7,880 results match your criteria Clinical and experimental rheumatology[Journal]


The mortality rate and causes of death among juvenile idiopathic arthritis patients in Finland.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Children and Adolescents, Oulu University Hospital; Medical Research Centre, University of Oulu and Oulu University Hospital; and PEDEGO Research Unit, University of Oulu, Finland.

Objectives: To explore mortality rates and causes of death in juvenile idiopathic arthritis (JIA) patients in Finland compared with the general population.

Methods: All incident patients with JIA (age <16 years at the index day) during 2000-2014 were collected from the nationwide register maintained by the Social Insurance Institution of Finland and The National Population Registry identified three age-, sex- and residence-matched controls for each case. They were followed up together until 31st Dec 2015. Read More

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February 2019

Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Objectives: Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns. Radiographic progression is not associated with the current disease activity biomarkers. We investigated a matrix metalloproteinase mediated metabolite of C-reactive protein (CRPM) and two biomarkers of citrullinated vimentin (VICM and anti-MCV) as novel biomarkers of disease activity. Read More

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February 2019

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

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February 2019

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: To investigate ex-vivo drug-inhibited cytokine production before the start of a biological DMARD (bDMARD) as predictor of treatment response in rheumatoid arthritis (RA).

Methods: In a prospective RA cohort study [BIO-TOP], blood samples were obtained from patients before the start of a bDMARD (abatacept, adalimumab, etanercept, rituximab or tocilizumab). Peripheral blood mononuclear cells were pre-incubated for 1 hour with the therapeutic in-vivo concentration of the bDMARD and stimulated for 24 hours with heat-killed Candida albicans or Pam3Cys. Read More

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February 2019

Clinical features of systemic sclerosis patients with anti-RNA polymerase III antibody in a single centre in Spain.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Unit of Systemic Autoimmune Diseases, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Objectives: To evaluate the clinical features and survival of patients with positive anti-RNA polymerase III (anti-RNAP III) in a Spanish single centre.

Methods: We analysed 221 patients with SSc according to LeRoy and Medsger criteria. Twenty-six patients with positivity for anti-RNAP III antibodies were compared with 195 negative patients. Read More

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February 2019

Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis.

Clin Exp Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

UCL Centre for Nephrology, Royal Free Hospital, London, UK.

Objectives: We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital.

Methods: Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK.

Results: The incidence of anti-MPO positivity in patients without AAV was 39. Read More

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February 2019

Adult-onset Still's disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

Objectives: Adult-onset Still's disease (AOSD) is an inflammatory disorder characterised by sustained fevers, arthritis, and skin involvement. Interstitial lung disease (ILD) is a rare manifestation, and its clinical characteristics have yet to be determined.

Methods: We sought to examine the clinical characteristics of AOSD-associated ILD. Read More

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February 2019
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A probability score to aid the diagnosis of suspected giant cell arteritis.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Southend University Hospital NHS Trust, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK.

Objectives: We propose a GCA probability score intended to help to risk-stratify patients referred by general practitioners with suspected GCA into those with high probability of GCA versus low probability of GCA. In this pilot study we evaluated the diagnostic accuracy of this proposed scoring system.

Methods: A scoring system was proposed based on clinical experience. Read More

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February 2019
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Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Ctr.of Orthopaedics, Chinese Academy of Medical Sciences; Beijing Key Lab. for Genetic Res.of Skeletal Deformity; Dept.of Central Laboratory, Peking Union Medical College Hosp., Peking Union Med. College and Chinese Academy of Med.Science.

Objectives: To evaluate the clinical efficacy of bisphosphonates treatment for spinal bone marrow oedema (BME) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.

Methods: SAPHO syndrome patients presenting to Peking Union Medical College Hospital from 2015 to 2016 were recruited. Patients were administered pamidronate disodium 1 mg/kg/d intravenously, for 3 days, at baseline and 3 months later. Read More

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February 2019

Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology, Department of Medicine, University of Ulsan, College of Medicine, Asan Medical Centre, Seoul, Korea.

Objectives: To investigate the effect of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis.

