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    6492 results match your criteria Clinical and Experimental Pharmacology and Physiology[Journal]

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    Maternal protein malnutrition induced-hypertension: new evidence about the autonomic and respiratory dysfunctions and epigenetic mechanisms.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Physical Education and Sport Sciences, Federal University of Pernambuco, UFPE, Vitória, de Santo Antão - PE, 55608-680, Brazil.
    Maternal protein malnutrition during the critical stages of development (pregnancy, lactation and first infancy) can lead to adult hypertension. Studies have shown that renal and cardiovascular dysfunctions can be associated to the development of hypertension in humans and rats exposed to maternal protein malnutrition. The etiology of hypertension, however, includes a complex network involved in central and peripheral blood pressure control. Read More

    Ameliorative effects of riboflavin on acetic acid-induced colonic injury in rats.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.
    Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study aimed to investigate the potential antioxidant and protective effects of RF in a rat model of ulcerative colitis. Read More

    Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Otorhinolaryngology and Maxillofacial Oncology, Tianjin Medical University Cancer Institute, Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute; National Clinical Research Center of Cancer;, Tianjin.
    Expression of DCUN1D1 in laryngeal squamous cell carcinoma(LSCC) and its inhibition by small interfering RNA(siRNA) target in the TU-177 cells was investigated. Immunohistochemistry was used to detect the expression level of DCUN1D1 in LSCC tissue in 140 cases and analyze its relationship with clinical pathological characteristics. siRNA expression plasmid targeting DCUN1D1 was constructed and transferred into TU-177 cells. Read More

    Resveratrol protects Leydig cells from nicotine-induced oxidative damage through enhanced autophagy.
    Clin Exp Pharmacol Physiol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Urology, the first people's Hospital of Xianyang City, Shaanxi, China.
    Some studies have revealed that nicotine can damage the male reproductive system through various ways including oxidative stress, which is a primary factor in the pathogenesis of male infertility. The strong antioxidative capacity of resveratrol has been demonstrated previously, but its role in the context of male reproduction remains inconclusive. To explore the biological role of resveratrol in protecting male reproductive function and the potential underlying mechanism, nicotine-induced Leydig cells were used as a cell model of oxidative damage. Read More

    MicroRNA-26a inhibits proliferation and tumorigenesis via targeting CKS2 in laryngeal squamous cell carcinoma.
    Clin Exp Pharmacol Physiol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Otolaryngology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang, 453100, Henan, P. R. China.
    Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancer, with high mortality and incidence. MicroRNA-26a (miR-26a) is involved in the development and progression of several tumors. However, the roles of miR-26a and its target CKS2 in LSCC progression are not yet clear. Read More

    Identification of a Pyridine Derivative Inducing Senescence in Ovarian Cancer Cell lines via P21 Activation.
    Clin Exp Pharmacol Physiol 2017 Nov 16. Epub 2017 Nov 16.
    Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
    Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumor suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Read More

    Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease.
    Clin Exp Pharmacol Physiol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Nephrology, Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria, Australia.
    Tubular epithelial cells take up and degrade plasma albumin filtered by the glomerulus. Tubular damage resulting in reduced albumin uptake or degradation has been suggested as one mechanism contributing to albuminuria in kidney disease. This study investigated whether albumin uptake or degradation is altered in acute and chronic glomerular disease. Read More

    Regulation of thyroid sodium-iodide symporter in different stages of goiter: possible involvement of ROS.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Laboratório de Fisiologia Endócrina Doris Rosenthal, IBCCF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Na(+) /I(-) symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. Read More

    Role of mitochondria and mitochondria targeted agents in non-alcoholic fatty liver disease.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Biochemistry, Amala Institute of Medical Sciences, Thrissur-680 555, Kerala, India.
    Mitochondria play a pivotal role in the fatty acid oxidation and have been found to be affected early during the macrovesicular fat accumulation in the hepatocytes. The fatty infiltration is the primary cause of oxidative stress and inflammation in the non-alcoholic fatty liver disease (NAFLD), which can lead to the peroxidation of phospholipids, such as cardiolipin. Oxidative stress-induced damage to mitochondrial DNA can result in the impairment of oxidative phosphorylation and further increases the generation of reactive oxygen species. Read More

