6,402 results match your criteria Clinical and Experimental Allergy[Journal]


Academic achievement of adolescents with asthma or atopic disease.

Clin Exp Allergy 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Over a fifth of children and adolescents suffer with asthma or atopic disease. It is unclear whether asthma impacts academic performance in children and adolescents, and little is known about the association of eczema, food allergy or hay fever and academic performance.

Objective: To examine whether asthma, eczema, food allergy or hay fever impacts on adolescent academic performance and to assess the role of unmeasured confounding. Read More

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http://dx.doi.org/10.1111/cea.13371DOI Listing
February 2019

Parental asthma and risk of autism spectrum disorder in offspring: a population and family based case-control study.

Clin Exp Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.

Objective: We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2-agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness. Read More

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http://doi.wiley.com/10.1111/cea.13353
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http://dx.doi.org/10.1111/cea.13353DOI Listing
February 2019
2 Reads

Endothelin-1 mediates Aspergillus fumigatus induced airway inflammation and remodelling.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, UK.

Background: Asthma is a chronic inflammatory condition of the airways and patients sensitised to airborne fungi such as Aspergillus fumigatus have more severe asthma. Thickening of the bronchial subepithelial layer is a contributing factor to asthma severity for which no current treatment exists. Airway epithelium acts as an initial defence barrier to inhaled spores, orchestrating an inflammatory response and contributing to subepithelial fibrosis. Read More

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http://dx.doi.org/10.1111/cea.13367DOI Listing
February 2019

Home-based cow's milk reintroduction using a milk ladder in children less than 3 years old with IgE-mediated cow's milk allergy.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Children's Allergy Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Background: The development of tolerance to cow's milk in allergic children is best determined by supervised baked milk exposure. Widely recommended hospital-based challenges can potentially delay contact because of resources limitations.

Objective: We sought to determine the efficacy and safety of our low-dose home-based reintroduction programme. Read More

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http://dx.doi.org/10.1111/cea.13366DOI Listing
February 2019
2 Reads

Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients.

Clin Exp Allergy 2019 Feb 7. Epub 2019 Feb 7.

University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia.

Background: Confirmation of the clinical relevance of sensitisation is important for the diagnosis of allergic rhinitis.

Objective: To investigate the usefulness of an in vitro basophil activation test and component-resolved diagnosis in distinguishing between symptomatic allergic rhinitis patients and asymptomatic sensitization to house dust mites (HDMs).

Methods: Thirty-six subjects with a positive skin prick test (SPT) for HDM were divided into a symptomatic (n=17) and an asymptomatic (n=19) group on the basis of their clinical history and a nasal provocation test. Read More

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http://dx.doi.org/10.1111/cea.13361DOI Listing
February 2019
1 Read

Airway smooth muscle reduction after Bronchial Thermoplasty in severe asthma correlates with FEV.

Clin Exp Allergy 2019 Feb 5. Epub 2019 Feb 5.

Amsterdam UMC, University of Amsterdam, Department of Pulmonology, Amsterdam, the Netherlands.

Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma patients in whom the airways are treated with radio-frequency energy with the aim to improve asthma symptoms by reducing airway smooth muscle (ASM). So far, three patient cohorts reported ASM mass reduction after BT by using α-smooth muscle actin staining (α-SMA). However, the exact mechanism of action of BT and its related responder profile is unclear. Read More

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http://dx.doi.org/10.1111/cea.13365DOI Listing
February 2019
1 Read

PTX3 and D-dimer in children with asthma: a real-world study.

Clin Exp Allergy 2019 Feb 5. Epub 2019 Feb 5.

Allergy Clinic, Villa Montallegro, Genoa, Italy.

Pathophysiological characteristics of asthma are: bronchial hyperresponsiveness, airway infiltration by inflammatory cells, and remodelling. Asthma treatment is targeted to achieve the best control of symptoms and risk factors. Anti-inflammatory agents are the most common medications used, since inflammation is the grounds of asthma. Read More

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http://dx.doi.org/10.1111/cea.13364DOI Listing
February 2019
1 Read

PTX3 and D-dimer in children with asthma: a real-world study-Reply.

Clin Exp Allergy 2019 Feb 5. Epub 2019 Feb 5.

Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Wuhan, Hubei, 430030, China.

