6,431 results match your criteria Clinical and Experimental Allergy[Journal]


Epigenome Wide Association Studies in Asthma: A Systematic Review.

Clin Exp Allergy 2019 Apr 22. Epub 2019 Apr 22.

Department of Bioanalysis, Faculty of pharmaceutical sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent.

Objective: Asthma is a common, chronic respiratory airway disease influenced by environmental factors and possibly their interaction with the human genome causing epigenetic changes. Epigenome wide association studies (EWAS) have mainly investigated DNA methylation and its association with disease or traits, exposure factors or gene expression. This systematic review aimed to identify all EWAS assessing differentially methylated sites associated with asthma in humans. Read More

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http://dx.doi.org/10.1111/cea.13403DOI Listing

Idiopathic anaphylaxis.

Clin Exp Allergy 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Idiopathic anaphylaxis (IA) or spontaneous anaphylaxis is a diagnosis of exclusion when no cause can be identified. The exact incidence and prevalence of IA is not known. The clinical manifestations of IA are similar to other known causes of anaphylaxis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13402
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http://dx.doi.org/10.1111/cea.13402DOI Listing
April 2019
1 Read

Tumor necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis.

Clin Exp Allergy 2019 Apr 13. Epub 2019 Apr 13.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Background: Olfactory dysfunction is frequently experienced by patients with allergic rhinitis. It is thought to result from structural and functional changes occurring in the olfactory mucosa caused by inflammation. However, the current understanding of the pathophysiology of olfactory dysfunction in allergic rhinitis remains unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13401
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http://dx.doi.org/10.1111/cea.13401DOI Listing
April 2019
5 Reads

The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma.

Clin Exp Allergy 2019 Apr 12. Epub 2019 Apr 12.

Division of Asthma -Exacerbation& -Regulation, Priority Area Asthma & Allergy, Research Center Borstel- Leibniz Lung Center, Borstel, Germany.

Background: Originally, the neuropeptide α-melanocyte-stimulating hormone (α-MSH) has been described as a mediator of skin pigmentation. However, recent studies have shown that α-MSH is able to modulate inflammation in various tissues including the lung. So far, it is still not clear, whether α-MSH also plays a role in allergic bronchial asthma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13400
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http://dx.doi.org/10.1111/cea.13400DOI Listing
April 2019
5 Reads

Milk processing increases the allergenicity of cow's milk - preclinical evidence supported by a human proof-of-concept provocation pilot.

Clin Exp Allergy 2019 Apr 3. Epub 2019 Apr 3.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Background: Several studies demonstrated the adverse effect of milk processing on the allergy-protective capacity of raw cow's milk. Whether milk processing also affects the allergenicity of raw milk is hardly investigated.

Objective: To assess the allergenicity of raw (unprocessed) and processed cow's milk in a murine model for food allergy as well as in cow's milk allergic children. Read More

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http://dx.doi.org/10.1111/cea.13399DOI Listing

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III.

Clin Exp Allergy 2019 Apr 1. Epub 2019 Apr 1.

Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.

Introduction: The fractional exhaled nitric oxide (F NO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use F NO as a reliable biomarker, it is important to investigate factors that influence F NO in healthy individuals. Men have higher levels of F NO than women, but it is unclear whether determinants of F NO differ by sex. Read More

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http://dx.doi.org/10.1111/cea.13394DOI Listing
April 2019
2 Reads

Maternal IgG impairs the maturation of offspring intrathymic IL-17-producing γδT cells: Implications for murine and human allergies.

Clin Exp Allergy 2019 Mar 31. Epub 2019 Mar 31.

Laboratory of Medical Investigation LIM 56, Division of Clinical Dermatology, Medical School, University of Sao Paulo, Sao Paulo, Brazil.

Background: The precise mechanism involved in the acquisition of the IL-17+ profile of γδT cells, the ligands responsible for this change, and whether this default is acquired during intrathymic maturation need to be elucidated.

Objective: This study aimed to evaluate whether IL-17-producing γδT cells are present in the airways of tolerant offspring from allergen-sensitized mothers and the possible implication of maternal IgG in the generation of these cells.

Methods: Female mice were immunized or not, and the allergic response, frequency of γδT cell subsets and cytokine production of the offspring were analysed by flow cytometry. Read More

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http://dx.doi.org/10.1111/cea.13393DOI Listing

The chicken or the egg?

