6,693 results match your criteria Clinical and Experimental Pharmacology and Physiology[Journal]


Pharmacogenomics guidelines: current status and future development.

Clin Exp Pharmacol Physiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Dermatology, Xiangya Hospital, Central South University and Hunan Key Laboratory of Skin Cancer and psoriasis, Central South University, Changsha, 410008, Hunan, China.

Genetic polymorphisms impact biological responses to drugs. Current pharmacogenomics guidelines formulated by different countries, such as CPIC, DPWG, CPNDS, and RNPGx, play important roles in clinical practices. However, the drafting standards for these guidelines vary, resulting in differences in recommendations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13097DOI Listing
April 2019
1 Read

Could Hepatitis B Vaccine Act as An Adjuvant to Lower Risk and Relapses of Cancer?

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV)-could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumor activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13096DOI Listing
April 2019
1 Read

Metabolomics Revealed Decreased Level of Omega-3 PUFA-derived Protective Eicosanoids in Pregnant Women with Pre-eclampsia.

Clin Exp Pharmacol Physiol 2019 Apr 15. Epub 2019 Apr 15.

Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China.

Pre-eclampsia (PE) is considered a leading cause of mortality and morbidity in pregnant women worldwide. Eicosanoids derived from polyunsaturated fatty acids (PUFAs) and their metabolites might play an important role in the occurrence and development of PE. Omega-3 PUFAs are nutrients that are popular supplements for pregnant women and can reduce blood pressure. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13095DOI Listing
April 2019
3 Reads

KCNQ1OT1, HIF1A-AS2 and APOA1-AS are Promising Novel Biomarkers for Diagnosis of Coronary Artery Disease.

Clin Exp Pharmacol Physiol 2019 Apr 2. Epub 2019 Apr 2.

Institute for Translational Medicine, Qingdao University, Qingdao, 266021, P.R.China.

This study aimed to evaluate the potential of long noncoding RNAs (lncRNAs) as biomarkers for coronary artery disease (CAD). We measured the levels of 3 atherosclerosis- or cardiac-related lncRNAs in peripheral blood monocyte cells (PBMCs) from 20 CAD patients and 20 non-CAD control participants using real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) methods. We found that the levels of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) and apolipoprotein A-1 antisense RNA (APOA1-AS) were significantly increased in CAD patients (KCNQ1OT1 increased by 2. Read More

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http://dx.doi.org/10.1111/1440-1681.13094DOI Listing
April 2019
3 Reads

Nitric oxide modulates μ-opioid receptor function in vitro.

Clin Exp Pharmacol Physiol 2019 Apr 1. Epub 2019 Apr 1.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that develops as a consequence of prolonged hyperglycaemia-induced injury to the long nerves. Apart from pain, PDN is also characterized by morphine hyposensitivity. Intriguingly, in streptozotocin (STZ)-induced diabetic rats exhibiting marked morphine hyposensitivity, dietary administration of the nitric oxide (NO) precursor, L-arginine at 1 g/d, progressively rescued morphine efficacy and potency over an 8-week treatment period. Read More

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http://dx.doi.org/10.1111/1440-1681.13091DOI Listing
April 2019
3 Reads

Low KISS1 expression predicts poor prognosis for patients with colorectal cancer: a meta-analysis.

Clin Exp Pharmacol Physiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacy, Hefei Fourth People's Hospital, Hefei, Anhui, China.

KISS1 and KISS1R, a novel pair of metastasis suppressors, are likely to be associated with the prognosis of colorectal cancer (CRC). Here, a meta-analysis was performed to study the role of KISS1 and KISS1R in CRC. Heterogeneity, stability and publication bias were all estimated. Read More

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http://dx.doi.org/10.1111/1440-1681.13093DOI Listing

Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review.

Clin Exp Pharmacol Physiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.

Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is more common in women of all ages and older men. Due to multi-drug resistant strains and high recurrence rate, UTI has become a major socioeconomic burden. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13092DOI Listing
April 2019
9 Reads

Effect of pretreatment with intracerebroventricular injection of minocycline on morphine-induced memory impairment in passive avoidance test: role of P-CREB and c-Fos expression in the dorsal hippocampus and basolateral amygdala regions.