    Interactive effects of morphine and dopamine receptor agonists on spatial recognition memory in mice.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming, Yunnan, 650550, P.R. China.
    Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2. Read More

    Dynamic Changes of the Composition of Plasma HDL Particles in Patients with Cardiac Disease: Spotlight on Sphingosine-1-phosphate: Serum Amyloid A Ratio.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Department of cardiology, The Adelaide and Meath Hospital Dublin, Incorporating the National children hospital, Tallaght, Dublin, 24.
    Several epidemiological studies reported an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and atherosclerotic cardiovascular disease (ASCVD). However, therapeutic interventions targeted at raising HDL-cholesterol failed to improve cardiovascular outcomes, suggesting that HDL components distinct from cholesterol may account for the anti-atherothrombotic effects attributed to this lipoprotein. Sphingosine-1-phosphate (S1P) and the acute phase protein serum amyloid A (SAA) have been identified as integral constituents of HDL particles. Read More

    Jekyll and Hyde of chemotherapy treatment: method for patient specific dosing of chemotherapy medications.
    Clin Exp Pharmacol Physiol 2017 Nov 2. Epub 2017 Nov 2.
    60 Woodbrook Close SW, Calgary, Alberta.
    Currently chemotherapy dosing is determined by a patient's weight, height and renal function. Dosing chemotherapy based on these parameters is generally effective, assuming all other physiological conditions are normal. In hypoalbuminemia patients a decrease in albumin often results in more severe side-effects, since this may lead to higher chemotherapy free drug levels. Read More

    The neuronal and endocrine roles of RCAN1 in health and disease.
    Clin Exp Pharmacol Physiol 2017 Nov 1. Epub 2017 Nov 1.
    College of Medicine and Public Health and Centre for Neuroscience, Flinders University, Adelaide, SA, 5042, Australia.
    Regulator of calcineurin 1 (RCAN1) was first discovered as a gene located on human chromosome 21, expressed in neurons and overexpressed in the brains of Down Syndrome individuals. Increased expression of RCAN1 has been linked with not only Down Syndrome-associated pathology but also an associated neurological disorder, Alzheimer's Disease, in which neuronal RCAN1 expression is also increased. RCAN1 has additionally been demonstrated to effect other cell types including endocrine cells, with links to the pathogenesis of β-cell dysfunction in type 2 diabetes. Read More

    Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2.
    Clin Exp Pharmacol Physiol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Cardiology, the First Hospital Affiliated to Soochow University, Suzhou, Jiangsu, 215006, China.
    Baicalin, a flavonoid glycoside separated from Scutellaria baicalensis, has cardioprotection against ischemia/reperfusion (I/R) injury. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is considered as an endogenous protective mechanism against I/R injury depending on its antioxidant and antiapoptotic characteristics. Herein, the present study demonstrate whether ALDH2 contributes to the cardioprotection of baicalin against hypoxia/reoxygenation (H/R)-inudced H9c2 cardiomyocytes injury. Read More

    Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.
    Clin Exp Pharmacol Physiol 2017 Oct 19. Epub 2017 Oct 19.
    Department of Pharmacy, the Second Xiangya Hospital, Central South University; Institute of Clinical Pharmacy, Central South University, 410011, Changsha, China.
    Epilepsy is a common complex neurological disorder, and some forms are resistant to drug treatment. The HCN1/HCN2 genes encode hyperpolarization-activated cyclic nucleotide-gated channels, which play important roles in the electrophysiology of neurons. We investigated the association between HCN1/HCN2 variants and drug resistance or the risk of genetic generalized epilepsies (GGEs). Read More

