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    6526 results match your criteria Clinical and Experimental Pharmacology and Physiology[Journal]

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    RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma.
    Clin Exp Pharmacol Physiol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Ultrasonography, Affiliated Hospital of Jining Medical University Jining, 272000, Shandong, China.
    Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide; however, clinical and pathological parameters have limited ability in discriminating between clinically significant and indolent ESCC. Since RasGRP3 transcript levels have prognostic value in discriminating ESCC with different clinical aggressiveness, we decided to investigate its putative oncogenic role in ESCC. We found that RasGRP3 was highly expressed in ESCC cells. Read More

    TNF-α level affects etanercept clearance: TNF-α concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis.
    Clin Exp Pharmacol Physiol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
    Etanercept (ETN) is a widely used anti- tumor necrosis factor-α (TNF-α) agent, which relieves the symptoms of ankylosing spondylitis (AS) by binding to TNF-α to inhibit its inflammation effects. In this study, the effect of TNF-α level on ETN clearance (CL) was investigated, and the TNF-α concentration was initially set as a correction factor for allometric scaling to improve the predictions of individual ETN CLs. Individual ETN CLs and TNF-α concentrations in healthy volunteers and patients with AS were determined by performing ETN pharmacokinetic studies in the two cohorts. Read More

    rs294775 is a cis-regulatory SNP for human UGT2B10.
    Clin Exp Pharmacol Physiol 2018 Feb 12. Epub 2018 Feb 12.
    State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, Yunnan, 650091, P. R. China.
    UGT2B10 is an important metabolism enzyme in human body and its substrates include multiple amine-containing compounds, especially nicotine, tamoxifen and multiple antidepressants. Multiple common SNPs have been observed in its promoter region, but their role in expression regulation has never been investigated. In this preliminary study, we identified a novel cis-regulatory SNP, rs294775, for UGT2B10 by plasmid construction, mutagenesis, and luciferase assay, whose mechanism was also investigated. Read More

    Drug-resistant epilepsy and topiramate: plasma concentration and frequency of epileptic seizures.
    Clin Exp Pharmacol Physiol 2018 Feb 9. Epub 2018 Feb 9.
    School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
    Topiramate (TPM) is a second-generation antiepileptic drug (AED), acting on drug-resistant epilepsy. The aim of the study was to evaluate the influence of the dose, use of other AEDs on TPM plasma concentration (C), and frequency of epileptic seizures. A cross-sectional analytical study was developed with patients aged 18-60 years, for diagnosis of drug-resistant epilepsy, using TPM in monotherapy or associated with other AEDs. Read More

    Excess weight in children and adolescents is associated with altered subendocardial blood supply among girls but not boys.
    Clin Exp Pharmacol Physiol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brazil.
    Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply-workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross-sectional study involved 789 individuals. Read More

    Ptrf transgenic mice exhibit obesity and fatty liver.
    Clin Exp Pharmacol Physiol 2018 Jan 30. Epub 2018 Jan 30.
    Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China.
    Polymerase I and transcript release factor (Ptrf, also known as Cavin1) is an essential component in the biogenesis and function of caveolae. Ptrf knockout mice or patients with PTRF mutations exhibit numerous pathologies including markedly aberrant fuel metabolism, lipodystrophy and muscular dystrophy. In this study, we generated Ptrf transgenic mice to explore its function in vivo. Read More

    Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke.
    Clin Exp Pharmacol Physiol 2018 Jan 30. Epub 2018 Jan 30.
    School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia.
    Sex differences in disease susceptibility due to maternal programming have been reported. We previously observed that maternal smoking induced renal disease and neurological changes are restricted to males, whilst both male and female offspring develop metabolic disorders. We have also found that maternal L-carnitine supplementation during gestation and lactation can significantly improve glucose intolerance and hyperlipidaemia in male offspring. Read More

    Use of atropine in four-dimensional hysterosalpingo-contrast sonography: does it suppress pain during infertility examination?
    Clin Exp Pharmacol Physiol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Ultrasound, Jiangsu Province Hospital of Traditional Chinese Medicine, 155 Han Zhong Road, Nanjing, Jiangsu, 210029, China.
    We wished to ascertain if atropine is useful for suppressing the pain suffered during four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) when assessing infertility in women. A total of 252 patients were divided into two groups to receive or not receive atropine (0.5 mg) injection 30 min before 4D-HyCoSy. Read More

