40,197 results match your criteria Clinical Schizophrenia & Related Psychoses [Journal]


Real-world effectiveness of antipsychotic monotherapy and polytherapy in 1543 patients with acute-phase schizophrenia.

Asian J Psychiatr 2019 Feb 8;40:82-87. Epub 2019 Feb 8.

Department of Psychiatry, Numazu Chuo Hospital, Numazu, Japan.

Purpose: The effectiveness of antipsychotic treatments in the acute phase of schizophrenia in actual clinical practice remains somewhat unclear. Therefore, the purpose of the present naturalistic, multi-center study conducted from 1 year starting in September 2017 was to examine the response rate to an initial or second antipsychotic in newly admitted patients with acute-phase schizophrenia, as well as the response rate and quality of augmentation with two antipsychotics in patients who failed to respond to both the initial and second antipsychotics.

Results: In total, there were 660 (42. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.005DOI Listing
February 2019

Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No.388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China; Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang, People's Republic of China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, People's Republic of China. Electronic address:

Schizophrenia treatment remains a major challenge, especially the associated cognitive impairments, as these are not consistently alleviated by conventional antipsychotics. Recent animal and clinical studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) reduces the psychiatric symptoms and cognitive deficits of schizophrenia.The present study was designed to investigate the efficacy of SNP against schizophrenia-like behavioral and cognitive deficits in the dizocilpine (MK-801) rat model. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.008DOI Listing
February 2019

The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: decreased glial activation.

Behav Brain Res 2019 Feb 14. Epub 2019 Feb 14.

Beijing Tiantan Hospital, Capital Medical University, Advanced Innovation Center for Human Brain Protection, Capital Medical University, China National Clinical Research Center for Neurological Diseases, No. 119 South 4th Ring Road West, Fengtai District, Beijing, 100070, PR China. Electronic address:

Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms. Behavioural abnormalities associated with feeding mice a 0. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.026DOI Listing
February 2019

Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 610054, China; School of Life Science and Technology, Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address:

Schizophrenia (SCZ) is a severe neuropsychiatric disease associated with dysfunction of brain regions and networks. Recent, functional magnetic resonance imaging (fMRI) studies have determined that the global signal (GS) is an important source of the local neuronal activity. However, the dynamics of this effect in SCZ remains unknown. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.035DOI Listing
February 2019

Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Discipline of Medical Genetics, Department of Microscopic Morphology, Victor Babeş University of Medicine and Pharmacy Timișoara, Timișoara, Romania.

Background: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers. Read More

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http://dx.doi.org/10.1007/s11845-019-01985-xDOI Listing
February 2019

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.

Eur Neuropsychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st., Barcelona, Catalunya, Spain. Electronic address:

Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression). Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.003DOI Listing
February 2019

Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms.

J Am Acad Child Adolesc Psychiatry 2019 Jan 17. Epub 2019 Jan 17.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Center for Neurobehavioral Genetics, University of California, Los Angeles; University of California, Los Angeles.

Objective: Adults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development.

Method: We analyzed the cross-sectional data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC). Structural magnetic resonance neuroimaging data (sMRI) were collected on a subset of the PNC (N=989, ages 9-22 years old). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193004
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http://dx.doi.org/10.1016/j.jaac.2018.11.012DOI Listing
January 2019
2 Reads

Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank.

Br J Psychiatry 2019 Feb 15:1-8. Epub 2019 Feb 15.

Professor, Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics,Cardiff University,UK.

Background: Rare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including schizophrenia, autism spectrum disorder and intellectual disability. However, the effects of many individual CNVs in carriers without neurodevelopmental disorders are not yet fully understood, and little is known about the effects of reciprocal copy number changes of known pathogenic loci.AimsWe aimed to analyse the effect of CNV carrier status on cognitive performance and measures of occupational and social outcomes in unaffected individuals from the UK Biobank. Read More

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http://dx.doi.org/10.1192/bjp.2018.301DOI Listing
February 2019

Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective.

Pharmacogenomics 2019 Feb 15. Epub 2019 Feb 15.

MRC Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.

Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia. We now know that the genetic etiology of clozapine-associated neutropenia is complex and is likely to involve variants from several genes including HLA-DQB1, HLA-B and SLCO1B3/SLCO1B7. Read More

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http://dx.doi.org/10.2217/pgs-2018-0188DOI Listing
February 2019

Antenatal caregiving representations among expectant mothers with severe mental illness: a cross-sectional study.

J Reprod Infant Psychol 2019 Feb 15:1-14. Epub 2019 Feb 15.

a Department of Psychology , University of Copenhagen , Copenhagen , Denmark.

Objective: The study explores predictors of antenatal caregiving representations among mothers with a history of severe mental illness (SMI).

Background: Attachment research has demonstrated that multifactorial assessment of antenatal caregiving representations predicts later maternal behaviour and child attachment. However, the field lacks research among clinical groups. Read More

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http://dx.doi.org/10.1080/02646838.2019.1578868DOI Listing
February 2019

Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics.

Front Psychiatry 2018 31;9:753. Epub 2019 Jan 31.

