Search our Database of Scientific Publications and Authors

I’m looking for a

    7388 results match your criteria Clinical and experimental rheumatology[Journal]

    1 OF 148

    Efficacy of intensive hand physical therapy in patients with systemic sclerosis.
    Clin Exp Rheumatol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Rheumatology and Immunology of Medical Centre, University of Pécs, Hungary.
    Objectives: To evaluate the efficacy of a three-week period of complex and intensive hand physical therapy on hand function in patients with systemic sclerosis (SSc).

    Methods: Thirty-one patients with SSc were treated. Hand stretching exercises, ergotherapy supplemented with thermal and mud baths, whirlpool therapy and soft tissue massage were daily used during a three-week period. Read More

    Autologous stem cell transplantation in systemic sclerosis: a systematic review.
    Clin Exp Rheumatol 2017 Aug 30. Epub 2017 Aug 30.
    The Department of Rheumatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
    Objectives: Haematopoetic autologous stem cell transplantation (ASCT) has emerged as a treatment option for patients with refractory, severe autoimmune disease. This is a systematic review of the current literature on ASCT in adult patients with systemic sclerosis (SSc).

    Methods: Original articles published between 2005 and 2016 that evaluated the use of ASCT in patients with SSc were reviewed with respect to the primary outcomes of overall and transplant related mortality (TRM) rates, and secondary outcomes of changes in modified Rodnan Skin Score (mRSS), forced vital capacity (FVC), progression/event free survival (P/EFS) and quality of life measures. Read More

    A novel iloprost administration method with portable syringe pump for the treatment of acral ulcers and Raynaud's phenomenon in systemic sclerosis patients. A pilot study (ILOPORTA).
    Clin Exp Rheumatol 2017 Aug 31. Epub 2017 Aug 31.
    Clinica Medica, Department of Internal Medicine, Ospedali Riuniti University Hospital, Ancona; and Department of Clinical and Molecular Sciences, Section of Clinical Medicine, Università Politecnica delle Marche, School of Medicine, Ancona, Italy.
    Objectives: The objective of the study is to evaluate the feasibility, safety and efficacy of home infusion of iloprost with the new portable syringe pump Infonde®, for the treatment of scleroderma-related Raynaud's phenomenon and digital ulcers.

    Methods: 12 scleroderma patients were treated with iloprost at home, using the pump, with infusion cycles of 2 days per month (24 hours a day), for 6 months.

    Results: The home treatment proved feasible since ten patients (83%) completed the entire infusion cycle, thus satisfying the feasibility target imposed by the protocol (75%). Read More

    Expression of TREM-2 and its inhibitory effects on TNF-α induced inflammation in fibroblast-like synoviocytes via inhibiting p38 pathway activation.
    Clin Exp Rheumatol 2017 Aug 31. Epub 2017 Aug 31.
    Department of Orthopaedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou; Department of Orthopaedics, Zengcheng District People's Hospital, Guangzhou, China.
    Objectives: It is not clear whether TREM-2 (the "triggering receptor expressed on myeloid cells 2") is expressed in fibroblast-like synovial cells (FLSs). In this study, we aimed to determine the expression of TREM-2 in rheumatoid arthritis (RA)-FLSs and explore whether and how TREM-2 modulates the function of RA-FLSs.

    Methods: Western blot and RT-PCR were used to detect the expression of TREM-2 in RA-FLSs, siRNA and lentivirus were used to down-regulate and up-regulate the expression of TREM-2 in RA-FLSs. Read More

    Severe oesophageal disease and its associations with systemic sclerosis.
    Clin Exp Rheumatol 2017 Aug 30. Epub 2017 Aug 30.
    Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
    Objectives: Severe oesophageal disease in patients with systemic sclerosis (SSc), referred as scleroderma oesophagus, is characterised by ineffective or absent peristalsis along with hypotensive oesophagogastric junction (hEGJ). The associations between scleroderma oesophagus and different clinical and laboratory manifestations of SSc is still controversial. In this study we aimed to assess associations between scleroderma oesophagus, diagnosed by high resolution manometry (HRM), and other manifestations of disease. Read More

    The presence of small joint contractures is a risk factor for survival in 439 patients with systemic sclerosis.
    Clin Exp Rheumatol 2017 Aug 31. Epub 2017 Aug 31.
    Department of Rheumatology and Immunology, University of Pécs, Hungary.
    Objectives: Analysis of risk factors and mortality of 439 patients with systemic sclerosis (SSc) in a tertiary care centre.

