516 results match your criteria Clinical Utility of Evoked Potentials


VEP estimation of visual acuity: a systematic review.

Doc Ophthalmol 2020 Jun 2. Epub 2020 Jun 2.

The Department of Clinical and Academic Ophthalmology, Great Ormond Street Hospital for Children, London, UK.

Purpose: Visual evoked potentials (VEPs) can be used to measure visual resolution via a spatial frequency (SF) limit as an objective estimate of visual acuity. The aim of this systematic review is to collate descriptions of the VEP SF limit in humans, healthy and disordered, and to assess how accurately and precisely VEP SF limits reflect visual acuity.

Methods: The protocol methodology followed the PRISMA statement. Read More

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http://dx.doi.org/10.1007/s10633-020-09770-3DOI Listing

Neurophysiological monitoring of spinal cord function during spinal deformity surgery: 2020 SRS neuromonitoring information statement.

Spine Deform 2020 May 25. Epub 2020 May 25.

Radboud University Medical Center, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.

The Scoliosis Research Society has developed an updated information statement on intraoperative neurophysiological monitoring of spinal cord function during spinal deformity surgery. The statement reviews the risks of spinal cord compromise associated with spinal deformity surgery; the statement then discusses the various modalities that are available to monitor the spinal cord, including somatosensory-evoked potentials, motor-evoked potentials, and electromyographic (EMG) options. Anesthesia considerations, the importance of a thoughtful team approach to successful monitoring, and the utility of checklists are also discussed. Read More

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http://dx.doi.org/10.1007/s43390-020-00140-2DOI Listing

Pearls and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part I.

Neurol Sci 2020 May 9. Epub 2020 May 9.

Neurology Ward Unit, Bambino Gesù Hospital, Rome, Italy.

Event-related potentials (ERPs) are obtained from the electroencephalogram (EEG) or the magnetoencephalogram (MEG, event-related fields (ERF)), extracting the activity that is time-locked to an event. Despite the potential utility of ERP/ERF in cognitive domain, the clinical standardization of their use is presently undefined for most of procedures. The aim of the present review is to establish limits and reliability of ERP medical application, summarize main methodological issues, and present evidence of clinical application and future improvement. Read More

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http://dx.doi.org/10.1007/s10072-020-04420-7DOI Listing

The FAST graph: A novel framework for the anatomically-guided visualization and analysis of cortico-cortical evoked potentials.

Epilepsy Res 2020 Mar 9;161:106264. Epub 2020 Jan 9.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Background: Intracerebral electroencephalography (iEEG) using stereoelectroencephalography (SEEG) methodology for epilepsy surgery gives rise to complex data sets. The neurophysiological data obtained during the in-patient period includes categorization of the evoked potentials resulting from direct electrical cortical stimulation such as cortico-cortical evoked potentials (CCEPs). These potentials are recorded by hundreds of contacts, making these waveforms difficult to quickly interpret over such high-density arrays that are organized in three dimensional fashion. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206791PMC

Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis.

Neuromodulation 2020 Feb 5. Epub 2020 Feb 5.

Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

Introduction: The P50, a positive auditory-evoked potential occurring 50 msec after an auditory click, has been characterized extensively with electroencephalography (EEG) to detect aberrant auditory electrophysiology in disorders like schizophrenia (SZ) where 61-74% have an auditory gating deficit. The P50 response occurs in primary auditory cortex and several thalamocortical regions. In rodents, the gated P50 response has been identified in the reticular thalamic nucleus (RT)-a deep brain structure traversed during deep brain stimulation (DBS) targeting of the ventral intermediate nucleus (VIM) of the thalamus to treat essential tremor (ET) allowing for interspecies comparison. Read More

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http://dx.doi.org/10.1111/ner.13101DOI Listing
February 2020

Utility of intraoperative electromyography in placing C7 pedicle screws.

J Neurosurg Spine 2020 Jan 31:1-9. Epub 2020 Jan 31.

1Department of Neurosurgery, Mount Sinai Health System, New York, New York; and.

Objective: The C7 vertebral body is morphometrically unique; it represents the transition from the subaxial cervical spine to the upper thoracic spine. It has larger pedicles but relatively small lateral masses compared to other levels of the subaxial cervical spine. Although the biomechanical properties of C7 pedicle screws are superior to those of lateral mass screws, they are rarely placed due to increased risk of neurological injury. Read More

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http://dx.doi.org/10.3171/2019.11.SPINE191120DOI Listing
January 2020

Persistent postural-perceptual dizziness: Clinical and neurophysiological study.