Methods: Patients with RA who were newly diagnosed with osteoporosis (T-score ≤ -2.5) between 2010 and 2017 were included. Read More

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February 2019

IL-35 prevent bone loss through promotion of bone formation and angiogenesis in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology and Immunology, the First Affiliated Hospital of China Medical University, Shenyang, China.

Objectives: Angiogenesis in bone and osteogenesis appear to be closely linked, suggesting the existence of molecular crosstalk between pro-angiogenic molecules and osteoblasts. The pro-angiogenic molecules vascular endothelial growth factor (VEGF) with its receptors Flt-1, Flk-1 and fibroblast growth factor (FGF)-2 play a crucial role in born formation, an early and critical event in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-35 is demonstrated to be an anti-inflammatory cytokine in RA. Read More

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February 2019

Clinical features of thirty-two patients with anti-melanoma differentiation-associated gene 5 antibodies.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology and Immunology of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies.

Methods: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed.

Results: Of the 32 anti-MDA5 antibody-positive patients, eleven patients were clinically diagnosed with interstitial pneumonia with autoimmune features (IPAF), ten patients were diagnosed with clinically amyopathic dermatomyositis (CADM), six patients were diagnosed with dermatomyositis (DM) and five patients were diagnosed with anti-synthetase syndrome (ASS). Read More

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February 2019

Rate of serious infections in spondyloarthropathy patients treated with anti-tumour necrosis factor drugs: a survey from the Italian registry GISEA.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Rheumatology Unit, University of Bari, Italy.

Objectives: To determine the incidence of serious infections (SIs) among the spondyloarthropathy (SpA) patients from the "Gruppo Italiano per lo Studio delle Early Arthritis" (GISEA) registry and treated with tumour necrosis factor (TNF) inhibitors (TNFIs), and to identify the factors associated with the development of the infections.

Methods: This observational study on 3321 GISEA-registered SpA patients collected real-world demographic and clinical data relating to their biological drug treatments. The overall incidence of infections was analysed by type of SpA. Read More

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February 2019

The effect of JAK1/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Klinikum der Universität München, Munich, Germany.

Numerous cytokines have been implicated in the pathogenesis of inflammatory diseases, and their dysregulation is a main feature of rheumatoid arthritis (RA). Cytokines stimulate signal transduction through several intracellular pathways, including Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways, leading to changes in cell activation, proliferation and survival. Consequently, agents that selectively target elements of the JAK/STAT pathways have received significant attention in recent years as potential new treatments for the disease. Read More

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February 2019

What are the main barriers to achieve minimal disease activity in psoriatic arthritis in real life?

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine, Division of Rheumatology, University of Ottawa Faculty of Medicine, Ottawa Hospital Research Institute, Canada.

Objectives: Minimal disease activity (MDA) is an important target in patients with psoriatic arthritis (PsA), however it is also criticised for having a low threshold for patient reported outcomes (PRO).The aim of the study was to assess the prevalence of MDA and its components in patients with PsA and to evaluate disease characteristics and patterns in patients with or without MDA (MDA+ or MDA-).

Methods: PsArt-ID (Psoriatic Arthritis-International Database) is a prospective, multicentre web-based registry. Read More

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February 2019
3 Reads

A psychoeducational intervention is a treatment for fibromyalgia syndrome.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):98-104. Epub 2019 Feb 8.

Department of Surgical, Medical and Molecular Pathology, Critical and Care Medicine, University of Pisa, Italy.

Although the mechanisms underlying fibromyalgia are not yet clear, many attempts have been made to implement pharmacological therapy and help patients manage its psychological and physical symptoms. Recent evidence has shown that an interdisciplinary multidimensional approach encompassing psychological factors, emotion regulation strategies and education on illness is more effective in improving quality of life, both in the short- and long-term, than usual treatments alone. The purpose of this review is to provide an updated overview of the available literature regarding the role of psychoeducation on fibromyalgia symptoms and health outcomes. Read More

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February 2019
4 Reads
2.724 Impact Factor

Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):75-80. Epub 2019 Feb 8.

NeuroMuscularFunction/Research Group, School of Exercise & Sport Sciences, Department of Medical Sciences, University of Turin, Italy.

Objectives: Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. Read More

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February 2019
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Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical study.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):63-69. Epub 2019 Feb 6.