Licari and colleagues detected plasma pentraxin 3 (PTX3) and serum D-dimer levels, and reported significant elevated concentrations for both biomarkers in asthmatic patients compared with healthy controls, but neither was observed to be associated with clinical parameters. Elevated PTX3 expressions in asthmatic airways were firstly observed by Zhang et al, and the same group reported that PTX3 deletion enhanced airway inflammation, mucus production, and airway hyperresponsiveness in an ovalbumin-induced asthma model through a TH17-dominant phenotype. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cea.13363DOI Listing
February 2019

Levels of horse allergen Equ C 4 in dander and saliva from ten horse breeds.

Clin Exp Allergy 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Sciences, Occupational and Environmental, Medicine, Uppsala University Hospital, SE, 75185, Uppsala, Sweden.

Background: Horses are an important source of allergens, but the distribution of horse allergens is poorly understood. Five horse allergens have been identified, Equ c 1-4 and 6. Equ c 4 seems to be an important allergen, with an IgE-binding frequency of 77% in horse-sensitized individuals. Read More

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http://dx.doi.org/10.1111/cea.13362DOI Listing
February 2019

Food avoidance strategies in eosinophilic oesophagitis.

Clin Exp Allergy 2019 Feb 3. Epub 2019 Feb 3.

University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, United States.

EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective. Read More

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http://dx.doi.org/10.1111/cea.13360DOI Listing
February 2019
2 Reads

Goblet Cell Hyperplasia as a feature of neutrophilic asthma.

Clin Exp Allergy 2019 Feb 1. Epub 2019 Feb 1.

Aix Marseille University, Inserm, INRA, C2VN, Marseille, France.

Background: Goblet Cell Hyperplasia (GCH) is a pathological finding classically reported across asthma severity levels and usually associated with smoking. Multiple biological mechanisms may contribute to excessive mucus production.

Objective: We aimed to decipher the clinical meanings and biological pathways related to GCH in non smokers with asthma. Read More

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http://dx.doi.org/10.1111/cea.13359DOI Listing
February 2019
1 Read

Quality and potency profile of eight recombinant isoallergens, largely mimicking total Bet v 1-specific IgE binding of birch pollen.

Clin Exp Allergy 2019 Jan 31. Epub 2019 Jan 31.

Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany.

Background: To date, only limited information on structure, expression levels and IgE binding of Bet v 1 variants, which are simultaneously expressed in birch pollen, is available.

Objective: To analyse and compare structure and serum IgE/IgG binding of rBet v 1 variants to Bet v 1.0101. Read More

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http://dx.doi.org/10.1111/cea.13356DOI Listing
January 2019

Seed storage 2S albumins are predictive indicators of exclusive Anacardiaceae cross-reactivity.

Clin Exp Allergy 2019 Jan 31. Epub 2019 Jan 31.

Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, Madrid, Spain.

Pistachio (Pistachio vera) and cashew nut (Anacardium occidentale), members of the Anacardiaceae family, account for a significant percentage of food allergies worldwide [1]. Nuts are one of the main causes of food anaphylaxis, eliciting a significant number of life-threatening reactions, which are aggravated by the fact that these allergens are often hidden in processed foods. Variability of allergic phenotypes to nut allergens with complex cross-reactivity profiles complicates clinical management of the patient [2]. Read More

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http://dx.doi.org/10.1111/cea.13357DOI Listing
January 2019
1 Read

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.

Clin Exp Allergy 2019 Jan 29. Epub 2019 Jan 29.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Spain.

Background: Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome-wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. Read More

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http://dx.doi.org/10.1111/cea.13354DOI Listing
January 2019

Best of the other journals.

Clin Exp Allergy 2019 Feb;49(2):259

Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/cea.13343DOI Listing
February 2019

Asthma and oral immunotherapy biomarkers.

Authors:
G Roberts

Clin Exp Allergy 2019 Feb;49(2):140-141

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13341DOI Listing
February 2019

Characterization of sensitization to furry animal allergen components in an adult population.

Clin Exp Allergy 2019 Jan 29. Epub 2019 Jan 29.

Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: There are paucity of data on sensitization to furry animal allergen components in adults. Furry animals are major sensitizers and contributors to asthma burden in northern Europe and North America.

Objective: To characterize sensitization patterns to furry animal allergen components in Swedish adults. Read More

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http://dx.doi.org/10.1111/cea.13355DOI Listing
January 2019

Incidental Pharmacogenetics Findings in an HLA-related Research: Considerations for Primary Prevention.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Perak, Malaysia.

