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    7457 results match your criteria Clinical and experimental rheumatology[Journal]

    1 OF 150

    Ex-vivo inhibited cytokine profiling explains inferior treatment response to golimumab after adalimumab failure in rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Oct 18. Epub 2017 Oct 18.
    Department of Rheumatology, Sint Maartenskliniek; Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Objectives: Clinical data suggest that the response of rheumatoid arthritis patients to treatment with golimumab is much lower among those who switched from adalimumab than among those who switched from etanercept. To elucidate the mechanism behind this difference in response to sequential biologic treatment, we examined the effect of TNF inhibitors on ex vivo cytokine production profiling.

    Methods: In a prospective cohort study, blood samples were obtained from patients before the start of a biologic. Read More

    Effect of the metabolic syndrome on organ damage and mortality in patients with systemic lupus erythematosus: a longitudinal analysis.
    Clin Exp Rheumatol 2017 Oct 18. Epub 2017 Oct 18.
    Department of Medicine, Tuen Mun Hospital, Hong Kong, SAR China.
    Objectives: To study the effect of the metabolic syndrome (MetS) on organ damage and mortality in patients with SLE.

    Methods: Consecutive patients who fulfilled ≥4 ACR criteria for SLE were assessed for the MetS in October 2010. The MetS was defined by the updated joint consensus criteria, using the Asian criteria for central obesity. Read More

    Non-invasive vascular biomarkers in patients with Behçet's disease: review of the data and future perspectives.
    Clin Exp Rheumatol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Pathophysiology; and Joint Academic Rheumatology Program, Medical School of the National & Kapodistrian University of Athens, Greece.
    Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management. Read More

    Anti-adalimumab antibodies in juvenile idiopathic arthritis-related uveitis.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Ophthalmology, University of Helsinki, Helsinki University Hospital, Finland.
    Objectives: To evaluate the association of adalimumab trough levels and anti-adalimumab antibodies with activity of uveitis in juvenile idiopathic arthritis-related uveitis.

    Methods: This was a retrospective observational case series in a clinical setting at the Department of Ophthalmology, Helsinki University Hospital, Finland in 2014-2016. Thirty-one paediatric patients with chronic anterior juvenile idiopathic arthritis-related uveitis in 58 eyes and who had been on adalimumab ≥6 months were eligible for the study. Read More

    A validation study of the Simple Psoriatic Arthritis Screening (SiPAS) questionnaire to screen psoriasis patients for psoriatic arthritis.
    Clin Exp Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Dermatological Clinic, Università Politecnica delle Marche, Ancona, Italy.
    Objectives: To validate in a multicentric cohort of patients a self-administered PsA screening tool, called Simple Psoriatic Arthritis Screening (SiPAS) questionnaire, to screen psoriasis patients for signs and symptoms of PsA.

    Methods: The SiPAS questionnaire was validated in a multicentric Italian cohort of psoriasis patients referred to two rheumatological centres.

    Results: A total of 202 psoriasis patients were screened with SiPAS in the validation study. Read More

    The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
    Objectives: Antibodies directed to citrullinated proteins are highly specific for rheumatoid arthritis (RA). Citrullination is catalyzed by peptidylarginine deiminase (PAD) enzymes. The current study examined the mRNA expression of PADI2 and PADI4 in bone marrow (BM) CD34+ cells from RA patients. Read More

    Pure red aplasia induced by sodium valproate in a patient with Behçet's syndrome.
    Clin Exp Rheumatol 2017 Oct 27. Epub 2017 Oct 27.
    Rheumatology Institute of Lucania (IRel) and Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera; and the Basilicata Ricerca Biomedica (BRB) Foundation, Italy.

    Infliximab for uveitis of Behçet's syndrome: a trend for earlier initiation.
    Clin Exp Rheumatol 2017 Oct 24. Epub 2017 Oct 24.
    Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.
    Objectives: The prognosis of uveitis in Behçet's syndrome (BS) has improved over decades. Whether this is related to the use of more aggressive management strategies is not known.

