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    7538 results match your criteria Clinical and experimental rheumatology[Journal]

    1 OF 151

    Efficient detection of pulmonary arterial hypertension using serum haptoglobin level and cardiac MRI in patients with connective tissue diseases: a pilot study.
    Clin Exp Rheumatol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

    No specific imaging pattern can help differentiate IgG4-related disease from idiopathic retroperitoneal fibrosis: 18 histologically proven cases.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Internal Medicine and Clinical Immunology, CHRU Lille; Centre National de Référence Maladies Systémiques et Auto-Immunes Rares; FHU Immune-Mediated Inflammatory Diseases and Targeted Therapies (IMMINeNT), Lille, France.
    Objectives: Retroperitoneal fibrosis (RPF) is a rare disease, with unknown aetiology (idiopathic RPF: iRPF) in two-thirds of cases. A subset of iRPF may be a manifestation of IgG4-related disease (IgG4-RD). Thus, recognition of IgG4-RD-RPF is crucial to optimise patient's care with iRPF. Read More

    Anti-alpha-enolase antibodies in Behçet's disease: a marker of mucocutaneous and articular disease activity?
    Clin Exp Rheumatol 2018 Feb 7. Epub 2018 Feb 7.
    Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Brazil.
    Objectives: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity.

    Methods: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. IgM AAEA was detected by immunoblotting. Read More

    Long-term effects of the new direct antiviral agents (DAAs) therapy for HCV-related mixed cryoglobulinaemia: a multicentre open-label study.
    Clin Exp Rheumatol 2018 Feb 13. Epub 2018 Feb 13.
    Department Clinical and Surgical Sciences, University of Trieste, Italy.
    Objectives: To investigate the long-term effects and safety of new direct anti-viral agents (DAAs) in patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC) without renal involvement.

    Methods: The study enrolled 22 consecutive patients, 19 received sofosbuvir-based regimen and three patients received other DAAs, individually tailored according to latest guidelines. As of December 2016, the median length of follow-up was 17 months (range 13-21). Read More

    The initial predictors of death in 153 patients with ANCA-associated vasculitis in a single Korean centre.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Objectives: We estimated the cumulative patient survival rates, the causes of death and the initial predictors of death in Korean patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA).

    Methods: We reviewed the medical records of 153 patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We collected clinical and laboratory data including ANCA, Birmingham vasculitis activity score (BVAS), five factor score (FFS) (2009), comorbidities, medications and prognosis (death and relapse). Read More

    Altered gene expression profiles of histone lysine methyltransferases and demethylases in rheumatoid arthritis synovial fibroblasts.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Rheumatology and Project Research Division, Research Centre for Genomic Medicine, Saitama Medical University, Saitama, Japan.
    Objectives: Aberrant histone lysine methylation (HKM) has been reported in rheumatoid arthritis (RA) synovial fibroblasts (SFs). As histone lysine methyltransferases (HKMTs) and demethylases (HKDMs) regulate HKM, these enzymes are believed to be dysregulated in RASFs. The aim of this study is to clarify whether gene expressions of HKMTs and HKDMs are altered in RASFs. Read More

    Comparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Collaborative Research Centre, Shanghai University of Medicine and Health Sciences, Shanghai; and Department of Epidemiology, School of Public Health, Nantong University, Jiangsu Province, P.R. China.
    Objectives: To compare the efficacies of oral glucosamine, chondroitin, the combination of glucosamine and chondroitin, acetaminophen and celecoxib on the treatment of knee and/or hip osteoarthritis.

    Methods: We searched electronic databases including PubMed, Embase, and Cochrane Library and the reference lists of relevant articles published from inception to October 23, 2017. A Bayesian hierarchical random effects model was used to examine the overall effect size among mixed multiple interventions. Read More

    Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
    Clin Exp Rheumatol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital; and Faculty of Medicine and Life Sciences, University of Tampere, Finland.
    Objectives: The proprotein convertase enzyme FURIN is a critical regulator of the anti-inflammatory TGFβ-1 cytokine and peripheral immune tolerance. In T cells, FURIN is co-regulated with IFN-γ and thus highly expressed in T helper 1 type cells. Previous studies have demonstrated that FURIN is upregulated in inflammatory conditions, including atherosclerosis, rheumatoid arthritis and systemic lupus erythematosus. Read More

    Cancer development in Korean patients with ANCA-associated vasculitis: a single centre study.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul; and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Objectives: We investigated the incidence rate and type of cancer, and furthermore, estimated the standardised incidence ratios (SIRs) of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Korea.

