40,676 results match your criteria Clinical Schizophrenia & Related Psychoses [Journal]


Electroconvulsive Therapy for Neuroleptic Malignant Syndrome: A Case Series.

J ECT 2019 Apr 22. Epub 2019 Apr 22.

From the Michigan Medicine Department of Psychiatry, The University of Michigan, Ann Arbor, MI.

Objectives: Neuroleptic malignant syndrome (NMS) is an uncommon condition associated with significant morbidity and mortality. Data on treatment interventions are limited. In this case series, we sought to describe all NMS cases requiring ECT from a large academic institution over a nearly 2-decade period. Read More

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http://dx.doi.org/10.1097/YCT.0000000000000600DOI Listing

Effects of Olanzapine on Bone Mineral Density, Glucose, and Lipid Metabolism in Schizophrenia Patients.

Int J Endocrinol 2019 21;2019:1312804. Epub 2019 Mar 21.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Aim: To explore whether olanzapine alters bone mineral density (BMD), glucose, and lipid metabolism in schizophrenia patients.

Methods: This study enrolled 150 patients diagnosed with schizophrenia according to , including 101 patients who had over 6-month history of olanzapine use (olanzapine-treated group) and 49 patients who had no history of antipsychotic use (first episode drug-naïve group). 71 subjects with age- and gender-matched healthy volunteers (healthy control group) were also enrolled. Read More

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https://www.hindawi.com/journals/ije/2019/1312804/
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http://dx.doi.org/10.1155/2019/1312804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451798PMC
March 2019
1 Read

Structural and functional brain biomarkers of clinical response to rTMS of medication-resistant auditory hallucinations in schizophrenia patients: study protocol for a randomized sham-controlled double-blind clinical trial.

Trials 2019 Apr 23;20(1):229. Epub 2019 Apr 23.

Unité de Recherche Clinique, Établissement Public de Santé Ville-Evrard, 202 avenue Jean Jaurès, 93332, Neuilly-sur-Marne, France.

Background: The potential of non-invasive repetitive transcranial magnetic stimulation (rTMS) to improve auditory verbal hallucinations (AVH) in schizophrenia patients has been increasingly explored over the past decade. Despite highly promising results, high inter-individual variability of clinical response and ineffective outcomes in a significant number of patients underscored the need to identify factors associated with the clinical response to rTMS. It should help improve the efficacy of rTMS in patients with medication-resistant AVH, and allow a better understanding of its neural impact. Read More

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http://dx.doi.org/10.1186/s13063-019-3311-xDOI Listing

Correlates of Future Violence in People Being Treated for Schizophrenia.

Am J Psychiatry 2019 Apr 24:appiajp201918080909. Epub 2019 Apr 24.

The VA New England Mental Illness, Research, Education, and Clinical Center/VA Connecticut Healthcare System, West Haven, Conn. (Buchanan, Sint, Rosenheck); the Division of Law and Psychiatry, Yale School of Medicine, New Haven, Conn. (Buchanan); the Department of Psychiatry and Behavioral Sciences and the Division of Social and Community Psychiatry, Duke University School of Medicine, Durham, N.C. (Swanson); and the Departments of Psychiatry, Epidemiology, and Public Health and the Child Study Center, Yale University School of Medicine, West Haven, Conn. (Rosenheck).

Objective: Violent behavior is infrequent among individuals with schizophrenia but is clinically important. The purpose of this study was to provide data on the correlates of violence, which may allow better risk assessment and care.

Methods: A total of 1,435 individuals with schizophrenia who participated in the National Institute of Mental Health's Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study and were followed for 18 months were examined. Read More

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http://dx.doi.org/10.1176/appi.ajp.2019.18080909DOI Listing

Antipsychotic Adherence Intervention for Veterans over Forty with Schizophrenia: Results of a Pilot Study.

Clin Schizophr Relat Psychoses 2009 Jan;2(4):317-325

4 Veterans Administration San Diego Healthcare System and Advanced Center for Intervention and Services Research, University of California, San Diego.

