4,026 results match your criteria Clinical Transplantation[Journal]


Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation.

Clin Transplant 2019 Feb 15:e13496. Epub 2019 Feb 15.

Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Background: Systemic right ventricular [RV] failure may progress necessitating referral for orthotropic heart transplantation [OHT]. Pulmonary hypertension [PH] frequently coexists in adult congenital heart disease and can complicate the assessment for OHT.

Methods: Single-center case series of six patients [median age 34. Read More

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http://dx.doi.org/10.1111/ctr.13496DOI Listing
February 2019

Successful repair of kidney graft artery rupture secondary to infection using a preprocessed homologous "Y"-shaped iliac artery.

Clin Transplant 2019 Feb 1:e13493. Epub 2019 Feb 1.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University.

Objectives: This retrospective study aims to describe novel ways of repair kidney allograft artery rupture secondary to infection using a preprocessed homologous "Y"-shaped iliac artery.

Methods: Five patients' whose course was complicated by graft arterial rupture were included in the rupture group and patients who received the kidney from the same donor were included in the control group. In the rupture group, the iliac artery used for revascularization was harvested from a DCD donor, pre-treated with absolute diethyl ether, followed by absolute alcohol, and then preserved in 75% alcohol. Read More

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February 2019

Antibiotic prophylaxis for ureteral stent removal after kidney transplantation.

Clin Transplant 2019 Jan 29:e13491. Epub 2019 Jan 29.

Division of Nephrology and Hypertension, Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York, New York.

There are no guidelines for antibiotic prophylaxis for ureteral stent removal after kidney transplantation. We reviewed the charts of 277 adult kidney transplant recipients with ureteral stents transplanted at our center between September 2014 and December 2015 and investigated whether antibiotic prophylaxis for stent removal was associated with reduced incidence of urinary tract infections (UTI). We defined UTI as a urine culture ≥10  CFU/mL of bacterial isolates irrespective of symptoms. Read More

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http://dx.doi.org/10.1111/ctr.13491DOI Listing
January 2019
1 Read

The evolving risk of sudden cardiac death after heart transplant. An analysis of the ISHLT Thoracic Transplant Registry.

Clin Transplant 2019 Jan 29:e13490. Epub 2019 Jan 29.

Heart Failure and Transplantation Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Sudden cardiac death (SCD) is responsible for ~10% of post-heart transplant deaths. We conducted a retrospective analysis of the ISHLT registry evaluating the risk of post-transplant SCD. Adult heart transplant recipients (2004-2014) surviving the first year were included. Read More

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http://dx.doi.org/10.1111/ctr.13490DOI Listing
January 2019

Baseline living-donor kidney volume and function associate with 1-year post-nephrectomy kidney function.

Clin Transplant 2019 Jan 28:e13485. Epub 2019 Jan 28.

Department of Internal Medicine, Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City, Utah.

Living donors may develop kidney dysfunction more often than equally healthy populations. The purpose of this study was to determine whether computed tomography-assessed remaining kidney volume indexed to body surface area (RKV/BSA) was associated with 1-year post-nephrectomy renal function independent of baseline renal function. Using multivariable regression, we modeled 1-year estimated glomerular filtration rate (eGFR) and eGFR <60 mL /min/1. Read More

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January 2019

A Positive Deviance Approach to Improve Familial Authorization for Organ Donation.

Clin Transplant 2019 Jan 28:e13488. Epub 2019 Jan 28.

Department of Communication, University at Buffalo - State University of New York.

The current study evaluates the Positive Deviance Donation Collaborative, a communication training program designed to identify and disseminate behaviors of requesters with above-average rates of familial authorization to organ donation. The program initiated with a cohort of 99 requesters from 11 OPOs. Requesters' quarterly authorization rates were monitored for 33 months and their pre-/post-intervention skills in active empathic listening and self-efficacy to request donation were assessed. Read More

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http://dx.doi.org/10.1111/ctr.13488DOI Listing
January 2019

The Ethical Conundrum: Conflicting Advocacy Positions in Advanced Heart Failure Therapy.

Clin Transplant 2019 Jan 28:e13489. Epub 2019 Jan 28.

