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    3141 results match your criteria Clinical and Experimental Ophthalmology[Journal]

    1 OF 63

    Longitudinal evaluation of posterior corneal changes after LASIK in high myopia: a swept-source optical coherence tomography study.
    Clin Exp Ophthalmol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
    LASIK intends to decrease the corneal power by increasing the radius of corneal curvature in myopic correction. Though it does not directly affect the posterior corneal surface, modification is not unexpected since LASIK can weaken the cornea especially in high myopic correction. Read More

    Swept source optical coherence tomography findings of tuberous sclerosis associated retinal astrocytoma.
    Clin Exp Ophthalmol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Ophthalmology, Aga Khan University Hospital, Pakistan.
    Retinal astrocytomas are low-grade neoplasms, typically of non-aggressive nature. Tumor characteristics may vary greatly and they most often occur in association with tuberous sclerosis. Less commonly, astrocytomas may occur with neurofibromatosis or they may be sporadic. Read More

    Acute crocodile tear syndrome without antecedant facial nerve palsy.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Ophthalmology, Royal Melbourne Hospital, Parkville, VIC, Australia.
    Crocodile tear syndrome (CTS) is a rare symptom characterized by excessive unilateral tearing occurring with gustatory stimuli known to develop as a sequel of facial nerve involvement as evident by facial palsy on the affected side.(1) CTS may more rarely occur without antecedent facial palsy with only four cases described in English literature.(2). Read More

    Investigation of corneal endothelial changes post selective laser trabeculoplasty.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Ophthalmology, Westmead Hospital, NSW, Australia.
    Importance: Transient corneal endothelial changes are routinely noted on slit-lamp examination immediately following selective laser trabeculoplasty (SLT).

    Background: To determine the mechanism of the transient corneal endothelial changes observed following SLT.

    Design: University laboratory based observational study SAMPLES: Ten corneas from six human cadaveric donors. Read More

    Retraction gonioscopy, a novel method in the diagnosis of cyclodialysis clefts.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Ophthalmology, Counties Manukau DHB, Auckland, New Zealand.
    Clinical examination remains the gold standard in the diagnosis of a cyclodialysis cleft. This could be challenging especially in the presence of folds in Descemet's membrane, hyphema, corneal edema, peripheral anterior synechiae or a shallow anterior chamber.. Read More

    Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
    Background: Neuropeptide Y (NPY) is a neuromodulator that is expressed in the retina. Increasing evidence suggests that NPY has pronounced anti-inflammatory effects, which might depend on the inhibition of dipeptidyl-peptidase-IV (DPP-IV). The aim of this study was to investigate the impact of type 1 diabetes mellitus (DM) and sitagliptin, a DPP-IV inhibitor, on the NPY system in the retina using an animal model. Read More

    Comparison of ICare tonometry to Goldman tonometry for the measurement of intraocular pressure changes following intravitreal anti-VEGF injection.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Glaucoma Unit, Sydney Eye Hospital, Sydney, Australia.
    In developed countries, age-related macular degeneration (AMD) is a leading cause of visual impairment, particularly in its neovascular form.Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is the standard of care for wet AMD. Inspite of the small intravitreal bolus of 0. Read More

    Ocular protrusion in sitting and supine position.
    Clin Exp Ophthalmol 2018 Feb 11. Epub 2018 Feb 11.
    Department of Ophthalmology, University of California Los Angeles, Los Angeles, California, USA.
    Thyroid eye disease (TED) is characterized in most cases by an expansion in the fat and/or muscle in the orbit (1). Being an enclosed and fixed space, such alterations would be presumed to result in changes to intra-orbital pressure (2) and in compliance of the orbit, leading to decreased retro-displacement of the orbit with supine positioning (3,4). Read More

    Vision loss secondary to orbital extension of rhabdomyosarcoma in an adult.
    Clin Exp Ophthalmol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Ophthalmology, University of Florida, Gainesville, FL, USA.
    A 57 year old African American woman presented with a six-month history of progressively worsening right-sided frontal headaches, nasal obstruction with epistaxis, cough, and vision loss of the right eye. She was treated for presumed sinusitis with antibiotics, steroid spray, and a decongestant without relief. Read More

