4,362,410 results match your criteria Clinical biomechanics Bristol Avon[Journal]


[Reconstruction of neglected Achilles tendon rupture: flexor hallucis longus transfer versus gastrocnemius turn-down flaps].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):542-546

Institute of Sports Medicine, Peking University Third Hospital, Beijing 100191, China.

To compare the outcome of either flexor hallucis longus transfer or turn-down of proximal Achilles tendon tissue repair in treating chronic Achilles tendon rupture. The clinical data of 21 patients who underwent repair of Myerson type Ⅲ chronic Achilles tendon rupture at Peking University Sports Medicine Research Institute from May 2012 to March 2015 were retrospectively analyzed. Among them, 11 cases were treated with flexor hallucis longus (FHL) transfer, and 10 cases were treated with gastrocnemius turn-down flaps repair. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.013DOI Listing
February 2019

[Different care models and symptom progression of Alzheimer's disease in China].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):532-536

Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To compare the differences of cognitive function, daily living ability and neuropsychiatric symptoms in patients with sporadic type of Alzheimer's disease (AD) under different care modes, and find the most favorable care mode for delaying the progress of disease. One hundred and twenty cases of AD patients were divided into three groups: Spouse Care Group, Adult Child Care Group and Nursing Home Group. Medical history collection and scale evaluation were carried out by trained specialists on 3 groups of patients and caregivers. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.011DOI Listing
February 2019

[Application of stretched exponential diffusion-weighted imaging model in quantitative diagnosis of nonalcoholic fatty liver disease: in a rabbit model].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):500-504

Department of Radiology, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, China.

To evaluate the feasibility of diffusion parameters obtained from mono-exponential and stretched exponential diffusion-weighted imaging models in staging of nonalcoholic fatty liver disease and compare the diagnosis ability of nonalcoholic steatohepatitis. Thirty-two 12 -week-old male New Zealand rabbits, about 2.5 kg of each, were randomly divided into five groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.005DOI Listing
February 2019

[Magnetic resonance imaging and diffusion weighted imaging features of focal peliosis hepatis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):496-499

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the MRI and diffusion weighted imaging (DWI) features of focal peliosis hepatis. The clinical data and MRI of 19 cases with focal peliosis hepatis confirmed by pathology from January 2012 to March 2018 in Zhongshan Hospital of Fudan University were retrospectively analyzed. The number, location, size, shape, signal intensity of plain scan of lesions, enhancement pattern of lesions, vessels within lesions, and perfusion disorders of hepatic parenchyma were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.004DOI Listing
February 2019

[Computer-aided assessment of liver fibrosis progression in patients with chronic hepatitis B: an exploratory research].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):491-495

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Fudan University, Shanghai 200032, China.

To establish automatic liver fibrosis classification models by using traditional machine learning and deep learning methods and preliminaryly evaluate the efficiency. Gray scale ultrasound images and corresponding elastic images of 354 patients, 247 males and 107 females, mean age (54±12) years undergoing partial hepatectomy in Zhongshan Hospital of Fudan University from November 2014 to January 2016 were enrolled in this study. By using traditional machine learning and deep learning methods, an automatic classification model of liver fibrosis stages (S0 to S4) were established through feature extraction and classification of ultrasound image data sets and the accuracy in different classification categories of each model were calculated, by using liver biopsy as the reference standard. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.003DOI Listing
February 2019

[Changes of intestinal mucosal barrier function and effects of early enteral nutrition in patients with severe organophosphorus poisoning].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):442-446

Intensive Care Unit, Bozhou People's Hospital Affiliated to Anhui University of Science and Technology, Bozhou 236800, China.

To observe the changes of intestinal barrier function in patients with acute severe organophosphorus pesticide poisoning (ASOPP) and the effect of early enteral nutrition on them. A single-center, single-sample, prospective, randomized controlled clinical trial was conducted. A total of 50 patients with ASOPP were divided into 24 h enteral nutrition group (group A) and 48 h (48-72 h) enteral nutrition group (B group) according to the order of hospitalization. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.012DOI Listing
February 2019

[Analysis of adverse events of clinical blood use except for the adverse reactions of blood transfusion].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):438-441

Department of Blood Transfusion, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To reduce the occurrence of adverse events of clinical blood use by analyzing the clinical adverse events of blood use except for the adverse reactions of blood transfusion. A retrospective analysis was performed on 294 cases of adverse events of clinical blood use other than adverse blood transfusion reactions in Shijitan hospital from January 2014 to December 2017, and a statistical analysis was made on the types of adverse events of clinical blood use, blood transfusion related departments, and internal and surgical blood use. The incidence of adverse events of clinical blood use was 10. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.011DOI Listing
February 2019

[Diagnostic value of multiplex ligation dependent probe amplification combined with Sanger sequencing in 21-hydroxylase deficiency].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):432-437

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Key Laboratory of Endocrinology, National Health Commission, Beijing 100730, China.

