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    3198 results match your criteria Clinical and Experimental Ophthalmology[Journal]

    1 OF 64

    Neuroprotection in glaucoma: recent advances and clinical translation.
    Clin Exp Ophthalmol 2018 Jun 13. Epub 2018 Jun 13.
    South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia.
    Intraocular pressure (IOP) reduction is currently the only evidence-based treatment strategy for glaucoma. However, IOP control in some individuals is challenging. Despite optimal treatment, a significant proportion of individuals will progress, with loss of visual field, loss of driving vision, and impaired quality of life. Read More

    Topical axitinib is a potent inhibitor of corneal neovascularization.
    Clin Exp Ophthalmol 2018 Jun 11. Epub 2018 Jun 11.
    Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain.
    Background: To evaluate the effects of topically applied axitinib, a tyrosine kinase inhibitor, in an experimental model of corneal neovascularization (CNV).

    Methods: Forty-eight New Zealand rabbits were used. CNV was induced by placing 5 silk sutures in the upper cornea of one eye per rabbit. Read More

    Canaloplasty case series for primary open-angle glaucoma in rural Australia.
    Clin Exp Ophthalmol 2018 Jun 1. Epub 2018 Jun 1.
    Tamara Private Hospital, Tamworth, NSW, Australia.
    Canaloplasty (CP) is a blebless non-penetrating Glaucoma surgery (NPGS) performed to lower intraocular pressure in patients. A 10-0 suture is positioned using a microcatheter guide and then left under tension in Schlemm's canal to facilitate drainage through normal pathways. Although trabeculectomy remains the most common procedure for treating glaucoma, CP delivers an almost equivalent reduction in IOP with fewer complications and less demanding post-operative care. Read More

    Long-term outcomes of hemi-automated lamellar keratoplasty.
    Clin Exp Ophthalmol 2018 Jun 1. Epub 2018 Jun 1.
    Singapore Eye Research Institute, Singapore.
    Importance: To describe long-term outcomes of hemi-automated lamellar keratoplasty (HALK).

    Background: HALK is a hybrid anterior lamellar keratoplasty technique for corneas with anterior to mid-stromal scars and topographical irregularities.

    Design: Prospective interventional case series. Read More

    Safety and effectiveness of primary transscleral diode laser cyclophotoablation for glaucoma in Nigeria.
    Clin Exp Ophthalmol 2018 May 28. Epub 2018 May 28.
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
    Importance: To investigate the safety, effectiveness and follow-up rates after transscleral diode laser cyclophotocoagulation as primary treatment for seeing eyes with primary open angle glaucoma in Bauchi, Nigeria.

    Background: There is a high prevalence of primary open angle glaucoma in Africa where adherence to medical treatment and acceptance of surgery are poor.

    Design: Prospective case series. Read More

    Prevalence of reduced visual acuity among preschool children in eastern China and comparison at a five-year interval.
    Clin Exp Ophthalmol 2018 May 26. Epub 2018 May 26.
    Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
    Importance: Assessing the prevalence of reduced visual acuity and its change over time has significant public health importance. This study evaluated prevalence of reduce visual acuity in children aged 48 to 60 months, and compared it with previous data.

    Background: Previous studies reported prevalence of reduced visual acuity in preschool children, but none has evaluated prevalence change in the same area. Read More

    Ocular surface status in glaucoma and ocular hypertension patients with existing corneal disorders switched from latanoprost 0.005% to tafluprost 0.0015%: comparison of two prostaglandin analogues with different concentrations of benzalkonium chloride.
    Clin Exp Ophthalmol 2018 May 26. Epub 2018 May 26.
    Singapore National Eye Centre (SNEC), Singapore.
    Importance: Glaucoma treatment has often been associated with adverse side-effects from preservatives that are included in the used eye drops.