    Pseduo double XEN: a complication of XEN45 stent placement technique.
    Clin Exp Ophthalmol 2018 Feb 9. Epub 2018 Feb 9.
    Manchester Royal Eye Hospital, Manchester, UK.
    The XEN® 45 Gel Stent (Allergan, Dublin, Ireland) is a device for the treatment of glaucoma and is classified amongst the Micro Invasive Glaucoma Surgery (MIGS) devices. The device consists of a gelatin based tube, measuring 6mm in length with a 45µm internal diameter. Read More

    Fetal bovine serum can reduce toxicity of indocyanine green, brilliant blue G and trypan blue in ARPE-19 cellular model that suggests new surgical staining protocols for internal limiting membrane peeling procedure.
    Clin Exp Ophthalmol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, R.O.C.
    Background: To investigate and compare the cytotoxicity of indocyanine green (ICG), brilliant blue G (BBG) and trypan blue (TB) using ARPE-19 cells that have been pre-treated/post- treated with balanced salt solution (BSS) or fetal bovine serum (FBS).

    Methods: The cultured human retina pigment epithelium (RPE) ARPE-19 cells were pre-treated/post-treated with BSS or FBS (represent the autologous serum in clinic) in parallel with cells being soaked with various concentrations of ICG, BBG, and TB. The cells were then assessed for viability, growth rate, reactive oxygen species (ROS) level, mitochondrial (MT) membrane potential (Δψ) and MT mass as cytotoxic indices. Read More

    Region-specific ischemia, neovascularization and macular edema in treatment-naïve proliferative diabetic retinopathy.
    Clin Exp Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.
    Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.
    Importance: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease.

    Background: To investigate non-perfusion, neovascularization, and macular edema.

    Design: A cross-sectional, observational, non-randomized study. Read More

    The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation, diagnosis and outcomes (2009-2016).
    Clin Exp Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.
    The Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
    Importance: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis.

    Background: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period.

    Design: Retrospective observational consecutive case series. Read More

    Does including colour-blind men enhance search and rescue teams?
    Clin Exp Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.
    Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia.
    Dating back many years there are anecdotal reports that persons with colour-vision deficits (CVD) have unusual abilities to locate camouflaged installations not otherwise apparent to individuals with normal trichromatic colour vision (nCV).. Read More

    Metastasis to the extraocular muscles: a case report, literature review and pooled data analysis.
    Clin Exp Ophthalmol 2018 Feb 2. Epub 2018 Feb 2.
    Royal North Shore Hospital, Sydney, Australia.
    Metastasis to the extraocular muscles (EOM) is rare. The existing literature comprises only of isolated case reports therefore a summative description of these lesions is lacking. This study presents a case of bilateral rectus muscle metastasis from malignant melanoma. Read More

    Surfboard-related intraorbital foreign bodies - a case series and radiological considerations.
    Clin Exp Ophthalmol 2018 Feb 2. Epub 2018 Feb 2.
    Royal North Shore Hospital, Sydney, Australia.
    Surfing is associated with a risk of trauma and the majority of these involve the head and neck. Increasingly surfboard-related eye injuries are being reported and some cases describe devastating ocular sequelae. Read More

    Electron microscopic findings of an explanted retropupillary Artisan lens three years after implantation.
    Clin Exp Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Oxford Eye Hospital, University of Oxford, John Radcliffe Hospital, Oxford, UK.
    Retropupillary fixation of the Artisan iris claw lens (Ophtec, Groningen, Netherlands) has been shown to be a very useful option in the setting of intraocular lens (IOL) implantation where capsular support is lacking, and giving good visual and refractive outcomes in children (1). Read More

    Retinopathy of prematurity: the high cost of screening regional and remote infants.
    Clin Exp Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    University of Queensland, School of Medicine, Brisbane, Australia.
    Importance: Demand for Retinopathy of Prematurity screening, is increasing for infants born at rural and regional hospitals where the service is not generally available. The health system cost for screening regional/remote infants has not been reported.