    Involvement of NF-κB in the upregulation of cystathionine-γ-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice.
    Clin Exp Pharmacol Physiol 2017 Oct 17. Epub 2017 Oct 17.
    Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi- Osaka, 577-8502, Japan.
    Hydrogen sulfide (H2 S) is generated from L-cysteine by multiple enzymes including cystathionine-γ-lyase (CSE), and promotes nociception by targeting multiple molecules such as Cav 3.2 T-type Ca(2+) channels. Bladder pain accompanying cyclophosphamide (CPA)-induced cystitis in mice has been shown to involve the functional upregulation of the CSE/H2 S/Cav 3. Read More

    Effect of androgen deprivation therapy on the contractile properties of type I and type II skeletal muscle fibres in men with non-metastatic prostate cancer.
    Clin Exp Pharmacol Physiol 2017 Oct 17. Epub 2017 Oct 17.
    School of Life Sciences, La Trobe University, Melbourne, 3086, VIC, Australia.
    The contractile properties of vastus lateralis muscle fibres were examined in prostate cancer (PrCa) patients undergoing androgen deprivation therapy (ADT) and in age- and activity-matched healthy male subjects (Control). Mechanically-skinned muscle fibres were exposed to a sequence of heavily Ca(2+) -buffered solutions at progressively higher free [Ca(2+) ] to determine their force-Ca(2+) relationship. Ca(2+) -sensitivity was decreased in both type I and type II muscle fibres of ADT subjects relative to Controls (by -0. Read More

    Comorbid masticatory impairment delays recovery from acute cerebral ischemia and locomotor hypoactivity after subarachnoid hemorrhage in mice.
    Clin Exp Pharmacol Physiol 2017 Oct 17. Epub 2017 Oct 17.
    Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-AKITA, Akita, Japan.
    Tooth loss and related changes in the functionality may lead to worse outcome of stroke patients, but the link involved in this pathway remains unclear. This study aimed to determine the effect of comorbid masticatory impairment on acute cerebral ischemia and neurobehavioral outcome after experimental subarachnoid hemorrhage (SAH). Thirty C57BL/6 mice with (molar-less) or without (control) prior treatment of cutting off the upper molars (separated by at least one week), were subjected to SAH by endovascular perforation. Read More

    The mechanism of attenuation of epithelial-mesenchymal transition by a phosphodiesterase 5 inhibitor via renal klotho expression.
    Clin Exp Pharmacol Physiol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea.
    Phosphodiesterase-5 (PDE-5) inhibitors induces vasodilation in several organs by blocking cyclic GMP (guanosine monophosphate) degradation. However, the existence of alternative mechanism of action in case of an impaired nitric oxide (NO) system remains controversial. Previous studies suggested that decreased NO bioavailability may result in the downregulation of klotho expression, but the relationship between klotho and NO remains obscure. Read More

    Early urinary biomarkers of renal tubular damage by a high-salt intake independent of blood pressure in normotensive rats.
    Clin Exp Pharmacol Physiol 2017 Oct 12. Epub 2017 Oct 12.
    Department of Urology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
    Dietary sodium intake has been associated with progression to chronic kidney disease (CKD) as well as hypertension. A high-salt intake causes renal damage independent of hypertension. Because traditional renal biomarkers are insensitive, it is difficult to detect renal injury induced by a high-salt intake, especially in normotensive patients. Read More

    Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.
    Clin Exp Pharmacol Physiol 2017 Oct 12. Epub 2017 Oct 12.
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG.
    Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly perturbs myocyte Ca(2+) homeostasis, slows myocardial action potential conduction, and exerts pro-arrhythmic effects. Loose patch-clamp studies, preserving in vivo extracellular and intracellular conditions, investigated Na(+) current in intact cardiomyocytes in murine atrial and ventricular preparations following Epac activation. Depolarising steps to varying test voltages activated typical voltage-dependent Na(+) currents. Read More

