301 results match your criteria Clinical and Translational Gastroenterology [Journal]


Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection.

Clin Transl Gastroenterol 2018 Jun 19;9(6):163. Epub 2018 Jun 19.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Background: Mac-2-binding protein glycosylation isomer (M2BPGi), a novel serum marker for liver fibrosis, was seldom studied in chronic hepatitis B (CHB). We aimed to evaluate its role on diagnosing significant fibrosis and cirrhosis in treated CHB patients.

Methods: CHB patients treated with nucleos(t)ide analogues (NAs) with baseline liver biopsies and retrievable serum samples were recruited. Read More

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June 2018
1 Read

Characteristics of the bacterial microbiome in association with common intestinal parasites in irritable bowel syndrome.

Clin Transl Gastroenterol 2018 Jun 19;9(6):161. Epub 2018 Jun 19.

Department of Gastroenterology, Zealand University Hospital, Lykkebækvej 1, DK-4600, Køge, Denmark.

Objective: A low prevalence of intestinal parasites has been identified in individuals with irritable bowel syndrome (IBS), but potential associations with alterations in the bacterial microbiome remain largely unexplored. We aimed to investigate the relationship between parasites and bacteria in individuals with IBS in order to identify potential trans-kingdom microbial characteristics.

Design: Stool samples were collected from the Danish background population classified into IBS (n = 119), unspecific gastrointestinal (GI) symptoms (n = 114), and asymptomatic controls (n = 186) based on the Rome III criteria for IBS. Read More

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Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.

Clin Transl Gastroenterol 2018 Jun 19;9(6):162. Epub 2018 Jun 19.

Division of Gastroenterology/Hepatology, Department of Internal Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.

Background: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). Read More

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Decreased monocyte shedding of the migration inhibitor soluble CD18 in alcoholic hepatitis.

Clin Transl Gastroenterol 2018 Jun 15;9(6):160. Epub 2018 Jun 15.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Objectives: During alcoholic hepatitis (AH) monocytes traverse the vascular boundaries and massively invade the liver. In principle, tissue extravasation can be limited through shedding of CD18 integrins from leukocytes, including monocytes. The soluble (s) product sCD18 conceals adhesion receptors on the endothelium, which reduces monocyte extravasation. Read More

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Predictive factors of submucosal fibrosis before endoscopic submucosal dissection for superficial squamous esophageal neoplasia.

Clin Transl Gastroenterol 2018 Jun 15;9(6):159. Epub 2018 Jun 15.

Department of Pathology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Objectives: Endoscopic submucosal dissection (ESD) is an effective treatment modality for superficial squamous esophageal neoplasia (SSEN). However, submucosal fibrosis is an important obstacle to successful ESD. The aim of this study was to determine the ESD outcome in relationship to the degree of submucosal fibrosis of SSEN and to identify factors for predicting submucosal fibrosis. Read More

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June 2018
3 Reads

Long-term follow-up of low-risk branch-duct IPMNs of the pancreas: is main pancreatic duct dilatation the most worrisome feature?

Clin Transl Gastroenterol 2018 Jun 13;9(6):158. Epub 2018 Jun 13.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: The management of branch-duct IPMN remains controversial due to the relatively low rate of malignant degeneration and the uncertain predictive role of high-risk stigmata (HRS) and worrisome features (WFs) identified by the 2012 International Consensus Guidelines. Our aim was to evaluate the evolution of originally low-risk (Fukuoka-negative) BD-IPMNs during a long follow-up period in order to determine whether the appearance of any clinical or morphological variables may be independently associated with the development of malignancy over time.

Methods: A prospectively collected database of all patients with BD-IPMN referring to our Institute between 2002 and 2016 was retrospectively analyzed. Read More

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June 2018
2 Reads

Oxidative stress as a biomarker for monitoring treated celiac disease.

Clin Transl Gastroenterol 2018 Jun 8;9(6):157. Epub 2018 Jun 8.

Center for Prevention and Diagnosis of Celiac Disease- Div. of Gastroenterology and Endoscopy, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milano, Italy.

Introduction: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD.

Methods: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD). Read More

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Preliminary esophageal microbiome studies prompt important scientific questions.