This pilot study tested the feasibility, acceptability, and effect sizes of a multimodal, individual intervention designed to optimize antipsychotic medication use in patients ≥40 years of age with schizophrenia or schizoaffective disorder. We randomized forty patients into two groups: usual care (UC) versus a nine-session, manualized antipsychotic adherence intervention (AAI). The AAI attempted to improve adherence by combining three psychosocial techniques: 1) education; 2) skills training; and, 3) alliance building. Read More

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http://dx.doi.org/10.3371/CSRP.2.4.5DOI Listing
January 2009

Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial.

PLoS Med 2019 Apr 23;16(4):e1002785. Epub 2019 Apr 23.

Xiangya School of Public Health, Central South University, Changsha, Hunan, China.

Background: Schizophrenia is a leading cause of disability, and a shift from facility- to community-based care has been proposed to meet the resource challenges of mental healthcare in low- and middle-income countries. We hypothesized that the addition of mobile texting would improve schizophrenia care in a resource-poor community setting compared with a community-based free-medicine program alone.

Methods And Findings: In this 2-arm randomized controlled trial, 278 community-dwelling villagers (patient participants) were randomly selected from people with schizophrenia from 9 townships of Hunan, China, and were randomized 1:1 into 2 groups. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002785DOI Listing

No associations between medial temporal lobe volumes and verbal learning/memory in emerging psychosis.

Eur J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland.

Gray matter (GM) volume alterations have been repeatedly demonstrated in patients with first episode psychosis (FEP). Some of these neuroanatomical abnormalities are already evident in the at-risk mental state (ARMS) for psychosis. Not only GM alterations but also neurocognitive impairments predate the onset of frank psychosis with verbal learning and memory (VLM) being among the most impaired domains. Read More

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http://dx.doi.org/10.1111/ejn.14427DOI Listing

Continuity of care and clinical outcomes in the community for people with severe mental illness.

Br J Psychiatry 2019 May;214(5):273-278

Professor of Psychiatric Research,Institute of Psychiatry, Psychology and Neuroscience,King's College London,UK.

Background: High continuity of care is prized by users of mental health services and lauded in health policy. It is especially important in long-term conditions like schizophrenia. However, it is not routinely measured, and therefore not often evaluated when service reorganisations take place. Read More

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http://dx.doi.org/10.1192/bjp.2018.261DOI Listing

Progressive muscle relaxation for patients with chronic schizophrenia: A randomized controlled study.

Perspect Psychiatr Care 2019 Apr 22. Epub 2019 Apr 22.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

Purpose: To evaluate progressive muscle relaxation (PMR) as an intervention for anxiety, psychotic symptoms, and quality of life (QOL) in patients with chronic schizophrenia.

Design And Methods: Eighty patients were recruited from a Taiwanese psychiatry ward. The intervention group received group PMR; control group received treatment-as-usual. Read More

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http://dx.doi.org/10.1111/ppc.12384DOI Listing

Perceptions about mental illness among general practitioners.

Int J Ment Health Syst 2019 13;13:27. Epub 2019 Apr 13.

1Andalusian Group of Psychosocial Research (GAP), Department of Personality, Assessment and Psychological Treatment, University of Malaga, Campus Teatinos, Malaga, Spain.

Background: General practitioners (GPs) play an important role in the physical care of patients with severe mental illness, so our aim was to analyse the relationships between GPs' sociodemographic status and worked-related variables and their perceptions about mental illness.

Methods: A descriptive, cross-sectional study was conducted in the Clinical Management Unit of Mental Health (CMU-MH) of the Regional Hospital of Malaga (Spain). The eligible population comprised all GPs working in the 13 primary care centres (PCCs) in the hospital's catchment area during the study period. Read More

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http://dx.doi.org/10.1186/s13033-019-0284-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461815PMC

Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.

Transl Psychiatry 2019 Apr 22;9(1):126. Epub 2019 Apr 22.

Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

Although a number of studies have identified several convincing candidate genes or molecules, the pathophysiology of schizophrenia (SCZ) has not been completely elucidated. Therapeutic optimization based on pathophysiology should be performed as early as possible to improve functional outcomes and prognosis; to detect useful biomarkers for SCZ, which reflect pathophysiology and can be utilized for timely diagnosis and effective therapy. To explore biomarkers for SCZ, we employed fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) of lymphoblastoid cell lines (LCLs) (1st sample set: 30 SCZ and 30 CON). Read More

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http://dx.doi.org/10.1038/s41398-019-0461-2DOI Listing

Developmental social vulnerability as the intrinsic origin of psychopathology: A paradigm shift from disease entities to psychiatric derivatives within human diversity.

