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    10415 results match your criteria Clinical and experimental dermatology[Journal]

    1 OF 209

    Immunohistochemical and molecular analysis of spitzoid neoplasms with pulverocyte subclones.
    Clin Exp Dermatol 2018 May 20. Epub 2018 May 20.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
    Background: Clonal naevi are characterized by a focal proliferation of pigmented melanocytes in an otherwise banal naevus. These subclones are often composed of aggregates of larger, epithelioid melanocytes with nuclear atypia and dusty-grey cytoplasmic pigmentation, which are referred to as 'pulverocytes', and this finding may lead to a misdiagnosis of malignant melanoma (MM).

    Aim: To characterize the significance of subclones of dusty-grey pigmented epithelioid melanocytes within spitzoid neoplasms. Read More

    Cutaneous sarcoidosis: a new subset in the spectrum of paraneoplastic dermatoses.
    Clin Exp Dermatol 2018 May 20. Epub 2018 May 20.
    Department of Dermatology, Al-Azhar University for Girls, Cairo, Egypt.
    Background: Sarcoidosis is a well-described disease that can be associated with various malignancies; however, this correlation is still not fully clarified.

    Aim: To determine the clinical and histological features, demographic characteristics, and prognosis of patients diagnosed with paraneoplastic sarcoidosis (PS).

    Methods: This observational cohort prospective study included all patients diagnosed as cutaneous sarcoidosis. Read More

    Intravenous immunoglobulins in dermatology. Part 2: clinical indications and outcomes.
    Clin Exp Dermatol 2018 May 17. Epub 2018 May 17.
    Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.
    Intravenous immunoglobulin (IVIg) is a solution of human IgG, salt, sugars and solvents used to treat a multitude of diseases. Although IVIg has been known to treat many diseases safely and successfully, there are relatively few supporting randomized controlled trials. In part two of this review, we assess the clinical indications of IVIg in dermatological disorders and the outcomes of its use. Read More

    Intravenous immunoglobulins in dermatology. Part 1: biological mechanisms and methods of administration.
    Clin Exp Dermatol 2018 May 17. Epub 2018 May 17.
    Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas NHS Foundation Trust, Great Maze Pond, London, UK.
    Intravenous immunoglobulin (IVIg) is a solution of human IgG, salt, sugars and solvents, which is used to treat a multitude of diseases. Although IVIg has been known to treat many diseases safely and successfully, there are relatively few supporting randomized controlled trials. In this article, we review the biological mechanisms of IVIg in dermatological disorders and the practicalities of its use, including its mechanism of action, dosing, availability, costs and adverse effects. Read More


    Toll-like receptor signalling induces the expression of serum amyloid A in epidermal keratinocytes and dermal fibroblasts.
    Clin Exp Dermatol 2018 May 16. Epub 2018 May 16.
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
    Background: Toll-like receptors (TLRs) play critical roles in innate immune response by sensing pathogen- or damage-associated molecular patterns. Epidermal keratinocytes and dermal fibroblasts also produce proinflammatory cytokines and chemokines under stimulation with TLR ligands. Serum amyloid A (SAA) is an essential factor in the pathogenesis of secondary amyloidosis, and also has immunomodulatory functions. Read More

    Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage.
    Clin Exp Dermatol 2018 May 16. Epub 2018 May 16.
    Department of Clinical Laboratory and Pathology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia.
    Background: We have previously reported that about 30% of patients affected by a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia (termed El Bagre-EPF or pemphigus Abreu-Manu) have systemic compromise. In the current study, we focused on studying autoreactivity to the kidney and its pathological correlations.

    Aim: To investigate patients with El Bagre-EPF for renal compromise. Read More

    Dermatological aspects of tularaemia: a study of 168 cases.
    Clin Exp Dermatol 2018 May 14. Epub 2018 May 14.
    Department of Infectious Diseases, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
    Background: Tularaemia is a zoonotic infectious disease caused by Francisella tularensis, an aerobic, uncapsulated, gram-negative coccobacillus. Several case reports have appeared on the dermatological manifestations of tularaemia, but relatively few longer-term studies are available.

    Aim: To identify skin features of tularaemia that aid in its diagnosis. Read More

    Localized genital bullous pemphigoid.
    Clin Exp Dermatol 2018 May 14. Epub 2018 May 14.
    Department of Dermatology, University College Hospitals, London, UK.
    Genital bullous pemphigoid (GBP) is a rare localized subset of bullous pemphigoid (BP). BP is characterized by autoantibodies against hemidesmosomes, which are involved in the structural integrity of the epidermis, and this results in subepidermal blistering. Typically, GBP affects women and children. Read More

    Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma.
    Clin Exp Dermatol 2018 May 13. Epub 2018 May 13.
    Department of Dermatology, Hospital Universitario de Salamanca, Paseo de San Vicente, Salamanca, Spain.
    Background: Cutaneous squamous cell carcinoma (cSCC) represents the most common form of skin cancer after basal cell carcinoma, and can be both locally invasive and metastatic to distant sites. Growth rate (GR) has been poorly evaluated in cSCC, despite clinical evidence suggesting that GR is an important risk factor in cSCC.

    Aim: To analyse the influence of GR in cSCC prognosis. Read More

    Association between serum interleukin-17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis.
    Clin Exp Dermatol 2018 May 10. Epub 2018 May 10.
    Pfizer Inflammation and Immunology Research Unit, Cambridge, MA, USA.
    Background: Psoriasis is a systemic inflammatory disease with a pathophysiology involving interleukin (IL)-17. Tofacitinib is an oral Janus kinase inhibitor. Etanercept is a tumour necrosis factor-α inhibitor used in the treatment of psoriasis. Read More

    Cartilage hair hypoplasia with cutaneous lymphomatoid granulomatosis.
    Clin Exp Dermatol 2018 May 10. Epub 2018 May 10.
    Department of Pathology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
    Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Read More

    Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent.
    Clin Exp Dermatol 2018 May 9. Epub 2018 May 9.
    Department of Applied Chemistry, Hanyang University, Ansan-si, Korea.
    Sugar is a well-known cosmetic ingredient for moisturizing skin with minimal side-effects. Several reports have demonstrated an antimelanogenic effect of sugar in melanocytes. We evaluated the whitening efficacy of galacturonic acid (GA), the main component of pectin, as an anti-melanogenic agent. Read More

    Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis.
    Clin Exp Dermatol 2018 May 8. Epub 2018 May 8.
    Department of Food Science and Technology, Hoseo University, Asan, Chungnam, Korea.
    Background: Artemisia scoparia Waldst. et Kitaib (AS) (Oriental wormwood, known as Bissuk in Korea) is a plant used in cosmetic and pharmaceutical treatments. However, the effect of AS on atopic dermatitis (AD) has not been described. Read More

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