Clin Transl Gastroenterol 2018 May 29;9(5):156. Epub 2018 May 29.

Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt Medical Center, Nashville, TN, USA.

Analysis of the esophageal microbiome remains a new field of research. Two hypothesis-generating papers published in the current issue of the Journal go beyond characterizing the esophageal microbiome in Barrett's esophagus or eosinophilic esophagitis (EoE). Snider et al. Read More

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Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.

Clin Transl Gastroenterol 2018 May 25;9(5):155. Epub 2018 May 25.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Background: Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated with beneficial metabolic effects. However, the direct effect of oral butyrate on metabolic parameters in humans has never been studied. In this first in men pilot study, we thus treated both lean and metabolic syndrome male subjects with oral sodium butyrate and investigated the effect on metabolism. Read More

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May 2018
3 Reads

Left gastric vein-based noninvasive test for esophageal varices: a same-day comparison of portal hemodynamic assessment with endoscopic appearance.

Clin Transl Gastroenterol 2018 May 25;9(5):154. Epub 2018 May 25.

Department of Gastroenterology, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, 260-8670, Japan.

Objective: To examine the effect of hemodynamic assessment of the left gastric vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients.

Methods: This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11. Read More

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Aspirin: the miracle drug?

Clin Transl Gastroenterol 2018 May 2;9(5):153. Epub 2018 May 2.

Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA.

Aspirin use is associated with reduction of esophageal adenocarcinoma but it is not known if it does so by preventing the development of Barrett's esophagus or by reducing neoplastic progression in patients with Barrett's esophagus. There is sparse literature to support the former assumption especially in women. This study by Jovani et al. Read More

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Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer.

Clin Transl Gastroenterol 2018 Apr 30;9(4):152. Epub 2018 Apr 30.

Erasmus MC Cancer Institute, 's-Gravendijkwal 230, Rotterdam, 3015 CE, The Netherlands.

Introduction: Esophageal cancer is an increasingly common type of neoplasm with a very poor prognosis. This prognosis could improve with more early tumor detection. We have previously shown that we can use an optical spectroscopy to detect field cancerization in the buccal mucosa of patients with laryngeal cancer. Read More

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Sequencing of intraductal biopsies is feasible and potentially impacts clinical management of patients with indeterminate biliary stricture and cholangiocarcinoma.

Clin Transl Gastroenterol 2018 Apr 30;9(4):151. Epub 2018 Apr 30.

Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Background: Definite diagnosis and therapeutic management of cholangiocarcinoma (CCA) remains a challenge. The aim of the current study was to investigate feasibility and potential impact on clinical management of targeted sequencing of intraductal biopsies.

Methods: Intraductal biopsies with suspicious findings from 16 patients with CCA in later clinical course were analyzed with targeted sequencing including tumor and control benign tissue (n = 55 samples). Read More

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Toll-like receptors-mediated pathways activate inflammatory responses in the esophageal mucosa of adult eosinophilic esophagitis.

Clin Transl Gastroenterol 2018 Apr 25;9(4):147. Epub 2018 Apr 25.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.

Objectives: Esophageal microbiota and regulation of adaptive immunity are increasingly being investigated in eosinophilic esophagitis (EoE). Toll-like receptors (TLRs) play a central role in the initiation and maintenance of innate immune activity. Our objective was to characterize the esophageal and duodenal innate immune response in EoE and its modulation by dietary therapy. Read More

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April 2018
3 Reads

Blood transfusion strategies for acute upper gastrointestinal bleeding: are we back where we started?

Authors:
Andrew W Yen

Clin Transl Gastroenterol 2018 Apr 25;9(4):150. Epub 2018 Apr 25.

Division of Gastroenterology, Sacramento VA Medical Center, Veterans Affairs Northern California Health Care System (VANCHCS), University of California Davis School of Medicine, Sacramento, USA.

Blood transfusion practices for acute upper gastrointestinal hemorrhage have changed over time. Restrictive strategies, which gave way to more liberal approaches for the greater part of the 20 century, have again gained traction as emerging research suggests restricting transfusion is associated with similar, or possibly better outcomes in UGI bleeding. In a large, retrospective cohort study from an integrated health care system in Taiwan, Chen, et al. Read More

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April 2018
3 Reads

Mental and physical health-related quality of life in patients with hepatitis C is related to baseline comorbidities and improves only marginally with hepatitis C cure.

