6,669 results match your criteria Clinical and Experimental Pharmacology and Physiology[Journal]


NF-κB as the mediator of metformin's effect on aging and age-related diseases.

Clin Exp Pharmacol Physiol 2019 Feb 12. Epub 2019 Feb 12.

Acıbadem Healthcare Services, Labgen Genetic Diagnosis Center, Istanbul, Turkey.

Aging can be defined as the progressive failure of repair and maintenance systems with a consequent accumulation of cellular damage in nucleic acids, proteins, and lipids. These various types of damage promote aging by driving cellular senescence and apoptosis. NF-kB (nuclear factor-kappa B) pathway is one of the key mediators of aging and this pathway is activated by genotoxic, oxidative and inflammatory stress, and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell cycle progression, and inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13073DOI Listing
February 2019
1 Read

Evaluation of the potentiating effects of antidepressants on the contractile response to noradrenaline in guinea pig urethra smooth muscles.

Clin Exp Pharmacol Physiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi-City, Chiba, 274-8510, Japan.

We investigated the potential augmenting effects of 19 clinically available antidepressants on noradrenaline (NA)-induced contractions in guinea pig urethra smooth muscle (USM). Concentration-response curves for NA-induced contractions in guinea pig USM strips were obtained in the absence or presence of selected antidepressants. Desipramine, an active metabolite of imipramine, produced a contraction and potentiated NA-induced contraction at the distal urethra without affecting the proximal urethra. Read More

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http://dx.doi.org/10.1111/1440-1681.13072DOI Listing
February 2019

Enhanced anti-tumor activity of doxorubicin and simvastatin combination loaded nanoemulsion treatment against a Swiss albino mouse model of Ehrlich ascites carcinoma.

Clin Exp Pharmacol Physiol 2019 Feb 6. Epub 2019 Feb 6.

Health Information Technology Department, Jeddah Community College, King Abdulaziz University, P.O. Box- 80283, Jeddah-21589, Kingdom of Saudi Arabia.

Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Nanoparticle drug delivery systems are a novel way of improving therapeutics and also improve the absorption and specificity of drugs towards tumor cells. Read More

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http://dx.doi.org/10.1111/1440-1681.13071DOI Listing
February 2019
1 Read

Methenamine's Journey of 160 Years: Repurposal of an old urinary antiseptic for treatment and hypoxic radiosensitization of cancers and glioblastoma.

Clin Exp Pharmacol Physiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Acibadem University, Istanbul, Turkey.

Methenamine (hexamethylenetetramine, hexamine, urotropine) is a compound discovered in 1859, which is still currently being used as an urinary antiseptic. Methenamine is higly soluble in water and polar solvents, and its molecular constitution is similar to adamantane compounds with tetrahedral cage like structure. At acidic conditions, methenamine decomposes to formaldehyde and ammonia. Read More

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http://dx.doi.org/10.1111/1440-1681.13070DOI Listing
February 2019
2 Reads

Investigation of Anti-inflammatory, Nitric oxide Donating, Vasorelaxation and Ulcerogenic activities of 1, 3-diphenylprop-2-en-1-one derivatives in Animal Models.

Clin Exp Pharmacol Physiol 2019 Feb 3. Epub 2019 Feb 3.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Near Chitranagri, Kolhapur-416 013, MS, India.

The main aim of this work is to find out novel chemical moieties with potent anti-inflammatory and vasorelaxant activities with reduced gastric toxicities. For fulfilling the above aim, here we investigated novel chalcones (1, 3-diphenylprop-2-en-1-one derivatives) with nitric oxide (NO) and hydrogen sulfide (H S) donating potency for anti-inflammatory activity by carrageenan-induced rat paw edema. These molecules then further evaluated for in-vitro NO-releasing potency and vasorelaxation effect on isolated adult goat aortic tissue. Read More

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http://dx.doi.org/10.1111/1440-1681.13069DOI Listing
February 2019

Corrigendum.

Authors:

Clin Exp Pharmacol Physiol 2019 Feb;46(2):194

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http://dx.doi.org/10.1111/1440-1681.13055DOI Listing
February 2019

Successful Intravenous Alteplase for a Centenarian Woman with Acute Ischaemic Stroke.

Clin Exp Pharmacol Physiol 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

We report a case of a 105-year-old woman who was treated with Alteplase for acute ischaemic stroke (AIS). On arrival, this centenarian Woman had sudden-onset aphasia and right-sided hemiparesis, her baseline National Institutes of Health Stroke Scale (NIHSS) score was 21. An acute noncontrast brain CT scan showed only mild white matter disease. Read More

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http://dx.doi.org/10.1111/1440-1681.13067DOI Listing
January 2019
1 Read

Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension.