J Clin Neurosci 2020 Feb 14;72:26-30. Epub 2020 Jan 14.

University Hospital Center Zagreb, Department of Neurology, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.

The aim of this study was to evaluate clinical and neurophysiological characteristics of Persistent postural-perceptual dizziness (PPPD) in a tertiary vertigo clinic. This was a cross-sectional study that included consecutive patients examined in the Vertigo clinic of the University Hospital Center Zagreb, Croatia. The following data were extracted from the electronic hospital records: age, sex, the duration of symptoms, initial trigger event, results of the caloric testing, video head impulse test (vHIT) for all six semicircular canals and ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP). Read More

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http://dx.doi.org/10.1016/j.jocn.2020.01.043DOI Listing
February 2020
1.318 Impact Factor

Integrated In-Ear Device for Auditory Health Assessment.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:56-59

Clinical assessment of the human auditory system is an integral part of evaluating the health of a patient's cognitive processes. Conventional tests performed by audiologists include the Auditory Steady State Response (ASSR) and the Auditory Brainstem Response (ABR), both of which present an audio stimulus to the patient in order to elicit a change in brain state measurable by electroencephalography (EEG) techniques. Spatial monitoring of the electrophysiological activity in the auditory cortex, temporal cortex, and brain stem during auditory stimulus evaluation can be used to pinpoint to location of auditory dysfunction along the auditory pathway. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856455DOI Listing

Somatosensory Evoked Potentials and Neuroprognostication After Cardiac Arrest.

Neurocrit Care 2020 Jan 6. Epub 2020 Jan 6.

Department of Neurosurgery, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building 823, Baltimore, MD, 21201, USA.

Improved understanding of post-cardiac arrest syndrome and clinical practices such as targeted temperature management have led to improved mortality in this cohort. Attention has now been placed on development of tools to aid in predicting functional outcome in comatose cardiac arrest survivors. Current practice uses a multimodal approach including physical examination, neuroimaging, and electrophysiologic data, with a primary utility in predicting poor functional outcome. Read More

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http://dx.doi.org/10.1007/s12028-019-00903-4DOI Listing
January 2020

A new parameter to discriminate amyotrophic lateral sclerosis patients from healthy participants by motor cortical excitability changes.

Muscle Nerve 2020 03 20;61(3):354-362. Epub 2020 Jan 20.

Department of Neurology, Clinical Neurophysiology Division, Gazi University Faculty of Medicine, Ankara, Turkey.

Introduction: We sought a combination of abnormalities to define a more sensitive measure of cortical excitability in amyotrophic lateral sclerosis (ALS).

Methods: The automatic threshold tracking method was employed to assess the resting motor threshold, intracortical facilitation (ICF), short-interval intracortical inhibition (SICI), and short-interval intracortical faciilitation (SICF) in patients and controls.

Results: SICF at interstimulus intervals (ISI) between 1 and 1. Read More

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http://dx.doi.org/10.1002/mus.26786DOI Listing

Utility and practice of electrodiagnostic testing in the pediatric population: An AANEM consensus statement.

Muscle Nerve 2020 02;61(2):143-155

Centre de Référence Maladies Neuromusculaires, Service de Neurologie, Réanimation et Réeducation Pédiatriques, Hôpital Raymond Poincaré, Garches, France.

Nerve conduction studies and needle electromyography, collectively known as electrodiagnostic (EDX) studies, have been available for pediatric patients for decades, but the accessibility of this diagnostic modality and the approach to testing vary significantly depending on the physician and institution. The maturation of molecular diagnostic approaches and other diagnostic technologies such as neuromuscular ultrasound indicate that an analysis of current needs and practices for EDX studies in the pediatric population is warranted. The American Association of Neuromuscular & Electrodiagnostic Medicine convened a consensus panel to perform literature searches, share collective experiences, and develop a consensus statement. Read More

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http://dx.doi.org/10.1002/mus.26752DOI Listing
February 2020

Motor Evoked Potentials in Hereditary Spastic Paraplegia-A Systematic Review.

Front Neurol 2019 18;10:967. Epub 2019 Sep 18.

Department of Neurogenetics, Kolling Institute, Royal North Shore Hospital, St Leonards, NSW, Australia.

