4,417,012 results match your criteria Clinical anatomy New York N.Y.[Journal]


The double burden of food insecurity and obesity among Latino youth: Understanding the role of generational status.

Pediatr Obes 2019 Apr 25:e12525. Epub 2019 Apr 25.

Department of Public Health Education, University of North Carolina, Greenboro, NC, USA.

Background: Obesity is linked to food insecurity and generational status; however, little is known about how both impact obesity risk among Latino youth.

Objective: To investigate the joint effect of generational status and food insecurity on obesity prevalence among Latino youth.

Methods: We pooled data from the 2011 to 2017 waves of the National Health Interview Survey to derive a sample Latino youth aged 12 to 17 (N = 7532). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijpo.12525DOI Listing

Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.

Background:  Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection of proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission is a diagnostic marker for perforation in children with AA.

Materials And Methods:  This was a prospective diagnostic accuracy study, including previously healthy children, 1 to 14 years of age, with AA. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687870
Publisher Site
http://dx.doi.org/10.1055/s-0039-1687870DOI Listing
April 2019
1 Read

An Open Science Approach to Artificial Intelligence in Healthcare.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Kyoto University, Japan.

Objectives: Artificial Intelligence (AI) offers significant potential for improving healthcare. This paper discusses how an "open science" approach to AI tool development, data sharing, education, and research can support the clinical adoption of AI systems.

Method: In response to the call for participation for the 2019 International Medical Informatics Association (IMIA) Yearbook theme issue on AI in healthcare, the IMIA Open Source Working Group conducted a rapid review of recent literature relating to open science and AI in healthcare and discussed how an open science approach could help overcome concerns about the adoption of new AI technology in healthcare settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677898DOI Listing

Artificial Intelligence in Clinical Decision Support: Challenges for Evaluating AI and Practical Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Macquarie University, Australian Institute of Health Innovation, Sydney, Australia.

Objectives: This paper draws attention to: i) key considerations for evaluating artificial intelligence (AI) enabled clinical decision support; and ii) challenges and practical implications of AI design, development, selection, use, and ongoing surveillance.

Method: A narrative review of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.

Results: There is a rich history and tradition of evaluating AI in healthcare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677903DOI Listing

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

Role of Artificial Intelligence within the Telehealth Domain.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

IBM Research, Brazil.

Objectives: This paper provides a discussion about the potential scope of applicability of Artificial Intelligence methods within the telehealth domain. These methods are focussed on clinical needs and provide some insight to current directions, based on reports of recent advances.

Methods: Examples of telehealth innovations involving Artificial Intelligence to support or supplement remote health care delivery were identified from recent literature by the authors, on the basis of expert knowledge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677897DOI Listing

Artificial Intelligence for Participatory Health: Applications, Impact, and Future Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Swinburne University of Technology, and University of Melbourne, Australia.

Objective: Artificial intelligence (AI) provides people and professionals working in the field of participatory health informatics an opportunity to derive robust insights from a variety of online sources. The objective of this paper is to identify current state of the art and application areas of AI in the context of participatory health.

Methods: A search was conducted across seven databases (PubMed, Embase, CINAHL, PsychInfo, ACM Digital Library, IEEExplore, and SCOPUS), covering articles published since 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677902DOI Listing

The Price of Artificial Intelligence.

Authors:
Enrico Coiera

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.

Introduction: Whilst general artificial intelligence (AI) is yet to appear, today's narrow AI is already good enough to transform much of healthcare over the next two decades.

Objective: There is much discussion of the potential benefits of AI in healthcare and this paper reviews the cost that may need to be paid for these benefits, including changes in the way healthcare is practiced, patients are engaged, medical records are created, and work is reimbursed.

Results: Whilst AI will be applied to classic pattern recognition tasks like diagnosis or treatment recommendation, it is likely to be as disruptive to clinical work as it is to care delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677892DOI Listing

Artificial Intelligence in Medicine: Weighing the Accomplishments, Hype, and Promise.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Biomedical Informatics, Columbia University.

Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its "adolescence" at an international meeting in 1991, and as "coming of age" at another meeting in 2007, the AIM field is now more visible and influential than ever before, paralleling the enthusiasm and accomplishments of artificial intelligence (AI) more generally.

Objectives: This article summarizes some of that AIM history, providing an update on the status of the field as it enters its second half-century. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677891DOI Listing

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art - with Reflections on Present AIM Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Computer Science, Rutgers University, USA.

Background: The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970's led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several "winters", as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677895DOI Listing

Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome.

Horm Metab Res 2019 Apr 25;51(4):261-266. Epub 2019 Apr 25.

VKV American Hospital, Women's Healthcare Centre, Istanbul, Turkey.

The purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-0886
Publisher Site
http://dx.doi.org/10.1055/a-0867-0886DOI Listing
April 2019
2 Reads

Characterization of a Novel POU1F1 Mutation Identified on Screening 160 Growth Hormone Deficiency Patients.

Horm Metab Res 2019 Apr 25;51(4):248-255. Epub 2019 Apr 25.

Laboratory of Cyto-Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

The objective of the study is the functional characterization of a novel c.605delC mutation in combined pituitary hormone deficiency (CPHD) and to report the clinical and genetic details of 160 growth hormone deficiency patients. Screening of , , , , and genes by Sanger sequencing was carried out in 160 trios and 100 controls followed by characterization of the c. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-1026
Publisher Site
http://dx.doi.org/10.1055/a-0867-1026DOI Listing
April 2019
1 Read

Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Horm Metab Res 2019 Apr 25;51(4):230-242. Epub 2019 Apr 25.

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0863-5779DOI Listing

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1734-1747

Department of Ophthalmology, University of California, San Francisco, California, United States.

Purpose: Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas is positively associated with clinical levels of corneal neovascularization and fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.18-25961DOI Listing

Transition from video-assisted thoracoscopic to robotic esophagectomy: a single surgeon's experience.

Dis Esophagus 2019 Apr 25. Epub 2019 Apr 25.

Department of Cardiothoracic Surgery, New York University Langone Health, New York, USA.

Lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is a technically challenging part of esophageal cancer surgery, especially after chemoradiotherapy (CRT). Robotic surgery holds promise to increase its safety and feasibility. The aim of this study was to describe a single thoracoscopic surgeon's experience related to the transition from video-assisted esophagectomy (VATE) to robotic esophagectomy (RE)-with a special focus on the safety of left RLN LND. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/dote/doz033DOI Listing

Bio-compatible patient-specific elastic bolus for clinical implementation.

Phys Med Biol 2019 Apr 25. Epub 2019 Apr 25.

Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of).

We investigated two types of materials with very low Shore hardness, silicon rubber (Dragon Skin) and urethane liquid rubber (Clear Flex 30), for use in 3D printing patient-specific boluses. Boluses were 3D printed with these materials using two methods of casting and direct printing. These patient-specific boluses were designed for 3D-printed elaborate human phantoms and their biological, physical, and dosimetric properties were comprehensively assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab1c93DOI Listing

Collagen/β-TCP composite as a bone-graft substitute for posterior spinal fusion in rabbit model: a comparison study.

Biomed Mater 2019 Apr 25. Epub 2019 Apr 25.

Orthopaedics, Xijing Hospital, Xian, Shaanxi, CHINA.

β-TCP bioceramic, as a kind of biocompatible and biodegradable artificial bone scaffolds, is increasingly used to supplement lamina autografts when performing instrumented or non-instrumented spinal fusion, clinically, although solid fusion is not always achieved. The addition of collagen to β-TCP appears to be a potential strategy to improve bone regeneration, thereby enhancing the rate of spinal fusion. This study aimed to compare the fusion in collagen/β-TCP composite, β-TCP and autologous bone in a posterior spinal fusion model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1748-605X/ab1cafDOI Listing

Dependence of LET on material and its impact on current RBE model.

Phys Med Biol 2019 Apr 25. Epub 2019 Apr 25.

Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore, SINGAPORE.