    Methods: This is a retrospective study of BS patients who received infliximab (IFX) for refractory eye disease between 2003-2015. Read More

    Exacerbation of Behçet's syndrome and familial Mediterranean fever with menstruation.
    Clin Exp Rheumatol 2017 Oct 24. Epub 2017 Oct 24.
    Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.
    Obectives: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. Read More

    Variable impacts of different remission states on health-related quality of life in rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Oct 23. Epub 2017 Oct 23.
    Academic Department of Rheumatology, Division of Immunology, Infection and Inflammatory Disease, Faculty of Life Sciences and Medicine, King's College London, UK.
    Objectives: Targeting remission in rheumatoid arthritis (RA) improves health-related quality of life (HRQoL) and disability. However, the impacts of different remission criteria and durations and their frequencies are uncertain. Our observational study assessed these factors. Read More

    Psychological comorbidities associated with subclinical atherosclerosis in Greek patients with primary Sjögren's syndrome: a potential contribution of sleep impairment.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Physiology, School of Medicine, National and Kapodistrian University of Athens; Department of Pathophysiology, and Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Greece.
    Objectives: Impaired sleep and psychological disorders are increasingly recognised as prevalent comorbidities in patients with primary Sjögren's syndrome (pSS), as well as important contributors of atherosclerosis in the general population. In the current study we sought to explore a potential role of psychological comorbidities in the pronounced atherosclerotic risk of pSS patients.

    Methods: Fifty-nine pSS patients fulfilling the ACR/EULAR criteria completed specific validated questionnaires assessing fatigue, depression, anxiety and sleep disturbances. Read More

    Vitamin D status in spondyloarthritis: results of the ASAS-COMOSPA international study.
    Clin Exp Rheumatol 2017 Nov 16. Epub 2017 Nov 16.
    Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP; and INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, France.
    Objectives: Spondyloarthritis (SpA) encompasses both bone production and bone loss, and the latter is particularly linked to inflammation. Vitamin D deficiency has been associated with several inflammatory conditions (i.e. Read More

    Th17 gene expression in psoriatic arthritis synovial fluid and peripheral blood compared to osteoarthritis and cutaneous psoriasis.
    Clin Exp Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    University of Toronto Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute; Division of Rheumatology, Dept. of Medicine; Institute of Medical Science, University of Toronto, Canada.
    Objectives: The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients and controls.

    Methods: Synovial fluid cells (SFCs) from 14 PsA and 9 OA patients were obtained and stored in TRIzol reagent. Read More

    A high and equal prevalence of the Q703K variant in NLRP3 patients with autoinflammatory symptoms and ethnically matched controls.
    Clin Exp Rheumatol 2017 Oct 6. Epub 2017 Oct 6.
    Sheba Medical Centre, affiliated to the Sackler School of Medicine, Tel Aviv University, Israel.
    Objectives: Cryopyrin associated periodic syndromes (CAPS) comprise a spectrum of autoinflammatory disorders of varying severity caused by mutations in the NLRP3 gene. The NLRP3-Q703K allele has been reported both as a functional polymorphism and as a low penetrance mutation.

    Methods: To describe the clinical phenotype of subjects with the Q703K allele and to report the frequency of this allele among patients with autoinflammatory symptoms and healthy controls. Read More

    Effects and safety of 99Tc-MDP in patients with refractory ankylosing spondylitis: a 2-stage (30-week follow-up) clinical trial.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Rheumatology and Immunology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Objectives: To evaluate the clinical efficacy and safety in patients with refractory ankylosing spondylitis (AS) initiating 99Tc-MDP therapy and explore the mechanisms.

    Methods: Refractory AS patients were enrolled in the clinical trial and received 99Tc-MDP treatments for 3 or 5 courses according to ASAS improvement. Efficacy and safety evaluations were conducted during the follow-up. Read More

    Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging.
    Clin Exp Rheumatol 2017 Oct 23. Epub 2017 Oct 23.
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation (OMRF); Department of Pathology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
    Objectives: Evaluate the presence of minor salivary gland (SG) fibrosis in primary Sjögren's syndrome (pSS) as a function of disease pathology or a consequence of ageing.

    Methods: Subjects with sicca symptoms attending a Sjögren's research clinic were classified by American European Consensus Group (AECG) criteria as either pSS or non-SS (nSS). Discovery (n=34 pSS, n=28 nSS) and replication (n=35 pSS, n=31 nSS) datasets were evaluated. Read More

    High 3-year golimumab survival in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis: real world data from 328 patients.
    Clin Exp Rheumatol 2017 Nov 9. Epub 2017 Nov 9.
    Joint Rheumatology Program, Clinical Immunology-Rheumatology Unit, 2nd Department of Medicine and Laboratory, Hippokration General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
    Objectives: Our primary objective was to study the long-term survival on drug (SOD) of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) treated with golimumab (GLM) in real life settings.