Hereditary Spastic Paraplegia (HSP) is a slowly progressive neurodegenerative disorder with no disease modifying treatment. Potential therapeutic approaches are emerging and large-scale clinical drug trials for patients with HSP are imminent. A sensitive biomarker to measure the drug efficacy in these trials is required. Read More

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http://dx.doi.org/10.3389/fneur.2019.00967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759520PMC
September 2019
1 Read

The Utility of Preoperative Neuromonitoring for Adolescent Idiopathic Scoliosis.

Int J Spine Surg 2019 Aug 31;13(4):317-320. Epub 2019 Aug 31.

Department of Orthopaedics, The Ohio State University, Columbus, Ohio.

Background: Intraoperative neuromonitoring is well established and widely used to assist in completing corrective surgery for adolescent idiopathic scoliosis (AIS) safely. The role of preoperative measurement of somatosensory evoked potentials (SSEPs) and/or transcranial magnetic stimulation (TMS) to determine if there is transpinal pathology, however, is not clear. We sought to determine if preoperative SSEP and/or TMS measurement provided clinical benefit to patients with AIS. Read More

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http://dx.doi.org/10.14444/6043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724753PMC
August 2019
5 Reads

Serial Visual Evoked Potentials in Patients with Craniosynostosis and Invasive Intracranial Pressure Monitoring.

Plast Reconstr Surg 2019 09;144(3):446e-452e

Pittsburgh, Pa.; and Sohag, Egypt From the Department of Plastic Surgery, Cleft-Craniofacial Center, the Department of Ophthalmology, UPMC Eye Center, and the Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center; and the Plastic Surgery Department, Cleft and Craniofacial Unit, Sohag University Hospital.

This study aimed to detect the ability of pattern visual evoked potentials to detect visual pathway dysfunction in a cohort of patients with craniosynostosis who also had invasive intracranial pressure measurement. A retrospective review was conducted on craniosynostosis patients who had invasive intracranial pressure measurement and at least one pattern visual evoked potentials test. Reversal pattern visual evoked potentials were performed with both eyes open. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005935DOI Listing
September 2019
9 Reads
2.993 Impact Factor

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve.

Nat Biomed Eng 2020 02 19;4(2):181-194. Epub 2019 Aug 19.

Medtronic Chair in Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École polytechnique fédérale de Lausanne, Geneva, Switzerland.

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve as tools for studying the visual system. Optic-nerve stimulation is particularly promising because it directly activates nerve fibres, takes advantage of the high-level information processing occurring downstream in the visual pathway, does not require optical transparency and could be effective in cases of eye trauma. Read More

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http://dx.doi.org/10.1038/s41551-019-0446-8DOI Listing
February 2020

Between-ear sound frequency disparity modulates a brain stem biomarker of binaural hearing.

J Neurophysiol 2019 09 17;122(3):1110-1122. Epub 2019 Jul 17.

Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.

The auditory brain stem response (ABR) is an evoked potential that indexes a cascade of neural events elicited by sound. In the present study we evaluated the influence of sound frequency on a derived component of the ABR known as the binaural interaction component (BIC). Specifically, we evaluated the effect of acoustic interaural (between-ear) frequency mismatch on BIC amplitude. Read More

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http://dx.doi.org/10.1152/jn.00057.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766741PMC
September 2019
3 Reads

Clinical Utility of Oculomotor and Electrophysiological Measures in Identifying Concussion History.

Clin J Sport Med 2019 07;29(4):292-297

Center for Brain, Biology, and Behavior, University of Nebraska-Lincoln, Lincoln, Nebraska.

Objective: To examine whether oculomotor and electrophysiological measures improve the clinical performance of the typical concussion protocol for classifying collegiate athletes with a history of concussion.

Design: Cross-sectional.

Setting: University Athletic Medicine and Research Facility. Read More

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http://dx.doi.org/10.1097/JSM.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893446PMC
July 2019
8 Reads

Superconditioning TMS for examining upper motor neuron function in MND.

Exp Brain Res 2019 Aug 7;237(8):2087-2103. Epub 2019 Jun 7.

Department of Neurosurgery, Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA.