Med Hypotheses 2019 May 22;126:95-108. Epub 2019 Mar 22.

Department of Psychiatry, University of California at San Francisco, San Francisco, USA.

How a social episode is perceived by a person and how the experience affects her/his subsequent behaviors will inevitably and sometimes accidentally vary in each case on the developmental trajectory from the birth of consciousness to death. Both the preceding developmental conditions and the social impact of the episode become a starting point for the following states of human complex conditions, creating the extraordinary diversity that characterizes our complex society. In this evolutionarily carved landscape, genetic factors including stochastic epistasis, environmental modification, and gene-environment interactions are all active. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.015DOI Listing

The psycho-periodic cube.

Med Hypotheses 2019 May 23;126:69-77. Epub 2019 Mar 23.

Freelance Developer, İstanbul, Turkey.

The current diagnostic classification systems in psychiatry have been developed primarily for evidence-based clinical decision making with both categorical and dimensional approaches having their own advantages and disadvantages. Efforts have been made to improve these classification systems, and we are now at the point where we must expand beyond the one-dimensionality of these systems. In this paper, we propose that psychiatric disorders can be arranged in a three-dimensional classification system according to the degree of dysfunctions on three specific axes in a way that is similar to the arrangement of chemical elements according to their atomic weights in Mendeleyev's periodic table. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.020DOI Listing

The role of dopamine D3 receptors in the mechanism of action of cariprazine.

CNS Spectr 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pharmacological and Biomolecular Sciences,Università degli Studi di Milano,Milan,Italy.

Cariprazine is a new atypical antipsychotic drug (APD) with a unique pharmacodynamic profile, different from both typical and atypical APDs. Specifically, cariprazine acts as a partial agonist at the dopamine (DA) D2 and D3 receptors and serotonin 5-HT1A receptors, and as an antagonist at the 5-HT2B receptors. Moreover, it shows moderate affinities for adrenergic, histaminergic, and cholinergic receptors that are involved in mediating the side effects characteristic of typical APDs. Read More

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http://dx.doi.org/10.1017/S109285291900083XDOI Listing

Analysis of covariance (ANCOVA) in randomized trials: More precision and valid confidence intervals, without model assumptions.

Biometrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Maryland 21205, Baltimore, USA.

"Covariate adjustment" in the randomized trial context refers to an estimator of the average treatment effect that adjusts for chance imbalances between study arms in baseline variables (called "covariates"). The baseline variables could include, e.g. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13062
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http://dx.doi.org/10.1111/biom.13062DOI Listing
April 2019
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Strengths in patients with schizophrenia and healthy people - similarities and differences.

Psychiatr Pol 2019 Feb 28;53(1):93-104. Epub 2019 Feb 28.

Akademia Pedagogiki Specjalnej im. Marii Grzegorzewskiej, Instytut Psychologii.

Objectives: The aim of the study was to assess the character strengths of people with schizophrenia and their importance in building life satisfaction, and also to identify differences and similarities in the character strengths between people with schizophrenia and healthy people.

Methods: 40 people with diagnosed schizophrenia and 40 healthy people participated in the study. Each participant was examined with the following tools: Socio-Demographic Data Questionnaire, Satisfaction with Life Scale (SWLS), International Personality Item Pool - Values in Action (IPIP-VIA). Read More

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http://dx.doi.org/10.12740/PP/81109DOI Listing
February 2019

Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment.

Chronic Stress (Thousand Oaks) 2019 Jan-Feb;3. Epub 2019 Apr 15.

Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Background: In soldiers with posttraumatic stress disorder (PTSD), symptom provocation was found to induce increased connectivity within the salience network, as measured by functional magnetic resonance imaging (MRI) and global brain connectivity with global signal regression (GBCr). However, it is unknown whether these GBCr disturbances would normalize following effective PTSD treatment.

Methods: 69 US Army soldiers with (n = 42) and without PTSD (n = 27) completed MRI at rest and during symptom provocation using subject-specific script imagery. Read More

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http://dx.doi.org/10.1177/2470547019838971DOI Listing

[Regional differences in the incidence of affective disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):10-16

Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

Aim: To analyze the dynamics of the primary indicator of morbidity of affective psychotic and non-psychotic disorders.