Division of Cardiothoracic Surgery, G.S. Kakos, MD and T.E. Williams, Jr., MD, PhD Endowed Professor in Cardiac Surgery; Associate Director, Surgical Service, Heart& Vascular Center;, The Ohio State University Wexner Medical Center; N-825 Doan Hall;, 410 West 10th Ave. Columbus, OH, 43210.

It is estimated that nearly 6.5 million Americans over the age of 20 suffer from heart failure. Heart failure is the leading cause of hospitalization in patients over 65 years of age, and carries with it a 5-year mortality of nearly 50%. Read More

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http://dx.doi.org/10.1111/ctr.13489DOI Listing
January 2019

A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain-dead organ donors.

Clin Transplant 2019 Jan 28:e13486. Epub 2019 Jan 28.

Mid-America Transplant, St. Louis, Missouri.

Rationale: Brain-dead (BD) organ donors frequently exhibit hemodynamic instability and/or reversible cardiac dysfunction. Retrospective studies have suggested that thyroid hormone may stabilize hemodynamics and enhance myocardial recovery. Intravenous levothyroxine (T4) is most frequently utilized but studies have suggested that triiodothyronine (T3) may be superior. Read More

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January 2019

Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.

Clin Transplant 2019 Jan 28:e13487. Epub 2019 Jan 28.

University of California, San Francisco, Kidney Transplant Service, CA, 94143-0780, United States.

Background: We investigated circulating levels of individual soluble urokinase plasminogen activation receptor (suPAR) forms to determine if specific circulating fragments of suPAR (II-III) and (I) can better serve as clinical biomarkers for FSGS and the risk of recurrence after transplantation.

Materials And Methods: Serum levels of intact suPAR and its cleaved forms were measured with 2 assays, ELISA and TR-FIA 2.

Results: suPAR levels in healthy controls were significantly lower than those who had glomerular diseases but were not significantly different between FSGS patients and glomerular controls. Read More

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January 2019
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Prognostic value of the PaO2/FiO2 ratio determined at the end-surgery stage of a double-lung transplantation.

Clin Transplant 2019 Jan 22:e13484. Epub 2019 Jan 22.

Department of Anesthesiology, Hôpital Foch, 92150, Suresnes, France.

Introduction: We evaluated the prognostic role of the arterial oxygen partial pressure / fractional inspired oxygen ratio (PaO2/FiO2 ratio) measured at the end of double-lung transplantation (DLT).

Methods: This was a monocentric cohort study of all consecutive DLT patients between January 1st, 2012 and January 1st, 2016 except patients with pre-operative extracorporeal membrane oxygenation (ECMO), intraoperative cardiopulmonary bypass, post-operative ECMO, large patent foramen ovale, redo transplantation during the study period, and multiorgan transplantation.

Results: 164 patients were included in the study; 45 had a PaO2/FiO2 ratio < 200, 39 a ratio in the range 200-300, and 80 a ratio >300. Read More

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http://dx.doi.org/10.1111/ctr.13484DOI Listing
January 2019
2 Reads

Can reporting more lead to less? The role of metrics in assessing liver transplant program performance.

Clin Transplant 2019 Jan;33(1):e13385

Department of Surgery, Section of Transplantation, University of Chicago, Chicago, Illinois.

Appropriate metrics for performance analysis is an active topic of debate within the transplant community. This study explores current proposals on metric expansion as well as potential metrics and prospective collaborations that have not received widespread discussion within the transplant community. The premature introduction of additional, nonvalidated metrics risks behaviors that may undermine donor utilization and patient access to transplantation. Read More

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http://dx.doi.org/10.1111/ctr.13385DOI Listing
January 2019

Chylous ascites following laparoscopic live donor nephrectomy: A new improved treatment paradigm.

Clin Transplant 2019 Jan 19:e13483. Epub 2019 Jan 19.

Department of Surgery, Columbia University Medical Center, New York, New York.