We used transcranial magnetic stimulation (TMS) of motor cortex, including a novel four-pulse superconditioning (TMSsc) paradigm, in repeated examinations of motor-evoked potentials (MEPs) in eight subjects with motor neuron disease (MND), including seven with amyotrophic lateral sclerosis (ALS). The goals were: (1) to look for evidence of cortical hyperexcitability, including a reduction in short-interval intracortical inhibition (SICI); and (2) to examine the utility of using TMSsc for quantifying upper motor neuron function during MND progression. Testing of abductor pollicis brevis (APB) and tibialis anterior (TA) muscles bilaterally was carried out every 3 months in MND subjects for up to 2 years; results were compared to those from a cohort of 15 control subjects. Read More

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http://link.springer.com/10.1007/s00221-019-05573-4
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http://dx.doi.org/10.1007/s00221-019-05573-4DOI Listing
August 2019
7 Reads
2.036 Impact Factor

Test-Retest Reliability of the Effects of Continuous Theta-Burst Stimulation.

Front Neurosci 2019 17;13:447. Epub 2019 May 17.

Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

Objectives: The utility of continuous theta-burst stimulation (cTBS) as index of cortical plasticity is limited by inadequate characterization of its test-retest reliability. We thus evaluated the reliability of cTBS aftereffects, and explored the roles of age and common single-nucleotide polymorphisms in the brain-derived neurotrophic factor () and apolipoprotein E () genes.

Methods: Twenty-eight healthy adults (age range 21-65) underwent two identical cTBS sessions (median interval = 9. Read More

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http://dx.doi.org/10.3389/fnins.2019.00447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533847PMC
May 2019
5 Reads

The role of stimulus-driven versus goal-directed processes in fight and flight tendencies measured with motor evoked potentials induced by Transcranial Magnetic Stimulation.

PLoS One 2019 20;14(5):e0217266. Epub 2019 May 20.

Department of Experimental Psychology, Ghent University, Ghent, Belgium.

This study examines two contrasting explanations for early tendencies to fight and flee. According to a stimulus-driven explanation, goal-incompatible stimuli that are easy/difficult to control lead to the tendency to fight/flee. According to a goal-directed explanation, on the other hand, the tendency to fight/flee occurs when the expected utility of fighting/fleeing is the highest. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527228PMC
February 2020
5 Reads

A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder.

J Autism Dev Disord 2019 Aug;49(8):3181-3190

Department of Linguistics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5-20 Hz band during 0.2-1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. Read More

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http://dx.doi.org/10.1007/s10803-019-04040-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625831PMC
August 2019
2 Reads

The Utility of Event-Related Potentials in Clinical Psychology.

Annu Rev Clin Psychol 2019 05;15:71-95

Department of Psychology, Florida State University, Tallahassee, Florida 32306, USA.

Event-related potentials (ERPs) are direct measures of brain activity that can be leveraged for clinically meaningful research. They can relate robustly both to continuous measures of individual difference and to categorical diagnoses in ways that clarify similarities and distinctions between apparently related disorders and traits. ERPs can be linked to genetic risk, can act as moderators of developmental trajectories and responses to stress, and can be leveraged to identify those at greater risk for psychopathology, especially when used in combination with other neural and self-report measures. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095457DOI Listing
May 2019
4 Reads

Machine Learning Approaches to Analyze Speech-Evoked Neurophysiological Responses.

J Speech Lang Hear Res 2019 03;62(3):587-601

Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh.

Purpose Speech-evoked neurophysiological responses are often collected to answer clinically and theoretically driven questions concerning speech and language processing. Here, we highlight the practical application of machine learning (ML)-based approaches to analyzing speech-evoked neurophysiological responses. Method Two categories of ML-based approaches are introduced: decoding models, which generate a speech stimulus output using the features from the neurophysiological responses, and encoding models, which use speech stimulus features to predict neurophysiological responses. Read More

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http://pubs.asha.org/doi/10.1044/2018_JSLHR-S-ASTM-18-0244
Publisher Site
http://dx.doi.org/10.1044/2018_JSLHR-S-ASTM-18-0244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802895PMC
March 2019
13 Reads

Transorbital ultrasonography in acute optic neuritis: Can it be a supportive diagnostic tool?

Mult Scler Relat Disord 2019 Jun 25;31:54-58. Epub 2019 Mar 25.

Department of Neurology, Korea University Medical Center, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address:

Background: Because of limitations of conventional tools for diagnosing optic neuritis (ON), transorbital ultrasonography (TOUS) was introduced as a promising tool to evaluate the optic nerve. However, studies demonstrating its utility are scarce.

