3,074 results match your criteria Clinical and Experimental Obstetrics & Gynecology [Journal]


The European registry on obstetric Antiphospholipid syndrome (EUROAPS): A survey of 1000 consecutive cases.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.

Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS).

Methods: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.006DOI Listing
February 2019

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper.

Crit Rev Oncol Hematol 2019 Feb 19;134:39-45. Epub 2018 Dec 19.

Department of Tumor Biology, Center of Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The heterogeneity of metastatic breast cancer (MBC) necessitates novel biomarkers allowing stratification of patients for treatment selection and drug development. We propose to use the prognostic utility of circulating tumor cells (CTCs) for stratification of patients with stage IV disease.

Methods: In a retrospective, pooled analysis of individual patient data from 18 cohorts, including 2436 MBC patients, a CTC threshold of 5 cells per 7. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.004DOI Listing
February 2019

Current Progress in Uterus Transplantation Research in Asia.

J Clin Med 2019 Feb 14;8(2). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 1608582, Japan.

Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. Read More

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http://dx.doi.org/10.3390/jcm8020245DOI Listing
February 2019
1 Read

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid.

FASEB J 2019 Feb 15:fj201802307R. Epub 2019 Feb 15.

Monash Biomedicine Discovery Institute Monash University, Clayton, Victoria, Australia.

The airway remodeling (AWR) associated with chronic allergic airways disease (AAD)/asthma contributes to irreversible airway obstruction. This study compared and combined the antiremodeling and other effects of induced pluripotent stem cell and mesenchymoangioblast-derived mesenchymal stem cells (MCA-MSCs) with the corticosteroid dexamethasone (Dex) in experimental chronic AAD/asthma. Female BALB/c mice subjected to 11 wk of ovalbumin (Ova)-induced chronic AAD were intranasally administered MCA-MSCs (1 × 10 cells/mouse; once weekly on wk 10 and 11), Dex (0. Read More

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http://dx.doi.org/10.1096/fj.201802307RDOI Listing
February 2019

Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing.

J Craniomaxillofac Surg 2019 Jan 22. Epub 2019 Jan 22.

Dicle University, Diyarbakır Technical Sciences Vocational School, Diyarbakır, Turkey.

Aim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model.

Material And Methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.01.023DOI Listing
January 2019

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019

Transcriptomic profile of cell cycle progression genes in human ovarian granulosa cells.

J Biol Regul Homeost Agents 2019 Feb 14;33(1). Epub 2019 Feb 14.

Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland.

The ovarian granulosa cells (GCs) that form the structure of follicle undergo substantial modification during the various stages of human folliculogenesis. These modifications include morphological changes, accompanied by differential expression of genes, encoding proteins which are mainly involved in cell growth, proliferation and differentiation. Recent data bring a new insight into the aspects of GCs' stem-like specificity and plasticity, enabling their prolonged proliferation and differentiation into other cell types. Read More

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February 2019

Lymph node ratio in inguinal lymphadenectomy for squamous cell vulvar cancer: Results from the AGO-CaRE-1 study.

Gynecol Oncol 2019 Feb 11. Epub 2019 Feb 11.

Department of Gynaecology and Gynaecologic Oncology, University Medical Center Hamburg-Eppendorf, Germany; Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

Objective: Lymph node ratio (LNR) can predict treatment outcome and prognosis in patients with solid tumors. Aim of the present analysis was to confirm the concept of using LNR for assessing outcome in patients with vulvar cancer after surgery with inguinal lymphadenectomy in a large multicenter project.

Methods: The AGO-CaRE-1 study multicenter database was used for analysis. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.007DOI Listing
February 2019

Peroxiredoxin-5 is a negative survival predictor in ovarian cancer.

Ginekol Pol 2019 ;90(1):1-6

Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Poland.

Objectives: Peroxiredoxins (PRDXs) constitute a family of antioxidant enzymes which are also involved in the process of carcinogenesis. They are composed of six identified isoforms (PRDX-1-6) and are supposed to play different roles in tumor progression, depending on type of cancer and member of the PRDX family. The aim of the study was to assess the prog- nostic value of PRDXs in ovarian cancer. Read More

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http://dx.doi.org/10.5603/GP.2019.0001DOI Listing
January 2019

Oophorectomy and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers.

