542 results match your criteria Clinical Utility of Evoked Potentials


Spatial-Temporal Functional Mapping Combined With Cortico-Cortical Evoked Potentials in Predicting Cortical Stimulation Results.

Front Hum Neurosci 2021 14;15:661976. Epub 2021 Apr 14.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Functional human brain mapping is commonly performed during invasive monitoring with intracranial electroencephalographic (iEEG) electrodes prior to resective surgery for drug- resistant epilepsy. The current gold standard, electrocortical stimulation mapping (ESM), is time -consuming, sometimes elicits pain, and often induces after discharges or seizures. Moreover, there is a risk of overestimating eloquent areas due to propagation of the effects of stimulation to a broader network of language cortex. Read More

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Reference ranges for clinical electrophysiology of vision.

Doc Ophthalmol 2021 Apr 21. Epub 2021 Apr 21.

Department of Clinical Physics and Bioengineering, Royal Hospital for Children, NHS Greater Glasgow and Clyde, Glasgow, UK.

Introduction: Establishing robust reference intervals for clinical procedures has received much attention from international clinical laboratories, with approved guidelines. Physiological measurement laboratories have given this topic less attention; however, most of the principles are transferable.

Methods: Herein, we summarise those principles and expand them to cover bilateral measurements and one-tailed reference intervals, which are common issues for those interpreting clinical visual electrophysiology tests such as electroretinograms (ERGs), visual evoked potentials (VEPs) and electrooculograms (EOGs). Read More

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The Use of Electroencephalography in Patients with Sepsis: a Review of The Literature.

J Transl Int Med 2021 Mar 5;9(1):12-16. Epub 2021 Jan 5.

Department of Internal Medicine, University of Patras, Achaia, Greece.

Sepsis-associated encephalopathy (SAE) is the term used to define brain dysfunction related to infections that are principally located outside the central nervous system (CNS). A number of published studies report that electroencephalography (EEG) has been used in the evaluation of patients with sepsis, alone or usually in combination, to evoked potentials and neuroimaging. This was in an effort to assess if EEG can be a tool in the diagnosis and monitoring of the neurological status in sepsis patients. Read More

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Predictive value of intraoperative D-wave and m-MEP neurophysiological monitoring in patients with preoperative motor deficits in immediate and late postoperative period.

J Craniovertebr Junction Spine 2021 Jan-Mar;12(1):26-32. Epub 2021 Mar 4.

Department of Neuroanaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Background: Presence of preoperative motor deficits in patients poses a distinct challenge in monitoring the integrity of corticospinal tracts during spinal surgeries. The inconsistency of the motor-evoked potentials is such patients, limits its clinical utility. D-wave is a robust but less utilized technique for corticospinal tract monitoring. Read More

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Normal values for cervical and ocular vestibular-evoked myogenic potentials using EMG scaling: effect of body position and electrode montage.

Acta Otolaryngol 2021 May 27;141(5):440-448. Epub 2021 Feb 27.

Department of Surgery, University of British Columbia, Vancouver, Canada.

Background: The clinical utility of cervical and ocular vestibular-evoked myogenic potential (cVEMP and oVEMP) is limited by variability of testing protocols and a dearth of normative data using contemporary methods for amplitude scaling.

Aims/objectives: To investigate the effect of body position and electrode montage on VEMP responses and to establish normative values.

Material And Methods: This is a repeated measures study of 44 healthy young adult subjects (22 men and 22 women). Read More

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Electroencephalographic Correlates of Obsessive-Compulsive Disorder.

Curr Top Behav Neurosci 2021 Feb 16. Epub 2021 Feb 16.

Department of Psychology, Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK.

This chapter reviews EEG research in Obsessive-Compulsive Disorder (OCD), focusing on Event-Related Potentials (ERPs) such as the Contingent Negative Variation, N2, Error-Related Negativity, the feedback Error-Related Negativity and the Readiness Potential and their neural bases. The functional significance, utility and correlation of these ERPs with OCD symptoms will be discussed, alongside novel theories for integrating the research findings. I will consider hypotheses including goal-directed behaviour, overreliance on habits, dissociations between action and knowledge, and excessive intolerance of uncertainty in the context of EEG studies, thus providing a comprehensive framework of the electroencephalographic literature concerning OCD. Read More

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February 2021

Clinical utility of complex assessment with evoked potentials in acute lymphoblastic leukemia survivors: comparison of various treatment protocols.