Department of Rheumatology, ASST Fatebenefratelli-Sacco, Milan, Italy.

Objectives: Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect. Read More

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February 2019
2 Reads

Fibromyalgia and the concept of resilience.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):105-113. Epub 2019 Feb 8.

Clinical and Oncological Psychology, Città della Salute e della Scienza Hospital of Turin, Turin, Italy.

The concept of resilience varies according to the context in which it is used. Resilience is broadly defined as a protective factor that makes people less vulnerable to future adverse life events, in this implying the previous occurrence of an adverse event that has to be confronted before individual equilibrium can be restored. This definition can be applied to fibromyalgia and other chronic pain situations. Read More

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February 2019
4 Reads

One year in review 2019: fibromyalgia.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):3-10. Epub 2019 Feb 6.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Fibromyalgia is characterised by chronic pain, fatigue and functional symptoms. Its aetiopathogenesis is still a matter of debate, but various pharmacological and non-pharmacological therapies are currently available for its treatment. We review the literature concerning the most recent findings related to the aetiopathogenesis, diagnosis, clinical aspects and treatment of FM published between January 2018 and January 2019. Read More

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February 2019
1 Read
2.724 Impact Factor

Fibromyalgia syndrome: under-, over- and misdiagnosis.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8.

Division of Rheumatology, McGill University Health Centre, Quebec, Canada and Alan Edwards Pain Management Unit, McGill University Health Centre, Quebec, Canada.

Fibromyalgia syndrome (FM) is an enigma. During the past three decades, with the gradual acceptance of the validity of FM, it is variously under-, over and misdiagnosed. Evidence-based interdisciplinary guidelines have suggested a comprehensive clinical assessment to avoid this diagnostic conundrum. Read More

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February 2019
2 Reads

The role of patient organisation in fibromyalgia and related syndromes.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):11-12. Epub 2019 Feb 6.

Department of Internal Medicine H, Tel Aviv Sourasky Medical Centre, Israel.

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February 2019
1 Read

T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modulated by hyperbaric oxygen therapy.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):81-89. Epub 2019 Feb 8.

Dipartimento di Biopatologia e Biotecnologie Mediche, Università di Palermo, Italy.

Objectives: Hyperbaric oxygen therapy (HBOT) has been used as treatment for different clinical conditions, including fibromyalgia (FM). HBOT modulates brain activity, ameliorates chronic pain and modifies the ratio of immune cells. Clinical studies have provided evidence that FM is associated with immune system dysregulation. Read More

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February 2019
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Increased expression levels of FcγRIIB on naïve and double-negative memory B cells in patients with systemic sclerosis.

Clin Exp Rheumatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Objectives: In systemic sclerosis (SSc), B cell hyperactivation and abnormality are considered to play an important role in the disease pathophysiology. We aimed to clarify if the abnormal activation of B cells involves inhibitory FcγRIIB on B cells in SSc patients.

Methods: Blood samples were collected from 76 SSc patients (38 limited cutaneous SSc and 38 diffuse cutaneous SSc) and 59 healthy controls. Read More

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January 2019
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Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis.

Clin Exp Rheumatol 2019 Jan 18. Epub 2019 Jan 18.

Research Centre of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Objectives: To assess the efficacy of monoclonal anti-tumour necrosis factor (TNF)-α agents in patients with anterior uveitis (AU) in terms of decrease of recurrences, variation of visual acuity and steroid sparing effect and to identify any demographic, clinical or therapeutic variables associated with a sustained response to monoclonal TNF-α inhibitors.

Methods: Data from patients suffering from AU treated with adalimumab, infliximab, golimumab or certolizumab pegol were retrospectively collected and statistically analysed.

Results: Sixty-nine patients (22 males, 47 females), corresponding to 101 eyes, were enrolled. Read More

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January 2019
1 Read

Current and early life weight and associations with mortality in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Jan 18. Epub 2019 Jan 18.

Medicine Service, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha; and National Data Bank for Rheumatic Diseases, Wichita, USA.

