596 results match your criteria Clinical Utility of Evoked Potentials

Utility of intraoperative neuromonitoring for decompression of Chiari type I malformation in 93 adult patients.

J Neurosurg 2022 Apr 29:1-6. Epub 2022 Apr 29.

Objective: There is currently a lack of consensus on the utility of intraoperative neuromonitoring (IONM) for decompression of Chiari type I malformation (CM-I). Commonly used monitoring modalities include somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs), and brainstem auditory evoked potentials (BAEPs). The purpose of this study was to evaluate the utility of IONM in preventing neurological injury for CM-I decompression. Read More

View Article and Full-Text PDF

The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.

J Neurophysiol 2022 May 7;127(5):1253-1268. Epub 2022 Apr 7.

Department of Biomedical Engineering, Duke University, Durham, North Carolina.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) antidromically activates the motor cortex (M1), and this cortical activation appears to play a role in the treatment of hypokinetic motor behaviors (Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. 324: 354-359, 2009; Yu C, Cassar IR, Sambangi J, Grill WM. 40: 4323-4334, 2020). Read More

View Article and Full-Text PDF

Does transcranial direct current stimulation enhance cognitive performance in Parkinson's disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study.

Neurol Sci 2022 Jun 24;43(6):4029-4044. Epub 2022 Mar 24.

Department of Physiology, Graduate School of Health Sciences, Istanbul University, Istanbul, Turkey.

Background: Parkinson's disease-mild cognitive impairment (PD-MCI) is garnering attention as a key interventional period for cognitive impairment. Currently, there are no approved treatments for PD-MCI and encouraging results of transcranial direct current stimulation (tDCS) combined with other interventions have been proposed, though the efficacy and neural mechanisms of tDCS alone have not been studied in PD-MCI yet.

Objectives: The present double-blind, randomized, sham-controlled study assessed the effects of tDCS over the dorsolateral prefrontal cortex on cognitive functions via neuropsychological and electrophysiological evaluations in individuals with PD-MCI for the first time. Read More

View Article and Full-Text PDF

Electroencephalogram (EEG) With or Without Transcranial Magnetic Stimulation (TMS) as Biomarkers for Post-stroke Recovery: A Narrative Review.

Front Neurol 2022 22;13:827866. Epub 2022 Feb 22.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Stroke is one of the leading causes of death and disability. Despite the high prevalence of stroke, characterizing the acute neural recovery patterns that follow stroke and predicting long-term recovery remains challenging. Objective methods to quantify and characterize neural injury are still lacking. Read More

View Article and Full-Text PDF
February 2022

Reduced electrocortical responses to pleasant pictures in depression: A brief report on time-domain and time-frequency delta analyses.

Biol Psychol 2022 04 3;170:108302. Epub 2022 Mar 3.

Department of Psychology, Florida State University, Tallahassee, USA; Department of Biomedical Sciences, Florida State University, Tallahassee, USA.

Background: The late positive potential (LPP) to pleasant content is an electrocortical indicator of blunted emotional reactivity in depression. A reduced time-frequency delta power has never been investigated in clinical samples. The present study examined time-frequency delta in depression and at investigated whether the combination of time-domain and time-frequency data would explain additional variance in the depression status. Read More

View Article and Full-Text PDF

Evaluation and Utility of Submaximal Stimulation Intensity in Transcranial Magnetic Stimulation in the Standing Horse.

J Equine Vet Sci 2022 May 20;112:103912. Epub 2022 Feb 20.

Equine Hospital, Center for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universitaet, Munich, Germany. Electronic address:

Transcranial magnetic stimulation (TMS) has been successfully used in horses to evaluate function and integrity of descending motor pathways in patients affected by neurological gait abnormalities. In preceding studies, lengthening latency times (LT) of cranially evoked limb muscle potentials have been considered a reliable diagnostic parameter. Standardized settings use device output signal intensities of 100%. Read More

View Article and Full-Text PDF

Acute optic neuritis: What do complementary tests add to diagnosis?

Mult Scler Relat Disord 2022 Jan 27;57:103348. Epub 2021 Oct 27.

Sección de Neuroinmunología, División Neurología. Hospital J. M. Ramos Mejía. Centro Universitario de Neurología. Universidad de Buenos Aires (UBA), Buenos Aires, Argentina; Centro Argentino de Neuroinmunología (CADENI), Facultad de Medicina. Universidad de Buenos Aires, Argentina.

