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    1412 results match your criteria Clinical breast cancer[Journal]

    1 OF 29

    Feasibility Study of Weekly Nanoparticle Albumin-Bound Paclitaxel (150 mg/m) Followed by Fluorouracil, Epirubicin, and Cyclophosphamide Therapy as Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer.
    Clin Breast Cancer 2018 Jan 11. Epub 2018 Jan 11.
    Division of Breast and Endocrine Surgery, Department of Surgery, St Marianna University School of Medicine, Miyamae, Japan.
    Background: Although several studies have shown efficacy of nanoparticle albumin-bound (nab) paclitaxel use as a neoadjuvant treatment in breast cancer, dosage and schedules were varied or used in combination and the data are still limited for weekly regimens. We evaluated the feasibility of weekly nab-paclitaxel followed by FEC (5-FU [fluorouracil], epirubicin, and cyclophosphamide) treatment feasibility as neoadjuvant chemotherapy for breast cancer.

    Patients And Methods: Thirty-three patients with no previous chemotherapy were enrolled to receive nab-paclitaxel 150 mg/mthe first 3 of 4 weeks (3q4w) followed by FEC as neoadjuvant treatment. Read More

    Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample.
    Clin Breast Cancer 2018 Jan 31. Epub 2018 Jan 31.
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
    Introduction: The murine double minute 4 (MDM4) protein is a negative regulator of p53, and its upregulation has been observed in many tumor types. Previous literature suggested that genetic variations in the MDM4 gene are associated with risk of different cancers. The objective of the present study was to examine the effect of 3 common genetic variants of MDM4, rs4245739 A>C, rs11801299 G>A, and rs1380576 C>G, on the risk of breast cancer (BC) in a southeast Iranian population sample. Read More

    Review of Novel Sentinel Lymph Node Biopsy Techniques in Breast Cancer Patients Treated With Neoadjuvant Chemotherapy.
    Clin Breast Cancer 2018 Jan 31. Epub 2018 Jan 31.
    Bahcelievler Medicana Hospital, General Surgery Department, Istanbul, Turkey.
    Breast cancer patients who present with nodal metastasis receive neoadjuvant chemotherapy (NAC) with increasing frequency and can have complete pathologic response after treatment. In this clinical scenario, sentinel node mapping and biopsy are gaining acceptance instead of axillary dissection to avoid morbidity. Biopsy proven positive lymph nodes must be reliably excised and examined after NAC to further decrease the false negativity rate of sentinel lymph node (SLN) surgery. Read More

    Initiation of Adjuvant Endocrine Therapy in Black and White Women With Breast Cancer.
    Clin Breast Cancer 2017 Dec 12. Epub 2017 Dec 12.
    Department of Mathematics and Statistics, Georgetown University, Washington, DC.
    Background: Adjuvant endocrine therapy reduces risk of recurrence and mortality in women with hormone receptor-positive breast cancer, yet many women never initiate it. We examined the influence of race, sociocultural factors, and process-of-care factors on initiation of adjuvant endocrine therapy in a racially diverse sample.

    Patients And Methods: Eligible women were originally recruited for the Narrowing the Gaps in Adjuvant Therapy Study (2006-2011). Read More

    Expression Analysis of miR-29b in Malignant and Benign Breast Tumors: A Promising Prognostic Biomarker for Invasive Ductal Carcinoma With a Possible Histotype-Related Expression Status.
    Clin Breast Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:
    Background: Aberrations in microRNA levels seem to provide valuable information regarding breast cancer prognosis and therapy. In this study, we sought to analyze miR-29b expression in breast tumors and thus explore its clinical value.

    Materials And Methods: One hundred twenty-one malignant and 56 benign breast tissue specimens were collected and subjected to extraction of total RNA, which was polyadenylated and reverse transcribed to cDNA. Read More

    Impact of BRCA Mutation Status on Survival of Women With Triple-negative Breast Cancer.
    Clin Breast Cancer 2017 Dec 30. Epub 2017 Dec 30.
    Nancy and James Grosfeld Cancer Genetics Center, Beaumont Cancer Institute, Beaumont Health, Royal Oak, MI; Oakland University William Beaumont School of Medicine, Rochester, MI.
    Introduction: The effect of germline BRCA mutations on the outcomes of patients with triple-negative breast cancer (TNBC) is not well understood.

