3,180 results match your criteria Clinical and Experimental Obstetrics & Gynecology [Journal]


Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage.

Int J Gynaecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Objective: To determine whether term fetal membranes from transabdominal cerclage (TAC) patients have favorable characteristics compared with membranes from patients without TAC.

Methods: A prospective study of consecutive pregnant women who had undergone TAC and were delivered by elective cesarean after 37 weeks before the onset of labor at Cliniques universitaires Saint-Luc, Brussels, between January 2015 and June 2016. Membranes were collected from two areas: overlying the cervix and located far from the cervix. Read More

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http://dx.doi.org/10.1002/ijgo.12826DOI Listing

Variables Associated with Endometriosis-related Pain: A Pilot Study using a Visual Analogue Scale.

Rev Bras Ginecol Obstet 2019 Mar 16;41(3):170-175. Epub 2019 Apr 16.

University of Siena, Siena, Italy.

Objective:  Endometriosis is a complex disease, and pain is an important component of the syndrome. One of the most used methods to assess pain is the visual analogue scale (VAS). The aim of the present research was to study the pain experienced by patients who referred to our unit for endometriosis, using the VAS to understand the variables that could influence it. Read More

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http://dx.doi.org/10.1055/s-0039-1679879DOI Listing
March 2019
1 Read

Determination of the chemical components and phospholipids of velvet antler using UPLC/QTOF-MS coupled with UNIFI software.

Exp Ther Med 2019 May 12;17(5):3789-3799. Epub 2019 Mar 12.

Department of Natural Medicinal Chemistry, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.

Velvet antler, which exhibits immune and growth enhancing effects, is commonly used in a variety of Asian health care products, but its complex components remain unknown. The current study analyzed extracts using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry in the MS mode. Automated detection and data filtering were performed using UNIFI software and peaks were compared with a proprietary scientific library (Traditional Medicine Library; TML). Read More

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http://dx.doi.org/10.3892/etm.2019.7372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447902PMC

Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome.

Int J Cardiol 2019 Apr 4. Epub 2019 Apr 4.

Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy. Electronic address:

Background: The adult mammalian heart retains residual regenerative capability via endogenous cardiac progenitor cell (CPC) activation and cardiomyocyte proliferation. We previously reported the paracrine cardioprotective capacity of human amniotic fluid-derived stem cells (hAFS) following ischemia or cardiotoxicity. Here we analyse the potential of hAFS secretome fractions for cardiac regeneration and future clinical translation. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.04.011DOI Listing

Mutational diversity and therapy response in breast cancer - a sequencing analysis in the neoadjuvant GeparSepto trial.

Clin Cancer Res 2019 Apr 12. Epub 2019 Apr 12.

Charité - Universitätsmedizin Berlin.

Purpose: Next-generation-sequencing (NGS) can be used for comprehensive investigation of molecular events in breast cancer (BC). We evaluated the relevance of genomic alterations for response to neoadjuvant chemotherapy (NACT) in the GeparSepto trial.

Experimental Design: 851 pretherapeutic FFPE core biopsies from GeparSepto study were sequenced. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3258DOI Listing
April 2019
1 Read

Application of Artificial Intelligence for Preoperative Diagnostic and Prognostic Prediction in Epithelial Ovarian Cancer Based on Blood Biomarkers.

Clin Cancer Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

We aimed to develop an ovarian cancer-specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers. Overall, 334 patients with epithelial ovarian cancer (EOC) and 101 patients with benign ovarian tumors were randomly assigned to "training" and "test" cohorts. Seven supervised machine learning classifiers, including Gradient Boosting Machine (GBM), Support Vector Machine, Random Forest (RF), Conditional RF (CRF), Naïve Bayes, Neural Network, and Elastic Net, were used to derive diagnostic and prognostic information from 32 parameters commonly available from pretreatment peripheral blood tests and age. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3378DOI Listing
April 2019
2 Reads

Comparing birth experience and birth outcome of vaginal births between induced and spontaneous onset of labour: a prospective study.

Arch Gynecol Obstet 2019 Apr 11. Epub 2019 Apr 11.

Clinic for Gynecology and Obstetrics, HELIOS University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany.

