7,924 results match your criteria Clinical and experimental rheumatology[Journal]


Genetic markers associated with clinical and radiographic response in adalimumab plus methotrexate-treated rheumatoid arthritis patients in OPTIMA.

Clin Exp Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Germany.

Objectives: Biologics, including tumour necrosis factor inhibitors such as adalimumab (ADA), have significantly improved outcomes in rheumatoid arthritis (RA). Because the clinical course of RA and response to therapy may be influenced by the genetic background of the patient, the objective of this retrospective parallel-assigned case-control analysis was to evaluate the associations between candidate genetic markers for RA with clinical and radiographic responses to ADA + methotrexate (MTX) or MTX monotherapy in the Optimal Protocol for Treatment Initiation with MTX and ADA (OPTIMA) study.

Methods: Three candidate genetic markers were tested: HLA-DRB1 shared epitope (SE), interleukin 4 receptor (IL4R) single nucleotide polymorphism (SNP) rs1805010, and Fc gamma receptor IIb (FcgRIIb) SNP rs1050501. Read More

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April 2019
2 Reads

Cigarette smoking and clinical response to certolizumab pegol treatment in Hungarian, Czech, and Slovak patients with rheumatoid arthritis: 104-week data from the CIMDORA prospective, non-interventional study.

Clin Exp Rheumatol 2019 Apr 9. Epub 2019 Apr 9.

Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Objectives: Smoking has been shown to influence rheumatoid arthritis (RA) severity and reduce response to some anti-tumour necrosis factor (anti-TNF) therapies. CIMDORA assessed the association between cigarette smoking and clinical effectiveness of certolizumab pegol (CZP) in Hungarian, Slovak, and Czech RA patients.

Methods: CIMDORA was a prospective, non-interventional, 104-week study (Feb 2011-Aug 2015). Read More

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April 2019
3 Reads

Pilot study: non-steroidal anti-inflammatory drugs attenuate active inflammatory sacroiliac joint lesions in patients with early axial spondyloarthritis.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea.

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March 2019
1 Read

IL-6 and TGF-β gene polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.

Objectives: The aim of the study was to explore whether TGF-β and IL-6 gene polymorphisms may be associated with SLE and assess the frequency of HLA-DRB1 alleles in Polish systemic lupus erythematosus (SLE) patients.

Methods: 216 SLE patients and 552 healthy individuals were examined for TGF-β rs1800469 and rs1800470 by TaqMan SNP genotyping assay and for and IL-6(rs2069827 and rs1800795 using the PCR- RFLP method.

Results: An increased frequency of TT genotype and T allele of the TGF β -509 C/T was found in SLE patients (p=0. Read More

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March 2019
1 Read

Adherence in rheumatoid arthritis patients assessed with a validated Italian version of the 5-item Compliance Questionnaire for Rheumatology.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Italy.

Objectives: The 5-item Compliance Questionnaire for Rheumatology (CQR5) proved reliability and validity in respect of identification of patients likely to be high adherers (HAs) to anti-rheumatic treatment, or low adherers (LAs), i.e. taking<80% of their medications correctly. Read More

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March 2019
1 Read

Observational study on the QUality of life of Italian Axial SpondyloARthritis patients (QUASAR): baseline data.

Clin Exp Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

Reumatologia Day Hospital, A.S.S. Gaetano Pini-CTO, Milano, Italy.

Objectives: To describe the baseline characteristics of the patients enrolled in the QUality of life in patients with Axial SpondyloARthritis (QUASAR) study in terms of quality of life (QoL), disease activity, therapy adherence, and work ability in a real-world setting.

Methods: QUASAR is an Italian multicentre, prospective 12-month observational study, including consecutive adult patients classified as axial spondyloarthritis (axSpA) according to the Assessment of SpondyloArthritis international Society criteria for axSpA.

Results: Of 512 patients enrolled in 23 rheumatology centres, 80. Read More

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April 2019
9 Reads

When chest pain is not "just" Tietze's syndrome: a case of non-Hodgkin's lymphoma.

Clin Exp Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona, Italy.

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April 2019
9 Reads
2.724 Impact Factor

Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.

Clin Exp Rheumatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Paediatrics, Division of Rheumatology, The University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, Canada.