    Materials And Methods: The present retrospective study included women with newly diagnosed TNBC from January 1, 2004 to December 30, 2013. The demographic and tumor characteristics, genetic testing results, and outcomes were collected by a review of the patients' medical records. Read More

    Techniques Used to Localize Occult Breast Lesions: An Update.
    Clin Breast Cancer 2018 Jan 5. Epub 2018 Jan 5.
    Department of Breast Surgery, New Cross Hospital, Wolverhampton, United Kingdom. Electronic address:
    With breast cancer screening programs becoming more available worldwide and covering larger age ranges, the prevalence of impalpable breast pathology is increasing. Whilst there is a 'tried and tested' technique for localizing occult lesions, the market for alternative methods is increasing and is estimated to pass $1 billion by 2024. In this article, we review the techniques currently available for localization of occult breast lesions and discuss the pros and cons of each. Read More

    Review of Factors Influencing Women's Choice of Mastectomy Versus Breast Conserving Therapy in Early Stage Breast Cancer: A Systematic Review.
    Clin Breast Cancer 2018 Jan 3. Epub 2018 Jan 3.
    Community Health and Epidemiology, University of Saskatchewan, Saskatoon, SK, Canada.
    We have performed a narrative synthesis. A literature search was conducted between January 2000 and June 2014 in 7 databases. The initial search identified 2717 articles; 319 underwent abstract screening, 67 underwent full-text screening, and 25 final articles were included. Read More

    Detection of Human Cytomegalovirus in Malignant and Benign Breast Tumors in Egyptian Women.
    Clin Breast Cancer 2017 Nov 7. Epub 2017 Nov 7.
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
    Introduction: Previous studies have reported a role for human cytomegalovirus (HCMV) in breast carcinogenesis. We sought to assess the role of HCMV infection in the development and/or progression of breast cancer (BC) among Egyptian patients.

    Patients And Methods: The study included 61 patients with BC cases. Read More

    Effect of Aromatase Inhibitor Therapy on Sleep and Activity Patterns in Early-stage Breast Cancer.
    Clin Breast Cancer 2017 Dec 27. Epub 2017 Dec 27.
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI. Electronic address:
    Introduction: Adherence to aromatase inhibitor (AI) therapy is poor, often because of treatment-emergent side effects, including musculoskeletal symptoms, fatigue, and insomnia. In the present analysis, we examined the sleep patterns and daytime function both objectively using actigraphy and subjectively using validated questionnaires in women initiating AI therapy.

    Patients And Methods: Postmenopausal women with stage 0-III hormone receptor-positive breast cancer who were initiating AI therapy were eligible. Read More

    Characteristics and Prognostic Factors for Patients With HER2-overexpressing Breast Cancer and Brain Metastases in the Era of HER2-targeted Therapy: An Argument for Earlier Detection.
    Clin Breast Cancer 2017 Dec 21. Epub 2017 Dec 21.
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    Background: Although brain metastases (BM) are associated with poor prognosis, patients with human epidermal growth factor receptor 2 (HER2) overexpressing (HER2) breast cancer (BC) with BM who are treated with anti-HER2 therapy have a relatively longer survival after BM diagnosis compared with other subtypes and HER2patients previously untreated with anti-HER2 therapy. It is unclear if previously reported prognostic factors are applicable to patients with HER2BC in the era of HER2-targeted therapy.

    Patients And Methods: We evaluated 100 consecutive patients with HER2BC with BM who underwent radiation therapy as primary BM treatment from January 2001 to December 2011 at Memorial Sloan Kettering Cancer Center by retrospective review. Read More


    Ki-67 Expression as a Factor Predicting Recurrence of Ductal Carcinoma In Situ of the Breast: A Systematic Review and Meta-Analysis.
    Clin Breast Cancer 2017 Dec 16. Epub 2017 Dec 16.
    Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National University of Athens, Athens, Greece. Electronic address:
    Background: Ki-67 is a marker of proliferating cells; in this meta-analysis we aimed to examine whether Ki-67 expression can predict recurrence rates of breast ductal carcinoma in situ (DCIS).

    Materials And Methods: This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible articles were sought in MEDLINE up to April 30, 2017. Read More

    Clinical Impact of 21-Gene Recurrence Score Test Within the Veterans Health Administration: Utilization and Receipt of Guideline-Concordant Care.
    Clin Breast Cancer 2017 Nov 29. Epub 2017 Nov 29.
    Durham VA Medical Center, Durham, NC; Duke University, Durham, NC.
    Introduction: Ensuring guideline-concordant cancer care is a Department of Veterans Affairs (VA) priority, especially as the number of breast cancer patients at VA medical centers (VAMCs) grows. We assessed the utilization and clinical impact of the 21-gene Recurrence Score test, which predicts 10-year risk of breast cancer recurrence and the likelihood of chemotherapy benefit, on veterans newly diagnosed with breast cancer.