Purpose: In developed countries, around 25% of all births involve labour induction. Studies have indicated that labour induction negatively influences the birth experience as well as the birth process. However, the impact of labour induction when only considering vaginal deliveries has not been studied yet, which was the purpose of the present study. Read More

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http://dx.doi.org/10.1007/s00404-019-05150-8DOI Listing

Delayed delivery of the second twin: Case report and literature review of diamniotic dichorionic twin pregnancy with very early preterm premature rupture of membranes.

Case Rep Womens Health 2019 Apr 19;22:e00104. Epub 2019 Mar 19.

Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, Università di Pisa, Italy.

In multiple pregnancies with threatened premature delivery or preterm premature rupture of membranes (pPROM) of a single sac, prolonging pregnancy after the delivery of the first baby may improve the chances of survival of the second baby. We report the delayed delivery of a second baby in a twin pregnancy with pPROM and very premature delivery of the first baby. This condition is exceptional and there are no validated medical protocols for its management; the scientific evidence is still controversial. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439313PMC
April 2019
1 Read

The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma.

Front Pharmacol 2019 27;10:200. Epub 2019 Mar 27.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is associated with a median overall survival (mOS) of 16-21 months. Our previous work found a negative association between advanced aging and the survival benefit after treatment with immunotherapy in an experimental brain tumor model. Given the recent phase III clinical success of immunotherapy in patients with many types of cancer, but not for patients with GBM, we hypothesize that aging enhances immunosuppression in the brain and contributes to the lack of efficacy for immunotherapy to improve mOS in patients with malignant glioma. Read More

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http://dx.doi.org/10.3389/fphar.2019.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446059PMC

Preterm birth: seven-year retrospective study in a single centre population.

Ital J Pediatr 2019 Apr 11;45(1):45. Epub 2019 Apr 11.

Obstetrics and Gynecology Unit, Department of Human Pathology of Adult and Childhood "G. Barresi", University Hospital "G. Martino", via Consolare Valeria 1, Gazzi, Messina, Italy.

Background: Preterm birth is a health and social problem, considered the leading cause of neonatal mortality worldwide. It is associated with higher rates of neurodevelopmental morbidity, sensorineural impairments and other complications. The aim of the study was to describe the incidence and the major risk factors associated with preterm birth. Read More

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http://dx.doi.org/10.1186/s13052-019-0643-9DOI Listing

Anticancer Activities of L. in Experimental Breast Carcinoma in Vivo and in Vitro.

Int J Mol Sci 2019 Apr 9;20(7). Epub 2019 Apr 9.

Weill Cornell Medicine in Qatar, Qatar Foundation-Education City, Doha 24144, Qatar.

Naturally-occurring mixtures of phytochemicals present in plant foods are proposed to possess tumor-suppressive activities. In this work, we aimed to evaluate the antitumor effects of L. in in vivo and in vitro mammary carcinoma models. Read More

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http://dx.doi.org/10.3390/ijms20071749DOI Listing
April 2019
2.862 Impact Factor

Genes involved in hormone metabolism and cellular response in human ovarian granulosa cells.

J Biol Regul Homeost Agents 2019 Mar-Apr,;33(2):461-468

Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland.

Endocrinal interactions are one of the most crucial regulatory mechanisms that maintain the state of homeostasis in humans. Processes such as oogenesis, folliculogenesis, menstruation and pregnancy remain under hormonal control. A key role in folliculogenesis is played by granulosa cells. Read More

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April 2019
5 Reads

Survival Following Chemotherapy in Ovarian Clear Cell Carcinoma is Not Associated with Pathological Misclassification of Tumor Histotype.

Clin Cancer Res 2019 Apr 9. Epub 2019 Apr 9.

Cancer Genetics and Genomics Laboratory and Austrialian Ovarian Cancer Study, Peter MacCallum Cancer Centre

Purpose: Although ovarian clear cell carcinomas (OCCCs) are commonly resistant to platinum based chemotherapy, good clinical outcomes are observed in a subset of patients. The explanation for this is unknown but may be due to misclassification of high-grade serous ovarian cancer (HGSOC) as OCCC or mixed histology.

Experimental Design: To discover potential biomarkers of survival benefit following platinum based chemotherapy, we ascertained a cohort of 68 Japanese and Australian patients in whom progression-free survival (PFS) and overall survival (OS) could be assessed. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3691DOI Listing
April 2019
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A Practical Guide to miRNA Target Prediction.