    Mechanoelectrical transduction in chondrocytes.
    Clin Exp Pharmacol Physiol 2018 Jan 23. Epub 2018 Jan 23.
    School of Medical Sciences, EMBL Australia node for Single Molecule Sciences, University of New South Wales, Sydney, NSW, Australia.
    Cartilage tissue lines the joints of mammals, helping to lubricate joint movement and distribute mechanical loads. This tissue is comprised of isolated cells known as chondrocytes which are embedded in an extracellular matrix. Chondrocytes produce and maintain the cartilage by sensing and responding to changing mechanical loads. Read More

    PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone.
    Clin Exp Pharmacol Physiol 2018 Jan 23. Epub 2018 Jan 23.
    Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.
    Numerous studies have reported that inflammation is involved in the pathophysiology of depression. Pioglitazone, a PPAR-γ agonist, has potential anti-inflammatory and antidepressive effects. However, the underlying molecular mechanisms of the antidepressant-like effect of pioglitazone on an inflammation-related mouse model of depression remain to be fully elucidated. Read More

    Novel cardiovascular magnetic resonance oxygenation approaches in understanding pathophysiology of cardiac diseases.
    Clin Exp Pharmacol Physiol 2018 Jan 19. Epub 2018 Jan 19.
    Cardiac Imaging Research Group, South Australian Health & Medical Research Institute, Adelaide, SA, Australia.
    Cardiovascular magnetic resonance imaging (CMR) permits accurate phenotyping of many cardiac diseases. CMR's inherent advantages are its non-invasive nature, lack of ionizing radiation and high accuracy and reproducibility. Furthermore, it is able to assess many aspects of cardiac anatomy, structure and function. Read More

    Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats.
    Clin Exp Pharmacol Physiol 2018 Jan 18. Epub 2018 Jan 18.
    Department of Physiology, Faculty of Medicine, Biruni University, Istanbul, Turkey.
    The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this study, we explored the mechanisms underlying the analgesic effect of salmon calcitonin on migrane pain using glyceryltrinitrate (GTN)-induced model of migraine and ex vivo meningeal preparations in rats. Read More

    Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells.
    Clin Exp Pharmacol Physiol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Chonbuk National University, Jeonju, South Korea.
    Gomisin A from the fruit of Schisandra chinensis has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative stress. However, the potential benefit of gomisin A is still not well understood, especially in aging progression. Therefore, the aim of this study was to clarify whether the promotion of mitochondrial biogenesis and autophagy of gomisin A affects anti-aging progression, and its mechanism. Read More

    CD4T cell imbalance is associated with recurrent endometrial polyps.
    Clin Exp Pharmacol Physiol 2018 Jan 2. Epub 2018 Jan 2.
    Department of Gynaecology, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, Guangdong, China.
    Endometrial polyps (EPs) are localized benign overgrowths at the endometrium, with currently unknown aetiology and pathogenesis. Although symptoms of EP can be alleviated or resolved by hysteroscopic polypectomy, a significant fraction of individuals develop recurrent EPs after initial EP removal. In rare cases, EPs may also undergo malignant transformation. Read More

    MiR-96 regulates bone metabolism by targeting osterix.
    Clin Exp Pharmacol Physiol 2017 Dec 30. Epub 2017 Dec 30.
    Department of Infectious Diseases, The Xiangya Hospital of Central South University, Changsha, China.
    MicroRNAs (miRNAs) play important roles in bone metabolism and aging. Here we show that miR-96 was markedly up-regulated in serum of elderly patients with osteoporosis by miRNA microarray analysis and qRT-PCR. Moreover miR-96 was also up-regulated in bone marrow mesenchymal stem cells (BMSCs) of aged humans and mice. Read More

    Association between UDP-glucuronosyltransferase 2B7 tagSNPs and breast cancer risk in Chinese females.
    Clin Exp Pharmacol Physiol 2017 Dec 22. Epub 2017 Dec 22.
    Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
    This retrospective study was performed to evaluate the association between the UGT2B7 tagSNPs (rs12233719, rs4356975, rs7435335 and rs7441774) and breast cancer in Chinese females. Blood samples were collected from 672 patients with breast cancer and 670 healthy controls for DNA extraction. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to analyze UGT2B7 polymorphisms. Read More

    Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model.
    Clin Exp Pharmacol Physiol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Angiogenesis is a process through which new capillaries are formed from pre-existing ones, which contributes significantly to the pathogenesis of numerous diseases, such as cancer and chronic inflammatory disorders. The β-D-mannuronic acid (M2000) is a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive effects and is a matrix metalloproteinase (MMP) inhibitor. This research aimed to study the anti-angiogenesis effects of M2000 under in vitro and in vivo models. Read More

    Hyperuricaemia and development of type 2 diabetes mellitus in Asian population.
    Clin Exp Pharmacol Physiol 2017 Dec 20. Epub 2017 Dec 20.
    Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
    Recently, meta-analysis studies reported that hyperuricaemia is associated with higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited data on the Asian population. The aim of this observational study is to estimate the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular events. This study is based on a single-centre, all-comers, and large retrospective cohort. Read More

    Diallyl sulfide alleviates cisplatin-induced nephrotoxicity in rats via suppressing NF-κB downstream inflammatory proteins and p53/Puma signalling pathway.
    Clin Exp Pharmacol Physiol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Pharmacology & Toxicology, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
    Despite being a potent anticancer drug, nephrotoxicity is an adverse effect which renders the clinical use of cisplatin (Cis) limited. The protective role of diallyl sulfide (DAS); a naturally occurring organo-sulfide, present in garlic, in cisplatin-induced nephrotoxicity has been reported earlier. However, the mechanism through which DAS exerts its nephroprotective activity remains elusive. Read More

    Arginase and α-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia.
    Clin Exp Pharmacol Physiol 2017 Dec 20. Epub 2017 Dec 20.
    Pulmonary Hypertension Group, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
    The L-arginine/NO pathway is an important regulator of pulmonary hypertension, the leading cause of mortality in patients with the chronic lung disease of prematurity, bronchopulmonary dysplasia. L-arginine can be metabolized by NO synthase (NOS) to form L-citrulline and NO, a potent vasodilator. Alternatively, L-arginine can be metabolized by arginase to form urea and L-ornithine, a precursor to collagen and proline formation important in vascular remodelling. Read More

    Anti-contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high-fat diet: role of aerobic exercise training.
    Clin Exp Pharmacol Physiol 2018 Mar 19;45(3):293-302. Epub 2017 Dec 19.
    Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
    The aim of the present study was to evaluate the effects of aerobic exercise training on perivascular adipose tissue (PVAT) function in thoracic aorta from rats fed a high-fat diet. Aortic vascular reactivity was performed in sedentary (SD), trained (TR), sedentary high-fat diet (SD-HF), and trained high-fat diet (TR-HF) male Wistar rats in the absence (PVAT-) or in the presence (PVAT+) of thoracic PVAT. We also measured circulatory concentrations of leptin and tumour necrosis factor alpha (TNF-α), as well as the protein expressions of TNF-α receptor 1 (TNFR1) and inducible nitric oxide synthase (iNOS) on PVAT. Read More

    Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney.
    Clin Exp Pharmacol Physiol 2018 Mar 12;45(3):250-260. Epub 2017 Dec 12.
    Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria, Australia.
    Cyclophilin D (CypD) is an important component in mitochondrial-dependent tubular cell death in acute kidney injury. However, it is not known whether CypD contributes to tubular cell damage in chronic interstitial fibrosis. We investigated this question in the unilateral ureter obstruction (UUO) model of renal interstitial fibrosis. Read More

    Dose rectification of an imbalance between DPP4 and GLP-1 ameliorates chronic stress-related vascular aging and atherosclerosis?
    Clin Exp Pharmacol Physiol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Cardiology and Heart Center, Yanbian University Hospital, Yanji, Jilin, China.
    Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Dipeptidyl peptidase-4 (DPP-4) exerts many physiological and pharmacological functions by regulating its extremely abundant substrates [eg., glucagon-like peptide-1 (GLP-1), stromal cell-derived factor-1α/C-X-C chemokine receptor type-4, etc. Read More

    Zinc against advanced glycation end products.
    Clin Exp Pharmacol Physiol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
    Advanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age-related chronic diseases. Zinc has antioxidant, anti-inflammatory and anti-apoptotic potential. This study aimed to summarize effects of zinc on AGE formation and AGE-induced damaging agents. Read More

