6,599 results match your criteria Clinical and Experimental Pharmacology and Physiology[Journal]


An anti-asthmatic activity of Natural Toll like receptor-4 antagonist in OVA-LPS induced asthmatic rats.

Clin Exp Pharmacol Physiol 2018 Jun 23. Epub 2018 Jun 23.

Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, 380009.

TLR4 is a key component of innate immune system and activation of TLR4 signaling has the significant role in the pathogenesis of asthma. Therefore, our objective was to identify the natural TLR4 antagonist and evaluate its activity in experimentally induced asthma. Soya lecithin origin phosphatidylcholine (Soya PC) was identified as a natural TLR4 antagonist by the computational study. Read More

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Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: comparison with captopril.

Clin Exp Pharmacol Physiol 2018 Jun 23. Epub 2018 Jun 23.

Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi Province, China.

The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals were divided into: control lean Zucker rats, ZDF rats, ZDF rats orally treated with nebivolol (10 mg/kg), atenolol (100 mg/kg) or captopril (40 mg/kg) for 6 months. Systolic blood pressure (SBP), blood glucose, kidney structure and function, plasma and kidney levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA), and oxidant status were evaluated. Read More

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Diabetes-induced alterations in urothelium function:enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder.

Clin Exp Pharmacol Physiol 2018 Jun 23. Epub 2018 Jun 23.

Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Queensland, Australia.

Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining (urothelium). Bladder compliance and intraluminal release of urothelial mediators (ATP and ACh) in response to distension was investigated in whole bladders isolated from 2 and 12-week streptozotocin (STZ)-diabetic rats. Read More

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Increases in placental nitric oxide, but not nitric oxide-mediated relaxation, underlie the improvement in placental efficiency and antihypertensive effects of hydrogen sulphide donor in hypertensive pregnancy.

Clin Exp Pharmacol Physiol 2018 Jun 21. Epub 2018 Jun 21.

Department of Pharmacology, Biosciences Institute of Botucatu São Paulo State University - UNESP, Botucatu, Sao Paulo, Brazil.

Dysregulation of hydrogen sulphide (H S) producing enzymes has been related to hypertensive pregnancy and H S donor, sodium hydrosulphide (NaHS) exerts antihypertensive effects, modulates angiogenic factors production and acts as an antioxidant. Moreover, reduction in nitric oxide (NO) bioavailability is related to hypertensive pregnancy and H S may interact with NO, modulating its production. We aimed to investigate the NaHS effects in hypertension-in-pregnancy and also in feto-placental parameters. Read More

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7,8-Dihydroxyflavone Enhances Cholinergic Contraction of Rat Gastric Smooth Muscle via Augmenting Muscarinic M3 Receptor Expression.

Clin Exp Pharmacol Physiol 2018 Jun 21. Epub 2018 Jun 21.

Department of Clinical Nutrition, Affiliated Hospital, Qingdao University, Qingdao, China266003.

Although 7,8-dihydroxyflavone (7,8-DHF), a synthetic agonist specific for TrkB, has been reported to promote intestinal dynamics, the molecular mechanisms behind its effects are not well known. In this study, we explored how 7,8-DHF affected the carbachol (CCh)-induced contraction of rat gastric muscle by way of measuring the contractile tension of muscular strips. We found that although 7,8-DHF did not directly cause contraction of gastric muscle, it enhanced the CCh-induced contractions, but not substance P- or high K -induced contractions. Read More

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Inducible nitric oxide synthase inhibitor 1400W increases Na ,K -ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells.

Clin Exp Pharmacol Physiol 2018 Jun 20. Epub 2018 Jun 20.

Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.

