373 results match your criteria Clinical and Translational Gastroenterology [Journal]


Development and Validation of Confocal Endomicroscopy Diagnostic Criteria for Low-Grade Dysplasia in Barrett's Esophagus.

Clin Transl Gastroenterol 2019 Apr 11. Epub 2019 Apr 11.

MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.

Objectives: Low-grade dysplasia (LGD) in Barrett's esophagus (BE) is generally inconspicuous on conventional and magnified endoscopy. Probe-based confocal laser endomicroscopy (pCLE) provides insight into gastro-intestinal mucosa at cellular resolution. We aimed to identify endomicroscopic features and develop pCLE diagnostic criteria for BE-related LGD. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000014DOI Listing
April 2019
1 Read

Portal Vein Thrombosis in Decompensated Cirrhosis: Rationale for Treatment.

Clin Transl Gastroenterol 2019 Apr 2. Epub 2019 Apr 2.

Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.

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http://dx.doi.org/10.14309/ctg.0000000000000026DOI Listing

Elbasvir/Grazoprevir in People With Hepatitis C Genotype 1 Infection and Child-Pugh Class B Cirrhosis: The C-SALT Study.

Clin Transl Gastroenterol 2019 Mar 28. Epub 2019 Mar 28.

Department of Infectious Disease, Merck & Co., Inc., Kenilworth, New Jersey, USA.

Introduction: Treatment options are limited for people infected with hepatitis C virus (HCV) with decompensated liver disease. The C-SALT study assessed elbasvir (EBR) plus grazoprevir (GZR) in individuals with HCV genotype 1 infection and Child-Pugh class B (CP-B) cirrhosis.

Methods: In this 12-week, phase 2, nonrandomized, open-label study (NCT02115321; Protocol MK-5172-059), participants with CP-B cirrhosis received EBR 50 mg plus GZR 50 mg once daily, and a control group of noncirrhotic participants received EBR 50 mg plus GZR 100 mg once daily. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000007DOI Listing
March 2019
2 Reads

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt.

Clin Transl Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Introduction: Muscle mass has been shown to be a prognostic marker in patients with liver cirrhosis. Transversal psoas muscle thickness normalized by height (TPMT/height) obtained by routine computed tomography is a simple surrogate parameter for sarcopenia. TPMT/height, however, is not sex specific, which might play a role in risk stratification. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000025DOI Listing
March 2019
1 Read

A Novel, Duodenal-Release Formulation of a Combination of Caraway Oil and L-Menthol for the Treatment of Functional Dyspepsia: A Randomized Controlled Trial.

Clin Transl Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

IM Health Science, Boca Raton, Florida, USA.

Objectives: We conducted a randomized, placebo-controlled trial, which evaluated a novel formulation of caraway oil and L-menthol using microsphere-based site-specific targeting (COLM-SST) vs placebo in patients with functional dyspepsia (FD).

Methods: Adult men and women with FD defined by Rome III criteria were recruited. Patients were randomized to COLM-SST (25 mg of caraway oil and 20. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000021DOI Listing
March 2019
1 Read

Lipopolysaccharides From Non-Helicobacter pylori Gastric Bacteria Potently Stimulate Interleukin-8 Production in Gastric Epithelial Cells.

Clin Transl Gastroenterol 2019 Mar;10(3):e00024

Division of Gastroenterology, Department of Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan.

Background: Gastric acid secretion is compromised in chronic Helicobacter pylori (H. pylori) infection allowing overgrowth of non-H. pylori gastric bacteria (NHGB) in the stomach. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000024DOI Listing

Big Dreams With Big Data! Use of Clinical Informatics to Inform Biomarker Discovery.

Authors:
Siddharth Singh

Clin Transl Gastroenterol 2019 Mar;10(3):e00018

Division of Gastroenterology and Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA.

As the complexity of biomedical data increases, so do the opportunities to leverage them to advance science and clinical care. Electronic health records form a rich but complex source of large amounts of data gathered during routine clinical care. Through the use of codified and free-text concepts identified using clinical informatics tools such as natural language processing, disease phenotyping can be performed with a high degree of accuracy. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000018DOI Listing
March 2019
5 Reads

Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis.

