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    187 results match your criteria Clinical and Molecular Allergy [Journal]

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    The control of allergic rhinitis in real life: a multicenter cross-sectional Italian study.
    Clin Mol Allergy 2018 2;16. Epub 2018 Feb 2.
    8Allergy and Respiratory Diseases, IRCCS San Martino-IST University of Genoa, Genoa, Italy.
    Background: Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. Read More

    Allergic sensitization to common pets (cats/dogs) according to different possible modalities of exposure: an Italian Multicenter Study.
    Clin Mol Allergy 2018 2;16. Epub 2018 Feb 2.
    34Allergy and Respiratory Diseases, Policlinico San Martino, University of Genoa, Genoa, Italy.
    Background: The query "are there animals at home?" is usually administered for collecting information on anamnesis. This modality to consider exposure to pet allergens constitutes a potential bias in epidemiological studies and in clinical practice. The aim of our study was to evaluate/quantify different modalities of exposure to cat/dog in inducing allergic sensitization. Read More

    A 13-year real-life study on efficacy, safety and biological effects ofvenom immunotherapy.
    Clin Mol Allergy 2018 18;16. Epub 2018 Jan 18.
    1School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation, University of Bari-Aldo Moro, Piazza Giulio Cesare 13, Policlinico, 70124 Bari, Italy.
    Background: venom immunotherapy (VIT) is a clinically effective treatment. However, little is known about its long-term clinical efficacy and biological effects. Several mechanisms have been proposed to account for VIT efficacy, including reduction of specific IgE and induction of allergen-specific IgG, but the overall picture remains elusive. Read More

    Biological clocks: their relevance to immune-allergic diseases.
    Clin Mol Allergy 2018 10;16. Epub 2018 Jan 10.
    1Dipartimento di Medicina e Scienze dell'invecchiamento, Università "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini, 5, 66013 Chieti, Italy.
    The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm. This regulates several activities, including sleep, feeding times, energy metabolism, endocrine and immune functions. Read More

    Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement.
    Clin Mol Allergy 2017 22;15:22. Epub 2017 Dec 22.
    Allergy Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Shariati Square, Mashhad, Iran.
    Background: Spontaneous urticaria is a common allergic skin condition affecting 0.5-1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity.

    Aim: In this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Read More

    Immunosenescence in aging: between immune cells depletion and cytokines up-regulation.
    Clin Mol Allergy 2017 14;15:21. Epub 2017 Dec 14.
    Dermatological Clinic, Department of Biomedical Science and Human Oncology, University of Bari Medical School, Policlinico, Italy.
    Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). Read More

    Tiotropium in asthma: back to the future of anticholinergic treatment.
    Clin Mol Allergy 2017 4;15:20. Epub 2017 Dec 4.
    Department of Biomedicine and Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy.
    Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic agents. Read More

    Selecting optimal second-generation antihistamines for allergic rhinitis and urticaria in Asia.
    Clin Mol Allergy 2017 1;15:19. Epub 2017 Nov 1.
    Personalised Medicine Asthma & Allergy Clinic, Humanitas University, Clinical & Research Hospital, Rozzano, Milan, Italy.
    Background: Allergic diseases are on the rise in many parts of the world, including the Asia-Pacific (APAC) region. Second-generation antihistamines are the first-line treatment option in the management of allergic rhinitis and urticaria. International guidelines describe the management of these conditions; however, clinicians perceive the additional need to tailor treatment according to patient profiles. Read More

    High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi.
    Clin Mol Allergy 2017 1;15:18. Epub 2017 Nov 1.
    R&D, ImmunoDiagnostic Division, Thermo Fisher Scientific, Uppsala, Sweden.
    Background: IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The potential clinical implication of such cross-reactivity is that allergens other than the known sensitizer can cause allergic symptoms. Read More

    Tolerated drugs in subjects with severe cutaneous adverse reactions (SCARs) induced by anticonvulsants and review of the literature.
    Clin Mol Allergy 2017 4;15:16. Epub 2017 Oct 4.
    Department of Allergology and Immunology, Ospedale Metropolitano Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy.
    Background: Anticonvulsant hypersensitivity syndrome represents a rare but potentially fatal kind of adverse drug reaction. This clinical picture often hampers the flexibility with which alternative anticonvulsants or even other classes of drugs are prescribed in these patients, negatively affecting the efficacy of treatment and the course of the disease. The aim of this study was to analyse a group of six patients with severe cutaneous drug reactions induced by anticonvulsants and to report which alternative antiepileptic drugs and which drugs of other classes were tolerated. Read More