Chylous ascites is a difficult, albeit uncommon complication of laparoscopic live donor nephrectomy (LLDN). Lymphatic leak is believed to be a result of injury to the cisterna chyli, regional lymph nodes, or other peri-aortic lymphatics intraoperatively. Recommended management with dietary modifications can result in malnutrition and immunodeficiency. Read More

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http://dx.doi.org/10.1111/ctr.13483DOI Listing
January 2019
3 Reads

UK registry analysis of donor substance misuse and outcomes following pancreas transplantation.

Clin Transplant 2019 Jan 19:e13481. Epub 2019 Jan 19.

NIHR Blood and Transplant Research Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, UK.

Substance abuse is unfortunately common in organ donors. Often, these organs are declined for transplant, not only because of concerns around blood-borne virus transmission but also because of perceived poor outcomes. In kidney transplantation, previous studies have demonstrated donor smoking status significantly impacts transplant outcome, but intravenous drug use or alcohol dependence does not. Read More

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http://doi.wiley.com/10.1111/ctr.13481
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http://dx.doi.org/10.1111/ctr.13481DOI Listing
January 2019
5 Reads

Description and analysis of patients and outcomes following third-time heart transplantation: An analysis of the United Network for Organ Sharing database from 1985 to 2017.

Clin Transplant 2019 Jan 19:e13482. Epub 2019 Jan 19.

Department of Cardiovascular and Thoracic Surgery, Rush Medical Center, Chicago, Illinois.

Background: Following second heart transplantation (HTx), some patients experience graft failure and require third-time heart transplantation. Little data exist to guide decision-making with regard to repeat retransplantation in older patients.

Methods: We performed a retrospective cohort analysis of patients receiving a third HTx, as identified in the United Network for Organ Sharing (UNOS) database from 1985 to 2017. Read More

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http://doi.wiley.com/10.1111/ctr.13482
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January 2019
4 Reads

Extracorporeal membrane oxygenation for grade 3 primary graft dysfunction after lung transplantation: long-term outcomes.

Clin Transplant 2019 Jan 18:e13480. Epub 2019 Jan 18.

Thoracic Surgery Department, Foch Hospital, Suresnes, France.

Introduction: Extracorporeal membrane oxygenation (ECMO) is an efficient and innovative therapeutic tool for primary graft dysfunction (PGD). However, its effect on survival and long-term lung function are not well-known. This study evaluated those parameters in patients with PGD requiring ECMO. Read More

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http://doi.wiley.com/10.1111/ctr.13480
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January 2019
4 Reads

Bacteremia in kidney transplant recipients: Burden, causes, and consequences.

Clin Transplant 2019 Jan 16:e13479. Epub 2019 Jan 16.

Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Bacteremia is an important complication after kidney transplantation. We examined bacteremia and its outcomes in a large cohort of kidney transplant recipients. Kidney transplants from 1-Jul-2004 to 1-Dec-2014 at the Toronto General Hospital were eligible for study inclusion. Read More

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http://doi.wiley.com/10.1111/ctr.13479
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January 2019
24 Reads

The Correlation between Conventional Coagulation Tests and Thromboelastography in Each Phase of Liver Transplantation.

Clin Transplant 2019 Jan 12:e13478. Epub 2019 Jan 12.

Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Introduction: Thromboelastography (TEG) is gaining increasing acceptance in liver transplantation (LT) with conventional coagulation tests (CCTs) such as prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (ATIII), platelet count (PLT) and fibrinogen concentration. The purpose of this study was to evaluate the clinical utility of TEG in LT, and investigate the correlation between TEG and CCT values during each phase of LT.

Materials And Methods: Medical records of patients who underwent deceased donor LT at a single, university hospital between October 2010 and July 2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1111/ctr.13478DOI Listing
January 2019
2 Reads

Bone mineral density and osteoporosis in heart transplanted patients: A single-center retrospective study at Skåne University Hospital in Lund 1988-2016.

Clin Transplant 2019 Jan 7:e13477. Epub 2019 Jan 7.

Department of Clinical Sciences Lund, Cardiology, Lund University, Lund, Sweden.

