4,877 results match your criteria Clinical Toxicology[Journal]


Severe and prolonged flecainide intoxication treated by extracorporeal life support: possible role of cytochrome P450 2D6 polymorphism?

Clin Toxicol (Phila) 2019 Feb 13:1-2. Epub 2019 Feb 13.

b Louvain Centre for Toxicology and Applied Pharmacology , Université Catholique de Louvain, Brussels , Belgium.

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http://dx.doi.org/10.1080/15563650.2018.1542703DOI Listing
February 2019

Response to carpenter and colleagues.

Clin Toxicol (Phila) 2019 Feb 13:1-2. Epub 2019 Feb 13.

c Division of Emergency Medicine , Duke University School of Medicine , Durham , NC , USA.

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http://dx.doi.org/10.1080/15563650.2018.1554816DOI Listing
February 2019

In Memoriam Michael Alister McGuigan, M.D.

Clin Toxicol (Phila) 2019 Feb 13. Epub 2019 Feb 13.

c Professor of Clinical Medicine and Emergency Medicine: Executive Director TN Poison Center , Vanderbilt University Medical Center - Nashville , TN , USA.

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http://dx.doi.org/10.1080/15563650.2018.1560464DOI Listing
February 2019

The usefulness of non-contrast abdominal computed tomography for detection of residual drugs in the stomach of patients with acute drug overdose.

Clin Toxicol (Phila) 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Emergency Medicine , Yonsei University Wonju College of Medicine , Wonju , Republic of Korea.

Objectives: If clinicians can know that there are many life-threatening drugs left in the stomach through a non-invasive method over 60 min after drugs ingestion, it may be preferable to minimize absorption of remnant drugs through various methods according to the characteristic of the drug. Computed tomography (CT) has gained wide acceptance in the detection of drug mules. Therefore, we evaluated the prevalence of drugs in the gastric lumen using abdominal non-contrast CT, performed over 60 min after acute drug poisoning. Read More

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http://dx.doi.org/10.1080/15563650.2018.1542702DOI Listing
February 2019

Giant Hogweed phytophotodermatitis.

Clin Toxicol (Phila) 2019 Feb 10:1-2. Epub 2019 Feb 10.

b Department of Surgery, Division of Plastic and Reconstructive Surgery , Virginia Commonwealth University Health System , Richmond , VA , USA.

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http://dx.doi.org/10.1080/15563650.2018.1559327DOI Listing
February 2019

Effect of early and focused benzodiazepine therapy on length of stay in severe alcohol withdrawal syndrome.

Clin Toxicol (Phila) 2019 Feb 7:1-4. Epub 2019 Feb 7.

b Department of Surgery , University of California, Davis Medical Center , Sacramento , CA, USA.

Objective: Current evidence supports symptom-triggered therapy for alcohol withdrawal syndrome (AWS). Early, escalating therapy with benzodiazepines (BZD) appears to decrease ICU length of stay (LOS); however, the effect on hospital LOS remains unknown. The hypothesis of this study is that focused BZD treatment in the first 24 h will decrease hospital LOS. Read More

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http://dx.doi.org/10.1080/15563650.2018.1542701DOI Listing
February 2019
1 Read

The utility of droperidol in the treatment of cannabinoid hyperemesis syndrome.

Clin Toxicol (Phila) 2019 Feb 7:1-5. Epub 2019 Feb 7.

a Austin Clinical School , University of Melbourne , Melbourne , Australia.

Introduction: Cannabinoid hyperemesis syndrome (CHS) can be characterized by recurrent paroxysmal episodes of intractable nausea and vomiting, abdominal pain, and compulsive hot showers/baths with symptom relief, on the background of chronic cannabis use. We reported the use of droperidol in the management of CHS.

Methods: We performed a retrospective review of electronic medical records of Emergency Department presentations to a single tertiary level metropolitan hospital between January 2006 and December 2016 using search keywords: "cannabis", "cannabinoid", "cannabis", "hyperemesis", and "droperidol". Read More

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http://dx.doi.org/10.1080/15563650.2018.1564324DOI Listing
February 2019

Chronological serum concentration of imazapyr in a case of life threatening intoxication.

Clin Toxicol (Phila) 2019 Feb 7:1-2. Epub 2019 Feb 7.

a Department of Emergency Medicine , Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan.

