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    3038 results match your criteria Clinical and Experimental Ophthalmology[Journal]

    1 OF 61

    The TIGER is extinct! (almost).
    Clin Exp Ophthalmol 2017 Sep 20. Epub 2017 Sep 20.
    Disha Eye Hospitals Pvt. Ltd, Kolkata, India.
    Congratulations to Dr. Rao et al(1) for highlighting a sight threatening complication of the wonder drug Rociletinib. However, an important point regarding Rociletinib needs to be highlighted which was partially brought out in an earlier article by Liu et al. Read More

    Use of a high-resolution camera (GoPro) for the slit lamp.
    Clin Exp Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Birmingham Institute for Glaucoma Research, Institute for Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
    The slit lamp enables a well-illuminated and magnified view of the eye. There have been previous imaging devices used for recording, however the quality of the stills and video is limited by cost. We present a relatively lower cost solution for the Haag-Streit slit lamp (Haag Streit AG, Switzerland) using a high definition camera, Hero5 Black (GoPro Inc. Read More

    Pseudoexfoliation syndrome and pseudoexfoliation glaucoma in New Zealand Māori.
    Clin Exp Ophthalmol 2017 Sep 12. Epub 2017 Sep 12.
    Hauora Tairawhiti, New Zealand.
    Glaucoma is a group of eye diseases which results in a progressive and characteristic optic neuropathy and visual loss. It is well known that the prevalence of glaucoma fluctuates in various societies and ethnicities around the world. Pseudoexfoliation glaucoma (PXG) is a common form of secondary glaucoma worldwide. Read More

    Design and methodology of the Shanghai child and adolescent large-scale eye study (SCALE).
    Clin Exp Ophthalmol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
    Importance: Nearly half of children suffering vision impairment reside in China with myopia accounting for the vast majority.

    Background: To describe the design and methodology of the Shanghai Child and Adolescent Large-scale Eye Study (SCALE).

    Design: The SCALE was a city wide, school-based, prospective survey. Read More

    Structural and functional imaging of aqueous humor outflow: a review.
    Clin Exp Ophthalmol 2017 Sep 12. Epub 2017 Sep 12.
    Shiley Eye Institute and Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, USA.
    Maintaining healthy aqueous humor outflow (AHO) is important for intraocular cellular health and stable vision. Impairment of AHO can lead to increased intraocular pressure, optic nerve damage, and concomitant glaucoma. An improved understanding of AHO will lead to improved glaucoma surgeries that enhance native AHO as well as facilitate the development of AHO-targeted pharmaceuticals. Read More

    Age-related changes in and determinants of macular ganglion cell-inner plexiform layer thickness in normal Chinese adults.
    Clin Exp Ophthalmol 2017 Sep 12. Epub 2017 Sep 12.
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing ophthalmology & Visual Science Key Lab, Beijing, China.
    Importance: Consideration of age-related changes in macular ganglion cell-inner plexiform layer (mGCIPL) thickness are important for glaucoma progression analysis.

    Background: To report age-related changes in and the determinants of high-definition optical coherence tomography (HD-OCT) measurements of mGCIPL thickness.

    Design: Cross-sectional study. Read More

    Meta-analysis of accuracy of intraocular lens power calculation formulas in short eyes.
    Clin Exp Ophthalmol 2017 Sep 9. Epub 2017 Sep 9.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
    Importance: Intraocular lens (IOL) power selection is a critical factor affecting visual outcome after IOL implantation in short eyes. Many formulas have been developed to achieve a precise prediction of the IOL power. However, controversy regarding the accuracy remains. Read More

    Diabetic retinopathy screening using deep neural network.
    Clin Exp Ophthalmol 2017 Sep 7. Epub 2017 Sep 7.
    Dunedin Hospital, Dunedin, New Zealand.
    Importance There is a burgeoning interest in the use of deep neural network in diabetic retinal screening.

    Background: To determine whether a deep neural network could satisfactorily detect diabetic retinopathy that requires referral to an ophthalmologist from a local diabetic retinal screening programme and an international database. Design Retrospective audit Samples Diabetic retinal photos from Otago database photographed during October 2016 (485 photos); and 1200 photos from Messidor international database. Read More

    Are cataract surgery referrals to public hospitals in Australia poorly targeted?
    Clin Exp Ophthalmol 2017 Sep 7. Epub 2017 Sep 7.
    The George Institute for Global Health, University of New South Wales, NSW, Australia.
    Importance Referral letters constitute the first step on the pathway to cataract surgery, however little is known on how effective referral letters are in providing adequate information to triage patients and inform surgical prioritisation.