    Methods: This was a retrospective, observational study of all patients treated with GLM in 4 Academic Centres in Greece during a 4-year period (09/2010-06/2014). SOD was analysed using Kaplan-Meier survival analysis, while Cox regression analysis estimating hazard ratios (HRs) for different baseline variables associated with drug discontinuation was performed for each disease. Read More

    Other autoinflammatory disease genes in an FMF-prevalent population: a homozygous MVK mutation and a novel heterozygous TNFRSF1A mutation in two different Turkish families with clinical FMF.
    Clin Exp Rheumatol 2017 Oct 27. Epub 2017 Oct 27.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
    Objectives: No MEFV mutations are detected in approximately 10% of the patients with clinical FMF in populations where the disease is highly prevalent. Causative mutations were searched in other genes in two such families with "MEFV negative clinical FMF".

    Methods: Father and daughter of family A had attacks of fever, abdominal pain and AA amyloidosis. Read More

    Treatment patterns in rheumatoid arthritis after discontinuation of methotrexate: data from the Ontario Best Practices Research Initiative (OBRI).
    Clin Exp Rheumatol 2017 Oct 23. Epub 2017 Oct 23.
    Toronto General Hospital Research Institute, University Health Network, Toronto; Department of Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto; Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.
    Objectives: In active rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX), guidelines support adding or switching to another conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) and/or a biologic DMARD (bDMARD). The purpose of this analysis was to describe treatment practices in routine care and to evaluate determinants of regimen selection after MTX discontinuation.

    Methods: Biologic-naïve patients in the Ontario Best Practice Research Initiatives registry discontinuing MTX due to primary/secondary failure, adverse events, or patient/physician decision were included. Read More

    Incidence and prevalence of axial spondyloarthritis: methodologic challenges and gaps in the literature.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    UCB Pharma, Raleigh, USA.
    Objectives: The incidence and prevalence of axial spondyloarthritis (axSpA), including ankylosing spondylitis (AS) and non-radiographic (nr-)axSpA, have been investigated in multiple populations, though there is a paucity of population-level data. Here, we identify population-based studies in AS and nr-axSpA, and describe the methodologic challenges in conducting these, outlining potential reasons for disparate incidence and prevalence estimates.

    Methods: PubMed and Embase were searched for population-based studies providing incidence and prevalence rates, published in English from 1 Jan 2000-30 Jun 2015. Read More

    Vitamin D and systemic lupus erythematous: a review of immunological and clinical aspects.
    Clin Exp Rheumatol 2017 Nov 14. Epub 2017 Nov 14.
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS AOU San Martino Hospital, Genova, Italy.
    Objectives: To review the relationships between vitamin D status and systemic lupus erythematosus (SLE) concerning immunological, clinical aspects and possible effects of supplementation in disease modulation.

    Methods: The literature was reviewed up to January 2017 for studies regarding the epidemiology, pathogenesis, immunological aspects, clinical implications and supplementation strategies. The focus was mainly on studies with implications on every day clinical practice. Read More

    One year in review 2017: systemic sclerosis.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):3-20. Epub 2017 Sep 29.
    Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Florence, Italy.
    Systemic sclerosis is a rare acquired systemic disease characterised by heterogeneous evolution and outcome. Each year novel insights into the pathogenesis, diagnosis and treatment of this severe disease have been published. We herewith provide our overview of the most significant literature contributions published over the last year. Read More

    Influence of antibody profile in clinical features and prognosis in a cohort of Spanish patients with systemic sclerosis.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):98-105. Epub 2017 Sep 21.
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatología, Hospital Clínic, Barcelona, Spain.
    Objectives: To assess the clinical manifestations and prognosis of Spanish patients with systemic sclerosis (SSc) according to their immunological profile.

    Methods: From the Spanish Scleroderma Study Group or RESCLE (Registro de ESCLErodermia as Spanish nomenclature) Registry we selected those patients in which anti-centromere (ACA), anti-topoisomerase I (ATA), and anti-RNA polymerase III (ARA) antibodies had been determined, and a single positivity for each SSc specific antibody was detected. Demographic, clinical, laboratory, and survival data were compared according to the serologic status of these antibodies. Read More

    Acute oral tetrahydrobiopterin administration ameliorates endothelial dysfunction in systemic sclerosis.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):167-172. Epub 2017 Sep 14.
    Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
    Objectives: Systemic sclerosis (SSc) is a rare, autoimmune disease characterised by endothelial dysfunction, which is associated with peripheral vasculopathy, such as digital ulcers (DU). We sought to determine if acute oral administration of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase, would augment endothelial function in patients with SSc.

