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    6144 results match your criteria Clinical and Experimental Allergy[Journal]

    1 OF 123

    Double-blind placebo-controlled trial of the effect of omalizumab on basophils in chronic urticaria patients.
    Clin Exp Allergy 2017 Nov 22. Epub 2017 Nov 22.
    Department of Rheumatology, Immunology and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Background: Omalizumab has been shown to be effective in treating chronic spontaneous urticaria (CSU). The reduction of FcεRI receptor density on the surface of basophils and mast cells is thought to play a major role in its effectiveness. We conducted a double-blind, randomized, placebo-controlled trial to investigate the mode of action of omalizumab in patients with antihistamine-resistant CSU. Read More

    Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: effects on allergic diseases.
    Clin Exp Allergy 2017 Nov 16. Epub 2017 Nov 16.
    Department of Medicine, McMaster University, Hamilton, Canada.
    Background: While allergic sensitization and atopic dermatitis (AD) are known to increase the risk for allergic diseases, the impact of different temporal and clinical patterns of sensitization and AD is less well defined.

    Objective: We investigated patterns of sensitization and AD from early infancy to age 3, and the differential risk for developing allergic diseases within each pattern in a general cohort.

    Methods: Children (n=2629) from the Canadian Healthy Infant Longitudinal Development (CHILD) Study underwent skin prick tests and were assessed clinically for AD at ages 1 and 3 years. Read More

    Asthma and Lung Function in Adulthood after a Viral Wheezing Episode in Early Childhood.
    Clin Exp Allergy 2017 Nov 16. Epub 2017 Nov 16.
    Pediatric Research Centre, Tampere University and Tampere University Hospital, Tampere, Finland.
    Background: Viral etiology of infection has a significant role in the long-term outcome of early-childhood wheezing.

    Objective: This study examines asthma and lung function in adulthood after early-childhood wheezing induced by respiratory syncytial virus (RSV) and rhinovirus (RV).

    Methods: A total of 100 children were hospitalized for a wheezing episode at less than 24 months of age from 1992 to 1993 in Kuopio University Hospital (Finland). Read More

    Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids.
    Clin Exp Allergy 2017 Nov 11. Epub 2017 Nov 11.
    MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, King's College London, London, SE1 9RT.
    Background: Subsets of patients with severe asthma remain symptomatic despite prolonged, high dosage glucocorticoid therapy. We hypothesised that the clinical glucocorticoid sensitivity of these asthmatics is reflected in differences in peripheral blood dendritic cell subsets.

    Objective: To compare peripheral blood leukocyte populations using flow cytometry at baseline and after 2 weeks of systemic glucocorticoid (steroid) treatment to identify immunological differences between steroid sensitive (SS) and steroid resistant (SR) asthmatics. Read More

    Effectiveness of alpine climate treatment for children with difficult to treat atopic dermatitis: results of a pragmatic randomized controlled trial (DAVOS trial).
    Clin Exp Allergy 2017 Nov 9. Epub 2017 Nov 9.
    Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.
    Background: Alpine climate treatment has historically been used in Europe to treat atopic dermatitis (AD), but no randomized trials have been conducted to provide evidence for its effectiveness.

    Objective: To investigate the long-term effectiveness of alpine climate treatment for children with difficult to treat AD.

    Materials & Methods: A pragmatic, open, randomized controlled trial was conducted. Read More

    Blood eosinophils: The forgotten man of inhaled steroid dose titration.
    Clin Exp Allergy 2017 Nov 8. Epub 2017 Nov 8.
    Scottish Centre for Respiratory Research, Ninewells Hospital & Medical School, Dundee, Scotland, DD1 9SY.
    Blood eosinophil counts which were once regarded as normal, have become of increasing interest in the era of Interluekin-5 (IL-5) asthma treatment. Blood eosinophils as low as 150 cells/μL have been suggested as treatment cut-offs for eosinophil depleting therapies such as mepolizumab [1], whilst a value of 300 cells/μL has been deemed a more pragmatic cut off by the National Institute for Health and Care Excellence (United Kingdom). In this era of eosinophil post-truths, inhaled corticosteroids (ICS), the eosinophil's oldest adversary, are very much the forgotten man. Read More