Clin Transl Gastroenterol 2018 Apr 25;9(4):149. Epub 2018 Apr 25.

Institute of Digestive Health & Liver diseases, Mercy Medical Center, Baltimore, MD, USA.

The objective of the study was to analyze the relationship between patient characteristics and the health-related quality of life (HRQoL) among patients with hepatitis C at the start of treatment, 2-12 weeks of treatment and ≥3 months post treatment using Short-Form 36 (SF-36). The eight domains and two composite scores of SF-36 were analyzed using 236 individuals. Compared to US general population norms, on average, the physical health scores were significantly lower for the studied hepatitis C population, while the differences related to mental health were between zero and small. Read More

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Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule.

Clin Transl Gastroenterol 2018 Apr 25;9(4):144. Epub 2018 Apr 25.

Division of Gastroenterology, Center for Neurointestinal Health, Massachusetts General Hospital, Boston, MA, USA.

Background: Chronic constipation may be categorized as normal transit (NTC), slow transit (STC), or outlet obstruction. Colonic wake response is a relative increase in colonic motility upon awakening. Colonic manometry studies have demonstrated attenuated wake response in STC. Read More

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Does colectomy predispose to small intestinal bacterial (SIBO) and fungal overgrowth (SIFO)?

Clin Transl Gastroenterol 2018 Apr 25;9(4):146. Epub 2018 Apr 25.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Augusta University, Augusta, GA, 30912, USA.

Objectives: After subtotal colectomy, 40% of patients report chronic gastrointestinal symptoms and poor quality of life. Its etiology is unknown. We determined whether small intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth (SIFO) cause gastrointestinal symptoms after colectomy. Read More

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Plasma inflammatory cytokines and survival of pancreatic cancer patients.

Clin Transl Gastroenterol 2018 Apr 25;9(4):145. Epub 2018 Apr 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

Objectives: Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal model studies. The goal of the present study is to identify plasma markers of inflammation associated with survival of pancreatic cancer patients, and assess their joint contribution to patient outcome.

Methods: We measured circulating levels of four established markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor type II (sTNF-RII), and macrophage inhibitory cytokine-1 (MIC-1)) in 446 patients enrolled in an ongoing prospective clinic-based study. Read More

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Primary care colorectal cancer screening correlates with breast cancer screening: implications for colorectal cancer screening improvement interventions.

Clin Transl Gastroenterol 2018 Apr 25;9(4):148. Epub 2018 Apr 25.

University of Wisconsin Carbone Cancer Center, Madison, WI, USA.

Objective: National colorectal cancer (CRC) screening rates have plateaued. To optimize interventions targeting those unscreened, a better understanding is needed of how this preventive service fits in with multiple preventive and chronic care needs managed by primary care providers (PCPs). This study examines whether PCP practices of other preventive and chronic care needs correlate with CRC screening. Read More

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Risk of thrombosis and mortality in inflammatory bowel disease.

Clin Transl Gastroenterol 2018 Apr 3;9(4):142. Epub 2018 Apr 3.

Laboratório de Investigação Médica (LIM-07), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Objectives: Patients with inflammatory bowel disease have a higher risk of thrombosis, which is associated with a higher morbidity and mortality. Most data about VTE are related to hospitalized patients with active disease, but several cases happen in the outpatient setting, and are not covered by current prophylaxis recommendation. As the knowledge of VTE in outpatients is still poor, the aim of this study is to evaluate the risk, clinical data and mortality of thrombosis in patients followed in our center, comparing our findings with the current prophylaxis recommendation. Read More

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April 2018
1 Read

Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.

Clin Transl Gastroenterol 2018 Apr 3;9(4):143. Epub 2018 Apr 3.

Department of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA.

Objectives: Infants exposed to combination therapy with anti-tumor necrosis factor (anti-TNF) agents and thiopurines may exhibit increased infections at 1 year of age compared to unexposed infants. We hypothesized that this increased risk of infection is due to abnormal development of the newborn immune system.

