209 results match your criteria Clinical and Molecular Allergy [Journal]


PPI adverse drugs reactions: a retrospective study.

Clin Mol Allergy 2019 18;17. Epub 2019 Jan 18.

1School and Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Proton pump inhibitors (PPIs) are drugs capable of blocking the gastric pump H,K-ATPase in order to inhibit gastric acid secretion. Omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole belong to PPIs category. Although PPIs have a good safety profile, allergic reactions to these molecules can occur. Read More

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http://dx.doi.org/10.1186/s12948-019-0104-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337765PMC
January 2019

Comorbidities are associated with different features of severe asthma.

Clin Mol Allergy 2018 3;16:25. Epub 2018 Dec 3.

1Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.

Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. Read More

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http://dx.doi.org/10.1186/s12948-018-0103-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276160PMC
December 2018
3 Reads

Focus on the role of substance P in chronic urticaria.

Clin Mol Allergy 2018 19;16:24. Epub 2018 Nov 19.

4Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy.

Background: Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized.

Methods: Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. Read More

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http://dx.doi.org/10.1186/s12948-018-0101-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240950PMC
November 2018
2 Reads

Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E.

Clin Mol Allergy 2018 12;16:23. Epub 2018 Nov 12.

6Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.

Background: Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggrin protein, eosinophil major basic protein (MBP) and immunoglobulin E (IgE) to elicit allergic response or to contribute to atopic disorders remains largely unexplored in pediatric patients. This study was undertaken to investigate the status and contribution of filaggrin protein, eosinophil MBP and total IgE in pediatric patients with AD, AR and BA. Read More

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http://dx.doi.org/10.1186/s12948-018-0102-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233599PMC
November 2018
2 Reads

Rapid desensitization for brentuximab vedotin (Adceteris) allergy: a case report.

Clin Mol Allergy 2018 29;16:22. Epub 2018 Oct 29.

1Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy.

Background: Brentuximab vedotin (BV) is an antibody-drug conjugate formed by an anti-CD30 chimeric IgG conjugated with monomethyl-auristatin-E. BV targets the CD30 cells, which characterize Hodgkin lymphoma as well as anaplastic large cell lymphoma. Once bound to the CD30 cells BV exerts its cytotoxic effect via the monomethyl-auristatin-E moiety. Read More

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https://clinicalmolecularallergy.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s12948-018-0100-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205792PMC
October 2018
4 Reads

Drug induced Kounis syndrome: does oxidative stress play a role?

Clin Mol Allergy 2018 1;16:21. Epub 2018 Oct 1.

1Allergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G.Martino" Via Consolare Valeria 1, 98124 Messina, Italy.

Background: Kounis syndrome (KS) has been described as the coincidental occurrence of acute coronary syndromes during an allergic reaction with cardiac anaphylaxis. It is caused by inflammatory mediators released after exposure to drugs, food, environmental and other triggers. Oxidative stress occurring in various inflammatory disorders causes molecular damage with the production of advanced oxidation products (AOPPs) and advanced glycation end products (AGEs). Read More

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https://clinicalmolecularallergy.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s12948-018-0099-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166286PMC
October 2018
4 Reads

Urban air pollution and climate change: "The Decalogue: Allergy Safe Tree" for allergic and respiratory diseases care.

Clin Mol Allergy 2018 11;16:20. Epub 2018 Sep 11.

Air Pollution and Climate Change Task Force of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC), Milan, Italy.

Background: According to the World Health Organization, air pollution is closely associated with climate change and, in particular, with global warming. In addition to melting of ice and snow, rising sea level, and flooding of coastal areas, global warming is leading to a tropicalization of temperate marine ecosystems. Moreover, the effects of air pollution on airway and lung diseases are well documented as reported by the World Allergy Organization. Read More

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https://clinicalmolecularallergy.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s12948-018-0098-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134633PMC
September 2018
6 Reads

The involvement of osmolarity in the safety of contrast media.