Authors:
G Roberts

Clin Exp Allergy 2019 Apr;49(4):396-397

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13385DOI Listing

Best of the other journals.

Clin Exp Allergy 2019 Apr;49(4):554-555

Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/cea.13387DOI Listing

Investigating the safety of capsaicin cough challenge in severe asthma.

Clin Exp Allergy 2019 Mar 25. Epub 2019 Mar 25.

Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13392
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http://dx.doi.org/10.1111/cea.13392DOI Listing
March 2019
3 Reads

Carotenoids, fatty acids, and disease burden in obese minority adolescents with asthma.

Clin Exp Allergy 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatrics, Albert Einstein College of Medicine, New York, US.

Background: Pediatric obesity-related asthma causes high disease burden, is associated with metabolic abnormalities, has few therapeutic options, and disproportionately affects urban minority children. Although poor diet quality is linked to asthma, the association of nutritional status with disease burden among children with obesity-related asthma is not well understood.

Objective: To quantify nutritional status, defined as concentrations of serum carotenoids and n-3 fatty acids, and its association with pulmonary function and metabolic markers among obese asthmatic children. Read More

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http://dx.doi.org/10.1111/cea.13391DOI Listing
March 2019
2 Reads

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma.

Clin Exp Allergy 2019 Mar 20. Epub 2019 Mar 20.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Background: Studies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings.

Objectives: To explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatics and controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13388
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http://dx.doi.org/10.1111/cea.13388DOI Listing
March 2019
5 Reads

Do eosinophils contribute to oxidative stress in mild asthma?

Clin Exp Allergy 2019 Mar 19. Epub 2019 Mar 19.

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/cea.13389DOI Listing
March 2019
1 Read

Maternal and neonatal 25-hydroxyvitamin D concentrations and school age lung function, asthma and allergy. The Generation R Study.

Clin Exp Allergy 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Division of Respiratory Medicine and Allergology.

Background: Vitamin D deficiency in early life might affect the developing lung and immune system, and subsequently influence the risk of asthma and allergy in later life.

Objective: We examined the associations of 25-hydroxyvitamin D concentrations in mid-gestation and at birth with lung function, asthma, inhalant allergic sensitization and inhalant allergy at school age.

Methods: This study among 4,951 children and their mothers was embedded in a population-based prospective cohort in Rotterdam, the Netherlands. Read More

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http://dx.doi.org/10.1111/cea.13384DOI Listing
March 2019
4.769 Impact Factor

Age at introduction to complementary solid food and food allergy and sensitization: A systematic review and meta-analysis.

Clin Exp Allergy 2019 Mar 12. Epub 2019 Mar 12.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.

Background And Objective: An infant's age at introduction of complementary solids may contribute to food allergy. We aimed to synthesize the literature on the association between age at introduction of complementary solids, excluding milk products, and food allergy and sensitization.

Design: We searched the electronic databases PubMed and EMBASE (January 1946-February 2017) using solid food, allergy and sensitization terms. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13383
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http://dx.doi.org/10.1111/cea.13383DOI Listing
March 2019
2 Reads

Critical role of CCL4 in eosinophil recruitment into the airway.

Clin Exp Allergy 2019 Mar 10. Epub 2019 Mar 10.

Department of General Medical Practice and Laboratory Diagnostic Medicine, Akita University Graduate School of Medicine, Akita, Japan.

Background: Excessive eosinophil airway infiltration is a clinically critical condition in some cases. Eosinophilic pneumonia (EP) is a pulmonary condition involving eosinophil infiltration of the lungs. Although several chemokines, including eotaxin-1 (CCL11), RANTES (CCL5) and macrophage inflammatory protein 1β (MIP-1β or CCL4), have been detected in bronchoalveolar lavage fluid (BALF) from patients with EP, the pathophysiological mechanisms underlying EP, including potential relationships between eosinophils and CCL4, have not been fully elucidated. Read More

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http://doi.wiley.com/10.1111/cea.13382
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http://dx.doi.org/10.1111/cea.13382DOI Listing
March 2019
8 Reads

It looks like childhood eczema but is it?

Clin Exp Allergy 2019 Mar 8. Epub 2019 Mar 8.

Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense C, Denmark.