Clin Exp Pharmacol Physiol 2019 Jan 29. Epub 2019 Jan 29.

First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan.

Many hypertensive animal models have been developed and used to elucidate the pathophysiology of hypertension and to develop antihypertensive drugs. Among them, the spontaneous hypertensive rat (SHR), deoxycorticosterone acetate (DOCA)-treated and high salt intake rat (DOCA-salt), and high sodium-fed Dahl salt-sensitive rat (HS) models are commonly used. Multiple studies have been conducted; however, elevation in blood pressure in these models due to the reactivity of adrenergic vasoconstriction has not been well characterized in a centralized experiment. Read More

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http://dx.doi.org/10.1111/1440-1681.13068DOI Listing
January 2019
1 Read

Vancomycin Dosing, Monitoring and Toxicity: Critical review of the clinical practice.

Clin Exp Pharmacol Physiol 2019 Jan 9. Epub 2019 Jan 9.

Botucatu School of Medicine, University São Paulo State-UNESP, Distrito de Rubiao Junior, without number, Botucatu, Sao Paulo, Brazil.

Vancomycin is an antibiotic used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus. In the last decades, vancomycin has been widely used in hospital environments due to the increasing incidence of sepsis and septic shock. Sepsis may lead to multiple organ failure; it is considered a risk factor for the development of acute kidney injury (AKI), with an overall mortality rate of around 45%, which can reach the surprising rate of 70% with the combination of AKI and sepsis. Read More

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http://dx.doi.org/10.1111/1440-1681.13066DOI Listing
January 2019
5 Reads

Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid-induced epileptic rats by antioxidant activity and NLRP3/caspase-1 pathway inhibition.

Clin Exp Pharmacol Physiol 2019 Jan 8. Epub 2019 Jan 8.

Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human. Huperzine A (Hup-A) has been reported to possess antioxidative and anti-inflammatory properties; however, its role in TLE induced by kainic acid has not been determined. The current study investigated the protective effects of Hup-A (0. Read More

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http://doi.wiley.com/10.1111/1440-1681.13064
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http://dx.doi.org/10.1111/1440-1681.13064DOI Listing
January 2019
5 Reads

Caffeine enhances activity thermogenesis and energy expenditure in rats.

Clin Exp Pharmacol Physiol 2019 Jan 8. Epub 2019 Jan 8.

Department of Biological Sciences, Kent State University, Kent, Ohio.

Caffeine and its derivatives have been used, alone and in combination with other phytochemicals, as weight-loss supplements. Caffeine affects several physiological and behavioural aspects of energy balance, including increasing locomotor activity. This study investigates the potential for caffeine to enhance activity thermogenesis and energy expenditure (EE) even when activity level is held constant. Read More

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http://doi.wiley.com/10.1111/1440-1681.13065
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http://dx.doi.org/10.1111/1440-1681.13065DOI Listing
January 2019
7 Reads

Effects of metoprolol, methyldopa, and nifedipine on endothelial progenitor cells in patients with gestational hypertension and preeclampsia.

Clin Exp Pharmacol Physiol 2019 Jan 7. Epub 2019 Jan 7.

Department of General Practice, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Endothelial progenitor cells (EPCs) are critical for vascular regeneration and function, but are reduced in hypertensive disorders of pregnancy. We aimed to determine the possible effects of antihypertensive drugs, such as metoprolol, methyldopa, and nifedipine, on EPC number and functions in patients with gestational hypertension and preeclampsia. We collected blood samples from 30 normal pregnant women, 67 patients with gestational hypertension and 48 patients with preeclampsia. Read More

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http://dx.doi.org/10.1111/1440-1681.13063DOI Listing
January 2019
2 Reads

Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca permeant ion channels and Ca sensitization, relaxing airway smooth muscle contraction.

Clin Exp Pharmacol Physiol 2019 Jan 4. Epub 2019 Jan 4.

Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China.

Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measurements, the examination of lung slices, imaging, and patch-clamp techniques. AZM completely inhibited acetylcholine (ACH)-induced precontraction of ASMs in animals (mice, guinea pigs, and rabbits) and humans. Read More

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http://dx.doi.org/10.1111/1440-1681.13062DOI Listing
January 2019
1 Read

The GnRH analogues affect novel neuropeptide SMIM20/phoenixin and GPR173 receptor expressions in the female rat hypothalamic-pituitary-gonadal (HPG) axis.