Introduction: Optic neuritis (ON) is the inflammation of the optic nerve due in many cases, to a pathological immune response. Since its symptoms can be subtle, diagnosis is sometimes challenging. The value of complementary tests for diagnosis and prognosis of ON was demonstrated in retrospective analysis, but their utility in the acute period of ON has been scarcely studied. Read More

View Article and Full-Text PDF
January 2022

Subcortical Stimulation in Brain Tumor Surgery: A Closer Look Beneath the Surface.

World Neurosurg 2022 May 9;161:55-63. Epub 2022 Feb 9.

Department of Neurological Surgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, USA. Electronic address:

Background: Maximizing the patient's onco-functional balance is the central tenet of brain tumor surgery. Consequently, numerous surgical adjuncts have been developed to facilitate identification of the tumor-brain interface and preservation of functional anatomy. Among these, intraoperative neurophysiologic monitoring (IONM) with direct cortical stimulation (DCS) and subcortical stimulation (SCS) remains the gold standard for real-time, functional mapping of motor and language activity. Read More

View Article and Full-Text PDF

Treating the body to prevent brain injury: lessons learned from the coronavirus disease 2019 pandemic.

Curr Opin Crit Care 2022 04;28(2):176-183

Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Purpose Of Review: We aim to provide the current evidence on utility and application of neuromonitoring tools including electroencephalography (EEG), transcranial Doppler (TCD), pupillometry, optic nerve sheath diameter (ONSD), cerebral near-infrared spectroscopy (cNIRS), somatosensory-evoked potentials (SSEPs), and invasive intracranial monitoring in COVID-19. We also provide recent evidence on management strategy of COVID-19-associated neurological complications.

Recent Findings: Despite the common occurrence of neurological complications, we found limited use of standard neurologic monitoring in patients with COVID-19. Read More

View Article and Full-Text PDF

Visual Evoked Potentials in Neuromyelitis Optica Spectrum Disorders.

J Cent Nerv Syst Dis 2021 21;13:11795735211057315. Epub 2021 Dec 21.

Neurology Service, Clinics Hospital Complex at Universidade Federal do Paraná, Curitiba, Brazil.

Background: Neuromyelitis optica spectrum disorders (NMOSDs) are rare antibody-mediated disorders of the central nervous system, with a predilection for the spinal cord and optic nerves. The clinical utility of evoked potential recordings (EPs) has already been established for multiple sclerosis, in particular, that of the abnormal visual evoked potentials (VEP), a key criterion in the McDonald diagnostic criteria for MS. However, there have been few reports on EPs in patients with NMOSD. Read More

View Article and Full-Text PDF
December 2021

The heartbeat evoked potential is a questionable biomarker in nightmare disorder: A replication study.

Neuroimage Clin 2022 31;33:102933. Epub 2021 Dec 31.

Institute of Psychology, ELTE, Eötvös Loránd University, Budapest, Hungary; UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN - Center for Research in Cognition and Neurosciences and UNI - ULB Neurosciences Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

Frequent nightmares are highly prevalent and constitute a risk factor for a wide range of psychopathological conditions. Despite its prevalence and clinical relevance however, the pathophysiological mechanisms of nightmares are poorly understood. A recent study (Perogamvros et, al 2019) examined the heart beat evoked potential (HEP) in a small group of nightmare sufferers (N = 11) and matched healthy controls (N = 11) and observed markedly different (Hedges' g = 1. Read More

View Article and Full-Text PDF

Characterizing Polarity Sensitivity in Cochlear Implant Recipients: Demographic Effects and Potential Implications for Estimating Neural Health.

J Assoc Res Otolaryngol 2022 Apr 6;23(2):301-318. Epub 2022 Jan 6.

Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 276 Barkley Memorial Center, Lincoln, NE, 68583, USA.

Stimulus polarity can affect both physiological and perceptual measures in cochlear-implant recipients. Large differences between polarities for various outcome measures (e.g. Read More

View Article and Full-Text PDF

Use of the auditory brainstem response for assessment of cochlear synaptopathy in humans.

Naomi F Bramhall

J Acoust Soc Am 2021 12;150(6):4440

Veterans Affairs (VA) Rehabilitation Research & Development Service (RR&D) National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System Portland, Oregon 97239, USA.

