9,984 results match your criteria Clinical Science[Journal]


Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.

Clin Sci (Lond) 2019 Apr 23. Epub 2019 Apr 23.

Center for Molecular Genetics, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China.

Accumulation of reactive oxygen species is a common phenomenon in cardiac stress conditions, for instance, coronary artery disease, aging-related cardiovascular abnormalities, and exposure to cardiac stressors such as hydrogen peroxide (HO). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner membrane protein, shown to involve in the regulation of mitochondrial dynamics. Although Mtp18 is abundant in cardiac muscles, its role in cardiac apoptosis remains elusive. Read More

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http://dx.doi.org/10.1042/CS20190125DOI Listing

Prenatal Cold Exposure Causes Hypertension in Offspring by Hyperactivity of the Sympathetic Nervous System.

Clin Sci (Lond) 2019 Apr 23. Epub 2019 Apr 23.

Daping Hospital, The Third Military Medical University, Chongqing, China

Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect the physiological phenotype of the offspring, including blood pressure elevation. In the present study, we found that adult offspring of dams exposed to cold have increased systolic and diastolic blood pressure, and decreased urine volume and sodium excretion, accompanied by increased heart rate and heart rate variability, secondary to increased activity of the sympathetic nervous system. Read More

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http://dx.doi.org/10.1042/CS20190254DOI Listing

Protective cardiac conditioning by an atypical cytokine.

Clin Sci (Lond) 2019 Apr 18;133(8):933-937. Epub 2019 Apr 18.

Chair of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich 81377, Germany

Ischemic heart disease (IHD) represents the leading cause of morbidity and mortality worldwide. Therapy options generally aim at restoring the blood flow to the heart muscle and relieve the ischemic insult. Paradoxically, coronary artery reperfusion itself, both during emergency intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20190036
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http://dx.doi.org/10.1042/CS20190036DOI Listing
April 2019
1 Read

circRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/ IGF-1R axis.

Clin Sci (Lond) 2019 Apr 16. Epub 2019 Apr 16.

The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

Background: Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. However, the molecular mechanisms that link circRNAs with Laryngeal squamous cell carcinoma (LSCC) are not well understood. In the present study, we attempted to provide novel basis for targeted therapy for LSCC from the aspect of circRNA-miRNA-mRNA interaction. Read More

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http://dx.doi.org/10.1042/CS20190110DOI Listing

Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?

Clin Sci (Lond) 2019 Apr 2;133(7):805-819. Epub 2019 Apr 2.

Department of Translational Medical Sciences, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy.

Autophagy is a conserved process by which cytoplasmatic elements are sequestered in vesicles and degraded after their fusion with lysosomes, thus recycling the precursor molecules. The autophagy-mediated removal of redundant/harmful/damaged organelles and biomolecules plays not only a replenishing function, but protects against stressful conditions through an adaptive mechanism. Autophagy, known to play a role in several pathological conditions, is now gaining increasing attention also in the perspective of the identification of the pathogenetic mechanisms at the basis of ascending thoracic aortic aneurysm (TAA), a localized or diffused dilatation of the aorta with an abnormal widening greater than 50 percent of the vessel's normal diameter. Read More

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http://dx.doi.org/10.1042/CS20181092DOI Listing
April 2019
1 Read

The human duodenal mucosa harbours all components for a local renin angiotensin system.

Clin Sci (Lond) 2019 Apr 15. Epub 2019 Apr 15.

Dept of Gastrosurgical Research & Education, Sahlgrenska University Hospital, Gothenburg, Sweden

Background: The renin-angiotensin system (RAS) is present in the gastrointestinal tract but remains to be fully characterized, particularly in man. The duodenum plays a role in both the upper and lower gastrointestinal regulation, as well in distant organs. This study investigates the presence and functional potential of RAS in the human duodenal mucosa of healthy individuals. Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20180877
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http://dx.doi.org/10.1042/CS20180877DOI Listing
April 2019
2 Reads

Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy.

