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    6118 results match your criteria Clinical and Experimental Allergy[Journal]

    1 OF 123

    Determinants of low risk of asthma exacerbation during pregnancy.
    Clin Exp Allergy 2017 Sep 19. Epub 2017 Sep 19.
    Department of Pulmonary Medicine, Hvidovre Hospital.
    Background: Assessment of asthma control every 4-6 weeks during pregnancy is recommended to reduce risk of exacerbation, and by that improve outcome.

    Objective: To identify determinants of pregnancies with low risk of asthma exacerbation.

    Methods: All pregnant women enrolled into the Management of Asthma during Pregnancy (MAP) program at Hvidovre Hospital since 2007. Read More

    Grandmaternal smoking increases asthma risk in grandchildren: a nationwide Swedish cohort.
    Clin Exp Allergy 2017 Sep 19. Epub 2017 Sep 19.
    Department of Public Health and Clinical Medicine, Umeå University, 90187, Sweden.
    Background: There is growing interest in exposures prior to conception as possible risk factors for offspring asthma. Although partially supported by evidence from limited human studies, current evidence is inconsistent, and based on recall of exposure status.

    Objective: We aimed to investigate grandmaternal smoking during pregnancy and the risk of asthma in grandchildren using prospectively collected population-based data. Read More

    Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.
    Clin Exp Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Little is known on the clinical relevance of peanut 2S albumin Ara h 7.

    Objective: To investigate the discriminative ability of Ara h 7 in peanut allergy and assess the role of cross-reactivity between Ara h 2, 6 and Ara h 7 isoforms.

    Methods: Sensitization to recombinant peanut storage proteins Ara h 1, 2, 3, 6 and 7 was assessed using a line blot in sera from 40 peanut tolerant and 40 peanut allergic patients, based on food challenge outcome. Read More

    IL-33 and IgE stimulate mast cell production of IL-2 and regulatory T cells expansion in allergic dermatitis.
    Clin Exp Allergy 2017 Sep 11. Epub 2017 Sep 11.
    Laboratory of Allergy and Clinical Immunology, The Herbert Mast Cell Disorders Center, Meir Medical Center, Kfar Saba, Israel.
    Background: We have previously shown that mast cells (MCs) suppress chronic allergic dermatitis in mice. The underlying mechanism involves MC-derived IL-2, which supports regulatory T cell (Treg) response at the site of inflammation. However, it is not clear what are the factors that drive MCs to produce IL-2. Read More

    Aspirin is an Enhancing Factor for Food-dependent Exercise-induced Anaphylaxis in Children.
    Clin Exp Allergy 2017 Sep 11. Epub 2017 Sep 11.
    Department of Pediatrics, National Hospital Organization Fukuoka Hospital.
    Food-dependent exercise-induced anaphylaxis (FDEIA) is typified by the onset of anaphylaxis during or soon after exercise preceded by the ingestion of a causal food. In Japan, a questionnaire-based prevalence study of 76,247 junior high-school students revealed an FDEIA prevalence of 0.017%. Read More

    Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control.
    Clin Exp Allergy 2017 Sep 8. Epub 2017 Sep 8.
    MACVIA-France, Contre les Maladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site, Montpellier, France.
    Background: Visual Analogue Scale (VAS) is a validated tool to assess control in allergic rhinitis patients.

    Objective: The aim of the present study was to validate the use of VAS in the MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) on smartphones screens to evaluate allergic rhinitis symptoms and disease control.