Biological uncertainty remains one of the main sources of uncertainties
 in Proton Therapy, and is encapsulated in a scalar quantity known as Relative
 Biological Eective (RBE). It is currently recognized that a constant RBE of 1.1 is
 not consistent with radiobiological experiment and will lead to sub-optimal clinical
 outcome during treatment planning. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6560/ab1c90
Publisher Site
http://dx.doi.org/10.1088/1361-6560/ab1c90DOI Listing
April 2019
1 Read

Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants.

Authors:
David J Dowling

Immunohorizons 2018 Jul 2;2(6):185-197. Epub 2018 Jul 2.

Division of Infectious Diseases, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115

The need for new adjuvants is absolutely cardinal to the development of new vaccines and to further optimizing current immunization approaches. However, only a few classes of adjuvants are presently incorporated in vaccines approved for human use. Recent advances in the discovery and delivery of TLR agonists as vaccine adjuvants have begun to open up a new toolbox for vaccinologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/immunohorizons.1700063DOI Listing

The DATE Association: A Separate Entity or a Further Extension of the VACTERL Association?

J Surg Res 2019 Apr 22;241:128-134. Epub 2019 Apr 22.

Pediatric Surgery Unit, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy. Electronic address:

Background: The combination of esophageal atresia, congenital duodenal obstruction, and anorectal malformation has seldom been reported. We describe the largest series of patients with such association, which we summed up with the mnemonic acronym DATE [D-duodenal obstruction, A-anorectal malformation (ARM), and TE-tracheoesophageal fistula with esophageal atresia].

Methods: This was a multicenter retrospective review of 13 patients recruited from 8 institutions over a nearly 5-decade period (1968-2017). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804193017
Publisher Site
http://dx.doi.org/10.1016/j.jss.2019.03.054DOI Listing
April 2019
1 Read

Interictal dysphoric disorder of epilepsy: A continuing diagnostic challenge.

Epilepsy Behav 2019 Apr 22;95:34-38. Epub 2019 Apr 22.

Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Poland.

Objective: The interictal dysphoric disorder (IDD) is a proposed epilepsy-specific mood disorder characterized by a cluster of symptoms such as depressed mood, irritability, euphoria, and anxiety. Since its introduction, the concept of IDD has been a matter of debate. This study aimed to evaluate the frequency of the IDD and the association between psychiatric disorders and IDD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.036DOI Listing

The therapeutic effect of stiripentol in Gabrg2 mice associated with epileptic encephalopathy.

Epilepsy Res 2019 Apr 15;154:8-12. Epub 2019 Apr 15.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37232, United States; The Graduate Program of Neuroscience, Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States; Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, United States. Electronic address:

Anti-seizure drugs (ASDs) are widely used and known to increase inhibitory tone on neuro-circuits and reduce aberrant synchronous firing in epilepsy. Some ASDs act as agonist at the GABA receptor. Stiripentol, known to increase GABA receptor activity as well as the metabolites of GABA receptor agonists, is often used in the treatment of an epileptic encephalopathy, Dravet syndrome (DS), which is caused by mutations mainly in SCN1A and in other genes such as GABRG2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.04.006DOI Listing

Dexamethasone ameliorates the damage of hippocampal filamentous actin cytoskeleton but is not sufficient to cease epileptogenesis in pilocarpine induced epileptic mice.

Epilepsy Res 2019 Apr 18;154:26-33. Epub 2019 Apr 18.

Department of Pediatric Neurology, The First Hospital of Jilin University, Changchun, Jilin Province 130021, PR China. Electronic address:

Rogressive deconstruction of filament actin (F-actin) in hippocampal neurons in the epileptic brain have been associated with epileptogenesis. Previous clinical studies suggest that glucocorticoids treatment plays beneficial roles in refractory epilepsy. Glucocorticoids treatment affects dendritic spine morphology by regulating local glucocorticoid receptors and F-actin cytoskeleton dynamics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.04.009DOI Listing

Expression of plasma microRNA-145-5p and its correlation with clinical features in patients with refractory epilepsy.