    Zoonotic helminth exposure and risk of allergic diseases: a study of two generations in Norway.
    Clin Exp Allergy 2017 Nov 8. Epub 2017 Nov 8.
    Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
    Background: Animal and human studies indicate that definitive host helminth infections may confer protection from allergies. However, zoonotic helminths, such as Toxocara species (spp.), have been associated with increased allergies. Read More

    Maternal folic acid use during pregnancy, MTHFR polymorphism, and child's lung function and asthma.
    Clin Exp Allergy 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pediatrics, Division of Respiratory Medicine.
    Background: Folic acid supplement use during pregnancy might affect childhood respiratory health, potentially mediated by methylenetetrahydrofolate-reductase polymorphism C677T (MTHFR-C677T) carriership.

    Objectives: We examined the associations of maternal folic acid supplement use and folate, vitamin B12 and homocysteine concentrations during pregnancy with childhood lung function and asthma.

    Methods: This study was embedded in a population-based prospective cohort study among 5,653 children. Read More

    Practice and Safety of Allergen Specific Immunotherapy for Allergic Rhinitis in the UK National Health Service: A report of 'real world' clinical practice.
    Clin Exp Allergy 2017 Nov 6. Epub 2017 Nov 6.
    Department of Allergy and Immunology, Heart of England NHS Foundation Trust, Birmingham Institute of Immunology and Immunotherapy, University of Birmingham, UK.
    Allergen specific immunotherapy (SIT) alleviates symptoms, improves health-related quality of life and alters the natural course of the disease in patients suffering from allergic rhinitis. It is currently delivered in the UK National Health Service (NHS) via 2 modalities namely subcutaneous injection immunotherapy (SCIT) and sublingual immunotherapy (SLIT). The latter has a superior safety profile - anaphylaxis is a rare occurrence. Read More

    Enhanced Antigen-presenting and T-cell Functions During Late-phase Allergic Responses in the Lung.
    Clin Exp Allergy 2017 Nov 3. Epub 2017 Nov 3.
    Johns Hopkins University, School of Medicine.
    Background: Allergic inflammation is a common feature of asthma and may contribute to both development and perpetuation of disease. The interaction of antigen presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines may determine the inflammatory response. Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional studies in humans have been limited. Read More

    The clinical relevance of lipid transfer protein.
    Clin Exp Allergy 2017 Nov 3. Epub 2017 Nov 3.
    UOC Immunologia e Allergologia, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milano.
    Despite a huge number of studies, many aspects of the lipid transfer protein (LTP)-syndrome, the most frequent primary food allergy in Mediterranean countries, remain unclear. Its peculiar geographical distribution, along with the extreme variability of its clinical expression make this type of food allergy something unique in the panorama of IgE-mediated food-induced allergic reactions. The present review article tried to summarize the current knowledge about the most important aspects of LTP sensitization and allergy, along with the importance of positive and negative co-factors in the clinical expression of the syndrome as well as the issues regarding the cross-reactivity between LTPs present in botanically related and unrelated foods. Read More

    Therapeutic administration of bone marrow-derived mesenchymal stromal cells reduces airway inflammation without upregulating Tregs in experimental asthma.
    Clin Exp Allergy 2017 Oct 25. Epub 2017 Oct 25.
    Laboratory of Clinical Bacteriology and Immunology, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Prophylactic administration of mesenchymal stromal cells (MSCs) derived from adipose (AD-MSC) and bone marrow tissue (BM-MSC) in ovalbumin-induced asthma hinders inflammation in a Treg-dependent manner. It is uncertain whether MSCs act through Tregs when inflammation is already established in asthma induced by a clinically relevant allergen.

