancer 2017 Jul 20. Epub 2017 Jul 20.
    Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India. Electronic address:
    Breast cancer is the most prevalent cancer among women worldwide. Among the different breast cancer subtypes, triple-negative breast cancer (TNBC), which is more prevalent among younger age women, is the most aggressive form. Numerous clinicopathologic studies performed throughout the world strongly support the utterly poor prognoses and high recurrence rate of TNBC. Read More

    Pregnancy Outcomes After a Breast Cancer Diagnosis: A Systematic Review and Meta-analysis.
    Clin Breast Cancer 2017 Jul 10. Epub 2017 Jul 10.
    Kids Cancer Centre, Sydney Children's Hospital, Sydney, School of Women's and Children's Health, Discipline of Paediatrics, UNSW Medicine, University of New South Wales, and Nelune Comprehensive Cancer Centre, Prince of Wales Hospital, Sydney, NSW, Australia. Electronic address:
    Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. Read More

    Patterns of Fractionation and Boost Usage in Adjuvant External Beam Radiotherapy for Ductal Carcinoma in Situ in the United States.
    Clin Breast Cancer 2017 Jun 29. Epub 2017 Jun 29.
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO. Electronic address:
    Background: While the roles of hypofractionated (HFxn) radiotherapy and lumpectomy boost in the adjuvant management of invasive breast cancer are supported by the results of clinical trials, randomized data supporting their use for ductal carcinoma in situ (DCIS) are forthcoming. We sought to evaluate current national trends and identify factors associated with HFxn and boost usage using the National Cancer Database.

    Patients And Methods: We queried the National Cancer Database for women diagnosed with DCIS from 2004 to 2014 undergoing external beam radiotherapy after breast conservation surgery. Read More

    Refusal of Cancer-Directed Surgery by Breast Cancer Patients: Risk Factors and Survival Outcomes.
    Clin Breast Cancer 2017 Jul 18. Epub 2017 Jul 18.
    Second Department of Surgery, Democritus University of Thrace Medical School, Alexandroupoli, Greece.
    Background: It has been reported that some patients with breast cancer may refuse cancer-directed surgery, but the incidence in the United States is not currently known. The purpose of this study was to identify the incidence, trends, risk factors, and eventual survival outcomes associated with refusal of recommended breast cancer-directed surgery.

    Patients: A retrospective review of the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2013 was performed. Read More

    Determinants of Last-line Treatment in Metastatic Breast Cancer.
    Clin Breast Cancer 2017 Jul 14. Epub 2017 Jul 14.
    Department of Medicine (DAME), University of Udine, Udine, Italy; Department of Clinical Oncology, CRO Aviano National Cancer Institute, Aviano, Italy. Electronic address:
    Background: In metastatic breast cancer (MBC) patients, the identification of factors helping clinicians in the choice between active therapy versus best supportive care is needed clinically. The aim of the present study was to identify the clinicopathologic factors that could improve the prognostic valuation of MBC patients and clinical decision-making at the end of life.

    Patients And Methods: The present study analyzed data from a retrospective series of 522 MBC patients treated at the oncology department (University Hospital of Udine) from January 2004 to June 2014. Read More

    Breast Cancer Epidemiology in Gulf Cooperation Council Countries: A Regional and International Comparison.
    Clin Breast Cancer 2017 Jul 13. Epub 2017 Jul 13.
    Medical Radiation Sciences, Medical Image Optimization and Perception Group, University of Sydney, Faculty of Health Sciences, Sydney, NSW, Australia.
    Breast cancer is the most frequently diagnosed noncutaneous malignancy in women living in Gulf Cooperation Council countries. The present report aimed to highlight the similarities and variations in breast cancer incidence, age at diagnosis, clinicopathologic features, molecular characteristics, and lifestyle factors that contribute to an increasing incidence of breast cancer compared with neighboring Arab and westernized countries. The data presented, although having important implications for policy makers, also highlights the need for further research. Read More