    Downregulation of regulatory T cell function in patients with delayed fracture healing.
    Clin Exp Pharmacol Physiol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Orthopedics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
    Bone fracture healing is a multistage regenerative process that requires the collaboration of various cell types, with approximately 5%-10% of fractures not healing properly. Accumulating evidence suggests that dysregulations in the immune system are associated with defective healing. In a cohort of 30 bone fracture patients between 50 and 62 years of age, 8 patients displayed delayed healing. Read More

    Proteomic response of the rat liver in differential swimming modes.
    Clin Exp Pharmacol Physiol 2017 Dec 7. Epub 2017 Dec 7.
    Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, China.
    Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between 2 swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to 2-dimensional electrophoresis (2DE). Read More

    2D speckle tracking echocardiography of the right ventricle free wall in SCUBA divers after single open sea dive.
    Clin Exp Pharmacol Physiol 2018 Mar 7;45(3):234-240. Epub 2017 Dec 7.
    Department of Cardiology, Clinical Hospital Split, Split, Croatia.
    The presence of circulating gas bubbles and their influence on pulmonary and right heart hemodynamics was reported after uncomplicated self-contained underwater breathing apparatus (SCUBA) dive(s). Improvements in cardiac imaging have recently focused great attention on the right ventricle (RV). The aim of our study was to evaluate possible effects of a single air SCUBA dive on RV function using 2D speckle tracking echocardiography in healthy divers after single open sea dive to 18 meters of seawater, followed by bottom stay of 47 minutes with a direct ascent to the surface. Read More

    Clinical relevance of deferasirox trough levels in β-thalassemia patients.
    Clin Exp Pharmacol Physiol 2018 Feb 4;45(2):213-216. Epub 2017 Dec 4.
    Department of Paediatrics, Centre for Microcitemie, University of Turin, S. Luigi Gonzaga Hospital, Orbassano, Italy.
    We evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty-four β-thalassemic adult patients were enrolled: 50% were males; median age was 32. Read More

    Diastolic dysfunction in pulmonary artery hypertension: Creatine kinase and the potential therapeutic benefit of beta-blockers.
    Clin Exp Pharmacol Physiol 2017 Nov 28. Epub 2017 Nov 28.
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK.
    Passive properties of the myocardium influence diastolic filling and cardiac output. In heart failure, changes in contributors to the passive properties of the ventricle, such as titin and collagen, and loss of the metabolic enzyme creatine kinase, increase resistance to filling resulting in diastolic dysfunction. Pulmonary artery hypertension (PAH) arises from interactions between the pulmonary vasculature and the right ventricle (RV) which ultimately leads to RV failure. Read More

    Synergism of amlodipine and candesartan on blood pressure reduction and organ protection in hypertensive rats.
    Clin Exp Pharmacol Physiol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China.
    This study was designed to investigate the possible synergism of amlodipine and candesartan on the reduction of blood pressure (BP) in hypertensive rats. The end organ protection was also observed. In acute experiment, spontaneously hypertensive rats (SHRs) were treated with intragastric administration of amlodipine (0. Read More

    Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life.
    Clin Exp Pharmacol Physiol 2017 Nov 29. Epub 2017 Nov 29.
    Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
    Aquaporin (AQP) channels in the major intrinsic protein (MIP) family are known to facilitate transmembrane water fluxes in prokaryotes and eukaryotes. Some classes of AQPs also conduct ions, glycerol, urea, CO, nitric oxide, and other small solutes. Ion channel activity has been demonstrated for mammalian AQPs 0, 1, 6, Drosophila Big Brain (BIB), soybean nodulin 26, and rockcress AtPIP2;1. Read More

    Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances.
    Clin Exp Pharmacol Physiol 2017 Nov 29. Epub 2017 Nov 29.
    School of Human Sciences, the University of Western Australia, Perth, WA, Australia.
    The clinical need and historical approaches to tissue engineering as applied to regenerative medicine are introduced, along with comments on activities in this field around Australia, and then the huge advances for tissue culture studies are discussed (Part A). Combinations of human stem cells and new approaches for generating bioscaffolds present great opportunities for in vitro studies of basic biology and physiology, drug testing and high throughput screening for the pharmaceutical industry, and the advanced tissue engineering of organs and devices. The future here is bright. Read More

