346 results match your criteria Clinical and Experimental Gastroenterology [Journal]


Exocrine pancreatic insufficiency: prevalence, diagnosis, and management.

Clin Exp Gastroenterol 2019 21;12:129-139. Epub 2019 Mar 21.

Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy,

Exocrine pancreatic insufficiency (EPI) is a condition caused by reduced or inappropriate secretion or activity of pancreatic juice and its digestive enzymes, pancreatic lipase in particular. EPI can result in clinical manifestation and biochemical alterations causing reduced quality of life and life-threating complications. EPI is common in pancreatic disorders, where it should be suspected and actively investigated, and in many extrapancreatic conditions. Read More

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http://dx.doi.org/10.2147/CEG.S168266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432881PMC
March 2019
1 Read

Iatrogenic bile duct injury: impact and management challenges.

Clin Exp Gastroenterol 2019 6;12:121-128. Epub 2019 Mar 6.

Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy,

Iatrogenic bile duct injuries (BDIs) after laparoscopic cholecystectomy, being one of the most common performed surgical procedures, remain a substantial problem in gastrointestinal surgery with a significant impact on patient's quality of life. The primary aim of this review was to discuss the classification of BDIs, the proposed methods to prevent biliary lesions, the associated risk factors, and the management challenges depending on the timing of recognition of the injury, its extension, the patient's clinical condition, and the availability of experienced hepatobiliary surgeons. Early recognition of BDI is of paramount importance and limiting the diagnosis delay is crucial for an optimal postoperative outcome. Read More

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https://www.dovepress.com/iatrogenic-bile-duct-injury-impact
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http://dx.doi.org/10.2147/CEG.S169492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408920PMC
March 2019
4 Reads

Management of microscopic colitis: challenges and solutions.

Clin Exp Gastroenterol 2019 27;12:111-120. Epub 2019 Feb 27.

Department of Gastroenterology, University of Massachusetts Medical School, Worcester, MA, USA,

Microscopic colitis (MC) is a chronic inflammatory bowel disease characterized by nonbloody diarrhea in the setting of normal appearing colonic mucosa. MC has two main subtypes based on histopathologic features, collagenous colitis and lymphocytic colitis. Management of both subtypes is the same, with treatment goal of reducing the number of bowel movements and improving consistency. Read More

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http://dx.doi.org/10.2147/CEG.S165047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398419PMC
February 2019
2 Reads

Propofol sedation in colonoscopy: from satisfied patients to improved quality indicators.

Clin Exp Gastroenterol 2019 26;12:105-110. Epub 2019 Feb 26.

Gastroenterology and Hepatology Department, Hillel Yaffe Medical Center, affiliated to the Ruth and Rappaport Faculty of Medicine, Haifa, Israel,

Background: Propofol-mediated sedation is safe and clearly associated with increased patient satisfaction. However, whether it results in a favorable effect on colonoscopy outcomes and performance compared to standard sedation with benzodiazepines/opiates remains unclear.

Objectives: To determine the effect of propofol-mediated sedation on colonoscopy-quality measures compared to traditional sedation. Read More

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http://dx.doi.org/10.2147/CEG.S186393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396664PMC
February 2019
3 Reads

Development and psychometric evaluation of the Diabetic Gastroparesis Symptom Severity Diary.

Clin Exp Gastroenterol 2019 22;12:93-103. Epub 2019 Feb 22.

Patient-Centered Outcomes Research, Global Evidence and Value Development, Allergan plc, Madison, NJ, USA,

Background: Diabetic gastroparesis (DG) is defined as delayed gastric emptying with associated gastrointestinal symptoms, without mechanical obstruction. Patient-reported symptoms are critical for diagnosis and evaluation of treatment benefit in DG. The Diabetic Gastroparesis Symptom Severity Diary (DGSSD), a new patient-reported outcome measure, was developed for use in clinical trials to support product approval and labeling claims for DG treatments. Read More

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http://dx.doi.org/10.2147/CEG.S184016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390855PMC
February 2019

Benign biliary strictures: prevalence, impact, and management strategies.

Clin Exp Gastroenterol 2019 18;12:83-92. Epub 2019 Feb 18.

Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, Murdoch, Perth, WA 6150, Australia,

Benign biliary strictures (BBSs) may form from chronic inflammatory pancreaticobiliary pathologies, postoperative bile-duct injury, or at biliary anastomoses following liver transplantation. Treatment aims to relieve symptoms of biliary obstruction, maintain long-term drainage, and preserve liver function. Endoscopic therapy, including stricture dilatation and stenting, is effective in most cases and the first-line treatment of BBS. Read More

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http://dx.doi.org/10.2147/CEG.S165016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385742PMC
February 2019
1 Read

Beneficial effects of CNCM I-745 on clinical disorders associated with intestinal barrier disruption.

Clin Exp Gastroenterol 2019 11;12:67-82. Epub 2019 Feb 11.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc scientifique et technologique de Luminy, Marseille, France.