Clin Mol Allergy 2018 3;16:19. Epub 2018 Sep 3.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Background: New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our study was to evaluate how osmolarity may affect safety in the use of contrast agents.

Case Presentation: Six patients with a positive history for reaction to contrast agent were included in this study. Read More

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http://dx.doi.org/10.1186/s12948-018-0097-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120064PMC
September 2018
3 Reads

Tryptase as a marker of severity of aortic valve stenosis.

Clin Mol Allergy 2018 7;16:17. Epub 2018 Aug 7.

The Department of Allergology and Immunology, A.S.S.T. Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Background: Severe aortic valve stenosis is one of the most common cause of mortality in adult patients affected with metabolic syndrome, a condition associated with an active inflammatory process involving also mast cells and their mediators, in particular tryptase. The aim of this study was to characterize the possible long-term prognostic role of tryptase in severe aortic valve stenosis.

Case Presentation: The baseline serum tryptase was measured in 5 consecutive patients admitted to our Hospital to undergo aortic valve replacement for severe acquired stenosis. Read More

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http://dx.doi.org/10.1186/s12948-018-0095-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080360PMC
August 2018
2 Reads

Focus on the agents most frequently responsible for perioperative anaphylaxis.

Clin Mol Allergy 2018 9;16:16. Epub 2018 Jul 9.

2Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo Moro, Bari, Italy.

Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). Read More

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http://dx.doi.org/10.1186/s12948-018-0094-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038250PMC
July 2018
9 Reads

House dust mite-related respiratory allergies and probiotics: a narrative review.

Clin Mol Allergy 2018 19;16:15. Epub 2018 Jun 19.

Allergy Therapeutics Italia, via IV Novembre 76, 20019 Settimo Milanese, Milan Italy.

The socio-economic burden of allergic respiratory conditions on continental Europe is even higher than that of mainstream diseases, such as diabetes and cardiovascular disease, as allergic rhinitis alone accounts for billions of Euros in healthcare expenses across Europe. House dust mites (HDM) are one of the most common triggers behind allergic rhinitis and asthma. The role of probiotics in the treatment and prevention of some allergic conditions, such as atopic dermatitis, is already well recognized, whereas evidence about their efficacy in patients with respiratory allergies-while increasing-is still limited. Read More

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http://dx.doi.org/10.1186/s12948-018-0092-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006752PMC
June 2018
2 Reads

Sublingual grass allergen specific immunotherapy: a retrospective study of clinical outcome and discontinuation.

Clin Mol Allergy 2018 8;16:14. Epub 2018 Jun 8.

1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Background: Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of treatment with SLIT against grass pollen allergy in a consecutive patient population.

Methods: Patients (n = 329) who were confirmed to be allergic to timothy grass and had been prescribed SLIT were consecutively enrolled in the study and completed a questionnaire online or in hard copy. Read More

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http://dx.doi.org/10.1186/s12948-018-0093-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994102PMC
June 2018
5 Reads

Regulation of IgE activity in inhalational tolerance via formation of IgG anti-IgE/IgE immune complexes.

Clin Mol Allergy 2018 18;16:13. Epub 2018 May 18.

1Department of Immunology, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT 06030 USA.

Background: Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is an effective therapy for asthma and other atopic disorders. However, the status of free IgE in subjects who have naturally developed immune tolerance to inhaled antigens has not been well studied. Read More

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http://dx.doi.org/10.1186/s12948-018-0091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960149PMC
May 2018
4 Reads

Low incidence of pneumonia in COPD patients treated with inhaled corticosteroids undergoing pulmonary rehabilitation.

Clin Mol Allergy 2018 16;16:12. Epub 2018 May 16.

Department of Rehabilitation and Functional Recovery, ASST Pini/CTO, Milan, Italy.

Background: Based on meta-analyses results, it is currently acknowledged that there is an increased risk of pneumonia in patients with chronic obstructive pulmonary disease (COPD) undergoing inhaled corticosteroids (ICS) treatment. However, this is not found to be true in those with asthma. No data on this risk are available for COPD patients involved in pulmonary rehabilitation program (PR). Read More

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http://dx.doi.org/10.1186/s12948-018-0090-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956951PMC
May 2018
4 Reads

How to fit allergen immunotherapy in the elderly.

