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    10238 results match your criteria Clinical and experimental dermatology[Journal]

    1 OF 205

    Cutaneous manifestations of phosphate solution extravasation.
    Clin Exp Dermatol 2017 Oct 30. Epub 2017 Oct 30.
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
    Extravasation injuries are common in patients receiving multiple intravenous infusions. Although such injuries are closely associated with the infusion of cytotoxic chemotherapy, they have also been been associated with extravasation of noncytotoxic drugs. Extravasation injuries can lead to skin ulceration and nerve and tendon damage, and therefore to permanent disability. Read More

    Antioxidant status of serum bilirubin, uric acid and albumin in pemphigus vulgaris.
    Clin Exp Dermatol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
    Background: Oxidative stress and low antioxidant status are implicated in the pathogenesis of inflammatory and autoimmune diseases. Pemphigus vulgaris (PV) is an extremely severe autoimmune bullous dermatosis characterized by intraepithelial bullae on the skin and mucosa, and its antioxidant status is not fully understood.

    Aim: To assess correlations between PV and serum antioxidant levels of bilirubin, uric acid (UA) and albumin. Read More

    In chronic spontaneous urticaria, high numbers of dermal endothelial cells, but not mast cells, are linked to recurrent angio-oedema.
    Clin Exp Dermatol 2017 Oct 24. Epub 2017 Oct 24.
    Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Chronic spontaneous urticaria (CSU) is an inflammatory skin disorder characterized by recurrent weals, angio-oedema or both. Recent studies have shown that the number of endothelial cells is increased in the skin of patients with CSU, but the underlying mechanisms and clinical implications of this are unclear.

    Aim: To evaluate whether mast cell (MC) or endothelial cell (EC) numbers correlate with CSU and whether they are relevant for disease duration, disease activity or the presence of clinical features. Read More

    Invasive squamous cell carcinoma: comparison of differentiation grade and tumour depth by anatomical site in 1666 tumours.
    Clin Exp Dermatol 2017 Oct 24. Epub 2017 Oct 24.
    Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
    Background: Invasive squamous cell carcinomas (SCCs) presents with different grades of differentiation and depths of invasion.

    Aim: To compare the grade of differentiation, tumour diameter and tumour depth by anatomical site in invasive SCC.

    Methods: Retrospective clinical and histopathological data on consecutive cases of SCC came from a clinic in Sydney, Australia were assessed. Read More

    Itching for nail fashion: chronic urticaria and chronic hand dermatitis secondary to acrylate and methacrylate allergy in gel nail varnish.
    Clin Exp Dermatol 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
    Allergic contact dermatitis (ACD) secondary to acrylates and methacrylates is a well- described occurrence, particularly in those who wear or handle gel nail varnish. Management involves avoidance of the identified allergen. The cause of chronic urticaria (CI) is often not identified, and CU is not known to be associated with acrylates or methacrylates. Read More

    Cutaneous atypical papular CD8+ lymphoproliferative disorder at acral sites in a renal transplant patient.
    Clin Exp Dermatol 2017 Dec 20;42(8):902-905. Epub 2017 Oct 20.
    Kempf und Pfaltz, Histological Diagnostics, Zürich, Switzerland.
    A 20-year-old woman presented with a 2-month history of an acute symmetrical eruption, manifesting as asymptomatic ill-defined erythematous macules and hyperkeratotic papules on the palms. The patient was a renal transplant recipient, and the lesions had developed 2 months post-transplantation. Histologically, the eruption shared features of a reactive inflammatory condition called papular eruption of atypical CD8+ lymphocytes as well as primary cutaneous acral CD8+ T-cell lymphoma (a provisional indolent entity in the new World Health Organisation classification of lymphoid neoplasms, 2016). Read More

    Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.
    Clin Exp Dermatol 2017 Dec 15;42(8):874-880. Epub 2017 Oct 15.
    Georgia Dermatopathology Associates, Atlanta, GA, USA.
    Background: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM.

    Methods: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex and occupation, who were all from the endemic area, and tested these using direct immunofluorescence (DIF), confocal microscopy, immunohistochemistry and immunoblotting (IB).