BMC Cancer 2021 Feb 10;21(1):150. Epub 2021 Feb 10.

Department of Oncology and Hematology, University Children's Hospital, 265 Wielicka St., 30-663, Krakow, Poland.

Background: One of the greatest success of pediatric hematology is a prominent improvement of survival in acute lymphoblastic leukemia (ALL). Therefore, special attention needs to be paid to long-term side effects of the treatment such as neurotoxicity. One of the few diagnostic methods that allow an objective assessment of sensory systems are evoked potentials (EP). Read More

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February 2021

The Significance of Motor Evoked Potential Changes and Utility of Multimodality Intraoperative Monitoring in Spinal Surgery: A Retrospective Analysis of Consecutive Cases at a Single Institution.

Cureus 2020 Dec 13;12(12):e12065. Epub 2020 Dec 13.

Neurosurgery, Loyola University Medical Center, Maywood, USA.

Objective The objective of the study is to identify specific population groups that may benefit from intraoperative motor evoked potentials (MEP) and to assess positive predictive value (PPV) and negative predictive value (NPV) changes during operation by correlating these with postoperative motor outcomes. Methods We retrospectively reviewed 1,043 consecutive patient cases undergoing spine surgery with and without intraoperative monitoring (IOM) at a single institution from January 1, 2016 to December 31, 2017. Demographic and clinical outcome data were collected at multiple time points. Read More

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December 2020

Multisite Study of Evoked Potentials in Rett Syndrome.

Ann Neurol 2021 Apr 4;89(4):790-802. Epub 2021 Feb 4.

Division of Child Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Objective: The aim of the current study was to evaluate the utility of evoked potentials as a biomarker of cortical function in Rett syndrome (RTT). As a number of disease-modifying therapeutics are currently under development, there is a pressing need for biomarkers to objectively and precisely assess the effectiveness of these treatments.

Method: Yearly visual evoked potentials (VEPs) and auditory evoked potentials (AEPs) were acquired from individuals with RTT, aged 2 to 37 years, and control participants across 5 sites as part of the Rett Syndrome and Related Disorders Natural History Study. Read More

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Clinical Utility of Intraoperative Electrocochleography (ECochG) During Cochlear Implantation: A Systematic Review and Quantitative Analysis.

Otol Neurotol 2021 03;42(3):363-371

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.

Objective: To evaluate the utility of intraoperative electrocochleography (ECochG) as a predictive tool for preservation of residual acoustic hearing after cochlear implantation.

Data Sources: A systematic review employing a multi-database search strategy (Ovid MEDLINE, Embase, EBM Cochrane, and Scopus) was conducted from inception to August 1, 2019. English language studies in humans were included. Read More

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The clinical utility of the cervical vestibular-evoked myogenic potential (cVEMP) in university-level athletes with concussion.

Neurol Sci 2020 Nov 8. Epub 2020 Nov 8.

Department of Psychology, Lamar University, Beaumont, TX, USA.

Introduction: Concussion is defined as a mild traumatic brain injury that can occur in all sport activities. Cervical vestibular-evoked myogenic potentials (cVEMPs) are accepted to demonstrate the vestibulocollic reflex. MAIN: To evaluate subclinical cervical abnormalities in the vestibulospinal pathway in subjects with concussion history with and without related symptoms via evoked vestibular potential. Read More

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November 2020

Intraoperative Neuromonitoring of Blink Reflex During Posterior Fossa Surgeries and its Correlation With Clinical Outcome.

J Clin Neurophysiol 2020 Sep 28. Epub 2020 Sep 28.

Department of Biostatistics and Bioinformatics, Life Science Institute, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Purpose: Blink reflex (BR) under general anesthesia as an intraoperative neuromonitoring method was used to monitor facial nerves in few studies. This study aimed to test the utility of intraoperative BR during cerebellopontine angle and skull base surgeries, assess its prognostic value for facial nerve functions, and compare it with facial corticobulbar motor evoked potentials (CoMEPs).