Nitric oxide (NO) has been shown to play an important role in renal physiology and pathophysiology partly through its influence on various transport systems in the kidney proximal tubule. The role of NO in the kidney dysfunction associated with the lysosomal storage disorder, cystinosis, is largely unknown. In the present study, the effects of iNOS-specific inhibitor, 1400W, on Na ,K -ATPase activity and expression, mitochondrial integrity and function, nutrient metabolism, and apoptosis were investigated in Ctns null proximal tubular epithelial cells (PTECs). Read More

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Effects of muscarinic acetylcholine receptor stimulation on the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.

Clin Exp Pharmacol Physiol 2018 Jun 19. Epub 2018 Jun 19.

Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan.

Muscarinic acetylcholine receptors (mAchRs), which are expressed in various embryonic cells, may regulate neuronal differentiation. In the present study, we examined the effects of mAchR stimulation on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells (NPCs). Mouse iPS cells were cultured on ultra-low attachment dishes to induce embryoid body (EB) formation. Read More

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Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity.

Clin Exp Pharmacol Physiol 2018 Jun 19. Epub 2018 Jun 19.

Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, 215003, China.

Functional deficiency of ADAMTS13 causally assists in the pathology of thrombotic thrombocytopenic purpura (TTP). Previous study showed that WXXW motif is very important to the enzymatic activity of ADAMTS13. However, the functional role for a single amino acid residue within WXXW motif is still undetermined. Read More

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The long non coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy.

Clin Exp Pharmacol Physiol 2018 Jun 19. Epub 2018 Jun 19.

Department of Cardiology, Heraklion University Hospital, Crete, Greece.

Long non-coding RNAs (lncRNAs) participate in the modulation of cardiac hypertrophy and they represent potential therapeutic targets in cardiovascular disease. We investigated the expression profiles of selected lncRNAs in peripheral blood mononuclear cells of patients with essential hypertension in relation to left ventricular hypertrophy. We assessed the expression levels of the lncRNAs MHRT, FENDRR and CARMEN using real-time reverse transcription polymerase chain reaction. Read More

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Relationships between meconium concentrations of acute phase proteins.

Clin Exp Pharmacol Physiol 2018 Jun 16. Epub 2018 Jun 16.

Institute of Mother and Child, Reproductive Health Department, Warsaw, Poland.

Meconium concentrations of naturally accumulated ceruloplasmin (CER), lactoferrin (LF), and neutrophil gelatinase-associated lipocalin (NGAL) and their relationships considered as a panel of acute phase proteins could be used for the assessment of fetal homeostasis. CER, LF and NGAL concentrations were measured using ELISA kits in meconium portions (n=80) collected from 19 healthy neonates. The coefficients of variation (CV) of the meconium LF (1. Read More

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Macrophages in patients with recurrent endometrial polyps could exacerbate Th17 responses.

Clin Exp Pharmacol Physiol 2018 Jun 16. Epub 2018 Jun 16.

Department of Gynaecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. Read More

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Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients.

Clin Exp Pharmacol Physiol 2018 Jun 15. Epub 2018 Jun 15.

Department of Surgery, Shandong Qianfoshan Hospital, ShandongUniversity, Jinan, Shandong, China.

Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3  Treg accumulation in the tumor was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients. Read More

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The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation.

Clin Exp Pharmacol Physiol 2018 Jun 8. Epub 2018 Jun 8.

Department of Pharmacology, Medical College, Jinan University, Guangzhou, China.

Zoledronic acid (ZA), a third-generation bisphosphonate, has been applied for treatment of bone metastases caused by malignant tumors. Recent studies have found its anti-cancer effects on various tumor cells. One of the mechanisms of anti-cancer effects of ZA is induction of apoptosis. Read More

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June 2018
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Identification and Evaluation of Two Circulating microRNAs for Non-small Cell Lung Cancer Diagnosis.

Clin Exp Pharmacol Physiol 2018 Jun 4. Epub 2018 Jun 4.

Department of Radiology, Changzhou NO.2 People's Hospital, Changzhou, Jiangsu, 213000, China.

