354 results match your criteria Clinical and Translational Gastroenterology [Journal]


Home Blenderized Tube Feeding: A Practical Guide for Clinical Practice.

Authors:
Caroline Weeks

Clin Transl Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Blank Children's Hospital Pediatric Gastroenterology Clinic, Des Moines, Iowa, USA.

Although commercial enteral formulas have been available on the market for several decades, a cultural shift toward consuming unprocessed foods with minimally added sugar has sparked interest in the preparation of home blenderized tube feedings for enteral feeding-dependent patients. Recent surveys, however, indicate lack of clinical awareness or familiarity in the management of this method of nutrition support. This article aims to equip the gastroenterologist with a guide for initiation, monitoring, and evaluation of a blenderized tube feedings regimen, and provides insights into an opportunity for greater partnership between the gastrointestinal provider and registered dietitian. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000001DOI Listing
February 2019
3 Reads

Plasma MicroRNA Signature Validation for Early Detection of Colorectal Cancer.

Clin Transl Gastroenterol 2019 Jan;10(1):e00003

Advanced Marker Discovery (Amadix), Valladolid, Spain.

Objectives: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000003DOI Listing
January 2019

Common NOD2 Risk Variants as Major Susceptibility Factors for Bacterial Infections in Compensated Cirrhosis.

Clin Transl Gastroenterol 2019 Jan;10(1):e00002

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Objectives: Common nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants have been associated with bacterial infections (BIs) in cirrhosis, in particular, spontaneous bacterial peritonitis, and mortality. Our aim was to evaluate the independent association of NOD2 variants with BI according to the decompensation stage.

Methods: Consecutive patients with cirrhosis in 2 academic medical centers were included and genotyped for the NOD2 variants p. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000002DOI Listing
January 2019
1 Read

Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival.

Clin Transl Gastroenterol 2019 Jan;10(1):e00004

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China.

Objectives: Molecular prognostic biomarkers for gastric cancer (GC) are still limited. We aimed to identify potential messenger RNAs (mRNAs) associated with GC prognosis and further establish an mRNA signature to predict the survival of GC based on the publicly accessible databases.

Methods: Discovery of potential mRNAs associated with GC survival was undertaken for 441 patients with GC based on the Cancer Genome Atlas (TCGA), with information on clinical characteristics and vital status. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000004DOI Listing
January 2019

A Multicenter, Randomized, Controlled Trial of Rebamipide Plus Lansoprazole for the Treatment of Postendoscopic Submucosal Dissection Ulcers.

Clin Transl Gastroenterol 2019 Jan;10(1):e00008

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

Objectives: To evaluate the healing efficacy of rebamipide and lansoprazole combination therapy with lansoprazole alone for endoscopic submucosal dissection (ESD)-induced ulcers and clarify the ulcer healing-associated factors.

Methods: Three hundred patients were randomized into control and experimental groups after they underwent ESD. The patients received intravenous pantoprazole (30 mg) every 12 hours and oral rebamipide (100 mg, experimental group) or placebo (control group) 3 times daily on days 1-3. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000008DOI Listing
January 2019

Splanchnic Vein Thrombosis in Cirrhosis - Areas Still in the Shadow.

Clin Transl Gastroenterol 2018 Dec 7;9(12):211. Epub 2018 Dec 7.

Department of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, "St. Spiridon" University Hospital, Gastroenterology and Hepatology Institute, 16 Universității St, 700115, Iași, Romania.

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http://dx.doi.org/10.1038/s41424-018-0079-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283861PMC
December 2018
2 Reads

Topical Analgesia with Lidocaine Plus Diclofenac Decreases Pain in Benign Anorectal Surgery: Randomized, Double-blind, and Controlled Clinical Trial.

Clin Transl Gastroenterol 2018 Nov 23;9(11):210. Epub 2018 Nov 23.

Drug Development Services, Pharmacy and Pharmaceutical Technology and Physical Chemistry Department, University of Barcelona, Barcelona, Spain.

Objective: The aim of this study is to evaluate the efficacy and safety of a topical formulation containing lidocaine plus diclofenac (CLIFE1) compared to lidocaine (CLIFE2), to decrease pain in benign anorectal surgery (BARS) to date not evaluated. More than 50% of patients undergoing BARS, especially hemorrhoidectomy, suffer from moderate and severe postoperative pain. This remains an unresolved problem that could be addressed with the new CLIFE1 topical treatment. Read More

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http://dx.doi.org/10.1038/s41424-018-0075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250696PMC
November 2018
11 Reads

Correction: The Use of International Classification of Diseases Codes to Identify Patients with Pancreatitis: A Systematic Review and Meta-analysis of Diagnostic Accuracy Studies.