Breast Cancer Res Treat 2019 Feb 12. Epub 2019 Feb 12.

Women's College Research Institute, Women's College Hospital, 76 Grenville St., 6th Floor, Toronto, ON, M5S 1B2, Canada.

Purpose: Following a diagnosis of breast cancer, BRCA mutation carriers face an increased risk of developing a second (contralateral) cancer in the unaffected breast. It is important to identify predictors of contralateral cancer in order to make informed decisions about bilateral mastectomy. The impact of bilateral salpingo-oophorectomy (i. Read More

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http://dx.doi.org/10.1007/s10549-019-05162-7DOI Listing
February 2019

Interprofessional "on-call" e-learning for family nurse practitioner students: Preparing for primary care across the life span.

J Am Assoc Nurse Pract 2019 Feb;31(2):104-109

Department of Obstetrics & Gynecology, Reproductive Endocrinology/Infertility, Columbia University Medical Center, New York, New York.

Background And Purpose: Nurse practitioners (NPs) are expected to fill gaps in providing primary care in the United States and need vital skills to meet the growing need for primary care providers. One necessary skill is managing "on-call" clinical questions/concerns by patients across the life span. To date, there are no published studies that address "on-call" simulations for family NP (FNP) students across the life span. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000120DOI Listing
February 2019

The risk of using monoclonal or polyclonal commercial antibodies: controversial results on porcine sperm CD44 receptor identification.

Reprod Domest Anim 2019 Feb 11. Epub 2019 Feb 11.

Department of Clinical and Experimental Medicine (IKE), BKH, Obstetrics and Gynaecology, Faculty of Medicine & Health Sciences, Linköping University, Linköping, Sweden.

Presence of the hyaluronan (hyaluronic acid, HA) receptor CD44 on spermatozoa has been difficult to pursue, mostly obeying to the use of different commercial mono- and/or polyclonal antibodies, often lacking proper controls. Here, we describe how the presence (Western blotting) and specific location (immunocytochemistry) of the CD44 receptor differs in ejaculated pig spermatozoa depending on the type of antibody and protocol used. While we were able to detect binding to spermatozoa and mark its presence in the sperm membrane, the use of blocking peptides clearly indicated that only the monoclonal antibody could confirm the specific presence and location of the CD44 receptor, whereas the polyclonal antibody was detecting multiple presumed CD44 isoforms or degraded proteins thus proving unspecific. Read More

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http://dx.doi.org/10.1111/rda.13415DOI Listing
February 2019

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.

J Inherit Metab Dis 2019 Jan;42(1):5-28

Department of Clinical Genomics, Mayo Clinic, Rochester, New York.

Phosphomannomutase 2 (PMM2-CDG) is the most common congenital disorder of N-glycosylation and is caused by a deficient PMM2 activity. The clinical presentation and the onset of PMM2-CDG vary among affected individuals ranging from a severe antenatal presentation with multisystem involvement to mild adulthood presentation limited to minor neurological involvement. Management of affected patients requires a multidisciplinary approach. Read More

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http://dx.doi.org/10.1002/jimd.12024DOI Listing
January 2019
1 Read

The Connection of the Level of Estradiol in Serum and Obesity with the Endometrial Bleeding in Postmenopausal Women.

Open Access Maced J Med Sci 2019 Jan 13;7(1):88-91. Epub 2019 Jan 13.

University Clinic for Gynaecology and Obstetrics, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Postmenopausis is a period that begins one year after the last menstrual period. Abnormal uterine bleeding could be of different origins.

Aim: This study aimed to determine the association of serum estrogen hormone levels and obesity with the occurrence of endometrial bleeding in post-menopausal women. Read More

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http://dx.doi.org/10.3889/oamjms.2019.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352464PMC
January 2019
1 Read

Women's perceptions of medication use during pregnancy and breastfeeding - a Swedish cross-sectional questionnaire study.

Acta Obstet Gynecol Scand 2019 Feb 10. Epub 2019 Feb 10.