Type I interferons (IFN) are a class of inducible and protective cytokines best known for immune defence against viruses and intracellular bacteria. Inappropriate stimulation or defective negative regulation of type I IFN expression however can lead to persistent type I IFN activity with detrimental effects. This is particularly relevant for a class of monogenic autoinflammatory diseases ("type I interferonopathies"), along with many other complex rheumatic diseases such as systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), rheumatoid arthritis (RA) and Sjögren's syndrome (SS). Read More

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March 2019
7 Reads

Risk of congenital anomalies in infants born to women with autoimmune disease using biologics before or during pregnancy: a population-based cohort study.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

University of British Columbia Faculty of Pharmaceutical Sciences, Vancouver; Collaboration for Outcomes Research and Evaluation, Vancouver; and Arthritis Research Canada, Richmond, Canada.

Objectives: To determine the association between perinatal biologic use and congenital anomalies in women with autoimmune disease.

Methods: We linked population-based administrative health data including information on all medications with a perinatal registry in British Columbia, Canada. Women with one or more autoimmune diseases who had pregnancies between January 1st, 2002 and December 31st, 2012 were included. Read More

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March 2019
5 Reads

High cardiovascular risk in mixed connective tissue disease: evaluation of macrovascular involvement and its predictors by aortic pulse wave velocity.

Clin Exp Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

ACURA Rheumatology Clinics, Bad Kreuznach, and Division of Rheumatology and Clinical Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.

Objectives: Macrovascular involvement and cardiovascular (CV) risk has not been sufficiently studied in mixed connective tissue disease (MCTD). In particular, the gold standard assessment method of aortic stiffness carotid-femoral pulse wave velocity (cfPWV) has never been evaluated in patients with this disease. The aims of the present study were therefore to examine cfPWV in MCTD and to evaluate its associations with MCTD-associated markers and traditional CV risk factors. Read More

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April 2019
4 Reads

Aortic angiosarcoma masquerading as inflammatory aortitis.

Clin Exp Rheumatol 2019 Mar 19. Epub 2019 Mar 19.

Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Systémiques Rares, Hôpital Cochin, AP-HP, Paris, and Faculté de Médecine Paris Descartes, Paris, France.

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March 2019
5 Reads
2.724 Impact Factor

Antidrug antibody detection for adalimumab depends on the type of assay used: an experimental approach to help clinicians interpret diagnostic data.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Amsterdam Rheumatology and immunology Center, location Reade, and Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Center, Amsterdam, the Netherlands.

Objectives: To compare different methods of antidrug antibody (ADA) against adalimumab detection in ankylosing spondylitis (AS) patients and the impact of ADA on adalimumab drug levels and mean ASDAS-CRP.

Methods: We used the acid-dissociation-radioimmunoassay (ARIA), antidrug-binding-test (ABT) and a bridging Enzyme-linked Immunosorbent Assay (ELISA) to detect ADA at 4, 12 and 24 weeks of treatment. Patients were divided into groups; all assays negative (All-neg), only ARIA positive (ARIA-only-pos), ARIA and ABT positive, bridging ELISA negative (ARIA/ABT-double-pos) and all assays positive (All-pos). Read More

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March 2019
2 Reads

Pain and bone damage in rheumatoid arthritis: role of leukotriene B4.

Clin Exp Rheumatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Physiology, College of Medicine, Nanchang University, China.

Rheumatoid arthritis is a chronic autoimmune disease characterised by unbearable joint pain as well as bone and cartilage destruction. Although RA development is greatly controlled, the pain and bone damage failed to be relieved and managed. Leukotriene B4 (LTB4) has been proved to play an essential role in the induction of pain and bone damage. Read More

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March 2019
4 Reads

Cardiometabolic risk and subclinical vascular damage assessment in idiopathic inflammatory myopathies: a challenge for the clinician.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Institute of Clinical Physiology CNR, Pisa, Italy.

Objectives: A high prevalence of cardiovascular disease (CVD), not fully explained by the prevalence of traditional risk factors only, is reported in patients with idiopathic inflammatory myopathies (IIMs). Thus, we investigated if novel markers of CVD risk, like carotid diameter and advanced glycated end products, can better predict increased CVD risk in IIM patients.

Methods: We studied 43 consecutive patients diagnosed with IIM. Read More

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March 2019
3 Reads
2.724 Impact Factor

Role of cannabinoid receptor 2 in mediating interleukin-1β-induced inflammation in rheumatoid arthritis synovial fibroblasts.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmaceutical Sciences, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, and Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, USA.

Objectives: Recent studies showed that the expression of cannabinoid receptor 2 (CB2), not CB1, is upregulated at both the mRNA and protein levels in rheumatoid arthritis synovial fibroblasts (RASFs), however, little is known about its endogenous role in pro-inflammatory cytokine signalling in RASFs. Our aim was to investigate the role of CB2 receptor in mediating IL-1β-induced inflammation in human RASFs.