    Ixabepilone and Carboplatin for Hormone Receptor Positive/HER2-neu Negative and Triple Negative Metastatic Breast Cancer.
    Clin Breast Cancer 2017 Jul 10. Epub 2017 Jul 10.
    US Oncology Research, McKesson Specialty Health, The Woodlands, TX; Texas Oncology, Baylor-Sammons Cancer Center, Dallas, TX.
    Background: Hormonal therapies and single-agent sequential chemotherapeutic regimens are the standards of care for HER2(-) metastatic breast cancer (MBC). However, treating patients with hormone-refractory and triple negative (TN) MBC remains challenging. We report the results of combined ixabepilone and carboplatin in a single-arm phase II trial. Read More

    Lobular Metastatic Breast Cancer Patients With Gastrointestinal Involvement: Features and Outcomes.
    Clin Breast Cancer 2017 Jul 10. Epub 2017 Jul 10.
    Division of Medical Senology, European Institute of Oncology, Milan, Italy.
    Introduction: Metastatic breast cancer typically involves the lungs, bones, brain, and liver and only occasionally affects the gastrointestinal (GI) tract. The relevant published data have been limited to case reports and small series of patients.

    Patients And Methods: The present study focused on the treatment and outcomes of breast cancer patients with GI involvement diagnosed at the European Institute of Oncology. Read More

    Validation of a Novel Diagnostic Kit Using the Semidry Dot-Blot Method to Detect Metastatic Lymph Nodes in Breast Cancer: Distinguishing Macrometastases From Nonmacrometastases.
    Clin Breast Cancer 2017 Jul 15. Epub 2017 Jul 15.
    Division of Surgical Oncology, Nagasaki University Hospital, Nagasaki, Japan.
    Background: The semidry dot-blot method is a diagnostic procedure for detecting lymph node (LN) metastases using the presence of cytokeratin (CK) in lavage fluid from sectioned LNs. We evaluated 2 novel kits that use newly developed anti-CK-19 antibodies to diagnose LN metastases in breast cancer.

    Patients And Methods: We examined 159 LNs dissected that we sliced at 2-mm intervals and washed with phosphate-buffered saline. Read More

    Clinical Value of Real-Time Ultrasonography-MRI Fusion Imaging for Second-Look Examination in Preoperative Breast Cancer Patients: Additional Lesion Detection and Treatment Planning.
    Clin Breast Cancer 2017 Jul 14. Epub 2017 Jul 14.
    Medical Science Research Center, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
    Background: This study was conducted to evaluate the clinical effect of real-time magnetic resonance imaging (MRI)-navigated ultrasonography (US) for preoperative second-look examination in patients with breast cancer.

    Patients And Methods: Between October 2013 and February 2015, 232 patients with breast cancer underwent MRI for staging; second-look US was performed in 70 patients to evaluate additional lesions suspected to be disease detected using MRI. We retrospectively included 67 lesions in 55 patients. Read More

    Prospective Feasibility Trial of Sentinel Lymph Node Biopsy in the Setting of Inflammatory Breast Cancer.
    Clin Breast Cancer 2017 Jul 10. Epub 2017 Jul 10.
    Department of Breast Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas M.D. Anderson Cancer Center, Houston, TX.
    Background: Most inflammatory breast cancer (IBC) patients have axillary disease at presentation. Current standard is axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NACT). Advances in NACT have improved pathologic complete response (pCR) rates increasing interest in performing sentinel lymph node (SLN) biopsy (SLNB). Read More

    The Effect of Immediate Breast Reconstruction on Thoracic Spine Alignment After Unilateral Mastectomy.
    Clin Breast Cancer 2017 Jun 29. Epub 2017 Jun 29.
    Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Background: Long-term posture change after unilateral mastectomy in breast cancer patients can affect spinal alignment during the postoperative period. We evaluated the effect of immediate breast reconstruction on body posture after surgery by analyzing spinal alignment with radiographic studies.