Intestinal barrier defects lead to "leaky gut syndrome", defined as an increase in intestinal permeability that allows the passage of luminal content into intestinal tissue and the bloodstream. Such a compromised intestinal barrier is the main factor underlying the pathogenesis of inflammatory bowel disease, but also commonly occurs in various systemic diseases such as viral infections and metabolic syndrome. The non-pathogenic yeast CNCM I-745 has demonstrated its effectiveness as a probiotic in the prevention and treatment of antibiotic-associated, infectious and functional diarrhea. Read More

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https://www.dovepress.com/beneficial-effects-of-saccharomyce
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http://dx.doi.org/10.2147/CEG.S181590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375115PMC
February 2019
3 Reads

Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma.

Clin Exp Gastroenterol 2019 1;12:51-66. Epub 2019 Feb 1.

Department of Tropical Medicine, Faculty of Medicine, Minia University, Minia, Egypt.

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. It has been widely established that the early detection of HCC enables more treatment options with improvements in prognosis and survival.

Objectives: The aim of this study was to assess the diagnostic accuracy of both circulating miR-215 and squamous cell carcinoma antigen-IgM (SCCA-IgM) as serum biomarkers for HCC by examining their diagnostic sensitivity, specificity, accuracy, and predictive values in hepatitis C virus (HCV)-induced HCC patients. Read More

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http://dx.doi.org/10.2147/CEG.S179832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362918PMC
February 2019
1 Read

Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.

Clin Exp Gastroenterol 2019 31;12:37-49. Epub 2019 Jan 31.

Department of Pediatrics, Oslo University Hospital, Ullevål, Oslo, Norway.

Purpose: Imbalance in the microbiota, dysbiosis, has been identified in inflammatory bowel disease (IBD). We explored the fecal microbiota in pediatric patients with treatment-naïve IBD, non-IBD patients with gastrointestinal symptoms and healthy children, its relation to IBD subgroups, and treatment outcomes.

Patients And Methods: Fecal samples were collected from 235 children below 18 years of age. Read More

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http://dx.doi.org/10.2147/CEG.S186235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362922PMC
January 2019
1 Read

Profile of plecanatide in the treatment of chronic idiopathic constipation: design, development, and place in therapy.

Clin Exp Gastroenterol 2019 22;12:31-36. Epub 2019 Jan 22.

Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA,

Constipation is a multifactorial disorder that can cause significant psychological distress to patients and economic burden on the health care system. Many patients are not satisfied with their current established treatment, highlighting the need for new and improved therapeutic options. Guanylate cyclase-C (GC-C)/cyclic guanosine monophosphate agonists have emerged as a safe and efficacious class of drugs for the treatment of chronic idiopathic constipation (CIC). Read More

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http://dx.doi.org/10.2147/CEG.S145668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348976PMC
January 2019
1 Read

Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial.

Clin Exp Gastroenterol 2019 15;12:21-30. Epub 2019 Jan 15.

Biomedicine Research Group, Nnamdi Azikiwe University, Awka, Nigeria,

Background: To our knowledge, there is no prior randomized study on the utility of Syferol-IHP (blend of virgin coconut oil and oil) when coadministered with a triple therapy schedule.

Aim: This study determined the efficacy and safety of Syferol-IHP as adjunct to conventional triple therapy for the treatment of peptic ulcer disease (PUD).

Methods: A pilot double-blind randomized trial was conducted in patients with confirmed diagnosis (endoscopy-guided biopsy) of PUD. Read More

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https://www.dovepress.com/efficacy-and-safety-of-syferol-ihp
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http://dx.doi.org/10.2147/CEG.S178179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338118PMC
January 2019
7 Reads

A pilot study of fecal bile acid and microbiota profiles in inflammatory bowel disease and primary sclerosing cholangitis.

Clin Exp Gastroenterol 2019 10;12:9-19. Epub 2019 Jan 10.

Inflammatory Bowel Program, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, USA,

Introduction: Inflammatory bowel disease (IBD) is thought to arise from an abnormal immune response to the gut microbiota. IBD is associated with altered intestinal microbial community structure and functionality, which may contribute to inflammation and complications such as colon cancer and liver disease. Primary sclerosing cholangitis (PSC) is associated with IBD and markedly increases the risk of colon cancer. Read More

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https://www.dovepress.com/a-pilot-study-of-fecal-bile-acid-a
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http://dx.doi.org/10.2147/CEG.S186097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330977PMC
January 2019
11 Reads

Mesenteric panniculitis: comparison of computed tomography findings in patients with and without malignancy.

Clin Exp Gastroenterol 2019 27;12:1-8. Epub 2018 Dec 27.

Department of Radiology, Jordan University of Science and Technology, King Abdullah University Hospital, Irbid, Jordan,

Purpose: The aim was to compare computed tomography (CT) findings between patients with mesenteric panniculitis (MP) with and without known malignancy.