Methods: Human RASFs were pretreated with CB2 selective agonist (JWH-133), followed by stimulation with interleukin-1β (IL-1β, 10 ng/mL). Read More

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March 2019
4 Reads

Are antibodies against La (SSB) no longer useful for the diagnosis of Sjögren's syndrome?

Clin Exp Rheumatol 2019 Apr 2. Epub 2019 Apr 2.

Division of Clinical Immunology and Allergy, Department of Medical Specialties, University Hospital and School of Medicine, Geneva, Switzerland.

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April 2019
2 Reads

Systemic lupus erythematosus is a risk factor for atrial fibrillation: a nation-wide, population-based study.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Objectives: Cardiac involvement is present in more than half of the patients with systemic lupus erythematosus (SLE). However, large-scale studies on the prevalence of atrial fibrillation (AF) in this disease do not exist. We aimed to investigate the incidence and clinical significance of AF in SLE. Read More

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March 2019
4 Reads

Efficacy and safety of certolizumab pegol and golimumab in the treatment of non-infectious uveitis.

Clin Exp Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.

Objectives: The aim of the study was to evaluate the efficacy of golimumab (GOL) and certolizumab pegol (CZP) as additional treatment options for the treatment of uveitis.

Methods: Patients with longstanding uveitis receiving either GOL or CZP were retrospectively evaluated in terms of frequency of ocular flares, drug survival, changes in best corrected visual acuity (BCVA) and steroid-sparing effect.

Results: Twenty-one patients (30 eyes), 17 of whom being female, were enrolled in the study; 16 out of 21 patients had been previously treated with other tumour necrosis factor (TNF)-α blockers. Read More

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April 2019
2 Reads

Study on the association of serum pentraxin-3 and lysosomal-associated membrane protein-2 levels with disease activity in Chinese Takayasu's arteritis patients.

Clin Exp Rheumatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: To evaluate the association between disease activity and serum levels of pentraxin-3 (PTX-3) and lysosomal-associated membrane protein-2 (LAMP-2) as well as the acute reactants in Chinese Takayasu's arteritis (TAK) patients.

Methods: The serum PTX-3 and LAMP-2 levels were tested in 98 TAK patients and 40 age- and gender-matched healthy controls. The disease activity of these TAK patients was assessed according to the National Institute of Health (NIH) and Abatacept in giant cell arteritis and Takayasu's arteritis (AGATA) criteria, respectively. Read More

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March 2019
2 Reads

Vascular stiffness: influencing factors on carotid-femoral pulse wave velocity in systemic lupus erythematosus.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Internal Medicine I, Division of Rheumatology and Immunology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.

Objectives: Patients with systemic lupus erythematosus (SLE) are under increased risk for cardiovascular events (CVE) and mortality. Aortic stiffness, as measured by carotid-femoral pulse wave velocity (cfPWV), has been shown to predict CVE and mortality in the general population. The aim of the present study was to examine the factors associated with cfPWV in patients with SLE and to determine differences of SLE patients in comparison to healthy controls. Read More

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March 2019
2 Reads

A complex pattern of autonomic dysfunction in familial Mediterranean fever. Results from a controlled cross-sectional study.

Clin Exp Rheumatol 2019 Mar 18. Epub 2019 Mar 18.

Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Germany.

Objectives: Autonomic dysfunction (AD) has been described in various chronic inflammatory diseases. Studies of AD in patients with familial Mediterranean fever (FMF) are inconclusive. We aimed to assess AD in a cohort of FMF patients. Read More

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March 2019
4 Reads

Faecal microbiota transplantation for Clostridium difficile infection resulting in a decrease in psoriatic arthritis disease activity.

Clin Exp Rheumatol 2019 Mar 27. Epub 2019 Mar 27.

Centre for Nutrition and Gastrointestinal Disease Research, The University of Adelaide and South Australian Health and Medical Research Institute, and Department of Gastroenterology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.

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March 2019
3 Reads

One year in review 2018: psoriatic arthritis.

