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    10170 results match your criteria Clinical and experimental dermatology[Journal]

    1 OF 204

    Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin.
    Clin Exp Dermatol 2017 Sep 20. Epub 2017 Sep 20.
    Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.
    The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Read More

    Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients.
    Clin Exp Dermatol 2017 Sep 19. Epub 2017 Sep 19.
    Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia.
    Intraepidermal carcinoma (IEC) is a type of in situ squamous cell carcinoma (SCC), although progression of IEC is rare. We sought to investigate differences between the actinic skin changes preceding the development of both SCC and IEC. Photographs of 63 skin sites at which either SCC or IEC subsequently developed in 37 renal transplant recipients (RTRs) were examined for features of actinic change. Read More

    Increased levels of mitochondrial DNA copy number in patients with vitiligo.
    Clin Exp Dermatol 2017 Oct 3;42(7):749-754. Epub 2017 Sep 3.
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Oxidative stress is known to be involved in the pathogenesis of autoimmune diseases such as vitiligo. Evidence suggests that the human mitochondrial DNA copy number (mtDNAcn) is vulnerable to damage mediated by oxidative stress. The purpose of this study was to examine and compare peripheral blood mtDNAcn and oxidative DNA damage byproducts (8-hydroxy-2-deoxyguanosine; 8-OHdG) in patients with vitiligo and healthy controls (HCs). Read More

    Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacial granulomatosis.
    Clin Exp Dermatol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Clinical-Surgical, Diagnostic and Pediatric Science, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
    Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non-necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32-year-old man with a 2-year history of oedema and swelling of the upper lip without systemic symptoms. Read More

    Influence of narrowband ultraviolet B phototherapy on serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients with psoriasis.
    Clin Exp Dermatol 2017 Oct 27;42(7):786-790. Epub 2017 Jul 27.
    Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
    Psoriasis is characterized by keratinocyte resistance to apoptosis. We recently demonstrated an increase in serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients after topical treatment for psoriasis. We decided to verify whether narrowband ultraviolet B (NB-UVB) has a similar effect. Read More

    Follicular porokeratosis: four new cases.
    Clin Exp Dermatol 2017 Jul 27. Epub 2017 Jul 27.
    Department of Cellular Pathology, Warwick Hospital, Warwick, Warwickshire, UK.
    Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer). Read More

    Lichen planopilaris in a Latin American (Chilean) population: demographics, clinical profile and treatment experience.
    Clin Exp Dermatol 2017 Oct 27;42(7):755-759. Epub 2017 Jul 27.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, USA.
    Background: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated.

    Aim: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. Read More

    Plasmacytoid dendritic cells and type I interferon in the immunological response against warts.
    Clin Exp Dermatol 2017 Jul 24. Epub 2017 Jul 24.
    Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.
    Background: Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus (HPV)-induced skin lesions has not been well studied.

    Aim: To investigate pDC occurrence and activity in HPV-induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis (EDV)-associated lesions. Read More

    Serial D-dimer plasma levels in a patient with chronic spontaneous urticaria developing resistance to omalizumab.
    Clin Exp Dermatol 2017 Aug 10;42(6):667-669. Epub 2017 Jul 10.
    Allergy Department, Clinica San Carlo, Paderno Dugnano (MI), Milan, Italy.
    Chronic spontaneous urticaria (CSU) is a condition presenting as the spontaneous occurrence of itchy weals with or without angio-oedema for > 6 weeks. A patient with severe chronic spontaneous urticaria who developed resistance to omalizumab is described. The patient's D-dimer plasma levels strictly paralleled the disease activity despite the administration of anti-IgE therapy. Read More

    Comprehensive profiling of H-Ras signalling in angiosarcoma endothelium.
    Clin Exp Dermatol 2017 Aug 10;42(6):645-647. Epub 2017 Jul 10.
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
    The MS1/SVR system, in which MS1 represents immortalized endothelial cells and SVR represents MS1 cells transformed with oncogenic human-rat sarcoma protein (H-Ras), has been used for around 20 years as a valuable tool to study angiogenesis and carcinogenesis. Despite the use of these cells in numerous studies, a comprehensive profile of the signalling differences due to oncogenic H-Ras transformation has not been performed previously. In this study, we profiled the well-known MS1 and SVR cell lines using a combination of both Western blot and gene chip assays. Read More

    Therapeutic experience with oral finasteride for androgenetic alopecia in female-to-male transgender patients.
    Clin Exp Dermatol 2017 Oct 10;42(7):743-748. Epub 2017 Jul 10.
    Dermatology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
    Background: Androgenic treatment of female-to-male transgender patients may result in androgenetic alopecia (AGA). Use of 5-alpha-reductase inhibitors are useful as oral treatment of AA in men. There are no previous studies of the use of finasteride in transgender men as treatment of AGA. Read More

    Systemic lupus erythematosus, following prodromal idiopathic thrombocytopenic purpura, presenting with skin lesions resembling malignant atrophic papulosis.
    Clin Exp Dermatol 2017 Oct 10;42(7):774-776. Epub 2017 Jul 10.
    Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
    Systemic lupus erythematosus (SLE) is an autoimmune disease. Its incidence in the UK is approximately 1 per 10 000. Cutaneous involvement, encompassing acute, subacute and chronic disease, occurs in over two-thirds of cases, and can often be the first clue to diagnosis. Read More

    Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management.
    Clin Exp Dermatol 2017 Aug 29;42(6):601-606. Epub 2017 Jun 29.
    Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
    Tattooing, which involves the placement of ink into the skin, is an ancient decorative technique that has remained popular in modern society. Tattoos have long been known to cause cutaneous reactions, which include the emergence of neoplasms such as keratoacanthoma (KA) and squamous cell carcinoma (SCC) in tattooed areas of the skin. We review the clinical presentations, histology and treatment options for squamous neoplasms, primarily KA and SCC, arising in tattoos. Read More

    Therapeutic efficacy and safety of oral tranexamic acid and that of tranexamic acid local infiltration with microinjections in patients with melasma: a comparative study.
    Clin Exp Dermatol 2017 Oct 25;42(7):728-734. Epub 2017 Jun 25.
    Department of Dermatology, Venereology and Leprosy, Dr RP Govt Medical College, Kangra (Tanda), India.
    Background: Tranexamic acid (TXA) has been used orally, intravenously, topically and intradermally (microinjection, microneedling) for treating melasma. However, the comparative efficacy of these different routes of administration remains underevaluated.

    Aim: To ascertain the comparative efficacy of different routes of administration of TXA. Read More

    Long-term management of chronic spontaneous urticaria with omalizumab.
    Clin Exp Dermatol 2017 Oct 25;42(7):735-742. Epub 2017 Jun 25.
    Dermatology Department, Coimbra University Hospital Centre, Coimbra, Portugal.
    Background: Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking.

    Aim: To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens.

    Methods: This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines. Read More

    Adjuvant therapy with low-dose interferon-beta for stage II and III melanoma: results of a retrospective analysis.
    Clin Exp Dermatol 2017 Oct 25;42(7):781-785. Epub 2017 Jun 25.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Interferon (IFN)-alfa as an adjuvant therapy has been found to improve relapse-free survival in patients with malignant melanoma (MM). However, the efficacy of IFN-beta has not been studied in detail. This study evaluated the contribution of adjuvant IFN-beta therapy to improvements in the prognosis of patients with MM. Read More

    Expression of the autoantigen TRIM33/TIF1γ in skin and muscle of patients with dermatomyositis is upregulated, together with markers of cellular stress.
    Clin Exp Dermatol 2017 Aug 22;42(6):659-662. Epub 2017 Jun 22.
    Department of Dermatology and Allergy, University Hospital, Bonn, Germany.
    Dermatomyositis (DM) is an autoimmune disorder associated with a dysregulation of immune homeostasis of both the innate and adaptive immune system. Earlier data suggested that these two arms of the immune system interconnect in DM. In the current study, we analysed the association of autoantigen expression [adaptive system components: Mi2, transcriptional intermediary factor (TIF)1γ, small ubiquitin-like modifier 1 activating enzyme subunit (SAE)1, melanoma differentiation-associated protein (MDA)5] with markers of cellular stress (innate system components: MxA, p53) in skin and muscle (immunohistology and gene expression data, respectively). Read More

    Rosacea in black South Africans with skin phototypes V and VI.
    Clin Exp Dermatol 2017 Aug 22;42(6):670-673. Epub 2017 Jun 22.
    Dermatology Department, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Rosacea is a chronic facial dermatosis considered to affect primarily white patients with light phototype skin, and is poorly documented in black patients. The aim of this study was to document the clinical features of rosacea in patients with phototypes V and VI. An 8-year retrospective chart review of patients with a clinical and histological diagnosis of rosacea or acne rosacea was undertaken. Read More

    Vesiculobullous variant of erythema elevatum diutinum.
    Clin Exp Dermatol 2017 Oct 22;42(7):777-780. Epub 2017 Jun 22.
    Unidad de Gestión Clínica Dermatología y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain.
    The vesiculobullous variant of erythema elevatum diutinum (EED) is a very rare variant of EED. We describe a 16-year-old boy who presented with symmetrical nodular lesions accompanied by vesicles on the dorsa of his hands. Biopsy findings were consistent with EED. Read More

    First case of anaphylaxis after botulinum toxin type A injection.
    Clin Exp Dermatol 2017 Oct 21;42(7):760-762. Epub 2017 Jun 21.
    Bright and Clear Dermatology Clinic, Seoul, Korea.
    Botulinum toxin type A (BTA) (also known as onabotulinum toxin A) injection is widely used in the field of cosmetic dermatology. Although a few adverse events related to intramuscular BTA injection have been reported, no life-threatening adverse reaction has been documented to date. We report a case of anaphylaxis induced by intramuscular BTA injection into the masseter muscles of a 35-year-old woman. Read More

    Lichenoid keratosis is frequently misdiagnosed as basal cell carcinoma.
    Clin Exp Dermatol 2017 Aug 21;42(6):663-666. Epub 2017 Jun 21.
    Department of Dermatology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia.
    Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis. Read More

    Validation and comparison of quality-of-life measures for topical 5-fluorouracil treatment: results from a randomized controlled trial.
    Clin Exp Dermatol 2017 Jul;42(5):488-495
    Center for Dermatoepidemiology, VA Medical Center, Providence, RI, USA.
    Background: Topical 5-fluorouracil (5-FU) is commonly used for high-risk patients with keratinocyte carcinoma (KC). Skindex and Skin Cancer Index (SCI) are validated instruments to measure quality of life (QoL) of patients with KC and those who have had surgical treatment of KCs.

    Aim: To validate Skindex and SCI for topical 5-fluorouracil (5-FU) application and to compare the two QoL instruments. Read More

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