    Inhibitory effect of naringenin via IL-13 level regulation on thymic stromal lymphopoietin-induced inflammatory reactions.
    Clin Exp Pharmacol Physiol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Asan, Chungnam, Korea.
    Naringenin (NG) has various beneficial properties, such as anti-cancer and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) induces mast cell proliferation and inflammatory reactions. The aim of this study was to investigate the regulatory effect of NG on TSLP-induced mast cell proliferation and inflammatory reactions using human mast cell line (HMC-1) cells. Read More

    Aging mechanisms and intervention targets.
    Clin Exp Pharmacol Physiol 2017 Dec;44 Suppl 1:3-8
    School of Medicine, Institute of Ageing Research, Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
    Premature aging occurs frequently to various tissues and organs resulting in the tissue-specific chronic diseases. The mechanisms of tissue-specific premature aging are largely unknown. In response to environmental cues, aging may originate from cytoplasm or the nucleus of a cell with cytoplasm aging in association with organelle degeneration in terminally differentiated cells and nuclear aging with dysfunctional telomeres and irreversible cell cycle arrest in stem and cancer cells. Read More

    Maternal protein malnutrition induced-hypertension: New evidence about the autonomic and respiratory dysfunctions and epigenetic mechanisms.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Physical Education and Sport Sciences, Federal University of Pernambuco, UFPE, Vitória de Santo Antão-PE, Brazil.
    Maternal protein malnutrition during the critical stages of development (pregnancy, lactation and first infancy) can lead to adult hypertension. Studies have shown that renal and cardiovascular dysfunctions can be associated to the development of hypertension in humans and rats exposed to maternal protein malnutrition. The etiology of hypertension, however, includes a complex network involved in central and peripheral blood pressure control. Read More

    Ameliorative effects of riboflavin on acetic acid-induced colonic injury in rats.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
    Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study aimed to investigate the potential antioxidant and protective effects of RF in a rat model of ulcerative colitis. Read More

    Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Otorhinolaryngology and Maxillofacial Oncology, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.
    Expression of DCUN1D1 in laryngeal squamous cell carcinoma (LSCC) and its inhibition by small interfering RNA (siRNA) target in the TU-177 cells was investigated. Immunohistochemistry was used to detect the expression level of DCUN1D1 in LSCC tissue in 140 cases and to analyze its relationship with clinical pathological characteristics. siRNA expression plasmid targeting DCUN1D1 was constructed and transferred into TU-177 cells. Read More

    Resveratrol protects Leydig cells from nicotine-induced oxidative damage through enhanced autophagy.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Urology, The First People's Hospital of Xianyang City, Xianyang, Shaanxi, China.
    Some studies have revealed that nicotine can damage the male reproductive system through various means including oxidative stress, which is a primary factor in the pathogenesis of male infertility. The strong anti-oxidative capacity of resveratrol has been demonstrated previously, but its role in the context of male reproduction remains inconclusive. To explore the biological role of resveratrol in protecting male reproductive function and the potential underlying mechanism, nicotine-induced Leydig cells were used as a cell model of oxidative damage. Read More

    MicroRNA-26a inhibits proliferation and tumorigenesis via targeting CKS2 in laryngeal squamous cell carcinoma.
    Clin Exp Pharmacol Physiol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Otolaryngology, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan, China.
    Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancers, with high mortality and incidence. MicroRNA-26a (miR-26a) is involved in the development and progression of several tumours. However, the roles of miR-26a and its target CKS2 in LSCC progression are not yet clear. Read More

    Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.
    Clin Exp Pharmacol Physiol 2017 Nov 16. Epub 2017 Nov 16.
    Institute of Life Sciences, Jiangsu University, Zhenjiang, China.
    Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Read More

    Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease.
    Clin Exp Pharmacol Physiol 2018 Mar 28;45(3):241-249. Epub 2017 Nov 28.
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
    Tubular epithelial cells take up and degrade plasma albumin filtered by the glomerulus. Tubular damage resulting in reduced albumin uptake or degradation has been suggested as one mechanism contributing to albuminuria in kidney disease. This study investigated whether tubular albumin uptake or degradation is altered in acute and chronic glomerular disease. Read More

    Regulation of thyroid sodium-iodide symporter in different stages of goiter: Possible involvement of reactive oxygen species.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Laboratório de Fisiologia Endócrina Doris Rosenthal, IBCCF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Na/Isymporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. Read More