To study the procedure of gene mutation detection in 21-hydroxylase deficiency (21-OHD) patients. The detail clinical and biochemical data of 51 patients with 21-OHD [18 males and 33 females, with an average age of (16.4±9. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.010DOI Listing
February 2019

[Complications of transperineal template-guided prostate mapping biopsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.009DOI Listing
February 2019

[Comparative observation of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia of various sizes].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):423-427

Department of Urology, Guizhou Provincial People's Hospital, Guiyang 550002, China.

To compare the efficiency and safety of thulium laser resection of the prostate-tangerine technique (TmLRP-TT) and transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH) of various sizes. Clinical data of 249 BPH patients received TmLRP-TT or TURP were retrospectively collected. Patients were divided into small prostate group [prostate volume (PV)<40 ml], medium prostate group (40 ml≤PV<80 ml) and large prostate group (PV ≥ 80 ml) based on transrectal ultrasound (TRUS) results. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.008DOI Listing
February 2019

[Activation of GPER inhibts proliferation and autophagy in prostatic epithelial cells].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):419-422

Department of Urology, the First Affiliated Hospital of Guangzhou Medical College, Guangdong Key Laboratory of Urology, Guangzhou 510230, China.

To investigate the effect of G protein-coupled estrogen receptor (GPER) on proliferation and autophagy in prostatic epithelial cells. Cell Counting Kit-8 (CCK8) assay was used to observe the growth of BPH-1 and RWPE-1 cells after treating with or not with estradiol or GPER selective agonist G1. Autophagy was quantified with Western blot and Cyto-ID autophagy detection kit after treating with estradiol, G1 or both G1 and G15 in the same cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.007DOI Listing
February 2019

[Bronchial asthma and obstructive sleep apnea].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):414-415

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.005DOI Listing
February 2019

An International Summit in Human Genetics and Genomics: Empowering clinical practice and research in developing countries.

Mol Genet Genomic Med 2019 Jan;7(1):e00599

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

To help fill the knowledge gap in human genetics and genomics, an International Summit (IS) in Human Genetics and Genomics was conceived and organized by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) as a 5-year initiative, from 2016 to 2020. In its first 3 years, 71 professionals from 34 countries received training. Read More

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http://dx.doi.org/10.1002/mgg3.599DOI Listing
January 2019

The self-perceptions of aging were an important factor associated with the quality of life in Chinese elderly with hypertension.

Psychogeriatrics 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. Read More

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http://dx.doi.org/10.1111/psyg.12400DOI Listing
February 2019

Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.

Respirology 2019 Feb 20. Epub 2019 Feb 20.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.

Background And Objective: This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF).

Methods: A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Read More

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http://dx.doi.org/10.1111/resp.13485DOI Listing
February 2019

Intensity-modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. Read More

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http://dx.doi.org/10.1111/vru.12722DOI Listing
February 2019

Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Sciences and Services, The Royal Veterinary College, North Mymms, Hatfield, AL9 7TA, UK.

Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine-needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body imaging in staging mast cell tumors in the authors' institution enabling evaluation of multiple body areas in one examination. The aim of this study was to compare the CT examinations acquired for staging of mast cell disease to their subsequent liver and spleen cytology findings. Read More

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http://dx.doi.org/10.1111/vru.12717DOI Listing
February 2019

The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM-5.

Int J Methods Psychiatr Res 2019 Feb 20:e1773. Epub 2019 Feb 20.

Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5.

Methods: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria. Read More

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http://dx.doi.org/10.1002/mpr.1773DOI Listing
February 2019

[Alternative Psychoses and Forced Normalization after Seizure Control by Anticonvulsants with Special Consideration of the New Anticonvulsants].

Fortschr Neurol Psychiatr 2019 Feb 20. Epub 2019 Feb 20.

Zentrum für Psychiatrie Südwürttemberg, Klinik für Psychiatrie und Psychotherapie I, Universität Ulm.