Department of Obstetrics and Gynecology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Introduction: Medication use for different kinds of symptoms and diseases during pregnancy is common. When counseling the pregnant woman, an understanding of her perceptions concerning the use of medication as well as possible associated anxiety and obstacles is important in order to ensure high adherence to the treatment regimen.

Material And Methods: A questionnaire was developed regarding the use of medication, perceptions on use of medication, as well as perceptions about pregnancy outcomes in association with medication use during pregnancy. Read More

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http://dx.doi.org/10.1111/aogs.13570DOI Listing
February 2019
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Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 7. Epub 2019 Feb 7.

INRS-Institut Armand-Frappier, Université du Québec and Biomed Research Center, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis and in regulation of fetal development. A number of studies have implicated the prominent role of serotonin transporter (SERT or 5-HTT) and 5-HT receptor subtypes in placental development and function. Here, in this article we have provided a comprehensive review on the important role of 5-HT homeostasis in pregnancy outcomes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.017DOI Listing
February 2019
1 Read

Menopause: Women should not suffer in silence.

Maturitas 2019 Jan 30. Epub 2019 Jan 30.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1016/j.maturitas.2019.01.014DOI Listing
January 2019

The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.

Reprod Biol Endocrinol 2019 Feb 6;17(1):18. Epub 2019 Feb 6.

Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.

Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation.

Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Read More

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http://dx.doi.org/10.1186/s12958-019-0460-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366097PMC
February 2019

A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer (NEO-ORB).

Clin Cancer Res 2019 Feb 5. Epub 2019 Feb 5.

Medicine, UTSW Simmons Cancer Center

Purpose: Addition of alpelisib to fulvestrant significantly extended progression-free survival in PIK3CA-mutant, hormone receptor-positive (HR+) advanced/metastatic breast cancer in the phase III SOLAR-1 study. The combination of alpelisib and letrozole also had promising activity in phase I studies of HR+ advanced/metastatic breast cancer. NEO-ORB aimed to determine if addition of alpelisib to letrozole could increase response rates in the neoadjuvant setting. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3160DOI Listing
February 2019

Advances in surgical strategies for prolapse.

Climacteric 2019 Feb;22(1):60-64

a Division of Obstetrics and Gynecology, Department of Experimental and Clinical Medicine , University of Pisa , Pisa , Italy.

Pelvic floor dysfunctions are a complex condition in elderly women; pelvic organ prolapse, urinary or fecal incontinence, constipation, pelvic pain, and sexual dysfunction are common problems. The goal of surgical treatment is functional reconstruction with symptom management and repair of anatomic defects. The recent advancements in surgical treatment of pelvic floor dysfunction allow several good options for choosing the best surgery for each patient. Read More

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http://dx.doi.org/10.1080/13697137.2018.1543266DOI Listing
February 2019
2 Reads

Exploring the effect of antenatal depression treatment on children's epigenetic profiles: findings from a pilot randomized controlled trial.

Clin Epigenetics 2019 Feb 4;11(1):18. Epub 2019 Feb 4.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, location AMC, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands.

Background: Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal and observational human studies. Therefore, evidence from experimental human studies is needed. Read More

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http://dx.doi.org/10.1186/s13148-019-0616-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360775PMC
February 2019

MicroRNA regulation of TRAIL mediated signaling in different cancers: Control of micro steering wheels during the journey from bench-top to the bedside.

Semin Cancer Biol 2019 Feb 1. Epub 2019 Feb 1.

Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, 36604, USA. Electronic address:

Large-scale sequencing methodologies have helped us identify numerous genomic alterations and we have started to scratch the surface of many new targets for treatment of cancer and the associated predictive biomarkers. TRAIL (TNF-related apoptosis-inducing ligand) is a highly appreciated anti-cancer molecule because of its ability to selectively target cancer cells. However, confluence of information suggests that cancer cells develop resistance against TRAIL-based therapeutics. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.01.007DOI Listing
February 2019
1 Read

HMGB1 and markers of oxidative stress in human cord blood.

Pediatr Int 2019 Feb 4. Epub 2019 Feb 4.

Neonatal Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Italy.