Bone mineral density (BMD) in the lumbar spine and femoral neck, the incidence of osteoporosis, and survival up to 10 years after heart transplantation (HT) were investigated in 169 patients who underwent HT at Skåne University Hospital in Lund, Sweden, 1988-2016. Within the first year post-transplantation, mean (SD) BMD decreased by 3.9% (10. Read More

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http://doi.wiley.com/10.1111/ctr.13477
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January 2019
6 Reads

An Evaluation of a Motor Vehicle Facility Campaign with an Established Statewide Donor Registry: A Test of Sustainable, Evidence-Based Intervention Strategies.

Clin Transplant 2019 Jan 5:e13475. Epub 2019 Jan 5.

University of Illinois at Urbana-Champaign.

Increasing organ donor registration enrollment inside motor vehicle facilities (MVF) is a common approach in the United States. From this research, a formula for what works has emerged within the literature including the presence of an interpersonal component, video messages, and point-of-decision materials. These intervention components have demonstrated effectiveness at increasing registrations in relatively new statewide registries; however, their effectiveness in MVFs with a mature registry remains understudied. Read More

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http://doi.wiley.com/10.1111/ctr.13475
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January 2019
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Early experience with the use of hepatitis C antibody-positive, nucleic acid testing-negative donors in lung transplantation.

Clin Transplant 2019 Jan 4:e13476. Epub 2019 Jan 4.

Department of Surgery, Duke University, Durham, North Carolina.

Historically, potential lung donors who have detectable antibodies to hepatitis C virus have been declined by most centers due to concern for possible disease transmission. We sought to evaluate hepatitis C viral transmission rates from donors who were known to be HCV Ab positive but HCV NAT negative. We performed a single-center retrospective review of a prospectively collected database for lung transplant recipients at our center including HCV Ab+NAT- donors (approved January 2017). Read More

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http://doi.wiley.com/10.1111/ctr.13476
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January 2019
5 Reads

Uncontrolled deceased cardiac donation: An unutilized source for organ transplantation in the United States.

Clin Transplant 2018 Dec 31:e13474. Epub 2018 Dec 31.

Division of Transplant Surgery, Department of Surgery, University of Colorado Hospital, Aurora, Colorado.

The practice of uncontrolled donation after cardiac death (uDCD) has been met with tepid interest within the United States transplant community. Hesitancy stems largely from fears of eroding public trust due to complex ethical issues involving consent. Beyond ethical concerns, uDCD creates unique logistic challenges to obtain and to preserve organs within a short time frame. Read More

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http://dx.doi.org/10.1111/ctr.13474DOI Listing
December 2018
1 Read

Reply to the letter of Dr Merdin.

Clin Transplant 2018 Dec 30:e13457. Epub 2018 Dec 30.

Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.

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December 2018
2 Reads

Prevalence, determinants, and correlates of coagulation necrosis and contraction band necrosis in donor hearts.

Clin Transplant 2018 Dec 29:e13472. Epub 2018 Dec 29.

LifeLink of Florida, Tampa, Florida.

Background: Exploration of pathologic changes in donor hearts and finding the association of pathologic findings with potentially reversible cardiac condition may result in allowing such hearts to recover and be used for transplantation.

Methods: We enrolled consecutive donors from one federally designated Organ Procurement Organization for one calendar year. Hearts rejected for transplantation underwent pathological examination. Read More

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December 2018
1 Read

Persistent acidosis after reperfusion-A prognostic indicator of increased 30-day and in-hospital postoperative mortality in liver transplant recipients.

Clin Transplant 2018 Dec 29:e13473. Epub 2018 Dec 29.

Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

During liver transplantation, the patient is at risk of developing progressive lactic acidosis. Following reperfusion, correction of acidosis may occur. In some patients, acidosis will worsen, a phenomenon referred to as persistent acidosis after reperfusion (PAAR). Read More

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http://dx.doi.org/10.1111/ctr.13473DOI Listing
December 2018
3 Reads

Increasing living donation by implementing the Kidney Coach Program.

Clin Transplant 2018 Dec 27:e13471. Epub 2018 Dec 27.

Recanati Miller Transplantation Institute, Mount Sinai Hospital, New York City, New York.