    Methods: The mean follow up time was 8.4±5. Read More

    Liver safety of non-tumour necrosis factor inhibitors in rheumatic patients with past hepatitis B virus infection: an observational, controlled, long-term study.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Greece.
    Objectives: The risk of hepatitis B virus (HBV) reactivation with non-tumour necrosis factor inhibitor (non-TNFi) biologic agents in patients with rheumatic diseases and past HBV infection has not been definively elucidated. We assessed the comparative safety of non-TNFi and TNFi biologic agents in such patients in real-life clinical settings.

    Metgods: We carried out a retrospective cohort study from the Department of Rheumatology, University Hospital of Heraklion. Read More

    Evaluation of non-contrast MRI biomarkers in lupus nephritis.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Arthritis Res. Ctr. Epidemiology, Musculoskeletal Res. & Dermatological Sciences, Academic Health Science Ctr., Univ.of Manchester; and The Kellgren Ctr. for Rheumatology, NIHR Manchester Musculoskeletal Biomed. Res. Ctr., Central Manchester Univ., UK.
    Objectives: To investigate the association of novel non-contrast MRI biomarkers with standard measurements of renal function and renal disease activity in lupus.

    Methods: A pilot study of lupus nephritis (LN) and lupus non-nephritis (LNN) patients, and healthy volunteers (HV), was undertaken. Multi-modal renal MRI was performed including sequences for arterial spin labelling (ASL) measuring blood flow, diffusion tensor imaging (DTI), measuring microstructural disruption, and effective transverse relaxation time (T2*) which is a biomarker of micro-haemorrhage. Read More

    MiR-338-5p suppresses rheumatoid arthritis synovial fibroblasts proliferation and invasion by targeting ADAMTS-9.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Rheumatology, the Second Affiliated Hospital, Harbin Medical University, Heilongjiang, China.
    Objectives: We proposed to find out the role of miR-338-5p played in cell proliferation and invasion of rheumatoid arthritis synovial fibroblasts (RASFs) by regulating ADAMTS-9.

    Methods: QRT-PCR was performed to quantify the miR-338-5p and ADAMTS-9 mRNA expression in RA sample tissues and normal synovial tissues. Western blot was performed to evaluate the ADAMTS-9 protein levels in transfected RASFs. Read More

    Interleukin-35 inhibits angiogenesis through STAT1 signalling in rheumatoid synoviocytes.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shenyang, China.
    Objectives: We studied the anti-angiogenic effect of interleukin-35 (IL-35) by investigating its effects on signal transmission through the Janus kinase signal transducer and activator of transcription (JAK-STAT) pathway in fibroblast-like synoviocytes (FLS).

    Methods: Using the collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA), we derived and cultured FLS, stimulated FLS with IL-35 at different concentrations and examined the expression levels of mRNA and protein of both vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), endostatin, TNF-α, and IL-6 using reverse transcription polymerase chain reaction (RT-PCR) and immunoblotting. We used Western blotting to study the effects of IL-35 on the function of the JAK-STAT pathway in FLS. Read More

    Improved adalimumab dose decision with comprehensive diagnostics data.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    BioTeZ Berlin-Buch GmbH, Berlin, Germany.
    Objectives: Monoclonal antibodies are important in the treatment of rheumatoid arthritis (RA). This is the first trial to monitor the effect of adalimumab dose escalation in persistently active RA. The aim of this study was to identify the response to adalimumab to improve the basis for making decision in relation to actual drug capacity in serum. Read More