The circulating miRNAs are dysregulated in Non-small Cell Lung Cancer (NSCLC) and have great promising for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients (p<0. Read More

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June 2018
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Cytochrome P450 genotype-guided drug therapies: an update on current states.

Clin Exp Pharmacol Physiol 2018 Jun 2. Epub 2018 Jun 2.

School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.

Over the past two decades, knowledge of the role and clinical value of pharmacogenetic markers has expanded so that individualized pre-emptive therapy based on genetic background of patients could be within reach for clinical implementation. This is evidenced from the frequent updating of drug labels that incorporates pharmacogenetic information (where compelling data become available) by the regulatory agencies (such as FDA), and the periodical publication of guidelines of specific therapeutic recommendations based on the results of pharmacogenetic tests by the pharmacogenetics working groups or consortiums of professional bodies. Clinical relevance of the cytochrome P450 (CYP) polymorphism related to dose, effectiveness and/or toxicity of key drugs are presented in this review, including that of warfarin, clopidogrel, tricyclic antidepressants, and proton pump inhibitors. Read More

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June 2018
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Gene expression dynamics following mithramycin treatment: a possible model for post-chemotherapy cognitive impairment.

Clin Exp Pharmacol Physiol 2018 May 30. Epub 2018 May 30.

Laboratory of Psychobiology Department of Psychiatry, Rambam Medical Center.

Chemotherapy-induced cognitive changes is a major burden on a substantial number of cancer survivors. The mechanism of this sequel is unknown. In this study, we followed long-term effects of early in life mithramycin (MTR) treatment on behavior and on the normal course of alterations of gene expression in brain. Read More

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May 2018
1 Read

Chronic moderate alcohol consumption relieves high-fat high-cholesterol diet-induced liver fibrosis in a rat model.

Clin Exp Pharmacol Physiol 2018 May 30. Epub 2018 May 30.

Department of Elderly Gastroenterology, the First Hospital of China Medical University, Shenyang, 110001, China.

Nonalcoholic fatty liver disease is a worldwide health issue and chronic alcohol consumption may have different effects on this disease. This study explored the role of chronic moderate alcohol consumption on high-fat high-cholesterol (HFHC) diet-induced liver fibrosis in a rodent model. Male Sprague-Dawley rats were divided into five groups: standard chow group, standard chow plus Er Guo Tou (EGT, a Chinese spirits made from fermented cereals) group, HFHC group, HFHC plus EGT group, and HFHC plus pure ethanol group. Read More

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May 2018
2 Reads

In Vivo Profiling of Four Centrally Administered Opioids for Antinociception, Constipation and Respiratory Depression: Between Colony Differences in Sprague Dawley Rats.

Authors:
A Kuo M T Smith

Clin Exp Pharmacol Physiol 2018 May 22. Epub 2018 May 22.

Centre for Integrated Preclinical Drug Development, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Outbred rodent stocks including Sprague Dawley rats, are known for their genetic diversity and so they are often used to develop animal models of human disease. Although between-colony differences in pharmaco-behavioural studies have been published previously, a direct head-to-head comparison study, whereby all research was performed in the same laboratory by the same experimenter utilising the supraspinal route of drug administration in the same strain of rat, is lacking. Herein, we report our head-to-head comparison study, involving assessment of antinociception, constipation and respiratory depression evoked by single bolus intracerebroventricular (ICV) doses of morphine, buprenorphine, DPDPE and U69,593 using male Sprague Dawley rats sourced from a different breeding colony (BC2) from that (BC1) used by us previously. Read More

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May 2018
5 Reads

Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.

Clin Exp Pharmacol Physiol 2018 May 21. Epub 2018 May 21.

Department of Oncology, Tangdu Hospital, The Fourth Military Medical University, Shaanxi, Xi'an, 710038, China.