Methods: We immunophenotyped B-cell and T-cell subsets using multiparameter flow cytometry in 1-year-old infants whose mothers were exposed to therapeutic agents for IBD. Read More

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April 2018
1 Read

The association between red blood cell transfusion and outcomes in patients with upper gastrointestinal bleeding.

Clin Transl Gastroenterol 2018 Mar 29;9(3):138. Epub 2018 Mar 29.

Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan, No. 6, W. Sec., Jiapu Rd., Puzih City, Chiayi County, 613, Taiwan.

Background: The benefits of transfusion for acute upper gastrointestinal bleeding (UGIB) have not been well established; however, previous studies suggest that transfusion is associated with adverse outcomes. We performed an observational study using a 10-year database to analyze the association between red blood cell (RBC) transfusion and outcomes in patients with UGIB in the emergency department (ED).

Method And Findings: All adult patients with UGIB were identified through diagnostic codes. Read More

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March 2018
1 Read

Baclofen and gastroesophageal reflux disease: seeing the forest through the trees.

Clin Transl Gastroenterol 2018 Mar 29;9(3):137. Epub 2018 Mar 29.

Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE) Division of Gastroenterology & Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABA agonists in long-term treatment of GERD. Read More

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March 2018
2 Reads

Increasing co-morbidities in chronic hepatitis B patients: experience in primary care and referral practices during 2000-2015.

Clin Transl Gastroenterol 2018 Mar 14;9(3):141. Epub 2018 Mar 14.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford University, Stanford, CA, USA.

Objectives: Data on liver and non-liver co-morbidities in chronic hepatitis B (CHB) patients are limited. This study analyzes the prevalence of co-morbidities in a multicenter CHB cohort evaluated over 15 years.

Methods: This study included 2734 consecutive adult American CHB patients from a university medical center and several community primary care clinics. Read More

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March 2018
1 Read

Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis.

Clin Transl Gastroenterol 2018 Mar 6;9(3):139. Epub 2018 Mar 6.

Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide polymorphism position RS3806932. Presently, the phenotypic characteristics in EoE children with the TSLP EoE risk allele are unknown. Read More

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March 2018
1 Read

Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis.

Clin Transl Gastroenterol 2018 Mar 6;9(3):140. Epub 2018 Mar 6.

Center for the Study of Coagulation Disorders in Liver Disease, Division of Gastroenterology & Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.

Objective: Patients with cirrhosis are at increased risk for venous thromboembolism (VTE) and portal vein thrombosis (PVT). Cirrhosis due to non-alcoholic steatohepatitis (NASH) appears to be particularly prothrombotic. We investigated hospitalized patients with NASH cirrhosis to determine if they are at increased risk for VTE. Read More

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March 2018
2 Reads

Barrett's esophagus is associated with a distinct oral microbiome.

Clin Transl Gastroenterol 2018 Feb 20;9(3):135. Epub 2018 Feb 20.

Department of Medicine, Columbia University Medical Center, New York, NY, USA.

Objectives: The esophageal microbiome is composed of predominantly oral flora and is altered in reflux-related conditions including Barrett's esophagus (BE). Changes to the esophageal microbiome may be reflected in the oral cavity. Assessing the oral microbiome thus represents a potential non-invasive method to identify patients with BE. Read More

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February 2018
2 Reads

Endoscopic score vs. fecal biomarkers for predicting relapse in patients with ulcerative colitis after clinical remission and mucosal healing.

Clin Transl Gastroenterol 2018 Feb 20;9(3):136. Epub 2018 Feb 20.

Inflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Mie, Japan.

Achieving endoscopic remission or decreasing the level of fecal biomarkers as an ideal therapeutic goal in ulcerative colitis has not been determined. This prospective study was to compare the clinical relevance of endoscopic score with fecal biomarkers for predicting relapse after clinical remission and mucosal healing (MH). One hundred and sixty-four patients who achieved clinical remission and MH (Mayo endoscopic subscore (MES) 0 or 1) were included. Read More

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February 2018
1 Read

Gut Microbiota-Based Therapies for Irritable Bowel Syndrome.

Clin Transl Gastroenterol 2018 Feb 15;9(2):e134. Epub 2018 Feb 15.

Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Irritable bowel syndrome (IBS) is a common, heterogeneous disorder characterized by abdominal pain associated with changes in bowel habits. The pathogenesis of IBS is multifactorial and may relate to alterations in the gut microbiota, changes in visceral sensation and motility, and genetic and environmental factors. Administration of systemic antibiotics may increase the risk of IBS by altering gastrointestinal homeostasis. Read More

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February 2018
4 Reads

Antibodies against glycoprotein 2 display diagnostic advantages over ASCA in distinguishing CD from intestinal tuberculosis and intestinal Behçet's disease.

Clin Transl Gastroenterol 2018 Feb 15;9(2):e133. Epub 2018 Feb 15.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: There is an increasing need to identify reliable biomarkers for distinguishing Crohn's disease (CD) from other gastrointestinal disorders sharing similar clinical and pathological features. This study aimed at evaluating the diagnostic potential of antibodies to zymogen granule glycoprotein GP2 (aGP2) in a large, well-defined Chinese cohort with a special focus on their role in discriminating CD from intestinal Behçet's disease (BD) and intestinal tubercolosis (ITB).

Methods: A total of 577 subjects were prospectively enrolled, including 171 patients with CD, 208 patients with ulcerative colitis (UC), 71 with BD, 57 with ITB and 70 healthy controls (HC). Read More

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February 2018
5 Reads

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease.

Clin Transl Gastroenterol 2018 Jan 18;9(1):e132. Epub 2018 Jan 18.

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Objectives: Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in genetically susceptible individuals. New technologies support the joint assessment of host-microbiome interaction.

Methods: Using whole genome sequencing and shotgun metagenomics, we studied the clinical features, host genome, and stool microbial metagenome of 85 IBD patients, and compared the results to 146 control individuals. Read More

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January 2018
2 Reads

Endoscopic Resection for Early-Stage Esophageal Cancer, Are We There for Squamous As Well?

Clin Transl Gastroenterol 2017 Dec 14;8(12):e130. Epub 2017 Dec 14.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Superficial esophageal squamous cell cancer (SESCC) is often managed with esophagectomy with or without chemoradiotherapy. Esophagectomy has a significant complication rate and is not an option for many patients. In the current issue, a retrospective single center study evaluated 66 patients with SESCC. Read More

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December 2017
2 Reads

Which Patients with Mild Acute Pancreatitis Require Prolonged Hospitalization?

Clin Transl Gastroenterol 2017 Dec 7;8(12):e129. Epub 2017 Dec 7.

Division of Gastroenterology, Hepatology and Nutrition, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Objectives: In our experience, a subset of mild acute pancreatitis (AP) patients, as defined by the Revised Atlanta Classification, has longer than expected hospitalization. Our aims are to report the prevalence of patients with mild AP who have a prolonged length of stay (LOS), evaluate the etiology, thoroughly phenotype, and finally compare this subset to those with expected LOS.

Methods: Patients admitted with AP from 2003 to 2015 were prospectively enrolled into this cohort study. Read More

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December 2017
4 Reads

Inflammatory Bowel Disease Adversely Impacts Colorectal Cancer Surgery Short-term Outcomes and Health-Care Resource Utilization.

Clin Transl Gastroenterol 2017 Nov 30;8(11):e127. Epub 2017 Nov 30.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

Objectives: Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) compared to patients without IBD. There is a lack of population-based data evaluating the in-patient surgical outcomes of CRC in IBD patients. We sought to compare the hospital outcomes of CRC surgery between patients with and without IBD. Read More

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November 2017
6 Reads

Blood-Based Protein Signatures for Early Detection of Colorectal Cancer: A Systematic Review.

Clin Transl Gastroenterol 2017 Nov 30;8(11):e128. Epub 2017 Nov 30.

Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Objectives: Blood-based proteins might be an attractive option for early detection of colorectal cancer (CRC), but individually they are unlikely to achieve the diagnostic performance required for population based screening. We aimed at summarizing current evidence of diagnostic performance of signatures based on multiple proteins for early detection of CRC.

Methods: A systematic literature review adhering to the PRISMA (preferred reporting items for systematic reviews and meta-analysis) guidelines was performed. Read More

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November 2017
5 Reads

Centrally Determined Standardization of Flow Cytometry Methods Reduces Interlaboratory Variation in a Prospective Multicenter Study.