    Methods: Twelve SSc patients, of whom a majority had a history of DU, were studied 5 hours after oral BH4 administration (10 mg/kg body mass) or placebo on separate days using controlled, counterbalanced, double-blind, crossover experimental design. Read More

    Health-related outcomes of importance to patients with Takayasu's arteritis.
    Clin Exp Rheumatol 2017 Sep 18. Epub 2017 Sep 18.
    The University of Pennsylvania, Division of Family Medicine, Philadelphia, PA, USA.
    Objectives: The need to include patients' perspectives as key outcomes in clinical trials is widely accepted. No disease-specific patient-reported outcomes have been developed in Takayasu's arteritis. This project was designed to identify outcomes of importance to patients with Takayasu's arteritis during active disease and remission across 2 different cultures. Read More

    Tocilizumab in two children with pansclerotic morphoea: a hopeful therapy for refractory cases?
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):211-213. Epub 2017 Sep 29.
    Paediatric Rheumatology Unit, Department for the Woman and Child Health, University of Padova, Italy.
    Pansclerotic morphoea (PM) is a subtype of juvenile localised scleroderma characterised by severe course with generalised full-thickness skin involvement and possible growth and functional impairment. PM treatment comprises a combination of immunosuppressive agents such as corticosteroids, methotrexate, mycophenolate mofetil, PUVA and antithymocyte globulin and biological agents used in off-label. A possible role of IL-6 in the regulation of firoblast differentiation and stimulation of collagen synthesis has been suggested and in patients with systemic sclerosis (SSc) the treatment with tocilizumab (TCZ) was associated to improvement of skin thickness and joint motion. Read More

    Serum IL-7 as diagnostic biomarker for rheumatoid arthritis, validation with EULAR 2010 classification criteria.
    Clin Exp Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
    Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, and the Leeds Trust Teaching Hospital, Chapel Allerton Hospital, Leeds, UK.
    Objectives: Despite the well-established value of currently used classification criteria for the early diagnosis of rheumatoid arthritis (RA) there is a constant demand for novel biomarkers notably in autoantibody-negative patients. Interleukin 7 (IL-7) has been reported as a candidate diagnostic biomarker based on ACR-1987 criteria. However, clinical practice has moved to using the EULAR 2010 classification criteria. Read More

    Serum chemerin in systemic sclerosis: a novel marker of early diffuse disease?
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):223-224. Epub 2017 Sep 29.
    Dept. of Clinical Sciences and Community Health, Univ. of Milan; Experimental Lab. of Immunological and Rheumatologic Researches, IRCCS Istituto Auxologico Italiano, Milan; Div. of Rheumatology, ASST Istituto Ortopedico Gaetano Pini & CTO, Milan, Italy.

    Clinical and epidemiological differences between men and women with systemic sclerosis: a study in a Spanish systemic sclerosis cohort and literature review.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):89-97. Epub 2017 Sep 18.
    Autoimmune Unit, Department of Internal Medicine, Hospital Universitario Val D'Hebron, Barcelona, Spain.
    Objectives: The low overall prevalence of systemic sclerosis (SSc) and the low proportion of male patients have resulted in a scarcity of studies assessing sex differences in Ssc patients, and contradictory results have often been show among those studies that have been performed.

    Methods: A prospective study was conducted with the Spanish RESCLE register to analyse the influence of gender on survival of SSc patients.

    Results: In total, 1506 SSc patients (1341 women, 165 men) were recruited from 21 centres. Read More

    Optimal concentration range of golimumab in patients with axial spondyloarthritis.
    Clin Exp Rheumatol 2017 Sep 15. Epub 2017 Sep 15.
    Immunology Unit and Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
    Objectives: To investigate the association between serum golimumab (GLM) trough levels, clinical disease activity and treatment response during the first year of therapy in patients with axial spondyloarthritis (axSpA), as well as determining an optimal concentration range of GLM in axSpA.

    Methods: This was an observational prospective study including 49 patients with axSpA monitored during 52 weeks (W52). Serum GLM trough levels were measured by capture ELISA and antidrug antibodies by bridging ELISA at baseline, W24 and W52. Read More

    Long-term treatment of scleroderma-related digital ulcers with iloprost: a cohort study.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):179-183. Epub 2017 Sep 18.
    Rheumatology Unit, Scleroderma Unit, University of Modena and Reggio Emilia, Modena, Italy.
    Objectives: Raynaud's phenomenon and chronic/recurrent digital ulcers (DU) are main features of systemic sclerosis (SSc). Their treatment includes both systemic (i.e. Read More

    One year in review 2017: Behçet's syndrome.
    Clin Exp Rheumatol 2017 Sep 29. Epub 2017 Sep 29.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Turkey.
    A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome measures for clinical trials is continuing. Multimodal imaging using color fundus photography, fluorescein angiography, and optical coherence tomography is essential in visualising diagnostic features, detecting structural changes, and monitoring disease activity and response to treatment in Behçet's uveitis. Read More

    Oesophageal disease in systemic sclerosis: does heritability play a role?
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):86-88. Epub 2017 Oct 2.
    University of Utah, Department of Internal Medicine, Division of Gastroenterology, Salt Lake City, Utah, USA.
    Objectives: In systemic sclerosis (SSc) the most common gastrointestinal tract (GIT) complaint is gastroesophageal reflux disease (GERD), which may contribute to oesophagitis, stricture, Barrett's oesophagus, and oesophageal adenocarcinoma. We used a genealogical resource the Utah Population Database (UPDB) to analyse SSc pedigrees for hereditability of oesophageal disease.