Objectives: Obesity is paradoxically associated with a lower risk of mortality in chronic illnesses including rheumatoid arthritis (RA). Weight loss in patients with poor health, however, may in part explain this observation. This study evaluated the impact of weight early in life and weight loss on mortality in patients with RA. Read More

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January 2019
3 Reads
2.724 Impact Factor

Occurrence and aetiology of gastrointestinal perforation in patients with vasculitis.

Clin Exp Rheumatol 2019 Jan 9. Epub 2019 Jan 9.

Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Objectives: This study aimed to characterise the presenting features and outcomes of patients with vasculitis and gastrointestinal perforation.

Methods: Using a retrospective cohort design, this study included 20 cases with verified vasculitis and gastrointestinal perforation at Mayo Clinic, Rochester, USA, between 1998 and 2017.

Results: Four of the twenty cases experienced vasculitis-induced perforation. Read More

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January 2019
3 Reads

Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6.

Clin Exp Rheumatol 2019 Jan 10. Epub 2019 Jan 10.

Centre for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Objectives: Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc.

Methods: Thirty-five consecutive women with established SSc were involved in this exploratory study. Read More

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January 2019
4 Reads
2.724 Impact Factor

Brain responses to other people's pain in fibromyalgia: a magnetoencephalography study.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):70-74. Epub 2019 Jan 9.

Department of Internal Medicine H, Tel Aviv Sourasky Medical Centre & Sakler School of Medicine, Tel Aviv University, Israel.

Objectives: We investigated whether the central pain symptoms in fibromyalgia syndrome (FM) are related to defective top-down sensorimotor regulation. The pain matrix was activated in a top-down manner by presenting pictures of painful situations while recording brain activity using magnetoencephalography (MEG). We investigated alpha desynchronisation in FM patients and healthy controls in response to pictures depicting pain. Read More

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January 2019
3 Reads

High prevalence of fibromyalgia among Israeli school teachers.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):21-26. Epub 2019 Jan 9.

Internal Medicine H, Tel-Aviv Sourasky Medical Center, Tel Aviv & Sackler School of Medicine, Tel Aviv University, Israel.

Objectives: Fibromyalgia syndrome (FM), characterised by widespread pain and fatigue, has frequently been associated with stress in various models, including workplace related stress. In the current study we have evaluated the prevalence of FM symptoms among Israeli school teachers and have attempted to correlate such symptoms with work-related stress.

Methods: Individuals, all currently employed as school teachers in Israel, were recruited to the study. Read More

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January 2019
2 Reads
2.724 Impact Factor

Evaluation of salivary and plasma microRNA expression in patients with Sjögren's syndrome, and correlations with clinical and ultrasonographic outcomes.

Clin Exp Rheumatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Biomedical and Clinical Sciences, Luigi Sacco University Hospital, Milan, Italy.

Objectives: To correlate the expression of microRNAs (miRNAs) 146a/b, 16, the 17-92 cluster and 181a in salivary and plasma samples taken from primary Sjögren's syndrome (pSS) patients with clinical, laboratory and ultrasound findings.

Methods: Plasma and salivary samples were collected from 28 patients with pSS according to 2012 ACR and/or 2016 ACR/EULAR criteria (27 females, mean age 64.4±10. Read More

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January 2019
2 Reads

Effects of glucocorticoids on B-cell subpopulations in patients with IgG4-related disease.

Clin Exp Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Università Vita-Salute San Raffaele and Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: Glucocorticoids induce prompt clinical improvement in patients with IgG4-related disease (IgG4-RD) but their mechanisms of action in this specific condition are not fully understood. B lymphocytes appear central to IgG4-RD pathogenesis because B-cell depletion with rituximab leads to swift clinical responses. In the present work we aim to assess the effects of glucocorticoids on B-cell subpopulations in patients with IgG4-RD. Read More

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January 2019
6 Reads

Insulin resistance vary across connective tissue diseases patients: comparison between rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis.

Clin Exp Rheumatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Internal Medicine and Rheumatology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.

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January 2019
6 Reads

Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.

Clin Exp Rheumatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions.

Methods: The levels of 54 cytokines and chemokines were measured in the sera of 40 patients with active EGPA, 10 of these patients during inactive disease, 6 patients with HES, 8 with asthma, and 10 healthy controls. Read More

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January 2019
3 Reads

Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort.