Clin Transl Gastroenterol 2019 Mar;10(3):e00013

Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Introduction: Malnutrition is a leading cause of morbidity and mortality in cirrhosis. Although multiple noninvasive measures of nutritional status have been studied, no consensus exists for early identification of malnutrition in cirrhosis. Serum metabolomics offers a novel approach for identifying biomarkers in multiple disease states. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000013DOI Listing

Noninvasive Diagnosis of Irritable Bowel Syndrome via Bowel Sound Features: Proof of Concept.

Clin Transl Gastroenterol 2019 Mar;10(3):e00017

Marshall Centre, The University of Western Australia, Perth, Western Australia, Australia.

Introduction: Irritable bowel syndrome (IBS) is a common and debilitating disorder estimated to affect approximately 11% of the world's population. Typically, IBS is a diagnosis of exclusion after patients undergo a costly and invasive colonoscopy to exclude organic disease. Clinician's and researchers have identified a need for a new cost-effective, accurate, and noninvasive diagnostic test for IBS. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000017DOI Listing
March 2019
1 Read

A Novel Approach for the Genetic Analysis of Biliary Tract Cancer Specimens Obtained Through Endoscopic Ultrasound-Guided Fine Needle Aspiration Using Targeted Amplicon Sequencing.

Clin Transl Gastroenterol 2019 Mar;10(3):e00022

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Sapporo, Japan.

Objectives: Biliary tract cancer (BTC) is an aggressive malignant tumor, and biomarker-based clinical trials for this cancer are currently ongoing. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a safe procedure and enables pathological diagnoses; however, it is uncertain whether a tiny tumor sample of BTC obtained through EUS-FNA can be analyzed for diverse genetic alterations in the development and tolerance of BTC. Thus, we aimed to verify the feasibility of genetic analyses with EUS-FNA samples of BTC. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000022DOI Listing
March 2019
1 Read

Modulatory Effects of Pregnancy on Inflammatory Bowel Disease.

Clin Transl Gastroenterol 2019 Mar;10(3):e00009

Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.

The disease course of autoimmune diseases such as rheumatoid arthritis is altered during pregnancy, and a similar modulatory role of pregnancy on inflammatory bowel disease (IBD) has been proposed. Hormonal, immunological, and microbial changes occurring during normal pregnancy may interact with the pathophysiology of IBD. IBD consists of Crohn's disease and ulcerative colitis, and because of genetic, immunological, and microbial differences between these disease entities, they may react differently during pregnancy and should be described separately. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000009DOI Listing
March 2019
1 Read

Mucosal Healing Is Associated With the Reduced Disabling Disease in Crohn's Disease.

Clin Transl Gastroenterol 2019 Mar;10(3):e00015

Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Objectives: Mucosal healing (MH) is the goal of the "treat to target" strategy in Crohn's disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000015DOI Listing

Identifying Clonal Origin of Multifocal Hepatocellular Carcinoma and Its Clinical Implications.

Clin Transl Gastroenterol 2019 Feb;10(2):e00006

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.

Hepatocellular carcinoma (HCC) is characterized by high prevalence of multifocality. Multifocal HCC can arise synchronously or metachronously either from intrahepatic metastasis (IM) or multicentric occurrence (MO). To date, there have been no established criteria to accurately distinguish whether multifocal HCC originates from IM or MO. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407817PMC
February 2019
1 Read

Alterations of Gut Microbiota in Patients With Irritable Bowel Syndrome Based on 16S rRNA-Targeted Sequencing: A Systematic Review.

Clin Transl Gastroenterol 2019 Feb;10(2):e00012

Department of Gastroenterology, Peking University Third Hospital, Beijing, China.

Introduction: Alterations of gut microbiota have been thought to be associated with irritable bowel syndrome (IBS). Many studies have reported significant alterations of gut microbiota in patients with IBS based on 16S ribosomal RNA-targeted sequencing. However, results from these studies are inconsistent or even contradictory. Read More

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http://Insights.ovid.com/crossref?an=01720094-201902000-0000
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http://dx.doi.org/10.14309/ctg.0000000000000012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407812PMC
February 2019
4 Reads

Impact of Non-Alcoholic Fatty Liver Disease on Cardiovascular Outcomes in Patients With Stable Coronary Artery Disease: A Matched Case-Control Study.