Hypersensitivity drug reactions (HDRs) are an immense public health problem where significant proportions may lead to mortality. HDRs can manifest in various phenotypes, mainly cutaneous reactions that range from the mild; i.e. Read More

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http://dx.doi.org/10.1111/cea.13347DOI Listing
January 2019
8 Reads
4.769 Impact Factor

Dietary fats, olive oil and respiratory diseases in Italian adults: a population-based study.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Unit of Respiratory Diseases, Department of Internal Medicine, University of Verona, Verona, Italy.

Background: Fat intake has been associated with respiratory diseases, with conflicting results.

Objective: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population.

Methods: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with Current Asthma (CA), 77 with Past Asthma (PA), 305 with Rhinitis and 344 Controls. Read More

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http://dx.doi.org/10.1111/cea.13352DOI Listing
January 2019
1 Read

Angiopoietin-1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Backgound: Different mutations of the angiopoietin-1 gene (ANGPT1) have been associated with the occurrence of Hereditary Angioedema (HAE).

Objective: The purpose of the study is to clarify whether the ANGPT1 A119S variant plays its role via haploinsufficiency or a dominant negative effect.

Methods: The ability of ANGPT1 A119S variant to affect the endothelial barrier function was assessed by immunocytochemistry. Read More

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http://dx.doi.org/10.1111/cea.13349DOI Listing
January 2019
1 Read

Impaired immunoregulatory network of the cd4 t lymphocytes in refractory asthma.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.

Background: The immunopathogenesis of severe asthma has been associated with an inefficient regulatory response. There are a few studies about the CD4 T cells profile among individuals with severe asthma refractory to treatment.

Objective: To evaluate the CD4 T lymphocyte profile from individuals with severe asthma according to their response to treatment, relating to their atopy status and age of asthma onset. Read More

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http://dx.doi.org/10.1111/cea.13351DOI Listing
January 2019
1 Read

Gender, prick test size and rAra h 2 sIgE level may predict the eliciting dose in patients with peanut allergy: evidence from the Mirabel survey.

Clin Exp Allergy 2019 Jan 28. Epub 2019 Jan 28.

Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health Safety (ANSES), Maisons-Alfort, France.

Background: Peanut allergy management is based on active avoidance and access to emergency treatment including self-injectable adrenaline. Knowing the dose at which a patient is likely to react is crucial for risk assessment and could significantly improve management by integrating a personalized approach.

Objective: To develop a threshold dose distribution curve model from routinely collected data. Read More

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http://dx.doi.org/10.1111/cea.13348DOI Listing
January 2019
1 Read

Depressive symptom-associated IL-1β and TNF-α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma.

Clin Exp Allergy 2019 Jan 24. Epub 2019 Jan 24.

Pneumology Group, Department of Integrated Traditional Chinese and Western Medicine, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Background: Depressive symptoms worsen asthma outcomes; however, the mechanism remains largely unexplored.

Objective: This study aimed to determine whether depressive symptom-associated immune inflammation correlates with impaired bronchodilator response (BDR) and airway inflammatory phenotypes.

Methods: Eligible adults with asthma (n = 198) underwent clinical assessment, sputum induction and blood sampling. Read More

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http://doi.wiley.com/10.1111/cea.13346
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http://dx.doi.org/10.1111/cea.13346DOI Listing
January 2019
6 Reads

Pru p 7 sensitisation is a predominant cause of severe, cypress pollen-associated peach allergy.

Clin Exp Allergy 2019 Jan 23. Epub 2019 Jan 23.

Aix-Marseille Univ, IRD, IHU Méditerranée Infection, MEPHI, Marseille, France.

Background: Peach is a common elicitor of food allergic reactions. Peach-induced immediate reactions may occur as benign pollen-food syndromes, usually due to birch pollen related PR-10 cross-reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has has gained recent attention as a potential peach allergy severity marker. Read More

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http://doi.wiley.com/10.1111/cea.13345
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http://dx.doi.org/10.1111/cea.13345DOI Listing
January 2019
8 Reads

Comparison of inducible nitric oxide synthase mRNA expression in different airway portions and association with nitric oxide parameters from patients with asthma.

Clin Exp Allergy 2019 Jan 22. Epub 2019 Jan 22.

Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Mibumachi, Tochigi, Japan.