    Methods: We retrospectively included 150 patients with AAV [81 patients with microscopic polyangiitis (MPA), 38 with granulomatosis with polyangiitis (GPA) and 31 patients with eosinophilic GPA (EGPA)], and reviewed their medical records. We collected demographic, clinical and laboratory data, and reviewed the use of glucocorticoid and immunosuppressive drugs administered until detection of cancer or last visit. Read More

    Polyarteritis nodosa revisited: a review of historical approaches, subphenotypes and a research agenda.
    Clin Exp Rheumatol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Medicine, University of Cambridge, UK.
    Polyarteritis nodosa (PAN) is a rare form of primary systemic vasculitis with heterogeneous presentations, treatments and disease course. Historical approaches to classification and diagnostic terminology are reviewed. Since differentiation of PAN from microscopic polyangiitis (MPA) and other ANCA vasculitides by the Chapel Hill conference statements, and with hepatitis associated PAN defined as a secondary vasculitis, the phenotyping and subclassification of PAN has received little attention. Read More

    Inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 on RANKL expression in fibroblast-like synoviocytes and osteoclast-like cell formation induced by IL-22 in rheumatoid arthritis.
    Clin Exp Rheumatol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Rheumatology, Shanxi Medical University, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China.
    Objectives: To explore the inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 (l,25(OH)2D3) on receptor activator of nuclear factor-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLSs) and osteoclastogenesis induced by interleukin (IL)-22 in patients with rheumatoid arthritis (RA).

    Methods: Fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLSs) were cultured and stimulated for RANKL expression with IL-22 in the absence or presence of various concentrations of l,25(OH)2D3, and JAK-2 inhibitor or p38 MAPK inhibitor at the optimised time point of IL-22 treatment. The level of RANKL messenger RNA (mRNA) or protein was measured using real-time polymerase chain reaction (RT-PCR) or western blot method. Read More

    Development of systemic sclerosis in transgender females: a case series and review of the literature.
    Clin Exp Rheumatol 2018 Feb 19. Epub 2018 Feb 19.
    Centre for Rheumatology and Connective Tissue Diseases, University College London, UK.
    Objectives: Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease with a female predominance. The reason for the female predilection in SSc may relate to the difference in hormones between the genders. There are no current data on the influence male-to-female sex transition may have in the development of SSc. Read More

    Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG4-related disease and primary Sjögren's syndrome adults from a defined population.
    Clin Exp Rheumatol 2018 Feb 15. Epub 2018 Feb 15.
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
    Objectives: To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS).

    Methods: Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were enrolled. IgG4-RD and pSS disease activity was assessed based on the IgG4-RD responder index (IgG4-RD RI) and EULAR Sjögren's Syndrome Disease Activity Index (ES- SDAI), respectively. Read More

    Socio-economic inequalities in occurrence and health care costs in rheumatic and musculoskeletal diseases: results from a Spanish population-based study including 1.9 million persons.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Rheumatology, Maastricht University, School for Public Health and Primary Care, Maastricht University Medical Centre, the Netherlands.
    Objectives: To explore and compare the impact of socio-economic deprivation on the occurrence of the major rheumatic and musculoskeletal diseases (RMDs) and health care costs.

    Methods: Data on diagnoses, socio-demographics and health care costs of the entire adult population of the Basque Country (Spain) was used. Area deprivation index included five categories (1 to 5 (most deprived)). Read More

    Molecular recognition patterns of anti-topoisomerase I-antibodies in patients with systemic sclerosis before and after autologous stem cell transplantation.
    Clin Exp Rheumatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Internal Medicine II, University of Tübingen, Germany.
    Objectives: To evaluate the effect of autologous stem cell transplantation (aSCT) on antibody (ab) reactivity towards linear epitopes of topoisomerase-I (topo-I/Scl70) in patients with systemic sclerosis (SSc) and to correlate antibody reactivities with clinical outcome after aSCT.