Clin Exp Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

Centre for Arthritis and Rheumatic Diseases, St Vincent's University Hospital, Dublin Academic Medical Centre, Dublin, Ireland.

Objectives: The diagnosis of giant cell arteritis (GCA) is primarily a clinical one. Temporal artery (TA) ultrasound (US) has been proposed as a new diagnostic tool. We aimed to assess the performance characteristics of TA US in routine clinical practice. Read More

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January 2019
7 Reads

Real world use of secukinumab for treatment of axial spondyloarthritis and psoriatic arthritis: nationwide results from the ATTRA registry.

Clin Exp Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

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January 2019
9 Reads

Effect of Sinovial High-Low® injections in trapeziometacarpal osteoarthritis.

Clin Exp Rheumatol 2019 Jan-Feb;37(1):166. Epub 2018 Dec 20.

Rheumatology Unit, Department of Medicine, University of Perugia, Italy.

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December 2018
6 Reads

Fibromyalgia in patients with rheumatoid arthritis. A 10-year follow-up study, results from the Oslo Rheumatoid Arthritis Register.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):58-62. Epub 2019 Jan 8.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.

Objectives: To examine cross-sectional and longitudinal relationships between fibromyalgia (FM) and rheumatoid arthritis (RA) disease activity.

Methods: 636 patients in the observational Oslo RA register (ORAR) were invited to a clinical examination in 1999. 28-tender and swollen joint counts (TJC, SJC) and 18-tender points were assessed, the RA disease activity score (DAS-28) calculated. Read More

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January 2019
7 Reads

Correlation between quantitative and semiquantitative magnetic resonance imaging and histopathology findings in dermatomyositis.

Clin Exp Rheumatol 2018 Dec 19. Epub 2018 Dec 19.

Muscle Research Unit, Internal Medicine Service, Hospital Clínic de Barcelona, Universidad de Barcelona IDIBAPS and CIBERER, Barcelona, Spain.

Objectives: The aim of this study was to compare muscle biopsy findings, as well as clinical and analytical features, with those of magnetic resonance imaging (MRI) studies of muscle in patients with dermatomyositis.

Methods: All patients from the Longitudinal Myopathy Cohort of the Hospital Clínic de Barcelona were prospectively included in the study from 2009 to 2016. MRI images of muscle and fascial oedema were compared with muscle pathology results using both quantitative and semi-quantitative scores. Read More

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December 2018
8 Reads

Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA project.

Clin Exp Rheumatol 2019 Jan 3. Epub 2019 Jan 3.

Div. Rheumatology, Univ. Cantabria, Hosp. Univ. Marqués de Valdecilla, Santander; Epidemiology, Genetics and Atherosclerosis Res. Group on Systemic Inflammatory Diseases, Rheumatology Div., IDIVAL, Santander, Spain; Univ.of the Witwatersrand, South Africa.

Objectives: To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD).

Methods: Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. Read More

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January 2019
7 Reads

Tacrolimus combined with corticosteroids effectively improved the outcome of a cohort of patients with immune-mediated necrotising myopathy.

Clin Exp Rheumatol 2019 Jan 2. Epub 2019 Jan 2.

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Objectives: To assess the efficacy and safety of tacrolimus in combination with corticosteroids in patients with immune-mediated necrotising myopathy.

Methods: The medical records of 20 hospitalised patients with immune-mediated necrotising myopathy (IMNM) who had received tacrolimus combined with oral prednisone from January 2014 to August 2017 were retrospectively reviewed. The recruited patients were shifted to the combined therapy because they failed to respond well to monotherapy with oral prednisone. Read More

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January 2019
7 Reads

Rituximab induces a lasting, non-cumulative remodelling of the B-cell compartment.

Clin Exp Rheumatol 2018 Dec 19. Epub 2018 Dec 19.

Immunology Service, Hospital Universitario La Princesa, IIS-IP, Madrid, Spain.