    Methods: Each user filled 4 different VAS measuring overall, nasal, ocular and asthma symptoms at least once. Read More

    Is a slow-progression baked-milk protocol of oral immunotherapy always a safe option for children with cow's milk allergy? A randomized controlled trial.
    Clin Exp Allergy 2017 Sep 5. Epub 2017 Sep 5.
    Department of Allergology-Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Immunoglobulin-E mediated-cow's milk allergy (IgE-CMA) is the one of the most frequent IgE mediated-food allergy in children in industrialized countries and may cause life- threatening anaphylaxis. The natural history of CM IgE mediated food allergy is favorable for most children. However, the clinical outcome of CMA seems worse than previously described, with less chance of recovery after the age of 3(1) . Read More

    Sequential hypoallergenic boiled peanut and roasted peanut oral immunotherapy.
    Clin Exp Allergy 2017 Sep 5. Epub 2017 Sep 5.
    Department of Human Physiology, Flinders University of South Australia, Australia.
    Oral immunotherapy (OIT) using roasted peanut flour can effectively desensitize peanut-allergic children [1] but is considered not to be ready for clinical practice [2] due to high rates (≥45%) of adverse events (AEs) [3] [4]. This necessitates medically supervised up-dosing in hospital and limits the number of patients that can be treated. In 2001 Beyer et. Read More

    Cholinergic urticaria patients of different age groups have distinct features.
    Clin Exp Allergy 2017 Sep 5. Epub 2017 Sep 5.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Berlin, Germany.
    Background: Cholinergic Urticaria (CholU) is a common skin disease characterized by the development of pinpoint sized wheals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. Read More

    Differential regulation of PD-1 and its ligands in allergic asthma.
    Clin Exp Allergy 2017 Sep 2. Epub 2017 Sep 2.
    Department of Pneumology, University of Rostock, Rostock, Germany.
    Background: Targeting PD-1/PD-1 ligand signalling is an established treatment option for cancer. The role of these molecules in allergic asthma has been investigated in several mouse studies yielding conflicting results. However, human studies investigating the expression and regulation of PD-1 and its ligands in allergic inflammation are lacking. Read More

    Selective release of miRNAs via extracellular vesicles is associated with house dust mite allergen-induced airway inflammation.
    Clin Exp Allergy 2017 Aug 31. Epub 2017 Aug 31.
    Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kmicho, Itabashi-ku, Tokyo, 173-8610, Japan.
    Background: MicroRNAs (miRNAs) may facilitate cell-to-cell communication via extracellular vesicles (EVs). The biological roles of miRNAs in EVs on allergic airway inflammation is unclear.

    Methods: Airway secreted EVs (AEVs) were isolated from bronchoalveolar lavage fluid (BALF) of control and house dust mite (HDM) allergen-exposed HDM-sensitized mice. Read More

    BSACI guideline for the diagnosis and management of peanut and tree nut allergy.
    Clin Exp Allergy 2017 Jun;47(6):719-739
    Addenbrooke's Hospital, Cambridge, UK.
    Peanut nut and tree nut allergy are characterised by IgE mediated reactions to nut proteins. Nut allergy is a global disease. Limited epidemiological data suggest varying prevalence in different geographical areas. Read More

    Features of asthma which provide meaningful insights for understanding the disease heterogeneity.
    Clin Exp Allergy 2017 Aug 22. Epub 2017 Aug 22.
    Department of Medicine, Section of Paediatrics, Imperial College London, London, UK.
    Background: Data-driven methods such as hierarchical clustering (HC) and principal component analysis (PCA) have been used to identify asthma subtypes, with inconsistent results.

    Objective: To develop a framework for the discovery of stable and clinically meaningful asthma subtypes.

    Methods: We performed HC in a rich data set from 613 asthmatic children, using 45 clinical variables (Model 1), and after PCA dimensionality reduction (Model 2). Read More

    Corticosteroid and Long-Acting ß-Agonist Therapy Reduces Epithelial Goblet Cell Metaplasia.
    Clin Exp Allergy 2017 Aug 22. Epub 2017 Aug 22.
    Department of Medicine Division of Pulmonary/Critical Care Medicine, University of California San Francisco, San Francisco, CA, 94143.
    Background: Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with corticosteroids, alone or in combination with a long-acting β2 -adrenergic receptor agonist (LABA) on GCM in the bronchial epithelium are unknown.

    Objectives: To determine if corticosteroid alone or in combination with a LABA alter protein and gene expression pathways associated with IL-13-induced goblet cell metaplasia.