Clin Transl Gastroenterol 2017 Nov 2;8(11):e126. Epub 2017 Nov 2.

Division of Gastroenterology, School of Medicine, University of California San Diego, San Diego, CA, USA.

Objectives: Flow cytometry (FC) aids in characterization of cellular and molecular factors involved in pathologic immune responses. Although FC has potential to facilitate early drug development in inflammatory bowel disease, interlaboratory variability limits its use in multicenter trials. Standardization of methods may address this limitation. Read More

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November 2017
8 Reads

Comparison of Impedance and Pepsin Detection in the Laryngeal Mucosa to Determine Impedance Values that Indicate Pathological Laryngopharyngeal Reflux.

Clin Transl Gastroenterol 2017 Oct 26;8(10):e123. Epub 2017 Oct 26.

Department of Otorhinolaryngology, University Hospital Ostrava, Ostrava, Czech Republic.

Objective: Recently, a 24-h impedance was used to detect laryngopharyngeal reflux (LPR). However, not every case of LPR is pathological. Thus, pathological pharyngeal impedance values need to be clearly established to diagnose pathological LPR. Read More

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October 2017
2 Reads

Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels.

Clin Transl Gastroenterol 2017 Oct 26;8(10):e125. Epub 2017 Oct 26.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.

Objectives: We aimed to determine the levels of alanine aminotransferase (ALT), hepatitis B virus DNA (HBV DNA), HBsAg, and a novel viral marker (hepatitis B core-related antigen (HBcrAg)); hepatitis B e antigen (HBeAg) seroconversion and drug resistance rates after 7 years of entecavir treatment in chronic hepatitis B (CHB) patients.

Methods: Two hundred and twenty-two Chinese CHB patients on continuous entecavir treatment were recruited. Serologic, virologic, biochemical outcomes, and the occurrence of entecavir signature mutations were determined. Read More

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October 2017
5 Reads

Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer.

Clin Transl Gastroenterol 2017 Oct 19;8(10):e124. Epub 2017 Oct 19.

Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Objectives: The basis for over-representation of colorectal cancer (CRC) in African-American (AA) populations compared with Caucasians are multifactorial and complex. Understanding the mechanisms for this racial disparity is critical for delivery of better care. Several studies have investigated sporadic CRC for differences in somatic mutations between AAs and Caucasians, but owing to small study sizes and conflicting results to date, no definitive conclusions have been reached. Read More

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October 2017
5 Reads

A New Preoperative Prognostic System Combining CRP and CA199 For Patients with Intrahepatic Cholangiocarcinoma.

Clin Transl Gastroenterol 2017 Oct 5;8(10):e118. Epub 2017 Oct 5.

Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Shanghai, China.

Objectives: In this study, we aimed at investigating the preoperatively available prognostic factors for intrahepatic cholangiocarcinoma (ICC) patients and proposing a new preoperative prognostic scoring system for ICC.

Methods: A total of 246 consecutive ICC patients who underwent curative hepatectomy were enrolled retrospectively and were randomly divided into training (n=164) and validation cohorts (n=82) at a ratio of 2:1. The prognostic factors were investigated in both cohorts using multivariate Cox's proportional hazards regression model. Read More

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October 2017
5 Reads

Influence of GABA-B Agonist Baclofen on Capsaicin-Induced Excitation of Secondary Peristalsis in Humans.

Clin Transl Gastroenterol 2017 Oct 5;8(10):e120. Epub 2017 Oct 5.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

Objectives: Esophageal instillation of capsaicin enhances secondary peristalsis, but the γ-aminobutyric acid receptor type B (GABA-B) agonist baclofen inhibits secondary peristalsis. This study aimed to investigate whether baclofen could influence heartburn perception and secondary peristalsis subsequent to capsaicin infusion in healthy adults.

Methods: Secondary peristalsis was performed by slow and rapid mid-esophagus air injections in 15 healthy subjects. Read More

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October 2017
4 Reads

Improvement in Esophageal Distensibility in Response to Medical and Diet Therapy in Eosinophilic Esophagitis.

Clin Transl Gastroenterol 2017 Oct 5;8(10):e119. Epub 2017 Oct 5.

Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Objectives: We aimed to evaluate the effect of medical and diet therapies on esophageal distensibility assessed using the functional lumen imaging probe (FLIP) and the association of changes in esophageal distensibility with clinical outcomes in eosinophilic esophagitis (EoE).

Methods: Patients with EoE were evaluated with FLIP during endoscopy at baseline and following therapy without interval dilatation. Evaluation also included a validated patient-reported outcome (PRO; a positive PRO was considered at a 30% score improvement), mucosal biopsies, and scoring of endoscopic features of EoE. Read More

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October 2017
3 Reads

Transmembrane TNF-α Density, but not Soluble TNF-α Level, is Associated with Primary Response to Infliximab in Inflammatory Bowel Disease.

Clin Transl Gastroenterol 2017 Sep 14;8(9):e117. Epub 2017 Sep 14.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Anti-tumor necrosis factor (TNF)-α agents like Infliximab (IFX) are effective in the treatment of inflammatory bowel diseases (IBDs) and are widely used. However, a considerable number of patients do not respond or lose response to this therapy. Preliminary evidence suggests that transmembrane TNF-α (tmTNF-α) might be linked to response to IFX by promoting reverse signaling-induced apoptosis in inflammatory cells. Read More

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September 2017
10 Reads

Endoscopic Drainage of >50% of Liver in Malignant Hilar Biliary Obstruction Using Metallic or Fenestrated Plastic Stents.

Clin Transl Gastroenterol 2017 Aug 31;8(8):e115. Epub 2017 Aug 31.

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA.

Objectives: Endoscopic drainage of complex hilar tumors has generally resulted in poor outcomes. Drainage of >50% of liver volume has been proposed as optimal, but not evaluated using long multifenestrated plastic stents (MFPS) or self-expanding metal stents (SEMS). We evaluated outcomes of endoscopic drainage of malignant hilar strictures using optimal strategy and stents, and determined factors associated with stent patency, survival, and complications. Read More

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August 2017
2 Reads

Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015.

Clin Transl Gastroenterol 2017 Aug 31;8(8):e116. Epub 2017 Aug 31.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.

Objectives: Studies on the epidemiology of primary biliary cholangitis (PBC) in the Chinese population are lacking. We aimed to determine the epidemiology of PBC in Hong Kong (HK) with a population of 7.3 million. Read More

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August 2017
9 Reads

Clinical and Histologic Mimickers of Celiac Disease.

Clin Transl Gastroenterol 2017 Aug 17;8(8):e114. Epub 2017 Aug 17.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and malabsorption. The diagnosis of celiac disease is made when there are compatible clinical features, supportive serologic markers, representative histology from the small bowel, and response to a gluten-free diet. Histologic findings associated with celiac disease include intraepithelial lymphocytosis, crypt hyperplasia, villous atrophy, and a chronic inflammatory cell infiltrate in the lamina propria. Read More

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August 2017
6 Reads

Impact of Fecal Hb Levels on Advanced Neoplasia Detection and the Diagnostic Miss Rate For Colorectal Cancer Screening in High-Risk vs. Average-Risk Subjects: a Multi-Center Study.

Clin Transl Gastroenterol 2017 Aug 10;8(8):e113. Epub 2017 Aug 10.

Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok, Thailand.

Objectives: The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to identify high-risk subjects for advanced neoplasia. However, the appropriate fecal immunochemical test (FIT) cutoff for high-risk population may be different from that of average-risk population. We aimed to evaluate the FIT performance at different cutoffs in high-risk subjects undergoing colorectal cancer (CRC) screening. Read More

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August 2017
14 Reads

Pancreatic and Intestinal Function Post Roux-en-Y Gastric Bypass Surgery for Obesity.

Clin Transl Gastroenterol 2017 Aug 3;8(8):e112. Epub 2017 Aug 3.

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Objectives: Despite the fact that the most effective treatment for morbid obesity today is gastric bypass surgery, some patients develop life-threatening nutritional complications associated with their weight loss.

Methods: Here we examine the influence of the altered anatomy and digestive physiology on pancreatic secretion and fat absorption. Thirteen post Roux-en-Y gastric bypass (RYGB) patients who had lost >100 lbs in the first year following surgery and who gave variable histories of gastrointestinal (GI) dysfunction, were selected for study. Read More

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August 2017
2 Reads