Methods: Blink reflex and facial CoMEPs were recorded from 40 patients undergoing skull base surgeries. Read More

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September 2020

Pearl and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part II.

Neurol Sci 2020 Dec 18;41(12):3503-3515. Epub 2020 Jul 18.

Neurology Unit, Bambino Gesù Hospital, Rome, Italy.

This review focuses on new and/or less standardized event-related potentials methods, in order to improve their knowledge for future clinical applications. The olfactory event-related potentials (OERPs) assess the olfactory functions in time domain, with potential utility in anosmia and degenerative diseases. The transcranial magnetic stimulation-electroencephalography (TMS-EEG) could support the investigation of the intracerebral connections with very high temporal discrimination. Read More

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December 2020

Feasibility of objective assessment of difference limen for intensity using acoustic change complex in children with central auditory processing disorder.

Int J Pediatr Otorhinolaryngol 2020 Oct 8;137:110189. Epub 2020 Jul 8.

Department of Audiology, All India Institute of Speech and Hearing, Mysore, India.

Introduction: Acoustic change complex (ACC) shows brain's ability to discriminate between acoustic features in an ongoing stimulus. It is this nature of ACC that has generated interest in studying the usefulness of ACC as an objective tool for evaluating difference limens for various stimulus parameters. The present study therefore aimed at investigating the utility of ACC as an objective measure of difference limen for intensity (DLI) in normal hearing children with and without (C)APD. Read More

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October 2020

Full endoscopic unilateral laminotomy for bilateral decompression of the cervical spine: surgical technique and early experience.

J Spine Surg 2020 Jun;6(2):447-456

Department of Neurological Surgery, University of Washington, Seattle, WA, USA.

Background: Full-endoscopic decompression surgery has been shown to be safe and efficacious in the lumbar spine, while its role remains to be determined in the cervical spine. We describe the utility of cervical endoscopic unilateral laminotomy for bilateral decompression (CE-ULBD) in a series of elderly patients with severe central stenosis, significant medical comorbidity, and existing cervical deformity.

Methods: A prospectively collected spine surgery registry at the University of Washington was retrospectively queried for patients with cervical spondylotic myelopathy receiving CE-ULBD. Read More

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Ambient Pressure Tympanometry Wave Patterns in Patients With Superior Semicircular Canal Dehiscence.

Front Neurol 2020 28;11:379. Epub 2020 May 28.

Department of Otolaryngology- Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.

Superior semicircular canal dehiscence (SSCD) is a treatable condition, but current diagnostic modalities have numerous limitations. Clinicians would benefit from an additional tool for diagnostic workup that is both rapid and widely available. To assess the utility of ambient pressure tympanometry (APT) in the diagnostic workup of SSCD by determining the sensitivity and specificity of APT for SSCD in comparison to other diagnostic modalities. Read More

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VEP estimation of visual acuity: a systematic review.

Doc Ophthalmol 2021 Feb 2;142(1):25-74. Epub 2020 Jun 2.

The Department of Clinical and Academic Ophthalmology, Great Ormond Street Hospital for Children, London, UK.

Purpose: Visual evoked potentials (VEPs) can be used to measure visual resolution via a spatial frequency (SF) limit as an objective estimate of visual acuity. The aim of this systematic review is to collate descriptions of the VEP SF limit in humans, healthy and disordered, and to assess how accurately and precisely VEP SF limits reflect visual acuity.

Methods: The protocol methodology followed the PRISMA statement. Read More

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February 2021

Neurophysiological monitoring of spinal cord function during spinal deformity surgery: 2020 SRS neuromonitoring information statement.

Spine Deform 2020 08 25;8(4):591-596. Epub 2020 May 25.

Radboud University Medical Center, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.