Clin Exp Pharmacol Physiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Minocycline as a member of tetracycline family is a lipophilic broad-spectrum antibiotic, which can display some non-antibiotic properties such as antioxidant, antiapoptosis, neuroprotection and modulation of pharmacological traits of drugs of abuse (ie., reward, sensitization and/or analgesia). Thus, the aim of the present study was to investigate the effect of Intracerebroventricular (ICV) injection of minocycline on morphine-induced memory impairment and motor function in male Wistar rats. Read More

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http://dx.doi.org/10.1111/1440-1681.13090DOI Listing

Different effects of Wnt/β-catenin activation and parathyroid hormone on diaphyseal and metaphyseal in the early phase of femur bone healing of mice.

Clin Exp Pharmacol Physiol 2019 Mar 25. Epub 2019 Mar 25.

State Key Laboratory of Trauma, Burn and Combined injury, Department of War Wound Rescue Skills Training, Base of Army Health Service Training, Army Medical University, Chongqing, China.

Parathyroid hormone (PTH) and agents related to the manipulation of Wnt/β-catenin signalling are two promising anabolic anti-osteoporotic therapies that have been shown to promote the healing of bone fractures. Now, it is widely accepted that cortical bone and trabecular bone are two different compartments, and should be treated as separate compartments in pathological processes, such as fracture healing. It is currently unknown whether PTH and the activation of β-catenin signalling would demonstrate different effects on cortical bone and trabecular bone healing. Read More

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http://dx.doi.org/10.1111/1440-1681.13088DOI Listing

Mechanisms of U46619-induced contraction in mouse intrarenal artery.

Clin Exp Pharmacol Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangzhou, China.

Thromboxane A (TXA ) has been implicated in the pathogenesis of vascular complications, but the underlying mechanism remains unclear. The contraction of renal arterial rings in mice was measured by a Multi Myograph System. The intracellular calcium concentration ([Ca ] ) in vascular smooth muscle cells (VSMCs) was obtained by using a fluo-4/AM dye and a confocal laser scanning microscopy. Read More

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http://dx.doi.org/10.1111/1440-1681.13087DOI Listing
March 2019
2 Reads

Non-IgE mediated hypersensitivity induced by multivitamins containing Tween-80.

Clin Exp Pharmacol Physiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Multivitamins has been widely used for years. Adverse reactions, especially hypersensitivity, to multivitamins are becoming noteworthy. However, the classification of hypersensitivity is confusing, and the trigger is unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13089DOI Listing
March 2019
2 Reads

A Randomized, Controlled, Phase II Clinical Trial of β-D-Mannuronic Acid (M2000) in Pre-surgical Breast Cancer Patients at Early Stage (T1-T2).

Clin Exp Pharmacol Physiol 2019 Mar 18. Epub 2019 Mar 18.

Department of Immunology, School of Public Health, Tehran University of Medical Science, Tehran, Iran.

Following the potent efficacy of β-D-Mannuronic acid in breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in this present clinical trial. The Study was an 8 weeks randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in 48 pre-surgical breast cancer patients. Patients who had breast cancer at early stage, with invasive ductal carcinoma, were placed on a waiting-list for surgery and were allocated. Read More

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http://dx.doi.org/10.1111/1440-1681.13086DOI Listing
March 2019
2 Reads

A novel berberine-metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats.

Clin Exp Pharmacol Physiol 2019 Mar 18. Epub 2019 Mar 18.

Academy of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

In this study, we investigated the biological activities of a novel berberine-metformin hybrid compound (BMH473) as an anti-diabetic agent. BMH473 exhibited significant anti-hyperglycaemic and anti-hyperlipidaemic effects on T2DM rats. In white adipose tissue, BMH473 reduced the perirenal and epididymal adipose tissue mass and modulated the lesions in perirenal adipose tissue, by inhibiting the protein expressions of PPAR-Ɣ, C/EBP-α and SREBP-1c as well as the mRNA expressions of lipogenic genes. Read More

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http://dx.doi.org/10.1111/1440-1681.13085DOI Listing

Functional activation of Gα protein via α -adrenoceptor in rat cerebral cortical membranes.

Clin Exp Pharmacol Physiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan.