    Cilostazol inhibits the expression of hnRNP A2/B1 and cytokines in human dermal microvascular endothelial cells.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital, Catholic Kwandong University, College of Medicine, Incheon, Korea.
    Objectives: hnRNP A2/B1 has been identified as a target antigen of anti-endothelial cell IgA antibody in patients with Behçet's disease (BD). In addition, increased expression of cellular hnRNP A2/B1 is stimulated by Streptococcus sanguinis or the sera from patients with BD. We aimed to investigate the effects of cilostazol on the expression of hnRNP A2/B1 and chemokines in human dermal microvascular endothelial cells (HDMECs). Read More

    Involvement of pentraxin-3 in anti-neutrophil cytoplasmic antibody production induced by aluminum salt adjuvant.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan.
    Objectives: Pentraxin 3 (PTX3) is a multifunctional soluble factor. PTX3 can be involved in the regulation of vasculitis and is expressed in the cytoplasm of neutrophils. As anti-neutrophil cytoplasmic antibody (ANCA) is recognised as a cause of vasculitis, we aimed to discover the role of PTX3 in ANCA production in vivo. Read More

    Cardiovascular risk stratification in axial spondyloarthritis: carotid ultrasound is more sensitive than coronary artery calcification score to detect high-cardiovascular risk axial spondyloarthritis patients.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
    Objectives: To determine the ability of Coronary Artery Calcification Score (CACS) and carotid ultrasonography (US) to detect high cardiovascular (CV) risk axial spondyloarthritis (ax-SpA) patients.

    Methods: CACS and carotid plaques were assessed in 66 consecutive ax-SpA patients (51 fulfilling criteria for ankylosing spondylitis and 15 for non-radiological ax-SpA) without history of CV events. The Systematic Coronary Risk Evaluation (SCORE) calculated using total cholesterol (TC-SCORE) was assessed in 64 patients without diabetes mellitus or chronic kidney disease. Read More

    Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.
    Objective: Biologics for rheumatoid arthritis (RA) patients with moderate to severe disease may preserve joint function. Matrix metalloproteinase 3 (MMP-3), a key tissue degrading protease, is highly elevated in RA. MMP-3, which measures the total pool of circulating MMP-3 species (cMMP3), is a commonly measured biomarker in rheumatology. Read More

    An exploratory study to determine whether infliximab modifies levels of rheumatoid factor and antibodies to cyclic citrullinated peptides in rheumatoid arthritis patients.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
    Objectives: The aim of this study was to investigate the relationship between serum infliximab (IFX) levels and changes of RF and ACPA levels in patients with rheumatoid arthritis (RA).

    Methods: Enzyme-linked immunosorbent assays (ELISA) [Promonitor® IFX R1 (version 2) (Progenika Biopharma, Spain)] were used to measure drug levels and antidrug-antibodies (ADAb) in IFX RA-treated patients (n=19). Disease activity was assessed using DAS28. Read More

    Lipopolysaccharide-binding protein is a sensitive disease activity biomarker for rheumatoid arthritis.
    Clin Exp Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Rheumatology and Immunology, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing, China.
    Objectives: This study was performed to evaluate the performance and clinical significance of lipopolysaccharide-binding protein (LBP) as a disease activity biomarker in rheumatoid arthritis (RA).

    Methods: LBP levels were measured by enzyme-linked immunosorbent assay (ELISA). The associations between LBP and the clinical and serological features of RA and its clinical significance as a RA disease activity biomarker were analysed. Read More

    Two-year retention rate of golimumab in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: data from the LORHEN registry.
    Clin Exp Rheumatol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Rheumatology, Gaetano Pini Institute, Milan, Italy.
    Objectives: We aimed to provide data on golimumab real-life use in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) from a multicentre observational registry of Northern Italy.

    Methods: We extracted data of patients who started treatment with golimumab from October 2010, and who had at least one follow-up visit. Data were analysed until a maximum follow-up of 24 months. Read More

    Chinese lupus treatment and research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations.
    Clin Exp Rheumatol 2017 Jul 7. Epub 2017 Jul 7.
    Department of Rheumatology, Peking Union Medical College Hospital, and Peking Union Medical College & Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
    Objectives: This study aimed to examine the associations between family history and clinical manifestations and immunologic characteristics of lupus in China.