Gastric cancer accounts for a sizeable proportion of global cancer mortality with high morbidity and poor prognosis. Kinesin superfamily proteins (KIFs) are microtubule-dependent motor proteins that function as oncogenes in cancer cells, it has been discovered in recent years. Kinesin family member 2a (KIF2A), a member of KIFs, has received attention for its role in carcinogenesis and its prognostic value in several human cancers such as breast cancer, colorectal cancer, and squamous cell carcinoma. Read More

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Associations of candidate gene polymorphisms with poor responsiveness to aspirin: a meta-analysis.

Clin Exp Pharmacol Physiol 2018 May 21. Epub 2018 May 21.

Department of cardiovascular surgery, The second affiliated hospital of Nanchang university, 330006, Nanchang, Jiangxi, China.

Recently, the roles of gene polymorphisms in poor responsiveness to aspirin were extensively investigated, with conflicting results. Therefore, we performed this meta-analysis to better assess the relationship between candidate genetic variants and poor responsiveness to aspirin. Eligible articles were searched in PubMed, Medline, Embase and CNKI. Read More

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May 2018
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Comparative Analgesic Efficacy of Pregabalin Administered According to Either a Prevention Protocol or an Intervention Protocol in Rats with Cisplatin-induced Peripheral Neuropathy.

Clin Exp Pharmacol Physiol 2018 May 21. Epub 2018 May 21.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Chemotherapy-induced peripheral neuropathy (CIPN) is a type of peripheral neuropathic pain that may be dose-limiting in patients administered potentially curative cancer chemotherapy dosing regimens. In cancer survivors, persistent CIPN adversely affects patient quality of life and so adjuvant drugs (anticonvulsants e.g. Read More

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May 2018
2 Reads

Cyanidin-3-glucoside inhibits inflammatory activities in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis.

Authors:
Yan Sun Lingling Li

Clin Exp Pharmacol Physiol 2018 May 19. Epub 2018 May 19.

Medical Record Statistical Room, Daqing Oilfield General Hospital, Daqing, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint tissue inflammation. Cyanidin-3-glucoside (C3G) is a major component in the flavonoid family and has shown anti-inflammatory, anti-oxidant and anti-tumour activity. In this study, we investigated the effects of C3G on lipopolysaccharides (LPS)-induced inflammation on human rheumatoid fibroblast-like synoviocytes (FLS) and on collagen-induced arthritis (CIA) mice model. Read More

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May 2018
1 Read

Nucleocytoplasmic shuttling: the ins and outs of quantitative imaging.

Clin Exp Pharmacol Physiol 2018 May 17. Epub 2018 May 17.

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Nucleocytoplasmic protein shuttling is integral to the transmission of signals between the nucleus and the cytoplasm. The nuclear/cytoplasmic distribution of proteins of interest can be determined via fluorescence microscopy, following labelling of the target protein with fluorophore-conjugated antibodies (immunofluorescence) or by tagging the target protein with an autofluorescent protein, such as green fluorescent protein (GFP). The latter enables live cell imaging, a powerful approach that precludes many of the artefacts associated with indirect immunofluorescence in fixed cells. Read More

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May 2018
1 Read

The endocannabinoid-alcohol crosstalk: recent advances on a bi-faceted target.

Clin Exp Pharmacol Physiol 2018 May 16. Epub 2018 May 16.

Department of Sciences for Health Promotion and Mother and Child Care "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.

Increasing evidence focuses on the endocannabinoid system as a relevant player in the induction of aberrant synaptic plasticity and related addictive phenotype following chronic excessive alcohol drinking. Besides, the endocannabinoid system is implicated in the pathogenesis of alcoholic liver disease. Interestingly, whereas the involvement of CB1 cannabinoid receptors in alcohol rewarding properties is established, the central and peripheral action of CB2 cannabinoid signalling is still to be elucidated. Read More

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May 2018
1 Read

Icotinib enhances lung cancer cell radiosensitivity in vitro and in vivo by inhibiting MAPK/ERK and AKT activation.