Although clinical use of the auditory brainstem response (ABR) to detect retrocochlear disorders has been largely replaced by imaging in recent years, the discovery of cochlear synaptopathy has thrown this foundational measure of auditory function back into the spotlight. Whereas modern imaging now allows for the noninvasive detection of vestibular schwannomas, imaging technology is not currently capable of detecting cochlear synaptopathy, the loss of the synaptic connections between the inner hair cells and afferent auditory nerve fibers. However, animal models indicate that the amplitude of the first wave of the ABR, a far-field evoked potential generated by the synchronous firing of auditory nerve fibers, is highly correlated with synaptic integrity. Read More

View Article and Full-Text PDF
December 2021

Transcranial magnetic stimulation implementation on stroke prognosis.

Neurol Sci 2022 Feb 30;43(2):873-888. Epub 2021 Nov 30.

Neurology Department, Democritus University of Thrace, Alexandroupolis, Greece.

Introduction: Stroke represents a major cause of functional disability with increasing prevalence. Thus, it is imperative that stroke prognosis be both timely and valid. Up to today, several biomarkers have been investigated in an attempt to forecast stroke survivors' potential for motor recovery, transcranial magnetic stimulation (TMS) being among them. Read More

View Article and Full-Text PDF
February 2022

Utility of Dual Monitoring of the Lower Cranial Nerve Motor-Evoked Potentials Threshold Level Criterion to Predict Swallowing Function in Skull Base and Brainstem Surgery.

J Clin Neurophysiol 2021 Nov 22. Epub 2021 Nov 22.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Brain Tumor, National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; and Department of Neuroelectrophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Purpose: Evaluate the value of bilateral final/baseline threshold level changes of lower cranial nerve MEPs in postoperative swallowing function deterioration prediction.

Methods: Bilateral lower cranial nerve motor-evoked potentials (MEPs) were recorded in 51 patients who underwent treatment for skull base and brainstem tumors. Corkscrew-like electrodes were positione 2 cm below C3/C4 and Cz. Read More

View Article and Full-Text PDF
November 2021

Diagnostic accuracy of brain stem auditory evoked response in distinguishing drug-induced parkinsonism from Parkinson'sdisease.

Neurophysiol Clin 2021 Dec 8;51(6):524-532. Epub 2021 Nov 8.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objectives: Brainstem auditory evoked response (BAER) is a non-invasive modality that can be used to investigate brainstem neuronal function in movement disorders. The differentiation between drug-induced parkinsonism (DIP) and Parkinson's disease (PD) can be very challenging. Although PD and DIP to some extent display similar clinical symptoms, the underlying pathophysiologic mechanisms are entirely different. Read More

View Article and Full-Text PDF
December 2021

Recording brain responses to TMS of primary motor cortex by EEG - utility of an optimized sham procedure.

Neuroimage 2021 12 4;245:118708. Epub 2021 Nov 4.

Department of Neurology & Stroke, University of Tübingen, Hoppe-Seyler-Straße 3, Tübingen 72076, Germany; Hertie Institute for Clinical Brain Research, University of Tübingen, Germany. Electronic address:

Introduction: Electroencephalography (EEG) is increasingly used to investigate brain responses to transcranial magnetic stimulation (TMS). A relevant issue is that TMS is associated with considerable auditory and somatosensory stimulation, causing peripherally evoked potentials (PEPs) in the EEG, which contaminate the direct cortical responses to TMS (TEPs). All previous attempts to control for PEPs suffer from significant limitations. Read More

View Article and Full-Text PDF
December 2021

Mismatch negativity amplitude in first-degree relatives of individuals with psychotic disorders: Links with cognition and schizotypy.

Schizophr Res 2021 12 22;238:161-169. Epub 2021 Oct 22.

Stony Brook Medicine, Psychiatry Department, Stony Brook, NY, United States of America. Electronic address:

Mismatch negativity (MMN) amplitude is reliably reduced in psychotic disorders. While several studies have examined this effect in first-degree relatives of individuals with schizophrenia, few have sought to quantify deficits in relatives of individuals with other psychotic disorders. While some conclude that, compared to healthy subjects, first-degree relatives of schizophrenia show reduced MMN, others contradict this finding. Read More

View Article and Full-Text PDF
December 2021

The Clinical Use of Vernier Acuity: Resolution of the Visual Cortex Is More Than Meets the Eye.