    Materials And Methods: Preoperative and 2-year postoperative chest radiographs of 116 patients who received immediate breast reconstruction with unilateral mastectomy and 250 patients who underwent unilateral mastectomy without reconstruction were retrospectively reviewed. Read More

    Genetic Risk Factors Associated With Antiemetic Efficacy of Palonosetron, Aprepitant, and Dexamethasone in Japanese Breast Cancer Patients Treated With Anthracycline-based Chemotherapy.
    Clin Breast Cancer 2017 Jun 29. Epub 2017 Jun 29.
    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
    Introduction: Breast cancer patients often receive anthracycline-based chemotherapy, and chemotherapy-induced nausea and vomiting (CINV) remains one of the most uncomfortable and distressing adverse reactions. Poor control of CINV reduces the relative dose intensity of chemotherapy agents, which has been associated with poor clinical outcomes and shorter survival. The aim of the present study was to identify genetic risk factors associated with anthracycline-based CINV. Read More

    A Pilot Randomized Controlled Trial on the Effects of a Progressive Exercise Program on the Range of Motion and Upper Extremity Grip Strength in Young Adults With Breast Cancer.
    Clin Breast Cancer 2017 Jun 24. Epub 2017 Jun 24.
    Jewish General Hospital, Rehabilitation & Exercise Oncology Program, Hope & Cope, Montreal, QC, Canada; Division of Oncology, Canadian Physiotherapy Association, Ottawa, ON, Canada; Web-based Education and Professional Consultations, Ordre Professionelle de la Physiothérapie du Quebec, Anjou, QC, Canada. Electronic address:
    Background: The diagnosis of breast cancer in young women (aged 18-45 years) has been increasing. Women are commonly left coping with treatment-related disabilities of the upper limb that can persist for > 2 years postoperatively.

    Patients And Methods: A total of 59 young breast cancer patients (29 in the intervention group and 30 in the control group) participated in a pilot prospective randomized controlled trial to determine whether a 12-week postradiation exercise program would improve long-term arm mobility, pain, and handgrip strength. Read More

    Is Technetium-99m Sestamibi Imaging Able to Predict Pathologic Nonresponse to Neoadjuvant Chemotherapy in Breast Cancer? A Meta-analysis Evaluating Current Use and Shortcomings.
    Clin Breast Cancer 2017 Jun 29. Epub 2017 Jun 29.
    Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Nuclear Medicine, Alrijne Ziekenhuis, Leiderdorp, The Netherlands. Electronic address:
    Background: Interest in technetium-99m ((99m)Tc)-sestamibi imaging for neoadjuvant chemotherapy (NAC) response monitoring in locally advanced breast cancer (LABC) is increasing but remains matter of discussion. The present study conducted a meta-analysis of the diagnostic performance of (99m)Tc-sestamibi to predict pathologic nonresponse to NAC for primary LABC.

    Materials And Methods: A systematic data search was performed. Read More

    Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
    Clin Breast Cancer 2017 Jun 23. Epub 2017 Jun 23.
    Department of Radiation Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY. Electronic address:
    Background: Invasive pleomorphic lobular carcinoma (IPLC) has been associated with a worse prognosis compared with classic invasive lobular carcinoma (cILC); however, studies are small and conflicting. We seek to examine the prognosis of women with IPLC compared with cILC.