Material And Methods: The article uses the data of State statistical observations for the period from 2005 to 2015 years. Regional (eight federal districts) primary indicators of diagnosis of mental disorders were subjected to epidemiological analysis in general, schizophrenia and mood disorders were analyzed in more detail. Read More

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http://dx.doi.org/10.17116/jnevro20191191210DOI Listing
January 2019
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Measuring empathy in schizophrenia: The Empathic Accuracy Task and its correlation with other empathy measures.

Schizophr Res 2019 Apr 18. Epub 2019 Apr 18.

University of Groningen, Department of Clinical Psychology and Experimental Psychopathology, Grote Kruisstraat 1/2, 9712 TS Groningen, the Netherlands; GGZ Noord-Drenthe, Department of Psychotic Disorders, Dennenweg 9, 9404 LA Assen, the Netherlands.

Introduction: Empathy is an interpersonal process impaired in schizophrenia. Past studies have mainly used questionnaires or performance-based tasks with static cues to measure cognitive and affective empathy. We used the Empathic Accuracy Task (EAT) designed to capture dynamic aspects of empathy by using videoclips in which perceivers continuously judge emotionally charged stories. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.024DOI Listing

Haloperidol discontinuation for people with schizophrenia.

Cochrane Database Syst Rev 2019 Apr 21;4:CD011408. Epub 2019 Apr 21.

Community Mental Health, Counties Manukau Health, Building 6, 17 Lambie Drive,, Manukau, Auckland, New Zealand, 2241.

Background: Schizophrenia is a disabling serious mental illness that can be chronic. Haloperidol, one of the first generation of antipsychotic drugs, is effective in the treatment of schizophrenia but can have adverse side effects. The effects of stopping haloperidol in people with schizophrenia who are stable on their prescription are not well researched in the context of systematic reviews. Read More

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http://dx.doi.org/10.1002/14651858.CD011408.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475523PMC
April 2019
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Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals.

Schizophr Res 2019 Apr 17. Epub 2019 Apr 17.

Neural Dynamics Laboratory, Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address:

The early auditory-evoked gamma band response (EAGBR) may serve as an index of the integrity of fast recurrent inhibition or synaptic connectivity in the auditory cortex, where abnormalities in individuals with schizophrenia have been consistently found. The EAGBR has been rarely investigated in first episode schizophrenia patients (FESZ) and individuals at clinical high risk (CHR) for schizophrenia, and never been compared directly between these populations nor evaluated longitudinally. Here we examined the EAGBR in FESZ, CHR, and matched healthy controls (HC) at baseline and 1-year follow-up assessments to determine whether the EAGBR was affected in these clinical groups, and whether any EAGBR abnormalities changed over time. Read More

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http://dx.doi.org/10.1016/j.schres.2019.03.025DOI Listing

Validation of the social functioning scale: Comparison and evaluation in early psychosis, autism spectrum disorder and social anxiety disorder.

Psychiatry Res 2019 Mar 26;276:45-55. Epub 2019 Mar 26.

Autism Clinic for Translational Research, Brain and Mind Centre, Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, Sydney, NSW 2050 Australia. Electronic address:

Social functioning is an important component of mental disorders for assessment and treatment. There is no recognised self-report instrument to measure social functioning across disorders where social impairment is significant. The Social Functioning Scale (SFS) has, however, been used to assess social functioning in psychotic disorders, including Schizophrenia and Early Psychosis. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.037DOI Listing

Empathy for others' pain is disrupted at the neurophysiological level in schizophrenia.

Br J Clin Psychol 2019 Apr 19. Epub 2019 Apr 19.

School of Psychology, University of Queensland, Brisbane, Queensland, Australia.

Objective: Previous research has shown that empathy for pain is disrupted at the neural level in people with schizophrenia. However, many of these studies have failed to assess key background contextual variables that have previously been linked to neurophysiological responding. Moreover, no study to date has examined the potential influence of schizotypal characteristics on neurophysiological responding in non-clinical individuals. Read More

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http://dx.doi.org/10.1111/bjc.12220DOI Listing

Food insecurity and work impairment in people with severe mental disorders in a rural district of Ethiopia: a cross-sectional survey.