Background: Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of pregnancy to the birth of the infant. The aim of the present work was to evaluate serum cord blood concentrations of derivated reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and HMGB1 to study perinatal oxidative status of neonates and correlation with mode of delivery, as well as the influence of labour.

Methods: The study subjects were 214 neonates delivered at University Hospital "G. Read More

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http://dx.doi.org/10.1111/ped.13795DOI Listing
February 2019
2 Reads

Do barbed sutures with different surface textures have different effects on adhesion formation and histological features? An experimental blinded study in an animal model.

Adv Clin Exp Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Acıbadem University, Altunizade Hospital, Istanbul, Turkey.

Background: The obstetrics and gynecology literature has expanded in recent years to include clinical trials assessing the use of barbed sutures. The difficulty of intracorporeal suturing continues to be a barrier to a wider use of laparoscopy. Although the use of barbed sutures has been shown to ease the process of laparoscopic suturing considerably, concerns have been raised regarding a potentially increased risk of adhesions or inflammation as a result of their use. Read More

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http://dx.doi.org/10.17219/acem/92172DOI Listing
January 2019
1 Read

Potential of osteopontin in the management of epithelial ovarian cancer.

Radiol Oncol 2019 Jan 31. Epub 2019 Jan 31.

Department of Gynaecology, Division of Gynaecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Background Osteopontin (sOPN) is a promising blood tumour marker for detecting epithelial ovarian cancer (EOC). However, other clinical uses of sOPN as a tumour marker in EOC are still lacking. Since sOPN concentrations in serum are not associated with those in ascites, we compared clinical value of sOPN concentrations in the two body fluids. Read More

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http://dx.doi.org/10.2478/raon-2019-0003DOI Listing
January 2019
2 Reads

The One Step approach for diagnosing gestational diabetes is associated with better perinatal outcomes than using the Two Step approach: Evidence of Randomized Clinical Trials.

Am J Obstet Gynecol 2019 Jan 31. Epub 2019 Jan 31.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Einstein HealthCare Network, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.ajog.2019.01.231DOI Listing
January 2019
1 Read
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Simultaneous Measurement of 92 Serum Protein Biomarkers for the Development of a Multi-Protein Classifier for Ovarian Cancer Detection.

Cancer Prev Res (Phila) 2019 Feb 1. Epub 2019 Feb 1.

Division of Biostatistics, School of Public Health, University of Minnesota.

The best known ovarian cancer biomarker, CA125, is neither adequately sensitive nor specific for screening the general population. By using a combination of proteins for screening, it may be possible to increase the sensitivity and specificity over CA125 alone. In this study, we used Proseek® Multiplex Oncology II plates to simultaneously measure the expression of 92 cancer-related proteins in serum using proximity extension assays. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0221DOI Listing
February 2019

Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain.

Int J Mol Sci 2019 Jan 30;20(3). Epub 2019 Jan 30.

Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin 20-090, Poland.

Among the new adipokines, secreted frizzled-related protein 5 (SFRP5) is considered to prevent obesity and insulin resistance. The umbilical cord SFRP5 levels have not yet been investigated. The main aim of the study was to investigate whether the umbilical cord SFRP5 concentrations are altered in term neonates born to mothers with excessive gestational weight gain (EGWG). Read More

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http://dx.doi.org/10.3390/ijms20030595DOI Listing
January 2019

Clinical Effect of Low Molecular Weight Heparin Sodium Combined with Magnesium Sulfate in the Treatment of Patients with Severe Preeclampsia.

J Coll Physicians Surg Pak 2019 Feb;29(2):119-122

Department of Obstetrics and Gynecology, Yulin First Hospital, Shaanxi Province, 718000, China.

Objective: To investigate the effect of low molecular weight heparin sodium combined with magnesium sulfate in the treatment of patients with severe preeclampsia.

Study Design: An experimental study.

Place And Duration Of Study: The Department of Obstetrics and Gynecology, The Affiliated Hospital, North China University of Science and Technology, from April 2016 to July 2017. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.02.119DOI Listing
February 2019

The incidence of and risk factors for complications when removing a single uterine fibroid during cesarean section: a retrospective study with use of two comparison groups.