Clin Transl Gastroenterol 2019 Feb;10(2):e00011

Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. This work was partially supported by the Capital Health Development Fund (grant number 201614035) and CAMS Major Collaborative Innovation Project (grant number 2016-I2M-1-011) awarded to J.-J.L.

Introduction: Whether non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular risk has still been controversial. The reasons for this disparity may be associated with subject selection, events definition, diagnostic criteria of NAFLD, or research methods. The aim of this study was to determine the relationship of NAFLD to cardiovascular disease (CVD) outcomes in patients with stable, new-onset coronary artery disease (CAD). Read More

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http://dx.doi.org/10.14309/ctg.0000000000000011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407808PMC
February 2019
17 Reads

Strategies to Improve Follow-up After Positive Fecal Immunochemical Tests in a Community-Based Setting: A Mixed-Methods Study.

Clin Transl Gastroenterol 2019 Feb;10(2):e00010

Kaiser Permanente Division of Research, Oakland, California, USA.

Objectives: The effectiveness of fecal immunochemical test (FIT) screening for colorectal cancer depends on timely colonoscopy follow-up of positive tests, although limited data exist regarding effective system-level strategies for improving follow-up rates.

Methods: Using a mixed-methods design (qualitative and quantitative), we first identified system-level strategies that were implemented for improving timely follow-up after a positive FIT test in a large community-based setting between 2006 and 2016. We then evaluated changes in time to colonoscopy among FIT-positive patients across 3 periods during the study interval, controlling for screening participant age, sex, race/ethnicity, comorbidity, FIT date, and previous screening history. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407828PMC
February 2019

Risk of Upper Gastrointestinal Bleeding and Gastroduodenal Ulcers in Persons With Schizophrenia: A Danish Cohort Study.

Clin Transl Gastroenterol 2019 Feb;10(2):e00005

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.

Introduction: There is little evidence about gastrointestinal (GI) disorders in patients with schizophrenia. We examined association of schizophrenia with upper GI bleeding (UGIB) and nonbleeding ulcers and associated risk factors and mortality.

Methods: We used the data linked from population-based registries in Denmark. Read More

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http://Insights.ovid.com/crossref?an=01720094-201902000-0000
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http://dx.doi.org/10.14309/ctg.0000000000000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407813PMC
February 2019
4 Reads

Diagnostic and Therapeutic Long-term Management of Eosinophilic Esophagitis- Current Concepts and Perspectives for Steroid Use.

Clin Transl Gastroenterol 2018 Dec;9(12):e212

Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN, USA.

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus, which requires short- and long-term treatment. In addition, patients under long-term treatment for any chronic condition should have a structured follow-up. The mainstays in EoE treatment are drugs (such as swallowed topical corticosteroids [STC] and proton pump inhibitors), dietary exclusions, and endoscopic dilations. Read More

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http://dx.doi.org/10.1038/s41424-018-0074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303250PMC
December 2018
1 Read

Home Blenderized Tube Feeding: A Practical Guide for Clinical Practice.

Authors:
Caroline Weeks

Clin Transl Gastroenterol 2019 Feb;10(2):e00001

Blank Children's Hospital Pediatric Gastroenterology Clinic, Des Moines, Iowa, USA.

Although commercial enteral formulas have been available on the market for several decades, a cultural shift toward consuming unprocessed foods with minimally added sugar has sparked interest in the preparation of home blenderized tube feedings for enteral feeding-dependent patients. Recent surveys, however, indicate lack of clinical awareness or familiarity in the management of this method of nutrition support. This article aims to equip the gastroenterologist with a guide for initiation, monitoring, and evaluation of a blenderized tube feedings regimen, and provides insights into an opportunity for greater partnership between the gastrointestinal provider and registered dietitian. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000001DOI Listing
February 2019
3 Reads

Plasma MicroRNA Signature Validation for Early Detection of Colorectal Cancer.

Clin Transl Gastroenterol 2019 Jan;10(1):e00003

Advanced Marker Discovery (Amadix), Valladolid, Spain.

Objectives: Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369870PMC
January 2019
3 Reads

Common NOD2 Risk Variants as Major Susceptibility Factors for Bacterial Infections in Compensated Cirrhosis.