    Methods: Based on their family history, lupus patients from the Chinese lupus treatment and research group (CSTAR) registry were categorised: familial lupus (FL), family history of other rheumatic disorders (RD), and sporadic lupus (SL). Demographic data, clinical manifestations, and laboratory data were compared among these three groups. Read More

    Olfactory dysfunction and autoimmunity: pathogenesis and new insights.
    Clin Exp Rheumatol 2017 Jul 7. Epub 2017 Jul 7.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to the Sackler Faculty of Medicine Tel-Aviv University, Tel-Aviv, Israel.
    Olfaction plays an important role in the perception of our environment. Smell impairment is known to be a manifestation of several autoimmune diseases. Similarities between the olfactory and immune systems and previously published human studies and animal models of autoimmune diseases account for the accumulating evidence for this observation. Read More

    Timing of onset affects arthritis presentation pattern in antisyntethase syndrome.
    Clin Exp Rheumatol 2017 Jul 26. Epub 2017 Jul 26.
    Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy.
    Objectives: To evaluate if the timing of appearance with respect to disease onset may influence the arthritis presentation pattern in antisynthetase syndrome (ASSD).

    Methods: The patients were selected from a retrospective large international cohort of ASSD patients regularly followed-up in centres referring to AENEAS collaborative group. Patients were eligible if they had an antisynthetase antibody testing positive in at least two determinations along with arthritis occurring either at ASSD onset (Group 1) or during the course of the disease (Group 2). Read More

    The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic.
    Clin Exp Rheumatol 2017 Jul 6. Epub 2017 Jul 6.
    Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center; Sackler Faculty of Medicine, Tel-Aviv University; and Incumbent of the Laura Schwarz-KipChair for Research of Autoimmune Diseases, Tel-Aviv University, Israel.
    Objectives: The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies.

    Methods: We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB. Read More

    Pro-fibrotic effect of IL-6 via aortic adventitial fibroblasts indicates IL-6 as a treatment target in Takayasu arteritis.
    Clin Exp Rheumatol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Objectives: This study aimed to clarify potential mechanism of IL-6 involved in adventitial fibrosis via adventitial fibroblast in Takayasu arteritis (TAK).

    Methods: Immunohistochemistry and double-labelled immunofluorescence were performed on vascular tissue from patients with TAK and controls. Human aorta adventitial fibroblast (AAF) was cultured and stimulated with interleukine 6 (IL-6)/IL-6 receptor (IL-6R). Read More

    Are the cutaneous manifestations in patients with primary antiphospholipid syndrome a marker for predicting lung manifestations?
    Clin Exp Rheumatol 2017 Jul 17. Epub 2017 Jul 17.
    School of Medicine, University of Belgrade, and Internal medicine, "Bezanijska Kosa", University Medical Center, Belgrade, Serbia.
    Objectives: The aim of this study was to investigate association between pulmonary and skin manifestations in a large group of patients with primary antiphospholipid syndrome (PAPS) as well as their connection with antiphospholipid antibodies.

    Methods: Our prospective study comprises of 390 patients with primary APS. Antiphospholipid antibody (aPL) analysis included detection of aCL (IgG/IgM), ß2GPI (IgG/IgM) and LA. Read More

    Undifferentiated connective tissue disease: predictors of evolution into definite disease.
    Clin Exp Rheumatol 2017 Aug 2. Epub 2017 Aug 2.
    Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain.
    Objectives: The natural evolution of undifferentiated connective tissue diseases (UCTD) has not yet been established. The aim of our study was to analyse the clinical outcomes of a cohort of UCTD patients followed in a routine outpatient setting and to establish which clinical, serological or capillaroscopy features are associated with an increased risk of evolution to definite connective tissue disease (CTD).

