7,636 results match your criteria Clinical and experimental rheumatology[Journal]


IgG4-related disease: features and treatment response in a multi-ethnic cohort in Singapore.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Rheumatology and Immunology, Singapore General Hospital; and Duke-NUS Medical School, Singapore.

Objectives: To describe the features and treatment outcomes of IgG4-RD in multi-ethnic patients in Singapore.

Methods: Retrospective study was performed on IgG4-RD patients identified from patient databases in a tertiary hospital.

Results: Fourty-two patients (76% male) were included; 79% fulfilled the 2011 comprehensive diagnostic criteria for IgG4-RD for definite IgG4-RD. Read More

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May 2018
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Systemic lupus erythematosus in PubMed: a review of the articles published in 2016.

Clin Exp Rheumatol 2018 May 29. Epub 2018 May 29.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, University Hospital ¨Virgen de las Nieves¨, Granada, Spain.

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May 2018
1 Read

Vitamin D deficiency in connective tissue disease-associated interstitial lung disease.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Rheumatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To determine and compare the prevalence of vitamin D deficiency in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).

Methods: The level of vitamin D was determined by the serum levels of 1,25(OH)2D3. We evaluated 144 patients in our study, including 53 subjects in the CTD-ILD group and 91 subjects in the CTD group without ILD. Read More

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May 2018
1 Read

Risk factors of relapse following glucocorticoid tapering in IgG4-related disease.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Objectives: To identify risk factors of relapse in IgG4-related disease (IgG4-RD) during glucocorticoid (GC) tapering.

Methods: A total of 27 consecutive patients with IgG4-RD (7 with and 20 without relapse) treated with GC for more than 6 months were enrolled. Baseline characteristics were compared in patients with and without relapse. Read More

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May 2018
1 Read

Sjögren's syndrome: disease activity indexes! Do they make us better clinicians or technicians?

Clin Exp Rheumatol 2018 May 25. Epub 2018 May 25.

Harokopio University of Athens, Greece.

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May 2018
2 Reads

Expression profile of long noncoding RNAs in children with systemic lupus erythematosus: a microarray analysis.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Rheumatology and Immunology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing, China.

Objectives: Long noncoding RNAs (lncRNAs) are reported to play crucial roles in several physiological and biological processes. However, knowledge of lncRNAs in children with systemic lupus erythematosus (cSLE) remains limited. We investigate lncRNA expression profiling of cSLE and explore the potential function of lncRNAs. Read More

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May 2018
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Appropriate cardiovascular disease risk assessment in systemic lupus erythematosus may be lacking in rheumatology practice.

Clin Exp Rheumatol 2018 May 28. Epub 2018 May 28.

Department of Medicine, University of Western Ontario, London, ON, and Division of Rheumatology, Department of Medicine, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada.

Objectives: To determine practices regarding cardiovascular (CV) risk assessment in systemic lupus erythematosus (SLE) amongst rheumatologists.

Methods: A questionnaire assessing preventative strategies, risk assessment, and beliefs regarding SLE and CV disease was sent electronically to 425 members of the Canadian Rheumatology Association. Questions were based on published recommendations for CV risk management. Read More

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May 2018
2 Reads

Prevalence and spectrum of symptomatic pulmonary involvement in primary Sjögren's syndrome.

Clin Exp Rheumatol 2018 May 29. Epub 2018 May 29.

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.

Objectives: The present cross-sectional study aimed to estimate the prevalence of chronic respiratory symptoms in primary Sjögren's syndrome (pSS) and define the clinical, functional and imaging characteristics of symptomatic pulmonary disease in pSS.

Methods: Four hundred and fourteen consecutive pSS patients were interviewed for the presence of chronic respiratory complaints (cough and/or dyspnea). Symptomatic pSS patients without respiratory or other comorbidities underwent further investigation with clinical evaluation and assessment with pulmonary functional testing (PFTs) and chest high resolution CT (hrCT) on inspiratory and expiratory phase. Read More

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May 2018
2 Reads

Rheumatic diseases and pregnancy: a national survey about practice patterns among rheumatologists and obstetricians.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Rheumatology, Dubai Hospital, UAE.

Objectives: Management of rheumatic diseases (RD) is often problematic in pregnant patients, hence the need for guideline implementation. This survey-based study aimed to assess beliefs among obstetricians and rheumatologists about managing RD in pregnant Lebanese patients.