Although it is recognized that α -adrenoceptors are coupled to diverse intracellular signalling pathways, its primary transduction mechanisms are evoked by activating phospholipase C in the cell membrane through Gα , resulting in production of inositol 1,4,5-trisphosphate and diacylglycerol. However, there have been few studies that indicate directly the involvement of Gα proteins in this signalling pathway in the central nervous system. In the current study, we tried to pharmacologically characterize (-)-adrenaline-stimulated [ S]GTPγS binding to Gα in rat brain membranes. Read More

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http://dx.doi.org/10.1111/1440-1681.13084DOI Listing

Lanatoside C protects mice against bleomycin-induced pulmonary fibrosis through suppression of fibroblast proliferation and differentiation.

Clin Exp Pharmacol Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.

It has been established that lanatoside C, a FDA-approved cardiac glycoside, reduces proliferation of cancer cell lines. The proliferation of fibroblasts is critical to the pathogenesis of pulmonary fibrosis (PF), a progressive and fatal fibrotic lung disease lacking effective treatment. In this study we have investigated the impact of lanatoside C on a bleomycin (BLM)-induced mouse model of PF and through the evaluation of fibroblast proliferation and activation in vitro. Read More

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http://dx.doi.org/10.1111/1440-1681.13081DOI Listing
March 2019
1 Read

High expression of SPAG5 sustains the malignant growth and invasion of breast cancer cells through the activation of Wnt/β-catenin signalling.

Clin Exp Pharmacol Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Ultrasound, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China.

Sperm-associated antigen 5 (SPAG5) has currently emerged as a novel oncogene in various cancers. High expression of SPAG5 has been frequently detected in breast cancer. However, the biological function and regulatory mechanism of SPAG5 in breast cancer remain unclear. Read More

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http://dx.doi.org/10.1111/1440-1681.13082DOI Listing
March 2019
3 Reads

Acid sphingomyelinase mediates the noise-induced liver disorder in mice.

Clin Exp Pharmacol Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Aerospace Hygiene, Fourth Military Medical University, Xi'an, Shaanxi, China.

Noise-induced structural and functional disorder of the liver has been realized, but the underlying mechanism remains to be characterized, which has limited the introduction of precautious measures. Over-activation of acid sphingomyelinase (ASM)/ceramide (Cer) pathway takes centre stage in hepatocyte injury entailed by various stimulus. We aimed to investigate whether it mediated the noise elicited liver disorder on infrastructure, lipid metabolism, apoptosis, and oxidative stress. Read More

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http://dx.doi.org/10.1111/1440-1681.13083DOI Listing
March 2019
2 Reads

MicroRNA-652-3p promotes the proliferation and invasion of the trophoblast HTR-8/SVneo cell line by targeting homeobox A9 to modulate the expression of ephrin receptor B4.

Clin Exp Pharmacol Physiol 2019 Mar 6. Epub 2019 Mar 6.

Department of Obstetrics, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

MicroRNAs (miRNAs) are emerging as novel modulators in the pathogenesis of preeclampsia (PE). Multiple miRNAs have been shown to regulate the proliferation and invasion of trophoblast cells, which play a critical role in successful pregnancies. miR-652-3p has been identified as a novel disease-associated miRNA that is dysregulated in various pathological processes. Read More

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http://dx.doi.org/10.1111/1440-1681.13080DOI Listing
March 2019
1 Read

P2X7 receptor in cardiovascular disease: The heart side.

Clin Exp Pharmacol Physiol 2019 Mar 4. Epub 2019 Mar 4.

Department of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, Texas.

The P2X7 receptor is a ligand-gated purinergic receptor activated by extracellular ATP. The receptor is highly expressed in immune cells and in the brain, and, upon activation, the P2X7 receptor allows a cation flux, leading to the distinct activation of intracellular signalling pathways as the secretion of pro-inflammatory cytokines, and modulation of cell survival. Through these molecular mechanisms, P2X7 is known to play important roles in physiology and pathophysiology of a wide spectrum of diseases, including cancer, inflammatory diseases, neurological, respiratory and more recently cardiovascular diseases. Read More

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http://doi.wiley.com/10.1111/1440-1681.13079
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http://dx.doi.org/10.1111/1440-1681.13079DOI Listing
March 2019
8 Reads

Pharmacokinetics, tissue distribution, plasma protein binding, and metabolism study of mefunidone, a novel pirfenidone derivative.

