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    6260 results match your criteria Clinical and Experimental Allergy[Journal]

    1 OF 126

    Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis.
    Clin Exp Allergy 2018 Jun 16. Epub 2018 Jun 16.
    Clinical Research Center, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku Sagamihara, Kanagawa, Japan, 252-0392.
    Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and type-2 innate lymphoid cells (ILC2) are involved in the innate and type-2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown. Read More

    Greater Severity of Peanut Challenge Reactions Using a High fat versus Low Fat Matrix Vehicle.
    Clin Exp Allergy 2018 Jun 16. Epub 2018 Jun 16.
    University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Groningen, The Netherlands.
    Food allergy is a potentially life-threatening disease with a detrimental effect on the quality of life of caregivers and children.(1) Although many different types of food have been identified as potential elicitors of allergic reactions, only a small number of these foods cause the majority of reactions.(2) Food consists of a complex mixture of nutrient and non-nutrient components and their molecular interactions, which are known as the food matrix. Read More

    On the reliability of the CD123-endowed basophil activation test (BAT) and its application in food allergy.
    Clin Exp Allergy 2018 Jun 15. Epub 2018 Jun 15.
    Section of Immunology, AOUI Policlinico GB Rossi, Verona, Italy.
    the recent paper by Appel et al., evaluated the use of the basophil activaion test (BAT) in sesame allergy and concluded that BAT should be preferentially used in association with high protein sesame extract-skin prick test (HSPE-SPT) for the diagnosis of sesame food allergy, so preventing any ethical issue regarding the possble risk associated with oral food challenge (OFC) . The authors used a non commercial BAT approach endowed with the CD123 /HLADR phenotyping protocol and using CD63 and/or CD203c as activation markers . Read More

    Nasal Cytology: Methodology with application to clinical practice and research.
    Clin Exp Allergy 2018 Jun 15. Epub 2018 Jun 15.
    Section of Otolaryngology - Department of Basic Medical Science, Neuroscience and Sensory Organs - University of Bari, Bari, Italy.
    Nasal cytology is an easy, cheap, non-invasive and point-of-care method to assess nasal inflammation and disease-specific cellular features. By means of nasal cytology it is possible to distinguish between different inflammatory patterns that are typically associated with specific diseases (i.e. Read More

    A subset of walnut allergic adults is sensitized to walnut 11S globulin Jug r 4.
    Clin Exp Allergy 2018 Jun 15. Epub 2018 Jun 15.
    Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain allcases of walnut allergy.

    Objectives: Identify recognized walnut allergens, other than the ones previously investigated (Jug r 1-3), in walnut allergic adults and determine the sensitization frequency and diagnostic value.

    Methods: Three different in-house walnut extracts were prepared and analysed on SDS-PAGE blots to identify allergenic walnut proteins. Read More

    Local allergic rhinitis: implications for management.
    Clin Exp Allergy 2018 Jun 14. Epub 2018 Jun 14.
    Allergy Unit, IBIMA-Hospital Regional Universitario de Málaga, UMA, Málaga, Spain.
    A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. Read More

    The enigmatic role of the neutrophil in asthma: friend, foe or indifferent?
    Clin Exp Allergy 2018 Jun 14. Epub 2018 Jun 14.
    Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, United Kingdom.
    Whilst severe asthma has classically been categorised as a predominantly Th2 driven pathology, there has in recent years been a paradigm shift with the realisation that it is a heterogeneous disease that may manifest with quite disparate underlying inflammatory and remodelling profiles. A subset of asthmatics, particularly those with a severe, corticosteroid refractory disease, present with a prominent neutrophilic component. Given the potential of neutrophils to impart extensive tissue damage and promote inflammation, it has been anticipated that these cells are closely implicated in the underlying pathophysiology of severe asthma. Read More

    NLRP3 inflammasome: a likely target for the treatment of allergic diseases.
    Clin Exp Allergy 2018 Jun 13. Epub 2018 Jun 13.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
    Allergic diseases, such as asthma, rhinitis, dermatitis, conjunctivitis, and anaphylaxis, have recently become a global public health concern. According to previous studies, the NLRP3 inflammasome is a multi-protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen/damage-associated molecular signals, NLRP3 changes its conformation to allow the assembly of the NLRP3 inflammasome complex and activates caspase-1, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines IL-1β and IL-18. Read More

    Exploring what motivates and sustains support group engagement amongst young people with allergies: a qualitative study.
    Clin Exp Allergy 2018 Jun 14. Epub 2018 Jun 14.
    Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, 308232.
    Background: Positive self-care behaviours are more likely in young people who engage with allergy support groups, but reasons for this association are not well understood.

