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    10323 results match your criteria Clinical and experimental dermatology[Journal]

    1 OF 207

    Dermoscopy of basal cell carcinoma.
    Clin Exp Dermatol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    Dermoscopy is widely used in dermatological practice. The method increases the accuracy of basal cell carcinoma (BCC) detection. Pigmented and nonpigmented variants of basal cell carcinoma present different dermoscopic features. Read More

    Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis.
    Clin Exp Dermatol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
    Background: Psoriasis is a chronic, autoimmune, inflammatory skin disorder. 25-hydroxy vitamin D [25(OH)D] deficiency may contribute to the pathogenesis of psoriasis through reduction in antiproliferative, anti-inflammatory and antiangiogenic activities.

    Aim: To evaluate the relationship between circulating 25(OH)D levels and psoriasis, and to determine the correlation between serum/plasma 25(OH)D levels and psoriasis severity. Read More

    Acrodermatitis acidaemica.
    Clin Exp Dermatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Dermatology, St George's Healthcare NHS Trust, London, UK.
    Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Read More

    Increased sensitivity and high specificity of indirect immunofluorescence in detecting IgG subclasses for diagnosis of bullous pemphigoid.
    Clin Exp Dermatol 2018 Jan 14. Epub 2018 Jan 14.
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
    Background: Indirect immunofluorescence (IIF) microscopy on monkey oesophagus is an important assay for the diagnosis of bullous pemphigoid (BP). Its relatively low sensitivity (60-80%) may be partly due to insufficient detection of minor IgG subclasses.

    Aim: To determine the operating characteristics of an IgG subclass in IIF. Read More

    Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis.
    Clin Exp Dermatol 2018 Jan 14. Epub 2018 Jan 14.
    Department of Diagnostic Radiology, Assiut University Hospital, Assiut, Egypt.
    Background: Psoriasin (S100A7) and koebnerisin (S100A15) are proinflammatory proteins upregulated in psoriasis, but their relation to atherosclerosis remains unclear.

    Aim: To evaluate the role of serum psoriasin and koebnerisin as possible markers for subclinical atherosclerosis in patients with psoriasis.

    Methods: Serum levels of psoriasin and koebnerisin were measured by ELISA in 45 patients with psoriasis and in 45 healthy controls (HCs). Read More

    Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting.
    Clin Exp Dermatol 2018 Jan 14. Epub 2018 Jan 14.
    East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Background: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes. Sebaceous neoplasms (SNs) may occur before other malignancies, and may lead to the diagnosis, which allows testing of other family members, cancer surveillance, risk-reducing surgery or prevention therapies.

    Aim: To evaluate the efficacy of universal immunohistochemistry (IHC) screening of SNs in a service setting. Read More

    The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease.
    Clin Exp Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals, Leeds, UK.

    Factors influencing skin cancer excision rates in Scottish primary care.
    Clin Exp Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Dermatology, Royal Infirmary of Edinburgh, Edinburgh, UK.
    Skin cancer incidence rates are rising in the UK, yet many areas are experiencing a shortage of dermatologists. We sought to compare skin cancer excision rates between general practice (GP) surgeons to identify factors associated with good practice, through a retrospective analysis of GP skin cancer histopathology reports in three Scottish Health Boards over a 4-year period. Postal questionnaires were used to explore factors affecting surgeons' excision rates. Read More

    Sézary syndrome managed with histone deacetylase inhibitor followed by anti-CCR4 monoclonal antibody.
    Clin Exp Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
    A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis. Read More

    Overweight and obesity may play a role in the pathogenesis of chronic spontaneous urticaria.
    Clin Exp Dermatol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
    Background: Chronic spontaneous urticaria (CSU) is one of the commonest diseases in allergological and dermatological practice. It constitutes an interdisciplinary problem, and its pathogenesis is not always easily determined. It has been suggested that metabolic syndrome and hyperlipidaemia are more frequent in patients with CSU, but the influence of overweight and obesity on the development of CSU has not been thoroughly investigated. Read More

    Modification of the Fitzpatrick system of skin phototype classification for the Indian population, and its correlation with narrowband diffuse reflectance spectrophotometry.
    Clin Exp Dermatol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
    Background: The Fitzpatrick classification for skin phototyping is widely used, but its usefulness in dark-skinned populations has been questioned by some researchers. Recently, skin colour measurement has been proposed for phototyping skin colour objectively.

    Aims: To modify the Fitzpatrick system of skin phototyping for the Indian population and to study its correlation with skin colour using narrowband diffuse reflectance spectrophotometry METHODS: Answer choices for three items (eye colour, hair colour, colour of unexposed skin) out of 10 in the original Fitzpatrick questionnaire were modified, followed by self-administration of the original and the modified Fitzpatrick questionnaire by 70 healthy Indian volunteers. Read More

    Depression- and anxiety-like behaviour is related to BDNF/TrkB signalling in a mouse model of psoriasis.
    Clin Exp Dermatol 2018 Jan 8. Epub 2018 Jan 8.
    Department ofDermatology, Medical School of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi Province, China.
    Background: The prevalence of anxiety and depression is significantly higher in individuals with psoriasis than in the general population. Clinical data also show that anti-anxiety and antidepression drugs can reduce skin lesions in patients with psoriasis, but the actual mechanism is still poorly understood.