    Methods: A retrospective review of women with breast cancer at a single institution from 2003 to 2012 identified 193 women with invasive lobular carcinoma (ILC). Read More

    Borderline ER-Positive Primary Breast Cancer Gains No Significant Survival Benefit From Endocrine Therapy: A Systematic Review and Meta-Analysis.
    Clin Breast Cancer 2017 Jun 23. Epub 2017 Jun 23.
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China; Pathology Tissue Bank, Qilu Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. Electronic address:
    Endocrine responsiveness of primary breast cancers with borderline estrogen receptor expression (ER(+) [1%-9%]) remains unclear. We aimed at investigating differences in endocrine responsiveness, prognosis, and clinicopathological characteristics between the ER(+) (1%-9%) cohort and the ER(-) cohort or ER(+) (≥10%) cohort. Eligible literature published from inception to November 20, 2016 was retrieved from the PubMed database on the basis of Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

    A Rare Presentation of Primary Breast Carcinoma in the Vulva: A Case Report and Literature Review.
    Clin Breast Cancer 2017 Jun 23. Epub 2017 Jun 23.
    The Global Cancer Institute, Boston, MA; MGH-Avon Global Breast Cancer Program, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

    Risk Factors Affecting Breast Cancer-related Lymphedema: Serial Body Weight Change During Neoadjuvant Anthracycline Plus Cyclophosphamide Followed by Taxane.
    Clin Breast Cancer 2017 Jun 21. Epub 2017 Jun 21.
    Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. Electronic address:
    Introduction: The aim of our study was to analyze the risk of lymphedema (LE) according to the clinicopathologic factors and to investigate the serial change in body weight during neoadjuvant anthracycline plus cyclophosphamide followed by taxane and its correlation with the incidence of LE.

    Patients And Methods: We performed a retrospective 2-center study of 406 patients who had undergone neoadjuvant chemotherapy (NAC) followed by surgery from 2007 to 2014. The regimen included 4 cycles of anthracycline plus cyclophosphamide, followed by 4 cycles of taxane. Read More

    Locoregional Treatment of the Primary Tumor in Patients With De Novo Stage IV Breast Cancer: A Radiation Oncologist's Perspective.
    Clin Breast Cancer 2017 Jun 17. Epub 2017 Jun 17.
    Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
    Background: The aim of this study was to assess the outcomes of patients with de novo stage IV breast cancer after locoregional treatment (LRT) of primary site.

    Patients And Methods: We studied 245 patients diagnosed with de novo stage IV breast cancer. LRT of the primary tumor (+ systemic therapy) was performed in 82 (34%) patients (surgery, 27; surgery + radiotherapy (RT), 46; and RT, 9). Read More

    Coexistence of Ductal Carcinoma Within Mammary Phyllodes Tumor: A Review of 557 Cases From a 20-year Region-wide Database in Hong Kong and Southern China.
    Clin Breast Cancer 2017 Jun 17. Epub 2017 Jun 17.
    Department of Surgery, The University of Hong Kong, Hong Kong, China; Department of Surgery, Queen Mary Hospital, Hong Kong, China; Department of Surgery, The University of Hong Kong Shenzhen Hospital, Shenzhen, China. Electronic address:
    Introduction: Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature.

    Methods: A retrospective review of a prospectively maintained database was performed. Read More

    Cyanoacrylate Adhesive Reduces Seroma Production After Modified Radical Mastectomy or Quadrantectomy With Lymph Node Dissection-A Prospective Randomized Clinical Trial.
    Clin Breast Cancer 2017 Apr 13. Epub 2017 Apr 13.
    First Medical Propaedeutic Surgical Department, AHEPA University General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Introduction: The accumulation of fluid, a seroma, is a frequent complication after modified radical mastectomy or quadrantectomy with lymph node dissection. The aim of the present study was to examine whether a new adhesive material made of cyanoacrylate can effectively provide a sealing coat to tissues and thus reduce the incidence of seroma significantly.

    Patients And Methods: The present prospective, randomized case-control study included 128 women with a breast cancer diagnosis and scheduled for modified radical mastectomy or quadrantectomy with lymph node dissection in Thessaloniki, Greece. Read More

    How to Assess Sensory Recovery After Breast Reconstruction Surgery?
    Clin Breast Cancer 2017 Apr 29. Epub 2017 Apr 29.
    Department of Clinical Neurophysiology, Turku University Hospital, Turku, Finland.
    Background: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses.