Methods Mol Biol 2019 ;1970:1-13

Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.

MicroRNAs (miRNAs) are small endogenous noncoding RNA molecules that posttranscriptionally regulate gene expression. Since their discovery, a huge number of miRNAs have been identified in a wide range of species. Through binding to the 3' UTR of mRNA, miRNA can block translation or stimulate degradation of the targeted mRNA, thus affecting nearly all biological processes. Read More

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http://dx.doi.org/10.1007/978-1-4939-9207-2_1DOI Listing
January 2019

Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention.

Curr Pharm Biotechnol 2019 Apr 8. Epub 2019 Apr 8.

Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex Hacienda la Concepción s/n, ctra. Pachuca-Tilcuautla, Hidalgo 42060. Mexico.

Background: Worldwide the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries with socioeconomic differences, which have considered implementing alternative healthcare strategies to prevent and reduce preterm births. Read More

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http://dx.doi.org/10.2174/1389201020666190408112013DOI Listing
April 2019
1 Read

Estrogen stimulates female cancer progression by inducing myeloid-derived suppressive cells: investigations on pregnant and non-pregnant experimental models.

Oncotarget 2019 Mar 8;10(20):1887-1902. Epub 2019 Mar 8.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: To investigate the clinical implications of 17β-estradiol (E2) in estrogen receptor α (ERα)-negative female cancer progression as well as the underlying biological mechanisms.

Methods: Clinical data from 306 locally-advanced cervical cancer (stage IIB-IVA) patients were analyzed in order to investigate the relationships between age, serum E2 levels, and treatment outcomes. Clinical samples, ERα-negative cervical and breast cancer cell lines, and mouse xenograft models of cervical and breast cancers were employed in order to elucidate the mechanisms responsible for the E2- and pregnancy-mediated progression of cervical and breast cancers, with a focus on the role of myeloid-derived suppressor cells (MDSC). Read More

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http://dx.doi.org/10.18632/oncotarget.26711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443012PMC
March 2019
2 Reads

Calprotectin in pregnancy and pregnancy-associated diseases: a systematic review and prospective cohort study.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology, Ruhr-Universität Bochum - Marien Hospital Herne, Hölkeskampring 40, 44625, Herne, Germany.

Purpose: Calprotectin, a marker of acute and chronic inflammation, may play a role in pregnancy-associated disorders. We aimed to summarize available clinical data on calprotectin in pregnancy and to establish normal values of calprotectin during the course of pregnancy.

Methods: We performed a systematic review of the databases PubMed and Cochrane Central Register of Controlled Trials to identify experimental and clinical evidence assessing the role of calprotectin in pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-019-05134-8DOI Listing
April 2019
2 Reads

MicroRNA let-7g acts as tumor suppressor and predictive biomarker for chemoresistance in human epithelial ovarian cancer.

Sci Rep 2019 Apr 5;9(1):5668. Epub 2019 Apr 5.

Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Campus Salvatore Venuta -Viale Europa, 88100, Catanzaro, Italy.

Remarkable deregulation of microRNAs has been demonstrated in epithelial ovarian cancer (EOC). In particular, some of the let-7 miRNA family members have been proposed as tumor suppressors. Here, we explored the functional roles of let-7g in EOC. Read More

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http://dx.doi.org/10.1038/s41598-019-42221-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450929PMC
April 2019
1 Read

On the use and abuse of register studies: The case of menopausal hormone therapy.

Maturitas 2019 Mar 13. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, University Women's Hospital, Bern, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S03785122193016
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http://dx.doi.org/10.1016/j.maturitas.2019.03.009DOI Listing
March 2019
4 Reads

Prevalence and role of HER2 mutations in cancer.

Pharmacol Ther 2019 Apr 2. Epub 2019 Apr 2.

Human Oncology & Pathogenesis Program (HOPP), Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

HER2 activating mutations act as oncogenic drivers in various cancer types. In the clinic, they can be identified by next generation sequencing (NGS) in either tumor biopsies or circulating cell-free DNA (cfDNA). Preclinical data indicate that HER2 "hot spot" mutations are constitutively active, have transforming capacity in vitro and in vivo and show variable sensitivity to anti-HER2 based therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193005
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http://dx.doi.org/10.1016/j.pharmthera.2019.03.010DOI Listing
April 2019
3 Reads

Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model.