    A survey on the perception of allergy specialists about the reimbursed grass pollen tablets for seasonal allergic rhinitis in Italy.
    Clin Mol Allergy 2017 15;15:15. Epub 2017 Aug 15.
    Allergy and Pneumology Departmental Unit, Fondazione Poliambulanza Hospital, Brescia, Italy.
    Background: Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit its prescription. In 2015, the 5-grass pollen tablets was authorized by the European Medicine Agency to treat grass-pollen induced rhinitis and was approved in Italy for full reimbursement. Read More

    Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature.
    Clin Mol Allergy 2017 15;15:14. Epub 2017 Jun 15.
    AN-Najah National University Teaching Hospital, Asira, Nablus, West bank Palestine.
    Background: Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity reaction. This reaction can be ranged from mild cutaneous rash to anticonvulsant hypersensitivity syndrome (AHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) that includes fever, rash, eosinophilia and involvement of multiple internal organs. Read More

    Preventive actions of allergen immunotherapy: the facts and the effects in search of evidence.
    Clin Mol Allergy 2017 15;15:13. Epub 2017 Jun 15.
    Medicine and Surgery Department, University of Parma, via Gramsci n.14, 43126 Parma, Italy.
    Allergen immunotherapy (AIT) is the only treatment that works on the causes of allergy. Available AIT nowadays are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) for allergic rhinitis and asthma, while for allergy tovenom only subcutaneous route is recommended. A bulk of trials and meta-analyses demonstrated that efficacy and safety of AIT in decreasing allergic clinical symptoms and use of rescue medications, while its preventive capacity is yet under investigation. Read More

    Association between HMGB1 and asthma: a literature review.
    Clin Mol Allergy 2017 14;15:12. Epub 2017 Jun 14.
    School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Background: Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation.

    Objective: This literature review aims to analyse advances on HMGB1 role, employment and potential diagnostic application in asthma. Read More

    The soft computing-based approach to investigate allergic diseases: a systematic review.
    Clin Mol Allergy 2017 13;15:10. Epub 2017 Apr 13.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy.
    Background: Early recognition of inflammatory markers and their relation to asthma, adverse drug reactions, allergic rhinitis, atopic dermatitis and other allergic diseases is an important goal in allergy. The vast majority of studies in the literature are based on classic statistical methods; however, developments in computational techniques such as soft computing-based approaches hold new promise in this field.

    Objective: The aim of this manuscript is to systematically review the main soft computing-based techniques such as artificial neural networks, support vector machines, bayesian networks and fuzzy logic to investigate their performances in the field of allergic diseases. Read More

    SANI-Severe Asthma Network in Italy: a way forward to monitor severe asthma.
    Clin Mol Allergy 2017 10;15. Epub 2017 Apr 10.
    Allergy & Respiratory Disease, DIMI-University of Genova, Largo Rosanna Benzi, 10, 16132 Genova, Italy.
    Even if severe asthma (SA) accounts for 5-10% of all cases of the disease, it is currently a crucial unmet need, owing its difficult clinical management and its high social costs. For this reason several networks, focused on SA have been organized in some countries, in order to select these patients, to recognize their clinical features, to evaluate their adherence, to classify their biological/clinical phenotypes, to identify their eligibility to the new biologic therapies and to quantify the costs of the disease. Aim of the present paper is to describe the ongoing Italian Severe Asthma Network (SANI). Read More

    Hypersensitivity reactions due to black henna tattoos and their components: are the clinical pictures related to the immune pathomechanism?
    Clin Mol Allergy 2017 10;15. Epub 2017 Apr 10.
    Section of Allergy and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.
    Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various clinical aspects are described in literature due to PPD associated to henna tattoo and these manifestations are likely correlated with the immunological and dermatological pathomechanisms involved. Henna is the Persian name of the plantFam. Read More

    Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study.
    Clin Mol Allergy 2017 3;15. Epub 2017 Apr 3.
    Children's Hospital for Lung Diseases and Tuberculosis, Medical Center "Dr. Dragiša Mišović", Belgrade, Pilota Mihajla Tepica 1, 11000 Belgrade, Serbia.
    Background: Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy).