Front Neurosci 2021 5;15:714843. Epub 2021 Oct 5.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Vernier acuity measures the ability to detect a misalignment or positional offset between visual stimuli, for example between two vertical lines when reading a vernier scale. It is considered a form of visual hyperacuity due to its detectable thresholds being considerably smaller than the diameter of a foveal cone receptor, which limits the spatial resolution of classical visual acuity. Vernier acuity relies heavily on cortical processing and is minimally affected by optical media factors, making it a useful indicator of cortical visual function. Read More

View Article and Full-Text PDF
October 2021

Development of emotion processing and regulation: Insights from event-related potentials and implications for internalizing disorders.

Int J Psychophysiol 2021 12 14;170:121-132. Epub 2021 Oct 14.

Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, United States of America.

Emotionally-salient stimuli receive selective attention and elicit complex neural responses that evolve considerably across development. Event-related potentials (ERPs) optimally capture the dynamics of emotion processing and regulation, with sensitivity to detect changes in magnitude, latency, and maximal location across development. In this selective qualitative review, we summarize evidence of developmental changes in neural reactivity to emotional stimuli and modulation of neural responses during emotion regulation indexed by ERPs across infancy, childhood, and adolescence. Read More

View Article and Full-Text PDF
December 2021

Roving oddball paradigm elicits sensory gating, frequency sensitivity, and long-latency response in common marmosets.

Jamie A O'Reilly

IBRO Neurosci Rep 2021 Dec 22;11:128-136. Epub 2021 Sep 22.

College of Biomedical Engineering, Rangsit University, 52/347 Muang-Ake, Phaholyothin Road, Pathumthani 12000, Thailand.

Mismatch negativity (MMN) is a candidate biomarker for neuropsychiatric disease. Understanding the extent to which it reflects cognitive deviance-detection or purely sensory processes will assist practitioners in making informed clinical interpretations. This study compares the utility of deviance-detection and sensory-processing theories for describing MMN-like auditory responses of a common marmoset monkey during roving oddball stimulation. Read More

View Article and Full-Text PDF
December 2021

Test-Retest Reliability of Short-Interval Intracortical Inhibition Assessed by Threshold-Tracking and Automated Conventional Techniques.

eNeuro 2021 Sep-Oct;8(5). Epub 2021 Oct 19.

Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus 8200, Denmark

Two novel short-interval intracortical inhibition (SICI) protocols, assessing SICI across a range of interstimulus intervals (ISIs) using either parallel threshold-tracking transcranial magnetic stimulation (TT-TMS) or automated conventional TMS (cTMS), were recently introduced. However, the test-retest reliability of these protocols has not been investigated, which is important if they are to be introduced in the clinic. SICI was recorded in 18 healthy subjects using TT-TMS (T-SICI) and cTMS (A-SICI). Read More

View Article and Full-Text PDF
December 2021

Awake craniotomy with transcortical motor evoked potential monitoring for resection of gliomas within or close to motor-related areas: validation of utility for predicting motor function.

J Neurosurg 2022 04 24;136(4):1052-1061. Epub 2021 Sep 24.

1Department of Neurosurgery.

Objective: The authors previously showed that combined evaluation of changes in intraoperative voluntary movement (IVM) during awake craniotomy and transcortical motor evoked potentials (MEPs) was useful for predicting postoperative motor function in 30 patients with precentral gyrus glioma. However, the validity of the previous report is limited to precentral gyrus gliomas. Therefore, the current study aimed to validate whether the combined findings of IVM during awake craniotomy and transcortical MEPs were useful for predicting postoperative motor function of patients with a glioma within or close to motor-related areas and not limited to the precentral gyrus. Read More

View Article and Full-Text PDF

Neural responses to reward and pleasant pictures prospectively predict remission from depression.

J Abnorm Psychol 2021 Oct 13;130(7):702-712. Epub 2021 Sep 13.

Department of Psychology, Florida State University.

Reduced neural responses to reward and pleasant stimuli-indicators of anhedonia and reduced emotional reactivity, respectively-have been reported among individuals with depressive disorders. The current study examined whether these neural measures could prospectively predict the course of depression among a community-based sample of 83 participants diagnosed with a depressive disorder. At initial assessment, participants performed both a guessing task to elicit the reward positivity (RewP) and a picture viewing paradigm with neutral and pleasant pictures to measure the late positive potential (LPP)-both event-related brain potentials (ERPs) independently related to diagnosis of depression. Read More

View Article and Full-Text PDF
October 2021

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation.

