Prolonged-release oxycodone/naloxone reduces opioid-induced constipation and improves quality of life in laxative-refractory patients: results of an observational study.
- Carsten Bantel,
- Shiva S Tripathi,
- David Molony,
- Tony Heffernan,
- Susmita Oomman,
- Vivek Mehta,
- Sara Dickerson
Clin Exp Gastroenterol 2018 24;11:57-67. Epub 2018 Jan 24.
Mundipharma International Limited, Cambridge, UK.
Background: Opioids are an effective treatment for moderate-to-severe pain. However, they are associated with a number of gastrointestinal side effects, most commonly constipation. Laxatives do not target the underlying mechanism of opioid-induced constipation (OIC), so many patients do not have their symptoms resolved. Read More