Clin Exp Pharmacol Physiol 2019 May 1;46(5):465-474. Epub 2019 Apr 1.

School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.

Mefunidone (MFD), a novel derivation of pirfenidone (PFD), exhibits promising anti-renal fibrosis activity. To avoid early development failures and attrition in clinical phase 1, an evaluation of the preclinical pharmacokinetic (PK) properties of MFD was conducted in this study. The absolute bioavailability was evaluated in Sprague Dawley rats and cynomolgus monkeys, who received an intragastric or intravenous administration at the dose of 31. Read More

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http://dx.doi.org/10.1111/1440-1681.13078DOI Listing
May 2019
1 Read

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Clin Exp Pharmacol Physiol 2019 May 25;46(5):456-464. Epub 2019 Mar 25.

Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

Glomerular crescent formation is a hallmark of rapidly progressive forms of glomerulonephritis. Thrombosis and macrophage infiltration are features of crescent formation in human and experimental kidney disease. Protease-activated receptor-2 (PAR-2) is a G-protein coupled receptor that links coagulation and inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13077DOI Listing
May 2019
3 Reads

Effect of hippotherapy on gait symmetry in children with cerebral palsy: A pilot study.

Clin Exp Pharmacol Physiol 2019 May 24;46(5):506-509. Epub 2019 Mar 24.

Faculty of Medical Technology, Teikyo University, Utsunomiya, Japan.

We aimed to investigate the effect of hippotherapy on gait symmetry in children with cerebral palsy (CP). Twelve children with Gross Motor Function Classification System (GMFCS) levels II-IV received weekly hippotherapy lesson for 1 year. Gait analyses were performed during a 5-m walking test, using a portable, tri-axial accelerometer-based motion recorder. Read More

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http://dx.doi.org/10.1111/1440-1681.13076DOI Listing
May 2019
1 Read

Ivabradine reversed nondipping heart rate in rats with l-NAME-induced hypertension.

Clin Exp Pharmacol Physiol 2019 Feb 21. Epub 2019 Feb 21.

Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

We hypothesized that decreasing elevated night-time heart rate (HR) in hypertension by administering a bradycardic agent (ivabradine) at bedtime could bring cardiovascular benefit. Since rats are nocturnal animals, they exhibit circadian rhythms phase-shifted relative to humans. Sixty-six Wistar rats were divided into non-diseased controls and rats with l-NAME-induced hypertension to compare the haemodynamic effects of daytime-dosed and night-time-dosed ivabradine. Read More

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http://dx.doi.org/10.1111/1440-1681.13075DOI Listing
February 2019
1 Read

Resveratrol protects against hepatic insulin resistance in a rat's model of non-alcoholic fatty liver disease by down-regulation of GPAT-1 and DGAT2 expression and inhibition of PKC membranous translocation.

Clin Exp Pharmacol Physiol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pathology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.

Non-alcoholic fatty liver disease (NAFLD) is associated with hepatic insulin resistance (IR). Resveratrol (RES) a potent hypolipidemic dietary polyphenol has been identified for its ability to prevent hepatic steatosis and hepatic IR in high-fat diet (HFD)-fed murine models of NAFLD. In the present study, we have carried an in vivo animal experiment to identify a novel mechanism for RES protective action. Read More

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http://dx.doi.org/10.1111/1440-1681.13074DOI Listing
February 2019

NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases.

Clin Exp Pharmacol Physiol 2019 May 12;46(5):413-422. Epub 2019 Mar 12.

Acıbadem Healthcare Services, Labgen Genetic Diagnosis Center, Istanbul, Turkey.

Ageing can be defined as the progressive failure of repair and maintenance systems with a consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These various types of damage promote ageing by driving cellular senescence and apoptosis. The nuclear factor-kappa B (NF-kB) pathway is one of the key mediators of ageing and this pathway is activated by genotoxic, oxidative and inflammatory stress, and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell-cycle progression, and inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13073DOI Listing
May 2019
4 Reads

Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles.

Clin Exp Pharmacol Physiol 2019 May 7;46(5):444-455. Epub 2019 Mar 7.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi-City, Chiba, Japan.