Objective: To assess the practical diagnostic value of TOUS in patients with ON along with other diagnostic tools such as visual evoked potential (VEP), MRI, and optical coherence tomography (OCT). Read More

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http://dx.doi.org/10.1016/j.msard.2019.03.015DOI Listing

Neurophysiological Monitoring During Arteriovenous Malformation Embolization.

Oper Neurosurg (Hagerstown) 2019 11;17(5):503-508

Department of Neurosurgery, Penn State Health, Hershey, Pennsylvania.

Background: Neurophysiological monitoring (NPM) is frequently performed during arteriovenous malformation (AVM) embolization. However, the ability of NPM to predict neurological deficits or improve surgical decision making in this setting has not been studied.

Objective: To review our use of NPM during AVM embolization to better define its utility. Read More

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http://dx.doi.org/10.1093/ons/opz028DOI Listing
November 2019
7 Reads

Awake craniotomy with transcortical motor evoked potential monitoring for resection of gliomas in the precentral gyrus: utility for predicting motor function.

J Neurosurg 2019 Mar 15:1-11. Epub 2019 Mar 15.

1Department of Neurosurgery.

OBJECTIVEResection of gliomas in the precentral gyrus carries a risk of severe motor dysfunction. To prevent permanent, severe postoperative motor dysfunction, reliable intraoperative predictors of postoperative function are required. Since 2005, the authors have removed gliomas in the precentral gyrus with combined functional mapping and estimation of intraoperative voluntary movement (IVM) during awake craniotomy and transcortical motor evoked potentials (MEPs). Read More

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http://dx.doi.org/10.3171/2018.11.JNS182609DOI Listing
March 2019
4 Reads

Vestibular evoked myogenic potentials and their clinical utility in patients with amyotrophic lateral sclerosis.

Clin Neurophysiol 2019 05 21;130(5):647-654. Epub 2019 Feb 21.

Department of Neurology, Peking University Third Hospital, Beijing, China; Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking University, Beijing, China. Electronic address:

Objective: To evaluate the diagnostic value of vestibular evoked myogenic potentials (VEMPs) in the assessment of brainstem function integrity in patients with amyotrophic lateral sclerosis (ALS).

Methods: This was a prospective case-control study including 30 definite or probable ALS patients divided into two groups (with or without brainstem involvement) and 30 healthy controls. Cervical (c-), masseter (m-) and ocular VEMP (o-VEMP) measurements were obtained for all the participants. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.023DOI Listing
May 2019
9 Reads

Transcranial magnetic stimulation in subjects with phantom pain and non-painful phantom sensations: A systematic review.

Brain Res Bull 2019 05 9;148:1-9. Epub 2019 Mar 9.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany.

Several studies have applied transcranial magnetic stimulation (TMS) in the attempt to further explore the pathophysiological mechanisms of phantom-limb pain (PLP) and non-painful phantom sensations (PS). We performed a systematic review of available evidence of this emerging technology in this indication. We identified studies which report a reduced intracortical inhibition and increased intracortical facilitation in the hemisphere contralateral to the PLP. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.001DOI Listing
May 2019
3 Reads
2.718 Impact Factor

On the reflex mechanisms of cervical transcutaneous spinal cord stimulation in human subjects.

J Neurophysiol 2019 05 6;121(5):1672-1679. Epub 2019 Mar 6.

Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo , Tokyo , Japan.

Transcutaneous and epidural electrical spinal cord stimulation techniques are becoming more valuable as electrophysiological and clinical tools. Recently, remarkable recovery of the upper limb sensorimotor function during cervical spinal stimulation was demonstrated. In the present study, we sought to elucidate the neural mechanisms underlying the effects of transcutaneous spinal cord stimulation (tSCS) of the cervical spine. Read More

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https://www.physiology.org/doi/10.1152/jn.00802.2018
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http://dx.doi.org/10.1152/jn.00802.2018DOI Listing
May 2019
4 Reads

The erring brain: Error-related negativity as an endophenotype for OCD-A review and meta-analysis.

Authors:
Anja Riesel

Psychophysiology 2019 04;56(4):e13348

Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

Obsessive-compulsive disorder (OCD) is a complex and heterogeneous disorder that is associated with high personal and societal costs. Feelings of doubt, worry, and repetitive behavior, key symptoms of OCD, have been linked to hyperactive error signals in the brain. The error-related negativity (ERN) represents a validated marker of error processing in the ERP. Read More

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http://dx.doi.org/10.1111/psyp.13348DOI Listing
April 2019
1 Read

Diagnostic and therapeutic values of intraoperative electrophysiological neuromonitoring during resection of intradural extramedullary spinal tumors: a single-center retrospective cohort and meta-analysis.