    Results: We evaluated the effects of Fluticasone Propionate (FP) and of Salmeterol (SM), on the response of well-differentiated cultured bronchial epithelial cells to interleukin-13 (IL-13). Read More

    Lipopolysaccharide suppresses IgE-mast cell mediated reactions.
    Clin Exp Allergy 2017 Aug 21. Epub 2017 Aug 21.
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229.
    Background: Clinical and experimental analyses have identified a central role for IgE/FcεRI/mast cells in promoting IgE-mediated anaphylaxis. Recent data from human studies suggest that bacterial infections can alter susceptibility to anaphylaxis.

    Objective: We examined the effect of LPS exposure on the induction of IgE-mast cell-(MC) mediated reactions in mice. Read More

    Infant feeding patterns and eczema in children in the first 6 years of life.
    Clin Exp Allergy 2017 Aug 16. Epub 2017 Aug 16.
    Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
    Background: Modes of infant feeding such as direct and indirect breastfeeding, and formula feeding, and their combinations may play a role in child health.

    Objective: The aim was to investigate which feeding patterns in the first 6 months pose risks of eczema/skin allergy in children up to 6 years compared to direct breastfeeding for at least 3 months.

    Methods: The Infant Feeding Practices Study II in the United States and its 6-year follow-up provided data on feeding modes in infancy and doctor's diagnosed eczema/skin allergy in the first 6 years of life (1387 infants), based on parental reports. Read More

    Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.
    Clin Exp Allergy 2017 Aug 12. Epub 2017 Aug 12.
    Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.
    Background: Food allergy is an increasingly common health problem in Western populations. Epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori.

    Objective: The objective of this work was to investigate whether experimental infection with H. Read More

    Overcoming severe adverse reactions to venom immunotherapy by using anti-IgE antibodies in combination with a high maintenance dose.
    Clin Exp Allergy 2017 Aug 12. Epub 2017 Aug 12.
    Klinikum der Universitat Munchen, Klinik und Poliklinik für Dermatologie und Allergologie, Munchen, Bayern, Germany.
    Background: An omalizumab treatment and a high maintenance venom dose may both help to prevent recurrent systemic allergic reactions (SAR) to venom immunotherapy (VIT). The effectiveness of this combination therapy, however, is unclear.

    Objective: We wanted to explore the possibility whether a temporary treatment with the anti-IgE antibody omalizumab, combined with a VIT using an elevated maintenance dose of >100 μg venom may establish a permanent tolerance of maintenance VIT. Read More

    Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens.
    Clin Exp Allergy 2017 Aug 8. Epub 2017 Aug 8.
    Department of Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Background: Workers exposed to laboratory animals have a high risk of developing laboratory animal allergy (LAA). Atopy seems to be the main risk factor for LAA. We hypothesized that occupational sensitization is a better predictor for the development of asthma, rhinitis, and bronchial hyperresponsiveness (BHR) than common sensitization. Read More

    Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study.
    Clin Exp Allergy 2017 Aug 8. Epub 2017 Aug 8.
    Wellcome Trust Centre for Global Health Research, Brighton & Sussex Medical School, Brighton, UK.
    Background: Epidemiological evidence from developed countries indicates that Helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders; however, limited data are available from low-income countries.

    Objective: We examined associations between H. pylori infection in early childhood and atopy and reported allergic disorders at the age of 6. Read More

    Specialist perioperative allergy clinic services in the UK 2016: Results from the Royal College of Anaesthetists Sixth National Audit Project.
    Clin Exp Allergy 2017 Aug 8. Epub 2017 Aug 8.
    Pharmacy Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
    Background: Guidelines for investigation of perioperative drug allergy exist, but the quality of services is unknown. Specialist perioperative anaphylaxis services were surveyed through the Royal College of Anaesthetists 6(th) National Audit Project.