The Scoliosis Research Society has developed an updated information statement on intraoperative neurophysiological monitoring of spinal cord function during spinal deformity surgery. The statement reviews the risks of spinal cord compromise associated with spinal deformity surgery; the statement then discusses the various modalities that are available to monitor the spinal cord, including somatosensory-evoked potentials, motor-evoked potentials, and electromyographic (EMG) options. Anesthesia considerations, the importance of a thoughtful team approach to successful monitoring, and the utility of checklists are also discussed. Read More

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Pearls and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian Psychophysiology and Cognitive Neuroscience Society on methodological limits and clinical reliability-part I.

Neurol Sci 2020 Oct 9;41(10):2711-2735. Epub 2020 May 9.

Neurology Ward Unit, Bambino Gesù Hospital, Rome, Italy.

Event-related potentials (ERPs) are obtained from the electroencephalogram (EEG) or the magnetoencephalogram (MEG, event-related fields (ERF)), extracting the activity that is time-locked to an event. Despite the potential utility of ERP/ERF in cognitive domain, the clinical standardization of their use is presently undefined for most of procedures. The aim of the present review is to establish limits and reliability of ERP medical application, summarize main methodological issues, and present evidence of clinical application and future improvement. Read More

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October 2020

The FAST graph: A novel framework for the anatomically-guided visualization and analysis of cortico-cortical evoked potentials.

Epilepsy Res 2020 03 9;161:106264. Epub 2020 Jan 9.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Background: Intracerebral electroencephalography (iEEG) using stereoelectroencephalography (SEEG) methodology for epilepsy surgery gives rise to complex data sets. The neurophysiological data obtained during the in-patient period includes categorization of the evoked potentials resulting from direct electrical cortical stimulation such as cortico-cortical evoked potentials (CCEPs). These potentials are recorded by hundreds of contacts, making these waveforms difficult to quickly interpret over such high-density arrays that are organized in three dimensional fashion. Read More

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Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis.

Neuromodulation 2020 Jun 5;23(4):478-488. Epub 2020 Feb 5.

Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.

Introduction: The P50, a positive auditory-evoked potential occurring 50 msec after an auditory click, has been characterized extensively with electroencephalography (EEG) to detect aberrant auditory electrophysiology in disorders like schizophrenia (SZ) where 61-74% have an auditory gating deficit. The P50 response occurs in primary auditory cortex and several thalamocortical regions. In rodents, the gated P50 response has been identified in the reticular thalamic nucleus (RT)-a deep brain structure traversed during deep brain stimulation (DBS) targeting of the ventral intermediate nucleus (VIM) of the thalamus to treat essential tremor (ET) allowing for interspecies comparison. Read More

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Utility of intraoperative electromyography in placing C7 pedicle screws.

J Neurosurg Spine 2020 Jan 31:1-9. Epub 2020 Jan 31.

1Department of Neurosurgery, Mount Sinai Health System, New York, New York; and.

Objective: The C7 vertebral body is morphometrically unique; it represents the transition from the subaxial cervical spine to the upper thoracic spine. It has larger pedicles but relatively small lateral masses compared to other levels of the subaxial cervical spine. Although the biomechanical properties of C7 pedicle screws are superior to those of lateral mass screws, they are rarely placed due to increased risk of neurological injury. Read More

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January 2020

Persistent postural-perceptual dizziness: Clinical and neurophysiological study.

J Clin Neurosci 2020 Feb 14;72:26-30. Epub 2020 Jan 14.

University Hospital Center Zagreb, Department of Neurology, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.

The aim of this study was to evaluate clinical and neurophysiological characteristics of Persistent postural-perceptual dizziness (PPPD) in a tertiary vertigo clinic. This was a cross-sectional study that included consecutive patients examined in the Vertigo clinic of the University Hospital Center Zagreb, Croatia. The following data were extracted from the electronic hospital records: age, sex, the duration of symptoms, initial trigger event, results of the caloric testing, video head impulse test (vHIT) for all six semicircular canals and ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP). Read More

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February 2020

Integrated In-Ear Device for Auditory Health Assessment.