J Vis Exp 2021 08 16(174). Epub 2021 Aug 16.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology.

Most single-pulse transcranial magnetic stimulation (TMS) parameters (e.g., motor threshold, stimulus-response function, cortical silent period) are used to examine corticospinal excitability. Read More

View Article and Full-Text PDF

Steady-State Cortico-cortical Evoked Potential.

J Clin Neurophysiol 2021 Aug 6. Epub 2021 Aug 6.

Department of Neurosurgery, Sapporo Medical University, Sapporo, Japan; Division of Clinical Engineering, Sapporo Medical University Hospital, Sapporo, Japan; and Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: The present study evaluated the utility of the steady-state responses of cortico-cortical evoked potentials (SSCCEPs) and compared them with the responses of conventional CCEPs.

Methods: Eleven patients with medically intractable focal epilepsy who underwent the implantation of subdural electrodes or stereoelectroencephalography were enrolled. Conventional CCEPs were obtained by averaging responses to alternating 1-Hz electrical stimuli, and 5-Hz stimuli were delivered for recording SSCCEPs. Read More

View Article and Full-Text PDF

Large-scale analysis of interindividual variability in single and paired-pulse TMS data.

Clin Neurophysiol 2021 10 6;132(10):2639-2653. Epub 2021 Jul 6.

Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia.

Objective: This study brought together over 60 transcranial magnetic stimulation (TMS) researchers to create the largest known sample of individual participant single and paired-pulse TMS data to date, enabling a more comprehensive evaluation of factors driving response variability.

Methods: Authors of previously published studies were contacted and asked to share deidentified individual TMS data. Mixed-effects regression investigated a range of individual and study level variables for their contribution to variability in response to single and paired-pulse TMS data. Read More

View Article and Full-Text PDF
October 2021

Effects of propofol on cortico-cortical evoked potentials in the dorsal language white matter pathway.

Clin Neurophysiol 2021 08 1;132(8):1919-1926. Epub 2021 Jun 1.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: In order to evaluate the clinical utility even under general anesthesia, the present study aimed to clarify the effect of anesthesia on the cortico-cortical evoked potentials (CCEPs).

Methods: We analyzed 14 patients' data in monitoring the integrity of the dorsal language pathway by using CCEPs both under general anesthesia with propofol and remifentanil and awake condition, with the main aim of clarifying the effect of anesthesia on the distribution and waveform of CCEPs.

Results: The distribution of larger CCEP response sites, including the locus of the maximum CCEP response site, was marginally affected by anesthesia. Read More

View Article and Full-Text PDF

The Utility of Multimodal Intraoperative Neuromonitoring in Spine Surgery: Case Series from a Lower-Middle-Income Country Perspective.

World Neurosurg 2021 08 28;152:e220-e226. Epub 2021 May 28.

Neurosurgery Departments, Cairo University, Cairo, Egypt; Neurosurgery Department, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, Buffalo, New York, USA. Electronic address:

Objective: Multimodal intraoperative neuromonitoring (IOM) using somatosensory-evoked potentials and motor-evoked potentials is a sensitive and specific tool for detecting intraoperative neurologic injury during spine surgery. This study aimed to evaluate the use of multimodal IOM in a lower-middle-income country (LMIC) during cervical and thoracic spine surgery in order to prevent and predict new postoperative neurologic deficits early on. This is the first report of multimodal IOM application in LMICs. Read More

View Article and Full-Text PDF

The role and use of event-related potentials in aphasia: A scoping review.

Brain Lang 2021 08 24;219:104966. Epub 2021 May 24.

Speech-Language Pathology, Saint Gianna School of Health Sciences, University of Mary, 7500 University Dr. Bismarck, ND 58504, USA. Electronic address:

Event-related potentials (ERPs) can provide important insights into underlying language processes in both unimpaired and neurologically impaired populations and may be particularly useful in aphasia. This scoping review was conducted to provide a comprehensive summary of how ERPs have been used with people with aphasia (PWA), with the goal of exploring the potential clinical application of ERPs in aphasia assessment and treatment. We identified 117 studies that met inclusionary criteria, reflecting six thematic domains of inquiry that relate to understanding both unimpaired and aphasic language processing and the use of ERPs with PWA. Read More

View Article and Full-Text PDF