Clin Exp Pharmacol Physiol 2018 May 16. Epub 2018 May 16.

Department of Radiation Oncology, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing, China.

Icotinib hydrochloride is a small epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that was developed by Chinese scientists. While clinical trials have revealed its efficacy in the treatment of lung cancer, very little is known about its role in enhancing radiosensitivity. In this study, we investigated the effectiveness of Icotinib in enhancing lung cancer cell radiosensitivity and have detailed its underlying molecular mechanism. Read More

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May 2018
5 Reads

Utility of electrical velocimetry-based noninvasive stroke volume variation in predicting fluid responsiveness under different ventilation modes in anaesthetized dogs.

Clin Exp Pharmacol Physiol 2018 May 16. Epub 2018 May 16.

Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We evaluated the utility of noninvasive stroke volume variation (SVV) as a functional haemodynamic predictor for fluid responsiveness under different ventilation modes [assist control (A/C), synchronized intermittent mandatory ventilation (SIMV), and continuous positive airway pressure (CPAP)] in 45 anaesthetized dogs, using an electrical velocimetry device. Receiver operating curve analysis confirmed the best predictive value during SVV (12.5% of cut-off value; 75% sensitivity and 86% specificity) followed by SVV (13. Read More

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Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus.

Clin Exp Pharmacol Physiol 2018 May 14. Epub 2018 May 14.

Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Osaka, Japan.

Depression is one of the most common psychiatric diseases and is commonly comorbid with type 1 or 2 diabetes mellitus (DM). However, the pathophysiology underlying the depressive state in DM remains poorly understood. Animal models are useful tools to investigate the association between depression and DM. Read More

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May 2018
4 Reads

Synthesis, characterization and electrochemistry studies of iron(III) complex with curcumin ligand.

Clin Exp Pharmacol Physiol 2018 May 11. Epub 2018 May 11.

Department of Biochemistry, Faculty of Medicine, Cukurova University, Adana, Turkey.

Iron overload is a serious clinical condition for humans and is a key target in drug development. The aim of this study was to investigate the coordination of iron(III) ions with curcumin ligand that may be used in the treatment of iron overload. Iron(III) complex of curcumin was synthesized and structurally characterized in its solid and solution state by FT-IR, UV-Vis, elemental analysis, and magnetic susceptibility. Read More

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May 2018
3 Reads

Exploring novel pharmacotherapeutic applications and repurposing potential of sodium glucose CoTransporter 2 inhibitors.

Clin Exp Pharmacol Physiol 2018 May 11. Epub 2018 May 11.

Department of Pharmacology, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India.

Sodium glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of anti-hyperglycaemic drugs with a distinctive mechanism of action focusing on renal absorption of glucose. Apart from its anti-hyperglycaemic effects, a multitude of research studies on this class have revealed that these drugs have far more versatile and comprehensive pharmacological effects than previously believed. Approximately 30% of FDA approved drugs are repurposed and used for indications other than those for which they were initially intended. Read More

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May 2018
2 Reads

Thymoquinone protects rat liver after partial hepatectomy under ischaemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention.

Clin Exp Pharmacol Physiol 2018 May 7. Epub 2018 May 7.

Faculté de Pharmacie, Unité de Biologie et Anthropologie Moléculaire Appliquées au Développement et à la Santé (UR12ES11), Université de Monastir, Monastir, Tunisia.

Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were divided equally into four groups (n = 6) receiving an oral administration of either vehicle solution (sham and PH groups) or TQ at 30 mg/kg (TQ and TQ + PH groups) for 10 consecutive days. Read More

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May 2018
2 Reads

Synthesis, characterization, molecular modelling and biological evaluation of thieno-pyrimidinone methanesulphonamide thio-derivatives as non-steroidal anti-inflammatory agents.

Clin Exp Pharmacol Physiol 2018 May 7. Epub 2018 May 7.

Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Catania, Italy.