Background: Fractional exhaled nitric oxide concentration (FeNO) is widely used to support diagnosis and monitoring of bronchial asthma (BA). Tsoukias and George proposed a two-compartment model (2CM) for assessing the alveolar concentration of NO, referred to as CANO(2CM), while Condorelli et al proposed a model based on the trumpet shape of the airway tree and axial diffusion (TMAD), referred to as CANO(TMAD). In addition, Högman et al proposed non-linear model, referred to as CANO(non-linear). Read More

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http://dx.doi.org/10.1111/cea.13344DOI Listing
January 2019
2 Reads

A reintroduction of environmental mite allergen control strategies for asthma treatment and the debate on their effectiveness.

Clin Exp Allergy 2019 Jan 19. Epub 2019 Jan 19.

Department of Internal Medicine, Section of Allergology, Erasmus Medical Center, Rotterdam, The Netherland.

Asthma affects three hundred million people worldwide. The effectiveness of house dust mite allergen control for asthma treatment is debatable. One aspect that has been little discussed in existing meta-analyses is the possible role of environmental strategies. Read More

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http://doi.wiley.com/10.1111/cea.13340
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http://dx.doi.org/10.1111/cea.13340DOI Listing
January 2019
4 Reads

A randomized pilot trial of a school-based psychoeducational intervention for children with asthma.

Clin Exp Allergy 2019 Jan 18. Epub 2019 Jan 18.

University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Asthma is a common childhood illness with high morbidity and mortality among minority and socio-economically disadvantaged children. Disparities are not fully accounted for by differences in asthma prevalence, highlighting a need for interventions targeting factors associated with poorer asthma control. One such factor is psychological stress. Read More

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http://doi.wiley.com/10.1111/cea.13337
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http://dx.doi.org/10.1111/cea.13337DOI Listing
January 2019
10 Reads

Validation of childhood asthma predictive tools: A systematic review.

Clin Exp Allergy 2019 Jan 18. Epub 2019 Jan 18.

National Heart and Lung Institute, Imperial College London, London, UK.

Background: There is uncertainty about the clinical usefulness of currently available asthma predictive tools. Validation of predictive tools in different populations and clinical settings is an essential requirement for the assessment of their predictive performance, reproducibility and generalizability. We aimed to critically appraise asthma predictive tools which have been validated in external studies. Read More

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http://dx.doi.org/10.1111/cea.13336DOI Listing
January 2019
2 Reads

Identification and characterization of a naïve CD8+ T cell repertoire for benzylpenicillin.

Clin Exp Allergy 2019 Jan 18. Epub 2019 Jan 18.

Inflammation Chimiokines et Immunopathologie, INSERM, Fac de pharmacie, Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.

Background: Beta-lactams allergy is the most commonly reported drug allergy and constitutes an important health problem. We previously showed the pre-existence of a naïve CD4+ T cell repertoire for benzylpenicillin (BP) coupled to human serum albumin (HSA) but little is known about the naïve CD8+ T cell repertoire specific for BP.

Objective: The purpose of this work was to identify naïve CD8+ T cells specific for BP and to explore mechanisms dictating their activation. Read More

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http://dx.doi.org/10.1111/cea.13338DOI Listing
January 2019
12 Reads

Longitudinal analysis to better characterize Asthma-COPD overlap syndrome: Findings from an adult asthma cohort in Korea (COREA).

Clin Exp Allergy 2019 Jan 18. Epub 2019 Jan 18.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, Ulsan University School of Medicine, Seoul, Korea.

Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), which has received much attention, has not been unanimously defined.

Objective: In this study, we tried to demonstrate that longitudinally defined ACOS is more useful in the real world than blending patients with asthma and COPD.

Methods: The study patients had undergone two consecutive pulmonary function tests measured at least 3 months apart (n = 1889). Read More

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http://dx.doi.org/10.1111/cea.13339DOI Listing
January 2019
2 Reads

Do helminth infections underpin urban-rural differences in risk factors for allergy-related outcomes?

Clin Exp Allergy 2019 Jan 11. Epub 2019 Jan 11.

Immunomodulation and Vaccines Programme, (MRC/UVRI and LSHTM) Uganda Research Unit, Medical Research Council/Uganda Virus Research Institute, Entebbe, Uganda.

Background: It is proposed that helminth exposure protects against allergy-related disease, by mechanisms that include disconnecting risk factors (such as atopy) from effector responses.

Objective: We aimed to assess how helminth exposure influences rural-urban differences in risk factors for allergy-related outcomes in tropical low- and middle-income countries.