    Methods: Fourteen anti-topo-I/Scl70-positive SSc-patients were analysed before and after non-myeloablative aSCT. Five patients showed ongoing good response (group 1), 9 had primarily responded but later relapsed or did not respond (group 2). Read More

    Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Genetics, University of Delhi South Campus, New Delhi, India.
    Objectives: ARL15 is a novel susceptibility gene identified in a recent GWAS in a north Indian rheumatoid arthritis (RA) cohort. However, the role of ARL15 or ARF family genes in RA aetiology remains unknown. Therefore, we aimed to i) establish the expression of ARL15 in rheumatoid arthritis synovial fibroblasts (RASF) and ii) its functional characterisation by assessing its effects on major inflammatory cytokines and interacting partners using a knockdown approach. Read More

    Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in American and Israeli rheumatoid arthritis patients.
    Clin Exp Rheumatol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Internal Medicine H, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
    Objectives: Psychological stress is thought to play a major role in the development and exacerbation of autoimmune diseases in general, as well as in rheumatoid arthritis (RA) in particular. The aims of the current study are to compare retrospective self-reports of childhood maltreatment and lifetime major life/traumatic experiences of American and Israeli RA patients, using standardised instruments, while adjusting for concomitant mental disorders and psychological distress, in order to rule out their part in the subjective reports, thus addressing the trans-cultural robustness of the association between childhood maltreatment, traumatic experiences and RA.

    Methods: RA patients at the participating study centres were recruited by their physicians, both in Israel and the USA. Read More

    Serum IgG ACPA-IgM RF immune complexes were detected in rheumatoid arthritis patients positive for IgM ACPA.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.
    Objectives: Since the presence of IgM antibodies is a hallmark of ongoing immune response, we aimed to identify immunologically active rheumatoid arthritis (RA) patients by detecting IgM anti-citrullinated protein antibody (ACPA) levels.

    Methods: IgM ACPA levels were determined in the serum of 176 RA patients by enzyme-linked immunosorbent assay, in which parameters of reactivity against citrullinated and non-citrullinated peptides were compared to ensure the specificity. Influence of IgM rheumatoid factor (RF) on IgM ACPA detection was examined by removing IgG, using protein G-conjugated beads, or by purifying ACPA, using citrullinated peptide-conjugated beads. Read More

    Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.
    Objectives: The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. Read More

    Increased remodelling of interstitial collagens and basement membrane is suppressed by treatment in patients with rheumatoid arthritis: serological evaluation of a one-year prospective study of 149 Japanese patients.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Hiroshima, Japan.
    Objectives: This prospective study aimed to use serological biomarkers for evaluation of, connective tissue turnover, in a population of 149 Japanese patients with rheumatoid arthritis (RA). It was aimed to investigate how the connective tissue was affected by treatment at follow-up after 1 year (+/- 6 weeks) with either methotrexate (n=23) alone, or in combination with: adalimumab (n=49), tofacitinib (n=27) or tocilizumab (n=50).

    Methods: Clinical characteristics were collected and connective tissue turnover, was evaluated by 4 serological biomarkers: C1M and C3M reflect degradation of types I and III collagen in interstitial tissue; C4M, reflecting degraded type IV collagen of the basement membranes; and CRPM, a marker of degraded C-reactive protein. Read More

    The association of endothelial nitric oxide synthase gene single nucleotide polymorphisms with paediatric systemic lupus erythematosus.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Division of Paediatric Rheumatology, The Affiliated Children's Hospital, Capital Institute of Paediatrics, Beijing, China.
    Objectives: Endothelial nitric oxide synthase (eNOS) is a type of nitric oxide synthase that mainly exists in the endothelium. It produces nitric oxide (NO) to regulate the function of endothelial cells. Endothelial dysfunction and increased NO metabolites have been shown in animal models of lupus and in lupus patients, so eNOS gene polymorphisms may be important in the pathogenesis of SLE. Read More

    Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry.
    Clin Exp Rheumatol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
    Objectives: Depression is more common in patients with systemic lupus erythematosus (SLE) compared to the general population. However, few studies have investigated risk factors of depression in SLE patients, and the results are inconsistent. This study evaluated the prevalence of, and risk factors for, depression in ethnically homogeneous Korean SLE patients. Read More

    Increased circulating CD14brightCD16+ intermediate monocytes are regulated by TNF-α and IL-6 axis in accordance with disease activity in patients with rheumatoid arthritis.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
    Objectives: Although circulating CD14brightCD16+ monocyte subsets are increased in inflammatory disease, the pathogenesis of the increase in the inflammatory condition of the cells is still unclear and the relationship to cytokines is unknown particularly in rheumatoid arthritis (RA). The purpose of this study was to investigate the influence anti-cytokine treatment has on CD14brightCD16+ monocytes in patients with RA.