    The Ineluctable Constraints of Thermodynamics in the Aetiology of Obesity.
    Clin Exp Pharmacol Physiol 2017 Oct 10. Epub 2017 Oct 10.
    Auckland Bioengineering Institute Honorary membership.
    We exploit the detail-independence feature of thermodynamics to examine issues related to the development of obesity. We adopt a 'global' approach consistent with focus on the First Law - namely that the metabolic energy provided by dietary foodstuffs has only three possible fates: the performance of work (be it microscopic or macroscopic), the generation of heat, or storage - primarily in the form of adipose tissue. Quantification of the energy expended, in the form of fat metabolised, during selected endurance events, reveals the inherent limitation of over-reliance on exercise as a primary agent of weight-loss. Read More

    Reduced CBF recovery detected by longitudinal 3D-SSP SPECT analyses predicts outcome of postoperative patients after subarachnoid hemorrhage.
    Clin Exp Pharmacol Physiol 2017 Oct 5. Epub 2017 Oct 5.
    Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-AKITA, Akita, Japan.
    The aim of this study was to evaluate the impact of cerebral blood flow (CBF) recovery obtained from brain single-photon emission computed tomography (SPECT) images on postoperative outcome after aneurysmal subarachnoid hemorrhage (SAH). Twenty-nine patients who had undergone surgical clipping for ruptured anterior communicating artery aneurysms were analyzed prospectively. Routine measurements of CBF were performed using technetium-99m hexamethyl propyleneamine oxine SPECT on days 4 and 14 after SAH. Read More

    Prorenin receptor mediates inflammation in renal ischemia.
    Clin Exp Pharmacol Physiol 2017 Oct 5. Epub 2017 Oct 5.
    Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA, USA.
    We hypothesized that PRR contributes to renal inflammation in the 2-kidney, 1-clip (2K1C) renal ischaemia model. Male Sprague-Dawley rats were fed normal sodium diet. Blood pressure (BP) was obtained on days 0 and 28 after left renal artery clipping that reduced renal blood flow by 40%. Read More

    Early sex differences in central arterial wave reflection are mediated by different timing of forward and reflected pressure waves.
    Clin Exp Pharmacol Physiol 2017 Oct 3. Epub 2017 Oct 3.
    Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espirito Santo, ES, Brazil.
    Non-invasive assessment of central arterial pulse wave augmentation has been proved to be useful in predicting cardiovascular adverse events. Previous studies have shown that prepubescent girls had greater central augmentation pressure compared with height-matched boys. This study sought to investigate which factors contribute to the body height-independent sexual differences in central arterial wave reflection observed in childhood. Read More

    Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation.
    Clin Exp Pharmacol Physiol 2017 Sep 30. Epub 2017 Sep 30.
    Center for Disease Control and Prevention of Baoji City, 68 XiBao Road, Baoji City, 721006, Shanxi Province, PR China.
    It is well-documented that nicotine, the main active ingredient in cigarettes, results in endothelial cell injury in numerous diseases. However, whether nicotine plays a crucial role in endothelial cell injury in diabetes and the exact molecular mechanism that mediates this process have not been fully elucidated. The current study aimed to investigate the effects of nicotine on endothelial cell injury in diabetes and the specific molecular mechanism by which it plays a role. Read More

    Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts.
    Clin Exp Pharmacol Physiol 2017 Sep 26. Epub 2017 Sep 26.
    Physiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG.
    Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype. However, the cumulative effect of this with advancing age and its electrocardiographic basis has not been previously studied. Read More

    Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats.
    Clin Exp Pharmacol Physiol 2017 Sep 26. Epub 2017 Sep 26.
    Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
    Spexin is a central modulator of nociception. The aim of the present study was to investigate the effect of intra hippocampal CA3 (IHCA3) injection of spexin and spexin-progesterone co-administration on pain sensitivity in ovariectomized rat. Thirty-five adult female rats were divided into five groups. Read More