Clin Mol Allergy 2017 6;15:17. Epub 2017 Oct 6.

Allergy and Respiratory Diseases Clinic, DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.

Asthma, allergic rhinitis (AR) and atopic dermatitis are very common in young people, but in the latest decades it was increasingly recognized that also individuals of higher ages, including the population over 65 years, are concerned. Actually, it is now acknowledged the aging does not considerably alter the immune response to allergens. Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy, but elderly people are commonly excluded from AIT, except the cases of insect sting allergy. Read More

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http://dx.doi.org/10.1186/s12948-017-0075-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951166PMC
October 2017
7 Reads

Involvement of miR-126 in autoimmune disorders.

Clin Mol Allergy 2018 2;16:11. Epub 2018 May 2.

1School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, Messina University Hospital, 98125 Messina, Italy.

Background: Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes, endothelial and lung cells. Some studies have shown the implication of miR-126 in cancer, but recently significant progresses have also been made in determining the role of miR-126 regulating immune-related diseases; probably, in a near future, they could potentially serve as diagnostic biomarkers or therapeutic targets.

Objective: The purpose of this review is to investigate the role of miR-126 in autoimmune diseases, so as to offer innovative therapies. Read More

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http://dx.doi.org/10.1186/s12948-018-0089-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930861PMC
May 2018
5 Reads

Hymenoptera sting reactions in southern Italy forestry workers: our experience compared to reported data.

Clin Mol Allergy 2018 17;16. Epub 2018 Apr 17.

1Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University of Messina, Messina, Italy.

Background: Hymenoptera sting reactions are among life-threatening causes of allergy. Several epidemiology studies have assessed the risk of these kind of reactions, among the general population, around 3% of adults. This incidence increases among highly at risk populations such as outdoor workers. Read More

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http://dx.doi.org/10.1186/s12948-018-0087-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902920PMC
April 2018
6 Reads

A case of atopic dermatitis caused by infection.

Clin Mol Allergy 2018 10;16:10. Epub 2018 Apr 10.

3School and Operative Unit of Allergy and Clinical Immunology Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Background: Parasite infections stimulate total and specific IgE production that, in the case of infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as infection. is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Read More

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http://dx.doi.org/10.1186/s12948-018-0088-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894144PMC
April 2018
4 Reads

Role of genetic variations of - in bronchial asthmatic patients.

Clin Mol Allergy 2018 2;16. Epub 2018 Apr 2.

1Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 0208505 Japan.

Background: Single nucleotide polymorphisms (SNPs) in - () are associated with bronchial severity and pulmonary function. CHI3L1 proteins are involved in both innate and adaptive immune responses; however, to date, the correlation of these SNPs and their age of onset of bronchial asthma has not been demonstrated.

Methods: To address the role of these genetic variations, 390 patients with well-controlled bronchial asthma and living in Japan were recruited, genotyped, and had a pulmonary function test performed on them in this study. Read More

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http://dx.doi.org/10.1186/s12948-018-0086-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880007PMC
April 2018
7 Reads

Importance of hypersensitivity in adverse reactions to drugs in the elderly.

Clin Mol Allergy 2018 2;16. Epub 2018 Apr 2.

4Medicine and Surgery Department, University of Parma, Via Gramsci 14, 43126 Parma, Italy.

Background: The use of drugs in the elderly is very extensive because of the frequent occurrence of chronic diseases. Adverse drug reactions (ADRs) commonly occur in geriatric patients receiving multiple therapeutic regimens. In the literature, little attention has been given to ADRs in the elderly, and particularly to allergic reactions. Read More

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http://dx.doi.org/10.1186/s12948-018-0083-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880019PMC
April 2018
23 Reads

Bench to bedside review of myositis autoantibodies.

Clin Mol Allergy 2018 7;16. Epub 2018 Mar 7.