Clin Transl Gastroenterol 2018 Nov 21;9(11):209. Epub 2018 Nov 21.

Department of Surgery, University of Auckland, Auckland, New Zealand.

The original version of this Article presented incorrect information for citation 50. This has now been corrected in both the PDF and HTML versions of the Article. Petrov, M. Read More

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http://dx.doi.org/10.1038/s41424-018-0078-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249208PMC
November 2018
10 Reads

Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia.

Clin Transl Gastroenterol 2018 Nov 19;9(11):208. Epub 2018 Nov 19.

Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, University of Leuven, Leuven, Belgium.

Objectives: Achalasia is a primary esophageal motility disorder resulting from selective loss of inhibitory neurons in the esophageal myenteric plexus, likely due to an autoimmune response with involvement of the adaptive immune system. Innate immune processes of the host constitute the bridge between environmental etiological factors and the adaptive immune system. Although these remain poorly investigated, they might be of diagnostic and therapeutic relevance. Read More

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http://www.nature.com/articles/s41424-018-0076-6
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http://dx.doi.org/10.1038/s41424-018-0076-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240577PMC
November 2018
9 Reads

Probiotics can Cause D-Lactic Acidosis and Brain Fogginess: Reply to Quigley et al.

Clin Transl Gastroenterol 2018 Nov 19;9(11):207. Epub 2018 Nov 19.

Division of Neurogastroenterology/Motility, Department of Medicine, Augusta University Medical Center, Augusta, GA, USA.

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http://dx.doi.org/10.1038/s41424-018-0077-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240559PMC
November 2018
2 Reads

Correction: Immune Checkpoint Inhibitor-Associated Colitis and Hepatitis.

Clin Transl Gastroenterol 2018 Nov 14;9(11):206. Epub 2018 Nov 14.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

The original version of this Article contained an error in the spelling of colitis in the article title. It was incorrectly spelt as "colits". This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://www.nature.com/articles/s41424-018-0072-x
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http://dx.doi.org/10.1038/s41424-018-0072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235959PMC
November 2018
19 Reads

Correction: A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.

Clin Transl Gastroenterol 2018 Nov 14;9(11):205. Epub 2018 Nov 14.

Center for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.

This Article was originally published under Nature Research's License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly. Read More

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http://www.nature.com/articles/s41424-018-0073-9
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http://dx.doi.org/10.1038/s41424-018-0073-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235902PMC
November 2018
12 Reads

SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis.

Clin Transl Gastroenterol 2018 Nov 12;9(11):204. Epub 2018 Nov 12.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and clinical outcomes, as well as their potential interactions with environmental risk factors, remain unclear. These issues are addressed here in a large Chinese CP cohort. Read More

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http://dx.doi.org/10.1038/s41424-018-0069-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232107PMC
November 2018
15 Reads

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.

Clin Transl Gastroenterol 2018 Nov 13;9(11):203. Epub 2018 Nov 13.

The Second Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Background: Numerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC.

Methods: Studies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors. Read More

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http://www.nature.com/articles/s41424-018-0070-z
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http://dx.doi.org/10.1038/s41424-018-0070-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232177PMC
November 2018
12 Reads

Genotype Matters in Patients with Acute-on-chronic Liver Failure Due to Reactivation of Chronic Hepatitis B.

Clin Transl Gastroenterol 2018 Nov 12;9(11):202. Epub 2018 Nov 12.

Department of Gastroenterology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China, 650101.

Background: Acute-on-chronic liver failure (ACLF) can be caused by reactivation of chronic hepatitis B virus (HBV) infection (HBV-ACLF). It's unclear whether HBV genotypes affect the clinical and therapeutical outcomes of patients with HBV-ACLF. This study was to investigate the short-term antiviral response and overall survival in HBV-ACLF patients treated by tenofovir or entecavir. Read More

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http://dx.doi.org/10.1038/s41424-018-0071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230554PMC
November 2018
10 Reads

Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study.

Clin Transl Gastroenterol 2018 Nov 2;9(10):201. Epub 2018 Nov 2.

Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

Objective: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disease caused by mutations in the forkhead box protein 3 gene (FOXP3), which encodes a key regulator of immune tolerance. The aim of this study was to describe the clinical heterogeneity of the disease in a national French cohort.

Methods: Multicenter retrospective study of patients diagnosed with IPEX syndrome caused by mutations in FOXP3. Read More

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http://www.nature.com/articles/s41424-018-0064-x
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http://dx.doi.org/10.1038/s41424-018-0064-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212456PMC
November 2018
10 Reads

Physical Activity, BMI, and Risk of Fecal Incontinence in the Nurses' Health Study.

Clin Transl Gastroenterol 2018 Oct 25;9(10):200. Epub 2018 Oct 25.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women.

Methods: We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses' Health Study among 51,708 women who were free of FI in 2008. Read More

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http://dx.doi.org/10.1038/s41424-018-0068-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200735PMC
October 2018
6 Reads

Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome.

Clin Transl Gastroenterol 2018 Oct 25;9(10):199. Epub 2018 Oct 25.

Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Introduction: There is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome. Read More

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http://www.nature.com/articles/s41424-018-0067-7
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http://dx.doi.org/10.1038/s41424-018-0067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200756PMC
October 2018
9 Reads

Long-Term Follow-Up of Low-Risk Branch Duct IPMNs of the Pancreas: Watch for Main Pancreatic Duct Dilatation, and for How Long?

Clin Transl Gastroenterol 2018 Oct 24;9(10):198. Epub 2018 Oct 24.

Section of Digestive Disease, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41424-018-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199261PMC
October 2018
1 Read

Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE Study).

Clin Transl Gastroenterol 2018 Oct 15;9(10):197. Epub 2018 Oct 15.

Digestive & Liver Disease Unit, Sant'Andrea Hospital, "La Sapienza", Rome, Italy.

Background: Osteopathy is common in patients with chronic pancreatitis (CP), but previous studies carry several limitations. Vitamin K is essential for bone metabolism, but its role in this setting has never been investigated. Our aim is to assess the prevalence of osteoporosis and osteopenia in CP patients, and to investigate the association between osteopathy and CP features and nutritional parameters, especially vitamin D and K levels. Read More

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http://www.nature.com/articles/s41424-018-0066-8
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http://dx.doi.org/10.1038/s41424-018-0066-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189068PMC
October 2018
8 Reads

Correction: A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.

Clin Transl Gastroenterol 2018 Oct 8;9(10):192. Epub 2018 Oct 8.

Center for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.

A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis. Read More

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http://www.nature.com/articles/s41424-018-0062-z
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http://dx.doi.org/10.1038/s41424-018-0062-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175837PMC
October 2018
2 Reads

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors.

Clin Transl Gastroenterol 2018 Oct 8;9(10):196. Epub 2018 Oct 8.

Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.

Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear.

Methods: Here, we systematically evaluated the expression levels (by quantitative-PCR) of key ghrelin system components of in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) and normal tissues (NT; n = 14). Then, we analyzed their putative associations with clinical-histological characteristics. Read More

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http://dx.doi.org/10.1038/s41424-018-0058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175927PMC
October 2018
3 Reads

Correction: The Type of Bariatric Surgery Impacts the Risk of Acute Pancreatitis: A Nationwide Study.

Clin Transl Gastroenterol 2018 Oct 8;9(10):193. Epub 2018 Oct 8.

Division of Gastroenterology, Hepatology, & Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

In the original version of this Article, a footnote was missing. The PDF and HTML versions of the Article have now been corrected to include the following: This study was presented as an abstract at the World Congress of Gastroenterology (WCOG) at ACG 2017, Orlando Florida. Read More

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http://www.nature.com/articles/s41424-018-0063-y
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http://dx.doi.org/10.1038/s41424-018-0063-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175821PMC
October 2018
11 Reads

First Degree Relatives of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect them from Enterocyte Damage.

Clin Transl Gastroenterol 2018 Oct 8;9(10):195. Epub 2018 Oct 8.

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, 110029, India.

Introduction: Celiac disease (CeD) is an autoimmune enteropathy which affects approximately 0.7% of the global population. While first-degree relatives (FDR) of patients with CeD have a 7. Read More

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http://www.nature.com/articles/s41424-018-0059-7
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http://dx.doi.org/10.1038/s41424-018-0059-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174158PMC
October 2018
4 Reads

Response to Sachdeva et al: Brain Fogginess and SIBO Is Not a Mirage.

