Regulation of IgE activity in inhalational tolerance via formation of IgG anti-IgE/IgE immune complexes.
Clin Mol Allergy 2018 18;16:13. Epub 2018 May 18.
1Department of Immunology, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT 06030 USA.
Background: Allergic asthma is an inflammatory disorder of the airways that results from inappropriate production of IgE against harmless, environmental antigens. Sequestration of free IgE using humanized IgG anti-IgE is an effective therapy for asthma and other atopic disorders. However, the status of free IgE in subjects who have naturally developed immune tolerance to inhaled antigens has not been well studied. Read More