In the case of alternative psychosis and forced normalization, the patient alternates between periods of clinically manifest seizures and normal behavior, and other periods of seizure freedom (or significant seizure reduction) accompanied by psychosis or behavioral disturbances. Unlike the clinically defined alternative psychosis, forced normalization is based on EEG findings. In clinical practice and in the literature, both terms are mostly used synonymously, and they also describe the same clinical pictures. Read More

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http://dx.doi.org/10.1055/a-0820-3345DOI Listing
February 2019

Sphincterotomy plus balloon dilation versus sphincterotomy alone for choledocholithiasis: a meta-analysis.

Endoscopy 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background:  Endoscopic sphincterotomy plus balloon dilation (ESBD) is considered to be a promising method for the removal of large common bile duct (CBD) stones. However, when compared with endoscopic sphincterotomy (EST) alone, the efficacy and safety of ESBD remain controversial. This meta-analysis aimed to compare the efficacy and safety of ESBD vs. Read More

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http://dx.doi.org/10.1055/a-0848-8271DOI Listing
February 2019

Digital cholangioscopy-guided laser versus mechanical lithotripsy for large bile duct stone removal after failed papillary large-balloon dilation: a randomized study.

Endoscopy 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background:  Endoscopic papillary large-balloon dilation (EPLBD) allows for the complete removal of large common bile duct (CBD) stones without fragmentation; however, a significant proportion of very large stones and stones floating above a tapering CBD require lithotripsy. Mechanical lithotripsy and cholangioscopy-guided laser lithotripsy are both effective for stone fragmentation. This study aimed to directly compare, for the first time, the efficacy of these two techniques in terms of stone clearance rate, procedure duration, patient radiation exposure, and safety. Read More

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http://dx.doi.org/10.1055/a-0848-8373DOI Listing
February 2019

Effectiveness of Insulin Analogs Compared with Human Insulins in Pregnant Women with Diabetes Mellitus: Systematic Review and Meta-analysis.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):104-115. Epub 2019 Feb 20.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1676510DOI Listing
February 2019

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):84-89. Epub 2019 Feb 20.

Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, CE, Brazil.

Objective:  To compare low doses of pethidine with dipyrone in labor analgesia.

Methods:  In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients, with very painful uterine contractions and exhibiting uterine cervix dilatation ≥ 5 cm, were selected to receive a single intravenous dose of either 0.25 mg/kg of pethidine ( = 100) or of 25 mg/kg of dipyrone ( = 100). Read More

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http://dx.doi.org/10.1055/s-0038-1676509DOI Listing
February 2019

Using Electronic Health Records to Identify Adverse Drug Events in Ambulatory Care: A Systematic Review.

Appl Clin Inform 2019 Jan 20;10(1):123-128. Epub 2019 Feb 20.

Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States.

Objective:  We identified the methods used and determined the roles of electronic health records (EHRs) in detecting and assessing adverse drug events (ADEs) in the ambulatory setting.

Methods:  We performed a systematic literature review by searching PubMed and Google Scholar for studies on ADEs detected in the ambulatory setting involving any EHR use published before June 2017. We extracted study characteristics from included studies related to ADE detection methods for analysis. Read More

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http://dx.doi.org/10.1055/s-0039-1677738DOI Listing
January 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019

Man and the Microbiome: A New Theory of Everything?

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Departments of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 K8AF, Ireland; email:

The gut microbiome is implicated in the pathophysiology of a wide range of psychological disorders. Preclinical studies have provided us with key insights into the mechanisms by which the microbiome influences bidirectional gut-brain communication. There are many signaling pathways involved, including the hypothalamic-pituitary-adrenal axis, immune modulation, tryptophan and serotonin metabolism, bile acid transformation, microbial production of neuroactive compounds, and regulation of the endocannabinoid system. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095432DOI Listing
February 2019

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Geriatric Research, Education, and Clinical Center, Tennessee Valley Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095557DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

Accuracy of Clinical Diagnostic Criteria for Patients with Vascular Ehlers-Danlos Syndrome in a Tertiary Referral Centre.

Circ Genom Precis Med 2019 Feb 20. Epub 2019 Feb 20.

AP-HP, Hôpital Européen Georges Pompidou, Département de Génétique, Centre de Référence des Maladies Vasculaires Rares & INSERM, U970, Paris centre de Recherche Cardiovasculaire-PARCC, Paris, France.

Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare inherited connective tissue disease secondary to mutations within the COL3A1 gene. The diagnosis of vEDS is challenging and patient selection for genetic testing relies on diagnostic criteria, which have never been evaluated.