Soc Psychiatry Psychiatr Epidemiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Purpose: In this study, we aimed to identify factors associated with severe food insecurity and work impairment in people with severe mental disorders (SMD) in a rural African setting, with a view to identifying potential areas for intervention.

Methods: A community-based, cross-sectional survey was conducted in Sodo district, south central Ethiopia. Key informant-identified people with possible SMD were referred for assessment by trained primary care workers and received confirmatory psychiatric diagnoses from psychiatric nurses using a standardized clinical interview. Read More

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http://link.springer.com/10.1007/s00127-019-01709-7
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http://dx.doi.org/10.1007/s00127-019-01709-7DOI Listing
April 2019
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Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.

Schizophrenia has been conceived as a disorder of brain connectivity, but it is unclear how this network phenotype is related to the underlying genetics. We used morphometric similarity analysis of MRI data as a marker of interareal cortical connectivity in three prior case-control studies of psychosis: in total, = 185 cases and = 227 controls. Psychosis was associated with globally reduced morphometric similarity in all three studies. Read More

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http://dx.doi.org/10.1073/pnas.1820754116DOI Listing

Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts.

Biol Psychiatry 2019 Mar 13. Epub 2019 Mar 13.

Department of Genetics, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Major depressive disorder (MDD) is moderately heritable, with a high prevalence and a presumed high heterogeneity. Copy number variants (CNVs) could contribute to the heritable component of risk, but the two previous genome-wide association studies of rare CNVs did not report significant findings.

Methods: In this meta-analysis of four cohorts (5780 patients and 6626 control subjects), we analyzed the association of MDD to 1) genome-wide burden of rare deletions and duplications, partitioned by length (<100 kb or >100 kb) and other characteristics, and 2) individual rare exonic CNVs and CNV regions. Read More

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http://dx.doi.org/10.1016/j.biopsych.2019.02.022DOI Listing
March 2019
3 Reads

Clinical Characteristics of Obstructive Sleep Apnea in Psychiatric Disease.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

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https://www.mdpi.com/2077-0383/8/4/534
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http://dx.doi.org/10.3390/jcm8040534DOI Listing
April 2019
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Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data.

Front Psychol 2019 2;10:689. Epub 2019 Apr 2.

National Institute of Mental Health, Klecany, Czechia.

The character of cognitive deficit in schizophrenia is not clear due to the heterogeneity in research results. In heterogeneous conditions, the cluster solution allows the classification of individuals based on profiles. Our aim was to examine the cognitive profiles of first-episode schizophrenia spectrum disorder (FES) subjects based on cluster analysis, and to correlate these profiles with clinical variables and resting state brain connectivity, as measured with magnetic resonance imaging. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2019.00689
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http://dx.doi.org/10.3389/fpsyg.2019.00689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454196PMC
April 2019
1 Read

Schizophrenia and Bipolar Illness in the Relatives of University Scientists: An Epidemiological Report on the Creativity-Psychopathology Relationship.

Front Psychiatry 2019 2;10:175. Epub 2019 Apr 2.

Mental Health Center Amager, Copenhagen, Denmark.

A potential link between creativity and mental illness has been a longstanding topic for human studies and empirical research. The major problem is defining creativity and establishing its measurable indicators. A few high-quality epidemiological studies have been undertaken and point to a link between creativity and vulnerability to mental illness. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454109PMC

Adult Mental Health Outpatients Who Have Minor Children: Prevalence of Parents, Referrals of Their Children, and Patient Characteristics.

Front Psychiatry 2019 2;10:163. Epub 2019 Apr 2.

Health Services Research, SINTEF, Trondheim, Norway.

A strong connection exists between parental mental illness and lifetime mental health risk for their children. Thus, it is important to determine, when parents attend for treatment for their illness, the prevalence and characteristics of parents with a mental illness and identify referral actions for their children. Previous studies indicate that 12-45% of adult mental health service patients are parents with minor children. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456127PMC

EEG changes in patients on antipsychotic therapy: A systematic review.

Epilepsy Behav 2019 Apr 15;95:1-9. Epub 2019 Apr 15.

Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: The objective of the study was to characterize the electroencephalogram (EEG) changes associated with different antipsychotic medications based on the evidence from the literature.

Methods: A systematic search of the databases Medline, PsycINFO, and PubMed was conducted. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this systematic review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183104
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http://dx.doi.org/10.1016/j.yebeh.2019.02.005DOI Listing
April 2019
3 Reads

Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations.

J Affect Disord 2019 Apr 9;252:350-357. Epub 2019 Apr 9.

Research and Knowledge Center, The Danish Veteran Center, Garnisonen 1, 4100 Ringsted, Denmark.

Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder that occurs with relatively high frequency after deployment to warzones (∼10%). While twin studies have estimated the heritability to be up to 40%, thus indicating a considerable genetic component in the etiology, the biological mechanisms underlying risk and development of PTSD remain unknown.

Methods: Here, we conduct a genome-wide association study (GWAS; N = 2,481) to identify genome regions that associate with PTSD in a highly homogenous, trauma-exposed sample of Danish soldiers deployed to war and conflict zones. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.070DOI Listing
April 2019
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Blonanserin ameliorates social deficit through dopamine-D receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.

Neurochem Int 2019 Apr 15. Epub 2019 Apr 15.

Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Nagoya, 468-8503, Japan; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan. Electronic address:

Blonanserin differs from other antipsychotic drugs, such as risperidone and olanzapine and exhibits a higher affinity for dopamine-D receptors than for serotonin 5-HT receptors. We investigated the involvement of dopamine-D receptors in the effect of blonanserin on the social deficit observed in an animal model of schizophrenia and sought to elucidate the molecular mechanism underlying its action. Mice received phencyclidine (PCP: 10 mg/kg/day, s. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.008DOI Listing

Concomitant use of alcohol and benzodiazepine hypnotics in psychiatric outpatients: a cross-sectional survey.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Concomitant use of benzodiazepines and alcohol appears prevalent in a clinical setting. The objectives of this study were as follows: (1) to investigate the prevalence of concomitant use of benzodiazepine hypnotics and alcohol in psychiatric outpatients, (2) to examine the clinical characteristics and factors associated with the concomitant use, and (3) to investigate the awareness of the psychiatrists-in-charge about the concomitant use. Outpatients with schizophrenia, depression, and insomnia who were receiving benzodiazepine hypnotics were asked to fill in a sleeping diary for seven consecutive days in which use of hypnotics and alcohol was also recorded. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000264DOI Listing
April 2019
2 Reads

A simple formula for enumerating comparisons in trials and network meta-analysis.

F1000Res 2019 9;8:38. Epub 2019 Jan 9.

Cochrane Schizophrenia Group, Division of Psychiatry and Applied Psychology, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, NG7 2TU, UK.

We present use of a simple formula to calculate the number of pairwise comparisons of interventions within a single trial or network meta-analyses. We used the data from our previous network meta-analysis to build a study-based register and enumerated the direct pairwise comparisons from the trials therein. We then compared this with the number of comparisons predicted by use of the formula and finally with the reported number of comparisons (indirect or direct) within the network meta-analysis. Read More

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http://dx.doi.org/10.12688/f1000research.17352.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402080.2PMC
January 2019
1 Read

Update on ERbeta.

J Steroid Biochem Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States.

ERbeta (ERβ) celebrated its 20th birthday in 2016 and although the overwhelming data in the literature indicate a role for this receptor in the control of epithelial proliferation, neurodegeneration and immune function, no ERβ agonists have yet made it to the clinics. This is the situation, despite the fact that very good safe ERβ agonists have been synthesized and at least one has been donated to the NIH for distribution to researchers, who want to study its possible clinical use. Clinical trials are ongoing for the use of ERβ agonists in prostate cancer and schizophrenia but even today reviewers of our grants still make comments like "The grant is excellent except that the focus of the grant is ERβ". Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.007DOI Listing
April 2019
2 Reads

Association of Rare Copy Number Variants With Risk of Depression.

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Importance: The role of large, rare copy number variants (CNVs) in neuropsychiatric disorders is well established, but their association with common psychiatric disorders, such as depression, remains unclear.

Objective: To examine the association of a group of 53 CNVs associated with neurodevelopmental disorders and burden of rare CNVs with risk of depression.