Epilepsy Res 2019 Apr 19;154:21-25. Epub 2019 Apr 19.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. Electronic address:

Purpose: The potential of microRNAs (miRNAs) as biomarkers has been explored in various brain diseases, including epilepsy. In this study, we are aiming to analyze the aberrant expression of miRNA-145-5p in patients with refractory epilepsy, and to further explore the correlation with clinical features.

Methods: The study cohort comprised 40 patients with refractory epilepsy and 42 healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.04.010DOI Listing

Long-term safety and efficacy of cannabidiol in children and adults with treatmentresistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results.

Epilepsy Res 2019 Mar 25;154:13-20. Epub 2019 Mar 25.

Oishei Children's Hospital, Buffalo, NY, USA.

Background: Since 2014, patients with severe treatment-resistant epilepsies (TREs) have been receiving add-on cannabidiol (CBD) in an ongoing, expanded access program (EAP), which closely reflects clinical practice. We conducted an interim analysis of long-term efficacy and tolerability in patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) who received CBD treatment through December 2016.

Methods: Children and adults with LGS/DS taking stable doses of antiepileptic drugs (AEDs) at baseline were included from 25 EAP sites across the United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.03.015DOI Listing

Jejuno-ileal diverticulitis: A disorder not to underestimate.

Int J Surg Case Rep 2019 Apr 16;58:81-84. Epub 2019 Apr 16.

EOC - Beata Vergine Regional Hospital, Department of Surgery, CH 6850, Mendrisio, Switzerland. Electronic address:

Introduction: Jejuno-ileal diverticulitis is an uncommon, acquired clinical entity, with higher prevalence among patients aged between 60 and 70. The condition is usually silent and has been regarded as relatively innocuous. Sometimes patients complain chronic vague symptoms like malabsorption, pain or nausea, that easily lead to misdiagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2019.04.015DOI Listing

Development and validation of a highly sensitive LC-MS/MS method for in vitro measurement of histamine concentration.

J Pharm Biomed Anal 2019 Apr 12;172:33-41. Epub 2019 Apr 12.

Department of Clinical Pharmacology, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea. Electronic address:

The basophil histamine release test (HRT) is an important in vitro diagnostic assay to evaluate immunoglobin E (IgE)-mediated allergic responses. In this study, a bioanalytical LC-MS/MS method was developed and validated to quantify histamine in the leukocyte suspension from human peripheral blood. The method used pre-column derivatization with phenylisothiocyanate (PITC) and the resulting phenylthiocarbamyl (PTC) histamine was analyzed by positive-ion electrospray ionization using the multiple reaction monitoring mode. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.04.025DOI Listing

Quantitation of paclitaxel, and its 6-alpha-OH and 3-para-OH metabolites in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2019 Apr 15;172:26-32. Epub 2019 Apr 15.

Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, United States; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

We have developed a high performance liquid chromatography mass spectrometry method for quantitating paclitaxel and its 6-alpha-OH and 3-para-OH metabolites in 0.1 mL human plasma. After MTBE liquid-liquid extraction, chromatographic separation was achieved with a Phenomenex synergy polar reverse phase (4 μm, 2 mm × 50 mm) column and a gradient of 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07317085183240
Publisher Site
http://dx.doi.org/10.1016/j.jpba.2019.04.027DOI Listing
April 2019
1 Read

Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis.

Mol Ther Nucleic Acids 2019 Apr 6;16:407-418. Epub 2019 Apr 6.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China; Shanghai Municipal Key Clinical Speciality, Shanghai 20030, China. Electronic address:

Premature ovarian failure (POF) is one of the most common complications among female patients with tumors treated with chemotherapy and requires advanced treatment strategies. Human amniotic epithelial cell (hAEC)-based therapy mediates tissue regeneration in a variety of diseases, and increasing evidence suggests that the therapeutic efficacy of hAECs mainly depends on paracrine action. This study aimed to identify exosomes derived from hAECs and explored the therapeutic potential in ovaries damaged by chemotherapy and the underlying molecular mechanism. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
Publisher Site
http://dx.doi.org/10.1016/j.omtn.2019.03.008DOI Listing
April 2019
1 Read

Pediatric use of Pericapsular Nerve Group (PENG) block for hip surgical procedures.