    Methods: SSc, GERD, oesophagitis, stricture, Barrett's, and oesophageal adenocarcinoma were defined by ICD Ninth and Tenth Revision codes. Read More

    Resistin: a possible biomarker of organ involvement in systemic sclerosis patients?
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 106(4):144-150. Epub 2017 Sep 18.
    Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Poland.
    Objectives: Resistin has strong pro-inflammatory and profibrotic properties, which are key pathogenetic processes in systemic sclerosis. We hypothesised that resistin may be associated with organ involvement and inflammatory process in SSc patients. To address this hypothesis, the aim of this study was to define serum resistin levels in SSc patients and control group and determine the correlation between this adipokine and internal organ involvement in SSc patients. Read More

    Comparison of patients with familial Mediterranean fever accompanied with sacroiliitis and patients with juvenile spondyloarthropathy.
    Clin Exp Rheumatol 2017 Sep 26. Epub 2017 Sep 26.
    Department of Paediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Objectives: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease manifesting with self-limited recurrent febrile attacks and polyserositis. Acute recurrent monoarthritis is the most common form of musculoskeletal involvement in FMF; however, up to 5% of FMF patients may develop chronic joint diseases including sacroiliitis. It is difficult to distinguish whether sacroiliitis is a musculoskeletal finding of FMF or whether this is the coexistence of two diseases, FMF and SpA. Read More

    A case of refractory intestinal Behçet's disease treated with tocilizumab, a humanised anti-interleukin-6 receptor antibody.
    Clin Exp Rheumatol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
    We describe a young female patient who had refractory intestinal Behçet's disease that responded to tocilizumab, a humanised anti-interleukin-6 receptor antibody. The patient had suffered from long disease activity courses and was treated with multiple medications, and the disease became refractory when immunosuppressants (e.g. Read More

    The role of catastrophising in rheumatic diseases.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):32-36. Epub 2017 Sep 28.
    Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Pain is a common and debilitating symptom of many rheumatic diseases. Decades of research have shown that psychological factors are critical in shaping the experience of acute and chronic pain. The current review focuses on pain catastrophising, a cognitive and emotional response to pain, and its implication for the assessment and treatment of individuals with rheumatic diseases. Read More

    An overview of pathways encoding nociception.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):40-46. Epub 2017 Sep 29.
    Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
    The nervous system detects and interprets a variety of chemical, mechanical, and thermal stimuli. In the face of tissue injury, local inflammatory products perpetuate ongoing activity and sensitisation of the peripheral nerve termini. This ongoing activity evokes a state of robust spinal facilitation mediated by a number of local circuits, the net effect yielding an enhanced message of nociception to higher centres. Read More

    A RheuMetric physician checklist to quantitate levels of inflammation, damage and distress on 0-10 visual analogue scales.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):21-25. Epub 2017 Sep 28.
    Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
    A physician global assessment of patient status (DOCGL) was designed initially to quantitate inflammatory activity in rheumatoid arthritis (RA) clinical trials, in which patients are selected for high levels of activity. However, in patients seen in routine care with various diagnoses, and even in some RA patients selected for clinical trials, DOCGL also may be affected by joint damage and/or patient distress. To clarify DOCGL on a 0-10 visual analogue scale (VAS), 3 additional 0-10 VAS have been developed to record physician estimates of inflammation (DOCINF), damage (DOCDAM), and distress (DOCSTR) (such as fibromyalgia (FM)/depression). Read More

    Pain and other self-report scores in patients with osteoarthritis indicate generally similar disease burden to patients with rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Sep-Oct;35 Suppl 107(5):88-93. Epub 2017 Sep 28.
    Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
    Objectives: Osteoarthritis (OA) is regarded as a less severe form of arthritis than rheumatoid arthritis (RA) by health professionals and the general public, based largely on laboratory findings of autoantibodies and acute phase reactants. Relatively few studies have reported data from the patient's perspective to compare directly OA versus RA using the same self-report questionnaire measure. We aimed to summarise reports that compare OA versus RA patient pain scores and other indicators of disease burden according to the same self-report questionnaire. Read More

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