Design, Setting, And Participants: This case-control study used data from the UK Biobank study sample, which comprised 502 534 individuals living in the United Kingdom. Read More

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http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapsychiatry.2019.0566DOI Listing
April 2019
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Efficacy and safety of paliperidone palmitate 3-month formulation in Latin American patients with schizophrenia: A subgroup analysis of data from two large phase 3 randomized, double-blind studies.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Janssen-Cilag UK, Buckinghamshire, UK.

Objective: To analyze the efficacy and safety of paliperidone palmitate 3-monthly (PP3M) in Latin American patients with schizophrenia vs. rest-of-world (ROW).

Methods: We analyzed data from two multinational, double-blind (DB), randomized, controlled phase 3 studies including patients with schizophrenia (DSM-IV-TR) previously stabilized on PP1M/PP3M (open-label [OL] phase). Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0153DOI Listing
April 2019
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Position and size of massa intermedia in Serbian brains.

Folia Morphol (Warsz) 2019 Apr 17. Epub 2019 Apr 17.

Medical Faculty, University of Nis, Bul. Zorana Djindjica 81, 18000 Nis, Serbia and Montenegro.

Background: Massa intermedia, a midline bar-shaped structure, connects two thalami across the third ventricle in 70-80% of healthy humans. It has become clinically important since its absence was comprehended as a midline malformation of the brain and brought in connection with schizophrenia indicating that some symptoms could be a consequence of disturbed neuron chains underlying the mechanisms of attention and processing of information. The aim of the investigation was to find out the incidence, position, and size of massa intermedia in the brains of the Serbian population. Read More

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http://dx.doi.org/10.5603/FM.a2019.0046DOI Listing
April 2019
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Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia.

Curr Top Behav Neurosci 2019 Apr 17. Epub 2019 Apr 17.

School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

In recent years, there is a new optimism in schizophrenia therapeutics with the emergence of immunomodulation as a potential treatment approach. Current evidence points to various immunological abnormalities in schizophrenia, including cell-mediated processes, acute phase proteins, cytokines, and intracellular mediators. Trait- and state-related immune dysfunction appears to exist, and a strong case can therefore be made for immunomodulation therapies in the prevention, treatment, and/or moderating the course of schizophrenia. Read More

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http://dx.doi.org/10.1007/7854_2019_91DOI Listing
April 2019
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Development and evaluation of Intensive Case Management Screening Sheet in the Japanese population.

Int J Ment Health Syst 2019 5;13:22. Epub 2019 Apr 5.

1Department of Community Mental Health and Law, National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), 4-1-1, Ogawahigashi, Kodaira, Tokyo Japan.

Background: In Japan, the mental health system has been shifting from hospitalization-based to community-based care; some organizations have gradually begun providing intensive case management (ICM) services. We developed an Intensive Case Management Screening Sheet (ICMSS) to screen for the need for ICM in people with mental illness.

Methods: The aim of this study was to examine the psychometric properties and discriminative ability of ICMSS. Read More

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http://dx.doi.org/10.1186/s13033-019-0278-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449981PMC
April 2019
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Real-life assessment of aripiprazole monthly (Abilify Maintena) in schizophrenia: a Canadian naturalistic non-interventional prospective cohort study.

BMC Psychiatry 2019 Apr 16;19(1):114. Epub 2019 Apr 16.

Douglas Mental Health University Institute, Montreal, Quebec, Canada.

Background: With previously established efficacy of aripiprazole once-monthly injectable formulation (AOM) in pre-registration randomized controlled trials, the current study was designed to evaluate its effectiveness in patients treated for schizophrenia in regular clinical settings in Canada.

Methods: Following their clinicians' decision to prescribe AOM, 193 patients with a diagnosis of schizophrenia, were recruited from 17 Canadian community or hospital-based settings. The primary outcome of global functioning was assessed with the Global Assessment of Functioning Scale (GAF) at 3-month intervals for 1 year. Read More

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http://dx.doi.org/10.1186/s12888-019-2103-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469112PMC
April 2019
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Comparing executive functioning and clinical and sociodemographic characteristics of people with schizophrenia who hold a driver's license to those who do not.