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http://dx.doi.org/10.1080/15563650.2018.1562070DOI Listing
February 2019
1 Read

Poison control centers and alternative forms of communicating with the public: what's all the chatter about?

Clin Toxicol (Phila) 2019 Feb 7:1-6. Epub 2019 Feb 7.

a New York City Poison Control Center , New York , NY, USA.

Context: Short messaging service (SMS or text messaging) allows for the exchange of electronic text messages. Online chatting refers to Internet-based transmission of messages for real-time conversation. Poison Control Centers (PCCs) in the United States communicate with the public primarily via telephone. Read More

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http://dx.doi.org/10.1080/15563650.2018.1546865DOI Listing
February 2019

Comparative effectiveness of methylene blue versus intravenous lipid emulsion in a rodent model of amlodipine toxicity.

Clin Toxicol (Phila) 2019 Feb 7:1-6. Epub 2019 Feb 7.

b Faculty of Medicine, Department of Clinical Pharmacology , Zagazig University , Zagazig , Egypt.

Context: Calcium channel blocker (CCB) poisonings are the leading cause of death from cardiovascular medication-related overdoses. Current treatments (calcium salts, vasopressors, inotropes) are often insufficient. Intravenous lipid emulsion (ILE) and methylene blue (MB) show promise in treating CCB overdoses unresponsive to conventional therapy. Read More

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http://dx.doi.org/10.1080/15563650.2018.1560461DOI Listing
February 2019
1 Read

Comparing clinical outcomes between two scorpion antivenom dosing strategies in children.

Clin Toxicol (Phila) 2019 Feb 7:1-5. Epub 2019 Feb 7.

c Department of Pediatrics , Arizona Children's Center at Maricopa Medical Center , Phoenix, AZ , USA.

Background And Objectives: The clinical course from scorpion envenomation can range from mild to life threatening, particularly in younger children. The F(ab') antivenom currently available in the United States is extremely effective for countering the neurotoxic effects but extremely expensive. This dose comparison study assesses clinical outcomes between two antivenom dosing strategies. Read More

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http://dx.doi.org/10.1080/15563650.2018.1551546DOI Listing
February 2019

The impact of the introduction of a toxicology service on the intensive care unit.

Clin Toxicol (Phila) 2019 Feb 7:1-6. Epub 2019 Feb 7.

f Department of Emergency Medicine , Cairns Hospital , Cairns , Australia.

Objective: To examine the impact of a clinical toxicology service on toxicology patients admitted to an intensive care department Methods: The authors performed a retrospective chart audit of all patients presenting to Cairns Emergency Department (ED) over a five-year period from 2011 to 2016 with a toxicology diagnosis requiring Intensive Care Unit (ICU) admission. They were divided into two groups: pre-toxicology (1 April 2011 to 30 September 2012), and post-toxicology service (1 October 2012 to 31 of March 2016) introduction. Patients were identified using ED and ICU databases. Read More

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http://dx.doi.org/10.1080/15563650.2019.1566553DOI Listing
February 2019

Status epilepticus after C-4 ingestion: using liquid chromatography to quantify toxicity.

Clin Toxicol (Phila) 2019 Feb 7:1-3. Epub 2019 Feb 7.

c Department of Neurology , William Beaumont Army Medical Center , El Paso , TX , USA.

Context: C-4, a commonly used explosive in military operations, is sometimes consumed by soldiers as a rite of passage. The primary component of C-4 is cyclotrimethylenetrinitramine, or Research Department Explosive (RDX), which causes euphoria along with nausea, vomiting, renal injury, encephalopathy and convulsions when consumed in toxic amounts. We present a case of status epilepticus caused by known ingestion of C-4, in which serum levels of the compound were measured with high-performance liquid chromatography (HPLC). Read More

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http://dx.doi.org/10.1080/15563650.2018.1562069DOI Listing
February 2019
1 Read

An open-label randomized trial of intramuscular olanzapine versus oral clonidine for symptomatic treatment of opioid withdrawal in the emergency department.

Clin Toxicol (Phila) 2019 Feb 4:1-6. Epub 2019 Feb 4.

a Department of Emergency Medicine , Hennepin County Medical Center , Minneapolis , MN , USA.