    Patients And Methods: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction. Healthy contralateral breasts (36 patients) and 20 healthy volunteer women served as control participants. Read More

    Impact of Interaction Between PPAR Alpha and PPAR Gamma on Breast Cancer Risk in the Chinese Han Population.
    Clin Breast Cancer 2017 Aug 19;17(5):336-340. Epub 2016 Oct 19.
    Department of Thoracic Surgery, Tongchuan District, Dazhou, Sichuan Province, China.
    Background: Several studies have been conducted to investigate the association of the peroxisome proliferator-activated receptor (PPAR) alpha (PPAR A) and PPAR gamma (PPAR G) polymorphism and breast cancer (BC) risk, but the results were inconsistent, and, until now, no study focused on the impact of gene-gene interactions between PPAR A and PPAR G on BC risk; thus, the aim of this study was to investigate the impact of interaction between PPAR A and PPAR G on BC risk in the Chinese Han population.

    Methods: A total of 862 participants with a mean age of 63.0 ± 15. Read More

    Patient Case Lessons: Endocrine Management of Advanced Breast Cancer.
    Clin Breast Cancer 2017 Jun 7. Epub 2017 Jun 7.
    US Oncology Research Network, Arlington, VA.
    Advances in treatment for women with advanced breast cancer (ABC) have led to improvements in survival. Although the condition remains incurable, treatment goals focus on stabilizing disease, prolonging life, and maintaining patient quality of life. Hormone receptor-positive (HR(+)) subtypes constitute the majority of breast cancers, and an increasing number of effective endocrine therapies are available. Read More

    Single-Agent Oral Vinorelbine as First-Line Chemotherapy for Endocrine-Pretreated Breast Cancer With Bone Metastases and No Visceral Involvement: NORBREAST-228 Phase II Study.
    Clin Breast Cancer 2017 Jun 27. Epub 2017 Jun 27.
    Institut de Recherche Pierre Fabre, Boulogne-Billancourt Cédex, France.
    Purpose: Single-agent oral chemotherapy is widely used in patients with bone metastases without visceral involvement, especially in hormone receptor-positive metastatic breast cancer (mBC). However, this option has been poorly evaluated in clinical trials.

    Methods: Eligible patients had mBC with predominantly bone but not visceral metastases, were receiving bisphosphonate therapy, and had previously received endocrine therapy (any setting) but not chemotherapy for mBC. Read More

    Vaginal Atrophy in Breast Cancer Survivors: Attitude and Approaches Among Oncologists.
    Clin Breast Cancer 2017 May 19. Epub 2017 May 19.
    Immunology and Oncology Therapeutic Area, Medical Affairs Department, Italfarmaco SpA, Milan, Italy.
    Background: Vulvovaginal atrophy (VVA) is a relevant problem for breast cancer survivors (BCSs), in particular for those who receive aromatase inhibitors (AIs). We conducted a survey, to assess the attitude of oncologists toward the diagnosis and treatment of VVA in BCSs.

    Materials And Methods: In 2015, 120 computer-assisted Web interviews were performed among breast oncologists. Read More

    Fine Needle Aspiration Combined With Matrix-assisted Laser Desorption Ionization Time-of-Flight/Mass Spectrometry to Characterize Lipid Biomarkers for Diagnosing Accuracy of Breast Cancer.
    Clin Breast Cancer 2017 Aug 25;17(5):373-381.e1. Epub 2017 May 25.
    Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
    Background: Fine needle aspiration (FNA) cytology has been widely used for pathologic assessment of breast lesions. However, the examination suffers a risk of false-negative results owing to insufficient sample volumes, inaccurate sampling positions, nondefinitive cytologic features, or suboptimal cell preservation. One approach to improve its accuracy is using modern mass spectrometry to detect disease biomarkers, of which the tissue samples are collected through FNA. Read More

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