Clin Exp Pharmacol Physiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

The recently discovered peptide phoenixin (PNX) and its receptor GPR173 are novel factors that exhibit a large spectrum of regulatory activity, especially when considered as a central modulator of GnRH-related hormonal control of reproductive processes. It has been already proven that GnRH agonists and antagonists can modulate peptidergic signalling in the HPG axis. Despite these findings, there is so far no information regarding the influence of treatment with GnRH analogues on SMIM20/phoenixin signalling in the hypothalamic-pituitary-gonadal axis. Read More

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http://dx.doi.org/10.1111/1440-1681.13061DOI Listing
January 2019
2 Reads

Long non-coding RNA TUG1 regulates the migration and invasion of trophoblast-like cells through sponging miR-204-5p.

Clin Exp Pharmacol Physiol 2018 Dec 21. Epub 2018 Dec 21.

Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.

Preeclampsia (PE) is a leading cause of maternal and perinatal death. Accumulated evidence suggests that many long non-coding RNAs (lncRNAs) abnormally expressed in placentas from PE patients, and they may play functional roles in the development of PE. The present study aimed to investigate the functional role TUG1 in PE and explore the potential molecular mechanisms. Read More

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http://doi.wiley.com/10.1111/1440-1681.13058
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http://dx.doi.org/10.1111/1440-1681.13058DOI Listing
December 2018
6 Reads

MicroRNA let-7c-5p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide-induced inflammation via HMGA2/PI3K/Akt signal blockade.

Clin Exp Pharmacol Physiol 2018 Dec 21. Epub 2018 Dec 21.

Department of Endodontics, School of Stomatology, Jilin University, Changchun, China.

Pulpitis suppressed the level of let-7c-5p that promotes osteogenesis and bone formation by repressing HMGA2. In the current study, the function of let-7c-5p in the inflammation and osteogenesis in dental pulp stem cells (DPSCs) was explored. The level of let-7c-5p in DPSCs was up-regulated, and the cells were subjected to lipopolysaccharide (LPS) to induce inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13059DOI Listing
December 2018
1 Read

A prospective, randomized trial of intravenous hydroxocobalamin versus norepinephrine or saline for treatment of lipopolysaccharide-induced hypotension in a swine model.

Clin Exp Pharmacol Physiol 2018 Dec 21. Epub 2018 Dec 21.

Harbor-UCLA, Department of Emergency Medicine Torrance, CA, 90502.

Early, non-clinical studies support the use of hydroxocobalamin to treat sepsis-induced hypotension, but there is no translational, large animal model. The objective of this study was to compare survival in a sepsis model where large swine had endotoxaemia induced with lipopolysaccharide (LPS) and were treated with intravenous hydroxocobalamin (HOC), norepinephrine (NE), or saline. Thirty swine (45-55 kg) were anesthetized, intubated, and instrumented with continuous femoral and pulmonary artery pressure monitoring. Read More

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http://dx.doi.org/10.1111/1440-1681.13060DOI Listing
December 2018
1 Read

Homogeneous orthogonal diffusion of drugs in the rat brain.

Clin Exp Pharmacol Physiol 2018 Dec 20. Epub 2018 Dec 20.

Center of Medical and Health Analysis, Peking University, Beijing, China.

The study introduced a homogeneous orthogonal diffusion model to describe the diffusion pattern of agents in the rat brain. Magnetic resonance imaging was performed post-injection of paramagnetic drugs into the caudatum of the rat brain at predetermined time intervals. The signal intensity on magnetic resonance images was converted to agents' concentration, and the standard least square method was employed to estimate the diffusion coefficients. Read More

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http://dx.doi.org/10.1111/1440-1681.13057DOI Listing
December 2018
1 Read

Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells.

Clin Exp Pharmacol Physiol 2019 Feb;46(2):105-115

Institute of Ageing Research, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Recent clinical success of immunotherapy that inhibits the negative immune regulatory pathway programmed cell death protein-1/PD-1 ligand 1 (PD-1/PD-L1) has initiated a new era in the treatment of metastatic cancer. However, greater challenges remain to treat all cancers. The molecular architecture in the immune synapse constituting positive engagements for immune activation and negative checkpoints against immune hyperactivity is regulated dynamically by interaction between proteostasis and tumour microenvironment. Read More

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http://doi.wiley.com/10.1111/1440-1681.13056
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http://dx.doi.org/10.1111/1440-1681.13056DOI Listing
February 2019
11 Reads

Increased serum levels of progranulin (PGRN) in patients with haemophilic arthropathy.

Clin Exp Pharmacol Physiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Orthopaedics and Traumatology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.

Haemophilia A and B are rarely occurring X chromosome-linked congenital coagulation disorders dominated by spontaneous joint bleedings and chronic synovitis, leading to development of haemophilic arthropathy (HA). Progranulin (PGRN) is a growth factor with anti-inflammatory and immunomodulatory properties. PGRN is an important molecule in the pathogenesis of osteoarthritis (OA) and rheumatological disorders. Read More

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http://doi.wiley.com/10.1111/1440-1681.13054
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http://dx.doi.org/10.1111/1440-1681.13054DOI Listing
November 2018
23 Reads

First-dose effect of the SGLT2 inhibitor ipragliflozin on cardiovascular activity in spontaneously diabetic Torii fatty rats.