J Neurosurg Spine 2019 Mar 1:1-11. Epub 2019 Mar 1.

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

OBJECTIVEWith the advent of intraoperative electrophysiological neuromonitoring (IONM), surgical outcomes of various neurosurgical pathologies, such as brain tumors and spinal deformities, have improved. However, its diagnostic and therapeutic value in resecting intradural extramedullary (ID-EM) spinal tumors has not been well documented in the literature. The objective of this study was to summarize the clinical results of IONM in patients with ID-EM spinal tumors. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181095DOI Listing
March 2019
11 Reads

Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: A review.

Int J Psychophysiol 2019 11 1;145:5-14. Epub 2019 Mar 1.

Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan. Electronic address:

Mismatch negativity (MMN) reduction is one of the most robust findings among several neurophysiological and neurocognitive measures in patients with schizophrenia. MMN is a promising biomarker for schizophrenia because of the following properties: 1) its relationship with early psychosis, including clinical high-risk (CHR); 2) its relationship with the functional abilities of patients; and 3) its translatability into basic research using animal models. Specifically, the utility of the passive auditory oddball paradigm that does not require subjects to make behavioral responses enables identical physiological activities to be obtained from both experimental animals and patients. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.02.009DOI Listing
November 2019
14 Reads

Multicenter, Randomized, Double-Blind Study Protocol Using Human Spinal Cord Recording Comparing Safety, Efficacy, and Neurophysiological Responses Between Patients Being Treated With Evoked Compound Action Potential-Controlled Closed-Loop Spinal Cord Stimulation or Open-Loop Spinal Cord Stimulation (the Evoke Study).

Neuromodulation 2019 Apr 3;22(3):317-326. Epub 2019 Mar 3.

Department of Pain Management, Cleveland Clinic, Cleveland, OH, USA.

Background: The spinal cord (SC) response to stimulation has yet to be studied in a pivotal clinical study. We report the study design of an ongoing multicenter, randomized, double-blind, controlled, parallel-arm study of an evoked compound action potential (ECAP) controlled closed-loop spinal cord stimulation (SCS) system, which aims to gain U.S. Read More

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http://dx.doi.org/10.1111/ner.12932DOI Listing
April 2019
28 Reads

Clinical utility and prospective of TMS-EEG.

Clin Neurophysiol 2019 05 19;130(5):802-844. Epub 2019 Jan 19.

Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, enabling the characterization and development of potential TMS-EEG predictors and markers of treatments and of the pathophysiology of brain disorders. The objective of this article is to present a comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.001DOI Listing
May 2019
31 Reads
3.097 Impact Factor

Amyotrophic lateral sclerosis diagnostic index: Toward a personalized diagnosis of ALS.

Neurology 2019 02 11;92(6):e536-e547. Epub 2019 Jan 11.

From Westmead Clinical School (N.G., P.M., M.v.d.B., S.V.), Brain and Mind Center (J.H., K.S., J.M.M., S.B.P., M.C.K.), and NHMRC Clinical Trials Centre (K.B.), University of Sydney; and Westmead Hospital (K.B.), Research and Education Network, Sydney, Australia.

Objective: The aim of the study was to assess the utility of a novel amyotrophic lateral sclerosis (ALS) diagnostic index (ALSDI).

Methods: A prospective multicenter study was undertaken on patients presenting with suspected ALS. The reference standard (Awaji criteria) was applied to all patients at recruitment. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006876DOI Listing
February 2019
28 Reads
8.286 Impact Factor

Cortical Inhibition of Face and Jaw Muscle Activity and Discomfort Induced by Repetitive and Paired-Pulse TMS During an Overt Object Naming Task.

Brain Topogr 2019 05 23;32(3):418-434. Epub 2019 Jan 23.

Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland.

Modulatory effects of transcranial magnetic stimulation (TMS) strongly depend on the stimulation parameters. Here, we compared the immediate, task-locked inhibitory effects on speech-related muscles and the tolerability of different TMS protocols during a language production task. Repetitive TMS (rTMS) and paired-pulse TMS (PP) were applied in 13 healthy subjects over the primary motor cortex (M1) during a finger-tapping/tongue-twisting tasks. Read More

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http://dx.doi.org/10.1007/s10548-019-00698-9DOI Listing
May 2019
17 Reads

Clinical Utility of Longitudinal Measurement of Motor Threshold in Wilson's Disease.