Clin Transl Gastroenterol 2018 Oct 5;9(10):194. Epub 2018 Oct 5.

Division of Gastroenterology/Hepatology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.

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http://www.nature.com/articles/s41424-018-0061-0
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http://dx.doi.org/10.1038/s41424-018-0061-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173778PMC
October 2018
2 Reads

Infected Pancreatic Necrosis due to Multidrug-Resistant Organisms and Persistent Organ failure Predict Mortality in Acute Pancreatitis.

Clin Transl Gastroenterol 2018 Oct 5;9(10):190. Epub 2018 Oct 5.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Background: Organ failure determines outcome in acute pancreatitis (AP). It is controversial if infected pancreatic necrosis (IPN) is also an independent determinant of mortality. We hypothesized that the predictors of mortality in AP might have changed with advances in management and consequent decline in mortality over the past decades. Read More

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http://www.nature.com/articles/s41424-018-0056-x
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http://dx.doi.org/10.1038/s41424-018-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172262PMC
October 2018
3 Reads

The Use of International Classification of Diseases Codes to Identify Patients with Pancreatitis: A Systematic Review and Meta-analysis of Diagnostic Accuracy Studies.

Clin Transl Gastroenterol 2018 Oct 4;9(10):191. Epub 2018 Oct 4.

Department of Surgery, University of Auckland, Auckland, New Zealand.

Background: Hospital discharge codes are increasingly used in gastroenterology research, but their accuracy in the setting of acute pancreatitis (AP) and chronic pancreatitis (CP), one of the most frequent digestive diseases, has never been assessed systematically. The aim was to conduct a systematic literature review and determine accuracy of diagnostic codes for AP and CP, as well as the effect of covariates.

Methods: Three databases (Pubmed, EMBASE and Scopus) were searched by two independent reviewers for relevant studies that used International Classification of Disease (ICD) codes. Read More

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http://www.nature.com/articles/s41424-018-0060-1
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http://dx.doi.org/10.1038/s41424-018-0060-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172207PMC
October 2018
13 Reads

Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.

Clin Transl Gastroenterol 2018 Sep 24;9(9):188. Epub 2018 Sep 24.

Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.

Background: Inflammatory bowel diseases (IBD) and asthma share genetic and environmental risk factors. Consequently, several observational studies have explored an association between IBD and asthma. We systematically reviewed and summarized the literature on the co-occurrence of asthma and IBD. Read More

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http://dx.doi.org/10.1038/s41424-018-0054-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155154PMC
September 2018
27 Reads

Association Between Type 2 Diabetes Mellitus, HbA1c and the Risk for Spontaneous Bacterial Peritonitis in Patients with Decompensated Liver Cirrhosis and Ascites.

Clin Transl Gastroenterol 2018 Sep 24;9(9):189. Epub 2018 Sep 24.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

Introduction: Type 2 diabetes mellitus (DM) is a frequent comorbidity among patients with liver cirrhosis. However, data regarding the impact of DM on spontaneous bacterial peritonitis (SBP) are quite limited. Our aim was to analyze the impact of DM and HbA1c values on the incidence of SBP and mortality in patients with liver cirrhosis and ascites. Read More

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http://dx.doi.org/10.1038/s41424-018-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155293PMC
September 2018
11 Reads

'Brain Fogginess' and D-Lactic Acidosis: Probiotics Are Not the Cause.

Clin Transl Gastroenterol 2018 Sep 24;9(9):187. Epub 2018 Sep 24.

Executive Science Officer, International Scientific Association for Probiotics and Prebiotics, 7119S. Glencoe Ct., Centennial, CO, 80122, USA.

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http://dx.doi.org/10.1038/s41424-018-0057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155354PMC
September 2018
4 Reads

Colorectal Cancer Screening Participation Among Asian Americans Overall and Subgroups in an Integrated Health Care Setting with Organized Screening.

Clin Transl Gastroenterol 2018 Sep 21;9(9):186. Epub 2018 Sep 21.

Kaiser Foundation Health Plan, Department of Regional Clinical Effectiveness, 393 East Walnut Street, Pasadena, CA, 91188, USA.

Background: Screening reduces colorectal cancer deaths, but <50% of Asian Americans are screening up-to-date according to surveys, with variability across Asian subgroups. We examined colorectal cancer screening participation among Asian Americans overall and Asian subgroups in a large integrated health care system with organized screening.