Clin Transl Gastroenterol 2019 Jan;10(1):e00002

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Objectives: Common nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants have been associated with bacterial infections (BIs) in cirrhosis, in particular, spontaneous bacterial peritonitis, and mortality. Our aim was to evaluate the independent association of NOD2 variants with BI according to the decompensation stage.

Methods: Consecutive patients with cirrhosis in 2 academic medical centers were included and genotyped for the NOD2 variants p. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369875PMC
January 2019
2 Reads

Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival.

Clin Transl Gastroenterol 2019 Jan;10(1):e00004

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, China.

Objectives: Molecular prognostic biomarkers for gastric cancer (GC) are still limited. We aimed to identify potential messenger RNAs (mRNAs) associated with GC prognosis and further establish an mRNA signature to predict the survival of GC based on the publicly accessible databases.

Methods: Discovery of potential mRNAs associated with GC survival was undertaken for 441 patients with GC based on the Cancer Genome Atlas (TCGA), with information on clinical characteristics and vital status. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369880PMC
January 2019

A Multicenter, Randomized, Controlled Trial of Rebamipide Plus Lansoprazole for the Treatment of Postendoscopic Submucosal Dissection Ulcers.

Clin Transl Gastroenterol 2019 Jan;10(1):e00008

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

Objectives: To evaluate the healing efficacy of rebamipide and lansoprazole combination therapy with lansoprazole alone for endoscopic submucosal dissection (ESD)-induced ulcers and clarify the ulcer healing-associated factors.

Methods: Three hundred patients were randomized into control and experimental groups after they underwent ESD. The patients received intravenous pantoprazole (30 mg) every 12 hours and oral rebamipide (100 mg, experimental group) or placebo (control group) 3 times daily on days 1-3. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369969PMC
January 2019
1 Read

Splanchnic Vein Thrombosis in Cirrhosis - Areas Still in the Shadow.

Clin Transl Gastroenterol 2018 Dec 7;9(12):211. Epub 2018 Dec 7.

Department of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, "St. Spiridon" University Hospital, Gastroenterology and Hepatology Institute, 16 Universității St, 700115, Iași, Romania.

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http://dx.doi.org/10.1038/s41424-018-0079-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283861PMC
December 2018
2 Reads

Topical Analgesia with Lidocaine Plus Diclofenac Decreases Pain in Benign Anorectal Surgery: Randomized, Double-blind, and Controlled Clinical Trial.

Clin Transl Gastroenterol 2018 Nov 23;9(11):210. Epub 2018 Nov 23.

Drug Development Services, Pharmacy and Pharmaceutical Technology and Physical Chemistry Department, University of Barcelona, Barcelona, Spain.

Objective: The aim of this study is to evaluate the efficacy and safety of a topical formulation containing lidocaine plus diclofenac (CLIFE1) compared to lidocaine (CLIFE2), to decrease pain in benign anorectal surgery (BARS) to date not evaluated. More than 50% of patients undergoing BARS, especially hemorrhoidectomy, suffer from moderate and severe postoperative pain. This remains an unresolved problem that could be addressed with the new CLIFE1 topical treatment. Read More

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http://dx.doi.org/10.1038/s41424-018-0075-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250696PMC
November 2018
15 Reads

Correction: The Use of International Classification of Diseases Codes to Identify Patients with Pancreatitis: A Systematic Review and Meta-analysis of Diagnostic Accuracy Studies.

Clin Transl Gastroenterol 2018 Nov 21;9(11):209. Epub 2018 Nov 21.

Department of Surgery, University of Auckland, Auckland, New Zealand.

The original version of this Article presented incorrect information for citation 50. This has now been corrected in both the PDF and HTML versions of the Article. Petrov, M. Read More

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http://dx.doi.org/10.1038/s41424-018-0078-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249208PMC
November 2018
11 Reads

Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia.

Clin Transl Gastroenterol 2018 Nov 19;9(11):208. Epub 2018 Nov 19.

Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, University of Leuven, Leuven, Belgium.