Methods: Questionnaires were completed by a representative sample of rheumatologists and obstetricians practicing throughout Lebanon. Read More

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May 2018
3 Reads

Entheseal involvement in asymptomatic human immunodeficiency virus infected patients: preliminary results of a clinical and ultrasonographic study.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Rheumatology Unit, Department of Medical Sciences, University of Ferrara and S.Anna University Hospital, Ferrara, Italy.

Objectives: As a strong association between human immunodeficiency virus (HIV) infection and spondyloarthritis (SpA) has been hypothesised, our main objective was to explore by power Doppler ultrasonography (PDUS) the presence of subclinical enthesitis in asymptomatic HIV patients. The presence of subclinical synovitis was also evaluated.

Methods: Consecutive asymptomatic HIV patients were studied and compared with asymptomatic HCV patients and healthy controls (HC). Read More

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May 2018
6 Reads

Peripheral nervous system involvement in systemic lupus erythematosus: a review of the evidence.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Medical Science, Section of Rheumatology, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Cona, Ferrara, Italy.

In the past years the peripheral nervous system (PNS) involvement in systemic lupus erythematosus (SLE) has received little attention despite its potential significant impact. The true prevalence of PNS in SLE reported in studies is variable and strongly influenced by American College of Rheumatology (ACR) case definition that includes seven PNS manifestations (acute inflammatory demyelinating polyradiculoneuropathy, autonomic disorder, mononeuropathy, myasthenia gravis, cranial neuropathy, plexopathy and polyneuropathy). Other peripheral manifestations, such as chronic inflammatory demyelinating polyradiculoneuropathy and small fibre neuropathy, not included in the ACR nomenclature, have not been well characterised in SLE. Read More

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May 2018
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Role of serum autoantibodies in blood brain barrier damages in neuropsychiatric systemic lupus erythematosus.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Objectives: The present study was carried out to elucidate the roles of serum autoantibodies in the development of blood-brain barrier (BBB) damages in neuropsychiatric systemic lupus erythematosus (NPSLE).

Methods: Paired serum and CSF samples were obtained from 101 SLE patients when they presented active neuropsychiatric manifestations (69 patients with diffuse psychiatric/neuropsychological syndromes [diffuse NPSLE] and 32 patients with neurologic syndromes or peripheral neuropathy [focal NPSLE]). IgG anti-NR2 subunit of NMDA receptor (anti-NR2), anti-Sm, anti-ribosomal P and IgG anti-cardiolipin in sera and albumin in CSF and sera were measured by ELISA. Read More

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May 2018
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Relationship between cerebrovascular and valvular manifestations in a Serbian cohort of patients with antiphospholipid syndrome.

Clin Exp Rheumatol 2018 May 24. Epub 2018 May 24.

Clinic of Internal Medicine, University Hospital Center Bezanijska Kosa, Belgrade; and Faculty of Medicine, University of Belgrade, Serbia.

Objectives: Antiphospholipid syndrome (APS) may manifest itself as a primary (PAPS) or secondary disease, most commonly in the context of systemic lupus erythematosus (SLE) with various neurological and cardiac manifestations in its occurrence. The objective of this study was to investigate the relationship between cerebrovascular (stroke and transient ischaemic attack (TIA)) and valvular manifestations in a Serbian cohort of APS patients.

Methods: This is cross sectional study of 508 APS patients: 360 PAPS and 148 APS patients associated with SLE (SAPS). Read More

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May 2018
3 Reads

Circulating CD4+CD8+ double-positive T-cells display features of innate and adaptive immune function in granulomatosis with polyangiitis.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):93-98. Epub 2018 May 18.

Department of Rheumatology and Clinical Immunology, University of Lübeck, Germany.

Objectives: To examine functional features of CD4+CD8+ double-positive T-cells in patients with granulomatosis with polyangiitis (GPA) using phenotypic and transcriptomic analysis.

Methods: Staining of cellular surface marker was performed using freshly collected whole blood. For intracellular cytokine staining freshly collected whole blood was stimulated with phorbol myristate acetate and ionomycin. Read More

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May 2018
3 Reads

One year in review 2018: systemic vasculitis.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):12-32. Epub 2018 May 18.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Systemic vasculitis are heterogeneous, complex and disabling disorders. Following the previous annual reviews of this series, this paper gives a brief overview on current knowledge about recent literature on small- and large-vessel systemic vasculitis, with a specific focus on pathogenetic and clinical aspects, novel possible disease-related biomarkers and current and future therapies that are in the pipeline. Read More

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May 2018
3 Reads

Rate of infections in severe necrotising vasculitis patients treated with cyclophosphamide induction therapy: a meta-analysis.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):129-134. Epub 2018 May 18.