Methods: Data were electronically accessed to characterize screening in 2016 for Asians overall and subgroups relative to the National Colorectal Cancer Roundtable target of ≥80% screening and compared with non-Hispanic whites. Read More

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http://dx.doi.org/10.1038/s41424-018-0051-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155113PMC
September 2018
2 Reads

Meconium microbiome associates with the development of neonatal jaundice.

Clin Transl Gastroenterol 2018 Sep 20;9(9):182. Epub 2018 Sep 20.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Objective: Neonatal jaundice is a common disease that affects up to 60% of newborns. Gut microbiota mediated the excretion of bilirubin from the human body. However, the relationship between early gut microbiome and development of neonatal jaundice is not fully understood. Read More

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http://dx.doi.org/10.1038/s41424-018-0048-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147945PMC
September 2018
8 Reads

A Glycomarker for Short-term Prediction of Hepatocellular Carcinoma: A Longitudinal Study With Serial Measurements.

Clin Transl Gastroenterol 2018 Sep 20;9(9):183. Epub 2018 Sep 20.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

Objectives: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA-M2BP) is a glycomarker. The present community-based long-term follow-up study repeatedly determined the serum WFA-M2BP level and examined its short- and long-term associations with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).

Methods: A total of 921 participants with antibodies against HCV seropositive, but seronegative for hepatitis B surface antigen were enrolled from seven townships in Taiwan during 1991-1992. Read More

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http://www.nature.com/articles/s41424-018-0050-3
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http://dx.doi.org/10.1038/s41424-018-0050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148253PMC
September 2018
15 Reads

Barriers to Lynch Syndrome Testing and Preoperative Result Availability in Early-onset Colorectal Cancer: A National Physician Survey Study.

Clin Transl Gastroenterol 2018 Sep 20;9(9):185. Epub 2018 Sep 20.

Tulane University School of Medicine, Division of Gastroenterology. Staff Gastroenterologist Southeast Louisiana Veteran Health Care System, New Orleans, LA, USA.

Objective: Although widely recommended, Lynch syndrome (LS) testing with tumor microsatellite instability (MSI) and/or immunohistochemistry (IHC) is infrequently performed in early-onset colorectal cancer (CRC), and CRC generally. Reasons are poorly understood. Hence, we conducted a national survey focusing on gastroenterologists, as they are frequently first to diagnose CRC, assessing testing barriers and which specialist is felt responsible for ordering MSI/IHC. Read More

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http://dx.doi.org/10.1038/s41424-018-0047-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148048PMC
September 2018
2 Reads

Brain Fogginess and SIBO: A Link or Just a Mirage?

Clin Transl Gastroenterol 2018 Sep 20;9(9):184. Epub 2018 Sep 20.

Department of Gastroenterology, GB Pant Hospital, New Delhi, 110002, India.

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http://dx.doi.org/10.1038/s41424-018-0055-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147951PMC
September 2018
1 Read

Immune Checkpoint Inhibitor-Associated Colits and Hepatitis.

Clin Transl Gastroenterol 2018 Sep 19;9(9):180. Epub 2018 Sep 19.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Immune checkpoint inhibitors (ICPIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand PD-L1. ICPIs are now approved for the treatment of a wide array of malignancies, with rates of durable responses in the metastatic setting far exceeding what would be expected from conventional chemotherapy. ICPIs have also been associated with rare but serious immune-related adverse events due to over-activation of the immune system that can affect any organ, including the gastrointestinal tract and liver. Read More

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http://dx.doi.org/10.1038/s41424-018-0049-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143593PMC
September 2018
3 Reads

Combination of Gluten-Digesting Enzymes Improved Symptoms of Non-Celiac Gluten Sensitivity: A Randomized Single-blind, Placebo-controlled Crossover Study.

Clin Transl Gastroenterol 2018 Sep 19;9(9):181. Epub 2018 Sep 19.

Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.

Introduction: Recently, the population of individuals with non-celiac gluten sensitivity (NCGS) who do not have celiac disease but show improved symptoms with a gluten-free diet, has increased. Enzyme replacement therapy using digestive enzymes is expected to improve the symptoms of NCGS and be sustainable, since gluten-related proteins that are indigestible by the digestive system have been considered triggers of NCGS.