Background: Patients with opioid withdrawal often present to the Emergency Department (ED), but many EDs do not have the infrastructure in place to initiate treatment with opioid agonists (methadone or buprenorphine). Therefore, ED management often entails symptomatic control. The purpose of this study was to compare olanzapine to clonidine for the treatment of opioid withdrawal symptoms. Read More

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http://dx.doi.org/10.1080/15563650.2018.1547828DOI Listing
February 2019

Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon.

Clin Toxicol (Phila) 2019 Feb 1:1-3. Epub 2019 Feb 1.

a Instituto de Pesquisa Clínica Carlos Borborema, Fundacão de Medicina Tropical Dr. Heitor Vieira Dourado , Manaus , Brazil.

Introduction: The common lancehead snakes (Bothrops atrox) are responsible for up to 90% of snakebites in the Amazon, especially in remote areas. The prevalence of microhematuria is similar to that of coagulopathy in B. atrox envenomation in the Amazon. Read More

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http://dx.doi.org/10.1080/15563650.2018.1560463DOI Listing
February 2019
1 Read

Clinical consequences related to a defective elimination of clobazam caused by homozygous mutated CYP2C19 allele.

Clin Toxicol (Phila) 2019 Jan 30:1-5. Epub 2019 Jan 30.

e Département de Réanimation Médicale et de Médecine Hyperbare , CHU d'Angers , Angers , France.

Introduction: Voluntary drug intoxication with benzodiazepines is common and in most cases without consequences. We report an interesting case of voluntary drug intoxication with clobazam (CLB) in a patient with a homozygous mutated CYP2C19 genotype.

Case Report: A 63-year-old Caucasian man was admitted to an intensive care unit for voluntary drug intoxication with CLB (1200 mg) complicated by prolonged hospitalization (46 days). Read More

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http://dx.doi.org/10.1080/15563650.2018.1550198DOI Listing
January 2019

Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases.

Clin Toxicol (Phila) 2019 Jan 30:1-9. Epub 2019 Jan 30.

a Emergency Department , Hospital Clínic, Barcelona; IDIBAPS , Barcelona , Spain.

Objective: To analyse the epidemiology, clinical picture and emergency department (ED) management of a large series of patients who presented to European EDs after cocaine consumption, comparing data from powder (C group) and crack (C group) consumers.

Methods: Between October 2013 and December 2016, the Euro-DEN Plus Registry recorded 17,371 consecutive acute recreational drug toxicity presentations to 22 EDs in 14 European countries. Epidemiological and demographic data, co-ingestion of alcohol and other drugs, clinical features, ED management and outcome (death) were analysed for cocaine cases, and comparison of clinical picture in C and C patients were performed adjusting for alcohol and other drug co-ingestion. Read More

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http://dx.doi.org/10.1080/15563650.2018.1549735DOI Listing
January 2019
1 Read

COPD and asthma therapeutics for supportive treatment in organophosphate poisoning.

Clin Toxicol (Phila) 2019 Jan 30:1-8. Epub 2019 Jan 30.

a Bundeswehr Institute of Pharmacology and Toxicology , Neuherbergstraße 11, Munich , Germany.

Context: Nerve agents like sarin or VX have repeatedly been used in military conflicts or homicidal attacks, as seen in Syria or Malaysia 2017. Together with pesticides, nerve agents assort as organophosphorus compounds (OP), which inhibit the enzyme acetylcholinesterase. To counteract subsequent fatal symptoms due to acetylcholine (ACh) accumulation, oximes plus atropine are administered, a regimen that lacks efficacy in several cases of OP poisoning. Read More

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http://dx.doi.org/10.1080/15563650.2018.1540785DOI Listing
January 2019

Cerebellar syndrome associated with ingestion of Mediterranean Microcosmus: a French case series.

Clin Toxicol (Phila) 2019 Jan 30:1-3. Epub 2019 Jan 30.

a Clinical Pharmacology , Poison Control Center, St Marguerite Hospital , Marseille , France.

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http://dx.doi.org/10.1080/15563650.2018.1506131DOI Listing
January 2019

Clinical outcome of paraquat poisoning during pregnancy.

Clin Toxicol (Phila) 2019 Jan 28:1-6. Epub 2019 Jan 28.

b Faculty of Medicine, Ramathibodi Poison Center , Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.

Objectives: We aimed to describe clinical characteristics and outcomes of paraquat poisoning in pregnant patients, their fetuses, and newborns.

Methods: We performed a retrospective study of pregnant patients who were exposed to paraquat, from the Ramathibodi Poison Center Toxic Exposure Surveillance System, during a 5-year period.