Clin Sci (Lond) 2019 Apr 15. Epub 2019 Apr 15.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, People' s Republic of China, Guangzhou, China

Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients. Endothelial cell-derived small extracellular vesicles (sEVs) are important mediators of intercellular communication in the pathogenesis of several diseases. However, the exact mechanisms of wound healing mediated by endothelial cell-derived sEVs remain unclear. Read More

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http://dx.doi.org/10.1042/CS20190008DOI Listing
April 2019
1 Read

Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs.

Clin Sci (Lond) 2019 Apr 15. Epub 2019 Apr 15.

Physiology, University of Tennessee Health Science Center, 956 Court Ave, Suite C211 Coleman Bldg, Memphis, Tennessee, 38163, United States

Renal vasoconstriction, an early manifestation of ischemic acute kidney injury (AKI) results in renal hypoperfusion and a rapid decline in kidney function. The pathophysiological mechanisms that underlie ischemia-reperfusion (IR)-induced renal insufficiency are poorly understood, but possibilities include alterations in ion channel-dependent renal vasoregulation. In this study, we show that pharmacological activation of TRPV4 channels constricted preglomerular microvessels and elicited renal hypoperfusion in neonatal pigs. Read More

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http://dx.doi.org/10.1042/CS20180815DOI Listing
April 2019
1 Read

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease.

Clin Sci (Lond) 2019 Apr 12;133(7):885-904. Epub 2019 Apr 12.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia

Chronic obstructive pulmonary disease (COPD) is a disease characterised by persistent airflow limitation that is not fully reversible and is currently the fourth leading cause of death globally. It is now well established that cardiovascular-related comorbidities contribute to morbidity and mortality in COPD, with approximately 50% of deaths in COPD patients attributed to a cardiovascular event (e.g. Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20180316
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http://dx.doi.org/10.1042/CS20180316DOI Listing
April 2019
4 Reads

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats.

Clin Sci (Lond) 2019 Apr 12. Epub 2019 Apr 12.

Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, United States.

Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p. Read More

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http://dx.doi.org/10.1042/CS20180728DOI Listing
April 2019
2 Reads

Gut microbiota in obstructive sleep apnea-hypopnea syndrome: disease-related dysbiosis and metabolic comorbidities.

Clin Sci (Lond) 2019 Apr 12;133(7):905-917. Epub 2019 Apr 12.

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China

Gut microbiota alterations manifest as intermittent hypoxia and fragmented sleep, thereby mimicking obstructive sleep apnea-hypopnea syndrome (OSAHS). Here, we sought to perform the first direct survey of gut microbial dysbiosis over a range of apnea-hypopnea indices (AHI) among patients with OSAHS. We obtained fecal samples from 93 patients with OSAHS [5 < AHI ≤ 15 (=40), 15 < AHI ≤ 30 (=23), and AHI ≥ 30 (=30)] and 20 controls (AHI ≤ 5) and determined the microbiome composition via 16S rRNA pyrosequencing and bioinformatics analysis of variable regions 3-4. Read More

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http://dx.doi.org/10.1042/CS20180891DOI Listing
April 2019
1 Read

Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients.

Clin Sci (Lond) 2019 Apr 5. Epub 2019 Apr 5.

INIM Research Group, Hospital Universitari Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, 43007, Spain.

The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive cART. Integrated data from NMR-based lipoprotein profiles, MS-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. Read More

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http://dx.doi.org/10.1042/CS20190111DOI Listing

Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL33/ST2 signaling axis.

Clin Sci (Lond) 2019 Apr 5. Epub 2019 Apr 5.

Thoracic Medicine and Surgery, Temple University, 1157 MERB, 3500 N Broad Street, 3500 N Broad Street, Philadelphia, Pennsylvania, 19140, United States

Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not well-known.   Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b+/CD11c+), and CD8+ T cells, and progression of emphysema.  In this study, we examined the mechanisms underlying the RV-induced persistent inflammation and progression of emphysema in mice with COPD phenotype. Read More

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http://dx.doi.org/10.1042/CS20181088DOI Listing
April 2019
2 Reads
5.598 Impact Factor

Role of Orexin-B/Orexin 2 receptor in myocardial protection.