Division of Rheumatology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.

Objectives: Infections are common complications of necrotising vasculitis. We aimed to determine the rate of infections in patients with severe necrotising vasculitis treated with cyclophosphamide (CYC) combined with high dose glucocorticoids (GC).

Methods: Searches of MEDLINE, Embase and Cochrane Library databases (1990 to May 2016) were performed. Read More

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May 2018
3 Reads

Distribution patterns of 18F-fluorodeoxyglucose in large vessels of Takayasu's and giant cell arteritis using positron emission tomography.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):99-106. Epub 2018 May 18.

Rheumatology Unit, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, and Università di Modena e Reggio Emilia, Italy.

Objectives: To compare patterns of vascular involvement using 18F-fluorodeoxyglucose-positron emission tomography computed tomography (FDG PET/CT) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK).

Methods: A total of 130 consecutive 18F-FDG PET/CT scans performed during the disease course for evaluating disease activity in 15 GCA and 13 TAK patients were retrospectively examined by two nuclear physicians blinded to clinical data. Standardised uptake values (SUVmax) in 14 vascular districts including all the aortic segments and the main tributaries were measured. Read More

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May 2018
3 Reads

Highlights of the 2nd EUVAS Vasculitis Course.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):3-11. Epub 2018 May 18.

Nephrology Unit, Parma University Hospital, Parma, Italy.

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May 2018
1 Read

Manifestation of granulomatosis with polyangiitis in head and neck.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):78-84. Epub 2018 May 18.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.

Objectives: Granulomatosis with polyangiitis is a rare autoimmune disease of the group of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Involvement of the ear, nose and throat (ENT)-region is only described in a few case series and case reports. The objective of this study is to systematically characterise the ENT-involvement in a large series of GPA patients. Read More

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May 2018
2 Reads

Subclinical aortitis after starting nivolumab in a patient with metastatic melanoma. A case of drug-associated aortitis?

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):171. Epub 2018 May 18.

Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.

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May 2018
7 Reads

One year in review 2018: novelties in the treatment of rheumatoid arthritis.

Clin Exp Rheumatol 2018 May-Jun;36(3):347-361. Epub 2018 May 17.

Rheumatology Unit, Department of Clinical Sciences, University of Ferrara, Italy.

The current approach to treatment of rheumatoid arthritis (RA) includes early and aggressive intervention aiming to reach early and persistent low disease activity and remission. New drugs have improved the therapeutic armamentarium of rheumatologists, providing new options for patients. Beyond these innovations, new evidence has improved the safety of therapies and provided tools for the optimisation of long-term management of RA. Read More

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May 2018
2 Reads

Parasympathetic activity increases with digital microvascular damage and vascular endothelial growth factor in systemic sclerosis.

Clin Exp Rheumatol 2018 May 11. Epub 2018 May 11.

Department of Clinical Medicine, Scleroderma Unit, Sapienza University of Rome, Italy.

Objectives: The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF). Read More

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May 2018
4 Reads

Association between dietary and metabolic factors and IgM antibodies to phosphorylcholine and malondialdehyde in patients with systemic lupus erythematosus and population-based matched controls.

Clin Exp Rheumatol 2018 May-Jun;36(3):428-433. Epub 2018 May 8.

Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, and Division of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.

Objectives: Immunoglobulin M (IgM) antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are implicated in systemic lupus erythematosus (SLE) as markers with potential protective properties. Low IgM anti-PC levels are more common in SLE than in control population. Little is known what influences the levels of these antibodies. Read More

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May 2018
2 Reads

Cell therapies for refractory rheumatoid arthritis.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rheumatoid arthritis (RA), an autoimmune disease, is characterised by a persistent synovitis in the joints and systemic inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and disease-modifying antirheumatic drugs (DMARDs) are widely used to treat RA patients. However, a portion of patients still have inadequate response to traditional medications. Read More

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Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.

Objectives: To determine whether the CD4+CD28null T-cells subpopulation predicts the occurrence of damage in SLE.