Can J Neurol Sci 2019 03 22;46(2):251-254. Epub 2019 Jan 22.

Department of Neurology,National Institute of Mental Health & Neurosciences (NIMHANS),Bangalore,India.

This study describes the longitudinal changes of resting motor threshold (RMT) and central motor conduction time (CMCT) in 18 patients with Wilson's disease (WD). The RMT, CMCT, and Global Assessment Scale for Wilson Disease (GAS-WD) were measured at baseline and at follow-up after 12.94 ± 7. Read More

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http://dx.doi.org/10.1017/cjn.2018.379DOI Listing
March 2019
3 Reads
1.599 Impact Factor

Objective auditory brainstem response classification using machine learning.

Int J Audiol 2019 04 21;58(4):224-230. Epub 2019 Jan 21.

b Department of Vision and Hearing Sciences , Anglia Ruskin University , Cambridge , UK.

Objective: The objective of this study was to use machine learning in the form of a deep neural network to objectively classify paired auditory brainstem response waveforms into either: 'clear response', 'inconclusive' or 'response absent'.

Design: A deep convolutional neural network was constructed and fine-tuned using stratified 10-fold cross-validation on 190 paired ABR waveforms. The final model was evaluated on a test set of 42 paired waveforms. Read More

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http://dx.doi.org/10.1080/14992027.2018.1551633DOI Listing
April 2019
1 Read
1.427 Impact Factor

The utility of Jerk-locked back averaging technique in diagnosis of generalized myoclonic epilepsy with normal scalp EEG: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14185

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, 71, Xinmin Street, Changchun, P. R. China.

Rationale: The diagnosis of myoclonic epilepsy and the classification of generalized or partial type may be challenging, especially when the scalp electroencephalogram (EEG) is normal. In such situation, how to apply another electrophysiological technique to begin the diagnosis and classification? The utility of Jerk-locked back averaging technique has been described in our case.

Patient Concerns: A Chinese patient (male, 21 years old) presented with frequent unilateral or bilateral shoulder-jerking. Read More

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http://dx.doi.org/10.1097/MD.0000000000014185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370162PMC
January 2019
11 Reads

The Influence of Anesthesia on Corticocortical Evoked Potential Monitoring Network Between Frontal and Temporoparietal Cortices.

World Neurosurg 2019 Mar 18;123:e685-e692. Epub 2018 Dec 18.

Department of Neurosurgery, Sapporo Medical University, Sapporo, Hokkaido, Japan. Electronic address:

Background: Previous studies have reported the usefulness of intraoperative corticocortical evoked potentials (CCEPs) for preserving language function during brain surgery.

Objective: This study aimed to assess the influence of depth of anesthesia on CCEP to establish its clinical utility.

Methods: Twenty patients with brain tumors or epilepsy who underwent awake craniotomy were included in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183282
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http://dx.doi.org/10.1016/j.wneu.2018.11.253DOI Listing
March 2019
30 Reads

Clinical utility of cervical vestibular-evoked myogenic potentials in predicting residual dizziness after benign paroxysmal positional vertigo.

Clin Neurophysiol 2019 01 22;130(1):95-100. Epub 2018 Nov 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: In the present study, the value of cervical vestibular-evoked myogenic potential (cVEMP) as a predictive factor for residual dizziness after recovery of benign paroxysmal positional vertigo (BPPV) was evaluated.

Methods: The present study included 65 patients who had BPPV and underwent cVEMP testing. Patients were divided into two groups depending on the presence or absence of residual dizziness after recovery of BPPV. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.005DOI Listing
January 2019
12 Reads

Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility.

J Psychiatr Pract 2018 07;24(4):220-229

BELL: Department of Neurosciences, Medical University of South Carolina, Charleston, SC LAUER: Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC LENCH: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC HANLON: Departments of Neurosciences and Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC.

Background: The transcranial magnetic stimulation (TMS)-elicited motor-evoked potential (MEP) is a valuable measure for clinical evaluations of various neurological disorders and is used to determine resting motor threshold for repetitive TMS dosing. Although MEP amplitude is primarily associated with motor system function, there is evidence that nonmotor factors may also influence amplitude. This experiment tested the hypotheses that manipulation of 2 factors (visual attention, cognitive regulation) in human participants would significantly affect MEP amplitude. Read More

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http://dx.doi.org/10.1097/PRA.0000000000000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530802PMC

Electrophysiological underpinnings of response variability in the Go/NoGo task.