This study reports the synthesis, molecular docking and biological evaluation of eight (5-8 and 5a-8a) newly synthesized thieno-pyrimidinone methanesulphonamide thio-derivatives. The synthetic route used to prepare the new isomers thioaryl and thio-cycloesyl derivatives of the heterocyclic system 6-phenylthieno[3,2]pyrimidinone was economically and environmentally very advantageous and characterized by the simplicity of procedure, reduction in isolation steps, purification phases, time, costs and waste production. The study in silico for the evaluation of cyclooxygenase (COX)-1 and COX-2 selective inhibition was carried out by AutoDock Vina, an open-source program for doing molecular docking which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex. Read More

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May 2018
2 Reads

Effects of the Kv7 voltage-activated potassium channel inhibitor linopirdine in rat models of haemorrhagic shock.

Clin Exp Pharmacol Physiol 2018 Apr 27. Epub 2018 Apr 27.

Department of Surgery, Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.

Recently, we demonstrated that Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements in short-term rat models of haemorrhagic shock. The aim of the present study was to further delineate the therapeutic potential and side effect profile of the Kv7 channel blocker linopirdine in various rat models of severe haemorrhagic shock over clinically relevant time periods. Intravenous administration of linopirdine, either before (1 or 3 mg/kg) or after (3 mg/kg) a 40% blood volume haemorrhage, did not affect blood pressure and survival in lethal haemorrhage models without fluid resuscitation. Read More

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April 2018
1 Read

The influence of ABCB1 and P2Y12 genetic variants on clinical outcomes in Chinese intracranial artery stenosis patients.

Clin Exp Pharmacol Physiol 2018 Apr 27. Epub 2018 Apr 27.

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.

For intracranial artery stenosis patients, high inter-individual variability in response to antiplatelet drug therapy results in recurrent ischemic events. We aimed to evaluate the association of drug-related genetic polymorphisms with adverse clinical outcomes. We consecutively enrolled 157 patients receiving dual-antiplatelet therapy (aspirin plus clopidogrel), and adverse clinical events occurred in 10 patients during the one year follow-up. Read More

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TRPV4 activates cytosolic phospholipase A via Ca -dependent PKC/ERK1/2 signalling in controlling hypertensive contraction.

Clin Exp Pharmacol Physiol 2018 Apr 27. Epub 2018 Apr 27.

School of Pharmaceutical Sciences and School of Medicine, Jiangnan University, Wuxi, China.

Activation of TRPV4 (transient receptor potential vanilloid 4) has been reported to result in endothelium-dependent contraction in the aortae of hypertensive mice. This contraction involved increased cPLA (cytosolic phospholipase A ) activity. The mechanism by which TRPV4 regulates cPLA activity to induce contraction in hypertension, however, is unknown. Read More

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April 2018
1 Read

Low doses of Paclitaxel repress breast cancer invasion through DJ-1/KLF17 signalling pathway.

Clin Exp Pharmacol Physiol 2018 Apr 27. Epub 2018 Apr 27.

Faculty of Science, Department of Zoology, Laboratory of Molecular Cell Biology, Assiut University, Assiut, Egypt.

Paclitaxel (taxol) is an important agent against many tumours, including breast cancer. Ample data documents that paclitaxel inhibits breast cancer metastasis while others prove that paclitaxel enhances breast cancer metastasis. The mechanisms by which paclitaxel exerts its action are not well established. Read More

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April 2018
1 Read

Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor.

Clin Exp Pharmacol Physiol 2018 Apr 26. Epub 2018 Apr 26.

Institute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.

Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many tissues. Read More

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April 2018
2 Reads

Protective effects of melatonin and glucagon-like peptide-1 receptor agonist (liraglutide) on gastric ischaemia-reperfusion injury in high-fat/sucrose-fed rats.

Clin Exp Pharmacol Physiol 2018 Apr 26. Epub 2018 Apr 26.

Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.