J Matern Fetal Neonatal Med 2019 Jan 30:1-8. Epub 2019 Jan 30.

e Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University) , Moscow State University, Inststitutskii per 9 , Dolgoprudny, Moscow region , Russia.

Purpose: To determine the incidence of and risk factors for perioperative complications in women with a single uterine fibroid, who had a cesarean myomectomy (CM).

Methods: This was a retrospective study of women who had a CM between 2015-2016. They were compared versus women who had a cesarean section (CS) alone and nonpregnant women who had a laparotomic myomectomy (LM). Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1570124DOI Listing
January 2019
2 Reads

The Emerging Role of Bone Markers in Diagnosis and Risk Stratification of Patients With Coronary Artery Disease.

Angiology 2019 Jan 29:3319718822625. Epub 2019 Jan 29.

6 First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Molecules that govern bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), have been isolated from other tissues, including blood vessels. Atherosclerosis and coronary artery disease (CAD) are leading causes of mortality worldwide. Despite novel biochemical and imaging techniques, early detection of CAD is still unsatisfactory. Read More

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http://dx.doi.org/10.1177/0003319718822625DOI Listing
January 2019

Metabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment.

Fertil Steril 2019 Feb;111(2):212-218

Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, Connecticut. Electronic address:

Current strategies for embryo assessment in the assisted reproductive technology laboratories rely primarily on morphologic parameters that have limited accuracy for determining embryo viability. Even with the addition of invasive diagnostic interventions such as preimplantation genetic testing for aneuploidy alone or in combination with mitochondrial DNA copy number assessment, at least one third of embryos fail to implant. Therefore, at a time when the clinical benefits of single ET are widely accepted, improving viability assessment of embryos is ever more important. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183230
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http://dx.doi.org/10.1016/j.fertnstert.2018.12.014DOI Listing
February 2019
7 Reads

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status.

J Ovarian Res 2019 Jan 28;12(1). Epub 2019 Jan 28.

Department of Health of Woman and Child, Gynecologic Oncology Unit, Catholic University of Sacred Heart, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-strand DNA breaks through homologous recombination, lead to increased cancer predisposition. Read More

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http://dx.doi.org/10.1186/s13048-019-0484-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348631PMC
January 2019

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.

Gynecol Oncol 2019 Jan 24. Epub 2019 Jan 24.

Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States of America; Department of Oncology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Objective: Poly(ADP-ribose) polymerase (PARP) inhibitors have shown substantial activity in homologous recombination- (HR-) deficient ovarian cancer and are undergoing testing in other HR-deficient tumors. For reasons that are incompletely understood, not all patients with HR-deficient cancers respond to these agents. Preclinical studies have demonstrated that changes in alternative DNA repair pathways affect PARP inhibitor (PARPi) sensitivity in ovarian cancer models. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.015DOI Listing
January 2019
1 Read

Estrogen metabolism pathways in preeclampsia and normal pregnancy.

Steroids 2019 Jan 25;144:8-14. Epub 2019 Jan 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, United States.

Background: Experimental studies suggest that shallow uterine cytotrophoblastic invasion in preeclampsia may be associated with alterations in estrogen metabolism. The objective of this study was to examine the association of parent estrogens and their metabolites between preeclamptics and normotensive controls at three time points during pregnancy. Methods Parent estrogens and their metabolites were measured in urine by high-performance liquid chromatography-tandem mass spectrometry in 66 singleton preeclampsia cases and 137 matched controls. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.01.005DOI Listing
January 2019
3 Reads

Intrauterine administration of autologous peripheral blood mononuclear cells in patients with recurrent implantation failure: A systematic review and meta-analysis.

J Reprod Immunol 2019 Feb 15;131:50-56. Epub 2019 Jan 15.

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:

Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC) has been proposed to improve implantation rates in women with recurrent implantation failure (RIF). The objective of this study was to evaluate whether intrauterine administration of PBMC improves clinical pregnancy and live birth in couples with RIF. Various databases were searched including Medline, Embase, Scopus, Web of Science and Cochrane Central Register of Controlled Trials up to April 2018. Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.001DOI Listing
February 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019
5 Reads
10.742 Impact Factor

Sexual Function Under Adequate Estrogen Therapy in Women After Oophorectomy Versus Natural Menopause.