Can J Occup Ther 2019 Feb;86(1):70-80

Background.: Community engagement requires driving. However, there is paucity of research focusing on the potential to drive for people with schizophrenia. Read More

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http://dx.doi.org/10.1177/0008417419831399DOI Listing
February 2019
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Default mode network connectivity is associated with long-term clinical outcome in patients with schizophrenia.

Neuroimage Clin 2019 Apr 1;22:101805. Epub 2019 Apr 1.

Department of Mental Health Research, National Center for Mental Health, Seoul, Republic of Korea. Electronic address:

This study investigated whether resting-state functional connectivity is associated with long-term clinical outcomes of patients with schizophrenia. Resting-state brain images were obtained from 79 outpatients with schizophrenia and 30 healthy controls (HC), using a 3 T-MRI scanner. All patients were 20-50 years old with >3 years' duration of illness and appeared clinically stable. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451190PMC
April 2019
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Yoga as part of a package of care versus non-standard care for schizophrenia.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012807. Epub 2019 Apr 16.

Discipline of Physiotherapy, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

Background: Yoga is an ancient body-mind practice which originated in India and is popular in the Western world as a form of relaxation and exercise. It has been of interest for people with schizophrenia to determine the efficacy of yoga delivered as a package of care versus non-standard care.

Objectives: To examine the effects of yoga as part of a package of care versus non-standard care for schizophrenia. Read More

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http://dx.doi.org/10.1002/14651858.CD012807.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466669PMC
April 2019
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The validity, reliability and clinical utility of a performance-based executive function assessment in people with mild to moderate dementia.

Aging Ment Health 2019 Apr 16:1-9. Epub 2019 Apr 16.

f Occupational Therapy Department , TWGHs Jockey Club Rehabilitation Complex , Aberdeen , Hong Kong.

Objective: Performance-based evaluation of executive function by using real-world daily living activities is an important area of study. This approach has been used extensively in evaluating patients after stroke or traumatic brain injury and patients with schizophrenia. Most important is the fact that until now, there has been no validated performance-based evaluation of executive function in people with dementia. Read More

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http://dx.doi.org/10.1080/13607863.2019.1599818DOI Listing
April 2019
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Immunoneuropsychiatry - novel perspectives on brain disorders.

Nat Rev Neurol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune responses that involve both innate and adaptive immunity. Autoimmunity, chronic inflammation, infection and psychosocial stress can tip the scales towards disruption of higher-order networks. Read More

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http://www.nature.com/articles/s41582-019-0174-4
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http://dx.doi.org/10.1038/s41582-019-0174-4DOI Listing
April 2019
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Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.

Sci Rep 2019 Apr 15;9(1):6062. Epub 2019 Apr 15.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. Read More

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http://dx.doi.org/10.1038/s41598-019-42532-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465353PMC
April 2019
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Functional connectomics of affective and psychotic pathology.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478;

Converging evidence indicates that groups of patients with nominally distinct psychiatric diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In healthy populations, individual differences in behavior are reflected in variability across the collective set of functional brain connections (functional connectome). These data suggest that the spectra of transdiagnostic symptom profiles observed in psychiatric patients may map onto detectable patterns of network function. Read More

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http://dx.doi.org/10.1073/pnas.1820780116DOI Listing
April 2019
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Validation of the Brief Negative Symptom Scale and its association with functioning.

Schizophr Res 2019 Apr 13. Epub 2019 Apr 13.

Research Division, Institute of Mental Health, Singapore; North Region & Department of Psychosis, Institute of Mental Health, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:

Introduction: The Brief Negative Symptom Scale (BNSS) includes five domains of negative symptoms suggested by the NIMH Consensus Development Conference (anhedonia, asociality, avolition, blunted affect, and alogia), which could be clustered into two factors - Motivation-Pleasure (MAP) and Emotional Expressivity (EE). Our study aims to examine the psychometric properties of BNSS, and its association with functioning.

Methods: 274 individuals with schizophrenia were assessed on the BNSS, Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Global Assessment of Functioning Scale (GAF), Calgary Depression Scale for Schizophrenia (CDSS), and Simpson-Angus Extrapyramidal Side Effects Scale (SAS). Read More

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http://dx.doi.org/10.1016/j.schres.2019.04.005DOI Listing
April 2019
1 Read