    Objectives: We compare self-declared UK practice in specialist perioperative allergy services with national recommendations. Read More

    The role of environmental exposure to peanut in the development of clinical allergy to peanut.
    Clin Exp Allergy 2017 Aug 5. Epub 2017 Aug 5.
    Division of Asthma, Allergy and Lung Biology, Department of Paediatric Allergy, King's College London and Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.
    The prevalence of peanut allergy has increased over the years and still remains one of the most common causes of food-related anaphylaxis. The way in which peanut sensitization occurs has been explored, such as via maternal consumption in pregnancy, via breastmilk and through a disrupted skin barrier. It has previously been shown that environmental exposure to aeroallergens in household dust can be a risk factor for the development of allergic asthma. Read More

    Hydrolysed ovalbumin offers more effective preventive and therapeutic protection against egg allergy than the intact protein.
    Clin Exp Allergy 2017 Aug 1. Epub 2017 Aug 1.
    Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.
    Background: The application of specific immunotherapy to stimulate oral tolerance towards food allergens is hampered by the high frequency of adverse side-effects and the excessive duration of the treatments.

    Objective: In this work, a hydrolysate of ovalbumin with pepsin (OP), selected for its low IgE reactivity and Th2-stimulating capacity, was assayed for its ability to prevent and treat allergy to egg white (EW).

    Methods: As a first step, the safety of OP, in terms of the absence of sensitizing and eliciting potential, was evaluated in BALB/c mice. Read More

    The effect of allergen-induced bronchoconstriction on concentration of 5-oxo-ETE in exhaled breath condensate of house dust mite-allergic patients.
    Clin Exp Allergy 2017 Aug 1. Epub 2017 Aug 1.
    Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland.
    Background: Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion.

    Objective: The aim of this study was to evaluate concentration of selected 5-lipoxygenase- and cyclooxygenase-derived eicosanoids in exhaled breath condensate (EBC) during allergen-induced bronchoconstriction.

    Methods: The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs). Read More

    Accurate quantification of 5 German cockroach (GCr) allergens in complex extracts using multiple reaction monitoring mass spectrometry (MRM MS).
    Clin Exp Allergy 2017 Jul 30. Epub 2017 Jul 30.
    Laboratory of Immunobiochemistry, Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research and Review, CBER/FDA, Silver Spring, MD, USA.
    Background: German cockroach (GCr) allergen extracts are complex and heterogeneous products, and methods to better assess their potency and composition are needed for adequate studies of their safety and efficacy.

    Objective And Methods: The objective of this study was to develop an assay based on liquid chromatography and multiple reaction monitoring mass spectrometry (LC-MRM MS) for rapid, accurate, and reproducible quantification of 5 allergens (Bla g 1, Bla g 2, Bla g 3, Bla g 4, and Bla g 5) in crude GCr allergen extracts.

    Results: We first established a comprehensive peptide library of allergens from various commercial extracts as well as recombinant allergens. Read More

    Factors influencing the quality of Myrmecia pilosula (Jack Jumper) ant venom for use in in vitro and in vivo diagnoses of allergen sensitization and in allergen immunotherapy.
    Clin Exp Allergy 2017 Jul 30. Epub 2017 Jul 30.
    Jack Jumper Allergy Program, Royal Hobart Hospital, Hobart, Tas., Australia.
    Background: Allergen immunotherapy uses pharmaceutical preparations derived from naturally occurring source materials, which contain water-soluble allergenic components responsible for allergic reactions. The success of in vivo and in vitro diagnoses in allergen sensitization and allergen immunotherapy largely depends on the quality, composition and uniformity of allergenic materials used to produce the active ingredients, and the formulation employed to prepare finished products.

    Objectives: We aimed to examine the factors influencing batch-to-batch consistency of Jack Jumper (Myrmecia pilosula) ant venom (JJAV) in the form of active pharmaceutical ingredient (AI) and informed whether factors such as temperature, artificial light and container materials influence the quality of JJAV AIs. Read More

    DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.
    Clin Exp Allergy 2017 Jul 30. Epub 2017 Jul 30.
    NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
    Background: There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered epigenetic regulation of genes.

    Objective And Methods: To determine the relationship between variations in DNA methylation at birth and the development of allergic disease, we examined the methylation status of CpG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and TBET) in umbilical cord DNA at birth in a cohort of infants from the Southampton Women's Survey (n = 696) who were later assessed for asthma, atopic eczema and atopy.