    Patients And Methods: We conducted a retrospective cohort study using 2011-2012 VA Central Cancer Registry, chart review, and laboratory test data. Read More

    Breast Osteoblast-like Cells: A Reliable Early Marker for Bone Metastases From Breast Cancer.
    Clin Breast Cancer 2017 Dec 5. Epub 2017 Dec 5.
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; TMALab s.r.l., Spin-off of University of Rome Tor Vergata, Rome, Italy. Electronic address:
    Background: The development of bone metastasis from breast cancer results from a functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of this study was therefore to test the hypothesis that the appearance of breast osteoblast-like cells (BOLCs) in primary mammary lesions is a precursor (and hence an early predictor) of the formation of breast cancer metastases to bone.

    Patients And Methods: In this study, we collected 64 breast infiltrating carcinomas, 50 breast benignant lesions, and 10 biopsies of bone metastasis selected from patients with infiltrated carcinoma. Read More

    Evaluation of Prognosis in Hormone Receptor-Positive/HER2-Negative and Lymph Node-Negative Breast Cancer With Low Oncotype DX Recurrence Score.
    Clin Breast Cancer 2017 Dec 14. Epub 2017 Dec 14.
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA. Electronic address:
    Introduction: Hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancers without lymph node metastasis have good prognosis. We compared the prognosis of hormone receptor-positive, HER2-negative, lymph node-negative cancers with Oncotype DX score ranges of 1 to 10 (1-10 group) and 11 to < 18 (11-18 group).

    Patients And Methods: A total of 107 cases in the 1-10 group and 225 cases in the 11-18 group were reviewed. Read More

    Role of Age, Tumor Grade, and Radiation Therapy on Immediate Postmastectomy Breast Reconstruction.
    Clin Breast Cancer 2017 Dec 7. Epub 2017 Dec 7.
    Department of Surgery, University of North Carolina, Chapel Hill, NC; Division of Surgical Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA.
    Background: Despite the psychological benefits and oncologic safety of postmastectomy breast reconstruction, most breast cancer patients do not undergo reconstruction. To better understand the patterns of breast reconstruction usage, it is important to identify the clinicopathologic factors associated with immediate breast reconstruction (IBR), and whether modification of the reconstruction incidence when stratified by patient- or cancer-related factors exists in the breast cancer population. The primary objectives were to determine whether the incidence of immediate postmastectomy breast reconstruction varies across age, and whether the tumor grade or radiation therapy modify the effect of age on the incidence of immediate breast reconstruction. Read More

    Abnormal Findings Detected by Multi-modality Breast Imaging and Biopsy Results in a High-risk Clinic.
    Clin Breast Cancer 2017 Dec 11. Epub 2017 Dec 11.
    Oncogenetics Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Meirav High-risk Clinic, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Background: High-risk BRCA mutation carriers are offered a surveillance scheme aimed at early detection of breast cancer. Although the efficacy of this scheme in breast cancer detection is well-established, the rate of breast cancer diagnosis of radiologically suspicious lesions and the effect of this screening scheme on breast cancer grade and stage are less well-defined.

    Patients And Methods: Female BRCA1 and BRCA2 mutation carriers who were cancer-free at the beginning of follow-up at the Meirav High-risk Clinic, Sheba Medical Center, were eligible. Read More

    Evaluation of miRNA-21 and miRNA Let-7 as Prognostic Markers in Patients With Breast Cancer.
    Clin Breast Cancer 2017 Dec 7. Epub 2017 Dec 7.
    Clinical and Chemical Pathology Department, Medical Division, National Research Centre, Cairo, Egypt.
    Background: Breast cancer remains one of the top threats to women's health. The current lack of tumor markers with desirable sensitivity and specificity is a major obstacle toward the future management of breast cancer. Many studies are directed to reveal the diagnostic and prognostic potentials of circulating miRNAs in breast cancer. Read More