Results: Thirty-six patients, representing every trimester, were included. Read More

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http://dx.doi.org/10.1080/15563650.2018.1549328DOI Listing
January 2019

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 Jan 28:1-9. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
January 2019
1 Read

Determination of carboxyhemoglobin half-life in patients with carbon monoxide toxicity treated with high flow nasal cannula oxygen therapy.

Clin Toxicol (Phila) 2019 Jan 28:1-7. Epub 2019 Jan 28.

b Department of Emergency Medicine , Faculty of Medicine, Kocaeli University , Kocaeli , Turkey.

Background: Acute carbon monoxide poisoning is a common environmental emergency worldwide. Treatment options are limited to normobaric oxygen therapy with a nonrebreather face mask or endotracheal tube and hyperbaric oxygen. The aim of this study is to determine the half-life of carboxyhemoglobin (COHb) in adult patients admitted to the emergency department with acute carbon monoxide poisoning receiving high flow nasal cannula (HFNC) oxygen. Read More

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http://dx.doi.org/10.1080/15563650.2018.1540046DOI Listing
January 2019
1 Read

Multiple organ failure and shock following acute alpha lipoic acid (ALA) intoxication.

Clin Toxicol (Phila) 2019 Jan 28:1-2. Epub 2019 Jan 28.

a Department of Anesthesiology, Intensive Care and Pain Medicine , Emergency Department of General Civil, Hospital, "G. Mazzini" , Piazza Italia 64100 , Teramo , Italia.

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http://dx.doi.org/10.1080/15563650.2018.1551545DOI Listing
January 2019

Early pathology in venom-induced consumption coagulopathy by Rhabdophis tigrinus (Yamakagashi snake) envenomation.

Clin Toxicol (Phila) 2019 Jan 28:1-4. Epub 2019 Jan 28.

e Department of Dermatology, Graduate School of Medical Science , Kyushu University , Fukuoka , Japan.

Objective: Rhabdophis tigrinus (Yamakagashi in Japanese) is a venomous non-front-fanged colubroid snake capable of inflicting envenoming with life-threatening defibrinating coagulopathy. However, because of the uncommon incidence of bites and tendency for late development of symptoms/signs, the early effects of the venom on the coagulation system are poorly known.

Case Report: We describe a boy bitten by a wild R. Read More

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http://dx.doi.org/10.1080/15563650.2018.1540045DOI Listing
January 2019
2 Reads

Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis.

Clin Toxicol (Phila) 2019 Jan 28:1-7. Epub 2019 Jan 28.

l Department of Emergency Medicine , University of Colorado School of Medicine , Denver , CO , USA.

Context: The Rumack-Matthew nomogram stratifies patients into discrete risk zones following acetaminophen (APAP) overdose. Treatment decisions have traditionally been based on the initial risk zone. "Line-crossing" between zones occurs and is poorly understood. Read More

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http://dx.doi.org/10.1080/15563650.2018.1529320DOI Listing
January 2019

Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience.

Clin Toxicol (Phila) 2019 Jan 28:1-2. Epub 2019 Jan 28.

a Rocky Mountain Poison and Drug Center , Denver Health and Hospital Authority , Denver , CO , USA.

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http://dx.doi.org/10.1080/15563650.2018.1510127DOI Listing
January 2019

Seizures in tramadol overdoses reported in the ToxIC registry: predisposing factors and the role of naloxone.

Clin Toxicol (Phila) 2019 Jan 24:1-5. Epub 2019 Jan 24.

a Georgia Poison Center, Grady Hospital , Atlanta , GA , USA.

Importance: Tramadol prescriptions have increased as fewer schedule II and III drugs are prescribed. There has been a concomitant increase in overdoses and adverse events recorded in the National Poison Data System. Seizure activity after tramadol overdose or therapeutic use is a well-documented adverse event. Read More

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http://dx.doi.org/10.1080/15563650.2018.1547826DOI Listing
January 2019

An accidental exposure to dimethyl sulfate.

Clin Toxicol (Phila) 2019 Jan 24:1-2. Epub 2019 Jan 24.

a Chemical Accident Emergency and Rescue Center, Shanghai Institute of Occupational Disease for Chemical Industry , Shanghai , China.

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http://dx.doi.org/10.1080/15563650.2018.1547827DOI Listing
January 2019

Acute cannabis toxicity.