Front Endocrinol (Lausanne) 2019 21;10:165. Epub 2019 Mar 21.

Department of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

The anti-angiogenic soluble fms-like tyrosine kinase 1 (sFLT1) is one of the candidates in the progression of preeclampsia, often associated with fetal growth restriction (FGR). Therapeutic agents against preeclampsia with/without FGR, as well as adequate transgenic sFLT1 mouse models for testing such agents, are still missing. Much is known about sFLT1-mediated endothelial dysfunction in several tissues; however, the influence of sFLT1 on placental and fetal development is currently unknown. Read More

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http://dx.doi.org/10.3389/fendo.2019.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437783PMC
March 2019
1 Read

Epidemiology of invasive and non-invasive pneumococcal infections in hospitalised adult patients in a Lebanese medical centre, 2006-2015.

J Infect Public Health 2019 Apr 1. Epub 2019 Apr 1.

Centre for Infectious Diseases Research, American University of Beirut, Riad El-Solh, Beirut, Lebanon; Department of Paediatrics and Adolescent Medicine, Division of Paediatric Infectious Diseases, American University of Beirut, Riad El-Solh, Beirut, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Riad El-Solh, Beirut, Lebanon. Electronic address:

This is a retrospective medical file review of adult inpatients with Streptococcus pneumoniae infections admitted to a Lebanese hospital between 2006 and 2015. We revisited the clinical scenarios of these infections in view of increasing antibiotic resistance in Lebanon. One hundred and three patients were included; 92% were eligible for pneumococcal vaccination, yet none were vaccinated. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.003DOI Listing

Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes.

Toxicol Lett 2019 Jun 30;308:50-55. Epub 2019 Mar 30.

Department of Public Health, Division of Environmental Health Science, School of Health Sciences and Practice, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, New York, 10595, USA; Department of Cell Biology and Anatomy, New York Medical College, 40 Sunshine Cottage Rd, Valhalla, New York, 10595, USA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Rutgers-Robert Wood Johnson Medical School, Piscataway, 675 Hoes Ln W, New Jersey, 08854, USA.

Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide and potential chemical threat agent. Signs of TMDT poisoning include convulsions which can progress into status epilepticus and death. Although clinical reports clearly show that poisoning via food and drink is the main route of exposure, experimental studies have primarily utilized parenteral routes. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.03.014DOI Listing
June 2019
3 Reads

Joint consensus on anesthesia in urologic and gynecologic robotic surgery: specific issues in management from a task force of the SIAARTI, SIGO, and SIU.

Minerva Anestesiol 2019 Mar 29. Epub 2019 Mar 29.

Department of Critical Care Area Monaldi Hospital, Ospedali dei Colli, Naples, Italy.

Introduction: Proper management of patients undergoing robotic-assisted urologic and gynecologic surgery must consider a series of peculiarities in the procedures for anesthesiology, critical care medicine, respiratory care, and pain management. Although the indications for robotic-assisted urogynecologic surgeries have increased in recent years, specific guidance documents are still lacking.

Evidence Acquisition: Multidisciplinary group including anesthesiologists, gynecologists, urologists, and a clinical epidemiologist systematically reviewed the relevant literature and provided a set of recommendations and unmet needs on peculiar aspects of anesthesia in this field. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13360-3DOI Listing
March 2019
1 Read

Correlation of miR-21 and BNP with pregnancy-induced hypertension complicated with heart failure and the diagnostic value.

Exp Ther Med 2019 Apr 19;17(4):3129-3135. Epub 2019 Feb 19.

Department of Obstetrics, Yanan Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650051, P.R. China.

Correlation of miR-21 and B-type natriuretic peptide (BNP) with pregnancy-induced hypertension (PIH) complicated with heart failure and the diagnostic value was investigated. Sixty patients with PIH complicated with heart failure admitted to Affiliated Hospital of Chengde Medical University from July 2016 to July 2017 were enrolled as the experimental group, and 35 normal pregnant women as the control group. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) method was used to determine the expression level of plasma miR-21 expression level. Read More

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http://dx.doi.org/10.3892/etm.2019.7286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434261PMC
April 2019
2 Reads

Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study.