    Results: We found that higher methylation of GATA3 CpGs -2211/-2209 at birth was associated with a reduced risk of asthma at ages 3 (median ratio [median methylation in asthma group/median methylation in non-asthma group] = 0. Read More

    A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial.
    Clin Exp Allergy 2017 Jul 15. Epub 2017 Jul 15.
    Imperial College Healthcare NHS Trust, London, UK.
    Background: Mothers of children with food allergy have increased anxiety, which may be influenced by healthcare professionals' communication of risk.

    Objective: To evaluate a brief psychological intervention for reducing anxiety in mothers of children with food allergy.

    Methods: Two hundred mothers of children with food allergy were recruited from allergy clinics. Read More

    Food allergy phenotypes: The key to personalized therapy.
    Clin Exp Allergy 2017 Sep;47(9):1125-1137
    Asthma and Allergy Center, Hôpital d'Enfants Armand, Sorbonne Universités, UPMC Univ Paris 06 - Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
    Food allergies (FAs) are of increasing public health concern and are characterized by a large spectrum of diseases. Their diversity is well known for immunologic pathways (IgE, non-IgE-mediated FAs) and natural history. Many other factors and patient characteristics are involved including type of food, exposure route, allergic comorbidities, gender, racial and ethnic backgrounds, cofactors and health conditions. Read More

    Identification of unique proteomic signatures in allergic and non-allergic skin disease.
    Clin Exp Allergy 2017 Jul 13. Epub 2017 Jul 13.
    MedImmune, LLC, Gaithersburg, MD, USA.
    Background: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).

    Objective: Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation. Read More

    Dose-response relationship of a new Timothy grass pollen allergoid in comparison to a 6-grass pollen allergoid.
    Clin Exp Allergy 2017 Jul 11. Epub 2017 Jul 11.
    Center for Rhinology and Allergology Wiesbaden, Germany.
    Background: Subcutaneous allergen immunotherapy with grass pollen allergoids has been proven to be effective and safe in the treatment of patients with allergic rhinoconjunctivitis. Based on the extensive cross-reactivity among Pooideae species, it has been suggested that grass pollen extracts could be prepared from a single species, rather than from a multiple species mixture.

    Objective: To find the optimal dose of a Phleum pratense allergoid preparation and compare its efficacy and safety to a 6-grass pollen allergoid preparation. Read More

    Patient-reported signs of dampness at home may be a risk factor for chronic rhinosinusitis: A cross-sectional study.
    Clin Exp Allergy 2017 Jul 11. Epub 2017 Jul 11.
    Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
    Background: An association between dampness at home and respiratory conditions has been convincingly demonstrated in children. Fewer studies have been performed in adults, and data are lacking for chronic rhinosinusitis (CRS). With a prevalence of 10. Read More

    Invariant natural killer cells change after an oral allergy desensitization protocol for cow's milk.
    Clin Exp Allergy 2017 Jul 7. Epub 2017 Jul 7.
    Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Background: Cow milk (CM) allergy (CMA) affects up to 3% of the paediatric population and recent data suggest that only about 50% will outgrow by age 8. Oral immunotherapy (OIT) is a type of immune-modulating treatment that is able to induce desensitization to food allergens, to increase tolerance threshold, to reduce the risk of anaphylaxis, and to improve the patient's quality of life. The examination of the immunological changes observed during the establishment of food allergy (FA) desensitization in FA patients is a window into the pathogenesis of food allergy and food tolerance development. Read More

    Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial.
    Clin Exp Allergy 2017 Sep 11;47(9):1193-1203. Epub 2017 Aug 11.
    GlaxoSmithKline, Stevenage, Hertfordshire, UK.
    Background: Toll-like receptor 7 (TLR7) stimulation in the airways may reduce responses to aeroallergens by induction of type 1 interferons (IFNs). GSK2245035 is a novel selective TLR7 agonist in pharmaceutical development.