J Clin Anesth 2019 Apr 22;57:143-144. Epub 2019 Apr 22.

Department of Epidemiology and Clinical Research, Clínica del Campestre, Medellín, Colombia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinane.2019.04.010DOI Listing

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Apr 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
Publisher Site
http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
April 2019
1 Read

Sjogren's syndrome: An update on disease pathogenesis, clinical manifestations and treatment.

Clin Immunol 2019 Apr 22. Epub 2019 Apr 22.

Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, 100 High Street, Buffalo, NY 14203, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.04.009DOI Listing

Capsaicin and gingerol analogues inhibit the growth of efflux-multidrug resistant bacteria and R-plasmids conjugal transfer.

J Ethnopharmacol 2019 Apr 22:111871. Epub 2019 Apr 22.

Research Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, UK. Electronic address:

Ethnopharmacological Importance: Capsicum and ginger are used widely in human diets and in folklore medicines. Chemically, gingerol is a relative of capsaicin and both classes of compounds are notable for their spiciness and characteristic pungent aroma. Previous studies have demonstrated that these compounds contain antimicrobial compounds with robust pharmacological importance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111871DOI Listing

Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD.

Adv Med Sci 2019 Apr 22;64(2):344-348. Epub 2019 Apr 22.

Department of Pneumology and Allergy, Medical University of Lodz, Lodz, Poland.

Purpose: Chronic obstructive pulmonary disease is the most common chronic lung disease, which may be caused by different pathological processes, including inflammation. Furthermore, signs of changes in thyroid hormone levels are found in some patients. Deiodinases (DIOs) are selenoproteins (enzymes) involved in the synthesis of thyroid hormones. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18961126183021
Publisher Site
http://dx.doi.org/10.1016/j.advms.2019.04.001DOI Listing
April 2019
1 Read

Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells.

Adv Med Sci 2019 Apr 22;64(2):338-343. Epub 2019 Apr 22.

Department of Immunology and Allergy, Chair of Clinical Immunology and Rheumatology, Medical University of Lodz, Lodz, Poland. Electronic address:

Purpose: Respiratory viral infection and nonsteroidal anti-inflammatory drugs (NSAIDs) may affect arachidonic acid (AA) metabolism in the airway epithelium, however their joint effect has not been studied. We hypothesized, that alternations of AA metabolism in human airway epithelial cells (ECs) - induced by Parainfluenza virus type 3 (PIV3) - may be modified by concomitant treatment with NSAIDs.

Materials And Methods: Nasal (RPMI 2650) and bronchial (BEAS-2B) epithelial cells were cultured into confluence and then infected with PIV3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.advms.2019.04.004DOI Listing

The cell in the ink: Improving biofabrication by printing stem cells for skeletal regenerative medicine.

Biomaterials 2019 Apr 14;209:10-24. Epub 2019 Apr 14.

Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address:

Recent advances in regenerative medicine have confirmed the potential to manufacture viable and effective tissue engineering 3D constructs comprising living cells for tissue repair and augmentation. Cell printing has shown promising potential in cell patterning in a number of studies enabling stem cells to be precisely deposited as a blueprint for tissue regeneration guidance. Such manufacturing techniques, however, face a number of challenges including; (i) post-printing cell damage, (ii) proliferation impairment and, (iii) poor or excessive final cell density deposition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.04.009DOI Listing

Localized delivery of immunosuppressive regulatory T cells to peripheral nerve allografts promotes regeneration of branched segmental defects.

Biomaterials 2019 Apr 17;209:1-9. Epub 2019 Apr 17.

University of Wyoming, School of Pharmacy, Laramie, WY, 82071, USA. Electronic address:

Segmental injuries to peripheral nerves (PNs) too often result in lifelong disability or pain syndromes due to a lack of restorative treatment options. For injuries beyond a critical size, a bridging device must be inserted to direct regeneration. PN allografts from immunologically incompatible donors are highly effective bridging devices but are not a regular clinical option because of the expense and health risks of systemic immunosuppression (ISN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.04.015DOI Listing

Antimicrobial Polymer Modifications to Reduce Microbial Bioburden on Endotracheal Tubes and Ventilator Associated Pneumonia.