    Association Between Postoperative Complications After Immediate Alloplastic Breast Reconstruction and Oncologic Outcome.
    Clin Breast Cancer 2017 Dec 7. Epub 2017 Dec 7.
    Department of Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Introduction: Mastectomy with immediate reconstruction is associated with increased complications when compared with mastectomy without reconstruction. Postoperative complications have been associated with worse oncologic outcome in other cancers. We examined the association between postoperative complications after immediate reconstruction and oncologic outcome. Read More

    Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.
    Clin Breast Cancer 2017 Dec 11. Epub 2017 Dec 11.
    Department of Medical Oncology, Institut Régional Du Cancer de Montpellier ICM, Montpellier, France. Electronic address:
    Introduction: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D levels during neoadjuvant chemotherapy (NAC) on the rates of achieving pathologic complete response (pCR) after breast cancer NAC. Read More

    Adherence to Adjuvant Endocrine Therapy in Women With Breast Cancer: A Prospective Observational Study in Japanese Women.
    Clin Breast Cancer 2017 Dec 12. Epub 2017 Dec 12.
    Department of Surgery, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
    Introduction: Nonadherence to adjuvant endocrine therapy has been poorly studied in Asian patients with breast cancer. We therefore assessed adherence to endocrine therapy among women with breast cancer in Japan.

    Patients And Methods: We conducted a prospective observational study among Japanese women with hormone receptor-positive breast cancer. Read More

    Prevention of Tamoxifen-related Nonalcoholic Fatty Liver Disease in Breast Cancer Patients.
    Clin Breast Cancer 2017 Nov 23. Epub 2017 Nov 23.
    School of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: Tamoxifen is commonly used to prevent breast cancer recurrence. Studies have confirmed the association between tamoxifen and nonalcoholic fatty liver disease (NAFLD), with the results indicating the need for aggressive management of this side effect. We assessed the potential risk factors for and identified the possible protective factors of tamoxifen-related fatty liver. Read More

    A European, Observational Study of Endocrine Therapy Administration in Patients With an Initial Diagnosis of Hormone Receptor-Positive Advanced Breast Cancer.
    Clin Breast Cancer 2017 Nov 29. Epub 2017 Nov 29.
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
    Background: Despite guideline recommendations, reports suggest that a proportion of patients with hormone receptor (HR)-positive locally advanced or metastatic breast cancer (LA/MBC) might not receive endocrine therapy. The aims of this study were to estimate the proportion of postmenopausal patients with an initial (primary) diagnosis of HR-positive LA/MBC in Europe, and to assess the administration of endocrine treatment in these patients. MATERIALS AND METHODS: Fourteen national and regional cancer registries across Europe were invited to participate in this observational study. Read More

    Association of Tobacco Use, Alcohol Consumption and HER2 Polymorphisms With Response to Trastuzumab in HER2-Positive Breast Cancer Patients.
    Clin Breast Cancer 2017 Nov 23. Epub 2017 Nov 23.
    Centre de Recherche sur le cancer de l'Université Laval, Québec, Canada; Axe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada; Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, Canada; Faculté de Médecine, Université Laval, Québec, Canada. Electronic address:
    Purpose: Although the administration of trastuzumab has improved the survival of human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, resistance remains a major clinical obstacle. We retrospectively evaluated the association of HER2 polymorphisms, tobacco use and alcohol consumption with disease-free survival (DFS) in HER2-positive breast cancer patients.

    Patients And Methods: Clinicopathologic and survival data (median follow-up, 7. Read More

    Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer.
    Clin Breast Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan.
    Background: Wild type p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase magnesium dependent 1 delta (PPM1D), inhibits p53. PPM1D amplification has been reported in breast cancer. Breast cancer can sometimes develop without a tumor protein 53 (TP53) mutation. Read More

    Preferred and Perceived Participation of Younger and Older Patients in Decision Making About Treatment for Early Breast Cancer: A Prospective Study.
    Clin Breast Cancer 2017 Nov 28. Epub 2017 Nov 28.
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
    Background: Older patients are believed to prefer a more passive role in treatment decision making, but studies reporting this relation were conducted over a decade ago or were retrospective. We prospectively compared younger (40-64 years) versus older (≥ 65 years) breast cancer patients' preferences for decision-making roles and their perceived actual roles.