    Background: The objective of this study is to evaluate the cost of Retinopathy of Prematurity screening at a large centralised tertiary neonatal service for infants from regional/rural hospitals. Read More

    Bevacizumab and Bleomycin combination for treatment of orbital lymphatico-venous malformation recalcitrant to sclerosing therapy alone.
    Clin Exp Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Stein Eye Institute, Division of Orbital and Oculoplastic Surgery, University of California, Los Angeles, CA, USA.
    Orbital lymphatico-venous malformations (LVMs) represent a spectrum of disease from lymphatic dominant to venous dominant lesions, and present unique, challenging management issues both at the lymphatic and venous dominant ends. Read More

    Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Eye & Vision Health, College of Medicine & Public Health, Flinders University, Adelaide, Australia.
    Background: Over-production of reactive oxygen species (ROS) and resulting oxidative stress contribute to retinal damage in vascular diseases that include diabetic retinopathy, retinopathy of prematurity and major retinal vessel occlusions. NADPH oxidase (Nox) proteins are professional ROS-generating enzymes, and therapeutic targeting in these diseases has strong appeal. Pharmacological inhibition of Nox4 reduces the severity of experimental retinal vasculopathy. Read More

    Diet soft drink is associated with increased odds of proliferative diabetic retinopathy.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Australia.
    Importance: While consumption of soft drink may increase risk of cardiovascular disease, the relationship between soft drink consumption and diabetes complications is unknown.

    Background: To explore the association between regular and diet soft drink consumption, and diabetic retinopathy (DR) and diabetic macular edema (DME).

    Design: Clinical, cross-sectional study PARTICIPANTS: Adult patients with diabetes recruited from a tertiary eye hospital (Melbourne, Australia) answered a Food Frequency Questionnaire. Read More

    Exploring the frequency and location of prescribing errors in the use of topical glaucoma medications.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Department of Ophthalmology, Nottingham University Hospital, Nottingham, UK.
    Importance: Very little is known about healthcare professional related prescribing errors within the glaucoma setting.

    Background: This study aims to quantify these errors and to explore where they occur along the prescribing pathway.

    Design: Cross-sectional study of patients attending a specialty glaucoma clinic over a 5-month period. Read More

    Incidence of retinal vein occlusion in open-angle glaucoma: a nationwide, population-based study using the Korean Health Insurance Review and Assessment database.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Importance: We determined the association between retinal vein occlusion (RVO) and open-angle glaucoma (OAG) in a Korean population by reviewing a dataset obtained from the Korean Health Insurance Review and Assessment (HIRA).

    Background: To compare the RVO incidence for OAG patients with that for the general population in order to determine the association between RVO and OAG.

    Design: Nationwide population-based retrospective study. Read More

    Clinical outcomes with distance-dominant multifocal and monofocal intraocular lenses in post-LASIK cataract surgery planned using an intraoperative aberrometer.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Science in Vision, Akron, NY, USA.
    Importance Studies evaluating the clinical benefits of intraoperative aberrometry in cataract surgery are limited.

    Background: The study was designed to determine whether intraoperative aberrometry (IA) improved clinical outcomes of post-LASIK cataract surgery with different intraocular lenses (IOL) implanted. Design A retrospective chart review of clinical outcomes from one surgeon at one surgical center was conducted. Read More

    Paracentral acute middle maculopathy associated with severe vision loss following vitrectomy for vitreous haemorrhage.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Tasmanian Eye Institute, Tasmania, Australia.
    We read with interest the report of 10 cases of paracentral acute middle maculopathy (PAMM) in patients with severe vision loss post cataract surgery by Creese et al.and the accompanied editorial by Chenin this journal. We thank the authors for their contribution and wish to report on a similar recent case of PAMM post retinal surgery. Read More

    Altered proportion of CCR2and CX3CR1circulating monocytes in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.
    Background: We investigated the expression of chemokine receptors CCR2 and CX3CR1 on circulating monocyte subsets in patients with neovascular age-related macular degeneration and patients with polypoidal choroidal vasculopathy.

    Methods: We recruited patients with neovascular age-related macular degeneration, patients with polypoidal choroidal vasculopathy, and age-matched healthy controls for this prospective case-control study. All participants underwent comprehensive clinical examination and imaging. Read More

    The enduring effect of laser iridoplasty.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Capital Eye Specialists, Wellington, New Zealand.
    In primary angle closure (PAC), where peripheral iridotomy has failed to open the iridocorneal angles, laser iridoplasty (LI) is an option to open the angle further. Iridoplasty causes iris thinning as well as circumferential and radial contraction of the peripheral iris, pulling it away from trabecular meshwork. Read More

    Descemet membrane endothelial keratoplasty developing spontaneous 'malignant glaucoma' secondary to gas misdirection.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Singapore Eye Research Institute, Singapore, Singapore.
    Descemet membrane endothelial keratoplasty (DMEK) is increasingly being performed in eyes with corneal decompensation secondary to endothelial disease.The advantages of DMEK include faster visual recovery and a lower immune rejection rate.. Read More

    Association of long-term glycaemic control on tear break up times and dry eye symptoms in Chinese patients with type 2 diabetes.
    Clin Exp Ophthalmol 2018 Jan 18. Epub 2018 Jan 18.
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore.
    Importance Diabetes mellitus is known to be associated with dry eye syndrome (DES), but the effects of long term glycaemic control on tear film metrics and dry eye symptoms are not known in the Chinese population.