    Aim: To investigate whether brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrKB) signalling plays a role in the mechanism underlying psoriasis with depression and anxiety behaviours. Read More

    What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology.
    Clin Exp Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
    This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published during 2015, and focuses on the epidemiology and methodology issues of AE. For systematic reviews on the prevention and treatment of AE, see Part 2 of this update. Read More

    An observational study of the efficacy of azithromycin in erythema annulare centrifugum.
    Clin Exp Dermatol 2018 Jan 3. Epub 2018 Jan 3.
    Department of Dermatology, Hindu Rao Hospital, New Delhi, India.
    Erythema annulare centrifugum (EAC) is a form of figurate erythema consequent to a cutaneous hypersensitivity reaction to an underlying agent. In the present study, we aimed to assess the role of oral azithromycin in cases of idiopathic EAC. We performed an open trial of azithromycin in 10 patients with idiopathic EAC. Read More

    Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.
    Clin Exp Dermatol 2017 Dec 28. Epub 2017 Dec 28.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 TRead More

    Heparin-induced haemorrhagic bullous dermatosis.
    Clin Exp Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO, USA.
    Background: Heparin-induced haemorrhagic bullous dermatosis (HBD) is a rare but probably underdiagnosed reaction to heparin, with 26 cases reported in the English literature. Currently, there is no consensus regarding the treatment.

    Aim: To assess our new cases of HBD and review the previously reported cases, in order to draw conclusions about this adverse skin reaction to heparin. Read More

    Subcutaneous immunoglobulin for the treatment of deep morphoea in a child.
    Clin Exp Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Dermatology, Instituto Nacional Pediatría, Mexico City, Mexico.
    Morphoea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis and/or subcutaneous tissues. Intravenous IgG therapy has induced improvement in some fibrotic conditions. The primary indication for subcutaneous IgG (SCIG) is in primary immunodeficiency disorders as replacement therapy; however, recently there has been considerable interest in SCIG as an immunomodulatory agent. Read More

    A protective role for FADD dominant negative (FADD-DN) mutant in trinitrochlorobenzene (TNCB)-induced murine contact hypersensitivity reactions.
    Clin Exp Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
    Background: Fas-associated protein with death domain (FADD) is a classic adaptor protein in apoptosis. Increasing evidence has shown that FADD is also implicated in T-cell development, activation and proliferation. The role of FADD in inflammatory disorders remains largely unexplored. Read More

    Legionella feeleii: an unusual organism associated with cutaneous infection in an immunocompromised patient.
    Clin Exp Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Dermatology Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
    We report a 23-year-old immunocompromised woman who, following cardiac transplantation, presented with an unusual cutaneous eruption. She developed a widespread pustular rash, systemic symptoms and a high temperature with raised inflammatory markers. The diagnosis was reached when a skin biopsy was cultured onto Legionella agar (buffered charcoal yeast extract) and Legionella feeleii was isolated. Read More

    Morphoea profunda and its relationship to eosinophilic fasciitis.
    Clin Exp Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Royal United Hospital Bath, Bath, Avon, UK.
    In this small case series, all eight patients were women in their fifth and sixth decades. This is similar to the female predominance in morphoea and less in keeping with eosinophilic fasciitis (EF). All cases had diffuse induration of their limbs with both proximal and distal patterns of distribution, and five of the patients exhibited peau d'orange skin. Read More

    Recessive epidermolytic ichthyosis results from loss of keratin 10 expression, regardless of the mutation location.
    Clin Exp Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
    Epidermolytic ichthyosis (EI) is a rare skin disorder caused by mutations in the genes KRT1 and KRT10, and is usually inherited in an autosomal dominant fashion. Only five recessive mutations causing EI have been described, all of which are located in the central region of the KRT10 gene. In the current study, we aimed to identify the genetic defect underlying EI in a 12-year-old patient. Read More

    Dermoscopic features of pseudoxanthoma elasticum.
    Clin Exp Dermatol 2017 Dec 22. Epub 2017 Dec 22.
    Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Pseudoxanthoma elasticum (PXE) is a disease characterized by aberrant mineralization of soft tissue and fragmentation of elastic fibres. It is often difficult to distinguish PXE clinically from pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-like PDE). However, we have identified that the dermoscopic findings in PXE include coalescing and reticulated yellow-white clods on a light purple-red background, whereas the dermoscopic findings in PXE-like PDE lack such a coloured background. Read More

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