Objectives: Achalasia is a primary esophageal motility disorder resulting from selective loss of inhibitory neurons in the esophageal myenteric plexus, likely due to an autoimmune response with involvement of the adaptive immune system. Innate immune processes of the host constitute the bridge between environmental etiological factors and the adaptive immune system. Although these remain poorly investigated, they might be of diagnostic and therapeutic relevance. Read More

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http://www.nature.com/articles/s41424-018-0076-6
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http://dx.doi.org/10.1038/s41424-018-0076-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240577PMC
November 2018
12 Reads

Probiotics can Cause D-Lactic Acidosis and Brain Fogginess: Reply to Quigley et al.

Clin Transl Gastroenterol 2018 Nov 19;9(11):207. Epub 2018 Nov 19.

Division of Neurogastroenterology/Motility, Department of Medicine, Augusta University Medical Center, Augusta, GA, USA.

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http://dx.doi.org/10.1038/s41424-018-0077-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240559PMC
November 2018
3 Reads

Correction: Immune Checkpoint Inhibitor-Associated Colitis and Hepatitis.

Clin Transl Gastroenterol 2018 Nov 14;9(11):206. Epub 2018 Nov 14.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

The original version of this Article contained an error in the spelling of colitis in the article title. It was incorrectly spelt as "colits". This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://www.nature.com/articles/s41424-018-0072-x
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http://dx.doi.org/10.1038/s41424-018-0072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235959PMC
November 2018
28 Reads

Correction: A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.

Clin Transl Gastroenterol 2018 Nov 14;9(11):205. Epub 2018 Nov 14.

Center for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.

This Article was originally published under Nature Research's License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly. Read More

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http://www.nature.com/articles/s41424-018-0073-9
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http://dx.doi.org/10.1038/s41424-018-0073-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235902PMC
November 2018
14 Reads

SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis.

Clin Transl Gastroenterol 2018 Nov 12;9(11):204. Epub 2018 Nov 12.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Objectives: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and clinical outcomes, as well as their potential interactions with environmental risk factors, remain unclear. These issues are addressed here in a large Chinese CP cohort. Read More

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http://dx.doi.org/10.1038/s41424-018-0069-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232107PMC
November 2018
29 Reads

Prognostic Value of MicroRNAs in Esophageal Carcinoma: A Meta-Analysis.

Clin Transl Gastroenterol 2018 Nov 13;9(11):203. Epub 2018 Nov 13.

The Second Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Background: Numerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC.

Methods: Studies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors. Read More

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http://Insights.ovid.com/crossref?an=01720094-201811000-0000
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http://dx.doi.org/10.1038/s41424-018-0070-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232177PMC
November 2018
18 Reads

Genotype Matters in Patients with Acute-on-chronic Liver Failure Due to Reactivation of Chronic Hepatitis B.

Clin Transl Gastroenterol 2018 Nov 12;9(11):202. Epub 2018 Nov 12.

Department of Gastroenterology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China, 650101.

Background: Acute-on-chronic liver failure (ACLF) can be caused by reactivation of chronic hepatitis B virus (HBV) infection (HBV-ACLF). It's unclear whether HBV genotypes affect the clinical and therapeutical outcomes of patients with HBV-ACLF. This study was to investigate the short-term antiviral response and overall survival in HBV-ACLF patients treated by tenofovir or entecavir. Read More

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http://dx.doi.org/10.1038/s41424-018-0071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230554PMC
November 2018
15 Reads

Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study.

Clin Transl Gastroenterol 2018 Nov 2;9(10):201. Epub 2018 Nov 2.

Université Paris Descartes-Sorbonne Paris Cité, Paris, France.

Objective: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disease caused by mutations in the forkhead box protein 3 gene (FOXP3), which encodes a key regulator of immune tolerance. The aim of this study was to describe the clinical heterogeneity of the disease in a national French cohort.

Methods: Multicenter retrospective study of patients diagnosed with IPEX syndrome caused by mutations in FOXP3. Read More

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http://www.nature.com/articles/s41424-018-0064-x
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http://dx.doi.org/10.1038/s41424-018-0064-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212456PMC
November 2018
10 Reads

Physical Activity, BMI, and Risk of Fecal Incontinence in the Nurses' Health Study.

Clin Transl Gastroenterol 2018 Oct 25;9(10):200. Epub 2018 Oct 25.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women.