Experimental and Clinical Medicine Department, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.

Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not been included, with the only exception of anti-Jo-1, into the 2017 Classification Criteria, thus perpetuating a clinical-serologic gap. The lack of homogeneous grouping based on the antibody profile deeply impacts the diagnostic approach, therapeutic choices and prognostic stratification of these patients. Read More

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https://clinicalmolecularallergy.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s12948-018-0084-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840827PMC
March 2018
9 Reads

A critical appraisal on AIT in childhood asthma.

Clin Mol Allergy 2018 6;16. Epub 2018 Mar 6.

2Personalized Medicine, Asthma and Allergy Clinic, Humanitas University and Research Hospital, Via Alessandro Manzoni 113, Rozzano, MI Italy.

Abstract: Allergen immunotherapy (AIT) is the only disease-modifying treatment approved for allergic rhinitis and allergic asthma and represents a suitable therapeutic option, especially in childhood, to modify the progression of respiratory allergic diseases. Starting from the previous "generic class effect" evaluation, as testified by the numerous meta analyses, AIT is now considered a product-specific pathogenic-oriented treatment.

Background: AIT was empirically proposed more than one century ago in the subcutaneous form (SCIT), but the IgE-mediated mechanism of allergy was elucidated only after 50 years of clinical use of the treatment. Read More

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http://dx.doi.org/10.1186/s12948-018-0085-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839070PMC
March 2018
19 Reads

The control of allergic rhinitis in real life: a multicenter cross-sectional Italian study.

Clin Mol Allergy 2018 2;16. Epub 2018 Feb 2.

8Allergy and Respiratory Diseases, IRCCS San Martino-IST University of Genoa, Genoa, Italy.

Background: Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. Read More

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http://dx.doi.org/10.1186/s12948-018-0082-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797368PMC
February 2018
6 Reads

Allergic sensitization to common pets (cats/dogs) according to different possible modalities of exposure: an Italian Multicenter Study.

Clin Mol Allergy 2018 2;16. Epub 2018 Feb 2.

34Allergy and Respiratory Diseases, Policlinico San Martino, University of Genoa, Genoa, Italy.

Background: The query "are there animals at home?" is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studies and in clinical practice. The aim of our study was to evaluate/quantify different modalities of exposure to cat/dog in inducing allergic sensitization. Read More

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http://dx.doi.org/10.1186/s12948-018-0081-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796344PMC
February 2018
3 Reads

A 13-year real-life study on efficacy, safety and biological effects of venom immunotherapy.

Clin Mol Allergy 2018 18;16. Epub 2018 Jan 18.

1School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation, University of Bari-Aldo Moro, Piazza Giulio Cesare 13, Policlinico, 70124 Bari, Italy.

Background: venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG, but the overall picture remains elusive. Read More

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http://dx.doi.org/10.1186/s12948-017-0079-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774115PMC
January 2018
10 Reads

Biological clocks: their relevance to immune-allergic diseases.

Clin Mol Allergy 2018 10;16. Epub 2018 Jan 10.

1Dipartimento di Medicina e Scienze dell'invecchiamento, Università "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini, 5, 66013 Chieti, Italy.

The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm. This regulates several activities, including sleep, feeding times, energy metabolism, endocrine and immune functions. Read More

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http://dx.doi.org/10.1186/s12948-018-0080-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763605PMC
January 2018
10 Reads

Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement.

Clin Mol Allergy 2017 22;15:22. Epub 2017 Dec 22.

Allergy Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Shariati Square, Mashhad, Iran.

Background: Spontaneous urticaria is a common allergic skin condition affecting 0.5-1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity.

Aim: In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Read More

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http://dx.doi.org/10.1186/s12948-017-0078-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740857PMC
December 2017
7 Reads

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation.

Clin Mol Allergy 2017 14;15:21. Epub 2017 Dec 14.

Dermatological Clinic, Department of Biomedical Science and Human Oncology, University of Bari Medical School, Policlinico, Italy.

Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). Read More

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http://dx.doi.org/10.1186/s12948-017-0077-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731094PMC
December 2017
7 Reads

Tiotropium in asthma: back to the future of anticholinergic treatment.

Clin Mol Allergy 2017 4;15:20. Epub 2017 Dec 4.

Department of Biomedicine and Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy.

Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic agents. Read More

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http://dx.doi.org/10.1186/s12948-017-0076-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713051PMC
December 2017
13 Reads

Selecting optimal second-generation antihistamines for allergic rhinitis and urticaria in Asia.

Clin Mol Allergy 2017 1;15:19. Epub 2017 Nov 1.

Personalised Medicine Asthma & Allergy Clinic, Humanitas University, Clinical & Research Hospital, Rozzano, Milan, Italy.

Background: Allergic diseases are on the rise in many parts of the world, including the Asia-Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinitis and urticaria. International guidelines describe the management of these conditions; however, clinicians perceive the additional need to tailor treatment according to patient profiles. Read More

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http://dx.doi.org/10.1186/s12948-017-0074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664819PMC
November 2017
24 Reads

High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi.

Clin Mol Allergy 2017 1;15:18. Epub 2017 Nov 1.

R&D, ImmunoDiagnostic Division, Thermo Fisher Scientific, Uppsala, Sweden.

Background: IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The potential clinical implication of such cross-reactivity is that allergens other than the known sensitizer can cause allergic symptoms. Read More

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http://dx.doi.org/10.1186/s12948-017-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664576PMC
November 2017
6 Reads

Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature.

Clin Mol Allergy 2017 4;15:16. Epub 2017 Oct 4.

Department of Allergology and Immunology, Ospedale Metropolitano Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy.

Background: Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or even other classes of drugs are prescribed in these patients, negatively affecting the efficacy of treatment and the course of the disease. The aim of this study was to analyse a group of six patients with severe cutaneous drug reactions induced by anticonvulsants and to report which alternative antiepileptic drugs and which drugs of other classes were tolerated. Read More

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http://dx.doi.org/10.1186/s12948-017-0072-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627447PMC
October 2017
17 Reads

A survey on the perception of allergy specialists about the reimbursed grass pollen tablets for seasonal allergic rhinitis in Italy.

Clin Mol Allergy 2017 15;15:15. Epub 2017 Aug 15.

Allergy and Pneumology Departmental Unit, Fondazione Poliambulanza Hospital, Brescia, Italy.

Background: Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit its prescription. In 2015, the 5-grass pollen tablets was authorized by the European Medicine Agency to treat grass-pollen induced rhinitis and was approved in Italy for full reimbursement. Read More

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http://dx.doi.org/10.1186/s12948-017-0071-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558723PMC
August 2017
7 Reads

Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature.

Clin Mol Allergy 2017 15;15:14. Epub 2017 Jun 15.

AN-Najah National University Teaching Hospital, Asira, Nablus, West bank Palestine.

Background: Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity reaction. This reaction can be ranged from mild cutaneous rash to anticonvulsant hypersensitivity syndrome (AHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) that includes fever, rash, eosinophilia and involvement of multiple internal organs. Read More

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http://clinicalmolecularallergy.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s12948-017-0069-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472963PMC
June 2017
17 Reads

Preventive actions of allergen immunotherapy: the facts and the effects in search of evidence.

Clin Mol Allergy 2017 15;15:13. Epub 2017 Jun 15.

Medicine and Surgery Department, University of Parma, via Gramsci n.14, 43126 Parma, Italy.

Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy. Available AIT nowadays are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis and asthma, while for allergy to venom only subcutaneous route is recommended. A bulk of trials and meta-analyses demonstrated that efficacy and safety of AIT in decreasing allergic clinical symptoms and use of rescue medications, while its preventive capacity is yet under investigation. Read More

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http://dx.doi.org/10.1186/s12948-017-0070-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471950PMC
June 2017
10 Reads
3 Citations

Association between HMGB1 and asthma: a literature review.