Methods: We selected patients with NCGS by screening demographic interviews, as well as performing medical evaluations, anti-gluten antibody tests, and gluten challenge tests. Read More

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http://dx.doi.org/10.1038/s41424-018-0052-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143542PMC
September 2018
2 Reads

The Type of Bariatric Surgery Impacts the Risk of Acute Pancreatitis: A Nationwide Study.

Clin Transl Gastroenterol 2018 Sep 12;9(9):179. Epub 2018 Sep 12.

Division of Gastroenterology, Hepatology, & Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: We investigated whether vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgery (RYGB) have a differential impact on post-operative risk of acute pancreatitis (AP).

Methods: This retrospective study uses the 2012-2014 National Readmission Database. We compared morbidly obese patients who underwent VSG (n = 205,251), RYGB (n = 169,973), and hernia repair (HR) control (n = 16,845). Read More

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http://dx.doi.org/10.1038/s41424-018-0045-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134111PMC
September 2018
2 Reads

A novel prognostic marker and immunogenic membrane antigen: prohibitin (PHB) in pancreatic cancer.

Clin Transl Gastroenterol 2018 Sep 6;9(9):178. Epub 2018 Sep 6.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 1 Shuai Fu Yuan Hu Tong, Beijing, 100730, China.

Background: Previous study, using immunoblotting with IgG and membrane proteins, identified prohibitin (PHB) as a potential immunogenic membrane antigen. Now, investigate PHB expression and biological functions in pancreatic cancer.

Methods: PHB expression was analysed in PDAC cell lines, normal pancreas tissues, cancer tissues, PDAC patient sera and healthy volunteer sera using QRT-PCR, Western blotting, IHC, and ELISA, and a survival analysis and a COX regression analysis were performed. Read More

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http://dx.doi.org/10.1038/s41424-018-0044-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125288PMC
September 2018
2 Reads

A Multi-Level Fit-Based Quality Improvement Initiative to Improve Colorectal Cancer Screening in a Managed Care Population.

Clin Transl Gastroenterol 2018 Sep 4;9(8):177. Epub 2018 Sep 4.

The Vatche & Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Introduction: Colorectal cancer (CRC) is a common but largely preventable disease with suboptimal screening rates despite national guidelines to screen individuals age 50-75. Single-component interventions aimed to improve screening uptake only modestly improve rates; data suggest that multi-modal approaches may be more effective.

Methods: We designed, implemented, and evaluated the impact of a multi-modal intervention on CRC screening uptake among unscreened patients in a large managed care population. Read More

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http://dx.doi.org/10.1038/s41424-018-0046-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120887PMC
September 2018
1 Read

A risk score model of 30-day readmission in ulcerative colitis after colectomy or proctectomy.

Clin Transl Gastroenterol 2018 Aug 15;9(8):175. Epub 2018 Aug 15.

Department of Gastroenterology, Springfield Regional Medical Center, Mercy Health, Springfield, OH, USA.

Introduction: The Center for Medicare and Medicaid Services established 30-day readmission rate as a key metric in measuring high-value, cost-conscious care; therefore, our aim is to develop a risk score for 30-day readmission in ulcerative colitis (UC) patients undergoing colectomy or proctectomy.

Methods: This study used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant user file (2011-2015). Patients with UC undergoing colectomy or proctectomy were identified using ICD-9, 10, and CPT codes. Read More

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http://dx.doi.org/10.1038/s41424-018-0039-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092348PMC
August 2018
9 Reads

Long-Term Outcome of Splanchnic Vein Thrombosis in Cirrhosis.

Clin Transl Gastroenterol 2018 Aug 15;9(8):176. Epub 2018 Aug 15.

Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.

Introduction: Little is known about the long-term outcome of cirrhotic patients with splanchnic vein thrombosis (SVT). This prospective cohort study aimed to describe the clinical presentation, bleeding incidence, thrombotic events, and mortality in patients with SVT associated with cirrhosis.

Methods: Among 604 consecutive patients with SVT enrolled over 2 years, 149 had cirrhosis. Read More

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http://dx.doi.org/10.1038/s41424-018-0043-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092393PMC
August 2018
2 Reads

Impact of scribing history and physical notes and procedure reports on endoscopist efficiency during routine procedures: a proof-of-concept study.

Clin Transl Gastroenterol 2018 Aug 10;9(8):174. Epub 2018 Aug 10.

Department of Medicine, Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Efficiency is an important aspect of endoscopic practice that has received limited study. We evaluated the impact of scribing electronic pre-procedure history and physical examinations, and electronic procedure reports on endoscopist efficiency.