    Patients And Methods: A prospective multicenter study was conducted in Leiden, The Hague, and Tilburg over a 2-year period. Read More

    One-Step Prepectoral Breast Reconstruction With Dermal Matrix-Covered Implant Compared to Submuscular Implantation: Functional and Cost Evaluation.
    Clin Breast Cancer 2017 Dec 2. Epub 2017 Dec 2.
    Breast Surgical Unit, University Hospital of Parma, Parma, Italy.
    Background: The breast reconstructive subpectoral technique commonly leads to functional consequences. Recently, a new conservative prepectoral breast reconstruction (PPBR) technique was proposed and its surgical safety and aesthetic effectiveness proved. The aim of this prospective nonrandomized study was to compare the functional and economical outcomes of the PPBR procedure versus the subpectoral one. Read More

    Bilateral Breast Cancer After Multimodality Treatment: A Report of Clinical Outcomes in an Asian Population.
    Clin Breast Cancer 2017 Nov 9. Epub 2017 Nov 9.
    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
    Background: Bilateral breast cancer (BBC) is an uncommon presentation. The characteristics and outcomes of synchronous and metachronous BBC were compared within an Indian cohort.

    Patients And Methods: This was a retrospective audit of 193 BBC patients treated at a tertiary hospital in India over a period of 10 years from January 2004 to December 2014. Read More

    Evaluation of Discordance in Primary Tumor and Lymph Node Response After Neoadjuvant Therapy in Breast Cancer.
    Clin Breast Cancer 2017 Nov 23. Epub 2017 Nov 23.
    Breast Research Centre, Cork University Hospital, Cork, Ireland.
    Background: Neoadjuvant therapy (NAT) offers a unique opportunity to assess tumor response to systemic agents. However, a discrepancy may exist between the response of the primary tumor and involved nodes. We report on the frequency of response discordance after NAT in breast cancer. Read More

    Determinants of Weight Gain During Adjuvant Endocrine Therapy and Association of Such Weight Gain With Recurrence in Long-term Breast Cancer Survivors.
    Clin Breast Cancer 2018 Feb 9;18(1):e7-e13. Epub 2017 Nov 9.
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:
    Background: Weight gain is a negative prognostic factor in breast cancer (BC) patients. The risk factors for weight gain during adjuvant endocrine therapy (ET) and the extent to which such weight gain is associated with disease recurrence remain unclear.

    Patients And Methods: We retrospectively identified a cohort of women with a diagnosis of stage I-III, hormone receptor-positive, human epidermal growth factor receptor 2-negative BC from January 1997 to August 2008, who had received initial treatment at the MD Anderson Cancer Center, had completed 5 years of ET, and had remained free of locoregional or distant relapse or contralateral BC for ≥ 5 years after diagnosis. Read More

    Income Inequality and Mortality Owing to Breast Cancer: Evidence From Brazil.
    Clin Breast Cancer 2017 Nov 9. Epub 2017 Nov 9.
    Laboratório de Epidemiologia e Análise de Dados, Faculdade de Medicina do ABC, Santo André, Brasil.
    Background: The relationship between breast cancer and inequality income is unclear. This study analyzed the correlation between income inequality and mortality standardized by age and proportional mortality owing to breast cancer among Brazilian women.

    Patients And Methods: This is an ecological study using data of the federative units and Federal District of Brazil in 2010. Read More


    Role of the Functional Polymorphism of Survivin Gene (-31G/C) and Risk of Breast Cancer in a North Indian Population.
    Clin Breast Cancer 2017 Nov 23. Epub 2017 Nov 23.
    Department of Virology and Immunology, Amity University Uttar Pradesh, Noida, India. Electronic address:
    Introduction: Survivin is an apoptosis inhibitor and plays a primary role in cancer development and progression. One of the most common polymorphism of the survivin promoter -31G/C (rs9904341) influences its expression and is associated with the risk of cancer development. This study was conducted to explore survivin promoter gene -31G/C (rs9904341) polymorphism and the risk of breast cancer. Read More

    Isolated Contralateral Axillary Lymph Node Involvement in Breast Cancer Represents a Locally Advanced Disease Not Distant Metastases.
    Clin Breast Cancer 2017 Nov 10. Epub 2017 Nov 10.
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:
    Background: Breast cancer metastases to an ipsilateral supraclavicular lymph node is assigned a N3 status in the TNM system and thus classified as stage III disease in the American Joint Commission on Cancer staging manual. Breast cancer metastatic to contralateral axillary lymph node (CAM) without metastases to any other distant organ is currently assigned M1 status (stage IV) instead of N3 (stage III).