    Objective: Evaluate the effect of therapeutic administration of MSCs on inflammation and Treg cells in house dust mite (HDM)-induced asthma. Read More

    Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy.
    Clin Exp Allergy 2017 Oct 25. Epub 2017 Oct 25.
    Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
    In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2016. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis, and clinical allergy are all covered. Read More

    Eosinophil persistence in vivo and sustained viability ex vivo in response to respiratory challenge with fungal allergens.
    Clin Exp Allergy 2017 Oct 25. Epub 2017 Oct 25.
    Inflammation Immunobiology Section, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA.
    Background: Eosinophils are immunomodulatory leucocytes that contribute to the pathogenesis of Th2-driven asthma and allergic lung diseases.

    Objective: Our goal was to identify unique properties of eosinophils recruited to the lungs and airways of mice in response to challenge with asthma-associated fungal allergens.

    Methods: Mice were challenged intranasally on days 0, 3 and 6 with a filtrate of Alternaria alternata. Read More

    Prebiotics for the prevention of allergies: A systematic review and meta-analysis of randomized controlled trials.
    Clin Exp Allergy 2017 Nov;47(11):1468-1477
    Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
    Background: Prevalence of allergic diseases in infants is approximately 10% reaching 20 to 30% in those with an allergic first-degree relative. Prebiotics are selectively fermented food ingredients that allow specific changes in composition/activity of the gastrointestinal microflora. They modulate immune responses, and their supplementation has been proposed as an intervention to prevent allergies. Read More

    Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis.
    Clin Exp Allergy 2017 Oct 13. Epub 2017 Oct 13.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
    Background: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis; however, the specific antipruritic mechanism of action remains unclear.

    Objective: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action.

    Methods: In this study, the effects of topical administration of HOCl hydrogel (0. Read More

    Enhancing antibiotic stewardship by tackling "spurious" penicillin allergy.
    Clin Exp Allergy 2017 Nov;47(11):1362-1373
    Department of Clinical Immunology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
    Approximately 90-99% of patients with a label of penicillin allergy (PenA) are not allergic when comprehensively investigated. An inaccurate label of PenA has major public health implications-longer hospital stay, more frequent hospital admissions, greater use of fluoroquinolones, glycopeptides, cephalosporins and other expensive antibiotics resulting in significantly higher costs to the health service and predisposing to Clostridium difficile, methicillin-resistant Staphylococcus aureus infections and vancomycin-resistant enterococcus. We describe lessons learnt from recent studies regarding possible reasons contributing to an inaccurate label of PenA as well as propose a concerted multidisciplinary approach to address this important public health problem. Read More

    Dust mite induces multiple polar T cell axes in human skin.
    Clin Exp Allergy 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: House dust mite/HDM atopy patch test/APT elicits positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals. Experimental systems for new-onset/chronic AD are needed to support rapid therapeutic development, particularly since animal models representing human AD are lacking. While HDM APT has been considered to simulate AD, its suitability to model AD's emerging Th2/Th22 phenotype with Th1 and Th17 components is unknown. Read More

    Inflammatory proteins in nasal lavage of workers exposed to occupational agents.
    Clin Exp Allergy 2017 Oct 4. Epub 2017 Oct 4.
    Research Center, Axe Maladies Chroniques, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
    Background: Low-molecular-weight (LMW) and high-molecular-weight (HMW) agents have been recognized as causes of occupational rhinitis (OR). Immunological mechanisms underlying OR differ according to the type of exposure. While HMW agents act mainly through IgE-mediated mechanisms, LMW agents appear to act through both immunological and non-immunological mechanisms. Read More

    Atopy in people aged 40 years and over: Relation to airflow limitation.
    Clin Exp Allergy 2017 Oct 3. Epub 2017 Oct 3.
    Respiratory Sleep and Environmental Health, Ingham Institute of Applied Medical Research, Sydney, NSW, Australia.
    Background: Previous studies have reached conflicting conclusions about the role of atopy as a risk factor for COPD. In part, this is attributable to variation in the definitions of airflow limitation and the treatment of people with asthma.