Clin Toxicol (Phila) 2019 Jan 24:1-8. Epub 2019 Jan 24.

a Department of Emergency Medicine, Oregon Poison Center , Oregon Health & Science University , Portland , OR, USA.

Objective: We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.

Methods: This was an observational study of Oregon/Alaska Poison Center data between 4 December 2015 and 15 April 2017. A standardized data collection instrument was created for this study that captured information about cannabis product description, route of exposure, intentional vs unintentional exposure, product dose, product manufacture source, product ownership source, initial vital signs, clinical signs and symptoms, and subject disposition. Read More

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http://dx.doi.org/10.1080/15563650.2018.1548708DOI Listing
January 2019

Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptions.

Clin Toxicol (Phila) 2019 Jan 24:1-6. Epub 2019 Jan 24.

c The Statistical Consulting Center, Department of Public Health and Information Science , University of Louisville , Louisville , KY, USA.

Objective: Gabapentin is a gamma-aminobutyric acid (GABA) analog approved by the Food and Drug Administration (FDA) for partial seizures and post-herpetic neuralgia. Due to its wide therapeutic window and minimal adverse effects, it is frequently prescribed for additional off-label uses. The purpose of this study was to characterize the number, exposure reason, medical outcomes, and disposition of gabapentin exposures reported to one regional poison control center (PCC). Read More

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http://dx.doi.org/10.1080/15563650.2018.1538518DOI Listing
January 2019
1 Read

Acute toxicity following analytically confirmed use of the novel psychoactive substance (NPS) methiopropamine. A report from the Identification of Novel psychoActive substances (IONA) study.

Clin Toxicol (Phila) 2019 Jan 24:1-5. Epub 2019 Jan 24.

c Clinical Toxicology, Newcastle Hospitals NHS Foundation Trust , Newcastle , UK.

Objective: Use of the New Psychoactive Substance (NPS) methiopropamine was first reported in 2011, but there are limited data on its acute toxicity. We report 11 patients presenting with analytically confirmed methiopropamine use.

Methods: Adults presenting to 26 hospitals in the UK with severe acute toxicity after suspected NPS use were recruited from March 2015 to April 2018. Read More

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http://dx.doi.org/10.1080/15563650.2018.1538519DOI Listing
January 2019
1 Read

Emergency management of chlorine gas exposure - a systematic review.

Clin Toxicol (Phila) 2019 Jan 23:1-22. Epub 2019 Jan 23.

a AP-HP, EMS (Samu 92) Occupational Health Unit , Poincaré Hospital , Garches , France.

Introduction: Chlorine exposure can lead to pulmonary obstruction, reactive airway dysfunction syndrome, acute respiratory distress syndrome and, rarely, death.

Objective: We performed a systematic review of published animal and human data regarding the management of chlorine exposure.

Methods: Three databases were searched from 2007 to 2017 using the following keywords "("chlorine gas" OR "chlorine-induced" OR" chlorine-exposed") AND ("therapy" OR "treatment" OR "post-exposure")". Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
Publisher Site
http://dx.doi.org/10.1080/15563650.2018.1519193DOI Listing
January 2019
8 Reads

Phytophotodermatitis with Peucedanum paniculatum: an endemic species to Corsica.

Clin Toxicol (Phila) 2019 Jan 22;57(1):68-69. Epub 2019 Jan 22.

a Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Hôpital Sainte Marguerite, Clinical Pharmacology and Poison Control Centre , Marseille , France.

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
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http://dx.doi.org/10.1080/15563650.2018.1491986DOI Listing
January 2019
4 Reads

Comments on Chhabria et al. "Lipid emulsion for acute organophosphate insecticide poisoning".

Clin Toxicol (Phila) 2019 Jan 22. Epub 2019 Jan 22.

b Section of Medical Toxicology, Division of Emergency Medicine , Washington University School of Medicine , Saint Louis , MO , USA.

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http://dx.doi.org/10.1080/15563650.2018.1542154DOI Listing
January 2019

Button battery exposures in Australian children: a prospective observational study highlighting the role of poisons information centres.

Clin Toxicol (Phila) 2019 Jan 21:1-7. Epub 2019 Jan 21.

a NSW Poisons Information Centre , The Children's Hospital at Westmead , Sydney , Australia.