Clin Mol Allergy 2017 14;15:12. Epub 2017 Jun 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Background: Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation.

Objective: This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma. Read More

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http://dx.doi.org/10.1186/s12948-017-0068-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471678PMC
June 2017
9 Reads

Asthma management among allergists in Italy: results from a survey.

Clin Mol Allergy 2017 8;15:11. Epub 2017 May 8.

Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.

Background: In Europe more than 50% of asthmatic treated patients have not well-controlled asthma. Asthma affects about 2.5 million of patients in Italy. Read More

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http://dx.doi.org/10.1186/s12948-017-0067-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422900PMC
May 2017
8 Reads

The soft computing-based approach to investigate allergic diseases: a systematic review.

Clin Mol Allergy 2017 13;15:10. Epub 2017 Apr 13.

School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy.

Background: Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majority of studies in the literature are based on classic statistical methods; however, developments in computational techniques such as soft computing-based approaches hold new promise in this field.

Objective: The aim of this manuscript is to systematically review the main soft computing-based techniques such as artificial neural networks, support vector machines, bayesian networks and fuzzy logic to investigate their performances in the field of allergic diseases. Read More

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http://dx.doi.org/10.1186/s12948-017-0066-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390370PMC
April 2017
10 Reads

SANI-Severe Asthma Network in Italy: a way forward to monitor severe asthma.

Clin Mol Allergy 2017 10;15. Epub 2017 Apr 10.

Allergy & Respiratory Disease, DIMI-University of Genova, Largo Rosanna Benzi, 10, 16132 Genova, Italy.

Even if severe asthma (SA) accounts for 5-10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several networks, focused on SA have been organized in some countries, in order to select these patients, to recognize their clinical features, to evaluate their adherence, to classify their biological/clinical phenotypes, to identify their eligibility to the new biologic therapies and to quantify the costs of the disease. Aim of the present paper is to describe the ongoing Italian Severe Asthma Network (SANI). Read More

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http://dx.doi.org/10.1186/s12948-017-0065-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385599PMC
April 2017
5 Reads

Hypersensitivity reactions due to black henna tattoos and their components: are the clinical pictures related to the immune pathomechanism?

Clin Mol Allergy 2017 10;15. Epub 2017 Apr 10.

Section of Allergy and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.

Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various clinical aspects are described in literature due to PPD associated to henna tattoo and these manifestations are likely correlated with the immunological and dermatological pathomechanisms involved. Henna is the Persian name of the plant Fam. Read More

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http://dx.doi.org/10.1186/s12948-017-0063-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385600PMC
April 2017
18 Reads
1 Citation

Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study.

Clin Mol Allergy 2017 3;15. Epub 2017 Apr 3.

Children's Hospital for Lung Diseases and Tuberculosis, Medical Center "Dr. Dragiša Mišović", Belgrade, Pilota Mihajla Tepica 1, 11000 Belgrade, Serbia.

Background: Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy).

Methods: 7-18 years old children with allergic asthma and rhinitis were enrolled and addressed to the active (AIT plus pharmacological treatment) or control (standard pharmacological treatment only) group. Read More

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http://dx.doi.org/10.1186/s12948-017-0064-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376712PMC
April 2017
11 Reads

Hypersensitivity pneumonitis: a complex lung disease.

Clin Mol Allergy 2017 7;15. Epub 2017 Mar 7.

Division of Sub Acute Care, Sesto San Giovanni Hospital, ASST Nord Milano, Sesto San Giovanni, Italy.

Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Such reaction is secondary to a repeated and prolonged inhalation of different types of organic dusts or other substances to which the patient is sensitized and hyper responsive, primarily consisting of organic dusts of animal or vegetable origin, more rarely from chemicals. The prevalence of HP is difficult to evaluate because of uncertainties in detection and misdiagnosis and lacking of widely accepted diagnostic criteria, and varies considerably depending on disease definition, diagnostic methods, exposure modalities, geographical conditions, agricultural and industrial practices, and host risk factors. Read More

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http://dx.doi.org/10.1186/s12948-017-0062-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339989PMC
March 2017
14 Reads

Pharmacoeconomics of sublingual immunotherapy with the 5-grass pollen tablets for seasonal allergic rhinitis.