    Objective: To establish whether there is any independent association between atopy and post-bronchodilator airflow limitation in the general population aged 40 years and over. Read More

    Treatment of gastric eosinophilia by epicutaneous immunotherapy in piglets sensitized to peanuts.
    Clin Exp Allergy 2017 Sep 28. Epub 2017 Sep 28.
    Hôpital Necker, Université Paris-Descartes, Paris, France.
    Background: Eosinophilic gastrointestinal disorders (EGIDs) are hypersensitivity disorders frequently triggered by food allergy and manifested by mucosal eosinophilic infiltration at any level of the gastrointestinal tract. This study established a model of gastric eosinophilia in peanut-sensitized piglets to evaluate the efficacy of epicutaneous immunotherapy (EPIT) for its treatment.

    Methods: Experiments were carried out in piglets first sensitized by three intra-peritoneal injections of peanut protein extract (PPE) with adjuvant, and then given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy. Read More

    Small airway involvement in the late allergic response in asthma.
    Clin Exp Allergy 2017 Sep 21. Epub 2017 Sep 21.
    Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden.
    Background: Allergy and asthma are closely linked. Inhalation of allergen induces an early allergic response (EAR) within the airways of allergic asthmatic subjects, which is followed by a late allergic response (LAR) in approximately 50% of the subjects. The LAR is defined as a drop in forced expiratory volume in 1 second (FEV1 ) from baseline usually occurring 4-8 hours after exposure and is believed to affect small airways. Read More

    Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control.
    Clin Exp Allergy 2017 Sep 21. Epub 2017 Sep 21.
    Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
    Background: Classic spirometry is effort dependent and of limited value in assessing small airways. Peripheral airway involvement, and relation to poor control, in asthma, has been highlighted recently. Forced oscillation technique (FOT) offers an effort-independent assessment of overall and peripheral lung mechanics. Read More

    Haemoglobin concentrations in pregnancy and respiratory and allergic outcomes in childhood: Birth cohort study.
    Clin Exp Allergy 2017 Sep 21. Epub 2017 Sep 21.
    School of Social and Community Medicine, University of Bristol, Bristol, UK.
    Background: Limited epidemiological evidence suggests that low maternal iron status and anaemia in pregnancy may increase the risk of childhood respiratory and allergic outcomes.

    Objectives: To investigate the relation between maternal haemoglobin concentrations in pregnancy and childhood respiratory and allergic outcomes.

    Methods: In the Avon Longitudinal Study of Parents and Children (ALSPAC), we examined associations of maternal haemoglobin concentrations (g/dL) in pregnancy with hayfever, eczema, wheezing, doctor-diagnosed asthma, allergic sensitisation and total IgE at 7 years, and with lung function at 8-9 years in the offspring, after controlling for potential confounders (N = 3234-5335). Read More

    Determinants of low risk of asthma exacerbation during pregnancy.
    Clin Exp Allergy 2017 Sep 19. Epub 2017 Sep 19.
    Department of Pulmonary Medicine, Hvidovre Hospital, Hvidovre, Denmark.
    Background: Assessment of asthma control every 4-6 weeks during pregnancy is recommended to reduce risk of exacerbation, and by that improve outcome.

    Objective: To identify determinants of pregnancies with low risk of asthma exacerbation.

    Methods: All pregnant women enrolled into the Management of Asthma during Pregnancy (MAP) programme at Hvidovre Hospital since 2007. Read More

    Grandmaternal smoking increases asthma risk in grandchildren: A nationwide Swedish cohort.
    Clin Exp Allergy 2017 Sep 19. Epub 2017 Sep 19.
    Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Background: There is growing interest in exposures prior to conception as possible risk factors for offspring asthma. Although partially supported by evidence from limited human studies, current evidence is inconsistent and based on recall of exposure status.

    Objective: We aimed to investigate grandmaternal smoking during pregnancy and the risk of asthma in grandchildren using prospectively collected population-based data. Read More

    Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.
    Clin Exp Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
    Background: Little is known on the clinical relevance of peanut 2S albumin Ara h 7.

    Objective: To investigate the discriminative ability of Ara h 7 in peanut allergy and assess the role of cross-reactivity between Ara h 2, 6 and Ara h 7 isoforms.