Clin Sci (Lond) 2019 Apr 4;133(7):853-857. Epub 2019 Apr 4.

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Pozzuoli (NA), Italy

Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function. This is of special relevance considering that cardiovascular diseases, including myocardial infarction and heart failure, are one of the major causes of mortality in the world. Read More

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http://dx.doi.org/10.1042/CS20181036DOI Listing
April 2019
4 Reads

A pan-RAF inhibitor LY3009120 inhibits necroptosis by preventing phosphorylation of RIPK1 and alleviates dextran sulfate sodium-induced colitis.

Clin Sci (Lond) 2019 Apr 16;133(8):919-932. Epub 2019 Apr 16.

The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy and Clinical Immunology, Guangzhou Medical University, Guangzhou 510260, China

A dramatic increase in the incidence of inflammatory bowel disease (IBD) has been observed in the past two decades, mainly in developed countries and also in developing regions. Necroptosis has been found to play an important role in the pathogenesis of IBD, suggesting its inhibitors are promising in clinic. However, clinical drugs targeting necroptosis are seriously lacking. Read More

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http://dx.doi.org/10.1042/CS20181081DOI Listing

Interleukin-35 promotes early endothelialization after stent implantation by regulating macrophage activation.

Clin Sci (Lond) 2019 Apr 8;133(7):869-884. Epub 2019 Apr 8.

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Early strut coverage after sirolimus-eluting stent (SES) implantation is associated with the activation of inflammation, but the underlying mechanisms are not completely understood. The present study aimed to identify the relationship between the anti-inflammatory cytokine interleukin (IL) 35 (IL-35) and early strut coverage and We utilized a retrospective study design to measure IL-35 levels in 68 stents from 68 patients with coronary artery disease and recorded serial optical coherence tomography (OCT) images (0 and 3 months) to assess stent endothelialization. The mechanism underlying the regulatory effects of IL-35 on macrophages and human umbilical vein endothelial cells (HUVECs) was also investigated. Read More

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http://dx.doi.org/10.1042/CS20180879DOI Listing

Cell-surface Translocation of Annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.

Clin Sci (Lond) 2019 Mar 22. Epub 2019 Mar 22.

Chengdu Medical College, Chengdu, China

Bleomycin, a widely used anti-cancer drug, may give rise to pulmonary fibrosis, a serious side effect which is associated with significant morbidity and mortality. Despite the intensive efforts, the precise pathogenic mechanisms of pulmonary fibrosis still remain to be clarified. Our previous study showed that bleomycin bound directly to annexin A2 (ANXA2, or p36), leading to development of pulmonary fibrosis by impeding TFEB-induced autophagic flux. Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20180687
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http://dx.doi.org/10.1042/CS20180687DOI Listing
March 2019
4 Reads

Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections.

Clin Sci (Lond) 2019 04 4;133(7):859-867. Epub 2019 Apr 4.

The Wadsworth Center, New York State Department of Health, Albany, New York, U.S.A.

Zika (ZIKV) and dengue (DENV) virus infections elicit a robust but cross-reactive antibody response against the viral envelope protein, while antibody responses against non-structural proteins (NS) are more virus specific. Building on this premise, we have previously developed a flavivirus multiplex microsphere immunoassay (MIA) for the serologic diagnosis of ZIKV and DENV infections. This assay significantly improved diagnostic accuracy; however, MIA could not differentiate more recent from past infections, which still represents a major diagnostic challenge. Read More

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http://dx.doi.org/10.1042/CS20180874DOI Listing
April 2019
1 Read

Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk.

Clin Sci (Lond) 2019 Apr 4;133(7):839-851. Epub 2019 Apr 4.

Department of Biochemical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, U.K.