In childhood, the most common type of eczema/dermatitis is atopic dermatitis, which occurs in up to 25% of children world-wide. However, the diagnosis may sometimes be challenging and atopic dermatitis may resemble other types of dermatitis as well as other skin diseases such as psoriasis, infections, infestations and malignancies as well as metabolic, genetic and autoimmune disorders. This review will focus on how to recognize the most common types of dermatitis in children and adolescents and how to separate them from the most common differential diagnoses clinically and histologically. Read More

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http://dx.doi.org/10.1111/cea.13381DOI Listing
March 2019
1 Read

Can we allow a further intake of drugs poorly suspected as responsible in drug reaction with eosinophilia and systemic symptoms (DRESS)? A study of practice.

Clin Exp Allergy 2019 Mar 4. Epub 2019 Mar 4.

Department of Dermatology and Allergology, Sorbonne Medecine University, Pharmacoepidemiology and healthcare assessment of the Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Tenon Hospital (APHP.6), Paris, France.

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http://dx.doi.org/10.1111/cea.13380DOI Listing

Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.

Clin Exp Allergy 2019 Mar 4. Epub 2019 Mar 4.

Department of Pediatrics, University of Cincinnati, Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: The "atopic march" has been considered a linear progression starting with eczema and culminating with development of asthma. Not all asthma cases, however, are preceded by eczema, and not all children with eczema go on to develop asthma.

Objective: The aim of this study was to explore the impact of allergic sensitization patterns on the association between early eczema and later childhood asthma. Read More

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http://dx.doi.org/10.1111/cea.13379DOI Listing
March 2019
4 Reads

Severe asthma - A population study perspective.

Clin Exp Allergy 2019 Feb 28. Epub 2019 Feb 28.

Dept of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, the OLIN unit, Umeå university, Umeå, Sweden.

Background: Severe asthma is a considerable challenge for patients, health care professionals and society. Few studies have estimated the prevalence of severe asthma according to modern definitions of which none based on a population study.

Objective: To describe characteristics and estimate the prevalence of severe asthma in a large adult population-based asthma cohort followed for 10-28 years. Read More

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http://dx.doi.org/10.1111/cea.13378DOI Listing
February 2019

Towards excellence in paediatric allergy care for all.

Clin Exp Allergy 2019 Mar;49(3):266-268

Cambridge University Hospitals, Cambridge, UK.

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http://dx.doi.org/10.1111/cea.13350DOI Listing

Best of the Other Journals.

Clin Exp Allergy 2019 Mar;49(3):392

Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/cea.13370DOI Listing
March 2019
1 Read

Sibs, low-level allergic sensitization and adolescents.

Authors:
G Roberts

Clin Exp Allergy 2019 Mar;49(3):264-265

Faculty of Medicine, Clinical and Experimental Sciences and Human Development and Health, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13368DOI Listing
March 2019
1 Read

Monitoring of respiratory resistance in the diagnosis of mild intermittent asthma.

Clin Exp Allergy 2019 Feb 23. Epub 2019 Feb 23.

Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.

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http://dx.doi.org/10.1111/cea.13376DOI Listing
February 2019

T cells in severe childhood asthma.

Clin Exp Allergy 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.

Severe asthma in children is a debilitating condition that accounts for a disproportionately large health and economic burden of asthma. Reasons for the lack of a response to standard anti-inflammatory therapies remain enigmatic. Work in the last decade has shed new light on the heterogeneous nature of asthma, and the varied immunopathologies of severe disease, which are leading to new treatment approaches for the individual patient. Read More

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http://dx.doi.org/10.1111/cea.13374DOI Listing
February 2019
1 Read

The impact of a General Practitioner-led community paediatric allergy clinic: A service evaluation.

Clin Exp Allergy 2019 Feb 21. Epub 2019 Feb 21.

MSc Allergy, University of Southampton, Southampton, UK.

Background: The NHS is not meeting the nation's allergy needs. There are insufficient allergy specialists, with variable care across the country. General practitioners (GPs) are lacking in allergy training. Read More

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http://dx.doi.org/10.1111/cea.13375DOI Listing
February 2019

The contribution of Tony Frew (1955-2018) to our understanding of Late-Phase Allergic Reactions.

Authors:
A Barry Kay

Clin Exp Allergy 2019 Apr 21;49(4):398-399. Epub 2019 Feb 21.

Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London, UK.

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http://dx.doi.org/10.1111/cea.13358DOI Listing

Asthma with multiple allergic comorbidities is associated with complete response to omalizumab.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Centre de l'Asthme et des Allergies, AP-HP, Groupe hospitalier Trousseau-La Roche Guyon, Paris, France.