Methods: We used a stopwatch to measure the time between the procedures (scope out to scope in), pre-procedure patient assessment time, and procedure report generation time for 180 consecutive procedures performed by a single endoscopist with or without a scribe for recording history and physical and procedure reports. Read More

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http://dx.doi.org/10.1038/s41424-018-0042-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085359PMC
August 2018
8 Reads

Correction: Long-term follow-up of low-risk branchduct IPMNs of the pancreas: is main pancreatic duct dilatation the most worrisome feature?

Clin Transl Gastroenterol 2018 08 1;9(7):173. Epub 2018 Aug 1.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.

In the HTML version of this paper Pietro Magnoni was incorrectly tagged as the corresponding author. The corresponding author should have been Maria Chiara Petrone. This has now been corrected in the HTML version of the paper. Read More

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http://www.nature.com/articles/s41424-018-0036-1
Publisher Site
http://dx.doi.org/10.1038/s41424-018-0036-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070478PMC
August 2018
5 Reads

Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.

Clin Transl Gastroenterol 2018 07 31;9(7):172. Epub 2018 Jul 31.

Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA.

The original version of this article contained an error in Fig. 2, in which part of the text in the legend was omitted. This has now been corrected in the PDF and HTML versions of the paper. Read More

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http://dx.doi.org/10.1038/s41424-018-0040-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068199PMC
July 2018
2 Reads

Correction: Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis.

Clin Transl Gastroenterol 2018 07 24;9(7):171. Epub 2018 Jul 24.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. Read More

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http://dx.doi.org/10.1038/s41424-018-0041-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057882PMC
July 2018
1 Read

A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.

Clin Transl Gastroenterol 2018 07 6;9(7):170. Epub 2018 Jul 6.

Center for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.

Objectives: Adsorptive granulomonocytapheresis (GMA) with the Adacolumn has been introduced as a non-pharmacologic treatment for ulcerative colitis (UC). However, a subset of patients who might respond well to GMA needs to be targeted. This study was conducted at three IBD centers to determine factors affecting the efficacy of GMA in patients with moderately-to-severely active UC. Read More

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http://dx.doi.org/10.1038/s41424-018-0037-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033883PMC
July 2018
19 Reads

Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis.

Clin Transl Gastroenterol 2018 07 6;9(7):169. Epub 2018 Jul 6.

Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada.

Introduction: Behavioral symptoms are commonly reported by patients with primary biliary cholangitis (PBC). In other patient populations, symptoms are commonly associated with hippocampal volume reduction linked to neuroinflammation (inferred from regional iron deposition), as demonstrated by magnetic resonance imaging (MRI). We hypothesized that PBC patients would exhibit reduced volume and increased iron deposition of the hippocampus. Read More

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http://dx.doi.org/10.1038/s41424-018-0038-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033882PMC
July 2018
8 Reads

Direct comparison of ten quantitative fecal immunochemical tests for hemoglobin stability in colorectal cancer screening.

Clin Transl Gastroenterol 2018 07 6;9(7):168. Epub 2018 Jul 6.

Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Objectives: To systematically investigate and directly compare, for the first time, the sample stability of a large number of quantitative fecal immunochemical tests (FITs) at different storage conditions.

Methods: Stool samples were obtained from participants of the German screening colonoscopy program between 2005 and 2010. After an initial FIT-based hemoglobin (Hb) measurement, stool samples were kept frozen at -80 °C until analysis. Read More

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http://dx.doi.org/10.1038/s41424-018-0035-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033915PMC
July 2018
5 Reads

Dexmedetomidine for conscious sedation with colorectal endoscopic submucosal dissection: a prospective double-blind randomized controlled study.

Clin Transl Gastroenterol 2018 07 4;9(7):167. Epub 2018 Jul 4.

Department of Gastroenterology and Hepatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, 730-8518, Japan.

Objective: Conscious sedation for colorectal endoscopic submucosal dissection (ESD) has not been standardized, and there are no studies of sedation for colorectal ESD.

Methods: We conducted a prospective double-blind randomized controlled trial to clarify the usefulness of DEX during colorectal ESD. In total 80 patients with colorectal ESD from April 2016 to May 2017 were assigned to the placebo group or the DEX group (40 cases each). Read More

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http://dx.doi.org/10.1038/s41424-018-0032-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030068PMC
July 2018
8 Reads