    Patients And Methods: We retrospectively reviewed the medical records of breast cancer patients diagnosed with CAM for their clinical presentation, pathologic diagnoses, treatment, and follow-up data. Read More

    Physical Activity and Weight Loss Reduce the Risk of Breast Cancer: A Meta-analysis of 139 Prospective and Retrospective Studies.
    Clin Breast Cancer 2017 Oct 17. Epub 2017 Oct 17.
    The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Sydney Medical School Nepean, Penrith, New South Wales, Australia. Electronic address:
    Background: Physical activity and weight loss have been shown to reduce breast cancer incidence in numerous observational studies. The aim of this meta-analysis was to assess the effect of both physical activity and weight loss on breast cancer incidence. Specifically, we aimed to complete subgroup analyses by the intensity of physical activity and menopausal status at breast cancer diagnosis to further elucidate the relationship between physical activity, weight loss, and breast cancer incidence. Read More

    Tumor-Suppressing Effect of Silencing of Annexin A3 Expression in Breast Cancer.
    Clin Breast Cancer 2017 Nov 21. Epub 2017 Nov 21.
    Department of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.
    Introduction: Annexin A3 (ANXA3) participates in various tumor-associated biological processes, including tumor initiation, progression, and metastasis. The present study was designed to investigate the expression and function of ANXA3 in breast cancer cells.

    Materials And Methods: Annexin A3 protein expression in breast cancer cell lines was evaluated using Western blot analysis. Read More

    Treatment Patterns and Outcomes of Patients With Metastatic ER/HER-2Breast Cancer: A Multicountry Retrospective Medical Record Review.
    Clin Breast Cancer 2017 Oct 14. Epub 2017 Oct 14.
    RTI Health Solutions, Waltham, MA.
    Purpose: To describe treatment patterns and clinical outcomes among postmenopausal women with metastatic ER/HER-2breast cancer treated with ≥ 2 lines of endocrine therapy or chemotherapy in the metastatic setting.

    Patients And Methods: Retrospective medical record review was conducted in Canada, the United Kingdom, Belgium, the Netherlands, Germany, Spain, and France. Baseline characteristics were assessed at the date of metastatic diagnosis. Read More

    Diagnostic Performance of Mammographic Texture Analysis in the Differential Diagnosis of Benign and Malignant Breast Tumors.
    Clin Breast Cancer 2017 Nov 9. Epub 2017 Nov 9.
    Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:
    Background: The purpose of this study was to investigate the diagnostic performance of mammographic texture analysis in the differential diagnosis of benign and malignant breast tumors.

    Patients And Methods: Digital mammography images were obtained from the Picture Archiving and Communication System at our institute. Texture features of mammographic images were calculated. Read More

    Evaluation of Immune Reaction and PD-L1 Expression Using Multiplex Immunohistochemistry in HER2-Positive Breast Cancer: The Association With Response to Anti-HER2 Neoadjuvant Therapy.
    Clin Breast Cancer 2017 Nov 9. Epub 2017 Nov 9.
    Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, OH. Electronic address:
    Background: Immune reaction with tumor-infiltrating lymphocytes (TILs) has been extensively investigated in breast cancer. Programmed cell death 1 and its ligand (PD-L1) are key physiologic suppressors of cytotoxic immune reaction. However, the combination of TILs with PD-L1 expression has not been well studied in breast cancer. Read More

    Evaluation of Multifocality and Multicentricity With Breast Magnetic Resonance Imaging in Each Breast Cancer Subtype.
    Clin Breast Cancer 2017 Oct 28. Epub 2017 Oct 28.
    Ospedali Riuniti Azienda Ospedaliero Universitaria Ospedali Riuniti - Dipartimento Radiologia Clinica, Ancona, Italy.
    Introduction: The purpose of this study was to evaluate whether diagnostic performance of breast magnetic resonance imaging (MRI) for detection of multifocality and multicentricity (MFMC) of breast cancer (BC) can be influenced by different histotypes or immunophenotypes in newly diagnosed patients with breast cancer.