Clin Exp Rheumatol 2019 Mar-Apr;37(2):167-178. Epub 2019 Mar 19.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Spondyloarthritis (SpA) is an inflammatory condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features that genetically tend to be associated with the major histocompatibility complex class 1 antigen, HLA-B27, and in which both peripheral and axial joints might be affected. In addition to arthritis, the typical musculoskeletal manifestations are enthesitis and dactylitis. Extraarticular manifestations such as acute anterior uveitis (AAU), psoriasis (PsO) and inflammatory bowel disease (IBD) are also typical of SpA. Read More

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March 2019
1 Read

Adalimumab provides long-lasting clinical improvement in refractory mucocutaneous Behçet's disease without formation of antidrug antibodies.

Clin Exp Rheumatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Immunology and Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Medical Center Rotterdam, the Netherlands.

Objectives: The TNF-blocker adalimumab can be effective in Behçet's disease (BD), a multisystem auto-inflammatory disorder. Unfortunately, the therapeutic efficacy of TNF-blockers can be hampered by the formation of anti-drug antibodies. We present an observational study of adalimumab in refractory BD with measurement of anti-drug antibodies. Read More

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March 2019
2 Reads

Serum soluble programmed cell death protein 1 could predict the current activity and severity of antineutrophil cytoplasmic antibody-associated vasculitis: a monocentric prospective study.

Clin Exp Rheumatol 2019 Mar 11. Epub 2019 Mar 11.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.

Objectives: We investigated whether serum soluble programmed cell death protein 1 (sPD-1) could predict the current activity and severity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on Birmingham vasculitis activity score (BVAS) in patients with AAV.

Methods: Fifty-nine patients from a monocentric prospective cohort of AAV were included. On the same visit-day, blood samples were collected and isolated sera were stored, BVAS and other AAV-related parameters were assessed, and laboratory tests were performed. Read More

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March 2019
1 Read

Epidemiology and management of familial Mediterranean fever in Armenia: national audit from 1999 to 2018.

Clin Exp Rheumatol 2019 Mar 4. Epub 2019 Mar 4.

Operational Research Unit, Operational Centre Brussels, Médecins sans Frontières, Luxembourg.

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March 2019
1 Read

Endovascular embolisation with Amplatzer vascular plug of ruptured pulmonary artery aneurism in Behçet's disease.

Clin Exp Rheumatol 2019 Feb 28. Epub 2019 Feb 28.

Department of Thoracic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

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February 2019
1 Read

Evaluation of the predictive validity of the ASAS axial spondyloarthritis criteria in the DESIR cohort.

Clin Exp Rheumatol 2019 Mar 7. Epub 2019 Mar 7.

Paris Descartes University, Medicine Faculty; APHP, Rheumatology B Department, Cochin Hospital, Paris; INSERM (U1153): Clinical Epidemiology and Biostatistics PRES Sorbonne Paris-Cité, France.

Objectives: To evaluate the predictive validity of the Assessment of SpondyloArthritis international Society (ASAS) axial spondyloarthritis (axSpA), Amor, European Spondylarthropathy Study Group (ESSG) and modified New York (mNY) classification criteria.

Methods: Patients from the DESIR cohort (inflammatory back pain suggestive of axSpA for >3 months but <3 years duration), followed for up to 5 years. Positive predictive value (PPV) of the set of criteria collected at baseline (ASAS, and its arms, Amor, ESSG and mNY: fulfilled/not fulfilled) were tested against the rheumatologist's axSpA diagnosis (fulfilled/not fulfilled) after 5 years of follow-up. Read More

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March 2019
4 Reads

Rationale underlying the measurement of fractional exhaled nitric oxide in systemic sclerosis patients.

Clin Exp Rheumatol 2019 Feb 27. Epub 2019 Feb 27.

L. Sacco Department of Biomedical Sciences, University of Milan, Italy.

Systemic sclerosis (SSc) is an autoimmune disease characterised by tissue fibrosis leading to vascular injury. Nitric oxide (NO) has been implicated in the pathogenesis of autoimmune diseases. A deficiency in basal NO production by the constitutive endothelial isoform of nitric oxide synthase may promote vasoconstriction and vascular wall thickening. Read More

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February 2019
3 Reads

Can ultrasound-detected subclinical synovitis be an indicator of flare recurrence in juvenile idiopathic arthritis remission patients on tapered TNFi?

Clin Exp Rheumatol 2019 Mar 7. Epub 2019 Mar 7.

Department of Rheumatology and Joint and Bone Research Unit, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.

Objectives: Subclinical synovitis is often detected by musculoskeletal ultrasound (MSUS) in juvenile idiopathic arthritis (JIA) patients in clinical remission. The main objective of this prospective, observational, longitudinal, multicentre study was to evaluate the predictive value of MSUS-detected subclinical synovitis in relation to flares at 12 months following TNFi tapering in a JIA population in stable clinical remission.