Candidates for living donor kidney transplantation (LDKT) find it difficult to discuss living donation with people in their social network, and there is a lack of useful interventions to train them. The Kidney Coach Program (KCP) was developed to equip individuals (advocates for candidates and candidate themselves) with the tools needed to find potential donors. The purpose of this pilot study is to evaluate the effects of the KCP on increasing the number of people considering living donation. Read More

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http://dx.doi.org/10.1111/ctr.13471DOI Listing
December 2018
1 Read

Longitudinal immunosuppression data can minimize misclassification bias in solid organ transplantation cohorts.

Clin Transplant 2018 Dec 26:e13470. Epub 2018 Dec 26.

Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales, Australia.

Background: Most cohort studies investigating the effect of immunosuppression on transplant outcomes use drugs at first hospital discharge. We evaluated the extent of drug exposure misclassification and its impact on outcome prediction.

Methods: We retrospectively collected longitudinal immunosuppression data, at discharge and at 1, 5, 10, and 15 years after transplantation, and outcomes for solid organ transplant recipients 1984-2006 (n = 3133). Read More

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December 2018
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Early hospital readmission after kidney transplantation under a public health care system.

Clin Transplant 2018 Dec 23:e13467. Epub 2018 Dec 23.

Nephrology Division, Hospital do Rim, Federal University of São Paulo, São Paulo, Brazil.

Early hospital readmission (EHR) is associated with increased mortality after kidney transplantation. This is influenced by population demographics and the comprehensiveness of the healthcare system. We investigated the incidence and risk factors associated with EHR and 1-year patient and graft survivals. Read More

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http://doi.wiley.com/10.1111/ctr.13467
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December 2018
9 Reads

Incidence and variables associated with 30-day mortality after lung transplantation.

Clin Transplant 2018 Dec 22:e13468. Epub 2018 Dec 22.

Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: With the introduction of the lung allocation score (LAS), sicker patients are prioritized for lung transplantation (LT). There is a lack of data regarding variables independently associated with 30-day mortality after LT.

Methods: We queried the UNOS database for adult patients undergoing LT between 1989 and 2014. Read More

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December 2018
1 Read

Molecular signatures and clinical outcomes of transplant glomerulopathy stratified by microvascular inflammation and donor-specific antibody.

Clin Transplant 2018 Dec 22:e13469. Epub 2018 Dec 22.

Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, New York City, New York.

Background: We investigated clinical outcomes and molecular signatures of transplant glomerulopathy (TG) stratified by microvascular inflammation (MVI) and donor-specific antibody (DSA) status.

Methods: We performed a retrospective review of 749 kidney transplant patients who received a for-cause kidney biopsy from 2009 to 2014. We classified TG as MVI positive (MVI+) or MVI negative (MVI-), and with or without DSA. Read More

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December 2018
2 Reads

Disparity in access to kidney allograft offers among transplant candidates with human immunodeficiency virus.

Clin Transplant 2018 Dec 21:e13466. Epub 2018 Dec 21.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Despite a survival benefit from transplantation and acceptable outcomes, patients with human immunodeficiency virus (HIV+) face barriers to kidney transplantation. Little is known about the acceptance or decline of organ offers on their behalf because waitlist registry data do not include HIV serostatus.

Methods: We performed a retrospective cohort study using match run data from the Organ Procurement and Transplantation Network, including every kidney offer from May 1, 2007, to July 3, 2013. Read More

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http://dx.doi.org/10.1111/ctr.13466DOI Listing
December 2018
2 Reads

Comment on'' ''Immunophenotypic profile and clinical outcome of monoclonal B-cell lymphocytosis in kidney transplantation'' by Alfano G, Fontana F, Colaci E, et al., Clin Transplant, 2018 Aug;32(8):e13338, doi: 10.1111/ctr.13338, Epub 2018 Aug 26.''.

Authors:
Alparslan Merdin

Clin Transplant 2019 Jan 19;33(1):e13455. Epub 2018 Dec 19.

Hematology Clinic and Bone Marrow Transplantation Unit, University of Health Sciences Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/ctr.13455DOI Listing
January 2019
1 Read

Complications related to totally implantable venous access devices in children and adults following lung transplantation.

Clin Transplant 2018 Dec 18:e13465. Epub 2018 Dec 18.