Methods: In cross-sectional surveys in Ugandan rural Schistosoma mansoni (Sm)-endemic islands, and in nearby mainland urban communities with lower helminth exposure, we assessed risk factors for atopy (allergen-specific skin prick test [SPT] reactivity and IgE [asIgE] sensitization) and clinical allergy-related outcomes (wheeze, urticaria, rhinitis and visible flexural dermatitis), and effect modification by Sm exposure. Read More

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http://dx.doi.org/10.1111/cea.13335DOI Listing
January 2019
13 Reads

Parent experiences with paediatric allergy pathways in the West Midlands: A qualitative study.

Clin Exp Allergy 2019 Jan 4. Epub 2019 Jan 4.

Department of Health Economics, University of Birmingham, Birmingham, UK.

Background: The prevalence, severity and complexity of allergic diseases have been increasing steadily in the United Kingdom over the last few decades. Primary care physicians are often not adequately trained in allergy management while specialist services for allergy are scarce and heterogeneous. Services, therefore, have been unable to meet the rising demand. Read More

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http://dx.doi.org/10.1111/cea.13334DOI Listing
January 2019
1 Read

Adherence to treatment in allergic rhinitis using mobile technology. the mask study.

Clin Exp Allergy 2018 Dec 31. Epub 2018 Dec 31.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Background: Mobile technology may help to better understand the adherence to treatment MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centered ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.

Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Read More

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http://dx.doi.org/10.1111/cea.13333DOI Listing
December 2018
5 Reads

Best of the Other Journals.

Clin Exp Allergy 2019 Jan;49(1):134

Addenbrooke's Hospital, Cambridge, UK.

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http://doi.wiley.com/10.1111/cea.13329
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http://dx.doi.org/10.1111/cea.13329DOI Listing
January 2019
6 Reads

Moving forward with improved food labelling for consumers with allergies.

Authors:
G Roberts

Clin Exp Allergy 2019 Jan;49(1):4-5

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://doi.wiley.com/10.1111/cea.13327
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http://dx.doi.org/10.1111/cea.13327DOI Listing
January 2019
6 Reads

Anthony J Frew.

Clin Exp Allergy 2019 Jan;49(1):135

Leukocyte Biology Section, National Heart & Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/cea.13330DOI Listing
January 2019
1 Read

Efficacy and safety of birch pollen allergoid subcutaneous immunotherapy: a 2-year double-blind, placebo-controlled, randomized trial plus 1-year open-label extension.

Clin Exp Allergy 2018 Dec 20. Epub 2018 Dec 20.

Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland.

Background: Previous clinical trials with birch pollen subcutaneous immunotherapy have been conducted over a 1-2 year treatment period and involved mostly a single geographic location.

Objective: This study (EudraCT-Number: 2005-000025-35) intended to evaluate the effect of subcutaneous immunotherapy with high-dose hypoallergenic birch pollen allergoid in patients with confirmed moderate to severe seasonal allergic rhinitis/rhinoconjunctivitis over a 3-year course in 19 European centers.

Methods: Adults with confirmed birch pollen allergy (n=253) were randomized to preseasonal placebo (n=129) or active treatment (n=124). Read More

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http://doi.wiley.com/10.1111/cea.13331
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http://dx.doi.org/10.1111/cea.13331DOI Listing
December 2018
8 Reads

Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema.

Clin Exp Allergy 2019 Feb 8;49(2):142-154. Epub 2019 Jan 8.

Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.

Angioedema is a rare adverse effect of the commonly used angiotensin-converting enzyme inhibitors (ACEi) and is reported to occur with a prevalence of 0.1%-0.7%. Read More

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http://dx.doi.org/10.1111/cea.13326DOI Listing
February 2019
5 Reads

Are environmental risk factors for current wheeze in the International Study of Asthma and Allergies in Childhood (ISAAC) phase three due to reverse causation?

Clin Exp Allergy 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.

Background: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors for asthma symptoms in combination, at both the individual and the school level, to explore the potential role of reverse causation due to selective avoidance or confounding by indication.

Objective: To explore the role of reverse causation in risk factors of asthma symptoms. Read More

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http://dx.doi.org/10.1111/cea.13325DOI Listing
December 2018
5 Reads

Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush desensitization (DS) is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More

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http://dx.doi.org/10.1111/cea.13323DOI Listing
December 2018
3 Reads

An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: B cells play a critical role in the development and maintenance of food allergy by producing allergen-specific IgE. Despite the importance of B cells in IgE-mediated food allergy, the identity of sIgE-producing human B cells and how IgE is regulated are poorly understood.