Methods: We included 56 JIA patients in stable remission undergoing TNFi therapy tapered at baseline and in some cases at 6 months. Read More

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March 2019
2 Reads

The impact of transducer frequency in ultrasound evaluation of subclinical skin involvement in limited cutaneous systemic sclerosis patients.

Clin Exp Rheumatol 2019 Feb 25. Epub 2019 Feb 25.

Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy.

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February 2019

Safety of the use of anti-IL17A treatment in a patient with certolizumab-induced sarcoidosis.

Clin Exp Rheumatol 2019 Mar-Apr;37(2):344-345. Epub 2019 Mar 7.

Department of Rheumatology, Hôpital Nord Franche-Comté, Trevenans, France.

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March 2019
11 Reads

Investigation of candidate gene copy number identifies FCGR3B as a potential biomarker for rheumatoid arthritis.

Clin Exp Rheumatol 2019 Mar 7. Epub 2019 Mar 7.

GenHotel, Univ Evry, Université Paris-Saclay, Evry, France.

Objectives: Copy number variants (CNVs) could explain a part of the missing heritability in rheumatoid arthritis (RA). Our goal is to investigate the association of RA with CNVs of three functional candidate genes, Glutathione S-transferase M1 (GSTM1), Glutathione S-transferase T1 (GSTT1) and Fcγ receptor type IIIAB (FCGR3B).

Methods: We quantified the absolute copy number of GSTM1, GSTT1 and FCGR3B genes using droplet digital PCR. Read More

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March 2019
1 Read

Effectiveness and safety of anti-tumour necrosis factor therapy with certolizumab pegol observed in real-life rheumatoid arthritis patients in Germany: results from the non-interventional FαsT study.

Clin Exp Rheumatol 2019 Mar 7. Epub 2019 Mar 7.

Department of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Campus Kerckhoff Bad Nauheim, Germany.

Objectives: To report the tolerability and effectiveness of certolizumab pegol (CZP) for the treatment of patients with active rheumatoid arthritis (RA) in a routine clinical practice setting.

Methods: FαsT (NCT01069419) was a non-interventional, observational 104-week (wk) study performed at 163 sites in Germany. RA patients were treated according to the treating physician's discretion. Read More

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March 2019
4 Reads

Differential expression of miR-17-92 cluster among varying histological stages of minor salivary gland in patients with primary Sjögren's syndrome.

Clin Exp Rheumatol 2019 Mar 7. Epub 2019 Mar 7.

The First College of Clinical Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Objectives: To investigate the differential expression of miR-17-92 cluster, which encodes 6 microRNAs (miRNAs) including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a, among varying histological stages of labial minor salivary gland (MSG) tissues in patients with primary Sjögren's syndrome (pSS).

Methods: Fifty-seven pSS patients and 13 healthy volunteers were enrolled in this study. The pSS patients were allocated to 3 subgroups of advanced clinical stages according to the histological findings of the MSG biopsies. Read More

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March 2019
2 Reads

Ba-Duan-Jin alleviates pain and fibromyalgia-related symptoms in patients with fibromyalgia: results of a randomised controlled trial.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Objectives: Fibromyalgia is a chronic debilitating pain syndrome. There has been growing interest in the development of non-pharmacological therapies. Ba-Duan-Jin is an ancient Chinese exercise for health promotion, yet easy to learn. Read More

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February 2019
3 Reads
2.724 Impact Factor

Innate lymphoid cells are increased in systemic lupus erythematosus.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

The First Affiliated Hospital of Zhengzhou University, Henan, China.

Objectives: Innate lymphoid cells (ILCs) are emerging mediators of immunity and accumulation of inflammatory ILC populations can occur in inflammatory-mediated conditions. We aimed to examine the proportion of different subgroups of ILCs in the peripheral blood of patients with systemic lupus erythematosus (SLE) to evaluate the pathogenesis of SLE.

Methods: Peripheral blood mononuclear cells were collected from 51 SLE patients and 26 healthy controls. Read More

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February 2019
5 Reads

Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, USA.

Objectives: Systemic lupus erythematous (SLE) is a heterogeneous disease lacking highly effective treatment options. Here we tested if targeting both BAFF and ICOSL has superior efficacy than single target inhibition in the mouse arthritis and lupus models. We also generated AMG 570, an ICOSL and BAFF bispecific inhibitory molecule, for potential treatment of autoimmune diseases such as SLE. Read More

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February 2019
2 Reads

Hyperlipoprotein(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project.