Patients And Methods: We retrospectively analyzed 116 consecutive patients who were diagnosed with MP on the basis of CT findings and categorized them according to the absence (Group 1: 73 patients) or presence (Group 2: 43 patients) of malignancy. Patient age and sex, diameter, size, mass effect, location, and fat density of the MP mass, presence of a pseudocapsule and/or halo sign, and lymph node status were compared between the two groups. Read More

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http://dx.doi.org/10.2147/CEG.S182513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311320PMC
December 2018
1 Read

Biological therapy for the treatment of prepouch ileitis: a retrospective observational study from three centers.

Clin Exp Gastroenterol 2018 11;11:461-465. Epub 2018 Dec 11.

Inflammatory Bowel Disease Department, St Mark's Hospital, Harrow, UK,

Aim: Prepouch ileitis (PPI) is inflammation of the ileum proximal to an ileoanal pouch, usually associated with pouchitis. The treatment of PPI as a specific entity has been poorly studied, but it is generally treated concurrently with pouchitis. This to our knowledge is the largest study to explore the efficacy of biologics for the specific treatment of PPI. Read More

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https://www.dovepress.com/biological-therapy-for-the-treatme
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http://dx.doi.org/10.2147/CEG.S179418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296384PMC
December 2018
12 Reads

Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives.

Authors:
Udo Rudloff

Clin Exp Gastroenterol 2018 3;11:447-459. Epub 2018 Dec 3.

Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA,

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a recently described, rare gastric polyposis syndrome. It is characterized by extensive involvement of the fundus and body of the stomach with fundic gland polyps sparing the antrum and lesser curvature, an autosomal dominant inheritance pattern with incomplete penetrance, and a significant predisposition for the development of gastric adenocarcinoma. Due to the recent discovery of APC promotor IB mutations (c. Read More

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https://www.dovepress.com/gastric-adenocarcinoma-and-proxima
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http://dx.doi.org/10.2147/CEG.S163227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284852PMC
December 2018
37 Reads

Incidence of catheter-related complications among Japanese patients with central venous catheters as well as patients with short bowel syndrome.

Clin Exp Gastroenterol 2018 28;11:439-445. Epub 2018 Nov 28.

Shire, Lexington, MA, USA,

Purpose: Short bowel syndrome (SBS) is a serious rare disorder that is usually managed with parenteral nutrition. Central venous catheter (CVC)-related complications are known to occur, but their incidence rates (IRs) in Japan are unknown. The aim of this study was to estimate the incidence of complications in Japanese patients with CVCs, including patients with SBS using CVCs. Read More

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http://dx.doi.org/10.2147/CEG.S172430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276634PMC
November 2018
3 Reads

Real-world comparison of the effectiveness and safety of different bowel preparation agents.

Clin Exp Gastroenterol 2018 16;11:289-299. Epub 2018 Aug 16.

Ferring Pharmaceuticals Inc., Parsippany, NJ, USA,

Background And Aims: Proper bowel cleansing is necessary prior to colonoscopy, but poor tolerability to bowel preparation agents may increase the odds of poor cleansing and incomplete screenings. The aim of this study was to evaluate the real-world effectiveness and safety of bowel preparation agents.

Methods: Claims data were extracted for individuals who had a screening colonoscopy from July 1, 2012, to June 30, 2015, were ≥18 years of age, and who could be observed ≥6 months before and ≥3 months after the screening. Read More

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http://dx.doi.org/10.2147/CEG.S171861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280884PMC
August 2018
3 Reads

Serum human endothelial cell-specific molecule-1 (endocan) and vascular endothelial growth factor in cirrhotic HCV patients with hepatocellular carcinoma as predictors of mortality.

Clin Exp Gastroenterol 2018 23;11:431-438. Epub 2018 Nov 23.

Department of Clinical and Chemical Pathology, Al Tahrir Hospital, Giza, Egypt.

Objectives: The aim of this study was to assess serum levels of endocan & VEGF in patients with hepatitis C virus-related HCC and their diagnostic and predictive value of mortality.

Methods: A total of 195 patients with CHC were subdivided into the following two groups: 105 HCV cirrhotic patients with HCC and 90 HCV cirrhotic patients without HCC. Sixty apparently healthy subjects served as the control group. Read More

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http://dx.doi.org/10.2147/CEG.S171339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260127PMC
November 2018
2 Reads

Inflammatory bowel disease epidemiology in São Paulo State, Brazil.

Clin Exp Gastroenterol 2018 30;11:423-429. Epub 2018 Oct 30.

Department of Surgery, Botucatu Medical School at Sao Paulo State University (UNESP), Botucatu, Brazil.

Purpose: This study aimed to estimate the incidence and prevalence of inflammatory bowel disease (IBD) in São Paulo, Brazil, for 2012-2015.