Objectives: Reconstitution of B-cells after their therapeutic depletion with rituximab mimics the ontogeny of the B-cell linage in patients with rheumatoid arthritis. However, little is known about the effects of multiple cycles of treatment on the repletion kinetics and their long-lasting effects on the B-cell compartment. We therefore compared the recovery capacity of the B cell subpopulations between patients who experienced their first cycle of rituximab and those who experienced successive cycles. Read More

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December 2018
7 Reads

Interstitial lung pathology: should we test for autoantibodies to cellular antigens?

Clin Exp Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

Athens Academy, Greece.

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December 2018
1 Read

Cysteine-rich protein 61 as a novel biomarker in systemic lupus erythematosus-associated pulmonary arterial hypertension.

Clin Exp Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.

Objectives: This study aimed to evaluate the level of plasma Cysteine rich 61 (Cyr61) in systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) patients, and to explore the diagnostic and prognostic value of Cyr61 in SLE-PAH.

Methods: Plasma samples were obtained from 54 patients with definite SLE-PAH, 52 SLE-non-PAH patients and 54 healthy controls. Enzyme-linked immunosorbent assay was used to measure plasma Cyr61 concentration, and immunohistochemistry assay was adopted to identify Cyr61 protein expression in lung tissues of monocrotaline (MCT) induced PAH rats at different stages. Read More

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December 2018
3 Reads
2.724 Impact Factor

Attitudes about principle of autonomy in Hispanic patients from a dynamic early rheumatoid arthritis cohort.

Clin Exp Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

Centro de Investigación en Bioética, Universidad Panamericana, Ciudad de México, México.

Objectives: In 2004, we began assembling an incidental cohort of patients with recent-onset rheumatoid arthritis (RA). In February 2018, we performed a cross-sectional study with the objective to investigate patients' attitudes/knowledge regarding the autonomy principle.

Methods: Patients currently attending the cohort (n=146) were invited to participate. Read More

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December 2018
5 Reads

Pain catastrophising worsens RAPID3 in all rheumatologic conditions.

Clin Exp Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

Service de Rhumatologie, Hôtel-Dieu, Nantes, France.

Objectives: To assess RAPID3 in various rheumatologic conditions, and the impact of pain catastrophising on RAPID3.

Methods: A set of questionnaires, including RAPID3 (0-30) and pain catastrophising score (0-52), was given to all outpatients seen in a one-month period: 518 patients fulfilled the questionnaires, including 127 RA (42% taking biologics), and 135 SpA (58% taking biologics).

Results: Mean pain catastrophising was 18. Read More

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January 2019
4 Reads

Analysis of potential determinants for a treat-to-target strategy in psoriatic arthritis patients from a real-world setting.

Clin Exp Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

Academic Rheumatology Unit, Dipartimento di Medicina e Scienze della Salute "Vincenzo Tiberio", Università degli Studi del Molise, Campobasso, Italy.

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December 2018
3 Reads

Serum interleukin-17A level is associated with disease activity of adult patients with dermatomyositis and polymyositis.

Clin Exp Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil.

Objectives: To assess serum interleukin (IL)-17A levels in patients with dermatomyositis (DM) and polymyositis (PM) and correlate them with the demographic, clinical, laboratory and therapeutic data of these diseases.

Methods: This was a cross-sectional, single-centre study that included defined DM and PM patients who were age-, gender- and ethnicity-matched to healthy individuals. Serum IL-17A analysis, as well as analysis for other cytokines (IL-6, TNFα and IFNγ), was performed by multiplex immunoassay. Read More

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December 2018
2 Reads

Ultrasonographic detection of subclinical enthesitis and synovitis: a possible stratification of psoriatic patients without clinical musculoskeletal involvement.

Clin Exp Rheumatol 2018 Dec 19. Epub 2018 Dec 19.

Department of Medical and Biological Sciences, Rheumatology Clinic, University of Udine, Italy.

Objectives: To evaluate the prevalence of articular/extra-articular inflammatory lesions and structural damage on ultrasonography in patients suffering from psoriasis as well as to assess possible correlations between ultrasonographic elementary lesions and clinical features.

Methods: Psoriatic patients without musculoskeletal symptoms and healthy controls (HCs) were recruited. All patients received a blinded extended ultrasonographic examination of 42 joints, 12 entheses and 32 tendons. Read More

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December 2018
3 Reads