Clin Exp Pharmacol Physiol 2018 Nov 28. Epub 2018 Nov 28.

Drug Discovery Research, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan.

The first dose of a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor induces osmotic diuresis and can thereby affect cardiovascular activity in hyperglycemic patients. We aimed to determine whether the first dose of the selective SGLT2 inhibitor ipragliflozin affects cardiovascular activity in non-diabetic Sprague-Dawley (SD) rats and Spontaneously Diabetic Torii (SDT) fatty rats in two studies, a urine collection study and a telemetry study. In the former study, urine was collected for 24 hours after a single oral dose of ipragliflozin. Read More

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http://doi.wiley.com/10.1111/1440-1681.13053
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http://dx.doi.org/10.1111/1440-1681.13053DOI Listing
November 2018
1 Read

Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.

Clin Exp Pharmacol Physiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacy, Taizhou Second People's Hospital, Taizhou, China.

Parkinson's disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Cathepsin D (CathD), a soluble aspartic protease, has been reported to play an important role in neurodegenerative diseases such as PD. Read More

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http://dx.doi.org/10.1111/1440-1681.13052DOI Listing
November 2018
6 Reads

Trimebutine maleate relaxes the isolated rat thoracic aorta: The role of nitric oxide and L-type calcium channels.

Clin Exp Pharmacol Physiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.

Trimebutine maleate (TMB), a widely prescribed drug for functional gastrointestinal disorders, has been reported to regulate smooth muscle contractility by modulating multiple ion channel activities in the gastrointestinal tract. However, its action on isolated aorta has not yet been reported. The aim of the present study was to evaluate in vitro vasorelaxant properties and the underlying pharmacological mechanisms of TMB in isolated rat thoracic aortic rings. Read More

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http://doi.wiley.com/10.1111/1440-1681.13051
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http://dx.doi.org/10.1111/1440-1681.13051DOI Listing
November 2018
7 Reads

Protective effects of diphenyleneiodonium, an NADPH oxidase inhibitor, on lipopolysaccharide-induced acute lung injury.

Clin Exp Pharmacol Physiol 2019 Feb 22;46(2):153-162. Epub 2018 Nov 22.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

NADPH oxidase (NOX) plays an important role in inflammatory response by producing reactive oxygen species (ROS). The inhibition of NOX has been shown to induce anti-inflammatory effects in a few experimental models. The aim of this study was to investigate the effects of diphenyleneiodonium (DPI), a NOX inhibitor, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a rat model. Read More

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http://doi.wiley.com/10.1111/1440-1681.13050
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http://dx.doi.org/10.1111/1440-1681.13050DOI Listing
February 2019
12 Reads

Inhibition of cancer stem cells promoted by Pimozide.

Clin Exp Pharmacol Physiol 2019 Feb 28;46(2):116-125. Epub 2018 Nov 28.

Department of Morphological Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Over the past years, studies have described that users of antipsychotics are less likely to develop cancer than the population in general due to cytotoxic properties of this class of drugs on cancer cells. For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in melanoma, central nervous system tumours, osteosarcoma, neuroblastoma, myeloproliferative neoplasms, breast, lung, prostate, ovarian, colorectal, pancreatic, and hepatocellular carcinoma have been showed. Moreover, advantages as clinical use approved by the Food and Drug Administration (FDA), high clinical safety, low side effects, and reasonable price have stimulated the treatment with Pimozide instead of other agents. Read More

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http://doi.wiley.com/10.1111/1440-1681.13049
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http://dx.doi.org/10.1111/1440-1681.13049DOI Listing
February 2019
4 Reads

The role of galectin-3 in heart failure and cardiovascular disease.

Clin Exp Pharmacol Physiol 2018 Oct 29. Epub 2018 Oct 29.

Cardiovascular Center, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.

Galectin-3, a β-galactoside-binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in patients with cardiovascular disease. Genetic or pharmacological inhibition of galectin-3 slows down the progression of myocardial inflammation, reduces collagen production, attenuates cardiac remodelling, and ameliorates cardiac function. In this review, we summarize recent progress in research on galectin-3 as a regulatory molecule involved in cardiovascular fibrosis in HF and its potential role in the diagnosis, risk assessment and treatment of cardiovascular diseases. Read More

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http://doi.wiley.com/10.1111/1440-1681.13048
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http://dx.doi.org/10.1111/1440-1681.13048DOI Listing
October 2018
13 Reads

miR-375-3p/YWHAZ/β-catenin axis regulates migration, invasion, EMT in gastric cancer cells.