Acta Biomater 2019 Apr 22. Epub 2019 Apr 22.

Department of Materials Science & Engineering, University of Central Florida, Orlando, FL, United States. Electronic address:

Hospital associated infections (HAIs), infections acquired by patients during care in a hospital, remain a prevalent issue in the healthcare field. These infections often occur with the use of indwelling medical devices such as endotracheal tubes (ETTs) that can result in ventilator-associated pneumonia (VAP). When examining the various routes of infection, VAP is associated with the highest incidence, rate of morbidity, and economic burden. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17427061193028
Publisher Site
http://dx.doi.org/10.1016/j.actbio.2019.04.042DOI Listing
April 2019
1 Read

Wild owls colonized by international clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli and Salmonella Infantis in the Southern Cone of America.

Sci Total Environ 2019 Apr 13;674:554-562. Epub 2019 Apr 13.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil. Electronic address:

Extended-spectrum β-lactamases (ESBLs)-producing Enterobacteriaceae have been classified as critical priority pathogens by the World Health Organization (WHO). We have conducted a microbiological and genomic surveillance study, in order to investigate the occurrence and features of antibiotic-resistant bacteria in wild birds admitted to a wildlife rescue and rehabilitation centre in Chile. This study reports for the first time the occurrence of highly virulent ESBL-producing Escherichia coli and Salmonella enterica serovar Infantis in wild owls inhabiting the Southern Cone of America. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.04.149DOI Listing

Natural products in Licorice for the therapy of liver diseases: Progress and future opportunities.

Pharmacol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology and Immunology, Virginia Commonwealth University, 1217 E Marshall St. KMSB, Richmond, VA 23298, USA; School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Beisanhuandonglu road, Beijing 100029, China. Electronic address:

Liver diseases related complications represent a significant source of morbidity and mortality worldwide, creating a substantial economic burden. Oxidative stress, excessive inflammation, and dysregulated energy metabolism significantly contributed to liver diseases. Therefore, discovery of novel therapeutic drugs for the treatment of liver diseases are urgently required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2019.04.025DOI Listing

A systematic review and network meta-analysis comparing treatments for faecal incontinence.

Int J Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Colorectal Surgery, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK; Department of Surgery and Cancer, Imperial College, London, UK.

Background: Although numerous treatments exist for fecal incontinence (FI), no consensus exists on the best treatment strategy. The aim was to review the literature and to compare the clinical outcomes and effectiveness of treatments available for FI.

Materials And Method: A systematic literature review was performed, from inception to May 2018, of the following databases: MEDLINE, EMBASE, Science Citation Index Expanded, Cochrane Library. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijsu.2019.04.007DOI Listing

Assessing spatial concordance between theranostic pairs using phantom and patient specific acceptance criteria: Application to Tc-MAA SPECT/Y-microsphere PET.

Int J Radiat Oncol Biol Phys 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.

Purpose: Predictive 3D dosimetry requires spatial concordance between diagnostic and therapeutic activity distributions. We assess similarity between theranostic pairs (Tc-MAA SPECT/ Y microsphere PET) in patients using criteria that account for spatial resolution differences and mis-registration.

Methods: Phantom-based acceptance criteria were determined using a liver phantom filled with Tc and YCl scanned with SPECT/CT and PET/CT, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijrobp.2019.04.012DOI Listing

Hot melt extrusion of heat-sensitive and high melting point drug: Inhibit the recrystallization of the prepared amorphous drug during extrusion to improve the bioavailability.

Int J Pharm 2019 Apr 22. Epub 2019 Apr 22.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:

Using tadalafil (TD) as a representative of heat-sensitive drug with high melting point and strong crystallization tendency, we observed that recrystallization of the prepared amorphous materials during extrusion can result in failure of amorphous solid dispersion (ASD) extrusion. Such recrystallization process of amorphous TD during reheating process was investigated systematically. Our results show that spray-dried amorphous TD sample is more prone to recrystallize (occurs from 150°C) in comparison to the melt-quenched amorphous TD sample (recrystallizes from 190°C). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.04.064DOI Listing

HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator.