    Methods: Sensitization to recombinant peanut storage proteins Ara h 1, 2, 3, 6, and 7 was assessed using a line blot in sera from 40 peanut-tolerant and 40 peanut-allergic patients, based on food challenge outcome. Read More

    IL-33 and IgE stimulate mast cell production of IL-2 and regulatory T cell expansion in allergic dermatitis.
    Clin Exp Allergy 2017 Nov 26;47(11):1409-1416. Epub 2017 Sep 26.
    Laboratory of Allergy and Clinical Immunology, The Herbert Mast Cell Disorders Center, Meir Medical Center, Kfar Saba, Israel.
    Background: We have previously shown that mast cells (MCs) suppress chronic allergic dermatitis in mice. The underlying mechanism involves MC-derived IL-2, which supports regulatory T cell (Treg) response at the site of inflammation. However, it is not clear what are the factors that drive MCs to produce IL-2. Read More

    Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control.
    Clin Exp Allergy 2017 Sep 8. Epub 2017 Sep 8.
    MACVIA-France, Contre les Maladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France.
    Background: Visual Analogue Scale (VAS) is a validated tool to assess control in allergic rhinitis patients.

    Objective: The aim of this study was to validate the use of VAS in the MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) app (Allergy Diary) on smartphones screens to evaluate allergic rhinitis symptoms and disease control.

    Methods: Each user filled 4 different VAS measuring overall, nasal, ocular, and asthma symptoms at least once. Read More

    Is a slow-progression baked milk protocol of oral immunotherapy always a safe option for children with cow's milk allergy? A randomized controlled trial.
    Clin Exp Allergy 2017 Nov 28;47(11):1491-1496. Epub 2017 Sep 28.
    Department of Allergology, Centre de l'Asthme et des Allergies, Hôpital d'Enfants, Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.

    Cholinergic urticaria patients of different age groups have distinct features.
    Clin Exp Allergy 2017 Sep 5. Epub 2017 Sep 5.
    Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Background: Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint-sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. Read More

    Differential regulation of PD-1 and its ligands in allergic asthma.
    Clin Exp Allergy 2017 Nov 12;47(11):1417-1425. Epub 2017 Oct 12.
    Department of Pneumology, University of Rostock, Rostock, Germany.
    Background: Targeting PD-1/PD-1 ligand signalling is an established treatment option for cancer. The role of these molecules in allergic asthma has been investigated in several mouse studies yielding conflicting results. However, human studies investigating the expression and regulation of PD-1 and its ligands in allergic inflammation are lacking. Read More

    Selective release of miRNAs via extracellular vesicles is associated with house dust mite allergen-induced airway inflammation.
    Clin Exp Allergy 2017 Aug 31. Epub 2017 Aug 31.
    Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kmicho, Itabashi-ku, Tokyo, 173-8610, Japan.
    Background: MicroRNAs (miRNAs) may facilitate cell-to-cell communication via extracellular vesicles (EVs). The biological roles of miRNAs in EVs on allergic airway inflammation is unclear.

    Methods: Airway secreted EVs (AEVs) were isolated from bronchoalveolar lavage fluid (BALF) of control and house dust mite (HDM) allergen-exposed HDM-sensitized mice. Read More

    BSACI guideline for the diagnosis and management of peanut and tree nut allergy.
    Clin Exp Allergy 2017 Jun;47(6):719-739
    Addenbrooke's Hospital, Cambridge, UK.
    Peanut nut and tree nut allergy are characterised by IgE mediated reactions to nut proteins. Nut allergy is a global disease. Limited epidemiological data suggest varying prevalence in different geographical areas. Read More

    Features of asthma which provide meaningful insights for understanding the disease heterogeneity.
    Clin Exp Allergy 2017 Aug 22. Epub 2017 Aug 22.
    Department of Medicine, Section of Paediatrics, Imperial College London, London, UK.
    Background: Data-driven methods such as hierarchical clustering (HC) and principal component analysis (PCA) have been used to identify asthma subtypes, with inconsistent results.

    Objective: To develop a framework for the discovery of stable and clinically meaningful asthma subtypes.