Clin Exp Pharmacol Physiol 2019 Feb 21;46(2):144-152. Epub 2018 Dec 21.

Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, China.

YWHAZ (14-3-3ζ) plays crucial roles in regulating proliferation, apoptosis, migration, and invasion of gastric cancer (GC) cells. However, its extensive roles and potential mechanisms in GC cells remain unknown, and need to be researched deeply. In this study, we focus on the role of miR-375/YWHAZ axis in migration, invasion and epithelial-to-mesenchymal transition (EMT) of GC cells. Read More

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http://doi.wiley.com/10.1111/1440-1681.13047
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http://dx.doi.org/10.1111/1440-1681.13047DOI Listing
February 2019
7 Reads

NF-κB activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock.

Clin Exp Pharmacol Physiol 2019 Feb;46(2):173-182

Department of Pharmacology, Faculty of Pharmacy, Izmir Katip Celebi University, Izmir, Turkey.

We have previously demonstrated that the activation of the spleen tyrosine kinase (Syk)/inhibitory-κB (IκB)-α/nuclear factor-κB (NF-κB) p65 signalling pathway contributes to hypotension and inflammatory response in a rat models of zymosan (ZYM)-induced non-septic shock. The purpose of this study was to further examine the possible mechanism underlying the effect of inhibition of Syk by BAY61-3606 via NF-κB activity at the level of nuclear translocation regarding the production of vasodilator and proinflammatory mediators in lipopolysaccharide (LPS) (septic)- and ZYM (non-septic)-induced shock. Administration of LPS (10 mg/kg, ip) or ZYM (500 mg/kg, ip) to male Wistar rats decreased mean arterial pressure and increased heart rate that was associated with an increase in the activities of cyclooxygenase and nitric oxide synthase, tumour necrosis factor-α, and interleukin-8 levels, and NF-κB activation and nuclear translocation in sera and/or cardiovascular and renal tissues. Read More

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http://doi.wiley.com/10.1111/1440-1681.13045
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http://dx.doi.org/10.1111/1440-1681.13045DOI Listing
February 2019
8 Reads

Supporting preterm cardiovascular function.

Clin Exp Pharmacol Physiol 2018 Oct 22. Epub 2018 Oct 22.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia.

Preterm infants are at higher risk of adverse neurodevelopmental outcomes. Inadequate cerebral oxygen delivery resulting from poor cardiovascular function is likely to be a significant contributor to preterm brain injury. In this context, improved support of cardiovascular function is integral to improving preterm outcomes. Read More

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http://doi.wiley.com/10.1111/1440-1681.13044
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http://dx.doi.org/10.1111/1440-1681.13044DOI Listing
October 2018
9 Reads

Multicenter analysis of the efficacy and safety of a non-standard immunosuppressive therapy with rituximab in children with steroid-resistant nephrotic syndrome.

Clin Exp Pharmacol Physiol 2018 Oct 22. Epub 2018 Oct 22.

Department of Paediatric Nephrology and Dialysis, University of Poznan, Poznan, Poland.

The aim of the study was a multicenter analysis of the efficacy and safety of a non-standard immunosuppressive therapy with rituximab (Rtx) in children with steroid-resistant nephrotic syndrome (SRNS) with particular emphasis on the possibility of permanent discontinuation or dose reduction of other immunosuppressive drugs such as glucocorticoids and cyclosporine A after 6 months of observation. The study group consisted of 30 children with idiopathic nephrotic syndrome, who were unresponsive to standard immunosuppressive treatment, and hospitalized in the years 2010-2017 in eight paediatric nephrology centres in Poland. The children were administered a single initial infusion of rituximab at the dose of 375 mg/m of the body surface area. Read More

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http://doi.wiley.com/10.1111/1440-1681.13046
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http://dx.doi.org/10.1111/1440-1681.13046DOI Listing
October 2018
14 Reads

Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension.

Clin Exp Pharmacol Physiol 2018 Oct 19. Epub 2018 Oct 19.

Department of Surgery and Physiology, UnIC-Cardiovascular Research Centre, Faculty of Medicine, University of Porto, Porto, Portugal.

We have previously shown that treatment with recombinant human neuregulin-1 (rhNRG-1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)-induced animal model, by decreasing pulmonary arterial remodelling and endothelial dysfunction, as well as by restoring right ventricular (RV) function. Additionally, rhNRG-1 treatment showed direct myocardial anti-remodelling effects in a model of pressure loading of the RV without PAH. This work aimed to study the intrinsic cardiac effects of rhNRG-1 on experimental PAH and RV pressure overload, and more specifically on diastolic stiffness, at both the ventricular and cardiomyocyte level. Read More

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http://doi.wiley.com/10.1111/1440-1681.13043
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http://dx.doi.org/10.1111/1440-1681.13043DOI Listing
October 2018
10 Reads

The PXXP domain is critical for the protective effect of BAG3 in cardiomyocytes.