We have reported the existence of a distinct neutrophil phenotype in giant cell arteritis (GCA) patients arising at week 24 of steroid treatment. In the present study, we investigated whether longitudinal analysis of neutrophil phenotype in patients with polymyalgia rheumatica (PMR) could reveal a novel association with disease status and immune cell cross-talk. Thus, we monitored PMR patient neutrophil phenotype and plasma microvesicle (MV) profiles in blood aliquots collected pre-steroid, and then at weeks 1, 4, 12 and 24 post-steroid treatment. Read More

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http://dx.doi.org/10.1042/CS20180415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449535PMC
April 2019
2 Reads

Potential therapeutic targets for atherosclerosis in sphingolipid metabolism.

Clin Sci (Lond) 2019 Mar 19;133(6):763-776. Epub 2019 Mar 19.

Department of Neurology, Peking University First Hospital, Beijing, China

Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism. Read More

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http://dx.doi.org/10.1042/CS20180911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422862PMC

Response to the letter regarding the hypothesis paper "Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema".

Clin Sci (Lond) 2019 Mar 19;133(6):761. Epub 2019 Mar 19.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.

This short article provides a comment on the recent letter by G. Bhave regarding our hypothesis paper [Clinical Science (2018) 132, 2609-2613]. Read More

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http://dx.doi.org/10.1042/CS20190154DOI Listing
March 2019
1 Read

Immunological abnormalities in patients with primary biliary cholangitis.

Clin Sci (Lond) 2019 Mar 19;133(6):741-760. Epub 2019 Mar 19.

College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi Province, China

Primary biliary cholangitis (PBC), an autoimmune liver disease occurring predominantly in women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and progressive intrahepatic cholestasis. The immune system plays a critical role in PBC pathogenesis and a variety of immune cell subsets have been shown to infiltrate the portal tract areas of patients with PBC. Amongst the participating immune cells, CD4 T cells are important cytokine-producing cells that foster an inflammatory microenvironment. Read More

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http://dx.doi.org/10.1042/CS20181123DOI Listing
March 2019
1 Read

Quantitating excess tissue sodium.

Authors:
Gautam Bhave

Clin Sci (Lond) 2019 Mar 19;133(6):739-740. Epub 2019 Mar 19.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, U.S.A.

Using changes in tissue [Na] concentration alone as done with Na MRI may not accurately quantitate excess tissue Na, particularly in cellular tissues. However, individually quantitating alterations in tissue Na and water content as possible with ashing studies may still accurately quantitate excess tissue Na in these situations. Furthermore, when tissue [Na] exceeds plasma [Na], excess tissue Na must be present. Read More

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http://dx.doi.org/10.1042/CS20190037DOI Listing
March 2019
1 Read

The emerging role of sorting nexins in cardiovascular diseases.

Clin Sci (Lond) 2019 Mar 15;133(5):723-737. Epub 2019 Mar 15.

Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing 400042, P.R. China

The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1042/CS20190034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418407PMC

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus.

Clin Sci (Lond) 2019 Mar 14. Epub 2019 Mar 14.

Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University; Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University; Institute of Translational and Stratified Medicine, Plymouth University Faculty of Medicine and Dentistry., Plymouth, United Kingdom.

Intestinal dysbiosis is implicated in Systemic lupus erythematosus (SLE). However, the evidence of gut microbiome changes in SLE is limited, and the association of changed gut microbiome with the activity of SLE, as well as its functional relevance with SLE still remains unknown. Here, we sequenced 16S rRNA amplicon on fecal samples from 40 SLE patients (19 active patients, 21 remissive patients), 20 disease controls (Rheumatoid Arthritis patients), and 22 healthy controls, and investigated the association of functional categories with taxonomic composition by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). Read More

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http://dx.doi.org/10.1042/CS20180841DOI Listing
March 2019
2 Reads
5.598 Impact Factor

Metabolomic analysis reveals metabolic characteristics of children with short stature caused by growth hormone deficiency.