Clin Cancer Res 2019 Apr 1. Epub 2019 Apr 1.

Medical oncoloy, CITOHL, Institut de Cancérologie des Hospices Civils de Lyon

Background: Regarding CA-125 longitudinal kinetics during chemotherapy, the actual predictive value of the Gynecology Cancer InterGroup (GCIG) CA-125 response criterion is questioned. The modeled CA-125 elimination rate constant KELIM exhibited higher prognostic value in recurrent ovarian cancer patients enrolled in CALYPSO trial. The objective was to validate the higher predictive & prognostic values of KELIM during first line treatments. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3335DOI Listing

Oral dehydroepiandrosterone restores ß-endorphin response to OGTT in early and late postmenopause.

Gynecol Endocrinol 2019 Apr 2:1-5. Epub 2019 Apr 2.

a Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics , University of Pisa , Pisa , Italy.

ß-endorphin is a neuropeptide involved in several brain functions: its plasma levels are higher in obese women and its release increases after oral glucose tolerance test (OGTT) in normal or obese women. The study included 46 healthy women and evaluated the effect of oral dehydroepiandrosterone [DHEA] (50 mg/day) in early postmenopausal women (50-55 years) both of normal weight (group A, n = 12, BMI = 22.1 ± 0. Read More

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http://dx.doi.org/10.1080/09513590.2019.1590548DOI Listing
April 2019
1 Read

Effects of early umbilical cord clamping versus delayed clamping on maternal and neonatal outcomes: a Jordanian study.

J Matern Fetal Neonatal Med 2019 Apr 15:1-7. Epub 2019 Apr 15.

d Maternal, Newborn and Families Research Collaborative , Menzies Health Institute Queensland, Griffith University , Nathan , Australia.

Objective: To compare the effects of early versus delayed cord clamping of term births on maternal and neonatal outcomes.

Method: A quasi-experimental study was conducted at the Jordan University Hospital in Amman. One hundred twenty-eight mothers expecting a full-term singleton baby were assigned to delayed cord clamping (90 seconds) or early cord clamping (<30 seconds). Read More

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http://dx.doi.org/10.1080/14767058.2019.1602603DOI Listing
April 2019
2 Reads

Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies.

J Reprod Immunol 2019 Apr 22;132:42-48. Epub 2019 Mar 22.

Division of Obstetrics and Gynaecology, Oslo University Hospital, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address:

Uteroplacental acute atherosis (AA) is a common spiral arterial lesion in preeclampsia, characterized by intramural foam cells, fibrinoid necrosis, and a perivascular immune cell infiltrate. A clear definition of this infiltrate is lacking. Therefore, our aim was to characterize lymphocytes in pre-defined zones regarding spiral arteries with or without AA, from preeclamptic and normotensive pregnancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183034
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http://dx.doi.org/10.1016/j.jri.2019.03.003DOI Listing
April 2019
4 Reads

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer.

Mol Oncol 2019 Mar 30. Epub 2019 Mar 30.

Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlinand Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Metastasis-associated in colon cancer 1 (MACC1) and S100 calcium-binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT-qPCR and digital droplet PCR, respectively. Read More

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http://dx.doi.org/10.1002/1878-0261.12484DOI Listing
March 2019
1 Read

Linking pre-existing biorepositories for medical research: the PopGen 2.0 Network.

J Community Genet 2019 Mar 29. Epub 2019 Mar 29.

Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.

The significance of human biorepositories for modern medical research, particularly for comprehensive population-based genetic analyses, is constantly growing. While large and centralized institutions are usually considered best suited to meet the increasing demand for high-quality "biobanks," most medical research institutions still host rather heterogeneous and fragmented biobanking activities, undertaken by clinical departments with oftentimes rather different scientific scope. Undoubtedly, most clinicians and medical researchers would appreciate infrastructural support in terms of the storage and handling of their biosamples, but they are also likely to expect access to their samples avoiding extensive formal requirements. Read More

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http://dx.doi.org/10.1007/s12687-019-00417-8DOI Listing

A more accurate method to interpret lactate dehydrogenase (LDH) isoenzymes' results in patients with uterine masses.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 19;236:143-147. Epub 2019 Mar 19.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples "Federico II", Naples, Italy.