Context: Button battery ingestion is a worldwide problem, with evidence of increasing harms and deaths in recent decades. Australian Poisons Information Centre (PIC) experience includes cases of treatment delay due to lack of healthcare professional recognition of risks, and/or lack of local resources. This study aims to characterise Australian button battery exposures, focusing on exposure circumstances, and preventable health system shortcomings. Read More

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http://dx.doi.org/10.1080/15563650.2018.1537492DOI Listing
January 2019
1 Read
3.122 Impact Factor

Poisoning with malicious or criminal intent: characteristics and outcome of patients presenting for emergency care.

Clin Toxicol (Phila) 2019 Jan 14:1-4. Epub 2019 Jan 14.

a Division of Pediatric Emergency Medicine , Hospital for Sick Children , Toronto , ON , Canada.

Background: Poisoning is the leading cause of injury-related death in the USA. Poisoning with malicious or criminal intent is uncommon, and poorly characterized.

Objectives: To explore substances, patients' demographics, clinical presentation, management and outcome in victims of malicious poisoning in the USA. Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
Publisher Site
http://dx.doi.org/10.1080/15563650.2018.1546009DOI Listing
January 2019
8 Reads

Correction.

Authors:

Clin Toxicol (Phila) 2018 Jan;56(1):80

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http://dx.doi.org/10.1080/15563650.2018.1550035DOI Listing
January 2018
1 Read

The others: characterizing "other" therapeutic errors reported to a poison center.

Clin Toxicol (Phila) 2019 Jan 2:1-5. Epub 2019 Jan 2.

a Department of Pharmacy Practice and Science, Maryland Poison Center , University of Maryland School of Pharmacy , Baltimore , MD , USA.

Background: Therapeutic errors are costly and result in unplanned hospital visits. Recent poison center studies on therapeutic errors have focused on coded data from either the National Poison Data System (NPDS) or individual poison centers. Approximately 21% of therapeutic errors reported to NPDS are coded as "other incorrect dose" (OI) or "other/unknown therapeutic error" (OU). Read More

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http://dx.doi.org/10.1080/15563650.2018.1538520DOI Listing
January 2019
1 Read

Clinical outcomes from early use of digoxin-specific antibodies versus observation in chronic digoxin poisoning (ATOM-4).

Clin Toxicol (Phila) 2018 Dec 26:1-6. Epub 2018 Dec 26.

b Queensland Poisons Information Centre , South Brisbane , Queensland , Australia.

Introduction: In our previous study on chronic digoxin poisoning, there was a minor improvement after treatment with digoxin-specific antibody (digoxin-Fab). We hypothesised patients with elevated digoxin concentrations may derive little benefit from digoxin-Fab because their presenting complaint was more closely related to their multiple co-morbidities. We aimed to compare the outcome of patients who were initially treated with digoxin-Fab with those that received supportive care. Read More

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http://dx.doi.org/10.1080/15563650.2018.1546010DOI Listing
December 2018
1 Read

Loperamide misuse to avoid opioid withdrawal and to achieve a euphoric effect: high doses and high risk.

Clin Toxicol (Phila) 2018 Dec 26:1-6. Epub 2018 Dec 26.

c Department of Emergency Medicine, New Jersey Poison Information and Education System , Rutgers New Jersey Medical School , Newark , NJ , USA.

Introduction: Loperamide is a readily accessible nonprescription medication that is increasingly being used surreptitiously as an opioid substitute to alleviate the symptoms of acute opioid withdrawal. The objective of this study was to determine the clinical characteristics of patients with loperamide misuse and toxicity.

Methods: The ToxIC registry, a nationwide, prospectively collected cohort of patients evaluated by medical toxicologists was searched from November 2011-December 2016 for patients with loperamide exposure. Read More

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http://dx.doi.org/10.1080/15563650.2018.1510128DOI Listing
December 2018
8 Reads

2017 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 35th Annual Report.

Clin Toxicol (Phila) 2018 Dec 21;56(12):1213-1415. Epub 2018 Dec 21.

h Oklahoma Center for Poison and Drug Information , University of Oklahoma College of Pharmacy , Oklahoma City , OK , USA.

Introduction: This is the 35th Annual Report of the American Association of Poison Control Centers' (AAPCC) National Poison Data System (NPDS). As of 1 January 2017, 55 of the nation's poison centers (PCs) uploaded case data automatically to NPDS. The upload interval was 8. Read More

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http://dx.doi.org/10.1080/15563650.2018.1533727DOI Listing
December 2018
2 Reads

Prevalence of recent fentanyl use among treated users of illicit opioids in England: based on piloted urine drug screens.