Clin Exp Rheumatol 2019 02 15. Epub 2019 Feb 15.

Epidemiology, Genetics & Atherosclerosis Res. Group on Systemic Inflammatory Diseases, Rheumatology Div., Hosp. Univ. Marqués de Valdecilla, IDIVAL, Univ. of Cantabria, Santander, Spain, and Univ. of the Witwatersrand, Johannesburg, South Africa.

Objectives: Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Read More

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February 2019
5 Reads

Serum soluble Fas and Fas ligand (FasL) in primary Sjögren's syndrome.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, The Queen Elizabeth Hospital, Woodville, and Discipline of Medicine, University of Adelaide, Australia.

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February 2019
2 Reads

Long-term outcomes of patients with primary angiitis of the central nervous system.

Clin Exp Rheumatol 2019 Feb 18. Epub 2019 Feb 18.

Department of Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, USA.

Objectives: Primary angiitis of the central nervous system (PACNS) is a vasculitis confined to the brain and spinal cord, which often presents with severe cognitive and functional deficits. Despite progress in diagnosis, little is still known about long-term outcomes. Our aim was to evaluate long-term functional capabilities, quality of life, and depression, and to determine the effect of treatment duration on patient outcomes. Read More

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February 2019
1 Read

Novel biomarkers containing citrullinated peptides for diagnosis of systemic lupus erythematosus using protein microarrays.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Wu Lien-Teh Institute, Harbin Medical University, Harbin, China.

Objectives: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by autoantibody production. This study aims to identify biomarkers involving citrullinated peptides that can be used for SLE diagnosis.

Methods: After a negative selection step with serum from healthy controls (HCs), a phage library of 12 peptides was used for three rounds of screening with sera from 30 SLE patients. Read More

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February 2019
1 Read
2.724 Impact Factor

Change in cardiovascular risk after initiation of anti-rheumatic treatment in early rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Amsterdam Rheumatology and immunology Center/Reade, and Amsterdam Rheumatology and Immunology Center/VU University Medical Center, Amsterdam, the Netherlands.

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February 2019
1 Read

The mortality rate and causes of death among juvenile idiopathic arthritis patients in Finland.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Children and Adolescents, Oulu University Hospital; Medical Research Centre, University of Oulu and Oulu University Hospital; and PEDEGO Research Unit, University of Oulu, Finland.

Objectives: To explore mortality rates and causes of death in juvenile idiopathic arthritis (JIA) patients in Finland compared with the general population.

Methods: All incident patients with JIA (age <16 years at the index day) during 2000-2014 were collected from the nationwide register maintained by the Social Insurance Institution of Finland and The National Population Registry identified three age-, sex- and residence-matched controls for each case. They were followed up together until 31st Dec 2015. Read More

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February 2019
2 Reads

Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Objectives: Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns. Radiographic progression is not associated with the current disease activity biomarkers. We investigated a matrix metalloproteinase mediated metabolite of C-reactive protein (CRPM) and two biomarkers of citrullinated vimentin (VICM and anti-MCV) as novel biomarkers of disease activity. Read More

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February 2019
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Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

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February 2019
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Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: To investigate ex-vivo drug-inhibited cytokine production before the start of a biological DMARD (bDMARD) as predictor of treatment response in rheumatoid arthritis (RA).

Methods: In a prospective RA cohort study [BIO-TOP], blood samples were obtained from patients before the start of a bDMARD (abatacept, adalimumab, etanercept, rituximab or tocilizumab). Peripheral blood mononuclear cells were pre-incubated for 1 hour with the therapeutic in-vivo concentration of the bDMARD and stimulated for 24 hours with heat-killed Candida albicans or Pam3Cys. Read More

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February 2019
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Clinical features of systemic sclerosis patients with anti-RNA polymerase III antibody in a single centre in Spain.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Unit of Systemic Autoimmune Diseases, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

Objectives: To evaluate the clinical features and survival of patients with positive anti-RNA polymerase III (anti-RNAP III) in a Spanish single centre.

Methods: We analysed 221 patients with SSc according to LeRoy and Medsger criteria. Twenty-six patients with positivity for anti-RNAP III antibodies were compared with 195 negative patients. Read More

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February 2019
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Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis.

Clin Exp Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

UCL Centre for Nephrology, Royal Free Hospital, London, UK.

Objectives: We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital.

Methods: Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK.

Results: The incidence of anti-MPO positivity in patients without AAV was 39. Read More

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February 2019
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