    Methods: We performed HC in a rich data set from 613 asthmatic children, using 45 clinical variables (Model 1), and after PCA dimensionality reduction (Model 2). Read More

    Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.
    Clin Exp Allergy 2017 Aug 22. Epub 2017 Aug 22.
    Department of Medicine Division of Pulmonary/Critical Care Medicine University of California San Francisco, San Francisco, CA, USA.
    Background: Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with corticosteroids alone or in combination with a long-acting β2 -adrenergic receptor agonist (LABA) on GCM in the bronchial epithelium are unknown.

    Objectives: To determine whether corticosteroid alone or in combination with a LABA alters protein and gene expression pathways associated with IL-13-induced goblet cell metaplasia.

    Results: We evaluated the effects of fluticasone propionate (FP) and of salmeterol (SM), on the response of well-differentiated cultured bronchial epithelial cells to interleukin-13 (IL-13). Read More

    Lipopolysaccharide suppresses IgE-mast cell-mediated reactions.
    Clin Exp Allergy 2017 Aug 21. Epub 2017 Aug 21.
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Background: Clinical and experimental analyses have identified a central role for IgE/FcεRI/mast cells in promoting IgE-mediated anaphylaxis. Recent data from human studies suggest that bacterial infections can alter susceptibility to anaphylaxis.

    Objective: We examined the effect of LPS exposure on the induction of IgE-mast cell (MC) mediated reactions in mice. Read More

    Infant feeding patterns and eczema in children in the first 6 years of life.
    Clin Exp Allergy 2017 Oct 4;47(10):1285-1298. Epub 2017 Sep 4.
    Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
    Background: Modes of infant feeding such as direct and indirect breastfeeding, and formula feeding, and their combinations may play a role in child health.

    Objective: The aim was to investigate which feeding patterns in the first 6 months pose risks of eczema/skin allergy in children up to 6 years compared to direct breastfeeding for at least 3 months.

    Methods: The Infant Feeding Practices Study II in the United States and its 6-year follow-up provided data on feeding modes in infancy and doctor's diagnosed eczema/skin allergy in the first 6 years of life (1387 infants), based on parental reports. Read More

    Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.
    Clin Exp Allergy 2017 Oct 11;47(10):1331-1341. Epub 2017 Sep 11.
    Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
    Background: Food allergy is an increasingly common health problem in Western populations. Epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori.

    Objective: The objective of this work was to investigate whether experimental infection with H. Read More

    Overcoming severe adverse reactions to venom immunotherapy using anti-IgE antibodies in combination with a high maintenance dose.
    Clin Exp Allergy 2017 Aug 12. Epub 2017 Aug 12.
    Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, Germany.
    Background: An omalizumab treatment and a high maintenance venom dose may both help to prevent recurrent systemic allergic reactions (SAR) to venom immunotherapy (VIT). The effectiveness of this combination therapy, however, is unclear.

    Objective: We wanted to explore the possibility whether a temporary treatment with the anti-IgE antibody omalizumab combined with a VIT using an elevated maintenance dose of >100 μg venom may establish a permanent tolerance of maintenance VIT. Read More

    Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens.
    Clin Exp Allergy 2017 Nov 5;47(11):1436-1444. Epub 2017 Sep 5.
    Department of Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Background: Workers exposed to laboratory animals have a high risk of developing laboratory animal allergy (LAA). Atopy seems to be the main risk factor for LAA. We hypothesized that occupational sensitization is a better predictor for the development of asthma, rhinitis, and bronchial hyperresponsiveness (BHR) than common sensitization. Read More

    Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study.
    Clin Exp Allergy 2017 Oct 4;47(10):1299-1308. Epub 2017 Sep 4.
    Wellcome Trust Centre for Global Health Research, Brighton & Sussex Medical School, Brighton, UK.
    Background: Epidemiological evidence from developed countries indicates that Helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders; however, limited data are available from low-income countries.

    Objective: We examined associations between H. pylori infection in early childhood and atopy and reported allergic disorders at the age of 6. Read More

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