Ischaemia-reperfusion (I-R) injury is a serious pathology that is often encountered with thrombotic events, during surgery when blood vessels are cross-clamped, and in organs for transplantation. Increased oxidative stress is the main pathology in I-R injury, as assessed in studies on the heart, kidney, and brain with little data available on gastric I-R (GI-R). Liraglutide is a GLP-1 receptor agonist that has insulinotropic and weight reducing actions, and melatonin that has been much studied as a chronotropic hormone; have also studied as being anti-oxidative stress agents. Read More

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April 2018
4 Reads

Placental adaptations to micronutrient dysregulation in the programming of chronic disease.

Clin Exp Pharmacol Physiol 2018 Apr 21. Epub 2018 Apr 21.

School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold Coast Campus, Southport, QLD, Australia.

Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. Read More

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April 2018
4 Reads

Cardiovascular effects of sitagliptin - An anti-diabetes medicine.

Clin Exp Pharmacol Physiol 2018 Apr 21. Epub 2018 Apr 21.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Dipeptidyl-peptidase-4 (DPP-4) inhibitors, as the most recent available anti-diabetic agents, were generally used in clinical treatment of type 2 diabetes (T2DM). In addition to anti-diabetic effects, the five most widely used DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, linagliptin and alogliptin) also exert cardiovascular protective effects. In recent years, increasing studies suggest that sitagliptin shows pleiotropic impacts towards the cardiovascular system either with or without diabetes. Read More

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April 2018
2 Reads

Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage.

Clin Exp Pharmacol Physiol 2018 Apr 19. Epub 2018 Apr 19.

Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > . Read More

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April 2018
3 Reads

Treatment of ankylosing spondylitis with co-amoxiclav.

Authors:
Mesut Öğrendik

Clin Exp Pharmacol Physiol 2018 Apr 19. Epub 2018 Apr 19.

Consulting physician Department of Physical Medicine and Rehabilitation, Seyfi Demirsoy State Hospital, Buca, Izmir, Turkey.

This article presents the efficacy of co-amoxiclav in two patients with ankylosing spondylitis. Both patients were administered oral co-amoxiclav for 7 days. The primary efficacy variable was the ankylosing spondylitis activity index. Read More

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April 2018
1 Read

Differential cardiac sympatho-inhibitory responses produced by the agonists B-HT 933, quinpirole and immepip in normoglycaemic and diabetic pithed rats.

Clin Exp Pharmacol Physiol 2018 Apr 19. Epub 2018 Apr 19.

Department of Pharmacobiology, Cinvestav-Coapa, Mexico City, Mexico.

This study compared the cardiac sympatho-inhibitory responses produced by agonists at α -adrenergic (B-HT 933), dopamine D -like (quinpirole) and histamine H /H (immepip) receptors between normoglycaemic and streptozotocin-pretreated (diabetic) pithed rats. Intravenous (i.v. Read More

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April 2018
4 Reads

The Penumbral Role of Beta Blockade on Heart Rate Recovery in Heart Failure.

Authors:
Alan Pan

Clin Exp Pharmacol Physiol 2018 Apr 19. Epub 2018 Apr 19.

Presbyterian Intercommunity Hospital [PIH] Health, Whittier, CA, USA.

We would like to thank Bharadwaj et al. for their 2017 publication which provides robust evidence that subacute pyridostigmine administration heightens heart rate recovery (HRR) by augmenting cholinergic stimulus to the heart, thereby increasing parasympathetic tonus in heart failure (HF). Findings on HRR in the human population, which were published by another group in 2016 and correlate diminished HRR with HF mortality, belie what we truly know concerning the nebulous role that parasympathetic activation plays relative to standard therapy in HF. Read More

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April 2018
1 Read

Nephropreventing effect of hypoxia-inducible factor 1α in a rat model of ischemic/reperfusion acute kidney injury.