    The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.
    Clin Exp Pharmacol Physiol 2017 Sep 26. Epub 2017 Sep 26.
    Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey.
    Spleen tyrosine kinase (Syk), a non-receptor tyrosine kinase, plays an important role in allergic diseases and inflammation. Syk triggers several intracellular signalling cascades including Toll-like receptor signalling to activate inflammatory responses following fungal infection but the role of this enzyme in zymosan (ZYM)-induced non-septic shock and its impacts on hypotension and inflammation in rats is not well understood. This study was conducted to determine the effects of Syk inhibition on ZYM-induced alterations in the expression and/or activities of Syk, inhibitor ĸB (IĸB)-α, and nuclear factor-ĸB (NF-ĸB) p65. Read More

    RhPDCD5 combined with dexamethasone increases antitumor activity in multiple myeloma partially via inhibiting the Wnt signalling pathway.
    Clin Exp Pharmacol Physiol 2017 Sep 25. Epub 2017 Sep 25.
    Department of Hematology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
    Multiple myeloma (MM) is one of the most common hematological malignancies and characterized by the clonal accumulation of malignant plasma cells. Significant progress has been made in MM treatment recently, while MM still remains incurable. Our previous studies showed that the recombined human programmed cell death 5 (rhPDCD5) can promote MM apoptosis induced by dexamethasone (Dex). Read More

    Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension.
    Clin Exp Pharmacol Physiol 2017 Sep 25. Epub 2017 Sep 25.
    Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
    Apelin receptors (APJ) cross-talk with other G-protein-coupled receptors. However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear. Renovascular hypertension was induced by placing a Plexiglas clip on the left kidney of rats. Read More

    Efficacy and safety of ticagrelor in patients with acute coronary syndrome: a meta-analysis of randomized controlled trials.
    Clin Exp Pharmacol Physiol 2017 Sep 25. Epub 2017 Sep 25.
    Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, #126 Wenzhou Road, Hangzhou, Zhejiang Province, 310015, China.
    Acute coronary syndrome (ACS) is a dangerous and urgent clinical pattern of coronary artery disease. Aspirin and adenosine diphosphate P2Y12 receptor antagonists are the standard dual anti-platelet therapy for patients with ACS. Ticagrelor is a new oral antagonist of the adenosine diphosphate P2Y12 receptor. Read More

    Co-Ingestion of Aspirin and Acetaminophen Promoting Fulminant Liver Failure: A Critical Review of Reye Syndrome in the Current Perspective at the Dawn of the 21(st) Century.
    Clin Exp Pharmacol Physiol 2017 Sep 25. Epub 2017 Sep 25.
    Dept. of Lab. Medicine & Pathology,, University of Alberta, Edmonton, AB, Canada.
    In the pediatric population, there is some evidence of possible interaction, synergism, and co-toxicity of aspirin and acetaminophen. The toxicity of salicylates such as aspirin in this population is well known and documented, specifically in the form of Reye syndrome. The possible toxic synergism with aspirin and acetaminophen, however, is not previously described; though case reports suggest such co-toxicities with low levels of aspirin and other compounds can exist. Read More

    Inhibitory effect of the tricyclic antidepressant amitriptyline on voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells.
    Clin Exp Pharmacol Physiol 2017 Sep 25. Epub 2017 Sep 25.
    Department of Physiology, Kangwon National University School of Medicine, Chuncheon, South Korea.
    Amitriptyline, a tricyclic antidepressant (TCA) drug, is widely used in treatment of psychiatric disorders. However, the side effects of amitriptyline on vascular K(+) channels remain to be determined. Therefore, we investigated the effect of the tricyclic antidepressant and serotonin reuptake inhibitor amitriptyline on voltage-dependent K(+) (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells, using the whole-cell patch clamp technique. Read More

    Morphine hyposensitivity in streptozotocin-diabetic rats: Reversal by dietary l-arginine treatment.
    Clin Exp Pharmacol Physiol 2017 Sep 19. Epub 2017 Sep 19.
    School of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Qld, Australia.
    Painful diabetic neuropathy (PDN) is a long-term complication of diabetes. Defining symptoms include mechanical allodynia (pain due to light pressure or touch) and morphine hyposensitivity. In our previous work using the streptozotocin (STZ)-diabetic rat model of PDN, morphine hyposensitivity developed in a temporal manner with efficacy abolished at 3 months post-STZ and maintained for 6 months post-STZ. Read More