    Objectives: This study explored how and why young people engage with allergy support groups to identify what activities and resources are beneficial.

    Methods: In-depth, semi-structured interviews were conducted with young people aged 12-21 years who reported engaging with allergy support groups (in person or on-line). Read More

    Diagnosis of concomitant inducible laryngeal obstruction and asthma.
    Clin Exp Allergy 2018 Jun 5. Epub 2018 Jun 5.
    School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
    Background: Inducible laryngeal obstruction, an induced, inappropriate narrowing of the larynx, leading to symptomatic upper airway obstruction, can coexist with asthma. Accurate classification has been challenging because of overlapping symptoms and the absence of sensitive diagnostic criteria for either condition.

    Objective: To evaluate patients with concomitant clinical suspicion for inducible laryngeal obstruction and asthma. Read More

    Vaccines and atopic/allergic children: a survey among private pediatricians.
    Clin Exp Allergy 2018 May 31. Epub 2018 May 31.
    Department of Pediatric Pulmonology and Allergy, Timone Hospital, Marseille, France.
    The identification, assessment, and management of vaccine reactions, as well as vaccinations of atopic and allergic patients, particularly egg-allergic patients, have received several recent recommendations [1,2]. However, these recommendations are likely to be read mostly by practitioners specialized in infectious diseases or allergy rather than by primary care general practitioners or pediatricians. This article is protected by copyright. Read More

    Plasma Metabolite Profiles in Children with Current Asthma.
    Clin Exp Allergy 2018 May 28. Epub 2018 May 28.
    Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
    Background: Identifying metabolomic profiles of children with asthma has the potential to increase understanding of asthma pathophysiology.

    Objective: To identify differences in plasma metabolites between children with and without current asthma at mid-childhood.

    Methods: We used untargeted mass spectrometry to measure plasma metabolites in 237 children (46 current asthma cases and 191 controls) in Project Viva, a birth cohort from eastern Massachusetts, USA. Read More

    Novel genes and insights in complete asthma remission.
    Clin Exp Allergy 2018 May 22. Epub 2018 May 22.
    University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
    Background: Asthma is a chronic respiratory disease without a cure, though there exists spontaneous remission. Genome wide association(GWA) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission.

    Objectives: We performed a GWA study to develop insights in asthma remission. Read More

    Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up.
    Clin Exp Allergy 2018 May 21. Epub 2018 May 21.
    Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
    Background: A predisposition to exacerbations is being recognized as a distinct phenotype with "previous exacerbations" representing the strongest clinical factor associated with future exacerbation. Thus, to identify additional novel biomarkers associated with asthma exacerbations, "past exacerbation status" must be included as a confounding factor.

    Objective: This study aimed to characterize the clinical and biomarker features associated with asthma exacerbations in severe asthma. Read More

    Specialist perioperative allergy clinic services in the UK 2018: Results from the Royal College of Anaesthetists Sixth National Audit Project (NAP6) Investigation of Perioperative Anaphylaxis.
    Clin Exp Allergy 2018 May 19. Epub 2018 May 19.
    Honorary Consultant Anaesthetist, Manchester University NHS Foundation Trust; Honorary Clinical Professor of Perioperative Medicine, Manchester Academic Heath Science Centre, University of Manchester; NAP6 Clinical Lead, Royal College of Anaesthetists.
    Background: The Royal College of Anaesthetists 6th National Audit Project examined Grade 3-5 perioperative anaphylaxis for one year in the UK.