    Background: Benchmarking exercises are important to document referral processes and to identify areas where improvements can be made. Design Cross-sectional study with longitudinal follow-up conducted at two metropolitan public hospitals in New South Wales, Australia. Read More

    Why aren't we prescribing more valaciclovir for Herpes infections of the eye? Is it time for a change of practice in New Zealand?
    Clin Exp Ophthalmol 2017 Sep 1. Epub 2017 Sep 1.
    Nelson Hospital, New Zealand.
    Based on the Herpetic Eye Disease Study,(1) aciclovir has been used in the prevention of recurrent Herpes Simplex Virus (HSV) keratitis for nearly 20 years.(2) At that time aciclovir (Zovirax) and topical trifluridine (Viroptic) were the medications available for use. Based on clinical evidence, oral aciclovir is also used in the treatment of Herpes Zoster Ophthalmicus. Read More

    Association of intraocular pressure related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma.
    Clin Exp Ophthalmol 2017 Aug 31. Epub 2017 Aug 31.
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
    Importance: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA).

    Design: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over.

    Methods: All participants underwent a comprehensive eye examination, fundus photograph based measurements of RVD and Heidelberg retinal tomogram (HRT) measurement of optic disc. Read More

    Pre-operative risk stratification of 646 cataract cases at Waikato Hospital, New Zealand.
    Clin Exp Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Waikato Hospital, Hamilton, New Zealand.
    This article reports the results of a single-centre study which has applied prospective risk analysis to predict posterior capsule rupture or vitreous loss (PCR/VL) during cataract surgery at a tertiary teaching centre in New Zealand; this risk analysis was used to select cases for trainees based on risk of complications. Data was collected at Waikato Public Hospital from July 2014 to May 2017. A total of 646 cases were recorded for 9 surgeons: 1 consultant, 5 senior registrars and 3 junior registrars. Read More

    Clinical and social characteristics associated with reduced visual acuity at presentation in Australian patients with neovascular age-related macular degeneration: a prospective study from a long term observational dataset. The Fight Retinal Blindness Project.
    Clin Exp Ophthalmol 2017 Aug 25. Epub 2017 Aug 25.
    The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
    Importance: Identifying variables that influence presenting visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) is important because it is a strong predictor of long-term outcomes.

    Background: To assess the clinical and social characteristics associated with low presenting VA in nAMD patients.

    Design: Cross-sectional analysis from a prospective, observational database. Read More

    Minimal Iris Touch Excision (MITE): a novel surgical technique for local excision of iris melanoma.
    Clin Exp Ophthalmol 2017 Aug 25. Epub 2017 Aug 25.
    Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, New Zealand.
    Surgical treatments of iris melanoma are aimed at complete resection with minimal manipulation or tumor disruption.(1) Sector iridectomy is a standard surgical intervention for circumscribed iris tumors without seeding or involvement of the iris root. We describe a novel, minimal-touch, variation of sector iridectomy for the excision of circumscribed iris lesions performed in three patients with iris tumors suspicious for melanoma. Read More

    Risk factors of age-related cataract in a Chinese adult population: the Taizhou Eye Study.
    Clin Exp Ophthalmol 2017 Aug 25. Epub 2017 Aug 25.
    Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Xuhui District, Shanghai, China.
    Importance: Cataract risk factors data will provide epidemic evidence for cataract prevention.

    Background: To study the risk factors for age-related cataract (ARC) in a Chinese adult population.

    Design: Population-based, cross-sectional study. Read More

    Utilization of eye health-care services in Australia: the National Eye Health Survey.
    Clin Exp Ophthalmol 2017 Aug 9. Epub 2017 Aug 9.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
    Importance: National data on eye health-care service utilization will inform Australia's eye health policy.

    Background: To investigate the utilization of eye health-care services by Australians.

    Design: Cross-sectional survey. Read More

    Comparison of Hill-radial basis function, Barrett Universal and current third generation formulas for the calculation of intraocular lens power during cataract surgery.
    Clin Exp Ophthalmol 2017 Aug 4. Epub 2017 Aug 4.
    Vision Eye Institute, Sydney, New South Wales, Australia.
    Importance: This study represents a novel comparison of recently introduced intraocular lens power calculation formulas.