Methods: All patients seen at a dedicated tertiary referral centre for a suspicion of vEDS between January 2001 and March 2016 were retrospectively included in a diagnostic accuracy study. Read More

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001996DOI Listing
February 2019

Risk Factors for Dental Restoration Survival: A Practice-Based Study.

J Dent Res 2019 Feb 20:22034519827566. Epub 2019 Feb 20.

1 Department of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.

To improve patient dental care, it is necessary to identify possible risk factors for the failing of restorations. This practice-based cohort study investigated the performance and influence of possible risk factors at the level of the practice, patient, tooth, and restoration on survival of direct class II restorations. Electronic patient files from 11 Dutch general practices were collected, and 31,472 restorations placed between January 2015 and October 2017 were analyzed. Read More

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http://dx.doi.org/10.1177/0022034519827566DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Local Administration of Magnesium Promotes Meniscal Healing Through Homing of Endogenous Stem Cells: A Proof-of-Concept Study.

Am J Sports Med 2019 Feb 20:363546518820076. Epub 2019 Feb 20.

Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background:: Although many strategies have been developed to modify the biological and biomechanical environment of the meniscal suture repair to improve the chances of healing, the failure rates remain high. Thus, new methods to promote meniscal regeneration and repair are needed.

Hypothesis:: Administration of magnesium (via a repair using magnesium stitches) might enhance recruitment and adherence of endogenous stem cells to the site of the lesion, thereby promoting in situ meniscal regeneration and chondroprotective functions. Read More

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http://dx.doi.org/10.1177/0363546518820076DOI Listing
February 2019

Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.

Annu Rev Biomed Eng 2019 Feb 20. Epub 2019 Feb 20.

Weldon School of Biomedical Engineering and College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA; email:

Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes. Even though formulations with varying abuse-deterrent technologies have been approved, questions remain about their effectiveness. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052155DOI Listing
February 2019

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 Feb;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019

Once-Daily Plazomicin for Complicated Urinary Tract Infections.

N Engl J Med 2019 Feb;380(8):729-740

From the Justus Liebig University, Giessen, Germany (F.M.E.W.); Achaogen, South San Francisco (D.J.C., A.S.K., D.S.C., K.M.K., T.R.K., L.E.C., I.F.), the David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles (L.G.M.), and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance (L.G.M.) - all in California; and Vanderbilt University Medical Center, Nashville (J.P.D.).

Background: The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobacteriaceae.

Methods: We randomly assigned 609 patients with complicated urinary tract infections (UTIs), including acute pyelonephritis, in a 1:1 ratio to receive intravenous plazomicin (15 mg per kilogram of body weight once daily) or meropenem (1 g every 8 hours), with optional oral step-down therapy after at least 4 days of intravenous therapy, for a total of 7 to 10 days of therapy. Read More

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http://dx.doi.org/10.1056/NEJMoa1801467DOI Listing
February 2019

Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.

J Clin Psychiatry 2019 Feb 19;80(2). Epub 2019 Feb 19.

Bipolar Disorder Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR).

Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Read More

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http://dx.doi.org/10.4088/JCP.17m12082DOI Listing
February 2019

Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

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http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

Disparities in the delivery of pediatric oncology nursing care by country income classification: International survey results.

Pediatr Blood Cancer 2019 Feb 20:e27663. Epub 2019 Feb 20.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: In 2014, a task force of the International Society of Paediatric Oncology (SIOP) Paediatric Oncology in Developing Countries Nursing Workgroup published six baseline standards to provide a framework for pediatric oncology nursing care in low- and lower-middle income countries (L/LMIC). We conducted an international survey in 2016-2017 to examine the association between country income level and nurses' resporting of conformity to the standards at their respective institutions.

Procedure: Data from a cross-sectional web-based survey completed by nurses representing 54 countries were analyzed (N = 101). Read More

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http://dx.doi.org/10.1002/pbc.27663DOI Listing
February 2019

An explicit microFE approach to investigate the post-yield behaviour of trabecular bone under large deformations.

Int J Numer Method Biomed Eng 2019 Feb 20:e3188. Epub 2019 Feb 20.

Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstr. 78, Bern, CH-3014, Switzerland.

Homogenised finite element (FE) analyses are able to predict osteoporosis-related bone fractures and become useful for clinical applications. The predictions of FE analyses depend on the apparent, heterogeneous, anisotropic, elastic and yield material properties, which are typically determined by implicit μFE analyses of trabecular bone. The objective of this study is to explore an explicit μFE approach to determine the apparent post-yield behaviour of trabecular bone, beyond the elastic and yield properties. Read More

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http://dx.doi.org/10.1002/cnm.3188DOI Listing
February 2019

A Phase 3, Randomized, Placebo-Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery.