    Objective: To describe the causes and investigation of anaphylaxis in the NAP6 cohort, in relation to published guidance and previous baseline survey results.

    Methods: We used a secure registry to gather details of Grade 3-5 perioperative anaphylaxis. Read More

    Allergy in the elderly: case note review.
    Clin Exp Allergy 2018 May 19. Epub 2018 May 19.
    Department of Allergy & Respiratory Medicine, Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE.
    The prevalence of IgE-mediated disease increased significantly during the 20th century. In developed countries, about 20% of people have atopic disease, which consumes significant amounts of healthcare funding. For example, in UK general practice, allergic conditions account for 6% of consultations and ~10% of prescribing costs [1]. Read More

    Insights in particulate matter-induced allergic airway inflammation: Focus on the epithelium.
    Clin Exp Allergy 2018 May 17. Epub 2018 May 17.
    Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, Ghent, Belgium.
    Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. Read More

    Genetic profiles of transcriptomic clusters of childhood asthma determine specific severe subtype.
    Clin Exp Allergy 2018 May 14. Epub 2018 May 14.
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
    Background: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma.

    Objective: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients.

    Methods: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays. Read More

    Sputum-to-serum hydrogen sulphide ratio as a novel biomarker of predicting future risks of asthma exacerbation.
    Clin Exp Allergy 2018 May 14. Epub 2018 May 14.
    Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan.
    Background: Increased level of hydrogen sulphide (H S) in sputum is reported to be a new biomarker of neutrophilic airway inflammation in chronic airway disorders. However, the relationship between H S and disease activity remains unclear.

    Objective: We investigated whether H S levels could vary during different conditions in asthma. Read More

    Evaluation of the basophil activation test and skin prick testing for the diagnosis of sesame food allergy.
    Clin Exp Allergy 2018 May 14. Epub 2018 May 14.
    Institute of Allergy, Immunology and Pediatric Pulmonology, Assaf-Harofeh Medical Center, Zerifin, Israel.
    Background: The prevalence of sesame food allergy (SFA) has increased over recent years, with the potential of anaphylactic reactions upon exposure. Oral food challenge (OFC) remains the diagnostic standard, yet its implementation may be risky. Commercial skin prick tests (SPT) have a low sensitivity. Read More

    Pentraxin levels in noneosinophilic versus eosinophilic asthma.
    Clin Exp Allergy 2018 May 13. Epub 2018 May 13.
    Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, National Clinical Research Center of Respiratory Disease, Wuhan, Hubei, 430030, China.
    Background: Innate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or noneosinophilic asthma. Read More

    Src-type tyrosine kinase p56lck is critical for thymic stromal lymphopoietin-induced allergic rhinitis.
    Clin Exp Allergy 2018 May 12. Epub 2018 May 12.
    The Department of Food Science & Technology and Inflammatory Disease Research Center, Hoseo University, Asan, Republic of Korea.
    Background: Thymic stromal lymphopoietin (TSLP) is a regulator of mast cell-mediated allergic inflammatory reactions, but the manner in which TSLP contributes to allergic rhinitis (AR) remains unclear.

    Objective: Here, we sought to determine that TSLP plays a crucial role in AR by interacting with Src-type tyrosine kinase p56lck and STAT6 and promoting mast cells degranulation.

    Methods: The effects of TSLP on mast cell degranulation and AR were analysed in human mast cell line (HMC-1 cells), ovalbumin (OVA)-induced AR animal model, and human subjects. Read More

    Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma.
    Clin Exp Allergy 2018 May 12. Epub 2018 May 12.
    Department of Pathology & Medical Biology, Experimental Pulmonary and Inflammatory Research (EXPIRE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Background: Both subcutaneous and sublingual allergen immunotherapy (SCIT and SLIT) have been shown to effectively suppress allergic manifestations upon allergen exposure, providing long-term relief from symptoms in allergic disorders including allergic asthma. Clinical studies directly comparing SCIT and SLIT report a different kinetics and magnitude of immunological changes induced during treatment. Comparative studies into the mechanisms underlying immune suppression in SCIT and SLIT are lacking. Read More

    IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma.
    Clin Exp Allergy 2018 May 10. Epub 2018 May 10.
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
    Background: We have recently reported that sensitization to food allergens and sensitization to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma.