Objective: Since there are no approved reliable biomarkers for detecting preoperatively uterine sarcoma, lactate dehydrogenase (LDH) isoenzymes are usually required. We first evaluated the role of LDH isoenzymes in detecting uterine sarcoma risk, and then we tried to introduce a model to easily interpret the biochemical results.

Methods: We retrospectively retrieved records of patients who underwent surgical treatment for uterine masses from 2004 to 2016, and we compared data of 2211 patients with a definitive surgical diagnosis of uterine fibroids and 43 with uterine sarcomas. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.017DOI Listing

Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract.

Biomed Microdevices 2019 Mar 29;21(2):36. Epub 2019 Mar 29.

Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP, UK.

Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Read More

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http://dx.doi.org/10.1007/s10544-019-0385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439215PMC

Metabolism of 13C-labeled fatty acids in term human placental explants by liquid chromatography mass spectrometry.

Endocrinology 2019 Mar 28. Epub 2019 Mar 28.

Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Placental lipid transport and metabolism is poorly understood despite its importance for fetal development and life-long health. We aimed to explore fatty acid (FA) processing in human villous placental explants from seven uncomplicated term singleton pregnancies delivered by elective cesarean section. Explants were treated with stable-isotope labeled palmitic acid (13C-PA), oleic acid (13C-OA) or docosahexaenoic acid (13C-DHA) for 3, 24 or 48 hours. Read More

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http://dx.doi.org/10.1210/en.2018-01020DOI Listing
March 2019
1 Read

Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies.

Mol Oncol 2019 Mar 27. Epub 2019 Mar 27.

Laboratory of Genome Integrity, Institute of Molecular Genetics, v.v.i, Academy of Sciences of the Czech Republic, Prague, 14220, Czech Republic.

Radiation and chemotherapy represent standard-of-care cancer treatments. However, most patients eventually experience tumour recurrence, treatment failure and metastatic dissemination with fatal consequences. To elucidate the molecular mechanisms of resistance to radio- and chemo-therapy, we exposed human cancer cell lines (HeLa, MCF-7, and DU145) to clinically-relevant doses of 5-azacytidine or ionizing radiation and compared the transcript profiles of all surviving cell subpopulations, including low-adherent stem-like cells. Read More

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http://dx.doi.org/10.1002/1878-0261.12480DOI Listing
March 2019
3 Reads

Effects of cisplatin on photosensitizer-mediated photodynamic therapy in breast tumor-bearing nude mice.

Obstet Gynecol Sci 2019 Mar 4;62(2):112-119. Epub 2019 Mar 4.

Department of Obstetrics and Gynecology, Chosun University College of Medicine, Gwangju, Korea.

Objective: This study aimed to evaluate the potential effects of cisplatin on photodynamic therapy (PDT) in breast cancer using a breast tumor-bearing mouse model.

Methods: In this study, breast tumor (experimental mammary tumour-6 cell)-bearing nude mice were used as experimental animals. Photolon (photosensitizer, 2. Read More

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http://dx.doi.org/10.5468/ogs.2019.62.2.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422844PMC

Recent advances in understanding and managing adenomyosis.

F1000Res 2019 13;8. Epub 2019 Mar 13.

Obstetrics and Gynecology, Department of Maternity and Child Health, University Hospital Florence, Careggi University Hospital, Florence, Largo Brambilla 3, 50134, Italy.

Adenomyosis is a benign uterine disorder in which endometrial glands and stroma are pathologically demonstrated in the uterine myometrium and it is considered a specific entity in the PALM-COEIN FIGO (polyp; adenomyosis; leiomyoma; malignancy and hyperplasia; coagulopathy; ovulatory dysfunction; endometrial; iatrogenic; and not yet classified - International Federation of Gynecology and Obstetrics) classification of causes of abnormal uterine bleeding (AUB). Although it has always been considered the classic condition of multiparous women over 40 years old who have pain and heavy menstrual bleeding, diagnosed at hysterectomy, the epidemiological scenario has completely changed. Adenomyosis is increasingly identified in young women with pain, AUB, infertility, or no symptoms by using imaging techniques such as transvaginal ultrasound and magnetic resonance. Read More

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http://dx.doi.org/10.12688/f1000research.17242.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419978PMC
March 2019
2 Reads

Role of Oxidative Stress in Maternal and Neonatal Diseases.