Clin Pharmacol Drug Dev 2019 Feb 20. Epub 2019 Feb 20.

Tampa General Hospital, Tampa, FL, USA.

An intravenous (IV) formulation of meloxicam is being studied for moderate to severe pain management. This phase 3, randomized, multicenter, double-blind, placebo-controlled trial evaluated the safety of once-daily meloxicam IV 30 mg in subjects following major elective surgery. Eligible subjects were randomized (3:1) to receive meloxicam IV 30 mg or placebo administered once daily. Read More

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http://dx.doi.org/10.1002/cpdd.666DOI Listing
February 2019

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing.

Small 2019 Feb 20:e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

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http://dx.doi.org/10.1002/smll.201900046DOI Listing
February 2019

Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models.

Macromol Biosci 2019 Feb 20:e1800485. Epub 2019 Feb 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden.

Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. Read More

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http://dx.doi.org/10.1002/mabi.201800485DOI Listing
February 2019

Concurrent Proteomic Fingerprinting and Molecular Analysis Of Cyathostomins.

Proteomics 2019 Feb 20:e1800290. Epub 2019 Feb 20.

Institute for Parasitology and Tropical Veterinary Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Germany.

Rapid, cost-effective, efficient and reliable helminth species identification is of considerable importance to understand host-parasite interactions, clinical disease and drug resistance. Cyathostomins (Nematoda: Strongylidae) are considered to be the most important equine parasites, yet research on this group has been hampered by the large number of 50 morphologically differentiated species, their occurrence in mixed infections with up to 15 species and the difficulties associated with conventional identification methods. Here, MALDI-TOF MS, previously successfully applied to identify numerous organisms, was evaluated and compared with conventional and molecular genetic approaches. Read More

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http://dx.doi.org/10.1002/pmic.201800290DOI Listing
February 2019

Age- and sex-specific reference intervals for hematologic analytes in Chinese children.

Int J Lab Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Introduction: Reference intervals for pediatric laboratory tests need to be interpreted in the context of age- and sex-dependent dynamics. However, few reference intervals for healthy ethnic Han Chinese children have previously attempted to establish using large sample sizes. As such, there are no national hematological standards in China for pediatric reference intervals. Read More

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http://dx.doi.org/10.1111/ijlh.12979DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Effect of UV aging on translucency of currently used esthetic CAD-CAM materials.

J Esthet Restor Dent 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Dentistry, Prosthodontics Department, İzmir Katip Çelebi University, Turkey.

Objectives: To evaluate the relative translucency parameter (RTP) values of computer-aided design (CAD)-computer-aided manufacturing (CAM) materials after UV aging.

Materials And Methods: 70 specimens (n = 10) of Bruxzir Anterior (BA); E.max Cad (EC); Lava Ultimate (LU); Cerasmart (CE); Vita Enamic (VE); Vita Suprinity (VS); Vita Mark II (VM) were prepared (1 mm ± 0. Read More

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http://dx.doi.org/10.1111/jerd.12460DOI Listing
February 2019

Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

Division of Epidemiology & Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, NG5 1PB, Nottingham, UK.

Objectives: To assess how nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) are managed and treated across primary and secondary care.

Design: Population-based pregnancy cohort.

Setting: Medical records (CPRD-GOLD) from England. Read More

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http://dx.doi.org/10.1111/1471-0528.15662DOI Listing
February 2019

HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.

J Appl Microbiol 2019 Feb 20. Epub 2019 Feb 20.

Laboratory of Cellular and Molecular Immunology - Federal University of Health Sciences of Porto Alegre, Av. Sarmento Leite, 245, Centro Historico, 90050-170, Porto Alegre, RS, Brazil.

Aims: The objective of this research was to quantify the levels of circulating HspBP1 and anti-HspBP1 IgG in HIV-infected individuals and to correlate them with CD4 T cell counts and viral load, as well as to determine the kinetics of those proteins during acute phase.

Methods And Results: Sixty serum samples from HIV-positive outpatients, thirty with high viral load and thirty with low viral load were analyzed. The HspBP1and anti-HspBP1 were quantified by ELISA. Read More

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http://dx.doi.org/10.1111/jam.14230DOI Listing
February 2019
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