Patients And Methods: This observational, descriptive, and cross-sectional study included 22,638 IBD patients out of 43,046,555 inhabitants, who had initiated their treatment through the Governmental Program of the Brazilian Unified National Health System between the years of 2012 and 2015. The onset of the disease (used to determine incidence) was established as the date of the patient's initial registration in the Governmental Program with a diagnosis for Crohn's disease (CD) or ulcerative colitis (UC). Read More

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http://dx.doi.org/10.2147/CEG.S176583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214600PMC
October 2018
10 Reads

A study of the circulating fibroblast growth factor 21 as a novel noninvasive biomarker of hepatic injury in genotype-4 chronic hepatitis C: Egyptian patients and their response to direct-acting antiviral agents.

Clin Exp Gastroenterol 2018 24;11:415-422. Epub 2018 Oct 24.

Clinical Pathology Department, Minia University, El-Minia, Egypt.

Background: Fibroblast growth factor (FGF) 21 was reported to be induced by different injurious agents, including chronic hepatitis C (CHC) virus, affecting the liver. The aims of this study were to evaluate the FGF21 levels in CHC patients before and after the treatment with direct-acting antiviral agents (DAAs) in comparison to that in control subjects and to correlate these levels with insulin resistance (IR), lipid profile, and fibrosis stages.

Patients And Methods: We studied 75 naive CHC patients and 40 age- and gender-matched healthy control subjects. Read More

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https://www.dovepress.com/a-study-of-the-circulating-fibrobl
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http://dx.doi.org/10.2147/CEG.S173484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204854PMC
October 2018
17 Reads

Patients with chronic mesenteric ischemia have an altered sublingual microcirculation.

Clin Exp Gastroenterol 2018 18;11:405-414. Epub 2018 Oct 18.

Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Background: Little is known about the microcirculatory alterations in patients with chronic mesenteric ischemia (CMI). We hypothesized that patients with CMI have an impaired microcirculatory function and show an oral microcirculatory response after caloric challenge compared to healthy controls.

Methods: All patients and controls received the standard workup for CMI. Read More

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https://www.dovepress.com/patients-with-chronic-mesenteric-i
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http://dx.doi.org/10.2147/CEG.S159160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200368PMC
October 2018
16 Reads

Agreement of triage decisions between gastroenterologists and nurses in a hospital endoscopy unit.

Clin Exp Gastroenterol 2018 16;11:399-403. Epub 2018 Oct 16.

Hutt Valley DHB Endoscopy Unit, Hutt Valley DHB, Lower Hutt, Wellington, New Zealand,

Introduction: Efficient and accurate triage of endoscopy referrals is essential. Many of the decisions made are based on national and local triage criteria. Standardizing this approach for nurse use could maintain quality, address clinical risk and significantly improve resource utilization. Read More

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https://www.dovepress.com/agreement-of-triage-decisions-betw
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http://dx.doi.org/10.2147/CEG.S159516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199221PMC
October 2018
19 Reads

An integrated electronic health record-based workflow to improve management of colonoscopy-generated pathology results.

Clin Exp Gastroenterol 2018 8;11:391-397. Epub 2018 Oct 8.

Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA,

Purpose: Managing and communicating colonoscopy-generated pathology results and appropriate follow-up recommendations can be challenging. To improve this process, we developed and implemented a standardized electronic health record-based intervention with built-in decision support.

Methods: Fourteen attending endoscopists performed enough colonoscopies to qualify for the study. Read More

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http://dx.doi.org/10.2147/CEG.S170757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181114PMC
October 2018
2 Reads

Bioavailability of dexlansoprazole delayed-release capsule granules when administered via nasogastric tube or orally via syringe.

Clin Exp Gastroenterol 2018 5;11:381-389. Epub 2018 Oct 5.

Department of Clinical Science, Takeda Development Center Americas, Inc., Deerfield, IL, USA,

Objective: To assess the effect of route of administration on the bioavailability of dexlansoprazole 60 mg delayed-release capsule granules.

Methods: One open-label, Phase I, single-dose, 3-period crossover study was conducted in healthy adults. The bioavailability of Dexilant (dexlansoprazole) after dexlansoprazole capsule granules were mixed with water and administered via 16 French nasogastric tube or orally via syringe was compared to administration of the intact capsule in the fasted state, swallowed with water. Read More

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https://www.dovepress.com/bioavailability-of-dexlansoprazole
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http://dx.doi.org/10.2147/CEG.S138580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177519PMC
October 2018
15 Reads

D-dimer plasmatic levels as a marker for diagnosis and prognosis of hepatocellular carcinoma patients with portal vein thrombosis.

Clin Exp Gastroenterol 2018 3;11:373-380. Epub 2018 Oct 3.

Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy,

Purpose: Portal vein thrombosis (PVT) is one of the severe complications of hepatocellular carcinoma (HCC). PVT deteriorates the liver, and its dysfunction increases the risk of bleeding, influencing the prognosis of patients with liver cirrhosis and HCC. The aim of our study was to investigate whether D-dimer testing could be a sensitive marker for the diagnosis and prognosis of HCC patients with PVT. Read More

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https://www.dovepress.com/d-dimer-plasmatic-levels-as-a-mark
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http://dx.doi.org/10.2147/CEG.S172663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174900PMC
October 2018
17 Reads

Focus on the use of antidepressants to treat pediatric functional abdominal pain: current perspectives.