    Methods: Thirty-two RA patients and 14 healthy volunteers (HV) were enrolled in this study. Read More

    An increased major vessel uptake by 18F-FDG-PET/CT in NIH criteria clinical inactive patients with Takayasu's arteritis.
    Clin Exp Rheumatol 2018 Feb 7. Epub 2018 Feb 7.
    Department of Clinical Immunology, Xijing Hospital, The Fourth Military Medical University; Department of Cell Biology, Fourth Military Medical University; National Translational Science Center for Molecular Medicine, Xi'an, Shaanxi Province, China.
    Objectives: The commonly adopted method of defining active disease in Takayasu's arteritis (TAK) is the definition used by the US National Institutes of Health (NIH). A gold standard in imaging techniques for assessing disease activity in TAK has not been clearly established and the creation of practical and valid tools represents a challenge. To assess whether 18F-FDG-PET/CT and NIH criteria show a good level of agreement in assessing disease activity of TAK patients. Read More

    IL-6 receptor inhibition modulates type III collagen and C-reactive protein degradation in rheumatoid arthritis patients with an inadequate response to anti-tumour necrosis factor therapy: analysis of connective tissue turnover in the tocilizumab RADIATE.
    Clin Exp Rheumatol 2018 Jan 31. Epub 2018 Jan 31.
    Nordic Bioscience, Herlev, Denmark.
    Objectives: The objective of this study was to examine the tissue degradation in response to anti-IL6 receptor treatment in rheumatoid arthritis (RA) patients which are anti-TNF-α inadequate responders.

    Methods: RADIATE was a randomised, double-blinded, placebo-controlled, parallel-group, phase III trial. RA patients with previous inadequate response to anti-TNFα therapy (n=299) were randomly assigned to tocilizumab 4 or 8 mg/kg with methotrexate (10-25 mg weekly) or placebo with methotrexate. Read More

    Long-term continuation of methotrexate therapy in giant cell arteritis patients in clinical practice.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):173. Epub 2018 Feb 6.
    Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IDISSC), Hospital Clinico San Carlos, Madrid, Spain.

    One year in review 2017: spondyloarthritis.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):1-14. Epub 2018 Feb 5.
    GenOMeC PhD, University of Siena; and Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
    The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arthritis, which can occur in people following gastrointestinal or genitourinary infections and undifferentiated SpA, that does not meet the diagnostic criteria of the other subgroups at onset, but that may evolve to do so later. Read More

    Gout in Duke Federico of Montefeltro (1422-1482): a new pearl of the Italian Renaissance.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):15-20. Epub 2018 Jan 31.
    Institute of Evolutionary Medicine, University of Zurich, Switzerland.
    The article examines the truthfulness of historical accounts claiming that Renaissance Duke Federico of Montefeltro (1422-1482) suffered from gout. By direct paleopathological assessment of the skeletal remains and by the philological investigation of historical and documental sources, primarily a 1461 handwritten letter by the Duke himself to his personal physician, a description of the symptoms and Renaissance therapy is offered and a final diagnosis of gout is formulated. The Duke's handwritten letter offers a rare testimony of ancient clinical self-diagnostics and Renaissance living-experience of gout. Read More

    Disease activity and dropout in young persons with juvenile idiopathic arthritis in transition of care: a longitudinal observational study.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):163-168. Epub 2018 Jan 31.
    Department of Paediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands.
    Objectives: Reaching a certain age, juvenile idiopathic arthritis (JIA) patients in paediatric care are transferred to adult care. An increased disease activity after transfer and increased dropout has been suggested, however, evidence is scarce. Our aim is to determine whether the process of transition is associated with increased disease-activity and dropout, and to identify associated factors. Read More

    Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Rheumatology, Leiden University Medical Center, The Netherlands.
    Objectives: Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). Here, we studied binding of ACPA-IgG immune complexes (IC) to individual Fc gamma receptors (FcγR) to identify potential effector mechanisms by which ACPA could contribute to RA pathogenesis.