Objective: To identify the immunophenotypes of circulating B cells associated with the production of galactose-alpha-1,3-galactose-specific IgE production in patients with red meat allergy. Read More

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http://dx.doi.org/10.1111/cea.13322DOI Listing
December 2018
7 Reads

Best of the Other Journals.

Clin Exp Allergy 2018 Dec;48(12):1758

Addenbrooke's Hospital, Cambridge, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13317
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http://dx.doi.org/10.1111/cea.13317DOI Listing
December 2018
6 Reads

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy.

Clin Exp Allergy 2018 Dec;48(12):1606-1621

Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.

In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2017. Experimental models of allergic disease, basic mechanisms, clinical mechanisms, allergens, asthma and rhinitis and clinical allergy are all covered. Read More

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http://dx.doi.org/10.1111/cea.13318DOI Listing
December 2018
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Diagnostic and other challenges.

Authors:
G Roberts

Clin Exp Allergy 2018 Dec;48(12):1582-1583

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13315DOI Listing
December 2018
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Perinatal probiotic intervention prevented allergic disease in a Caesarean-delivered subgroup at 13-year follow-up.

Clin Exp Allergy 2018 Nov 25. Epub 2018 Nov 25.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial.

Objective: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. Read More

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http://dx.doi.org/10.1111/cea.13321DOI Listing
November 2018
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Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.

Clin Exp Allergy 2018 Nov 21. Epub 2018 Nov 21.

Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, New York.

Background: While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma and the role of maternal asthma control in pregnancy on the risk for asthma in the child.

Objective: We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3-year-old children and how prenatal and cord blood vitamin D status might affect this risk.

Methods: Data from 806 women, their partners (biologic fathers of the infants), and their children participated in the Vitamin D Antenatal Asthma Reduction Trail (VDAART, clinicaltrials. Read More

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http://dx.doi.org/10.1111/cea.13320DOI Listing
November 2018
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Individual risk assessment tool for school-age asthma prediction in UK birth cohort.

Clin Exp Allergy 2018 Nov 16. Epub 2018 Nov 16.

Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.

Background: Current published asthma predictive tools have moderate positive likelihood ratios (+LR) but high negative likelihood ratios (-LR) based on their recommended cut-offs, which limit their clinical usefulness.

Objective: To develop a simple clinically applicable asthma prediction tool within a population-based birth cohort.

Method: Children from the Manchester Asthma and Allergy Study (MAAS) attended follow-up at ages 3, 8 and 11 years. Read More

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http://doi.wiley.com/10.1111/cea.13319
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http://dx.doi.org/10.1111/cea.13319DOI Listing
November 2018
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Follow-up of patients with negative drug provocation tests to betalactams.

Clin Exp Allergy 2018 Nov 15. Epub 2018 Nov 15.

Département de Pneumologie et Addictologie, Hôpital Arnaud-de-Villeneuve, Centre Hospitalier Universitaire de Montpellier, Univ Montpellier, Montpellier, France.

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http://dx.doi.org/10.1111/cea.13314DOI Listing
November 2018
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Th2 cell differentiation from naive CD4 T cells is enhanced by autocrine CC chemokines in atopic diseases.

Clin Exp Allergy 2018 Nov 15. Epub 2018 Nov 15.

Department of Rheumatology, School of Medicine, Dokkyo Medical University, Mibu, Japan.

Background: Chemokines are involved not only in regulating leucocyte recruitment, but also in other activities. However, functions other than cell recruitment remain poorly understood. We have already shown that the production of CC chemokine ligand (CCL)17 and CCL22 by antigen-stimulated naïve CD4  T cells was higher in asthmatic patients than in healthy controls. Read More

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http://dx.doi.org/10.1111/cea.13313DOI Listing
November 2018
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Germination of pollen grains in the oesophagus of individuals with eosinophilic oesophagitis.

Clin Exp Allergy 2018 Nov 12. Epub 2018 Nov 12.

Biodiversity and Environmental Management, University of León, León, Spain.

Background: Eosinophilic oesophagitis (EoE) is characterized by oesophageal dysfunction and, histologically, by eosinophilic inflammation. There is no a clear aetiologic treatment. EoE exacerbations are often seasonal. Read More

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http://dx.doi.org/10.1111/cea.13312DOI Listing
November 2018
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