Annu Int Conf IEEE Eng Med Biol Soc 2019 Jul;2019:56-59

Clinical assessment of the human auditory system is an integral part of evaluating the health of a patient's cognitive processes. Conventional tests performed by audiologists include the Auditory Steady State Response (ASSR) and the Auditory Brainstem Response (ABR), both of which present an audio stimulus to the patient in order to elicit a change in brain state measurable by electroencephalography (EEG) techniques. Spatial monitoring of the electrophysiological activity in the auditory cortex, temporal cortex, and brain stem during auditory stimulus evaluation can be used to pinpoint to location of auditory dysfunction along the auditory pathway. Read More

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Somatosensory Evoked Potentials and Neuroprognostication After Cardiac Arrest.

Neurocrit Care 2020 06;32(3):847-857

Department of Neurosurgery, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building 823, Baltimore, MD, 21201, USA.

Improved understanding of post-cardiac arrest syndrome and clinical practices such as targeted temperature management have led to improved mortality in this cohort. Attention has now been placed on development of tools to aid in predicting functional outcome in comatose cardiac arrest survivors. Current practice uses a multimodal approach including physical examination, neuroimaging, and electrophysiologic data, with a primary utility in predicting poor functional outcome. Read More

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A new parameter to discriminate amyotrophic lateral sclerosis patients from healthy participants by motor cortical excitability changes.

Muscle Nerve 2020 03 20;61(3):354-362. Epub 2020 Jan 20.

Department of Neurology, Clinical Neurophysiology Division, Gazi University Faculty of Medicine, Ankara, Turkey.

Introduction: We sought a combination of abnormalities to define a more sensitive measure of cortical excitability in amyotrophic lateral sclerosis (ALS).

Methods: The automatic threshold tracking method was employed to assess the resting motor threshold, intracortical facilitation (ICF), short-interval intracortical inhibition (SICI), and short-interval intracortical faciilitation (SICF) in patients and controls.

Results: SICF at interstimulus intervals (ISI) between 1 and 1. Read More

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Neurophysiological Correlates of Concussion: Deep Learning for Clinical Assessment.

Sci Rep 2019 11 22;9(1):17341. Epub 2019 Nov 22.

ARiEAL Research Centre, McMaster University, Hamilton, Canada.

Concussion has been shown to leave the afflicted with significant cognitive and neurobehavioural deficits. The persistence of these deficits and their link to neurophysiological indices of cognition, as measured by event-related potentials (ERP) using electroencephalography (EEG), remains restricted to population level analyses that limit their utility in the clinical setting. In the present paper, a convolutional neural network is extended to capitalize on characteristics specific to EEG/ERP data in order to assess for post-concussive effects. Read More

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November 2019

Validating the Utility of High Frequency Ocular Vestibular Evoked Myogenic Potential Testing in the Diagnosis of Superior Semicircular Canal Dehiscence.

Otol Neurotol 2019 12;40(10):1353-1358

Michigan Ear Institute, Farmington Hills, Michigan.

Introduction: Ocular vestibular evoked myogenic potential (oVEMP) is a diagnostic test employed in the evaluation of superior semicircular canal dehiscence (SSCD) syndrome. Previous work showed that the presence of the n10 component of oVEMP at 4000 Hz was diagnostic of SSCD with perfect sensitivity and specificity of 1.0 in a series of 22 patients. Read More

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December 2019

Utility and practice of electrodiagnostic testing in the pediatric population: An AANEM consensus statement.

Muscle Nerve 2020 02;61(2):143-155

Centre de Référence Maladies Neuromusculaires, Service de Neurologie, Réanimation et Réeducation Pédiatriques, Hôpital Raymond Poincaré, Garches, France.

Nerve conduction studies and needle electromyography, collectively known as electrodiagnostic (EDX) studies, have been available for pediatric patients for decades, but the accessibility of this diagnostic modality and the approach to testing vary significantly depending on the physician and institution. The maturation of molecular diagnostic approaches and other diagnostic technologies such as neuromuscular ultrasound indicate that an analysis of current needs and practices for EDX studies in the pediatric population is warranted. The American Association of Neuromuscular & Electrodiagnostic Medicine convened a consensus panel to perform literature searches, share collective experiences, and develop a consensus statement. Read More

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February 2020