    Methods: Data for this study were collected by a retrospective review of 758 patients referred to our hospital, between 1999 and 2008, with suspected CTD. Read More

    Serum levels of IgG antibodies against alpha-enolase are increased in patients with Behçet's disease and are associated with the severity of oral ulcer, erythrocyte sedimentation rates, and C-reactive protein.
    Clin Exp Rheumatol 2017 Jul 6. Epub 2017 Jul 6.
    Dept. of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Medical Research Centre; and Division of Rheumatology, Dept. of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
    Objectives: Behçet's disease (BD) is a chronic inflammatory disease of unknown etiology, characterised by recurrent oral and genital ulcers, skin lesions, uveitis, and arthritis. It is regarded as vasculitis and anti-endothelial cell antibodies (AECA) are found in patients with BD. One of the endothelial cell antibodies was reported to recognise alpha-enolase. Read More

    Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases.
    Clin Exp Rheumatol 2017 Jul 27. Epub 2017 Jul 27.
    Zabludowitz Centre for Autoimmune Diseases, Sheba Medical Centre, Tel Hashomer; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel.
    Objectives: Autoantibodies to the dense fine speckled 70 (DFS70) antigen are common among antinuclear antibodies (ANA) positive healthy individuals (HI). We assessed the prevalence of anti-DFS70 antibodies in patients with and without ANA-associated rheumatic diseases (AARDs) by two methods: chemiluminescent immunoassay (CIA) and an indirect immunofluorescence (IIF) assay based on immunoadsorption for DFS70.

    Methods: Fifty-one ANA-positive sera samples from patients with confirmed clinical diagnosis of AARD, 92 samples from HI and 85 samples submitted to a reference laboratory for routine ANA testing were evaluated for the presence of anti-DFS70 antibodies. Read More

    One year in review 2017: systemic lupus erythematosus.
    Clin Exp Rheumatol 2017 Jul-Aug;35(4):551-561. Epub 2017 Jul 11.
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
    Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately affects women. It is characterised by a broad spectrum of clinical manifestations, however, its course and organ involvement are unpredictable. Although over the last few decades an improvement in survival for SLE patients has been observed, pathogenic mechanisms underlying this disease are still unclear. Read More

    Immunogenicity and safety of the inactivated hepatitis A vaccine in children with juvenile idiopathic arthritis on methotrexate treatment: a matched case-control study.
    Clin Exp Rheumatol 2017 Jul-Aug;35(4):711-715. Epub 2017 Jul 13.
    Second Department of Paediatrics, P. & A. Kyriakou Children's Hospital, University of Athens, Greece.
    Objectives: To describe the immunogenicity and side effects of immunisation against hepatitis A virus (HAV) in JIA patients on methotrexate treatment, who have not been previously exposed to HAV.

    Methods: Case-control study performed in JIA patients and healthy controls matched on age and gender. The subjects received two doses of inactivated anti-HAV vaccine (720 mIU/ml) intramuscularly at 0 and 6 months. Read More

    Psychosomatic syndromes in fibromyalgia.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):106-111. Epub 2017 Jun 29.
    Department of Psychology, University of Turin, Italy.
    Objectives: The aim of this study was to compare the prevalence of psychosomatic symptoms in patients with fibromyalgia (FM) or rheumatoid arthritis (RA).

    Methods: Seventy-six consecutive women with FM and 80 with RA without concomitant FM were assessed using the Diagnostic Criteria for Psychosomatic Research (DCPR) interview to evaluate the presence of psychosomatic syndromes. Beck Depression Inventory - II (BDI-II) and Form Y of the State-Trait Anxiety Inventory (STAI-Y) were administered in order to assess the symptoms of anxiety and depression. Read More

    Motor cortex tRNS improves pain, affective and cognitive impairment in patients with fibromyalgia: preliminary results of a randomised sham-controlled trial.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):100-105. Epub 2017 Jun 29.
    Department of Experimental Biomedicine and Clinical Neuroscience (BioNec), Neurology Section, University of Palermo, Italy.
    Objectives: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients. Read More

    Earthquake vulnerability of fibromyalgia patients: six-month follow-up after the catastrophic disasters in central Italy.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):93-99. Epub 2017 Jun 29.
    Rheumatology Unit, ASST-Fatebenefratelli- L. Sacco University Hospital, Milan, Italy.
    Objectives: To investigate the 6-month impact of the catastrophic earthquakes that struck central Italy in August and October 2016 on the health-related quality of life (HRQoL) of patients with fibromyalgia (FM).