    Background: To evaluate tear film stability and dry eye symptoms and their associations with systemic risk factors in Chinese patients with type 2 diabetes (T2DM) Design Cross-sectional study set at the Lo Fong Siu Po Eye Centre (Grantham Hospital), Hong Kong. Read More

    Randomized controlled trial evaluating a novel community eye care programme for elderly individuals with visual impairment.
    Clin Exp Ophthalmol 2017 Dec 28. Epub 2017 Dec 28.
    Singapore National Eye Centre, Singapore.
    Importance: The novel intervention was effective at improving compliance to appropriate tertiary eye care after community eye screening.

    Background: Elderly individuals from low socio-economic background with visual impairment (VI) often do not attend tertiary care, even if significant eye diseases are detected while in the community. We evaluate a novel incentive care scheme (ICS) to improve compliance to appropriate follow-up after community eye screening. Read More

    Evolution of optic nerve photography for glaucoma screening: a review.
    Clin Exp Ophthalmol 2017 Dec 27. Epub 2017 Dec 27.
    Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.
    Visual evaluation of the optic nerve has been one of the earliest and most widely used methods to evaluate patients for glaucoma. Photography has proven very useful for documentation of the nerve's appearance at a given time, allowing more detailed scrutiny then, and later comparison for change. Photography serves as the basis for real-time or non-simultaneous review in telemedicine and screening events allowing fundus and optic nerve evaluation by experts elsewhere. Read More

    Applications of corneal topography and tomography: a review.
    Clin Exp Ophthalmol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
    Corneal imaging is essential for diagnosing and management of a wide variety of ocular diseases. Corneal topography is used to characterize the shape of the cornea, specifically, the anterior surface of the cornea. Most corneal topographical systems are based on Placido disc that analyse rings that are reflected off the corneal surface. Read More

    Corneal hysteresis and anterior segment optical coherence tomography anatomical parameters in primary angle closure suspects.
    Clin Exp Ophthalmol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.
    Importance: Corneal hysteresis (CH) is a dynamic marker of structural and functional changes in the cornea associated with intraocular pressure (IOP) and central corneal thickness, but its utility in assessing primary angle closure suspects (PACS) has not been fully elucidated.

    Background: This study assesses if anterior segment measurements correlate with CH in PACS patients.

    Design: IRB-approved retrospective review of imaging and records at a university practice. Read More

    Comparative study of femtosecond laser-assisted cataract surgery and conventional phacoemulsification in vitrectomized eyes.
    Clin Exp Ophthalmol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
    Importance: To compare the safety and outcomes of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification in post-vitrectomy eyes.

    Background: To compare visual outcomes and adverse outcomes of FLACS and conventional phacoemulsification in vitrectomized eyes.

    Design: Single surgeon, retrospective study set in a private clinic in Auckland, New Zealand. Read More

    Relationship between reticular pseudodrusen and choroidal thickness in intermediate age-related macular degeneration.
    Clin Exp Ophthalmol 2017 Dec 13. Epub 2017 Dec 13.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
    Importance: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their aetiology remains unknown. RPD have been associated with reduced choroidal thickness (ChT) but most studies are limited by small sample size and varying severity of AMD.

    Background: To investigate the relationship between choroidal thickness and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. Read More

    Primary bilateral uveal melanoma: a population-based study and systematic review.
    Clin Exp Ophthalmol 2017 Dec 8. Epub 2017 Dec 8.
    Department of Dermatology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
    Importance: Primary bilateral uveal melanoma (UM) is a rare and incompletely described entity. It is not known how these patients compare to those with unilateral UM.

    Background: We sought to comprehensively characterize and compare patients with primary bilateral and unilateral UM. Read More

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