    Background: To evaluate changes in the ocular surface and the presence of prostaglandin-induced corneal disorders after being switched from latanoprost 0.005% to low preservative tafluprost 0. Read More

    Microcystic macular oedema in optic neuropathy: case series and literature review.
    Clin Exp Ophthalmol 2018 May 25. Epub 2018 May 25.
    Save Sight Institute, University of Sydney, NSW, Australia.
    Cavitations in the inner nuclear layer associated with severe optic atrophy and loss of retinal ganglion cells have clinically been termed microcystic macular oedema (MME). We describe a case series of MME in patients of all ages but predominantly younger patients with a wide range of optic atrophies ranging from acute onset optic disc drusen associated ischemic optic neuropathy to slowly progressive disease as glaucoma. There were no physical distinctions between MME in different causes of optic atrophy suggesting a common causative mechanism. Read More

    Peripapillary vessel density changes in Leber's Hereditary Optic Neuropathy: a new biomarker.
    Clin Exp Ophthalmol 2018 May 22. Epub 2018 May 22.
    Studio Oculistico d'Azeglio, Bologna, Italy.
    Importance: The contribution of the microvascular supply to the pathogenesis of Leber's Hereditary Optic Neuropathy (LHON) is poorly understood.

    Background: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON.

    Design: Prospective, cross-sectional, multicenter, observational study. Read More

    Ocular coherence tomography-measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study.
    Clin Exp Ophthalmol 2018 May 16. Epub 2018 May 16.
    Vision and Eye Research Unit, Postgraduate Medical Institute, Anglia Ruskin University, Cambridge, UK.
    Importance: The change in the anatomical dimensions over time and the effect on diurnal intraocular pressure (DIOP) following laser peripheral iridotomy is poorly understood.

    Background: To evaluate change over time in anterior chamber angle anatomy following laser peripheral iridotomy (LPI) in patients with primary angle closure compared to control eyes. Additionally, the effect of LPI on DIOP fluctuation was investigated. Read More

    Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis.
    Clin Exp Ophthalmol 2018 May 10. Epub 2018 May 10.
    Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.
    Importance: To standardize initial anti-viral therapy for herpes simplex keratitis (HSK).

    Background: To determine prescribing trends for the management of HSK and compare the trends to available clinical trial evidence.

    Design: Retrospective review of patients at the Sydney Eye Hospital, Australia. Read More

    Alteration of layer thickness in the choroid of diabetic patients.
    Clin Exp Ophthalmol 2018 May 9. Epub 2018 May 9.
    Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
    Importance: Choroidal thickness changes in diabetic retinopathy improve the understanding of the pathophysiology and managements of this disease.

    Background: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR).

    Design: Case control study. Read More

    Comparing visual acuity, range of vision and spectacle independence in the extended range of vision and monofocal intraocular lens.
    Clin Exp Ophthalmol 2018 May 3. Epub 2018 May 3.
    School of Rural Health, Monash University, Melbourne, Victoria, Australia.
    Importance: This study is the first to compare the extended range of vision (ERV) intraocular lens (IOL) targeted at micro-monovision to a monofocal targeted at binocular emmetropia.

    Background: Compares visual acuity, range of vision and spectacle independence in monofocal and ERV IOLs.

    Design: Assessor-blinded retrospective cohort study. Read More

    Refractive regression after laser in situ keratomileusis.
    Clin Exp Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong.
    Uncorrected refractive errors are a leading cause of visual impairment across the world. In today's society, laser in situ keratomileusis (LASIK) has become the most commonly performed surgical procedure to correct refractive errors. However, regression of the initially achieved refractive correction has been a widely observed phenomenon following LASIK since its inception more than two decades ago. Read More

    Effect of a punctal plug on ocular surface disease in patients using topical prostaglandin analogues: a randomized controlled trial.
    Clin Exp Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.
    Importance: Ocular surface disease (OSD) is common and can reduce treatment compliance and quality of life.

    Background: To determine whether a punctal plug improves OSD and reduces intraocular pressure (IOP) in patients using prostaglandin analogue monotherapy.

    Design: Randomized controlled trial. Read More

    Mortality after endophthalmitis following contemporary phacoemulsification cataract surgery.
    Clin Exp Ophthalmol 2018 Apr 24. Epub 2018 Apr 24.
    Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
    Importance: To determine if endophthalmitis following cataract surgery is linked to increased mortality.