    Methods: We compared a cohort of 55 consecutive FM patients who had been exposed to an earthquake with a control group of 49 FM patients who had not been exposed to it. At each time-point (baseline, and after one, two, four and six months), the patients completed self-reported electronic versions of the revised Fibromyalgia Impact Questionnaire (FIQR) and the Fibromyalgia Activity Score (FAS) on a web platform. Read More

    Childhood adversities in patients with fibromyalgia: are they related to comorbid lifetime major depression?
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):112-118. Epub 2017 Jun 29.
    Clinical Neurosciences, Villa S.Benedetto Menni, Hermanas Hospitalarias, Como, Italy; Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Univ. of Maastricht, Netherland; and Psychiatry & Behavioral Sciences, Univ.of Miami, USA.
    Objectives: Fibromyalgia (FM) is a syndrome of unknown aetiology that is frequently associated with depressive disorders, and childhood adversities (including maltreatment and parental loss) are frequently described in subjects with FM and depression. The aim of this study was to investigate the extent to which the high percentage of childhood adversities reported by patients with FM is related to FM itself or to a comorbid lifetime depressive disorder.

    Methods: Ninety-four consecutive FM patients were assessed for lifetime major depression using the DSM-IVSCID-CV interview. Read More

    One year in review 2017: fibromyalgia.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):6-12. Epub 2017 Jun 28.
    Rheumatology Unit, ASST-Fatebenefratelli-L. Sacco University Hospital, Milan, Italy.
    Fibromyalgia (FM) is a complex syndrome characterised by chronic pain, fatigue and functional symptoms. Widespread pain is often its most typical feature, whereas other manifestations may be associated to various extents. Its aetiopathogenesis is still a matter of debate, but various pharmacological and non-pharmacological therapies are currently available for its treatment. Read More

    Development of responder criteria for multicomponent non-pharmacological treatment in fibromyalgia.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):86-92. Epub 2017 Jun 29.
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands.
    Objectives: There is a need to identify individual treatment success in patients with fibromyalgia (FM) who received non-pharmacological treatment. The present study described responder criteria for multicomponent non-pharmacological treatment in FM, and estimated and compared their sensitivity and specificity.

    Methods: Candidate responder sets were 1) identified in literature; and 2) formulated by expert group consensus. Read More

    Acute and chronic pain in orthopaedic and rheumatologic diseases: mechanisms and characteristics.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):127-131. Epub 2017 Jun 29.
    IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
    Pain is one of the most frequent clinical symptoms encountered by orthopaedic surgeons and rheumatologists as it is one of the main reasons for patients seeking medical help. Traumas and/or inflammatory rheumatologic diseases give rise to two different types of acute pain, but their chronic evolution is so similar that they both need to be treated as early as possible. It is now widely accepted that chronic pain is a disease per se, and that its location may be less important than the way in which it is perceived by people suffering from it. Read More

    Current trends in disability claims due to fibromyalgia syndrome.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):119-126. Epub 2017 Jun 29.
    Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy.
    Fibromyalgia syndrome (FMS) affects 0.4-8% of the general population predominantly in the female population with a F:M ratio of 3-9:1. It is characterised by persistent widespread pain and other associated clinical conditions such as chronic fatigue, irritable bowel syndrome (IBS), temporomandibular joint dysfunction (TMJD), sleep disorders and cognitive impairment. Read More

    Influence of autonomic nervous system dysfunction in the genesis of sleep disorders in fibromyalgia patients.
    Clin Exp Rheumatol 2017 May-Jun;35 Suppl 105(3):74-80. Epub 2017 Jun 29.
    Rheumatology Unit, ASST-Fatebenefratelli-L. Sacco University Hospital, Milan, Italy.
    Objectives: Fibromyalgia (FM) is characterised by chronic musculoskeletal pain, autonomic nervous system (ANS) dysfunction, and disturbed sleep. The aim of this study was to evaluate the influence of ANS dysfunction on the genesis of sleep disorders.