Methods: This longitudinal study was conducted in consecutive SLE patients seen every six months in our Rheumatology Department since 2012. Patients in whom CD4+CD28null T-cells had been measured and who had at least one subsequent visit were included in the study. Read More

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May 2018
1 Read

Helicobacter pylori infection in systemic sclerosis: a systematic review and meta-analysis of observational studies.

Clin Exp Rheumatol 2018 Apr 16. Epub 2018 Apr 16.

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, and Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objectives: It has been proposed that Helicobacter pylori (H.pylori) infection causes several extra-gastrointestinal disorders. However, the role of H. Read More

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April 2018
6 Reads

Pattern of muscle involvement in inclusion body myositis: a sonographic study.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Johns Hopkins University, Applied Physics Laboratory, Laurel, MD, USA.

Objectives: Imaging plays a role in myositis assessment by detecting muscle changes indicative of pathology. This study was conducted to determine the ultrasonographic pattern of muscle involvement in patients with inclusion body myositis (IBM) through an assessment of muscle echointensity.

Methods: Sixty-two individuals were consecutively studied, 18 with IBM, 16 with polymyositis or dermatomyositis and 28 normal controls. Read More

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May 2018
2 Reads

Potentially traumatic events, PTSD and post-traumatic stress spectrum in patients with fibromyalgia.

Clin Exp Rheumatol 2018 Apr 24. Epub 2018 Apr 24.

Psychiatric Clinic, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Objectives: Fibromyalgia (FM) is defined as a severe, chronic, non-articular rheumatic condition characterised by widespread musculoskeletal pain, hyperalgesia and generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities. Pain is the predominant symptom, allodynia and hyperalgesia are common signs. Extreme fatigue, impaired cognition and non-restorative sleeping difficulties coexist in addition to other somatic symptoms. Read More

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April 2018
1 Read
2.72 Impact Factor

Successful treatment of a patient with both systemic lupus erythematosus and progressive hepatitis C using immunosuppressive therapy and interferon beta.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Division of Rheumatic Diseases, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.

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May 2018
1 Read

Primary myelofibrosis but not autoimmune myelofibrosis accompanied by Sjögren's syndrome and primary biliary cirrhosis in a patient with trisomy 8 mosaic: a case report and literature review.

Clin Exp Rheumatol 2018 May 10. Epub 2018 May 10.

Department of Rheumatology and Immunology, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Bone marrow fibrosis has been found to be associated with autoimmune disorders, and autoimmune myelofibrosis (AIMF) has been defined. Primary myelofibrosis (PMF), a clonal myeloproliferative disorder, should be distinguished from AIMF which has a good response to steroids, as the former has a high mortality and very bad response to conventional treatment. This case report describes a rare case of PMF accompanied with Sjögren's syndrome (SJS) and primary biliary cirrhosis (PBC), in a patient with trisomy 8 mosaic. Read More

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May 2018
2 Reads

Explorative analyses of protein biomarkers in patients with early rheumatoid arthritis achieving sustained drug-free remission after treatment with tocilizumab- or methotrexate-based strategies: from transcriptomics to proteomics.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, The Netherlands.

Objectives: Previously, we identified networks of co-expressed genes related to achieving sustained drug-free remission (sDFR). The aim of the present exploratory analysis was to identify inflammatory proteins associated with achieving sDFR and their enriched biological pathways, and compare these pathways with those found in the previous transcriptomic analyses.

Methods: Serum samples were used from 60 patients who participated in the U-Act-Early trial and were treated-to-target with tocilizumab plus methotrexate, or tocilizumab or methotrexate; 37 achieved sDFR (≥3 months drug-free) and 23 did not (controls). Read More

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May 2018
3 Reads

Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.

Objectives: The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression. Read More

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May 2018
2 Reads

Prevalence and characteristics associated with dactylitis in patients with early spondyloarthritis: results from the ESPeranza cohort.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Rheumatology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.

Objectives: Dactylitis is a typical feature of psoriatic arthritis. However, dactylitis was included as a spondyloarthritis (SpA) feature for both (axial and peripheral) of the ASAS classification criteria, but data about its prevalence are scarce, especially in patients with a recent onset of the disease. Our objective was to determine the prevalence and characteristics associated with dactylitis in patients with early SpA. Read More

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May 2018
4 Reads

The adenosinergic system: a potential player in the pathogenesis of ANCA-associated vasculitis?