Clin Exp Gastroenterol 2018 28;11:365-372. Epub 2018 Sep 28.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital. Boston, MA, USA,

Chronic abdominal pain is frequently encountered in pediatric practice. A large proportion of cases meet Rome criteria for abdominal pain-functional gastrointestinal disorders (AP-FGIDs). These disorders are costly and, in some cases, lead to impairment of daily functioning and overall quality of life. Read More

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https://www.dovepress.com/focus-on-the-use-of-antidepressant
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http://dx.doi.org/10.2147/CEG.S146646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166750PMC
September 2018
16 Reads

Diabetic gastroparesis: current challenges and future prospects.

Clin Exp Gastroenterol 2018 25;11:347-363. Epub 2018 Sep 25.

Division of Gastroenterology, Center for Neurogastroenterology and GI Motility, Texas Tech University Health Sciences Center, El Paso, TX, USA,

Diabetic gastroparesis (DMGP) is a condition of delayed gastric emptying after gastric outlet obstruction has been excluded. Symptoms of nausea, vomiting, early satiety, bloating, and abdominal pain are associated with DMGP. Uncontrolled symptoms can lead to overall poor quality of life and financial burdens on the healthcare system. Read More

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https://www.dovepress.com/diabetic-gastroparesis-current-cha
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http://dx.doi.org/10.2147/CEG.S131650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165730PMC
September 2018
4 Reads

Short-course therapy for diarrhea-predominant irritable bowel syndrome: understanding the mechanism, impact on gut microbiota, and safety and tolerability of rifaximin.

Clin Exp Gastroenterol 2018 24;11:335-345. Epub 2018 Sep 24.

New Mexico VA Health Care System, Division of Gastroenterology and Hepatology, Albuquerque, NM, USA,

Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder characterized by abdominal pain that occurs with defecation or alterations in bowel habits. Further classification is based on the predominant bowel habit: constipation-predominant IBS, diarrhea-predominant IBS (IBS-D), or mixed IBS. The pathogenesis of IBS is unclear and is considered multifactorial in nature. Read More

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http://dx.doi.org/10.2147/CEG.S167031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160288PMC
September 2018
3 Reads

Hemin reduces inflammation associated with TNBS-induced colitis.

Clin Exp Gastroenterol 2018 18;11:325-334. Epub 2018 Sep 18.

iMed.ULisboa, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal,

Purpose: Hemin is a heme-oxygenase inducer, which can confer anti-inflammatory, cytoprotective, and antiapoptotic effects. These properties are beneficial therapeutical effects to inflammatory bowel disease (IBD). IBD is a worldwide health problem characterized by chronic inflammation of intestinal epithelium, which promotes intestinal and extraintestinal symptomatology. Read More

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https://www.dovepress.com/hemin-reduces-inflammation-associa
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http://dx.doi.org/10.2147/CEG.S166197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151101PMC
September 2018
16 Reads

Noradrenaline for reverting hepatorenal syndrome: a prospective, observational, single-center study.

Clin Exp Gastroenterol 2018 18;11:317-324. Epub 2018 Sep 18.

Department of Internal Medicine, Lady Hardinge Medical College, New Delhi, India,

Objective: To evaluate the effectiveness of noradrenaline for the treatment of hepatorenal syndrome (HRS).

Background: HRS represents the development of renal failure in cirrhotic patients. The standard treatment for HRS is terlipressin, which, as opposed to noradrenaline, is more expensive and less accessible in most tertiary care centers. Read More

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http://dx.doi.org/10.2147/CEG.S153858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151092PMC
September 2018
5 Reads

Achalasia and esophageal cancer: risks and links.

Clin Exp Gastroenterol 2018 6;11:309-316. Epub 2018 Sep 6.

Digestive Physiology and Motility Laboratory, Medical Biological Research Institute, Universidad Veracruzana, Veracruz, Mexico,

Esophageal cancer affects more than 4,50,000 persons worldwide, and its incidence has increased in recent years. It is the eighth most common cancer across the globe. The main histologic types are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA), and their associated risk factors are well known. Read More

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http://dx.doi.org/10.2147/CEG.S141642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132237PMC
September 2018
11 Reads

Liver function tests in identifying patients with liver disease.

Clin Exp Gastroenterol 2018 23;11:301-307. Epub 2018 Aug 23.

Department of Gastroenterology and Hepatology, University of Illinois College of Medicine, Peoria, IL, USA.