    Background: Increased mortality has been linked to patients with cataract and cataract surgery. We tested the hypothesis that post-cataract endophthalmitis has a greater risk of death than pseudophakes who do not develop this complication. Read More

    Age-related scattered hypofluorescent spots on late-phase indocyanine green angiography: the multimodal imaging and relevant factors.
    Clin Exp Ophthalmol 2018 Apr 19. Epub 2018 Apr 19.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
    Importance: Fundus aging and its imaging features.

    Background: To characterize the demographic and multimodal-imaging features of age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA).

    Design: A hospital-based retrospective study. Read More

    Emerging diagnostic tests for vitreoretinal lymphoma: a review.
    Clin Exp Ophthalmol 2018 Apr 19. Epub 2018 Apr 19.
    Eye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, South Australia, Australia.
    Vitreoretinal lymphoma, which most commonly is diffuse large B-cell non-Hodgkin in type, is a rare cancer with high morbidity and high mortality. Making a tissue diagnosis of vitreoretinal lymphoma is a major challenge for clinicians due to biological and technical factors. Yet, the delay in start of treatment may have vision- and life-threatening consequences, and there is considerable interest in the application of molecular assays to improve the accuracy of the diagnostic process: detection of a clonal immunoglobulin heavy-chain rearrangements in lymphoma cells by polymerase chain reaction; measurement of vitreous or aqueous interleukin-10 protein levels in ocular fluids; and identification of mutations in the myeloid differentiation primary response gene 88 in tumour cells. Read More

    Distribution and progression of add power among people in need of near correction.
    Clin Exp Ophthalmol 2018 Apr 16. Epub 2018 Apr 16.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
    Importance: This study helps to better understand the need and trend in presbyopic add power in the aging society.

    Background: Distribution and progression of presbyopic add power in East Asian population is largely unknown.

    Design: Prospective cohort study. Read More

    Alteration of layer thickness in the choroid of diabetic patients.
    Clin Exp Ophthalmol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
    Importance: Choroidal thickness changes in diabetic retinopathy improve understanding the pathophysiology and managements of this disease.

    Background: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR).

    Design: Case control study. Read More

    Long-term visual outcomes for treatment of submacular haemorrhage secondary to polypoidal choroidal vasculopathy.
    Clin Exp Ophthalmol 2018 Apr 13. Epub 2018 Apr 13.
    Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Importance: There is no consensus on the optimal management of submacular haemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV).

    Background: To compare the long-term outcome of three treatment strategies for PCV with SMH.

    Design: Retrospective case series at two tertiary hospitals. Read More

    Five-year refractive changes in a rural Chinese adult population and its related factors: the Handan Eye Study.
    Clin Exp Ophthalmol 2018 Mar 30. Epub 2018 Mar 30.
    Beijin Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
    Importance: Provision of refractive changes is important to predict eye care needs for aging population.

    Background: To provide 5-year refractive changes in a rural Chinese adult population.

    Design: Population-based longitudinal study. Read More

    Cohort study with 4-year follow-up of myopia and refractive parameters in primary schoolchildren in Baoshan District, Shanghai.
    Clin Exp Ophthalmol 2018 Mar 25. Epub 2018 Mar 25.
    Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
    Importance: Cohort studies could not only reveal associations between change of refractive components and onset/progression of myopia, but also risk factors, which is important for understanding mechanism and providing strategies.

    Background: Prevalence of myopia is high in Shanghai, being reported to be 52.2% in children aged 10 years old. Read More

    Effect of subconjunctival Bevacizumab injection on the outcome of Ahmed glaucoma valve implantation: a randomized control trial.
    Clin Exp Ophthalmol 2018 Mar 23. Epub 2018 Mar 23.
    Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Importance: The effect of subconjunctival Bevacizumab injection on the outcome of Ahmed glaucoma valve (AGV) implantation.

    Background: Evaluation of efficacy and safety of subconjunctival Bevacizumab injection adjunctive to AGV implantation.

    Design: Prospective and randomized clinical trial. Read More

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