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http://dx.doi.org/10.1111/cea.13373DOI Listing
February 2019

Nasal IgE production in allergic rhinitis: Impact of rhinovirus infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, University of Virginia Health System, Charlottesville, Virginia.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state, and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

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http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019
1 Read

Academic achievement of adolescents with asthma or atopic disease.

Clin Exp Allergy 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Over a fifth of children and adolescents suffer with asthma or atopic disease. It is unclear whether asthma impacts academic performance in children and adolescents, and little is known about the association of eczema, food allergy or hayfever and academic performance.

Objective: To examine whether asthma, eczema, food allergy or hayfever impacts on adolescent academic performance and to assess the role of unmeasured confounding. Read More

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http://dx.doi.org/10.1111/cea.13371DOI Listing
February 2019
2 Reads

Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.

Clin Exp Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.

Objective: We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2-agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness. Read More

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http://doi.wiley.com/10.1111/cea.13353
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http://dx.doi.org/10.1111/cea.13353DOI Listing
February 2019
12 Reads

Endothelin-1 mediates Aspergillus fumigatus-induced airway inflammation and remodelling.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, UK.

Background: Asthma is a chronic inflammatory condition of the airways and patients sensitized to airborne fungi such as Aspergillus fumigatus have more severe asthma. Thickening of the bronchial subepithelial layer is a contributing factor to asthma severity for which no current treatment exists. Airway epithelium acts as an initial defence barrier to inhaled spores, orchestrating an inflammatory response and contributing to subepithelial fibrosis. Read More

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http://dx.doi.org/10.1111/cea.13367DOI Listing
February 2019
2 Reads

Home-based cow's milk reintroduction using a milk ladder in children less than 3 years old with IgE-mediated cow's milk allergy.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Children's Allergy Service, University Hospitals of Leicester NHS Trust, Leicester, UK.

Background: The development of tolerance to cow's milk in allergic children is best determined by supervised baked milk exposure. Widely recommended hospital-based challenges can potentially delay contact because of resource limitations.

Objective: We sought to determine the efficacy and safety of our low-dose home-based reintroduction programme. Read More

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http://dx.doi.org/10.1111/cea.13366DOI Listing
February 2019
3 Reads

Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients.

Clin Exp Allergy 2019 Feb 7. Epub 2019 Feb 7.

University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia.

Background: Confirmation of the clinical relevance of sensitisation is important for the diagnosis of allergic rhinitis.

Objective: To investigate the usefulness of an in vitro basophil activation test and component-resolved diagnosis in distinguishing between symptomatic allergic rhinitis patients and asymptomatic sensitization to house dust mites (HDMs).

Methods: Thirty-six subjects with a positive skin prick test (SPT) for HDM were divided into a symptomatic (n = 17) and an asymptomatic (n = 19) group on the basis of their clinical history and a nasal provocation test. Read More

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http://dx.doi.org/10.1111/cea.13361DOI Listing
February 2019
1 Read

Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV.

Clin Exp Allergy 2019 Apr 20;49(4):541-544. Epub 2019 Feb 20.

Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/cea.13365DOI Listing
April 2019
2 Reads

Pentraxin 3 and D-dimer in children with asthma: A real-world study.

Clin Exp Allergy 2019 Apr 20;49(4):550-551. Epub 2019 Feb 20.

Allergy Clinic, Villa Montallegro, Genoa, Italy.

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http://dx.doi.org/10.1111/cea.13364DOI Listing
April 2019
1 Read

PTX3 and D-dimer in children with asthma: A real-world study-Reply.

Clin Exp Allergy 2019 Apr 27;49(4):552. Epub 2019 Feb 27.

Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Wuhan, China.

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http://dx.doi.org/10.1111/cea.13363DOI Listing

Levels of horse allergen Equ c 4 in dander and saliva from ten horse breeds.

Clin Exp Allergy 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala, Sweden.

Background: Horses are an important source of allergens, but the distribution of horse allergens is poorly understood. Five horse allergens have been identified, Equ c 1-4 and 6. Equ c 4 seems to be an important allergen, with an IgE-binding frequency of 77% in horse-sensitized individuals. Read More

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http://dx.doi.org/10.1111/cea.13362DOI Listing
February 2019
3 Reads

Food avoidance strategies in eosinophilic oesophagitis.