    Role of mitochondria and mitochondria-targeted agents in non-alcoholic fatty liver disease.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Biochemistry, Amala Institute of Medical Sciences, Kerala, India.
    Mitochondria play a pivotal role in the fatty acid oxidation and have been found to be affected early during the macrovesicular fat accumulation in the hepatocytes. The fatty infiltration is the primary cause of oxidative stress and inflammation in the non-alcoholic fatty liver disease (NAFLD), which can lead to the peroxidation of phospholipids, such as cardiolipin. Oxidative stress-induced damage to mitochondrial DNA can result in the impairment of oxidative phosphorylation and further increases the generation of reactive oxygen species. Read More

    Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China.
    Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2. Read More

    Dynamic changes of the composition of plasma HDL particles in patients with cardiac disease: Spotlight on sphingosine-1-phosphate/serum amyloid A ratio.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National Children Hospital, Dublin, Ireland.
    Several epidemiological studies reported an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and atherosclerotic cardiovascular disease (ASCVD). However, therapeutic interventions targeted at raising HDL-cholesterol failed to improve cardiovascular outcomes, suggesting that HDL components distinct from cholesterol may account for the anti-atherothrombotic effects attributed to this lipoprotein. Sphingosine-1-phosphate (S1P) and the acute phase protein serum amyloid A (SAA) have been identified as integral constituents of HDL particles. Read More

    Jekyll and Hyde of chemotherapy treatment: Method for patient-specific dosing of chemotherapy medications.
    Clin Exp Pharmacol Physiol 2018 Mar 19;45(3):312-316. Epub 2017 Dec 19.
    Calgary, Alberta, Canada.
    Currently chemotherapy dosing is determined by a patient's weight, height and renal function. Dosing chemotherapy based on these parameters is generally effective, assuming all other physiological conditions are normal. In hypoalbuminaemia patients a decrease in albumin often results in more severe side-effects, since this may lead to higher chemotherapy free drug levels. Read More

    The neuronal and endocrine roles of RCAN1 in health and disease.
    Clin Exp Pharmacol Physiol 2017 Nov 1. Epub 2017 Nov 1.
    College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.
    The regulator of calcineurin 1 (RCAN1) was first discovered as a gene located on human chromosome 21, expressed in neurons and overexpressed in the brains of Down syndrome individuals. Increased expression of RCAN1 has been linked with not only Down syndrome-associated pathology but also an associated neurological disorder, Alzheimer's Disease, in which neuronal RCAN1 expression is also increased. RCAN1 has additionally been demonstrated to affect other cell types including endocrine cells, with links to the pathogenesis of β-cell dysfunction in type 2 diabetes. Read More

    Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2.
    Clin Exp Pharmacol Physiol 2018 Mar 20;45(3):303-311. Epub 2017 Dec 20.
    Department of Cardiology, the First Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China.
    Baicalin, a flavonoid glycoside separated from Scutellaria baicalensis, has cardioprotection against ischaemia/reperfusion (I/R) injury. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is considered as an endogenous protective mechanism against I/R injury depending on its anti-oxidant and anti-apoptotic characteristics. The present study demonstrates whether ALDH2 contributes to the cardioprotection of baicalin against hypoxia/reoxygenation (H/R)-inudced H9c2 cardiomyocytes injury. Read More

    Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.
    Clin Exp Pharmacol Physiol 2018 Mar 28;45(3):226-233. Epub 2017 Nov 28.
    Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.
    Epilepsy is a common complex neurological disorder, and some forms are resistant to drug treatment. The HCN1/HCN2 genes encode hyperpolarization-activated cyclic nucleotide-gated channels, which play important roles in the electrophysiology of neurons. We investigated the association between HCN1/HCN2 variants and drug resistance or the risk of genetic generalized epilepsies (GGEs). Read More

    Involvement of NF-κB in the upregulation of cystathionine-γ-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice.
    Clin Exp Pharmacol Physiol 2017 Oct 17. Epub 2017 Oct 17.
    Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka, Japan.
    Hydrogen sulfide (HS) is generated from l-cysteine by multiple enzymes including cystathionine-γ-lyase (CSE), and promotes nociception by targeting multiple molecules such as Ca3.2 T-type Cachannels. Bladder pain accompanying cyclophosphamide (CPA)-induced cystitis in mice has been shown to involve the functional upregulation of the CSE/HS/Ca3. Read More

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