Background And Aims: Many patients with liver disease come to medical attention once they have advanced cirrhosis or acute decompensation. Most often, patients are screened for liver disease via liver function tests (LFTs). There is very limited published data evaluating laboratory values with biopsy-proven stages of hepatic fibrosis. Read More

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https://www.dovepress.com/liver-function-tests-in-identifyin
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http://dx.doi.org/10.2147/CEG.S160537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112813PMC
August 2018
16 Reads

Location of appendix in pregnancy: does it change?

Clin Exp Gastroenterol 2018 26;11:281-287. Epub 2018 Jul 26.

Surgical Oncology Department, Shaukat Khanum Hospital, Lahore, Pakistan.

Objectives: This study aimed to determine the change in anatomical location of appendix in full-term pregnancy.

Study Design: This was a descriptive cross-sectional study.

Place And Duration Of Study: Liaquat National University Hospital, Karachi, Pakistan, Department of General Surgery, January 01 to July 31, 2010. Read More

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http://dx.doi.org/10.2147/CEG.S154913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065566PMC
July 2018
1 Read

Natural orifice specimen extraction in colorectal surgery: patient selection and perspectives.

Clin Exp Gastroenterol 2018 24;11:265-279. Epub 2018 Jul 24.

Division of Colorectal Surgery, Lankenau Medical Center, Wynnewood, PA, USA,

Over the past 30 years, colorectal surgery has evolved to include minimally invasive surgical techniques. Minimally invasive surgery is associated with reduced postoperative pain, reduced wound complications, earlier return of bowel function, and possibly shorter length of hospital stay. These benefits have been attributed to a reduction in operative trauma compared to open surgery. Read More

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https://www.dovepress.com/natural-orifice-specimen-extractio
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http://dx.doi.org/10.2147/CEG.S135331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063249PMC
July 2018
4 Reads

Refeeding syndrome in the frail elderly population: prevention, diagnosis and management.

Clin Exp Gastroenterol 2018 10;11:255-264. Epub 2018 Jul 10.

Department for Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital and University of Bern, Bern, Switzerland,

Aging is linked to physiological and pathophysiological changes. In this context, elderly patients often are frail, which strongly correlates with negative health outcomes and disability. Elderly patients are often malnourished, which again is an independent risk factor for both frailty and adverse clinical outcomes. Read More

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http://dx.doi.org/10.2147/CEG.S136429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045900PMC
July 2018
5 Reads

Comparing efficacy of lumen-apposing stents to plastic stents in the endoscopic management of mature peripancreatic fluid collections: a single-center experience.

Clin Exp Gastroenterol 2018 27;11:249-254. Epub 2018 Jun 27.

Department of Gastroenterology, UMass Memorial Medical Center, Worcester, MA, USA,

Introduction: Mature peripancreatic fluid collection (MPFC) is a known and often challenging consequence of acute pancreatitis and often requires intervention. The most common method accepted is the "step-up approach," which consists of percutaneous drainage followed, if necessary, by minimally invasive retroperitoneal necrosectomy. Our paper aims to distinguish between plastic stents and lumen-apposing stents in the endoscopic management of MPFC in terms of morbidity, mortality, and haste of fluid collection resolution. Read More

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http://dx.doi.org/10.2147/CEG.S167736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027700PMC
June 2018
8 Reads

Retrospective analysis of a lactose breath test in a gastrointestinal symptomatic population of Northeast Italy: use of (H+2CH) versus H threshold.

Clin Exp Gastroenterol 2018 18;11:243-248. Epub 2018 Jun 18.

Maria Paola Belloni Center for Personalized Medicine, Data Medica Group, Synlab Limited, Padova, Italy.

Background: Lactose malabsorption is normally evaluated by measuring exhaled H produced by intestinal flora, from unabsorbed lactose. However, differing microbiome composition can lead to the production of CH instead of H; hence, some authors challenge the H method sensitivity and favor the evaluation of both intestinal gases.

Aim: To compare different approaches to usage of a lactose breath test for lactose malabsorption diagnosis, after medical evaluation of gastrointestinal symptoms. Read More

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http://dx.doi.org/10.2147/CEG.S163962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011881PMC
June 2018
3 Reads

Assessment and management of patients with intestinal failure: a multidisciplinary approach.

Clin Exp Gastroenterol 2018 12;11:233-241. Epub 2018 Jun 12.

The Lennard Jones Intestinal Failure Unit, St. Mark's Hospital, Harrow, UK.

Intestinal failure (IF) is a condition characterized by the inability to maintain a state of adequate nutrition, or fluid and electrolyte balance due to an anatomical or a physiological disorder of the gastrointestinal system. IF can be an extremely debilitating condition, significantly affecting the quality of life of those affected. The surgical management of patients with acute and chronic IF requires a specialist team who has the expertise in terms of technical challenges and decision-making. Read More

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http://dx.doi.org/10.2147/CEG.S122868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003282PMC
June 2018
30 Reads

Tumor necrosis factor α-induced protein 3 (A20) is dysregulated in pediatric Crohn disease.

Clin Exp Gastroenterol 2018 30;11:217-231. Epub 2018 May 30.