Toxicol Appl Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China. Electronic address:

As a central regulator for endoplasmic reticulum (ER) stress, glucose-regulated protein 78 (GRP78), controls the activation of ER-transmembrane signaling mechanisms by inducing unfolded protein response (UPR) in response to ER stress. Although limited glucose availability often occurs in poorly vascularized solid cancers, cancer cells often initiate the UPR to support cellular homeostasis and survival under stress conditions. Therefore, targeting GRP78 expression and UPR pathway activation may provide a new strategy for anticancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2019.04.017DOI Listing

Bioinformatics analysis of EgA31 and EgG1Y162 proteins for designing a multi-epitope vaccine against Echinococcus granulosus.

Infect Genet Evol 2019 Apr 22. Epub 2019 Apr 22.

State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, PR China; College of Basic Medicine of Xinjiang Medical University, Urumqi 830011, Xinjiang, PR China. Electronic address:

Cystic echinococcosis (CE) is a global zoonosis caused by the larvae of the parasite Echinococcus granulosus (E. granulosus). According to its life cycle and previous studies of antigen candidates for vaccines against E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2019.04.017DOI Listing

Grading and baseline characteristics of meibomian glands in meibography images and their clinical associations in the Dry Eye Assessment and Management (DREAM) study.

Ocul Surf 2019 Apr 22. Epub 2019 Apr 22.

Hamilton Eye Institute, University of Tennessee Health Science Center (UTHSC), Memphis, TN, USA.

Purpose: To describe and evaluate a comprehensive grading system for meibomian gland (MG) digital infrared images developed by for the Dry Eye Assessment and Management (DREAM) Study.

Methods: Cross-sectional study. Reading Center (RC) certified readers independently evaluated MG features of both lids from meibographs of dry eye disease subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2019.04.003DOI Listing

Association of high-fat diet with neuroinflammation, anxiety-like defensive behavioral responses, and altered thermoregulatory responses in male rats.

Brain Behav Immun 2019 Apr 22. Epub 2019 Apr 22.

Department of Biological Science, Laboratory of Cardiovascular Physiology, Federal University of Ouro Preto, Ouro Preto, MG 35400-000, Brazil. Electronic address:

Overweight and obesity are a worldwide pandemic affecting billions of people. These conditions have been associated with a chronic low-grade inflammatory state that is recognized as a risk factor for a range of somatic diseases as well as neurodevelopmental disorders, anxiety disorders, trauma- and stressor-related disorders, and affective disorders. We previously reported that the ingestion of a high-fat diet (HFD; 45% fat kcal/g) for nine weeks was capable of inducing obesity in rats in association with increased reactivity to stress and increased anxiety-related defensive behavior. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08891591193013
Publisher Site
http://dx.doi.org/10.1016/j.bbi.2019.04.030DOI Listing
April 2019
1 Read

Raman Spectroscopy identifies differences in ochronotic and non-ochronotic cartilage; a potential novel technique for monitoring ochronosis.

Osteoarthritis Cartilage 2019 Apr 22. Epub 2019 Apr 22.

Lancaster Medical School, Faculty of Health & Medicine, Lancaster University, Bailrigg, Lancaster, UK. Electronic address:

Objective: Alkaptonuria (AKU) is a rare, inherited disorder of tyrosine metabolism, where patients are unable to breakdown homogentisic acid (HGA), which increases systemically over time. It presents with a clinical triad of features; HGA in urine, ochronosis of collagenous tissues, and the subsequent ochronotic arthritis of these tissues. In recent years the advance in the understanding of the disease and the potential treatment of the disorder looks promising with the data on the efficacy of nitisinone. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10634584193095
Publisher Site
http://dx.doi.org/10.1016/j.joca.2019.04.012DOI Listing
April 2019
1 Read
  • Page 1 of 88341