Clin Exp Pharmacol Physiol 2018 Oct 16. Epub 2018 Oct 16.

Department of Pharmacology, Nantong University School of Pharmacy, Nantong, China.

Bcl-2-associated athanogene3(BAG3) protects the heart and cardiomyocytes from ischaemia/reperfusion (I/R) injury. Although theanti-apoptosis effect of BAG3 has been demonstratedin multiple cell types, the structural domain of BAG3,which is responsible for its anti-apoptosis effect, is not well understood. BAG3 protein consists of various characteristic amino acid motifs/regions that permit the interaction of BAG3 with numerous proteins involved in many cellular key pathways. Read More

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http://doi.wiley.com/10.1111/1440-1681.13031
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http://dx.doi.org/10.1111/1440-1681.13031DOI Listing
October 2018
13 Reads

MiR-182 enhances radioresistance in non-small cell lung cancer cells by regulating FOXO3.

Clin Exp Pharmacol Physiol 2019 Feb;46(2):137-143

Department of Respiratory Medicine, People's Hospital of Haining, Haining, China.

Upregulated in lung cancer, miRNA-182 was found to be related to cancer proliferation and chemoresistance. However, there is no report on the role of miR-182 in radioresistance, which is a main obstacle of radiotherapy. In this study, we aim to depict the effect of miR-182 inhibition on cellular sensitivity to ionizing radiation. Read More

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http://doi.wiley.com/10.1111/1440-1681.13041
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http://dx.doi.org/10.1111/1440-1681.13041DOI Listing
February 2019
3 Reads

MiR-101a ameliorates AngII-mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF-κB signalling in a mouse model of hypertension.

Clin Exp Pharmacol Physiol 2018 Oct 10. Epub 2018 Oct 10.

Wuxi No. 2 People's Hospital, Affiliated Hospital of Nanjing Medical University, Wuxi, China.

Hypertensive nephropathy, clinically characterized by progressive renal fibrosis and inflammation, is a severe complication of hypertension. The objectives of this study were to investigate the roles of miR-101a in relieving angiotensin II (Ang II)-mediated hypertensive nephropathy and uncover the possible underlying mechanisms. A hypertensive mouse model was established via continuous 28-day AngII infusion. Read More

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http://dx.doi.org/10.1111/1440-1681.13042DOI Listing
October 2018
3 Reads

Maternal L-carnitine supplementation ameliorates renal underdevelopment and epigenetic changes in male mice offspring due to maternal smoking.

Clin Exp Pharmacol Physiol 2019 Feb 22;46(2):183-193. Epub 2018 Nov 22.

Renal Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Objectives: Epidemiological and animal studies showed that L-carnitine (LC) supplementation can ameliorate oxidative stress-induced tissues damage. We have previously shown that maternal cigarette smoke exposure (SE) can increase renal oxidative stress in newborn offspring with postnatal kidney underdevelopment and renal dysfunction in adulthood, which were normalised by LC administration in the SE dams during pregnancy. Exposure to an adverse intrauterine environment may lead to alteration in the epigenome, a mechanism by which adverse prenatal conditions increase the susceptibility to chronic disease later in life. Read More

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http://doi.wiley.com/10.1111/1440-1681.13038
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http://dx.doi.org/10.1111/1440-1681.13038DOI Listing
February 2019
5 Reads

Unfolding the pleiotropic facades of rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders.

Clin Exp Pharmacol Physiol 2018 Oct 5. Epub 2018 Oct 5.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), New Delhi, India.

Rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme (HMG-CoA) reductase inhibitor, and one of the most popular antihyperlipidemic medications have been found to possess pharmacodynamic activities much different from its usual indication. Recent research studies have revealed the efficacy of rosuvastatin in attenuating neuroinflammation, reducing the progression of Alzheimer's disease, providing protection against cerebral ischaemia and spinal cord injury as well as ameliorating epilepsy. Mechanisms behind the neuroprotective potential of rosuvastatin can be attributed to its pleiotropic effects, independent of its ability to inhibit HMG-CoA reductase. Read More

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http://doi.wiley.com/10.1111/1440-1681.13040
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http://dx.doi.org/10.1111/1440-1681.13040DOI Listing
October 2018
2 Reads

N-Acetylcysteine potentiates the haemodynamic-improving effect of sildenafil in a rabbit model of acute pulmonary thromboembolism via the p38 MAPK pathway.