    Objective: Assessment of safety, pharmacodynamics and nasal allergic reactivity following repeated weekly intranasal (i. Read More

    Comorbidities in adults with asthma: Population-based cross-sectional analysis of 1.4 million adults in Scotland.
    Clin Exp Allergy 2017 Jun 30. Epub 2017 Jun 30.
    Division of Population Health Sciences, School of Medicine, University of Dundee, Dundee, UK.
    Background: Comorbidity in people with asthma can significantly increase asthma morbidity and lower adherence to asthma guidelines.

    Objective: The objective of this study was to comprehensively measure the prevalence of physical and mental health comorbidities in adults with asthma using a large nationally representative population.

    Methods: Cross-sectional analysis of routine primary care electronic medical records for 1 424 378 adults in the UK, examining the prevalence of 39 comorbidities in people with and without asthma, before and after adjustment for age, sex, social deprivation and smoking status using logistic regression. Read More

    Bronchoprotective tolerance with indacaterol is not modified by concomitant tiotropium in persistent asthma.
    Clin Exp Allergy 2017 Jun 30. Epub 2017 Jun 30.
    Scottish Centre for Respiratory Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
    Background: Tiotropium is a long acting muscarinic antagonist (LAMA), licensed as triple therapy with inhaled corticosteroid and long-acting beta-agonist (ICS/LABA). There may be a synergistic benefit between LAMA and LABA as a consequence of receptor cross-talk, which in turn could modify beta-2 receptor downregulation and associated tolerance induced by LABA.

    Objective: We hypothesize this mechanism may result in a reduction of airway hyperresponsiveness (AHR) when using triple therapy. Read More

    A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype.
    Clin Exp Allergy 2017 Jun 28. Epub 2017 Jun 28.
    Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
    Background: Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases. The phenotypes that have clinical features of both asthma and COPD are still incompletely understood.

    Objective: To clarify the best discriminators of the asthma-COPD overlap phenotype from asthma and COPD subgroups using a clustering approach. Read More

    Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma.
    Clin Exp Allergy 2017 Sep 10;47(9):1159-1169. Epub 2017 Jul 10.
    Department of Respiratory Medicine, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
    Background: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Read More

    Mechanisms underlying induction of allergic sensitization by Pru p 3.
    Clin Exp Allergy 2017 Jun 15. Epub 2017 Jun 15.
    Centre for Plant Genomics and Biotechnology (UPM-INIA), Pozuelo de Alarcon, Madrid, Spain.
    Background: Recently, the nature of the lipid-ligand of Pru p 3, one of the most common plant food allergens in southern Europe, has been identified as a derivative of the alkaloid camptothecin bound to phytosphingosine. However, the origin of its immunological activity is still unknown.

    Objective: We sought to evaluate the role of the Pru p 3 lipid-ligand in the immunogenic activity of Pru p 3. Read More

    Road map for the clinical application of the basophil activation test in food allergy.
    Clin Exp Allergy 2017 Sep 1;47(9):1115-1124. Epub 2017 Aug 1.
    Department of Pediatrics, Division of Allergy and Immunology, Food Allergy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    The diagnosis of IgE-mediated food allergy based solely on the clinical history and the documentation of specific IgE to whole allergen extract or single allergens is often ambiguous, requiring oral food challenges (OFCs), with the attendant risk and inconvenience to the patient, to confirm the diagnosis of food allergy. This is a considerable proportion of patients assessed in allergy clinics. The basophil activation test (BAT) has emerged as having superior specificity and comparable sensitivity to diagnose food allergy, when compared with skin prick test and specific IgE. Read More

    Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016-results from three population surveys.
    Clin Exp Allergy 2017 Jun 13. Epub 2017 Jun 13.
    Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN unit, Umeå University, Umeå, Sweden.
    Background: During the latter half of the 20th century, the prevalence of asthma and many other allergic diseases has increased. Information on asthma prevalence trends among adults after 2010, especially regarding studies separating allergic asthma from non-allergic asthma, is lacking.

    Objective: The aim was to estimate prevalence trends of current asthma among adults, both allergic and non-allergic, from 1996 to 2016. Read More

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