    Materials And Methods: In this institutional review board-approved retrospective study, 289 patients who underwent both preoperative breast MRI and radical or modified mastectomy in our institution because of primary BCs were selected. Patients were stratified based on the pathologic report in 2 main histotypes and 5 immunophenotypes. Read More

    Successful Repatriation of Breast Cancer Surveillance for High-Risk Women to the UK National Health Service Breast Screening Programme.
    Clin Breast Cancer 2017 Oct 28. Epub 2017 Oct 28.
    Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom.
    Background: Since April 2013, the UK's National Health Service Breast Screening Programme (NHSBSP) centers have been obliged to provide services for women at the highest risk of breast cancer, including those carrying highly penetrant single gene mutations (BRCA1, BRCA2, TP53). Since then, such individuals previously undergoing surveillance in the Royal Marsden Hospital were referred to their local NHSBSP centers. We aimed to assess patient experience of surveillance provided by local NHSBSP services at 1 and 3 years after repatriation. Read More

    The Effect of Total Size of Lesions in Multifocal/Multicentric Breast Cancer on Survival.
    Clin Breast Cancer 2017 Nov 9. Epub 2017 Nov 9.
    Mustafa Kadri Altundag (MKA) Breast Cancer Clinic, Ankara, Turkey. Electronic address:
    Background: In this study, we aimed to assess the prognostic performance of determining the T stage according to the total size of lesions compared with the size of the largest lesion in the breast in patients with multifocal/multicentric (MF/MC) breast cancer.

    Patients And Methods: The charts of the patients with MF/MC breast cancer who were diagnosed between 2003 and 2014 were reviewed. The T stage of MF/MC tumors was determined according to the largest lesion size (T) as well as the sum of the longest diameters of the lesions (T) in the breast. Read More

    Phase I/II Trial of Combined Pegylated Liposomal Doxorubicin and Cyclophosphamide in Metastatic Breast Cancer.
    Clin Breast Cancer 2018 Feb 9;18(1):e143-e149. Epub 2017 Oct 9.
    Department of Medicine, University of Washington, Seattle, WA; Seattle Cancer Care Alliance, Seattle, WA. Electronic address:
    Introduction: Doxorubicin in combination with cyclophosphamide is active in breast cancer; however, its use in metastatic cancer is limited owing to cardiotoxicity. Pegylated liposomal doxorubicin (PLD) was formulated to decrease the toxicity of conventional doxorubicin. We evaluated the safety and efficacy of PLD with metronomic oral cyclophosphamide. Read More

    Negative Valence Life Events Promote Breast Cancer Development.
    Clin Breast Cancer 2017 Nov 1. Epub 2017 Nov 1.
    Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA. Electronic address:
    Background: The influence of stress on breast cancer risk remains unknown. The goal of the present study was to determine the effect of stress in the form of salient positive and negative valence life events (LEs) on primary invasive breast cancer risk. We hypothesized that salient negative LEs would increase breast cancer risk and salient positive LEs would attenuate this increased risk. Read More

    Air Travel and Postoperative Lymphedema-A Systematic Review.
    Clin Breast Cancer 2018 Feb 19;18(1):e151-e155. Epub 2017 Oct 19.
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region. Electronic address:
    Lymphedema is not uncommon after axillary dissection for breast cancer. Improved survival of patients with breast cancer from advances in adjuvant therapy has resulted in increased awareness of the quality of life for long-term survivors. Air travel has been postulated as 1 of the risk factors of lymphedema exacerbation. Read More

    A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer.
    Clin Breast Cancer 2017 Oct 28. Epub 2017 Oct 28.
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.
    Background: Buparlisib is an oral pan-class I phosphotidyinositol-3-kinase (PI3K) inhibitor. The present phase I study evaluated the safety, pharmacokinetics, and efficacy of buparlisib with capecitabine in patients with metastatic breast cancer.

    Patients And Methods: Patients received buparlisib once daily (range, 50 to 100 mg) for 3 weeks with capecitabine twice daily (range, 1000 to 1250 mg/m) for 2 weeks with a 1-week break. Read More

    Weekly Paclitaxel and Carboplatin Plus Bevacizumab as First-Line Treatment of Metastatic Triple-Negative Breast Cancer. A Multicenter Phase II Trial by the Hellenic Oncology Research Group.
    Clin Breast Cancer 2018 Feb 24;18(1):88-94. Epub 2017 Oct 24.
    Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece. Electronic address:
    Background: Triple-negative breast cancer (TNBC) lacks a standard targeted therapeutic strategy and is treated with conventional cytotoxic agents. Because of the sensitivity of TNBC to platinum compounds and the synergistic effect of bevacizumab with paclitaxel we investigated the efficacy and toxicity of weekly paclitaxel and carboplatin in combination with bevacizumab as first-line treatment in metastatic TNBC.

    Patients And Methods: This phase II study followed the Simon's 2-stage optimal design. Read More

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