We investigated the potential augmenting effects of 19 clinically available antidepressants on noradrenaline (NA)-induced contractions in guinea pig urethra smooth muscle (USM). Concentration-response curves for NA-induced contractions in guinea pig USM strips were obtained in the absence or presence of selected antidepressants. Desipramine, an active metabolite of imipramine, produced a contraction and potentiated NA-induced contraction at the distal urethra without affecting the proximal urethra. Read More

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http://dx.doi.org/10.1111/1440-1681.13072DOI Listing

Enhanced antitumour activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma.

Clin Exp Pharmacol Physiol 2019 May 12;46(5):496-505. Epub 2019 Mar 12.

Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah, Saudi Arabia.

Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Nanoparticle drug delivery systems are a novel way of improving therapeutics and also improving the absorption and specificity of drugs towards tumour cells. Read More

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http://dx.doi.org/10.1111/1440-1681.13071DOI Listing
May 2019
3 Reads

Methenamine's journey of 160 years: Repurposal of an old urinary antiseptic for treatment and hypoxic radiosensitization of cancers and glioblastoma.

Clin Exp Pharmacol Physiol 2019 May 27;46(5):407-412. Epub 2019 Feb 27.

Department of Neurosurgery, Acibadem University, Istanbul, Turkey.

Methenamine (hexamethylenetetramine, hexamine, urotropine) is a compound discovered in 1859, which is still currently being used as a urinary antiseptic. Methenamine is highly soluble in water and polar solvents, and its molecular constitution is similar to adamantane compounds with tetrahedral cage like structure. In acidic conditions, methenamine decomposes to formaldehyde and ammonia. Read More

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http://dx.doi.org/10.1111/1440-1681.13070DOI Listing
May 2019
3 Reads

Investigation of anti-inflammatory, nitric oxide donating, vasorelaxation and ulcerogenic activities of 1, 3-diphenylprop-2-en-1-one derivatives in animal models.

Clin Exp Pharmacol Physiol 2019 May 6;46(5):483-495. Epub 2019 Mar 6.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, India.

The main aim of this work is to find out novel chemical moieties with potent anti-inflammatory and vasorelaxant activities with reduced gastric toxicities. For fulfilling the above aim, here we investigated novel chalcones (1, 3-diphenylprop-2-en-1-one derivatives) with nitric oxide (NO) and hydrogen sulphide (H S) donating potency for anti-inflammatory activity by carrageenan-induced rat paw oedema. These molecules then further evaluated for in-vitro NO-releasing potency and vasorelaxation effect on isolated adult goat aortic tissue. Read More

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http://dx.doi.org/10.1111/1440-1681.13069DOI Listing

Corrigendum.

Authors:

Clin Exp Pharmacol Physiol 2019 Feb;46(2):194

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http://dx.doi.org/10.1111/1440-1681.13055DOI Listing
February 2019

Successful intravenous Alteplase for a centenarian woman with acute ischaemic stroke.

Clin Exp Pharmacol Physiol 2019 May 1;46(5):423-426. Epub 2019 Apr 1.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

We report a case of a 105-year-old woman who was treated with Alteplase for acute ischaemic stroke (AIS). On arrival, this centenarian woman had sudden-onset aphasia and right-sided hemiparesis, her baseline National Institutes of Health Stroke Scale (NIHSS) score was 21. An acute noncontrast brain CT scan showed only mild white matter disease. Read More

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http://dx.doi.org/10.1111/1440-1681.13067DOI Listing
May 2019
2 Reads

Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension.

Clin Exp Pharmacol Physiol 2019 May 25;46(5):427-434. Epub 2019 Feb 25.

First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan.

Many hypertensive animal models have been developed and used to elucidate the pathophysiology of hypertension and to develop antihypertensive drugs. Among them, the spontaneous hypertensive rat (SHR), deoxycorticosterone acetate (DOCA)-treated and high salt intake rat (DOCA-salt), and high sodium-fed Dahl salt-sensitive rat (HS) models are commonly used. Multiple studies have been conducted, however, elevation in blood pressure in these models due to the reactivity of adrenergic vasoconstriction has not been well characterized in a centralized experiment. Read More

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http://dx.doi.org/10.1111/1440-1681.13068DOI Listing
May 2019
1 Read

Vancomycin dosing, monitoring and toxicity: Critical review of the clinical practice.

Clin Exp Pharmacol Physiol 2019 Jan 9. Epub 2019 Jan 9.