    Results: Of the 30 patients with El Bagre-EPF, 27 had autoantibodies to APM that colocalized with commercial antibodies to myocardium-enriched zonula occludens-1-associated protein (MYZAP), desmoplakin (DP)1 and DP2, plakophilin 4, and Armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) (P < 0. Read More

    Melanoma arising from a plaque-type blue naevus with subcutaneous cellular nodules of the scalp.
    Clin Exp Dermatol 2017 Oct 15. Epub 2017 Oct 15.
    Section of Dermatology, Department of Medical, Surgical and Neurosciences, University of Siena, Siena, Italy.
    Plaque-type blue naevus (PTBN) is a very rare variant of blue naevus (BN). The potential malignancy of subcutaneous cellular nodules (SCN) in PTBN was discovered in 2012, and there is currently no clear consensus on prognostic factors or management guidelines of such lesions. PTBN on the scalp have not been described in the literature. Read More

    Generalized pustular psoriasis triggered by Zika virus infection.
    Clin Exp Dermatol 2017 Oct 13. Epub 2017 Oct 13.
    Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia.
    Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Read More

    First-line treatment in lymphomatoid papulosis: a retrospective multicentre study.
    Clin Exp Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Dermatology, Hospital Clínico, University of Barcelona, IDIBAPS, Barcelona, Spain.
    Background: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce.

    Aim: To assess the daily clinical practice approach to LyP and the response to first-line treatments.

    Methods: This was a retrospective study enrolling 252 patients with LyP. Read More

    Efficacy of perilesional and intralesional triamcinolone acetonide injections in pemphigus vulgaris lesions of the scalp: an effective therapeutic option.
    Clin Exp Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    The scalp is a common location for pemphigus vulgaris (PV), and scalp lesions may be resistant to standard treatment. Perilesional/intralesional triamcinolone acetonide (TA) injections have been used successfully to treat oropharyngeal and ocular involvement in PV. Data on the efficacy of perilesional and intralesional triamcinolone acetonide injections in scalp lesions in PV are lacking. Read More

    Self-reported minor infections in patients with hidradenitis suppurativa and healthy controls.
    Clin Exp Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    Department of Dermatology, University Hospital Zealand, Roskilde, Denmark.
    Background: Patients with hidradenitis suppurativa (HS) often report opportunistic infections such as herpes and urinary tract infections.

    Aim: To compare opportunistic infections in patients with HS against a group of healthy controls (HCs).

    Methods: In total, 99 patients with HS and 109 HCs were recruited at random to this retrospective case-control study. Read More

    Brooke-Spiegler syndrome: focus on reflectance confocal microscopy findings of trichoepithelioma and flat cylindroma.
    Clin Exp Dermatol 2017 Dec 4;42(8):906-909. Epub 2017 Oct 4.
    Department of Dermatology, Turkiye Cumhuriyeti Saglik Bakanligi Okmeydani Egitim ve Arastirma Hastanesi, Istanbul, Turkey.
    Brooke-Spiegler syndrome (BSS) is a rare, autosomal dominant disorder characterized by multiple adnexal tumours, especially trichoepitheliomas, cylindromas and occasionally spiradenomas. These lesions usually begin to appear in the second or third decade of life. Malignant transformation of pre-existing tumours may occur. Read More

    Acral melanoma foot lesions. Part 1: epidemiology, aetiology, and molecular pathology.
    Clin Exp Dermatol 2017 Dec 22;42(8):845-848. Epub 2017 Sep 22.
    Department of Dermatology, State University of New York Downstate Medical Center, Department of Dermatology, Brooklyn, NY, USA.
    Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma (MM) found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of MM found in patients of African or East Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. The pathogenesis of AM is unclear, but genetic alterations, including mutations in BRAF, NRAS, and KIT have been implicated. Read More

    Improvement of wound healing by regulated oxygen-enriched negative pressure-assisted wound therapy in a rabbit model.
    Clin Exp Dermatol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Burns and Plastic Surgery, Deyang People's Hospital, Deyang, China.
    Background: Development of drug therapies and other techniques for wound care have resulted in significant improvement of the cure rate and shortening of the healing time for wounds. A modified technique of regulated oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) has been reported.

    Aim: To evaluate the efficacy and impact of RO-NPT on wound recovery and inflammation. Read More

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