Methods: We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses' Health Study among 51,708 women who were free of FI in 2008. Read More

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http://dx.doi.org/10.1038/s41424-018-0068-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200735PMC
October 2018
7 Reads

Increasing Dietary Fiber Intake Is Associated with a Distinct Esophageal Microbiome.

Clin Transl Gastroenterol 2018 Oct 25;9(10):199. Epub 2018 Oct 25.

Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Introduction: There is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome. Read More

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http://www.nature.com/articles/s41424-018-0067-7
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http://dx.doi.org/10.1038/s41424-018-0067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200756PMC
October 2018
9 Reads

Long-Term Follow-Up of Low-Risk Branch Duct IPMNs of the Pancreas: Watch for Main Pancreatic Duct Dilatation, and for How Long?

Clin Transl Gastroenterol 2018 Oct 24;9(10):198. Epub 2018 Oct 24.

Section of Digestive Disease, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41424-018-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199261PMC
October 2018
1 Read

Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE Study).

Clin Transl Gastroenterol 2018 Oct 15;9(10):197. Epub 2018 Oct 15.

Digestive & Liver Disease Unit, Sant'Andrea Hospital, "La Sapienza", Rome, Italy.

Background: Osteopathy is common in patients with chronic pancreatitis (CP), but previous studies carry several limitations. Vitamin K is essential for bone metabolism, but its role in this setting has never been investigated. Our aim is to assess the prevalence of osteoporosis and osteopenia in CP patients, and to investigate the association between osteopathy and CP features and nutritional parameters, especially vitamin D and K levels. Read More

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http://www.nature.com/articles/s41424-018-0066-8
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http://dx.doi.org/10.1038/s41424-018-0066-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189068PMC
October 2018
9 Reads

Correction: A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.

Clin Transl Gastroenterol 2018 Oct 8;9(10):192. Epub 2018 Oct 8.

Center for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan.

A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis. Read More

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http://www.nature.com/articles/s41424-018-0062-z
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http://dx.doi.org/10.1038/s41424-018-0062-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175837PMC
October 2018
3 Reads

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors.

Clin Transl Gastroenterol 2018 Oct 8;9(10):196. Epub 2018 Oct 8.

Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain.

Objectives: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear.

Methods: Here, we systematically evaluated the expression levels (by quantitative-PCR) of key ghrelin system components of in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) and normal tissues (NT; n = 14). Then, we analyzed their putative associations with clinical-histological characteristics. Read More

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http://dx.doi.org/10.1038/s41424-018-0058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175927PMC
October 2018
5 Reads

Correction: The Type of Bariatric Surgery Impacts the Risk of Acute Pancreatitis: A Nationwide Study.

Clin Transl Gastroenterol 2018 Oct 8;9(10):193. Epub 2018 Oct 8.

Division of Gastroenterology, Hepatology, & Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

In the original version of this Article, a footnote was missing. The PDF and HTML versions of the Article have now been corrected to include the following: This study was presented as an abstract at the World Congress of Gastroenterology (WCOG) at ACG 2017, Orlando Florida. Read More

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http://www.nature.com/articles/s41424-018-0063-y
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http://dx.doi.org/10.1038/s41424-018-0063-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175821PMC
October 2018
13 Reads

First Degree Relatives of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect them from Enterocyte Damage.

Clin Transl Gastroenterol 2018 Oct 8;9(10):195. Epub 2018 Oct 8.

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, 110029, India.

Introduction: Celiac disease (CeD) is an autoimmune enteropathy which affects approximately 0.7% of the global population. While first-degree relatives (FDR) of patients with CeD have a 7. Read More

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http://www.nature.com/articles/s41424-018-0059-7
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http://dx.doi.org/10.1038/s41424-018-0059-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174158PMC
October 2018
4 Reads

Response to Sachdeva et al: Brain Fogginess and SIBO Is Not a Mirage.

Clin Transl Gastroenterol 2018 Oct 5;9(10):194. Epub 2018 Oct 5.

Division of Gastroenterology/Hepatology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.

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http://www.nature.com/articles/s41424-018-0061-0
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http://dx.doi.org/10.1038/s41424-018-0061-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173778PMC
October 2018
2 Reads

Infected Pancreatic Necrosis due to Multidrug-Resistant Organisms and Persistent Organ failure Predict Mortality in Acute Pancreatitis.