    Methods: 7-18 years old children with allergic asthma and rhinitis were enrolled and addressed to the active (AIT plus pharmacological treatment) or control (standard pharmacological treatment only) group. Read More

    Hypersensitivity pneumonitis: a complex lung disease.
    Clin Mol Allergy 2017 7;15. Epub 2017 Mar 7.
    Division of Sub Acute Care, Sesto San Giovanni Hospital, ASST Nord Milano, Sesto San Giovanni, Italy.
    Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Such reaction is secondary to a repeated and prolonged inhalation of different types of organic dusts or other substances to which the patient is sensitized and hyper responsive, primarily consisting of organic dusts of animal or vegetable origin, more rarely from chemicals. The prevalence of HP is difficult to evaluate because of uncertainties in detection and misdiagnosis and lacking of widely accepted diagnostic criteria, and varies considerably depending on disease definition, diagnostic methods, exposure modalities, geographical conditions, agricultural and industrial practices, and host risk factors. Read More

    Pharmacoeconomics of sublingual immunotherapy with the 5-grass pollen tablets for seasonal allergic rhinitis.
    Clin Mol Allergy 2017 7;15. Epub 2017 Mar 7.
    Department of Clinical & Experimental Medicine, University of Parma, Via Gramsci 14, Parma, Italy.
    Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This particularly concerns allergen immunotherapy (AIT), that, based on its immunological action on the causes of allergy, extends its benefit also after discontinuation of the treatment. Read More

    Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.
    Clin Mol Allergy 2017 3;15. Epub 2017 Mar 3.
    Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
    Background: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.

    Methods: Three-hundred and four children (median age 13. Read More

    Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error.
    Clin Mol Allergy 2017 8;15. Epub 2017 Feb 8.
    Dipartimento Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
    Background: Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may be influenced by fixation errors, which are common in medicine and occur when a physician concentrates on only one element of a clinical case without considering other relevant aspects. Here we report a challenging case characterized by the contemporaneous presence of a common disease, asthma, together with a rare respiratory disease, idiopathic tracheal stenosis. Read More

    Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms.
    Clin Mol Allergy 2017 3;15. Epub 2017 Feb 3.
    Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.
    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Read More

    Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain.
    Clin Mol Allergy 2017 6;15. Epub 2017 Jan 6.
    ALK-Abelló, S.A, Madrid, Spain.
    Background: Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAXis the most documented product in terms of safety and efficacy. The objective of this study was to identify the patients' expectations and level of treatment satisfaction, as well as the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX. Read More

    Different clinical allergological features ofinfestation.
    Clin Mol Allergy 2016 7;14:18. Epub 2016 Dec 7.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy ; Institute of Applied Sciences and Intelligent Systems (ISASI), Messina Unit, Messina, Italy.
    The tapeworm()can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tissue eosinophilia and mastocytosis, and with the presence of CD4+ T cells that preferentially produce IL-4, IL-5, and IL-13. Individuals exposed to helminth infections may have allergic inflammatory responses to parasites and parasite antigens. Read More

    Eosinophilic disorders of the gastro-intestinal tract: an update.
    Clin Mol Allergy 2016 1;14:17. Epub 2016 Dec 1.
    Department of Clinical and Experimental Medicine, University of Parma, via Gramsci, 14, 43100 Parma, Italy.
    Eosinophilic diseases of the gastrointestinal tract, including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), are rare chronic pathologies of the digestive system, with an immuno-mediated pathogenesis. Recent data suggest that, together with the "classic" IgE-response to allergens, also a delayed hypersensitivity mechanism could be involved in the development of eosinophilic disorders. EoE and EGE were studied only in the latest decades and as a consequence accurate data are not yet available, concerning not only pathogenesis, but also epidemiology, treatment and outcomes. Read More

    Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients.
    Clin Mol Allergy 2016 8;14:16. Epub 2016 Nov 8.
    Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, 50134 Florence, Italy.
    Background: CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that chitinases are important in inflammatory processes and tissue remodeling, but their production by human T cells, has never been reported.