    Background: To compare current new generation formulas for calculating the intraocular lens power for a standard cohort of patients undergoing cataract and lens replacement surgery in a private group practice in Australia.

    Design: Retrospective case series comparison. Read More

    Prevalence of retinal vein occlusion in the Australian National Eye Health Survey.
    Clin Exp Ophthalmol 2017 Jul 28. Epub 2017 Jul 28.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
    Importance: In Australia, knowledge of the epidemiology of retinal vein occlusion remains scarce because of a paucity of recent population-based data. The National Eye Health Survey (2015-2016) provides an up-to-date estimate of the prevalence of retinal vein occlusion in non-Indigenous and Indigenous Australian adults.

    Background: To determine the prevalence and associations of retinal vein occlusion in a national sample of Indigenous and non-Indigenous Australian adults. Read More

    Long term outcomes after acute primary angle closure of Caucasian chronic angle closure glaucoma (CACG) patients.
    Clin Exp Ophthalmol 2017 Jul 19. Epub 2017 Jul 19.
    Singapore National Eye Center, Singapore.
    Importance: There is a lack of information about long term results of chronic angle closure glaucoma (CACG) following an acute primary angle closure (APAC) in Caucasian patients PURPOSE: To report morphological and functional long-term data of CACG eyes following a monolateral APAC attack and to provide a comparison with their fellow eyes DESIGN: Observational retrospective case series (Clinica Oculistica Universitaria, Ospedale Oftalmico, Turin) PARTICIPANTS: 57 consecutive patients (114 eyes) underwent long term follow-up analysis.

    Methods: Patients underwent ophthalmic assessment more than 5 years since the APAC attack.

    Main Outcome Measures: Intraocular pressure (IOP), number of antiglaucoma medications, best corrected visual acuity (BCVA), angle assessment with gonioscopy, Vertical Cup-To-Disc ratio (VCDR), Standard automated perimetry (SAP). Read More

    Paradigm shifts, peregrinations and pixies in ophthalmology.
    Clin Exp Ophthalmol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Ophthalmology, University of New South Wales at Prince of Wales Hospital, Sydney, Australia.
    Human ingenuity is challenged by defending vision, our highest bandwidth sense. Special challenges are presented by the replacement or repair of highly specialized but scarce tissue within the constraints of transparency, tissue shape and alignment, tissue borders and pressure maintenance. Many, mostly destructive, surgical procedures were developed prior to an understanding of underlying pathophysiology. Read More

    Novel mobility test to assess functional vision in patients with inherited retinal dystrophies.
    Clin Exp Ophthalmol 2017 Jul 11. Epub 2017 Jul 11.
    Spark Therapeutics, Inc., Philadelphia, Pennsylvania, USA.
    Importance: This novel endpoint tracks functional vision changes in patients with inherited retinal dystrophies (IRDs) over time.

    Background: The aims of the study were to determine whether a multi-luminance mobility test (MLMT) can detect functional vision changes over time in subjects with IRDs and to assess natural history and potential effects of investigational agents.

    Design: This is a prospective, observational study. Read More

    Glaucoma Australia educational impact study: a randomized short-term clinical trial evaluating the association between glaucoma education and patient knowledge, anxiety and treatment satisfaction.
    Clin Exp Ophthalmol 2017 Jul 9. Epub 2017 Jul 9.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia.
    Importance: Targeted education may impact glaucoma patients' clinical experience.

    Background: The aim of this study was to measure the impact of patient-centred glaucoma-related education on knowledge, anxiety and treatment satisfaction.

    Design: This was a multicentre Australia-wide randomized clinical trial. Read More

    Evaluating the impact of optical coherence tomography in diabetic retinopathy screening for an Aboriginal population.
    Clin Exp Ophthalmol 2017 Jul 4. Epub 2017 Jul 4.
    Lions Outback Vision, Perth, Western Australia, Australia.
    Importance: Optical coherence tomography is used routinely in management of diabetic eye disease but has not been evaluated in Australian outreach settings for screening programmes.

    Background: The study aims to evaluate the use of optical coherence tomography combined with a fundus camera compared with a fundus camera only in a telehealth diabetic retinopathy screening programme for Aboriginal Australians.