Clin Sci (Lond) 2019 Mar 25;133(6):777-788. Epub 2019 Mar 25.

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, China

The diagnosis of short stature (SS) is of widespread importance for later treatment. In the present paper, a metabolomic method was used to analyze the metabolic characteristics of SS children caused by endocrine metabolic diseases in order to understand the underlying biochemical mechanism and provide a potential intervention strategy for SS. According to the clinical diagnosis and family investigation, all patients with SS were confirmed to be due to the endocrine disorders, especially GH deficiency (GHD). Read More

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http://dx.doi.org/10.1042/CS20181005DOI Listing
March 2019
1 Read

Recent developments in genetic/genomic medicine.

Clin Sci (Lond) 2019 Mar 5;133(5):697-708. Epub 2019 Mar 5.

Clinical Ethics and Law, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

Advances in genetic technology are having a major impact in the clinic, and mean that many perceptions of the role and scope of genetic testing are having to change. Genomic testing brings with it a greater opportunity for diagnosis, or predictions of future diagnoses, but also an increased chance of uncertain or unexpected findings, many of which may have impacts for multiple members of a person's family. In the past, genetic testing was rarely able to provide rapid results, but the increasing speed and availability of genomic testing is changing this, meaning that genomic information is increasingly influencing decisions around patient care in the acute inpatient setting. Read More

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http://dx.doi.org/10.1042/CS20180436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399103PMC

Melatonin suppresses lung cancer metastasis by inhibition of epithelial-mesenchymal transition through targeting to Twist.

Clin Sci (Lond) 2019 Mar 15;133(5):709-722. Epub 2019 Mar 15.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan

The epithelial-mesenchymal transition (EMT) phenotype, whereby mature epithelial cells undergo phenotype transition and differentiate into motile, invasive cells, has been indicated in tumor metastasis. The melatonin hormone secreted by the pineal gland has an antioxidant effect and protects cells against carcinogenic substances that reduce tumor progression. However, the effects of melatonin in EMT and lung cancer metastasis are largely unknown. Read More

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http://dx.doi.org/10.1042/CS20180945DOI Listing
March 2019
1 Read
5.598 Impact Factor

Macrophage migration inhibitory factor plays an essential role in ischemic preconditioning-mediated cardioprotection.

Clin Sci (Lond) 2019 Mar 5;133(5):665-680. Epub 2019 Mar 5.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

Ischemic preconditioning (IPC) is an endogenous protection strategy against myocardial ischemia-reperfusion (I/R) injury. Macrophage migration inhibitory factor (MIF) released from the myocardium subjected to brief periods of ischemia confers cardioprotection. We hypothesized that MIF plays an essential role in IPC-induced cardioprotection. Read More

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http://dx.doi.org/10.1042/CS20181013DOI Listing
March 2019
6 Reads

The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma.

Clin Sci (Lond) 2019 Mar 5;133(5):681-695. Epub 2019 Mar 5.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-Sen University, 510080 Guangzhou, Guangdong, P. R. China

Chemerin, which is encoded by retinoic acid receptor responder 2 (RARRES2), has been found to be related to malignant tumours, but its role in the development of oral squamous cell carcinoma (OSCC) is largely unexplored. In the present study, a higher serum level of chemerin was evident in patients with OSCC than in healthy individuals, and this high level of chemerin significantly decreased after tumour resection. In addition, high chemerin levels were positively associated with advanced tumour stage and lymph node metastasis. Read More

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http://dx.doi.org/10.1042/CS20181023DOI Listing

Histone acetylation and DNA methylation in ischemia/reperfusion injury.