    Methods: A microarray analysis of gene expression profile was performed on Th17 and classic Th1 cell clones and CHI3L1 was found among the up-regulated genes on Th17 cells. Read More

    HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4.
    Clin Mol Allergy 2016 1;14:15. Epub 2016 Nov 1.
    Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
    Background: The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal environment for viral replication, e.g. Read More

    Dose-dependence of protection from systemic reactions to venom immunotherapy by omalizumab.
    Clin Mol Allergy 2016 24;14:14. Epub 2016 Oct 24.
    Allergy Unit, Sant'Anna Hospital, ASST Lariana, Via Napoleona 60, 22100 Como, Italy.
    Background: Systemic reactions (SR) to venom immunotherapy (VIT) are rare but may occur, with a rate significantly higher for honeybee than for vespid VIT. In patients with repeated SRs to VIT it is difficult to reach the maintenance dose of venom and pre-treatment with omalizumab is indicated, as shown by some studies reporting its preventative capacity, when antihistamines and corticosteroids are ineffective.

    Case Presentation: We present the case of a 47 years old woman allergic to bee venom who experienced two severe SRs after bee stings and several SRs to VIT with bee venom. Read More

    Mastocytosis and systemic sclerosis: a clinical association.
    Clin Mol Allergy 2016 11;14:13. Epub 2016 Oct 11.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy ; Institute of Applied Sciences and Intelligent Systems (ISASI), Pozzuoli, NA Italy.
    Background: Systemic sclerosis (SSc) is a complex autoimmune disease characterized by vascular alterations and autoimmune activation leading to widespread organ fibrosis. At the early stage of disease when organ involvement and extent of disease are emerging, mast cells may have some role, as implied by both symptoms and histologic evidence.

    Case Presentation: A female patient diagnosed with cutaneous mastocytosis experienced the onset of systemic sclerosis after 15 years followed by the switch of mastocytosis to the systemic phenotype. Read More

    Burden of allergic respiratory disease: a systematic review.
    Clin Mol Allergy 2016 28;14:12. Epub 2016 Sep 28.
    MAPI, London, UK.
    This meta-analysis compared the health-related quality of life (HRQL) of patients with allergic rhinitis (AR) and/or allergic asthma (AA) caused by perennial house dust mite (HDM) versus AR and/or AA caused by seasonal pollen allergy. Following a systematic search, the identified studies used the disease-specific rhinitis quality of life questionnaire or generic instruments (SF-36 and SF-12). Summary estimates obtained by meta-analysis showed that HRQL in patients with perennial HDM allergy was significantly worse than that of patients with seasonal pollen allergy, when measured by both disease-specific and generic HRQL instruments, and was reflected by an impact on both physical and mental health. Read More

    How pregnancy can affect autoimmune diseases progression?
    Clin Mol Allergy 2016 15;14:11. Epub 2016 Sep 15.
    Center of Excellence for Research, Transfer and High Education DENOTHE of the University of Florence, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Autoimmune disorders are characterized by tissue damage, caused by self-reactivity of different effectors mechanisms of the immune system, namely antibodies and T cells. Their occurrence may be associated with genetic and/or environmental predisposition and to some extent, have implications for fertility and obstetrics. The relationship between autoimmunity and reproduction is bidirectional. Read More

    Unmet diagnostic needs in contact oral mucosal allergies.
    Clin Mol Allergy 2016 1;14(1):10. Epub 2016 Sep 1.
    Section of Allergology and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.
    The oral mucosa including the lips is constantly exposed to several noxious stimuli, irritants and allergens. However, oral contact pathologies are not frequently seen because of the relative resistance of the oral mucosa to irritant agents and allergens due to anatomical and physiological factors. The spectrum of signs and symptoms of oral contact allergies (OCA) is broad and a large number of condition can be the clinical expression of OCA such as allergic contact stomatitis, allergic contact cheilitis, geographic tongue, oral lichenoid reactions, burning mouth syndrome. Read More

    Drug induced exfoliative dermatitis: state of the art.
    Clin Mol Allergy 2016 22;14. Epub 2016 Aug 22.
    Department of Allergy and Clinical Immunology, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy ; Vita-Salute San Raffaele University, Milan, Italy.
    Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Read More

    Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE.
    Clin Mol Allergy 2016 19;14. Epub 2016 Aug 19.
    Division of Asthma, Allergy and Lung Biology, Guy's and St. Thomas' NHS Foundation Trust, London, SE1 7EH UK.
    Background: Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarray assays. The aim of this pilot study was to assess current tests and the ISAC sIgE-112 system in the diagnosis of food and aeroallergen allergy. Read More

    Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.
    Clin Mol Allergy 2016 5;14. Epub 2016 Aug 5.
    Unit of Allergy and Immunotoxicology, Center of Ageing Science, "Università G. d'Annunzio" Foundation, Chieti, Italy ; Department of Medicine and Ageing Science (DMSI), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
    Background: Airborne allergens can induce an immunological chronic disease characterized by airway hyper responsiveness and inflammation, mediated by exaggerated Th2 immune response. Allergen-specific immunotherapy (AIT) is effective for treating this condition because it is able to modify its natural course by opposing the underlying pathogenic mechanisms and determining immune suppression, immune deviation and tolerance. The rational for the present study was to investigate the possibility of improving allergoid-based IT in terms of efficacy and safety. Read More

    Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay.
    Clin Mol Allergy 2016 15;14. Epub 2016 Jul 15.
    Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Hospital, University of Turin, piazza del donatore di Sangue 3, 10054 Turin, Italy.
    Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or pregnancy loss. The currently used classification criteria were updated in the international consensus held in Sidney in 2005. Vascular events seem to result of local procoagulative alterations upon triggers influence (the so called "second-hit theory"), while placental thrombosis and complement activation seem to lead to pregnancy morbidity. Read More

    Appropriateness in allergic respiratory diseases health care in Italy: definitions and organizational aspects.
    Clin Mol Allergy 2016 19;14. Epub 2016 Apr 19.
    Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.
    In a historical period in which sustainability of the National Health Service is mandatory because of the international economical situation, the limited available resources at national level and the tendency of passing from a "population medicine" model towards the concept of "individualized medicine", the debate on appropriateness of medical and surgical procedures is of central importance. The choosing wisely campaign, started in United States in 2012 and then spread all over the world, tries to summarize which are the most inappropriate procedures for each medical and surgical speciality; as far as allergic respiratory diseases, the most relevant Italian societies and the American Academy defined the allergological procedures with the highest probability of inappropriateness. In Italy, a recent decree of the Ministry of Health defined a list of more than 200 procedures that will be considered as inappropriate in certain conditions; many of these procedures concern allergology, including allergic respiratory diseases. Read More

    Quality of life in patients with food allergy.
    Clin Mol Allergy 2016 17;14. Epub 2016 Feb 17.
    Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias. Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Carretera de Alcalá-Meco s/n, 28085 Alcalá de Henares, Madrid, Spain.
    Food allergy has increased in developed countries and can have a dramatic effect on quality of life, so as to provoke fatal reactions. We aimed to outline the socioeconomic impact that food allergy exerts in this kind of patients by performing a complete review of the literature and also describing the factors that may influence, to a greater extent, the quality of life of patients with food allergy and analyzing the different questionnaires available. Hitherto, strict avoidance of the culprit food(s) and use of emergency medications are the pillars to manage this condition. Read More

    Comparing the ability of molecular diagnosis and CAP-inhibition in identifying the really causative venom in patients with positive tests to Vespula and Polistes species.
    Clin Mol Allergy 2016 8;14. Epub 2016 Feb 8.
    Allergy/Pulmonary Rehabilitation, ICP Hospital, Via Bignami 1, 20100 Milan, Italy.
    Background: Cross-reactivity among Hymenoptera venoms is an important issue when prescribing venom immunotherapy (VIT). Using all venoms eliciting a positive response results in treatment excess and unjustified cost increase. The first in vitro method that helped to identify the really causative venom was RAST-inhibition, but in latest years also molecular allergy (MA) diagnostics, that detects specific sIgE to single venom allergens, was introduced. Read More

    Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.
    Clin Mol Allergy 2016 25;14. Epub 2016 Jan 25.
    Clinical Chemistry and Microbiology Laboratory, IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20164 Milan, Italy.
    Background: Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria in worsening the symptomatology of AD and psoriasis. In the present study we evaluated the skin microbiota composition in accurately selected subjects affected by (AD) and psoriasis. Read More

    Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4.
    Clin Mol Allergy 2016 21;14. Epub 2016 Jan 21.
    Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Background: Trophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. Read More