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):143-151. Epub 2018 May 3.

Vth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially lethal autoimmune disease whose pathology comprises disturbed T cell differentiation and functionality accompanied by dysfunctional autoreactive immunoglobulin development, culminating in destructive innate immune response as well. Purines, adenine nucleotides and adenosine in particular, have been elucidated as potent extracellular mediators for fine adjustment of these pivotal processes establishing human immunity. Therefore, the extracellular purinergic microenvironment is under control of ectonucleotidases CD39 and CD73 degrading pro-inflammatory adenosine triphosphate (ATP) to anti-inflammatory adenosine as well as adenosine deaminase bound to CD26 deactivating adenosine. Read More

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May 2018
2 Reads

The role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease patients. A case control study.

Clin Exp Rheumatol 2018 May 10. Epub 2018 May 10.

Department of Audiology, Faculty of Medicine, Tanta University, Egypt.

Objectives: To determine the types and to assess the role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Behçet's disease (BD) patients. Their correlations with disease activity were also considered.

Methods: Thirty patients with BD and thirty apparently sex- and age-matched healthy volunteers were included in this study. Read More

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May 2018
2 Reads

Tapering tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective study.

Clin Exp Rheumatol 2018 Apr 19. Epub 2018 Apr 19.

Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

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April 2018
1 Read

Should over-treatment of axial spondyloarthritis with biologics remain a concern after the issue of the new ASAS criteria? Data from REGISPONSERBIO (Spanish Register of Biological Therapy in Spondyloarthritides).

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Rheumatology Department, University Hospital Bellvitge, Barcelona, Spain.

Objectives: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria.

Methods: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Read More

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May 2018
6 Reads

A case of giant cell arteritis mimicking vertebral dissection on contrast-enhanced magnetic resonance angiography.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):178-179. Epub 2018 Apr 19.

Division of Rheumatic Diseases, National Centre for Global Health and Medicine, Shinjuku, Tokyo, Japan.

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April 2018
2 Reads

The presence of staphylococcal superantigens in nasal swabs and correlation with activity of granulomatosis with polyangiitis in own material.

Clin Exp Rheumatol 2018 Mar-Apr;36 Suppl 111(2):40-45. Epub 2018 May 4.

The Third Department of Pneumonology, National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.

Objectives: Nasal carriage of Staphylococcus aureus and its superantigens (SAg) seem to be a risk factor disease exacerbation in granulomatosis with polyangiitis (GPA). We investigated the association between the presence of SAg in nasal swabs and activity of disease in GPA patients also taking into account correlation with an antimicrobial treatment.

Methods: In a prospective study of a total of 150 GPA patients hospitalised in the period 2009-2016, nasal swabs were examined for the presence of Staphylococcus aureus and SAg. Read More

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May 2018
2 Reads

Interstitial lung disease in patients with mixed connective tissue disease: pilot study on predictors of lung involvement.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Division of Rheumatology, Mayo Clinic, Jacksonville, FL, USA.

Objectives: Mixed connective tissue disease (MCTD) is an immune-mediated systemic disorder characterised by serum autoantibodies against U1-ribonucleoprotein and diverse multisystemic clinical manifestations. Approximately 50% of patients with MCTD develop a radiologic pattern of interstitial lung disease (ILD). Our single centre, cross-sectional study sought to identify clinical and serologic associations of ILD in patients with MCTD which may serve as predictors of lung disease and prognosis. Read More

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May 2018
1 Read

Strong correlation between cancer progression and anti-transcription intermediary factor 1γ antibodies in dermatomyositis patients.

Clin Exp Rheumatol 2018 May 8. Epub 2018 May 8.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objectives: Transcription intermediary factor 1γ (ΤΙF1γ) protein is known as a tumour suppressor that promotes cellular differentiation. Autoantibodies to ΤΙF1γ have a strong clinical association with cancers associated with dermatomyositis (DM). This study aims to identify the clinical characteristics of cancers in anti-ΤΙF1γ antibody-positive adult patients with DM. Read More

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May 2018
4 Reads

Do antimalarials protect against damage accrual in primary Sjögren's syndrome? Results from a Latin-American retrospective cohort.

Clin Exp Rheumatol 2018 Apr 19. Epub 2018 Apr 19.