J Womens Health (Larchmt) 2019 Jan 25. Epub 2019 Jan 25.

1 Laboratory of Clinical and Experimental Research in Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro-Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.

Background: There is scarce evidence regarding endogenous postmenopausal ovarian testosterone (T) production and estrogen replacement roles in different sexual domains. This study aimed to determine whether lower endogenous T in oophorectomized women that were estradiol (E2)-treated influenced global or specific domains of sexual function. Depressive and cognitive symptoms were evaluated to exclude potential confounders. Read More

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http://dx.doi.org/10.1089/jwh.2017.6905DOI Listing
January 2019
7 Reads

Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer.

Ann Surg Oncol 2019 Jan 24. Epub 2019 Jan 24.

Division of Surgical Oncology, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: Breast cancer is the most common malignancy diagnosed in women of childbearing age. A breast cancer diagnosis in this young patient population can be uniquely complex to navigate when considering the potential impact of fertility loss associated with specific gonadotoxic therapies. Another unique challenge for young breast cancer patients is pregnancy-associated breast cancer (PABC), which occurs in approximately 1 of every 3000 pregnancies. Read More

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http://dx.doi.org/10.1245/s10434-019-07156-7DOI Listing
January 2019
1 Read

Microfibrous scaffolds from poly(l-lactide-co-ε-caprolactone) blended with xeno-free collagen/hyaluronic acid for improvement of vascularization in tissue engineering applications.

Mater Sci Eng C Mater Biol Appl 2019 Apr 6;97:31-44. Epub 2018 Dec 6.

BIOMATEN, METU Center of Excellence in Biomaterials and Tissue Engineering, Ankara, Turkey; Department of Biological Sciences, Middle East Technical University (METU), Ankara, Turkey.

Success of 3D tissue substitutes in clinical applications depends on the presence of vascular networks in their structure. Accordingly, research in tissue engineering is focused on the stimulation of angiogenesis or generation of a vascular network in the scaffolds prior to implantation. A novel, xeno-free, collagen/hyaluronic acid-based poly(l-lactide-co-ε-caprolactone) (PLC/COL/HA) (20/9. Read More

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http://dx.doi.org/10.1016/j.msec.2018.12.011DOI Listing

Oral investigational drugs currently in phase I or phase II for the amelioration of menopausal symptoms.

Expert Opin Investig Drugs 2019 Mar 1;28(3):235-247. Epub 2019 Feb 1.

b Department of Obstetrics and Gynecology , University of Liège , Liège , Belgium.

Introduction: Menopausal symptoms have a substantial effect on the quality of life of many women; hence, investigations for the amelioration of menopausal symptoms continue to be necessary. The two main approaches to the amelioration of symptoms are hormone therapy (HT) and non-hormonal therapy. Areas covered: This review provides a background for understanding the types of menopausal symptoms and their underlying physiology. Read More

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http://dx.doi.org/10.1080/13543784.2019.1572114DOI Listing
March 2019
1 Read

Interplay of long non-coding RNAs and TGF/SMAD signaling in different cancers.

Cell Mol Biol (Noisy-le-grand) 2018 Dec 31;64(15):1-6. Epub 2018 Dec 31.

Laboratoire d'immunologie cellulaire et moleculaire, Centre hospitalier de l'universite de Montreal, Tour Viger, 900 rue Saint-Denis, Montreal, Montreal H2X0A9, Quebec, Canada.

Based on the exciting insights gleaned from decades of ground-breaking research, it has become evident that deregulated signaling pathways play instrumental role in cancer development and progression. Interestingly discovery of non-coding RNAs has revolutionized our understanding related to transcription, post-transcription and translation. Modern era has witnessed landmark discoveries in the field of molecular cancer and non-coding RNA biology has undergone tremendous broadening. Read More

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December 2018
3 Reads

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy.

Int J Mol Sci 2019 Jan 19;20(2). Epub 2019 Jan 19.

Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, Italy.

Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. Read More

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http://dx.doi.org/10.3390/ijms20020428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359245PMC
January 2019
1 Read

Gender differences in how physicians access and process information.

Gynecol Oncol Rep 2019 Feb 2;27:50-53. Epub 2019 Jan 2.

Lauder School of Government, Diplomacy and Strategy, IDC, Israel.

There is an absence of information on how physicians make surgical decisions, and on the effect of gender on the processing of information. A novel web based decision-matrix software was designed to trace experimentally the process of decision making in medical situations. The scenarios included a crisis and non-crisis simulation for endometrial cancer surgery. Read More

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http://dx.doi.org/10.1016/j.gore.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325067PMC
February 2019
2 Reads

A Comprehensive RNA Expression Signature for Cervical Squamous Cell Carcinoma Prognosis.

Front Genet 2018 4;9:696. Epub 2019 Jan 4.

The First Department of Operation, Hunan Provincial People's Hospital, Changsha, China.

Clinicopathological characteristics alone are not enough to predict the survival of patients with cervical squamous cell carcinoma (CESC) due to clinical heterogeneity. In recent years, many genes and non-coding RNAs have been shown to be oncogenes or tumor-suppressors in CESC cells. This study aimed to develop a comprehensive transcriptomic signature for CESC patient prognosis. Read More

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http://dx.doi.org/10.3389/fgene.2018.00696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328499PMC
January 2019
1 Read

CGRP Is Critical for Hot Flushes in Ovariectomized Mice.

Front Pharmacol 2018 4;9:1452. Epub 2019 Jan 4.

Division of Childrens and Womens Health, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Hot flushes are common and troublesome symptoms of menopause. The neuropeptide calcitonin gene-related peptide (CGRP) is increased in plasma during hot flushes but it has not been clear if CGRP is causally involved in the mechanism underpinning the flushes. Here, we examined the effect of interventions with CGRP in a mouse model of hot flushes based on flush-like temperature increases triggered by forced physical activity in ovariectomized mice. Read More

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http://dx.doi.org/10.3389/fphar.2018.01452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328451PMC
January 2019
2 Reads

Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists.

Crit Rev Oncol Hematol 2019 Jan 2;133:92-98. Epub 2018 Nov 2.

Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy.

Mature cystic teratomas of the ovary have an incidence of 1.2-14.2 cases per 100. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.10.005DOI Listing
January 2019
2 Reads

Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue.

Lipids Health Dis 2019 Jan 18;18(1):19. Epub 2019 Jan 18.

Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.

Background: Prenatal dexamethasone treatment has been shown to enhance the susceptibility of offspring to postnatal high-fat (HF) diet-induced programmed obesity. We investigated the metabolic phenotypes, nutrient-sensing signal and circadian-clock genes in adipose tissue that are programmed by prenatal dexamethasone exposure and postnatal HF diet.

Methods: Male offspring of Sprague-Dawley rats were divided into four experimental groups: normal diet, prenatal dexamethasone exposure, postnatal HF diet, and prenatal dexamethasone plus postnatal HF diet. Read More

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http://dx.doi.org/10.1186/s12944-019-0963-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339284PMC
January 2019
1 Read
2.219 Impact Factor

'Absent' pulmonary valve with intact ventricular septum mimicking tricuspid valve atresia: Prenatal diagnosis and postnatal course.

J Obstet Gynaecol Res 2019 Jan 17. Epub 2019 Jan 17.

Pediatric Cardiology, Tuscany Region-National Centre for Research Foundation, Ospedale del Cuore, Massa, Italy.

Absent pulmonary valve syndrome is a rare congenital heart disease characterized by absent or rudimentary pulmonary valve leaflets and hypoplastic pulmonary annulus. The most common variant, associated with tetralogy of Fallot, implies dilatation of pulmonary branches and usually absent ductus arteriosus. Rarely, absent pulmonary valve occurs with intact ventricular septum: pulmonary branches are normally sized or mildly dilated and ductus arteriosus is usually patent. Read More

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http://dx.doi.org/10.1111/jog.13878DOI Listing
January 2019
9 Reads