Clin Sci (Lond) 2019 Feb 25;133(4):597-609. Epub 2019 Feb 25.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China

Ischemic/reperfusion (I/R) injury causes a series of serious clinical problems associated with high morbidity and mortality in various disorders, such as acute kidney injury (AKI), myocardial infarction, ischemic stroke, circulatory arrest, and peripheral vascular disease. The pathophysiology and pathogenesis of I/R injury is complex and multifactorial. Recent studies have revealed that epigenetic regulation is critically involved in the pathogenesis of I/R-induced tissue injury. Read More

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http://dx.doi.org/10.1042/CS20180465DOI Listing
February 2019
3 Reads

FNDC5/Irisin inhibits pathological cardiac hypertrophy.

Clin Sci (Lond) 2019 Mar 1;133(5):611-627. Epub 2019 Mar 1.

Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China

Cardiac hypertrophy is a common pathophysiological process in various cardiovascular diseases, which still has no effective therapies. Irisin is a novel myokine mainly secreted by skeletal muscle and is believed to be involved in the regulation of energy metabolism. In the present study, we found that irisin expression was elevated in hypertrophic murine hearts and serum. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20190016
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http://dx.doi.org/10.1042/CS20190016DOI Listing
March 2019
14 Reads

STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.

Clin Sci (Lond) 2019 Mar 1;133(5):645-663. Epub 2019 Mar 1.

Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, No. 150, Haping Road, Nangang District, Harbin 150001, China

Forkhead box protein M1 (FOXM1) was identified as an oncogenic transcription factor and master regulator of tumor progression and metastasis. FOXM1 expression often correlates with poor prognosis and chemotherapy resistance. In the present study, we investigated the association of FOXM1 expression and chemoresistance in pancreatic cancer. Read More

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http://dx.doi.org/10.1042/CS20180816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395369PMC
March 2019
4 Reads

is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

Clin Sci (Lond) 2019 Feb 22;133(4):583-595. Epub 2019 Feb 22.

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic target for the treatment of atherosclerosis. Here, we show that , which encodes a microtubule-severing protein called SPASTIN, was a novel target gene of in human. Actually, the miR-33 binding site in the 3'-UTR is conserved not in mice but in mid to large mammals, and it is impossible to clarify the role of on in mice. Read More

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http://dx.doi.org/10.1042/CS20180980DOI Listing
February 2019
4 Reads

MKP2 suppresses TGF-β1-induced epithelial-to-mesenchymal transition through JNK inhibition.

Authors:
Ivonne Loeffler

Clin Sci (Lond) 2019 Feb 13;133(3):545-550. Epub 2019 Feb 13.

Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany

Interstitial fibrosis is a typical feature of end-stage renal diseases, regardless of the initial cause of kidney injury. Epithelial-to-mesenchymal transition (EMT) is a mechanism that is thought to play a role in generating the interstitial matrix-producing myofibroblasts and is prominently induced by the transforming growth factor-β 1 (TGF-β1). TGF-β1 signals through a variety of Smad and non-Smad signaling pathways, including the mitogen-activated protein kinase (MAPK) pathways. Read More

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http://dx.doi.org/10.1042/CS20180881DOI Listing
February 2019
1 Read

Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!

Clin Sci (Lond) 2019 Feb 12;133(3):465-481. Epub 2019 Feb 12.

Laboratory of Hepato-Gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain (UCLouvain), Brussels, Belgium

Skeletal muscle is a tissue that represents 30-40% of total body mass in healthy humans and contains up to 75% of total body proteins. It is thus the largest organ in non-obese subjects. The past few years have seen increasing awareness of the prognostic value of appreciating changes in skeletal muscle compartment in various chronic diseases. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20180421
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http://dx.doi.org/10.1042/CS20180421DOI Listing
February 2019
6 Reads

The first identified heterozygous nonsense mutations in podocalyxin offer new perspectives on the biology of podocytopathies.

Clin Sci (Lond) 2019 Feb 8;133(3):443-447. Epub 2019 Feb 8.