Clin Transl Gastroenterol 2018 Oct 5;9(10):190. Epub 2018 Oct 5.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Background: Organ failure determines outcome in acute pancreatitis (AP). It is controversial if infected pancreatic necrosis (IPN) is also an independent determinant of mortality. We hypothesized that the predictors of mortality in AP might have changed with advances in management and consequent decline in mortality over the past decades. Read More

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http://www.nature.com/articles/s41424-018-0056-x
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http://dx.doi.org/10.1038/s41424-018-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172262PMC
October 2018
3 Reads

The Use of International Classification of Diseases Codes to Identify Patients with Pancreatitis: A Systematic Review and Meta-analysis of Diagnostic Accuracy Studies.

Clin Transl Gastroenterol 2018 Oct 4;9(10):191. Epub 2018 Oct 4.

Department of Surgery, University of Auckland, Auckland, New Zealand.

Background: Hospital discharge codes are increasingly used in gastroenterology research, but their accuracy in the setting of acute pancreatitis (AP) and chronic pancreatitis (CP), one of the most frequent digestive diseases, has never been assessed systematically. The aim was to conduct a systematic literature review and determine accuracy of diagnostic codes for AP and CP, as well as the effect of covariates.

Methods: Three databases (Pubmed, EMBASE and Scopus) were searched by two independent reviewers for relevant studies that used International Classification of Disease (ICD) codes. Read More

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http://www.nature.com/articles/s41424-018-0060-1
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http://dx.doi.org/10.1038/s41424-018-0060-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172207PMC
October 2018
15 Reads

Co-occurrence of Asthma and the Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.

Clin Transl Gastroenterol 2018 Sep 24;9(9):188. Epub 2018 Sep 24.

Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.

Background: Inflammatory bowel diseases (IBD) and asthma share genetic and environmental risk factors. Consequently, several observational studies have explored an association between IBD and asthma. We systematically reviewed and summarized the literature on the co-occurrence of asthma and IBD. Read More

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http://dx.doi.org/10.1038/s41424-018-0054-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155154PMC
September 2018
33 Reads

Association Between Type 2 Diabetes Mellitus, HbA1c and the Risk for Spontaneous Bacterial Peritonitis in Patients with Decompensated Liver Cirrhosis and Ascites.

Clin Transl Gastroenterol 2018 Sep 24;9(9):189. Epub 2018 Sep 24.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

Introduction: Type 2 diabetes mellitus (DM) is a frequent comorbidity among patients with liver cirrhosis. However, data regarding the impact of DM on spontaneous bacterial peritonitis (SBP) are quite limited. Our aim was to analyze the impact of DM and HbA1c values on the incidence of SBP and mortality in patients with liver cirrhosis and ascites. Read More

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http://dx.doi.org/10.1038/s41424-018-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155293PMC
September 2018
11 Reads

'Brain Fogginess' and D-Lactic Acidosis: Probiotics Are Not the Cause.

Clin Transl Gastroenterol 2018 Sep 24;9(9):187. Epub 2018 Sep 24.

Executive Science Officer, International Scientific Association for Probiotics and Prebiotics, 7119S. Glencoe Ct., Centennial, CO, 80122, USA.

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http://dx.doi.org/10.1038/s41424-018-0057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155354PMC
September 2018
4 Reads

Colorectal Cancer Screening Participation Among Asian Americans Overall and Subgroups in an Integrated Health Care Setting with Organized Screening.

Clin Transl Gastroenterol 2018 Sep 21;9(9):186. Epub 2018 Sep 21.

Kaiser Foundation Health Plan, Department of Regional Clinical Effectiveness, 393 East Walnut Street, Pasadena, CA, 91188, USA.

Background: Screening reduces colorectal cancer deaths, but <50% of Asian Americans are screening up-to-date according to surveys, with variability across Asian subgroups. We examined colorectal cancer screening participation among Asian Americans overall and Asian subgroups in a large integrated health care system with organized screening.

Methods: Data were electronically accessed to characterize screening in 2016 for Asians overall and subgroups relative to the National Colorectal Cancer Roundtable target of ≥80% screening and compared with non-Hispanic whites. Read More

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http://dx.doi.org/10.1038/s41424-018-0051-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155113PMC
September 2018
3 Reads