    Methods: Fifty female FM patients and 45 healthy subjects matched for age, gender and body mass index underwent a clinical, polysomnographic and autonomic profile evaluation at rest and during a tilt test in order to determine muscle sympathetic nerve activity (MSNA), plasma catecholamine levels, and the spectral indices of cardiac sympathetic (LFRR) and vagal (HFRR) modulation computed by means of the spectrum analysis of RR during sleep. Read More

    The use of hand perfusion scintigraphy to assess Raynaud's phenomenon associated with hand-arm vibration syndrome.
    Clin Exp Rheumatol 2017 Jun 30. Epub 2017 Jun 30.
    Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
    Objectives: This study aimed to evaluate the hand perfusion scintigraphic features of hand-arm vibration syndrome (HAVS) and to compare these with the features of primary and secondary Raynaud's phenomenon (RP) associated with systemic sclerosis (SSc).

    Methods: Hand perfusion scintigraphy was performed in 57 patients with primary RP, 71 patients with HAVS-related RP, and 15 patients with SSc-related RP. We calculated 6 ratios: chilled to ambient hand and wrist ratios of the first peak height, initial slope, and blood pool uptake. Read More

    Prevalence and significance of anti-saccharomyces cerevisiae antibodies in primary Sjögren's syndrome.
    Clin Exp Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
    Objectives: Saccharomyces cerevisiae is a common yeast used in the food industry. IgG and IgA antibodies against the phosphopeptidomannan of the S. cerevisiae cell wall (ASCA) are a well known marker of disease severity in Crohn's disease. Read More

    Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS™).
    Clin Exp Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Cleveland Clinic, Cleveland, Ohio, USA.
    Objectives: Nintedanib is a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis (IPF). The pathological pathways involved in fibrogenesis in IPF and interstitial lung disease associated with systemic sclerosis (SSc-ILD) show commonalities; both involve fibroblast activation, myofibroblast accumulation and deposition of extracellular matrix. The SENSCIS™ trial is a randomised, placebo-controlled Phase III trial that will evaluate the efficacy and safety of nintedanib in patients with SSc-ILD (NCT02597933). Read More

    Clinical determinants of elevated systolic pulmonary artery pressure measured by transthoracic Doppler echocardiography in early systemic sclerosis.
    Clin Exp Rheumatol 2017 Jun 20. Epub 2017 Jun 20.
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Florence, Italy.
    Objectives: To explore the prevalence and clinical associations of elevated systolic pulmonary artery pressure (sPAP), measured by Transthoracic Doppler-echocardiography (TTE) in patients with early systemic sclerosis (SSc).

    Methods: A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research (EUSTAR) database was performed. SSc patients with <3 years from the first non-Raynaud's phenomenon (RP) symptom at baseline EUSTAR visit, were selected. Read More

    Opioid use in patients with polymyalgia rheumatica.
    Clin Exp Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Division of Rheumatology; and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
    Objectives: To examine the trends of chronic opioid use in patients with polymyalgia rheumatica (PMR) over an 11-year period in Olmsted County, Minnesota, USA and compare use to subjects without the disease.

    Methods: Retrospective data on opioid prescriptions were collected from 2005 to 2015 in a population-based incidence cohort of patients meeting the 2012 American College of Rheumatology classification criteria for PMR alongside comparison subjects. Poisson regression methods were used to compare opioid use between these groups. Read More

    Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis.
    Clin Exp Rheumatol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Orthopaedics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
    Objectives: Osteoarthritis (OA) is a common degenerative disease of the synovial joints. Although numerous studies have been performed, the aetiology of OA remains unclear. Evidence suggests that DNA methylation plays important roles in OA. Read More

    One year in review 2017: pathogenesis of rheumatoid arthritis.
    Clin Exp Rheumatol 2017 May-Jun;35(3):368-378. Epub 2017 Jun 7.
    Immuno-Allergology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
    Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic and environmental factors. It has been postulated that a high-risk genetic background, in combination with epigenetic marks and environmental exposures, leads to a cascade of events inducing synovitis and consequent destructive arthritis. The clinical picture of joint involvement in RA is the result of chronic inflammation of the synovium, characterised by interactions of resident cells such as fibroblast-like synoviocytes (FLS) with cells of the innate (e. Read More

    1 OF 148