    Methods: ACPA-IgG1 and control IgG1(IgG1 depleted of ACPA-IgG1) were isolated from plasma and synovial fluid (SF) of RA patients by affinity chromatography using CCP2 peptides. Read More

    Interferon regulatory factor 5 is a potential target of autoimmune response triggered by Epstein-barr virus and Mycobacterium avium subsp. paratuberculosis in rheumatoid arthritis: investigating a mechanism of molecular mimicry.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy.
    Objectives: Rheumatoid arthritis (RA) is a chronic disease characterised by a pro-inflammatory cytokines linked erosive joint damage and by humoral and cellular response against a broad range of self-peptides. Molecular mimicry between Epstein-Barr virus (EBV), Mycobacterium avium subsp. paratuberculosis (MAP) and host peptides has long been regarded as an RA pathogenetic mechanism. Read More

    Associations between the SLC22A12 gene and gout susceptibility: a meta-analysis.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, China.
    Objectives: The aim of this study is to explore whether the polymorphisms of rs475688 and rs3825016 in the solute carrier family 22 member 12 (SLC22A12) gene are associated with the susceptibility to gout or hyperuricaemia.

    Methods: Relevant studies were enrolled by searching databases systematically. The pooled odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the associations. Read More

    Impact of vasculitis on employment and income.
    Clin Exp Rheumatol 2018 Jan 10. Epub 2018 Jan 10.
    Vasculitis clinic, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
    Objectives: Work disability associated with rheumatic diseases accounts for a substantial financial burden. However, few studies have investigated disability among patients with vasculitis. The purpose of this study was to examine the impact of vasculitis on patient employment and income. Read More

    Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Hospital Campus de la Salud, Complejo Hospitalario Universitario, Granada, Spain.
    Objectives: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity.

    Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10. Read More

    Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis.
    Clin Exp Rheumatol 2018 Jan-Feb;36(1):171-172. Epub 2018 Jan 15.
    Musculoskeletal Research Unit, University Hospital Southampton NHS Foundation Trust, and NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, UK.

    The Janus kinase inhibitor tofacitinib inhibits TNF-α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
    Objectives: Gliostatin (GLS) is known to have angiogenic and arthritogenic activity, and GLS expression levels in serum from patients with rheumatoid arthritis (RA) are significantly correlated with the disease activity. Tofacitinib is a novel oral Janus kinase (JAK) inhibitor and is effective in treating RA. However, the mechanism of action of tofacitinib in fibroblast-like synoviocytes (FLSs) has not been elucidated. Read More

    Hypoalbuminaemia in antineutrophil cytoplasmic antibody-associated vasculitis: incidence and significance.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, China.
    Objectives: Hypoalbuminaemia has been proved to be a biomarker of poor prognosis in many diseases. The objective of this study was to investigate the significance of hypoalbuminaemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

    Methods: Data of 117 AAV patients were analysed retrospectively. Read More

    Tocilizumab after a first-line with anti-TNF in rheumatoid arthritis: a cost-consequence analysis in the Italian setting.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Rheumatology, Gaetano Pini Institute, Milan, Italy.
    Objectives: Switching to a different mechanism of action in rheumatoid arthritis (RA) patients after a first anti-TNF-α has proved to be effective. The objective of this study was a health economic assessment in Italy.

    Methods: The study was conducted using a pharmacoeconomic model with a 3-year time horizon. Read More

    Amylin in the insulin resistance of patients with rheumatoid arthritis.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Epidemiology, Genetics & Atherosclerosis Res. Group on Systemic Inflammatory Diseases, and Div.of Rheumatology, Hosp.Univ. Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain; and Univ. of the Witwatersrand, Johannesburg, South Africa.
    Objectives: Amylin, which is co-secreted with insulin, plays a role in glycemic regulation and is impaired in type 2 diabetes. In the present study we assess, for the first time, the implication of amylin in the development of insulin resistance (IR) in rheumatoid arthritis (RA).

    Methods: This was a cross-sectional study involving 361 non-diabetic individuals, 151 patients with RA and 210 sex-matched controls. Read More

    Predict rheumatoid arthritis conversion from undifferentiated arthritis with dynamic contrast-enhanced MRI and laboratory indexes.
    Clin Exp Rheumatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Radiology, Tianjin First Center Hospital, Tianjin, China.
    Objectives: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA).

    Methods: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. Read More

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