Clin Mol Allergy 2017 7;15. Epub 2017 Mar 7.

Department of Clinical & Experimental Medicine, University of Parma, Via Gramsci 14, Parma, Italy.

Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This particularly concerns allergen immunotherapy (AIT), that, based on its immunological action on the causes of allergy, extends its benefit also after discontinuation of the treatment. Read More

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http://dx.doi.org/10.1186/s12948-017-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340071PMC
March 2017
8 Reads

Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.

Clin Mol Allergy 2017 3;15. Epub 2017 Mar 3.

Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.

Background: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.

Methods: Three-hundred and four children (median age 13. Read More

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http://dx.doi.org/10.1186/s12948-017-0061-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335719PMC
March 2017
14 Reads

Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error.

Clin Mol Allergy 2017 8;15. Epub 2017 Feb 8.

Dipartimento Scienze della Salute, Università degli Studi di Milano, Milan, Italy.

Background: Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may be influenced by fixation errors, which are common in medicine and occur when a physician concentrates on only one element of a clinical case without considering other relevant aspects. Here we report a challenging case characterized by the contemporaneous presence of a common disease, asthma, together with a rare respiratory disease, idiopathic tracheal stenosis. Read More

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http://dx.doi.org/10.1186/s12948-017-0060-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296954PMC
February 2017
21 Reads

Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms.

Clin Mol Allergy 2017 3;15. Epub 2017 Feb 3.

Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.

Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Read More

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http://dx.doi.org/10.1186/s12948-017-0059-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290673PMC
February 2017
37 Reads

Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain.

Clin Mol Allergy 2017 6;15. Epub 2017 Jan 6.

ALK-Abelló, S.A, Madrid, Spain.

Background: Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX is the most documented product in terms of safety and efficacy. The objective of this study was to identify the patients' expectations and level of treatment satisfaction, as well as the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX. Read More

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http://dx.doi.org/10.1186/s12948-016-0057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234098PMC
January 2017
23 Reads

Different clinical allergological features of infestation.

Clin Mol Allergy 2016 7;14:18. Epub 2016 Dec 7.

School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy ; Institute of Applied Sciences and Intelligent Systems (ISASI), Messina Unit, Messina, Italy.

The tapeworm () can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tissue eosinophilia and mastocytosis, and with the presence of CD4+ T cells that preferentially produce IL-4, IL-5, and IL-13. Individuals exposed to helminth infections may have allergic inflammatory responses to parasites and parasite antigens. Read More

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http://dx.doi.org/10.1186/s12948-016-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143454PMC
December 2016
15 Reads

Eosinophilic disorders of the gastro-intestinal tract: an update.

Clin Mol Allergy 2016 1;14:17. Epub 2016 Dec 1.

Department of Clinical and Experimental Medicine, University of Parma, via Gramsci, 14, 43100 Parma, Italy.

Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediated pathogenesis. Recent data suggest that, together with the "classic" IgE-response to allergens, also a delayed hypersensitivity mechanism could be involved in the development of eosinophilic disorders. EoE and EGE were studied only in the latest decades and as a consequence accurate data are not yet available, concerning not only pathogenesis, but also epidemiology, treatment and outcomes. Read More

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http://dx.doi.org/10.1186/s12948-016-0055-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131414PMC
December 2016
11 Reads

Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients.

Clin Mol Allergy 2016 8;14:16. Epub 2016 Nov 8.

Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, 50134 Florence, Italy.

Background: CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that chitinases are important in inflammatory processes and tissue remodeling, but their production by human T cells, has never been reported.

Methods: A microarray analysis of gene expression profile was performed on Th17 and classic Th1 cell clones and CHI3L1 was found among the up-regulated genes on Th17 cells. Read More

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http://dx.doi.org/10.1186/s12948-016-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100333PMC
November 2016
31 Reads