Department of Rheumatology, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Objectives: To assess the use of antimalarials and to evaluate their association with damage accrual in a Latino-American cohort of patients with primary Sjögren's syndrome (pSS).

Methods: We included 377 patients attending three tertiary referral centers from: Argentina (n=110), Brazil (n=49) and Mexico (n=218). We retrospectively registered demographics, disease duration and use of prednisone (PDN), immunosupressors and antimalarials. Read More

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April 2018
3 Reads

Effects of autonomic dysfunction on exercise tolerance in systemic sclerosis patients without clinical and instrumental evidence of cardiac and pulmonary involvement.

Clin Exp Rheumatol 2018 May 4. Epub 2018 May 4.

Department of Clinical Medicine, Clinical Immunology Unit - Scleroderma Centre, Sapienza University of Rome, Italy.

Objectives: Autonomic dysfunction (AD) in systemic sclerosis (SSc) was already confirmed through heart rate variability (HRV) analysis. Cardio-pulmonary exercise testing (CPET) is a useful tool in early detection of exercise tolerance in SSc patients. Aim of the study was to assess the relationships existing between AD and exercise tolerance. Read More

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May 2018
1 Read

Venous thrombosis and relapses in patients with Behçet's disease. Descriptive analysis from Spanish network of Behçet's disease (REGEB cohort).

Clin Exp Rheumatol 2018 May 3. Epub 2018 May 3.

Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain.

Objectives: To describe the characteristics of patients with Behçet's disease (BD) who presented with venous thrombosis. In addition, we identified the factors associated with this venous involvement and those related with recurrent venous thrombosis.

Methods: Up to January 2015, 544 BD patients from 20 Spanish hospitals had been included in the REGEB (REGistro de la Enfermedad de Behçet as Spanish nomenclature). Read More

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May 2018
5 Reads

Renal involvement in autoinflammatory diseases and inflammasome-mediated chronic kidney damage.

Clin Exp Rheumatol 2018 Jan-Feb;36 Suppl 110(1):54-60. Epub 2018 May 3.

Amyloidosis Research and Treatment Centre, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory process. The deposition of the acute-phase reactant serum amyloid A (SAA) as amyloid causes progressive glomerular and vascular damage and leads to organ failure. Read More

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May 2018
2 Reads

Autoinflammatory diseases as a cause of acute abdominal pain in the emergency department.

Clin Exp Rheumatol 2018 Jan-Feb;36 Suppl 110(1):39-43. Epub 2018 May 3.

Emergency Department, ASST-Fatebenefratelli Sacco University Hospital, Milan, Italy.

Autoinflammatory diseases (AIDs) usually present with acute abdominal pain and fever, both of which are also the main causes of referral in the emergency department. As some patients with acute abdominal pain may be discharged from the emergency department without a definitive diagnosis, it is not surprising that, due to their rarity, most cases of AID remain undiagnosed or are misdiagnosed as acute appendicitis. Indeed, the diagnosis of familial Mediterranean fever and autoinflammatory syndromes requires a high index of suspicion and careful assessment of clinical history. Read More

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May 2018
2 Reads

Neurological manifestations in autoinflammatory diseases.

Clin Exp Rheumatol 2018 Jan-Feb;36 Suppl 110(1):61-67. Epub 2018 May 3.

UO Pediatria 2, G. Gaslini Institute, Genoa, Italy.

Autoinflammatory diseases (AIDs) are a distinct group of diseases characterised by a dysregulation of the innate immune response leading to systemic inflammation. The clinical spectrum of these conditions is extremely variable and possibly every system and tissue can be involved, including the central nervous system (CNS). Indeed, neurological manifestations may dominate the clinical picture from disease onset in some rare conditions. Read More

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The eye involvement in monogenic autoinflammatory diseases: literature review and update.

Clin Exp Rheumatol 2018 Jan-Feb;36 Suppl 110(1):44-53. Epub 2018 May 3.

Research Centre of Systemic Autoinflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Monogenic autoinflammatory diseases (AIDs) are rare entities characterised by improper activation of the innate immune system. This in turn determines recurrent episodes of systemic inflammation characterised by fever, which is variously combined with a wide range of inflammatory manifestations involving the skin, joints, serous membranes, gastrointestinal tract, and central nervous system. As shown by research efforts conducted during the last decade, the eye is not exempt from the systemic inflammatory process and may be involved in almost all of the most frequent AIDs, with several distinct peculiarities. Read More

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