Clin Exp Pharmacol Physiol 2019 Feb 14;46(2):163-172. Epub 2018 Nov 14.

Department of Peripheral Angiopathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

The current study aimed to investigate the effects of sildenafil and N-acetylcysteine (NAC) on the haemodynamics in a rabbit model of acute pulmonary thromboembolism (APT). We developed an APT model using healthy male China big-ear rabbits (2.7 ± 0. Read More

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http://dx.doi.org/10.1111/1440-1681.13039DOI Listing
February 2019
1 Read

(-)-Epigallocatechin-3-gallate induces cell apoptosis in chronic myeloid leukaemia by regulating Bcr/Abl-mediated p38-MAPK/JNK and JAK2/STAT3/AKT signalling pathways.

Clin Exp Pharmacol Physiol 2019 Feb 30;46(2):126-136. Epub 2018 Oct 30.

Department of Haematology, The Second Xiangya Hospital, Central South University, Changsha, China.

Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, possesses remarkable chemopreventive and therapeutic potential against various types of cancer, including leukaemia. However, the molecular mechanism involved in chronic myeloid leukaemia (CML), especially imatinib-resistant CML cells, is not completely understood. In the present study, we investigated the effect of EGCG on the growth of Bcr/Abl+ CML cell lines, including imatinib-resistant cell lines and primary CML cells. Read More

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http://dx.doi.org/10.1111/1440-1681.13037DOI Listing
February 2019
6 Reads

Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity.

Clin Exp Pharmacol Physiol 2018 Sep 23. Epub 2018 Sep 23.

Department of Surgery and Physiology, UnIC-Cardiovascular Research Centre, Faculty of Medicine, University of Porto, Porto, Portugal.

Anthracycline chemotherapy has a prominent role in treating many forms of cancer. Unfortunately, cardiotoxic side effects represent a serious limitation to their use, with doxorubicin being the leading drug of the group. Indeed, anthracycline-induced cardiomyopathy is an important public health concern because it may not be detected for many years and remains a lifelong threat. Read More

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http://dx.doi.org/10.1111/1440-1681.13036DOI Listing
September 2018
4 Reads

Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage.

Clin Exp Pharmacol Physiol 2019 Jan;46(1):99-102

Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r = 0.52, P < 0. Read More

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http://dx.doi.org/10.1111/1440-1681.13035DOI Listing
January 2019
2 Reads

Omega-3 fatty acids in coronary heart disease: Recent updates and future perspectives.

Clin Exp Pharmacol Physiol 2019 Jan 16;46(1):11-18. Epub 2018 Oct 16.

Department of Interventional Cardiology, Amala Cardiac Centre, Thrissur, Kerala, India.

Incidence of coronary heart disease (CHD) increases worldwide with varying etiological factors. In addition to the control of risk factors, dietary modification has been recommended to reduce the prevalence. Omega-3 (ω-3) fatty acids (FAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), of fish oil are beneficial for the prevention of CHD. Read More

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http://dx.doi.org/10.1111/1440-1681.13034DOI Listing
January 2019
1 Read

Dual excitatory and smooth muscle-relaxant effect of β-phenylethylamine on gastric fundus strips in rats.

Clin Exp Pharmacol Physiol 2019 Jan 16;46(1):40-47. Epub 2018 Oct 16.

Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

β-Phenylethylamine (β-PEA) is a trace amine with chemical proximity to biogenic amines and amphetamines. It is an endogenous agonist of trace amine-associated receptors (TAARs) that acts as a neuromodulator of classic neurotransmitters in the central nervous system. At high concentrations, β-PEA contracts smooth muscle, and a role for TAARs in these responses has been postulated. Read More

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http://dx.doi.org/10.1111/1440-1681.13033DOI Listing
January 2019
3 Reads

Peripheral apelin mediates stress-induced alterations in gastrointestinal motor functions depending on the nutritional status.

Clin Exp Pharmacol Physiol 2019 Jan 16;46(1):29-39. Epub 2018 Oct 16.

Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Exposure to stress induces gastrointestinal (GI) dysmotility. In rodents, acute restraint stress (ARS) inhibits gastric emptying (GE) and intestinal transit (IT) via central and peripheral corticotropin-releasing factor (CRF)-mediated pathways. Peripherally administered apelin-13 was shown to inhibit GI motor functions; moreover, stress-induced upregulation of gastric apelin content was demonstrated in rats suggesting that peripheral apelin may mediate stress-induced alterations in GI motility. Read More

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http://dx.doi.org/10.1111/1440-1681.13032DOI Listing
January 2019
1 Read

EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy.

Clin Exp Pharmacol Physiol 2019 Jan 16;46(1):75-85. Epub 2018 Sep 16.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.