Department of Pediatrics.

Purpose: A significant feature of pediatric inflammatory bowel diseases (IBD), which include Crohn disease (CD), and ulcerative colitis (UC), is failure to suppress inflammation. The inability to regulate inflammation renders a major challenge toward establishing effective treatments in IBD. Nuclear factor kappa-light-chain-enhancer of activated B-cells-induced inflammation is inhibited by A20 through interactions with TAX1BP1 (Tax1-binding protein 1) and A20-binding inhibitor of NF-κβ activation (ABIN)-1 (A20 binding and inhibitor of NF-κβ) and upon phosphorylation by inhibitor of nuclear factor kappa-β kinase subunit beta (IKKβ), which stabilizes it. Read More

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http://dx.doi.org/10.2147/CEG.S148217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985767PMC
May 2018
10 Reads

A model of blood-ammonia homeostasis based on a quantitative analysis of nitrogen metabolism in the multiple organs involved in the production, catabolism, and excretion of ammonia in humans.

Clin Exp Gastroenterol 2018 24;11:193-215. Epub 2018 May 24.

Research Service, Veterans Affairs Medical Center, Minneapolis, MN, USA.

Increased blood ammonia (NH) is an important causative factor in hepatic encephalopathy, and clinical treatment of hepatic encephalopathy is focused on lowering NH. Ammonia is a central element in intraorgan nitrogen (N) transport, and modeling the factors that determine blood-NH concentration is complicated by the need to account for a variety of reactions carried out in multiple organs. This review presents a detailed quantitative analysis of the major factors determining blood-NH homeostasis - the N metabolism of urea, NH, and amino acids by the liver, gastrointestinal system, muscle, kidney, and brain - with the ultimate goal of creating a model that allows for prediction of blood-NH concentration. Read More

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http://dx.doi.org/10.2147/CEG.S160921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973424PMC
May 2018
5 Reads

Elevated lactate level predicts intensive care unit admissions, endoscopies and transfusions in patients with acute gastrointestinal bleeding.

Clin Exp Gastroenterol 2018 23;11:185-192. Epub 2018 May 23.

Division of Gastroenterology, University of Arizona College of Medicine, Tucson, AZ, USA.

Background And Aims: Initial clinical management decision in patients with acute gastrointestinal bleeding (GIB) is often based on identifying high- and low-risk patients. Little is known about the role of lactate measurement in the triage of patients with acute GIB. We intended to assess if lactate on presentation is predictive of need for intervention in patients with acute GIB. Read More

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http://dx.doi.org/10.2147/CEG.S162703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973428PMC
May 2018
2 Reads

Does the Internet promote the unregulated use of fecal microbiota transplantation: a potential public health issue?

Clin Exp Gastroenterol 2018 1;11:179-183. Epub 2018 May 1.

Department of Gastroenterology, St Mark's Hospital, Harrow, UK.

Introduction: The Internet has become an increasingly popular resource for medical information. Fecal microbiota transplantation (FMT) has changed the treatment of with cure rates of 81% following one infusion of FMT, further studies have since validated these findings. The Medicines and Health care Products Regulatory Agency has classified FMT as a medicine and hence should be only utilized in strict clinical settings. Read More

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http://dx.doi.org/10.2147/CEG.S159609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935081PMC
May 2018
2 Reads

Endoscopic comparison of gastroduodenal injury with over-the-counter doses of new fast-dissolving ibuprofen and paracetamol formulations: a randomized, placebo-controlled, 4-way crossover clinical trial.

Clin Exp Gastroenterol 2018 16;11:169-177. Epub 2018 Apr 16.

Global Clinical Development, GlaxoSmithKline, Collegeville, PA, USA.

Background: While gastrointestinal (GI) effects of standard ibuprofen and N-acetyl-p-aminophenol (APAP) have been reported, upper GI injury following treatment with fast-dissolving (FD) formulations of these analgesics has not been investigated. We evaluated upper GI effects of over-the-counter doses of 2 FD ibuprofen products and 1 FD-APAP product.

Methods: In a randomized, placebo-controlled, endoscopist-blinded, 4-way crossover study, 28 healthy subjects received FD ibuprofen 2×200 mg liquid capsules 3 times daily (TID), ibuprofen 2×200 mg tablets TID, FD-APAP 2×500 mg tablets 4 times daily (QID), and placebo 2×500 mg tablets QID for 7 days. Read More

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https://www.dovepress.com/endoscopic-comparison-of-gastroduo
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http://dx.doi.org/10.2147/CEG.S153231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907787PMC
April 2018
15 Reads

Complete esophageal obstruction following endoscopic variceal ligation: a case report and literature review.

Clin Exp Gastroenterol 2018 10;11:165-168. Epub 2018 Apr 10.

Department of Gastroenterology, Hawkes Bay Hospital, Hastings, New Zealand.