The Biomedical Research Centre, University of British Columbia, Vancouver, Canada

In the last two decades, our understanding of the genetic underpinnings of inherited podocytopathies has advanced immensely. By sequencing the genomes of a large pool of families affected by focal segmental glomerulosclerosis (FSGS), researchers have identified a common theme: familial podocytopathies are frequently caused by genes selectively expressed in podocytes. Podocalyxin is a podocyte-specific surface sialomucin that has long been known to play important roles in podocyte morphogenesis and function. Read More

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http://dx.doi.org/10.1042/CS20181067DOI Listing
February 2019
2 Reads

Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice.

Clin Sci (Lond) 2019 03 1;133(5):629-643. Epub 2019 Mar 1.

Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.

The renin-angiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala-angiotensin-(1-7)) is a new biologically active peptide from the RAS, interacting with Mas-related G-protein-coupled receptor member D. Although a growing number of studies reveal the cardioprotective effects of alamandine, there is a paucity of data on its participation in vascular remodelling associated events. Read More

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http://dx.doi.org/10.1042/CS20180547DOI Listing

Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.

Clin Sci (Lond) 2019 Feb 18;133(4):551-564. Epub 2019 Feb 18.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia

Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established that an exaggerated inflammatory and oxidative stress response to cigarette smoke (CS) leads to, emphysema, small airway fibrosis, mucus hypersecretion, and progressive airflow limitation. Current treatments have limited efficacy in inhibiting chronic inflammation and consequently do not reverse the pathology that initiates and drives the long-term progression of disease. Read More

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http://dx.doi.org/10.1042/CS20180912DOI Listing
February 2019
8 Reads

Activation of G protein-coupled estrogen receptor protects intestine from ischemia/reperfusion injury in mice by protecting the crypt cell proliferation.

Clin Sci (Lond) 2019 Feb 8;133(3):449-464. Epub 2019 Feb 8.

Department of Physiology and Pathohysiology, School of Basic Medical Science, Shandong University, Jinan 250012, China

The intestinal ischemia/reperfusion (I/R) injury is a common clinical event related with high mortality in patients undergoing surgery or trauma. Estrogen exerts salutary effect on intestinal I/R injury, but the receptor type is not totally understood. We aimed to identify whether the G protein-coupled estrogen receptor (GPER) could protect the intestine against I/R injury and explored the mechanism. Read More

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http://dx.doi.org/10.1042/CS20180919DOI Listing
February 2019
3 Reads
5.598 Impact Factor

Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia/reperfusion injury.

Clin Sci (Lond) 2019 Feb 12;133(3):497-513. Epub 2019 Feb 12.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

An uncontrolled balance of mitochondrial dynamics has been shown to contribute to cardiac dysfunction during ischemia/reperfusion (I/R) injury. Although inhibition of mitochondrial fission could ameliorate cardiac dysfunction, modulation of mitochondrial fusion by giving a fusion promoter at different time-points during cardiac I/R injury has never been investigated. We hypothesized that giving of a mitochondrial fusion promoter at different time-points exerts cardioprotection with different levels of efficacy in rats with cardiac I/R injury. Read More

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http://dx.doi.org/10.1042/CS20190014DOI Listing
February 2019

Omeprazole prevents CDX2 and SOX9 expression by inhibiting hedgehog signaling in Barrett's esophagus cells.

Clin Sci (Lond) 2019 Feb 12;133(3):483-495. Epub 2019 Feb 12.

State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China

Activation of hedgehog (Hh) signaling contributes to the progression of Barrett's esophagus (BE), which increases the risk of esophageal adenocarcinoma. Recent clinical studies revealed that proton-pump inhibitors (PPIs) but not H2 receptor antagonists (H2RAs) were associated with a decreased risk of esophageal adenocarcinoma. We would like to know whether PPIs interfere with BE progression during BE treatment. Read More

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http://dx.doi.org/10.1042/CS20180828DOI Listing
February 2019
8 Reads

Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation.