Division of Pulmonary and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Introduction: Totally implantable venous access devices (TIVADs) are the preferred devices for patients with advanced lung disease who require long-term venous access. The primary purpose of this study was to describe the natural history of TIVADs left in place at the time of transplant.

Methods: This multicenter retrospective cohort study evaluated pediatric and adult lung transplant recipients from 5/5/2005 to 12/31/17 with pretransplant TIVAD. Read More

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December 2018
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Outcome of sirolimus-based immunosuppression, fifteen years post-live-donor kidney transplantation: Single-center experience.

Clin Transplant 2018 Dec 13:e13463. Epub 2018 Dec 13.

Nephrology Division, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

In a prospective randomized controlled trial, between May 2001 and January 2003, 132 live-donor kidney transplant recipients were randomized to receive sirolimus primary immunosuppression, either in combination with low dose tacrolimus (Tac group) or in combination with mycophenolate mofetil (MMF group). We have previously reported on 2- and 5-year follow-up results, with favorable patient and graft outcomes obtained in both groups. In view of recent published reports of increased risk of inferior outcomes among sirolimus-treated patients, we herein present results of an observational extension of the previously randomized patients 15 years post-transplantation. Read More

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December 2018
1 Read
1.486 Impact Factor

Optimizing the clinical utility of sirolimus-based immunosuppression for kidney transplantation.

Clin Transplant 2018 Dec 13:e13464. Epub 2018 Dec 13.

Clínica Universitaria Colombia, Fundacion Universitária de Ciencias de la Salud, Bogotá, Colombia.

While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long-term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection-associated death. Immunosuppression strategies are needed to balance risks of acute and subclinical rejection with long-term benefits of improved kidney function. Sirolimus, an inhibitor of mammalian target of rapamycin, is used for immunosuppression in kidney transplantation. Read More

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http://dx.doi.org/10.1111/ctr.13464DOI Listing
December 2018
3 Reads

Recipient working status is independently associated with outcomes in heart and lung transplantation.

Clin Transplant 2018 Dec 13:e13462. Epub 2018 Dec 13.

Division of Cardiac Surgery, University of California, Los Angeles, California.

Employment status may capture elements of patients' physical strength, mental resilience, and socioeconomic status to better prognosticate transplant outcomes. This study characterized the effect of working status on thoracic transplant outcomes by evaluating the United Network for Organ Sharing registry for adult lung or heart transplants from 2005 to 2016. Kaplan-Meier estimates illustrated 5-year and 10-year survival by working status at transplant, while multivariable Cox proportional hazards regressions controlled for baseline differences, including functional and socioeconomic status. Read More

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http://dx.doi.org/10.1111/ctr.13462DOI Listing
December 2018
1 Read

The effect of donor alcohol abuse on outcomes following heart transplantation.

Clin Transplant 2018 Dec 11:e13461. Epub 2018 Dec 11.

Department of Cardiology, Loyola University Medical Center, Maywood, Illinois.

Background: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients.

Methods: Overall, 370 HTx recipients were divided into two groups: (a) the alcoholic donor group (AD, n = 58) and (b) the non-alcoholic donor group (NAD, n = 312). Read More

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http://dx.doi.org/10.1111/ctr.13461DOI Listing
December 2018
4 Reads
1.486 Impact Factor

Epidemiology and outcomes of dengue in kidney transplant recipients: A 20-year retrospective analysis and comparative literature review.

Clin Transplant 2019 Jan 26;33(1):e13458. Epub 2018 Dec 26.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Kidney transplant (KT) recipients in dengue-endemic areas are at risk of exposure. We investigated the epidemiology and outcomes from dengue in KT recipients at our transplant center and conducted a literature review.

Materials And Methods: We conducted a 20-year retrospective study of KT recipients who were diagnosed with laboratory-confirmed dengue from January 1997 to September 2017 according to the 2009 World Health Organization (WHO) classification. Read More

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http://dx.doi.org/10.1111/ctr.13458DOI Listing
January 2019
3 Reads

Marijuana use in transplantation: A call for clarity.

Clin Transplant 2018 Dec 2:e13456. Epub 2018 Dec 2.