    MiR-30a-5p ameliorates spinal cord injury-induced inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling.
    Clin Exp Pharmacol Physiol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Orthopedics, School of Medicine, South Campus, Renji Hospital, Shanghai JiaoTong University, Shanghai, China.
    Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. Read More

    (-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells.
    Clin Exp Pharmacol Physiol 2017 Sep 19. Epub 2017 Sep 19.
    Laboratory of Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Epigallocatechin-3-gallate (EGCG) is a type of catechin. It exhibits excellent antioxidant effects and anti-tumour activities for cancer chemoprevention. The mechanism of anti-tumour effects of EGCG on different cancers has been studied for the past few decades, but remains controversial. Read More

    Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus.
    Clin Exp Pharmacol Physiol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Medicine, The University of Melbourne, Melbourne, Vic., Australia.
    Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and clinic blood pressure measurement. In this cross-sectional study, we aimed to investigate the relationship between 24 hour urinary sodium and potassium excretion, and their ratio, with 24 hour ambulatory blood pressure parameters including nocturnal blood pressure dipping in patients with type 1 and 2 diabetes. We report that in 116 patients with diabetes, systolic blood pressure was significantly predicted by the time of day, age, the interaction between dipping status with time, and 24 hour urinary sodium-to-potassium ratio (R(2)  = 0. Read More

    Association of serum osteocalcin levels with major adverse cardiovascular events: A 4.4-year retrospective cohort study.
    Clin Exp Pharmacol Physiol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai, China.
    We investigated whether the serum osteocalcin levels at baseline were associated with the incidence of major adverse cardiovascular events (MACE) in a population-based retrospective cohort study of Chinese subjects. Coronary angiography was used to diagnose coronary artery disease (CAD). Survival curves were analyzed by performing log-rank tests with Kaplan-Meier figures. Read More

    C1q/TNF-related protein 9 improves the anti-contractile effects of perivascular adipose tissue via the AMPK-eNOS pathway in diet-induced obese mice.
    Clin Exp Pharmacol Physiol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China.
    The anti-contractile property of perivascular adipose tissue (PVAT) is abolished through an endothelium-dependent pathway in obesity. C1q/tumor necrosis factor-related protein (CTRP)9 improved endothelial function by promoting endothelium-dependent vasodilatation. The aims of this study were to investigate whether CTRP9 improves the anti-contractile effect of PVAT and protects against PVAT dysfunction in obese mice. Read More

    The basis of differences in thermodynamic efficiency among skeletal muscles.
    Clin Exp Pharmacol Physiol 2017 Dec 16;44(12):1279-1286. Epub 2017 Oct 16.
    Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
    Muscles convert chemical free energy into mechanical work. The energy conversion occurs in 2 steps. First, free energy obtained from oxidation of metabolic substrates (ΔGS ) is transferred to ATP and, second, free energy from ATP hydrolysis (ΔGATP ) is converted into work by myosin cross-bridges. Read More

    Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.
    Clin Exp Pharmacol Physiol 2017 Aug 29. Epub 2017 Aug 29.
    Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
    Curcumin, an active phenolic agent extract from the Curcuma longa, exhibits excellent anti-cancer, anti-inflammation, and neuroprotective effects. We aimed to investigate the anti-influenza role of curcumin in vitro and in vivo. The effect of curcumin on replication of influenza A virus (IAV) was examined in human lung cancer cell line A549, as well as in a mouse model. Read More