Botucatu School of Medicine, University São Paulo State-UNESP, Botucatu, Brazil.

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis may lead to multiple organ failure; it is considered a risk factor for the development of acute kidney injury (AKI), with an overall mortality rate of around 45%, which can reach the surprising rate of 70% with the combination of AKI and sepsis. Read More

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http://dx.doi.org/10.1111/1440-1681.13066DOI Listing
January 2019
5 Reads

Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid-induced epileptic rats by antioxidant activity and NLRP3/caspase-1 pathway inhibition.

Clin Exp Pharmacol Physiol 2019 Jan 8. Epub 2019 Jan 8.

Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human. Huperzine A (Hup-A) has been reported to possess antioxidative and anti-inflammatory properties; however, its role in TLE induced by kainic acid has not been determined. The current study investigated the protective effects of Hup-A (0. Read More

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http://doi.wiley.com/10.1111/1440-1681.13064
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http://dx.doi.org/10.1111/1440-1681.13064DOI Listing
January 2019
12 Reads

Caffeine enhances activity thermogenesis and energy expenditure in rats.

Clin Exp Pharmacol Physiol 2019 May 14;46(5):475-482. Epub 2019 Feb 14.

Department of Biological Sciences, Kent State University, Kent, Ohio.

Caffeine and its derivatives have been used, alone and in combination with other phytochemicals, as weight-loss supplements. Caffeine affects several physiological and behavioural aspects of energy balance, including increasing locomotor activity. This study investigates the potential for caffeine to enhance activity thermogenesis and energy expenditure (EE) even when activity level is held constant. Read More

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http://doi.wiley.com/10.1111/1440-1681.13065
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http://dx.doi.org/10.1111/1440-1681.13065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467726PMC
May 2019
7 Reads

Effects of metoprolol, methyldopa, and nifedipine on endothelial progenitor cells in patients with gestational hypertension and preeclampsia.

Clin Exp Pharmacol Physiol 2019 Jan 7. Epub 2019 Jan 7.

Department of General Practice, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Endothelial progenitor cells (EPCs) are critical for vascular regeneration and function, but are reduced in hypertensive disorders of pregnancy. We aimed to determine the possible effects of antihypertensive drugs, such as metoprolol, methyldopa, and nifedipine, on EPC number and functions in patients with gestational hypertension and preeclampsia. We collected blood samples from 30 normal pregnant women, 67 patients with gestational hypertension and 48 patients with preeclampsia. Read More

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http://dx.doi.org/10.1111/1440-1681.13063DOI Listing
January 2019
2 Reads

Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca permeant ion channels and Ca sensitization, relaxing airway smooth muscle contraction.

Clin Exp Pharmacol Physiol 2019 Jan 4. Epub 2019 Jan 4.

Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China.

Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measurements, the examination of lung slices, imaging, and patch-clamp techniques. AZM completely inhibited acetylcholine (ACH)-induced precontraction of ASMs in animals (mice, guinea pigs, and rabbits) and humans. Read More

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http://dx.doi.org/10.1111/1440-1681.13062DOI Listing
January 2019
4 Reads

The GnRH analogues affect novel neuropeptide SMIM20/phoenixin and GPR173 receptor expressions in the female rat hypothalamic-pituitary-gonadal (HPG) axis.

Clin Exp Pharmacol Physiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

The recently discovered peptide phoenixin (PNX) and its receptor GPR173 are novel factors that exhibit a large spectrum of regulatory activity, especially when considered as a central modulator of GnRH-related hormonal control of reproductive processes. It has been already proven that GnRH agonists and antagonists can modulate peptidergic signalling in the HPG axis. Despite these findings, there is so far no information regarding the influence of treatment with GnRH analogues on SMIM20/phoenixin signalling in the hypothalamic-pituitary-gonadal axis. Read More

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http://dx.doi.org/10.1111/1440-1681.13061DOI Listing
January 2019
2 Reads

Long non-coding RNA TUG1 regulates the migration and invasion of trophoblast-like cells through sponging miR-204-5p.

Clin Exp Pharmacol Physiol 2018 Dec 21. Epub 2018 Dec 21.

Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, China.