Transplant and Immunocompromised Host Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Transplant centers have varying policies for marijuana (MJ) use in donors, transplant candidates, and recipients. Rationales for these differences range from concerns for fungal complications, impaired adherence, and drug interactions. This paper reviews the current status of MJ policies and practices in transplant centers and results of a survey sent to the American Society of Transplantation (AST) membership by the Executive Committee of the AST Infectious Diseases Community of Practice. Read More

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http://doi.wiley.com/10.1111/ctr.13456
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December 2018
2 Reads

Outcomes after lung transplantation for patients with occupational lung diseases.

Clin Transplant 2019 Jan 30;33(1):e13460. Epub 2018 Dec 30.

Division of Lung Failure and Lung Transplantation, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. Read More

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http://doi.wiley.com/10.1111/ctr.13460
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http://dx.doi.org/10.1111/ctr.13460DOI Listing
January 2019
20 Reads

Severe hypertension is an independent risk factor for posterior reversible encephalopathy syndrome post-hematopoietic cell transplantation in children with thalassemia major.

Clin Transplant 2019 Jan 30;33(1):e13459. Epub 2018 Dec 30.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center (Pediatrics), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognized serious complication of cyclosporine A (CSA) and tacrolimus (TAC) use in hematopoietic cell transplantation (HCT) recipients.

Procedure: A retrospective study was carried out, including 84 cases of HCT for TM from January 2012 to January 2017. Eleven cases were diagnosed with PRES. Read More

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http://doi.wiley.com/10.1111/ctr.13459
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http://dx.doi.org/10.1111/ctr.13459DOI Listing
January 2019
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1.486 Impact Factor

Safety and tolerability of high-intensity statin therapy in heart transplant patients receiving immunosuppression with tacrolimus.

Clin Transplant 2019 Jan 18;33(1):e13454. Epub 2018 Dec 18.

Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina.

Background: Following heart transplantation (HT), HMG CoA reductase inhibitors (statins) have been shown to reduce total and low-density lipoprotein (LDL) cholesterol, development of cardiac allograft vasculopathy (CAV), and mortality. Studies in HT patients have demonstrated the safety of low/moderate intensity statins; however, little data exist using high-intensity (HI) statins. The study aim was to evaluate the safety and efficacy of HI statins in HT recipients receiving tacrolimus. Read More

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http://doi.wiley.com/10.1111/ctr.13454
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http://dx.doi.org/10.1111/ctr.13454DOI Listing
January 2019
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Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study.

Clin Transplant 2019 Jan 9;33(1):e13453. Epub 2018 Dec 9.

Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado.

Background: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls.

Methods: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery <37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital >3 days, infant death/transfer to acute facility and low birthweight (<2500 g). Read More

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http://dx.doi.org/10.1111/ctr.13453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342653PMC
January 2019
3 Reads

Lipid lowering in dialysis patients with cardiovascular disease who are awaiting kidney transplantation.

Clin Transplant 2019 Jan 14;33(1):e13452. Epub 2018 Dec 14.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Dyslipidemias are highly prevalent in chronic kidney disease, end-stage renal disease, and kidney transplant patients. These dyslipidemias are associated with high cardiovascular risk and mortality. Many clinical trials have shown that statin therapy can significantly reduce adverse cardiovascular events in chronic kidney disease patients and kidney transplant recipients. Read More

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January 2019
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Prehabilitation prior to kidney transplantation: Results from a pilot study.

Clin Transplant 2019 Jan 21;33(1):e13450. Epub 2018 Dec 21.

Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.

Prehabilitation is the process of enhancing preoperative functional capacity to improve tolerance for the upcoming stressor; it was associated with improved postoperative outcomes in a handful of studies, but never evaluated in transplantation. Kidney transplant (KT) candidates may be uniquely suited for prehabilitation because they experience a profound loss of functional capacity while waiting years on dialysis. To better understand the feasibility and effectiveness of prehabilitation in KT, we conducted a pilot study of center-based prehabilitation for candidates; this intervention consisted of weekly physical therapy sessions at an outpatient center with at-home exercises. Read More

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http://dx.doi.org/10.1111/ctr.13450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342659PMC
January 2019
8 Reads

Robot-assisted laparoscopic vs laparoscopic donor nephrectomy in renal transplantation: A meta-analysis.