    Blockade of 5-HT3 receptors with granisetron does not affect trigeminothalamic nociceptive transmission in rats: Implication for migraine.
    Clin Exp Pharmacol Physiol 2017 Aug 29. Epub 2017 Aug 29.
    Department of Neuropharmacology, Valdman Institute of Pharmacology, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
    One way to expand the existing range of anti-migraine drugs seems to be the search for pharmacological agents with anti-cephalalgic properties among medicines approved for clinical indications other than migraine. Numerous experimental and clinical data imply that selective serotonin 5-HT3 receptor antagonists can be considered as potential anti-migraine agents. Therefore, the objective of our work was to examine the impact of selective 5-HT3 receptor blockade with granisetron on migraine-related nociceptive transmission within the spinal trigeminal nucleus (STN) and the ventroposteromedial nucleus of the thalamus (VPM). Read More

    (-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease.
    Clin Exp Pharmacol Physiol 2017 Dec 3;44(12):1180-1191. Epub 2017 Oct 3.
    Department of Tea Science, Zhejiang University, Hangzhou, China.
    Non-alcoholic fatty liver disease (NAFLD) and associated advanced liver diseases have become prevalent conditions in many countries and are associated with increased mortality. Gene expression profiles in NAFLD have been examined recently but changes in expression elicited by chemical compound treatments have not been investigated. Since (-)-Epigallocatechin-3-gallate (EGCG) and atorvastatin (ATST) exhibit similar efficacy in NAFLD models, we reasoned that some common key genes might alter after treatment of EGCG and ATST. Read More

    Pharmacological modulation of C-X-C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischaemia-reperfusion injury.
    Clin Exp Pharmacol Physiol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Surgery, Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA.
    Activation of C-X-C motif chemokine receptor 4 (CXCR4) has been reported to result in lung protective effects in various experimental models. The effects of pharmacological CXCR4 modulation on the development of acute respiratory distress syndrome (ARDS) after lung injury, however, are unknown. Thus, we studied whether blockade and activation of CXCR4 influences development of ARDS in a unilateral lung ischaemia-reperfusion injury rat model. Read More

    Celecoxib inhibits osteoblast differentiation independent of cyclooxygenase activity.
    Clin Exp Pharmacol Physiol 2017 Aug 16. Epub 2017 Aug 16.
    Division of Applied Pharmacology, Department of Health Promotion, Kyushu Dental University, Kitakyushu, Japan.
    Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects primarily by inhibiting the activity of cyclooxygenase (COX), thus suppressing prostaglandin synthesis. Some NSAIDs are known to perform functions other than pain control, such as suppressing tumour cell growth, independent of their COX-inhibiting activity. To identify NSAIDs with COX-independent activity, we examined various NSAIDs for their ability to inhibit osteoblastic differentiation using the mouse pre-osteoblast cell line MC3T3-E1. Read More

    Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: Comparison with light microscopy.
    Clin Exp Pharmacol Physiol 2017 Dec 5;44(12):1241-1253. Epub 2017 Sep 5.
    Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Vic., Australia.
    We assessed the utility of synchrotron-radiation micro-computed tomography (micro-CT) for quantification of the radial geometry of the renal cortical vasculature. The kidneys of nine rats and six rabbits were perfusion fixed and the renal circulation filled with Microfil. In order to assess shrinkage of Microfil, rat kidneys were imaged at the Australian Synchrotron immediately upon tissue preparation and then post fixed in paraformaldehyde and reimaged 24 hours later. Read More

    5-HT modulates the rat mesenteric vasopressor outflow by 5-HT1D sympatholytic receptors.
    Clin Exp Pharmacol Physiol 2017 Dec 18;44(12):1224-1231. Epub 2017 Sep 18.
    Laboratory of Pharmacology, Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.
    5-hydroxytryptamine (5-HT) modulates noradrenergic activity in different cardiovascular territories, but its effect on the mesenteric vasopressor outflow has not yet been clarified. This study investigated the in vivo serotonergic influence, characterizing 5-HT receptors implicated, in sympathetic innervation of mesenteric vasculature. Wistar rats were anaesthetised and prepared for the in situ autoperfused rat mesentery, monitoring systemic blood pressure (SBP), heart rate (HR) and mesenteric perfusion pressure (MPP). Read More

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