Preeclampsia (PE) is a leading cause of maternal and perinatal death. Accumulated evidence suggests that many long non-coding RNAs (lncRNAs) are abnormally expressed in placentas from PE patients, and they may play functional roles in the development of PE. The present study aimed to investigate the functional role TUG1 in PE and explore the potential molecular mechanisms. Read More

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http://doi.wiley.com/10.1111/1440-1681.13058
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http://dx.doi.org/10.1111/1440-1681.13058DOI Listing
December 2018
12 Reads

MicroRNA let-7c-5p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide-induced inflammation via HMGA2/PI3K/Akt signal blockade.

Clin Exp Pharmacol Physiol 2018 Dec 21. Epub 2018 Dec 21.

Department of Endodontics, School of Stomatology, Jilin University, Changchun, China.

Pulpitis suppressed the level of let-7c-5p that promotes osteogenesis and bone formation by repressing HMGA2. In the current study, the function of let-7c-5p in the inflammation and osteogenesis in dental pulp stem cells (DPSCs) was explored. The level of let-7c-5p in DPSCs was up-regulated, and the cells were subjected to lipopolysaccharide (LPS) to induce inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13059DOI Listing
December 2018
5 Reads

A prospective, randomized trial of intravenous hydroxocobalamin versus noradrenaline or saline for treatment of lipopolysaccharide-induced hypotension in a swine model.

Clin Exp Pharmacol Physiol 2019 Mar;46(3):216-225

Department of Emergency Medicine, Harbor-UCLA, Torrance, California.

Early, non-clinical studies support the use of hydroxocobalamin to treat sepsis-induced hypotension, but there is no translational, large animal model. The objective of this study was to compare survival in a sepsis model where large swine had endotoxaemia induced with lipopolysaccharide (LPS) and were treated with intravenous hydroxocobalamin (HOC), noradrenaline (NA), or saline. Thirty swine (45-55 kg) were anaesthetized, intubated, and instrumented with continuous femoral and pulmonary artery pressure monitoring. Read More

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http://dx.doi.org/10.1111/1440-1681.13060DOI Listing
March 2019
3 Reads

Homogeneous orthogonal diffusion of drugs in the rat brain.

Clin Exp Pharmacol Physiol 2018 Dec 20. Epub 2018 Dec 20.

Center of Medical and Health Analysis, Peking University, Beijing, China.

The study introduced a homogeneous orthogonal diffusion model to describe the diffusion pattern of agents in the rat brain. Magnetic resonance imaging was performed post-injection of paramagnetic drugs into the caudatum of the rat brain at predetermined time intervals. The signal intensity on magnetic resonance images was converted to agents' concentration, and the standard least square method was employed to estimate the diffusion coefficients. Read More

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http://dx.doi.org/10.1111/1440-1681.13057DOI Listing
December 2018
1 Read

Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells.

Clin Exp Pharmacol Physiol 2019 Feb;46(2):105-115

Institute of Ageing Research, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Recent clinical success of immunotherapy that inhibits the negative immune regulatory pathway programmed cell death protein-1/PD-1 ligand 1 (PD-1/PD-L1) has initiated a new era in the treatment of metastatic cancer. However, greater challenges remain to treat all cancers. The molecular architecture in the immune synapse constituting positive engagements for immune activation and negative checkpoints against immune hyperactivity is regulated dynamically by interaction between proteostasis and tumour microenvironment. Read More

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http://doi.wiley.com/10.1111/1440-1681.13056
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http://dx.doi.org/10.1111/1440-1681.13056DOI Listing
February 2019
17 Reads

Increased serum levels of progranulin (PGRN) in patients with haemophilic arthropathy.

Clin Exp Pharmacol Physiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopaedics and Traumatology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.

Haemophilia A and B are rarely occurring X chromosome-linked congenital coagulation disorders dominated by spontaneous joint bleedings and chronic synovitis, leading to development of haemophilic arthropathy (HA). Progranulin (PGRN) is a growth factor with anti-inflammatory and immunomodulatory properties. PGRN is an important molecule in the pathogenesis of osteoarthritis (OA) and rheumatological disorders. Read More

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http://doi.wiley.com/10.1111/1440-1681.13054
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http://dx.doi.org/10.1111/1440-1681.13054DOI Listing
November 2018
33 Reads

First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats.

Clin Exp Pharmacol Physiol 2019 Mar 27;46(3):266-273. Epub 2018 Dec 27.

Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan.