Clin Transplant 2019 Jan 7;33(1):e13451. Epub 2019 Jan 7.

Department of Urological Organ Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, P. R. China.

Background: Currently, the robot-assisted laparoscopic donor nephrectomy (RDN) technique is used for live donor nephrectomy. Does it provide sufficient safety and benefits for living donors? We conducted a meta-analysis to assess the safety and efficacy of RDN compared with the laparoscopic donor nephrectomy (LDN).

Material And Methods: Eligible studies were retrieved and screened from electronic databases from 1999 onward: PubMed, Cochrane Library, and Web of Science. Read More

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January 2019
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Implementation of a transition model to adult care may not be enough to improve results: National study of kidney transplant recipients.

Clin Transplant 2019 Jan 12;33(1):e13449. Epub 2018 Dec 12.

Abdominal Center/Nephrology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Adolescents with a kidney transplant (KT) require special attention during the transition of care. Few longitudinal studies have assessed the effect of transition models (TM) on patient outcomes. Between 1986 and 2013, 239 pediatric patients underwent KT in Finland, of whom 132 have been transferred to adult care. Read More

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January 2019
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The impact of blood pressure variability and pulse pressure on graft survival and mortality after kidney transplantation.

Clin Transplant 2019 Jan 6;33(1):e13448. Epub 2018 Dec 6.

Universitätsklinikum Marien Hospital Herne, Medizinische Klinik I, Ruhr-University of Bochum, Bochum, Germany.

Background: Blood pressure variability and pulse pressure are strong and independent predictors of cardiovascular morbidity and mortality in the general population. So far, there are no data on the impact of blood pressure variability on mortality and graft survival after renal transplantation.

Methods: We performed a retrospective analysis of 877 patients who underwent kidney transplantation between 1997 and 2011 in two transplant centers in Germany (Berlin and Bochum) with a follow-up of 12-266 months. Read More

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http://doi.wiley.com/10.1111/ctr.13448
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January 2019
14 Reads

Use of Twitter in communicating living solid organ donation information to the public: An exploratory study of living donors and transplant professionals.

Clin Transplant 2019 Jan 7;33(1):e13447. Epub 2018 Dec 7.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: As transplant centers start leveraging Twitter for information dissemination and public engagement, it is important to understand current living solid organ donation-related Twitter use.

Methods: We identified public Twitter profiles available in 01/2017 that referenced living organ donation and analyzed the use of donation-related Twitter handles, names, or profile information. Tweets were manually abstracted and qualitatively analyzed for common themes. Read More

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http://doi.wiley.com/10.1111/ctr.13447
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http://dx.doi.org/10.1111/ctr.13447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352984PMC
January 2019
9 Reads

Lung cancer after lung transplantation: An analysis of 25 years of experience in a single institution.

Clin Transplant 2019 Jan 5;33(1):e13446. Epub 2018 Dec 5.

Groupe de transplantation pulmonaire, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg Cedex, France.

Background: The aim of our study was to describe the lung cancer characteristics in lung transplant recipients at our institution.

Methods: Between January 1, 1992, and August 15, 2017, 463 patients underwent lung transplantation.

Results: We found a total of 19 lung cancers (4. Read More

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http://doi.wiley.com/10.1111/ctr.13446
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http://dx.doi.org/10.1111/ctr.13446DOI Listing
January 2019
3 Reads

Pain management and safety profiles after preoperative vs postoperative thoracic epidural insertion for bilateral lung transplantation.

Clin Transplant 2018 Dec 6;32(12):e13445. Epub 2018 Dec 6.

Division of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Objective: Thoracic epidural analgesia provides effective pain control after lung transplantation; however, the optimal timing of placement is controversial. We sought to compare pain control and pulmonary and epidural morbidity between patients receiving preoperative vs postoperative epidurals.

Methods: Institutional records were reviewed for patients undergoing a bilateral lung transplant via a bilateral anterior thoracotomy with transverse sternotomy incision between January 2014 and January 2017. Read More

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http://doi.wiley.com/10.1111/ctr.13445
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December 2018
12 Reads