    Erratum to: Guidelines for the use and interpretation of diagnostic methods in adult food allergy.
    Clin Mol Allergy 2015 21;13:31. Epub 2015 Dec 21.
    Unit of Allergy and Immunotoxicology, CeSi, "G. d'Annunzio" University Foundation, Chieti, Italy.
    [This corrects the article DOI: 10.1186/s12948-015-0033-9.]. Read More

    Determinants of venom-specific IgE antibody concentration during long-term wasp venom immunotherapy.
    Clin Mol Allergy 2015 15;13:29. Epub 2015 Dec 15.
    Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.
    Background: Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE changes to decide about VIT cessation. We assessed IgE changes during a 5-year VIT, in patients stung and protected within the first 3 years (SP 0-3) or in the last 2 years (SP 3-5), and in patients not stung (NoS), to evaluate possible correlations between IgE changes and clinical protection.

    Methods: Yellow jacket venom (YJV)-allergic patients who completed 5 years of VIT were retrospectively evaluated. Read More

    Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients.
    Clin Mol Allergy 2015 2;13:30. Epub 2015 Dec 2.
    Clinical Pathology, Allergy Unit, Buccheri La Ferla Hospital, Palermo, Italy.
    Background: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy.

    Methods: 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Read More

    Choosing wisely in Allergology: a Slow Medicine approach to the discipline promoted by the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC).
    Clin Mol Allergy 2015 20;13:28. Epub 2015 Nov 20.
    Allergy and Respiratory Diseases Clinic, DIMI-Department of Internal Medicine, IRCCS AOU S.Martino-IST, Genoa, Italy.
    Background: One of the main problem health care systems are facis is the mis-use and over-use of medical resources (including useless exams, surgical interventions, medical treatments, screening procedures…) which may lead to high health care related costs without increased patients' benefit and possible harm to the patients themselves. The "Choosing wisely" campaign, in Italy denominated "Doing more does not mean doing better", tries to educate doctors and citizens at a correct use of medical resources.

    Methods: the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC) adhered to the "Doing more does not mean doing better" campaing and made a list of the 5 allergological procedures with the highest evidence of inappropriateness. Read More

    Asthma under/misdiagnosis in primary care setting: an observational community-based study in Italy.
    Clin Mol Allergy 2015 16;13:26. Epub 2015 Nov 16.
    Dipartimento di Scienze Mediche, Sezione di Medicina Interna e Cardiorespiratoria, Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo-Correlate (CEMICEF, formerly termed Centro), Università di Ferrara, Ferrara, Italy.
    Background: Published data suggest that asthma is significantly under/misdiagnosed. The present community-based study performed in Italy aims at investigating the level of asthma under/misdiagnosis among patients referring to the General Practitioner (GP) for respiratory symptoms and undergoing Inhaled corticosteroids.

    Methods: A sub-analysis of a previously published observational cross-sectional study has been provided. Read More

    MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations.
    Clin Mol Allergy 2015 9;13:22. Epub 2015 Nov 9.
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Clinically amyopathic dermatomyositis (CADM), described almost 50 years ago, is defined on the basis of still not validated criteria and characterized by skin findings almost without muscle weakness. Autoantibodies directed against the cytosolic pathogen sensor MDA5 (CADM 140) can mark this subtype of dermatomyositis which has been reported to associate, in particular ethnic groups, with severe progressive interstitial lung disease, poor prognosis and an hyperferritinemic status resembling hemophagocytic-like syndromes. MDA5 may be relevant in that Interferon-signature claimed to characterize inflammatory myopathies and dermatomyosits itself, but its role is not clear. Read More

    Risk of anaphylaxis in patients with large local reactions to hymenoptera stings: a retrospective and prospective study.
    Clin Mol Allergy 2015 9;13:21. Epub 2015 Nov 9.
    Allergy/Pulmonary Rehabilitation, ICP Hospital, via Bignami 1, 20126 Milan, Italy.
    Background: In the few studies available, the risk of developing systemic reactions (SR) to hymenoptera stings in patients with previous large local reactions (LLRs) to stings ranges from 0 to 7 %. We evaluated both retrospectively and prospectively the risk of SRs in patients with LLRs to stings.

    Methods: An overall number of 477 patients, 396 with an SR as the first manifestation of allergy and 81 with a history of only LLRs after hymenoptera stings, were included in the study. Read More

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