    Objective: To investigate the relation between IgE sensitization and several type 2 inflammation biomarkers in adult asthmatics.

    Methods: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study. Read More

    Sensitization to various minor house dust mite allergens is greater in patients with atopic dermatitis than in those with respiratory allergic disease.
    Clin Exp Allergy 2018 Apr 27. Epub 2018 Apr 27.
    Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Background: Various allergenic proteins are produced by house dust mites (HDM). However, the allergenicity and clinical implications of these allergens are unknown.

    Objective: The purpose of this study was to identify allergens in Dermatophagoides farinae and elucidate the sensitization profiles to these in Korean patients suffering from respiratory (allergic rhinitis and/or asthma) and atopic dermatitis symptoms. Read More

    Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation.
    Clin Exp Allergy 2018 Apr 27. Epub 2018 Apr 27.
    Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do, Korea.
    Background: P2Y10, along with GPR34 and GPR174, is a G protein-coupled receptor that is activated by an endogenous lipid mediator lysophosphatidylserine (LysoPS). Its expression pattern and its function are completely unknown. We have previously shown that P2Y10 is one of the highly up-regulated genes at the late differentiation stage during in vitro eosinophilopoiesis. Read More

    Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function.
    Clin Exp Allergy 2018 Apr 27. Epub 2018 Apr 27.
    Division of Immunology, Boston Children's Hospital and the Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
    Background: Oral immunotherapy (OIT) successfully desensitizes patients with food allergies, but the immune mechanisms mediating its efficacy remain obscure.

    Objectives: We tested the hypothesis that allergen-specific regulatory T (Treg) cell function is impaired in food allergy and is restored by anti-IgE antibody (omalizumab)-supplemented OIT.

    Methods: Peanut-specific T effector (Teff) and Treg cell proliferative responses, activation markers and cytokine expression were analysed by flow cytometry in 13 peanut-allergic subjects before the start of omalizumab-supplemented OIT and periodically in some subjects thereafter for up to 2 years. Read More

    Tree nut allergies: Allergen homology, cross-reactivity, and implications for therapy.
    Clin Exp Allergy 2018 Apr 27. Epub 2018 Apr 27.
    Department of Pediatrics, UNC School of Medicine, Chapel Hill, NC, USA.
    Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. Read More

    Short-term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France.
    Clin Exp Allergy 2018 Apr 26. Epub 2018 Apr 26.
    Réseau National de Surveillance Aérobiologique, Brussieu, France.
    Background: Outdoor moulds are classically associated with exacerbations of asthma.

    Objective: The aim of this paper was to examine nasal allergy morbidity by studying the short-term relationship between mould spore exposure and daily sales of reimbursable anti-allergic treatment in central France.

    Methods: The relationship between daily changes in mould concentrations and daily sales obtained from the national healthcare database was analysed with generalized additive models, taking into account confounding factors such as air pollution, weather conditions, pollen counts, and days of the week. Read More

    Low incidence of heparin-induced skin lesions in orthopedic surgery patients with low-molecular-weight heparins.
    Clin Exp Allergy 2018 Apr 23. Epub 2018 Apr 23.
    Department of Dermatology and Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
    Background: Heparins are widely prescribed for prevention and therapy of arterial and venous thromboembolic diseases. Heparin-induced skin lesions are the most frequent adverse effect of subcutaneous heparin treatment in non-surgical patients (7.5%-39. Read More

    Phase 2a, randomized, double-blind, placebo-controlled, multicentre, parallel-group study of an H R-antagonist (JNJ-39758979) in adults with uncontrolled asthma.
    Clin Exp Allergy 2018 Apr 23. Epub 2018 Apr 23.
    Janssen Research & Development, LLC, San Diego, CA, USA.
    Background: The effects of H R antagonists in preclinical asthma models support the study of antagonists of the H R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly selective oral H R antagonist.