Oxid Med Cell Longev 2019;2019:9742764. Epub 2019 Feb 24.

Università degli Studi di Siena, Italy.

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http://dx.doi.org/10.1155/2019/9742764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409029PMC
February 2019

Association Between Year of Birth and 1-Year Survival Among Extremely Preterm Infants in Sweden During 2004-2007 and 2014-2016.

JAMA 2019 03;321(12):1188-1199

Swedish Neonatal Quality Register, Umeå University Hospital, Umeå, Sweden.

Importance: Since 2004-2007, national guidelines and recommendations have been developed for the management of extremely preterm births in Sweden. If and how more uniform management has affected infant survival is unknown.

Objective: To compare survival of extremely preterm infants born during 2004-2007 with survival of infants born during 2014-2016. Read More

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http://dx.doi.org/10.1001/jama.2019.2021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439685PMC
March 2019
35.289 Impact Factor

Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial.

JAMA 2019 03;321(12):1165-1175

Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.

Importance: Preterm infants must establish regular respirations at delivery. Sustained inflations may establish lung volume faster than short inflations.

Objective: To determine whether a ventilation strategy including sustained inflations, compared with standard intermittent positive pressure ventilation, reduces bronchopulmonary dysplasia (BPD) or death at 36 weeks' postmenstrual age without harm in extremely preterm infants. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439695PMC
March 2019
20 Reads
35.289 Impact Factor

Fetal stem cell transplantation and gene therapy.

Best Pract Res Clin Obstet Gynaecol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Science, Intervention and Technology, K57, Division of Obstetrics and Gynecology, Karolinska University Hospital, Huddinge Karolinska Institutet, Stockholm, Sweden. Electronic address:

The present chapter summarizes our current knowledge on fetal stem cell and gene therapy. It focuses on these therapeutic alternatives in regard to past experiences and ongoing and planned studies in humans. Several methodological challenges are discussed that may have wide implications on how these methods could be introduced in clinical practices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216934183024
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http://dx.doi.org/10.1016/j.bpobgyn.2019.02.007DOI Listing
March 2019
7 Reads

Patterns of Failures and Clinical Outcome of Patients with Early-Stage, High-Risk, Node-Negative Endometrial Cancer Treated with Surgery Followed by Adjuvant Platinum-Based Chemotherapy and Vaginal Brachytherapy.

Oncology 2019 Mar 22:1-7. Epub 2019 Mar 22.

Department of Experimental and Clinical Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.

Objective: To assess the clinical outcome of patients with high-risk early-stage endometrial cancer and negative pelvic nodes who received adjuvant platinum-based chemotherapy plus vaginal brachytherapy (VBT).

Methods: This investigation assessed 80 patients who underwent hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy for stage Ib-II, grade 2-3 endometrioid (n = 43) or stage Ia-II nonendometrioid (n = 37) endometrial cancer.

Results: Five-year local control rate, 5-year disease-free survival, and 5-year overall survival were 97, 87, and 97%, respectively, for endometrioid carcinoma, and 66, 50, and 72%, respectively, for nonendometrioid carcinoma. Read More

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http://dx.doi.org/10.1159/000492430DOI Listing
March 2019
1 Read

Controlling metastatic cancer: the role of phytochemicals in cell signaling.

J Cancer Res Clin Oncol 2019 Mar 22. Epub 2019 Mar 22.

Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine and Martin University Hospital, Comenius University in Bratislava, Martin, Slovakia.

Purpose: Cancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation. Read More

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http://dx.doi.org/10.1007/s00432-019-02892-5DOI Listing
March 2019
3.081 Impact Factor

Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?

Free Radic Biol Med 2019 Mar 18. Epub 2019 Mar 18.

Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain.