Endoscopic variceal ligation (EVL) is an important treatment modality in managing complications of portal hypertension. Since its advent 30 years ago, the procedural complications have decreased significantly, especially when compared with variceal sclerotherapy. With the current widespread use of EVL, rare complications are now becoming increasingly recognized. Read More

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http://dx.doi.org/10.2147/CEG.S161772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901155PMC
April 2018
6 Reads

Colonic transit time and pressure based on Bernoulli's principle.

Authors:
Yoshiharu Uno

Clin Exp Gastroenterol 2018 5;11:153-163. Epub 2018 Apr 5.

Office Uno Column, Yota, Onoe-Cho, Kakogawa, Japan.

Purpose: Variations in the caliber of human large intestinal tract causes changes in pressure and the velocity of its contents, depending on flow volume, gravity, and density, which are all variables of Bernoulli's principle. Therefore, it was hypothesized that constipation and diarrhea can occur due to changes in the colonic transit time (CTT), according to Bernoulli's principle. In addition, it was hypothesized that high amplitude peristaltic contractions (HAPC), which are considered to be involved in defecation in healthy subjects, occur because of cecum pressure based on Bernoulli's principle. Read More

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http://dx.doi.org/10.2147/CEG.S153676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894719PMC
April 2018
5 Reads

Systemic inflammatory response syndrome and model for end-stage liver disease score accurately predict the in-hospital mortality of black African patients with decompensated cirrhosis at initial hospitalization: a retrospective cohort study.

Clin Exp Gastroenterol 2018 9;11:143-152. Epub 2018 Apr 9.

Medicine and Hepatogastroenterology Unit, Centre Hospitalier et Universitaire de Yopougon, Abidjan, Côte d'Ivoire.

Background: Systemic inflammatory response syndrome (SIRS) and model for end-stage liver disease (MELD) predict short-term mortality in patients with cirrhosis. Prediction of mortality at initial hospitalization is unknown in black African patients with decompensated cirrhosis.

Aim: This study aimed to look at the role of MELD score and SIRS as the predictors of morbidity and mortality at initial hospitalization. Read More

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http://dx.doi.org/10.2147/CEG.S140655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898600PMC
April 2018
15 Reads

Validation of a risk prediction model for Barrett's esophagus in an Australian population.

Clin Exp Gastroenterol 2018 28;11:135-142. Epub 2018 Mar 28.

School of Nursing and Midwifery, Division of Health Sciences, University of South Australia, Adelaide, SA, Australia.

Background: Esophageal adenocarcinoma is a disease that has a high mortality rate, the only known precursor being Barrett's esophagus (BE). While screening for BE is not cost-effective at the population level, targeted screening might be beneficial. We have developed a risk prediction model to identify people with BE, and here we present the external validation of this model. Read More

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http://dx.doi.org/10.2147/CEG.S158627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878665PMC
March 2018
17 Reads

Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions.

Clin Exp Gastroenterol 2018 21;11:119-134. Epub 2018 Mar 21.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

A significant percentage of patients with gastroesophageal reflux disease (GERD) will not respond to proton pump inhibitor (PPI) therapy. The causes of PPI-refractory GERD are numerous and diverse, and include adherence, persistent acid, functional disorders, nonacid reflux, and PPI bioavailability. The evaluation should start with a symptom assessment and may progress to imaging, endoscopy, and monitoring of esophageal pH, impedance, and bilirubin. Read More

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http://dx.doi.org/10.2147/CEG.S121056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868737PMC
March 2018
10 Reads

Postoperative pancreatic fistula: a review of traditional and emerging concepts.

Clin Exp Gastroenterol 2018 15;11:105-118. Epub 2018 Mar 15.

Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, Sydney, Australia.

Postoperative pancreatic fistula (POPF) remains the major cause of morbidity after pancreatic resection, affecting up to 41% of cases. With the recent development of a consensus definition of POPF, there has been a large number of reports examining various risk factors, prediction models, and mitigation strategies for this costly complication. Despite these strategies, the rates of POPF have not significantly diminished. Read More

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http://dx.doi.org/10.2147/CEG.S120217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858541PMC
March 2018
4 Reads

Clinical and laboratory features of intestinal tuberculosis.

Clin Exp Gastroenterol 2018 13;11:97-103. Epub 2018 Mar 13.

Department of Surgical Gastroenterology, Ronak Endo-laparoscopy and General Surgical Hospital, Patan, Gujarat, India.

Background/aims: As increasing numbers of Crohn's disease (CD) cases are being recognized in India, so the differential diagnosis of CD and gastrointestinal tuberculosis (GITB) is becoming increasingly important. If patients are misdiagnosed with GITB, toxicity may result from unnecessary anti-TB therapy and treatment of the primary disease (ie, CD) gets delayed. We therefore aimed to assess the accuracy of various parameters that can be used to predict GITB diagnosis at index evaluation. Read More

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http://dx.doi.org/10.2147/CEG.S154235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856297PMC
March 2018
5 Reads