    Objective: We sought to evaluate the safety and efficacy of the H R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. Read More

    FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy.
    Clin Exp Allergy 2018 Apr 22. Epub 2018 Apr 22.
    Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium.
    Background: In humans, both basophils and dendritic cells (DCs) express the high-affinity IgE receptor (FcεRI).

    Objective: To gain more insight into the relation between serum IgE levels and FcεRI expression and IgE binding by DCs and basophils in house dust mite (HDM) allergy and during subcutaneous immunotherapy (SCIT).

    Methods: We measured FcεRI, IgE and HDM allergen on DCs (conventional type 2 DCs, cDC2s; plasmacytoid dendritic cells, pDCs) and basophils by flow cytometry in 22 non-allergic vs 52 allergic subjects and upon HDM SCIT in 28 allergic subjects. Read More

    Working while unwell: Workplace impairment in people with severe asthma.
    Clin Exp Allergy 2018 Jun 17;48(6):650-662. Epub 2018 May 17.
    Centre of Excellence in Severe Asthma and Priority Research Centre for Healthy Lungs, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia.
    Background: Severe asthma affects quality of life; however, its impact on workplace productivity is poorly understood.

    Objective: To compare workplace productivity-absenteeism and presenteeism-and impairment in daily activities in severe and non-severe asthma over time and identify characteristics associated with presenteeism in severe asthma.

    Methods: The Severe Asthma Web-based Database is an ongoing observational registry from Australia, New Zealand and Singapore. Read More

    New insights into the phenotypes of atopic dermatitis linked with allergies and asthma in children: An overview.
    Clin Exp Allergy 2018 Apr 20. Epub 2018 Apr 20.
    Department of Allergology, Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy and triggers. A group of difficult-to-manage patients characterized by early-onset AD and severe lifelong disease associated with allergic asthma and/or food allergy (FA) has been identified. In this study, we focus on these severe phenotypes, analysing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta-analyses. Read More

    Peanut gastrointestinal delivery oral immunotherapy in adolescents: Results of the build-up phase of a randomized, double-blind, placebo-controlled trial (PITA study).
    Clin Exp Allergy 2018 Apr 17. Epub 2018 Apr 17.
    Service d'Immunologie, CHU Gabriel-Montpied, CHU Clermont-Ferrand, Clermont-Ferrand, France.
    Background: Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastrointestinal symptoms. In most protocols, peanut is administered in a vehicle food.

    Objective: In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (gastrointestinal delivery oral immunotherapy or GIDOIT) to bypass the upper gastrointestinal tract. Read More

    Proteomic analysis of serum and sputum analytes distinguishes controlled and poorly controlled asthmatics.
    Clin Exp Allergy 2018 Apr 17. Epub 2018 Apr 17.
    Department of Medicine, University of Vermont, Burlington, Vermont, USA.
    Background: A major goal of asthma therapy is to achieve disease control, with maintenance of lung function, reduced need for rescue medication, and prevention of exacerbation. Despite current standard of care, up to 70% of patients with asthma remain poorly controlled. Analysis of serum and sputum biomarkers could offer insights into parameters associated with poor asthma control. Read More

    Clinical implications of food allergen thresholds.
    Clin Exp Allergy 2018 Jun 4;48(6):632-640. Epub 2018 May 4.
    Pediatric Allergy Unit, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
    Food allergy has increased in recent decades and has a major impact on patients' quality of life. There is currently no treatment in routine clinical practice, and patients are often faced with accidental reactions. Precautionary allergen labelling (PAL) has been used by the food industry to attempt to minimize this risk, although not standardized and often ambiguous. Read More

    Remodelling and inflammation in preschoolers with severe recurrent wheeze and asthma outcome at school age.
    Clin Exp Allergy 2018 Mar 31. Epub 2018 Mar 31.
    Service de Pneumologie et Allergologie Pédiatriques, Hôpital Universitaire Necker-Enfants Malades, Paris, France.
    Background: The influence of airway remodelling and inflammation in preschoolers with severe recurrent wheeze on asthma outcomes is poorly understood.

    Objective: To assess their association with asthma symptoms and lung function at school age.

    Methods: Preschoolers (38. Read More

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