Clin Exp Allergy 2019 Mar;49(3):269-284

Division of Allergy and Immunology, The Children's Hospital of Phialdelphia, Phialdelphia, Pennsylvania.

Eosinophilic oesophagitis (EoE) is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity, a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton-pump inhibitor (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective. Read More

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http://dx.doi.org/10.1111/cea.13360DOI Listing
March 2019
3 Reads

Goblet cell hyperplasia as a feature of neutrophilic asthma.

Clin Exp Allergy 2019 Feb 1. Epub 2019 Feb 1.

Aix Marseille University, INSERM, INRA, C2VN, Marseille, France.

Background: Goblet cell hyperplasia (GCH) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production.

Objective: We aimed to decipher the clinical meanings and biological pathways related to GCH in non-smokers with asthma. Read More

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http://dx.doi.org/10.1111/cea.13359DOI Listing
February 2019
2 Reads

Quality and potency profile of eight recombinant isoallergens, largely mimicking total Bet v 1-specific IgE binding of birch pollen.

Clin Exp Allergy 2019 Jan 31. Epub 2019 Jan 31.

Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany.

Background: To date, only limited information on structure, expression levels and IgE binding of Bet v 1 variants, which are simultaneously expressed in birch pollen, is available.

Objective: To analyse and compare structure and serum IgE/IgG binding of rBet v 1 variants to Bet v 1.0101. Read More

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http://dx.doi.org/10.1111/cea.13356DOI Listing
January 2019

Seed storage 2S albumins are predictive indicators of exclusive Anacardiaceae cross-reactivity.

Clin Exp Allergy 2019 Apr 20;49(4):545-549. Epub 2019 Feb 20.

Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1111/cea.13357DOI Listing
April 2019
3 Reads

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.

Clin Exp Allergy 2019 01 29. Epub 2019 Jan 29.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Spain.

Background: Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome-wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. Read More

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http://dx.doi.org/10.1111/cea.13354DOI Listing
January 2019
1 Read

Best of the other journals.

Clin Exp Allergy 2019 Feb;49(2):259

Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/cea.13343DOI Listing
February 2019

Asthma and oral immunotherapy biomarkers.

Authors:
G Roberts

Clin Exp Allergy 2019 Feb;49(2):140-141

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13341DOI Listing
February 2019

Characterization of sensitization to furry animal allergen components in an adult population.

Clin Exp Allergy 2019 Apr 27;49(4):495-505. Epub 2019 Feb 27.

Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.

Objective: To characterize sensitization patterns to furry animal allergen components in Swedish adults. Read More

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http://dx.doi.org/10.1111/cea.13355DOI Listing

Incidental pharmacogenetics findings in an HLA-related research: Considerations for primary prevention.

Clin Exp Allergy 2019 Apr 22;49(4):537-540. Epub 2019 Feb 22.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

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http://dx.doi.org/10.1111/cea.13347DOI Listing
April 2019
10 Reads
4.769 Impact Factor

Dietary fats, olive oil and respiratory diseases in Italian adults: A population-based study.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Unit of Respiratory Diseases, Department of Internal Medicine, University of Verona, Verona, Italy.

Background: Fat intake has been associated with respiratory diseases, with conflicting results.

Objective: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population.

Methods: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case-control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with current asthma (CA), 77 with past asthma (PA), 305 with rhinitis and 344 controls. Read More

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http://dx.doi.org/10.1111/cea.13352DOI Listing
January 2019
1 Read

Angiopoietin-1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Background: Different mutations of the angiopoietin-1 gene (ANGPT1) have been associated with the occurrence of hereditary angioedema (HAE).

Objective: The purpose of the study is to clarify whether the ANGPT1 A119S variant plays its role via haploinsufficiency or a dominant negative effect.

Methods: The ability of ANGPT1 A119S variant to affect the endothelial barrier function was assessed by immunocytochemistry. Read More

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http://dx.doi.org/10.1111/cea.13349DOI Listing
January 2019
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Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brazil.

Background: The immunopathogenesis of severe asthma has been associated with an inefficient regulatory response. There are a few studies about the CD4 T cells profile among individuals with severe asthma refractory to treatment.

Objective: To evaluate the CD4 T lymphocyte profile from individuals with severe asthma according to their response to treatment, relating to their atopy status and age of asthma onset. Read More

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http://dx.doi.org/10.1111/cea.13351DOI Listing
January 2019
2 Reads