Oxidative stress is responsible for microvascular complications (hypertension, nephropathy, retinopathy, peripheral neuropathy) of diabetes, which during pregnancy increase both maternal and fetal complications. Chronic hypoxia and hyperglycemia result in increased oxidative stress and decreased antioxidant enzyme activity. However, oxidative stress induces also anti-oxidative reactions both in pregnant diabetes patients and in their fetuses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183264
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.012DOI Listing
March 2019
6 Reads

Peripartum and postpartum outcomes in uncomplicated term pregnancy following ART: a retrospective cohort study from two Italian obstetric units.

Hum Reprod Open 2018 24;2018(3):hoy012. Epub 2018 Jul 24.

Department of Health Sciences, University of Florence, Careggi University Hospital, Largo Brambilla, Florence, Italy.

Study Question: Do singleton uncomplicated term pregnancies conceived by assisted reproductive technology (ART) have adverse peripartum and postpartum outcomes?

Summary Answer: Term pregnancies following ART, even if uncomplicated until birth, have a higher risk of retained placenta and postpartum hemorrhage (PPH).

What Is Known Already: There is consistent evidence that pregnancies following ART have higher incidence of complications during pregnancy. However, few studies specifically investigated birth outcomes in ART term pregnancies. Read More

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http://dx.doi.org/10.1093/hropen/hoy012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276695PMC
July 2018
1 Read

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling.

Circ Res 2019 Mar 21. Epub 2019 Mar 21.

Pharmacology, Shandong University School of Basic Medical Science.

Rationale: Endothelial dysfunction is an important determinant risk factor for the development of hypertension and its complications. Thus, identification of potential therapeutic targets for preventing endothelial dysfunction has major clinical importance. Emerging evidence indicates that epigenetic modifications are closely associated with the regulation of endothelial function. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314032DOI Listing
March 2019
2 Reads
11.019 Impact Factor

[The study of making decision in the timing of delivery for patients of placenta previa through dynamic monitoring the length of cervical canal by perineal ultrasound].

Zhonghua Yi Xue Za Zhi 2019 Mar;99(11):834-837

Department of Obstetrics, Jiaxing Women and Children's Hospital of Wenzhou Medical University, Jiaxing 314000, China.

To investigate the value of dynamic monitoring of cervical canal length by transperineal ultrasonography in the decision-making of the timing of delivery in patients with complete placenta previa, then to provide clinical guidance for complete termination of placenta. A total of 130 patients with complete placenta previa from 28 weeks to 30 weeks of gestation between January 2014 and October 2017 in Jiaxing Maternal and Child Health Hospital were selected. There were 66 patients in the experimental group and 64 in the control group, closely monitor the patient's vital signs, abdominal pain, abdominal distension, vaginal bleeding and fetal intrauterine conditions. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.011.007DOI Listing
March 2019
1 Read

What is the impact of short- and long-term supplementation of either cabergoline or clarithromycin on resolving rat ovarian hyperstimulation syndrome (OHSS) model?

J Obstet Gynaecol 2019 Mar 20:1-8. Epub 2019 Mar 20.

c Department of Biochemistry , Firat University School of Medicine , Elazig , Turkey.

This study aimed to evaluate the effects of coasting, cabergoline and clarithromycin in a rat ovarian hyperstimulation syndrome (OHSS) model. The 42 female Wistar rats were divided into seven groups: control, OHSS (was given 10 IU of pregnant mare serum gonadotropin for 4 consecutive days from day 22 and 30 IU hCG on the fifth day to induce OHSS ), coasting (hCG was applied on the 27th day after gonadotropin injections and the rats were decapitated on the 28th day), Cabergoline (100 mg/kg/d) and clarithromycin (100 mg/kg/d) were given (on the 26th day) with a short-term supplementation (on the 26th day) and long-term supplementation (from the 22nd to the 26th day) groups. The rats were decapitated on the 27th day. Read More

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http://dx.doi.org/10.1080/01443615.2018.1563774DOI Listing
March 2019
6 Reads

Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 12;236:84-93. Epub 2019 Mar 12.

Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands; Korsakoff Center Slingedael, Lelie Care Group, Rotterdam, the Netherlands.

Pregnant women have an increased demand for thiamine. In hyperemesis gravidarum (HG) thiamine rapidly depletes, which can lead to Wernicke's Encephalopathy (WE). Our objective was to systematically review the signs and symptoms of WE in HG. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.006DOI Listing
March 2019
1 Read