    Design: Retrospective comparative study was used. Read More

    'Blue bubble' technique: an ab interno approach for Descemet separation in deep anterior lamellar keratoplasty using trypan blue stained viscoelastic device.
    Clin Exp Ophthalmol 2017 Jul 3. Epub 2017 Jul 3.
    Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.
    Background: In this study, we examined a novel variant of 'big-bubble' deep anterior lamellar keratoplasty using trypan-blue-stained viscoelastic device for the creation of a pre-descemetic bubble.

    Methods: Ten corneoscleral rims were mounted on an artificial anterior chamber (AC). The AC was filled with air through a limbal paracentesis. Read More

    Social, health and ocular factors associated with primary open-angle glaucoma amongst Chinese Singaporeans.
    Clin Exp Ophthalmol 2017 Jun 16. Epub 2017 Jun 16.
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
    Importance: There is limited literature on lifestyle and health factors related to primary open-angle glaucoma amongst Asians.

    Background: This study evaluated the association of primary open-angle glaucoma with smoking, health and ocular factors amongst Chinese Singaporeans.

    Design: Case-control study. Read More

    Association of disease-specific causes of visual impairment and 10-year mortality amongst Indigenous Australians: the Central Australian Ocular Health Study.
    Clin Exp Ophthalmol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia.
    Importance: Visual impairment significantly impairs the length and quality of life, but little is known of its impact in Indigenous Australians.

    Background: To investigate the association of disease-specific causes of visual impairment with all-cause mortality.

    Design: A retrospective cohort analysis. Read More

    Aqueous vascular endothelial growth factor and aflibercept concentrations after bimonthly intravitreal injections of aflibercept for age-related macular degeneration.
    Clin Exp Ophthalmol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan.
    Importance: Clinical evidence supports the efficacy of bimonthly aflibercept injection for age-related macular degeneration.

    Background: The study aimed to evaluate aqueous vascular endothelial growth factor and aflibercept concentrations and the efficacy of bimonthly aflibercept in patients with age-related macular degeneration.

    Design: This study is a prospective, interventional case series. Read More

    Steady-state pattern electroretinogram and short-duration transient visual evoked potentials in glaucomatous and healthy eyes.
    Clin Exp Ophthalmol 2017 Jun 10. Epub 2017 Jun 10.
    Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA.
    Importance: This study evaluates two rapid electrophysiological glaucoma diagnostic tests that may add a functional perspective to glaucoma diagnosis.

    Background: This study aimed to determine the ability of two office-based electrophysiological diagnostic tests, steady-state pattern electroretinogram and short-duration transient visual evoked potentials, to discern between glaucomatous and healthy eyes.

    Design: This is a cross-sectional study in a hospital setting. Read More

    Prevalence of trachomatous trichiasis in Australia: the National Eye Health Survey.
    Clin Exp Ophthalmol 2017 Jun 9. Epub 2017 Jun 9.
    Indigenous Eye Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
    Importance: Australia is the only developed country to still have pockets of endemic trachoma. The research provides up-to-date, population-based prevalence data of later complications of trachoma amongst a national sample of Indigenous adults.

    Background: To report the prevalence of trachomatous trichiasis (TT) in Indigenous Australians aged 40 years and older. Read More

    Can we improve the efficacy of modern cataract surgery by using different tip designs? A comparison of balanced and tapered tip in femtosecond laser-assisted cataract surgery and manual phacoemulsification.
    Clin Exp Ophthalmol 2017 May 31. Epub 2017 May 31.
    Eye Clinic Wittenbergplatz, Berlin, Germany.
    Importance: Different tip designs in modern cataract surgery have not been studied between the reported systems.

    Background: Aim of this study is to assess the efficacy of two tip designs, Intrepid® balanced tip (BT) and Kelman tapered tip (TT), in femtosecond laser assisted cataract surgery (FLACS) and the microcoaxial torsional phacoemulsification.

    Design: Prospective randomized unmasked cohort outcome study (hospital setting). Read More

    Diabetic macular oedema: evidence-based treatment recommendations for Asian countries.
    Clin Exp Ophthalmol 2017 May 30. Epub 2017 May 30.
    Singapore National Eye Centre, Singapore.
    Diabetic macular oedema is the most common cause of diabetic retinopathy-induced vision loss. Efficacy of anti-vascular endothelial growth factor therapy in diabetic macular oedema has been demonstrated in randomized controlled trials. An Asian-specific guideline for diabetic macular oedema treatment is needed as patients in Asia tend to present with far more advanced disease than seen elsewhere in the world. Read More

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