Clin Exp Pharmacol Physiol 2018 Apr 17. Epub 2018 Apr 17.

Department of Nephrology, 455th Hospital, The Institute of Nephrology in Nanjing Military Command, Shanghai, China, 200052.

Acute kidney injury (AKI) often occurs in 5% hospitalized patients and in 50% sepsis patients with acute renal dysfunction. However, there is no safe and effective therapeutic strategies until now. Hypoxia condition is closely related to renal injuries and function under AKI. Read More

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April 2018
2 Reads

Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway.

Clin Exp Pharmacol Physiol 2018 Apr 17. Epub 2018 Apr 17.

Department of Cardiology China-Japan, Union Hospital, Jilin University, Changchun, China.

This study aims to investigate whether the molecular mechanisms by which Ghrelin inhibits cardiac fibrosis are linked to the NADPH oxidase-ROS signaling pathway. Adult male Sprague Dawley (SD) rats were randomly divided into 4 groups: sham, myocardial infarction (MI), MI + Ghrelin (100 μg/kg, twice daily, subcutaneous for 4 weeks beginning 24 h post-MI), or Ghrelin alone. Adult rat cardiac fibroblasts (CFs) were isolated and pretreated with or without Ghrelin for 24 h, followed by stimulation with or without angiotensin II (Ang II) for another 24 h. Read More

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April 2018
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The role of interleukin-4 in rheumatic diseases.

Clin Exp Pharmacol Physiol 2018 Apr 14. Epub 2018 Apr 14.

Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Rheumatism is a group of diseases, most of which are autoimmune diseases, that violate joints, bones, muscles, blood vessels and related soft tissue. As is well known, cytokines play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, and systemic lupus erythematosus. Recently, the role of interleukin-4 (IL-4), which may participate in the mechanism of rheumatism, have been discovered. Read More

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April 2018
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Bone marrow - mesenchymal stem cells impact on the U937 cells in the presence of staphylococcal enterotoxin B (SEB).

Clin Exp Pharmacol Physiol 2018 Apr 14. Epub 2018 Apr 14.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The growing resistance against conventional chemotherapy in acute myeloid leukemia (AML) is a noticeable clinical concern. Therefore, many researchers are looking for novel substances to overcome drug resistance in cancer. Staphylococcal enterotoxin B (SEB) is a superantigen (SAg) and a promising compound which has lethal effects on malignant cells. Read More

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April 2018
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The glucagon-like peptide-1 receptor agonist Exendin-4, ameliorates contrast-induced nephropathy through suppression of oxidative stress, vascular dysfunction and apoptosis independent of glycaemia.

Clin Exp Pharmacol Physiol 2018 Apr 10. Epub 2018 Apr 10.

Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury, particularly in diabetic patients. Previous studies have shown renoprotective effects of glucagon-like peptide-1 (GLP-1) signalling; however, its role in CIN remains unexplored. This study investigates the prophylactic effect of exendin-4, a GLP-1R agonist, against CIN in a rat model mimicking both healthy and diabetic conditions. Read More

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April 2018
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Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes.

Clin Exp Pharmacol Physiol 2018 Apr 4. Epub 2018 Apr 4.

Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan.

Telmisartan (TEL) is a non-peptide blocker of angiotensin II type-1 (AT ) receptor. However, the mechanisms through which this drug interacts directly with ion currents in hearts remain largely unclear. Herein, we aim to investigate the effects of TEL the on ionic currents and membrane potential of murine HL-1 cardiomyocytes. Read More

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April 2018
8 Reads

Role of melatonin in blood pressure regulation: An adjunct anti-hypertensive agent.

Clin Exp Pharmacol Physiol 2018 Mar 30. Epub 2018 Mar 30.

School of Kinesiology, Western University, London, ON, Canada.

Cardiovascular diseases account for approximately one-third of all deaths each year. Of this, hypertension accounts for approximately 9.4 million deaths. Read More

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March 2018
2 Reads