Clin Sci (Lond) 2019 Feb 12;133(3):515-530. Epub 2019 Feb 12.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China

The synthesis of serum amyloid A1 (SAA1) is augmented in human fetal membranes at parturition. However, its role in parturition remains largely unknown. Here, we investigated whether SAA1 was involved in the rupture of fetal membranes, a crucial event in parturition accompanied with extensive degradation of collagens. Read More

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http://dx.doi.org/10.1042/CS20180950DOI Listing
February 2019
1 Read

Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies.

Clin Sci (Lond) 2019 Jan 25;133(2):315-319. Epub 2019 Jan 25.

Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia

Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. Read More

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http://dx.doi.org/10.1042/CS20180901DOI Listing
January 2019
2 Reads
5.598 Impact Factor

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD).

Clin Sci (Lond) 2019 Jan 25;133(2):287-313. Epub 2019 Jan 25.

Pathophysiology of Diabetic Complications Laboratory, Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia

The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are currently no effective treatments available to sufficiently halt the progression of CKD towards renal failure. This is largely due to ongoing secondary pathological processes generally elicited by the onset of disease. Read More

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http://dx.doi.org/10.1042/CS20180438DOI Listing
January 2019
3 Reads

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).

Clin Sci (Lond) 2019 Jan 25;133(2):269-286. Epub 2019 Jan 25.

Philips Research Europe, High Tech Campus 34, 5656AE Eindhoven, The Netherlands

Increased PSA-based screening for prostate cancer has resulted in a growing number of diagnosed cases. However, around half of these are 'indolent', neither metastasizing nor leading to disease specific death. Treating non-progressing tumours with invasive therapies is currently regarded as unnecessary over-treatment with patients being considered for conservative regimens, such as active surveillance (AS). Read More

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http://dx.doi.org/10.1042/CS20180519DOI Listing
January 2019
1 Read

Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.

Clin Sci (Lond) 2019 Feb 5;133(3):425-441. Epub 2019 Feb 5.

State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

MiRNAs regulate the cardiomyocyte (CM) cell cycle at the post-transcriptional level, affect cell proliferation, and intervene in harmed CM repair post-injury. The present study was undertaken to characterize the role of let-7i-5p in the processes of CM cell cycle and proliferation and to reveal the mechanisms thereof. In the present study, we used real-time qPCR (RT-qPCR) to determine the up-regulated let-7i-5p in CMs during the postnatal switch from proliferation to terminal differentiation and further validated the role of let-7i-5p by loss- and gain-of-function of let-7i-5p in CMs and We found that the overexpression of let-7i-5p inhibited CM proliferation, whereas the suppression of let-7i-5p significantly facilitated CM proliferation. Read More

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http://dx.doi.org/10.1042/CS20181002DOI Listing
February 2019
1 Read

PCSK9 inhibition 2018: riding a new wave of coronary prevention.

Clin Sci (Lond) 2019 Jan 22;133(2):205-224. Epub 2019 Jan 22.

School of Medicine, University of Western Australia, Perth, Australia

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic enzyme that regulates the low-density lipoprotein cholesterol (LDL-c) receptor and thus circulating LDL-c levels. With overwhelming evidence now supporting the reduction in LDL-c to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal antibodies. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20171300
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http://dx.doi.org/10.1042/CS20171300DOI Listing
January 2019
17 Reads

Trained immunity and diabetic vascular disease.

Clin Sci (Lond) 2019 Jan 18;133(2):195-203. Epub 2019 Jan 18.

Department of Internal Medicine (463), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands

Trained immunity is a recently described phenomenon whereby innate immune cells undergo functional reprogramming in response to microbial products, vaccines, or other stimuli, leading them to mount a sensitized nonspecific response to subsequent stimulation. While it is essential for the host response to pathogens, many diseases are the product of excessive or chronic inflammation. Atherosclerosis is a disease characterized by chronic low-grade inflammation of the arterial wall leading to plaque formation, where macrophages are the most abundant cell regulating plaque progression and stability. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20180905
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http://dx.doi.org/10.1042/CS20180905DOI Listing
January 2019
29 Reads
5.598 Impact Factor