Diabetic retinopathy (DR) is one of the most frequently occurring microvascular complications of diabetes. Recent evidence indicates that epidermal growth factor receptors (EGFRs) are critical pathogenic players in non-neoplastic diseases, including diabetic cardiomyopathy and DR. However, the precise pathogenic mechanism of EGFR in DR has yet to be fully understood. Read More

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http://dx.doi.org/10.1111/1440-1681.13029DOI Listing
January 2019
5 Reads

Inflammatory cytokines tumour necrosis factor-α and interleukin-8 enhance airway smooth muscle contraction by increasing L-type Ca channel expression.

Clin Exp Pharmacol Physiol 2019 Jan 15;46(1):56-64. Epub 2018 Oct 15.

School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.

Inflammation elevates intracellular calcium concentrations ([Ca ] ) in airway smooth muscle (ASM). The L-type Ca channel (L-VDCC) plays an important role in regulating Ca influx in ASM. However, the role of L-VDCC in the inflammatory cytokine-induced pathology of ASM remains unclear. Read More

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http://dx.doi.org/10.1111/1440-1681.13030DOI Listing
January 2019
8 Reads

The roles of PD-1/PD-L1 and its signalling pathway in gastrointestinal tract cancers.

Clin Exp Pharmacol Physiol 2019 Jan 8;46(1):3-10. Epub 2018 Oct 8.

2nd Hospital of Jilin University, Changchun City, China.

Cancer immunotherapy has been increasingly applied in the treatment of advanced malignancies. Consequently, immune checkpoints have become a major concern. As PD-1 is an important immunomodulatory protein, the blockade of PD-1 and its ligand PD-L1 is a promising tumour immunotherapy for human carcinoma. Read More

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http://dx.doi.org/10.1111/1440-1681.13028DOI Listing
January 2019
18 Reads

Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax.

Clin Exp Pharmacol Physiol 2018 Aug 28. Epub 2018 Aug 28.

Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro-survival and anti-apoptotic roles through molecule phosphorylated extracellular signal-regulated kinase1/2 (p-ERK1/2) in cardiomyocytes. However, it is still unclear if silencing of C3G may increase cell survival inhibition and apoptosis in cardiomyocytes, and whether C3G silence induced injuries are reduced by the overexpression of C3G through regulation of p-ERK1/2 and pro-apoptotic molecule Bax. In this study, the rat-derived H9C2 cardiomyocytes were infected with C3G small hairpin RNA interference recombinant lentiviruses, which silenced the endogenous C3G expression in the cardiomyocytes. Read More

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http://dx.doi.org/10.1111/1440-1681.13027DOI Listing
August 2018
2 Reads

Challenges of heterotopic ossification-Molecular background and current treatment strategies.

Clin Exp Pharmacol Physiol 2018 Dec 4;45(12):1229-1235. Epub 2018 Oct 4.

Department of Orthopaedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.

Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought to be induced by inflammation associated with tissue injuries. HO is classified using two subtypes: resulting from injury or genetically inherited. Read More

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http://doi.wiley.com/10.1111/1440-1681.13025
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http://dx.doi.org/10.1111/1440-1681.13025DOI Listing
December 2018
26 Reads

Pectic polysaccharides extracted from Rauvolfia verticillata (Lour.) Baill. var. hainanensis Tsiang ameliorate ulcerative colitis via regulating the MAPKs and NF-κB pathways in dendritic cells.

Clin Exp Pharmacol Physiol 2019 Jan 1;46(1):48-55. Epub 2018 Oct 1.

Department of Gastroenterology, Hainan Provincial People's Hospital, Haikou City, Hainan Province, China.

This study was to investigate the effects and mechanisms of pectic polysaccharides (PP) extracted from Rauvolfia verticillata (Lour.) Baill. var. Read More

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http://doi.wiley.com/10.1111/1440-1681.13026
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http://dx.doi.org/10.1111/1440-1681.13026DOI Listing
January 2019
21 Reads

Dexamethasone exacerbates cisplatin-induced muscle atrophy.

Clin Exp Pharmacol Physiol 2019 Jan 23;46(1):19-28. Epub 2018 Sep 23.

Department of Biomolecular Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, Tokyo, Japan.

Dexamethasone for antiemetic therapy is typically administered with anticancer drugs such as cisplatin. We previously reported that cisplatin upregulates the muscle-specific E3 ubiquitin ligase genes, namely muscle ring-finger protein 1 (MuRF1) and atrophy gene-1 (atrogin-1), and promotes muscle atrophy in mice. It is well known that dexamethasone causes upregulation of MuRF1 and Atrogin-1 expression in skeletal muscles. Read More

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http://dx.doi.org/10.1111/1440-1681.13024DOI Listing
January 2019
15 Reads