The first dose of a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor induces osmotic diuresis and can thereby affect cardiovascular activity in hyperglycemic patients. We aimed to determine whether the first dose of the selective SGLT2 inhibitor ipragliflozin affects cardiovascular activity in non-diabetic Sprague-Dawley (SD) rats and Spontaneously Diabetic Torii (SDT) fatty rats in two studies, a urine collection study and a telemetry study. In the former study, urine was collected for 24 hours after a single oral dose of ipragliflozin. Read More

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http://doi.wiley.com/10.1111/1440-1681.13053
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http://dx.doi.org/10.1111/1440-1681.13053DOI Listing
March 2019
2 Reads

Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.

Clin Exp Pharmacol Physiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacy, Taizhou Second People's Hospital, Taizhou, China.

Parkinson's disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Cathepsin D (CathD), a soluble aspartic protease, has been reported to play an important role in neurodegenerative diseases such as PD. Read More

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http://dx.doi.org/10.1111/1440-1681.13052DOI Listing
November 2018
11 Reads

Trimebutine maleate relaxes the isolated rat thoracic aorta: The role of nitric oxide and L-type calcium channels.

Clin Exp Pharmacol Physiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.

Trimebutine maleate (TMB), a widely prescribed drug for functional gastrointestinal disorders, has been reported to regulate smooth muscle contractility by modulating multiple ion channel activities in the gastrointestinal tract. However, its action on isolated aorta has not yet been reported. The aim of the present study was to evaluate in vitro vasorelaxant properties and the underlying pharmacological mechanisms of TMB in isolated rat thoracic aortic rings. Read More

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http://doi.wiley.com/10.1111/1440-1681.13051
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http://dx.doi.org/10.1111/1440-1681.13051DOI Listing
November 2018
8 Reads

Protective effects of diphenyleneiodonium, an NADPH oxidase inhibitor, on lipopolysaccharide-induced acute lung injury.

Clin Exp Pharmacol Physiol 2019 Feb 22;46(2):153-162. Epub 2018 Nov 22.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

NADPH oxidase (NOX) plays an important role in inflammatory response by producing reactive oxygen species (ROS). The inhibition of NOX has been shown to induce anti-inflammatory effects in a few experimental models. The aim of this study was to investigate the effects of diphenyleneiodonium (DPI), a NOX inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a rat model. Read More

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http://doi.wiley.com/10.1111/1440-1681.13050
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http://dx.doi.org/10.1111/1440-1681.13050DOI Listing
February 2019
17 Reads

Inhibition of cancer stem cells promoted by Pimozide.

Clin Exp Pharmacol Physiol 2019 Feb 28;46(2):116-125. Epub 2018 Nov 28.

Department of Morphological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Over the past years, studies have described that users of antipsychotics are less likely to develop cancer than the population in general due to cytotoxic properties of this class of drugs on cancer cells. For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in melanoma, central nervous system tumours, osteosarcoma, neuroblastoma, myeloproliferative neoplasms, breast, lung, prostate, ovarian, colorectal, pancreatic, and hepatocellular carcinoma have been showed. Moreover, advantages as clinical use approved by the Food and Drug Administration (FDA), high clinical safety, low side effects, and reasonable price have stimulated the treatment with Pimozide instead of other agents. Read More

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http://doi.wiley.com/10.1111/1440-1681.13049
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http://dx.doi.org/10.1111/1440-1681.13049DOI Listing
February 2019
9 Reads

The role of galectin-3 in heart failure and cardiovascular disease.

Clin Exp Pharmacol Physiol 2019 Mar 7;46(3):197-203. Epub 2019 Jan 7.

Cardiovascular Center, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.

Galectin-3, a β-galactoside-binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in patients with cardiovascular disease. Genetic or pharmacological inhibition of galectin-3 slows down the progression of myocardial inflammation, reduces collagen production, attenuates cardiac remodelling, and ameliorates cardiac function. In this review, we summarize recent progress in research on galectin-3 as a regulatory molecule involved in cardiovascular fibrosis in HF and its potential role in the diagnosis, risk assessment and treatment of cardiovascular diseases. Read More

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http://doi.wiley.com/10.1111/1440-1681.13048
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http://dx.doi.org/10.1111/1440-1681.13048DOI Listing
March 2019
17 Reads