Clin Toxicol (Phila) 2018 Dec 16:1-4. Epub 2018 Dec 16.

b Centre for Mental Health and Safety , University of Manchester , Manchester , UK.

Objective: To use a pilot of national fentanyl screening to establish the current prevalence of recent fentanyl use among treated users of illicit opioids in the English treatment system and inform the design of a full study.

Design: Cross-sectional fentanyl metabolite urine screening in randomly-selected study sites, stratified to cover all nine geographical regions of England, supplemented with self-report subsequent to a positive fentanyl test.

Patients: 468 adult (18 years of age and above) patients receiving treatment for opioid use disorder, screened December 2017 to May 2018. Read More

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http://dx.doi.org/10.1080/15563650.2018.1527927DOI Listing
December 2018
1 Read

Berg adder (Bitis atropos) envenoming: an analysis of 14 cases.

Clin Toxicol (Phila) 2018 Dec 6:1-6. Epub 2018 Dec 6.

b Division of Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Tygerberg Poison Information Centre , Stellenbosch University , Cape Town , South Africa.

Introduction: The berg adder (Bitis atropos) is a little-studied, lesser-known viperid snake found in southern Africa and there is limited information available regarding the manifestations of envenoming.

Materials And Methods: This observational series of 14 cases documents features of berg adder envenoming over a period of 16 years (1987-2003). Clinical features of envenomed patients: All 14 patients developed local cytotoxic effects. Read More

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http://dx.doi.org/10.1080/15563650.2018.1499931DOI Listing
December 2018
2 Reads

Datura and Brugmansia plants related antimuscarinic toxicity: an analysis of poisoning cases reported to the Taiwan poison control center.

Clin Toxicol (Phila) 2018 Dec 6:1-8. Epub 2018 Dec 6.

b Division of Clinical Toxicology & Occupational Medicine, Department of Medicine , Taipei Veterans General Hospital , Taipei , Taiwan.

Introduction: Datura and Brugmansia plants, especially Datura species, have been used for their hallucinogenic effects in the United States and Europe; whereas Datura plants have been used as a traditional medicine in many Asian countries. This study was conducted to better understand the pattern and outcome of Datura/Brugmansia plant related poisoning in Taiwan.

Methods: This is a retrospective case series study of all cases with Datura/Brugmansia exposure reported to the Taiwan Poison Control Center between 1986 and 2015. Read More

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http://dx.doi.org/10.1080/15563650.2018.1513527DOI Listing
December 2018
5 Reads

A bona fide need for a non-intravenous cyanide medical countermeasure.

Authors:
Gary A Rockwood

Clin Toxicol (Phila) 2018 Dec 7. Epub 2018 Dec 7.

a Medical Toxicology Division , US Army Medical Research Institute of Chemical Defense , Aberdeen Proving Ground , Maryland , USA.

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http://dx.doi.org/10.1080/15563650.2018.1530780DOI Listing
December 2018
1 Read

Correction.

Authors:

Clin Toxicol (Phila) 2018 Dec 11. Epub 2018 Dec 11.

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http://dx.doi.org/10.1080/15563650.2018.1541630DOI Listing
December 2018
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An analytically confirmed non-fatal intoxication by carfentanil in Sweden.

Clin Toxicol (Phila) 2018 Nov 28:1-3. Epub 2018 Nov 28.

b Department of Laboratory Medicine , Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/15563650.2018.1520999DOI Listing
November 2018
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Prolonged coma resulting from massive levothyroxine overdose and the utility of N-terminal prohormone brain natriuretic peptide (NT-proBNP).

Clin Toxicol (Phila) 2018 Nov 28:1-3. Epub 2018 Nov 28.

a Monash Clinical Toxicology Unit, Emergency Medicine Service, Monash Health , Melbourne , VIC , Australia.

Introduction: Levothyroxine overdose rarely results in systemic toxicity. We report a case of intentional levothyroxine overdose with a delayed onset coma and delirium lasting two weeks.

Case Summary: A 72-year-old female ingested 12 mg levothyroxine. Read More

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http://dx.doi.org/10.1080/15563650.2018.1533639DOI Listing
November 2018
2 Reads