Int J Psychophysiol 2018 12 26;134:159-167. Epub 2018 Sep 26.

Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, New South Wales 2522, Australia; NICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Penrith, New South Wales 2751, Australia.

Response variability has been identified as a useful predictor of executive function and performance in non-clinical samples in the Go/NoGo task. The present study explores the utility of reaction time variability (RTV) and EEG measures as predictors of Go/NoGo performance outcomes and ERP component amplitudes. Forty-four young adults had EEG recorded across eyes-closed (EC) and eyes-open (EO) resting states, and during an auditory Go/NoGo task. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2018.09.008DOI Listing
December 2018
11 Reads
2.882 Impact Factor

Detecting differences with magnetoencephalography of somatosensory processing after tactile and electrical stimuli.

J Neurosci Methods 2019 01 12;311:331-337. Epub 2018 Sep 12.

Health Sciences, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland; Jyväskylä Centre for Interdisciplinary Brain Research, University of Jyväskylä, Jyväskylä, Finland.

Background: Deviant stimuli within a standard, frequent stimulus train induce a cortical somatosensory mismatch response (SMMR). The SMMR reflects the brain's automatic mechanism for the detection of change in a somatosensory domain. It is usually elicited by electrical stimulation, which activates nerve fibers and receptors in superficial and deep skin layers, whereas tactile stimulation is closer to natural stimulation and activates uniform fiber types. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.09.014DOI Listing
January 2019
3 Reads

Clinical utility of contact heat evoked potentials (CHEPs) in a case of mentalis nerve lesion.

Clin Neurophysiol Pract 2018 7;3:74-77. Epub 2018 Apr 7.

EMG and Motor Control Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Objective: Nociceptive evoked potentials are still infrequently used in electrodiagnostic studies of single patients. We report a case in which the results of contact heat evoked potentials (CHEPs) provided unique information for the diagnosis.

Methods: After biopsy for a local cementoma, a 21-year-old woman presented with neuropathic pain in the distribution of her left mentalis nerve. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2467981X183001
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http://dx.doi.org/10.1016/j.cnp.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133906PMC
April 2018
9 Reads

Evidence of neurophysiological improvement of early manifestations of small-fiber dysfunction after liver transplantation in a patient with familial amyloid neuropathy.

Clin Neurophysiol Pract 2018 17;3:40-44. Epub 2018 Feb 17.

EMG and Motor Control Section, Neurology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Introduction: Small fiber polyneuropathy (SFP) is a common heralding clinical manifestation of damage to the nervous system in patients with familial amyloidosis. The diagnosis of SFP is a significant factor in the decision to treat a previously asymptomatic gene carrier, as treatment would prevent irreversible nerve damage. This requires detection of the earliest but unequivocal signs of peripheral nerve involvement. Read More

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http://dx.doi.org/10.1016/j.cnp.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133776PMC
February 2018
8 Reads

Ulnar neuropathy with abnormal non-localizing electrophysiology: Clinical, electrophysiological and ultrasound findings.

Clin Neurophysiol 2018 10 12;129(10):2155-2161. Epub 2018 Aug 12.

Hand Institute Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Objective: To systematically study demographic, clinical, electrophysiological and nerve ultrasound characteristics of ulnar neuropathy with abnormal non-localizing electrophysiology (NL-UN) and further define the utility of ultrasound over and above the conventional electro-diagnostic approach.

Method: NL-UNs were prospectively identified from 113 consecutive referrals with suspected ulnar neuropathy. All received electro-diagnostic tests and ulnar nerve ultrasound. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.07.020DOI Listing
October 2018
3 Reads

Audiometric and cVEMP Thresholds Show Little Correlation With Symptoms in Superior Semicircular Canal Dehiscence Syndrome.

Otol Neurotol 2018 10;39(9):1153-1162

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.

Objective: Evaluate the relationship between objective audiometric and vestibular tests and patient symptoms in superior canal dehiscence (SCD) syndrome.

Study Design: Retrospective chart review.

Setting: Tertiary care center. Read More

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http://Insights.ovid.com/crossref?an=00129492-201810000-0002
Publisher Site
http://dx.doi.org/10.1097/MAO.0000000000001910DOI Listing
October 2018
43 Reads