Psychiatric Division, Haukeland University Hospital, Bergen, Norway.

Schizophrenia is considered a syndrome comprised by several disease phenotypes, covering a range of underlying pathologies. One of these disease mechanisms seems to involve immune dysregulation and neuroinflammation. While the current dopamine receptor-blocking antipsychotic drugs decrease psychotic symptoms and prevent relapse in the majority of patients with schizophrenia, there is a huge need to explore new treatment options that target other pathophysiological pathways. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365449PMC
January 2019

Collaborative Tele-Neuropsychiatry Consultation Services for Patients in Central Prisons.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):101-105

Department of Psychiatry, Tele Medicine Centre, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India.

Background: Tele-medicine helps to provide clinical care comparable to in-person treatment in various clinical settings. It is a novel system of healthcare delivery in both low-resource settings and sites where adequate medical care continues to pose greatest challenge like in prison's in India and worldwide.

Aim: To study the sociodemographic and clinical profile of patients from Central Prisons, having received collaborative Tele-Neuropsychiatric Care. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_215_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337995PMC
February 2019

Integration of imaging (epi)genomics data for the study of schizophrenia using group sparse joint nonnegative matrix factorization.

IEEE/ACM Trans Comput Biol Bioinform 2019 Feb 14. Epub 2019 Feb 14.

Schizophrenia (SZ) is a complex disease. Single nucleotide polymorphism (SNP), brain activity measured by functional magnetic resonance imaging (fMRI) and DNA methylation are all important biomarkers that can be used for the study of SZ. To our knowledge, there has been little effort to combine these three datasets together. Read More

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http://dx.doi.org/10.1109/TCBB.2019.2899568DOI Listing
February 2019

Gender and obstetric factors in the determination of the age of onset of schizophrenia in a Nigerian cohort.

J Abnorm Psychol 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Services, Federal Neuro-Psychiatric Hospital.

The importance of gender and obstetric factors as predictors of the age of onset of schizophrenia is debatable. Unfortunately, there is a significant dearth of studies in developing countries such as Nigeria. This study involved a survey of patients with schizophrenia (n = 1,445; N = 2,393), from March 2014 to March 2016, from a psychiatric hospital in southwest Nigeria. Read More

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http://dx.doi.org/10.1037/abn0000386DOI Listing
February 2019

Exploring the racial diagnostic bias of schizophrenia using behavioral and clinical-based measures.

J Abnorm Psychol 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychology.

There is evidence that African Americans are 2.4 times more likely to be diagnosed with a schizophrenia-spectrum diagnosis compared with White individuals, who are more likely to receive an affective diagnosis. The reason for these diagnostic discrepancies is unclear, however, 2 explanations have garnered attention: epigenetic differences and systematic error or bias in the diagnostic process. Read More

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http://dx.doi.org/10.1037/abn0000409DOI Listing
February 2019

The validation of a new online cognitive assessment tool: The MyCognition Quotient.

Int J Methods Psychiatr Res 2019 Feb 13:e1775. Epub 2019 Feb 13.

Department of Psychiatry, Amsterdam University Medical Centers (location AMC), Amsterdam, The Netherlands.

Objectives: Cognitive impairment affects many psychiatric patients, influences daily functioning, and should be an important treatment focus. Assessment of cognitive status is crucial in cognitive remediation studies. However, current test batteries have limitations. Read More

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http://dx.doi.org/10.1002/mpr.1775DOI Listing
February 2019
3.759 Impact Factor

Two-Year Clinical and Functional Outcomes of an Asian Cohort at Ultra-High Risk of Psychosis.

Front Psychiatry 2018 25;9:758. Epub 2019 Jan 25.

Institute of Mental Health, Singapore, Singapore.

To determine the 2-year clinical and functional outcomes of an Asian cohort at ultra-high risk (UHR) of psychosis. This was a longitudinal study with a follow-up period of 2 years on 255 help-seeking adolescents and young adults at UHR of psychosis managed by a multi-disciplinary mental health team in Singapore. Clients received case management, psychosocial, and pharmacological treatment as appropriate. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362403PMC
January 2019

The Group of Treatment Resistant Schizophrenias. Heterogeneity in Treatment Resistant Schizophrenia (TRS).

Authors:
Bruce J Kinon

Front Psychiatry 2018 30;9:757. Epub 2019 Jan 30.

Lundbeck North America, Deerfield, IL, United States.

Schizophrenia is composed of a heterogeneous group of patient segments. Our current notion of the heterogeneity in schizophrenia is based on patients presenting with diverse disease symptom phenotypes, risk factors, structural and functional neuropathology, and a mixed range of expressed response to treatment. It is important for clinicians to recognize the various clinical presentations of resistance to treatment in schizophrenia and to understand how heterogeneity across treatment resistant patient segments may potentially inform new strategies for the development of effective treatments for Treatment Resistant Schizophrenia (TRS). Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363683PMC
January 2019

Treating the "E" in "G × E": Trauma-Informed Approaches and Psychological Therapy Interventions in Psychosis.

Front Psychiatry 2019 30;10. Epub 2019 Jan 30.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

Despite advances in genetic research, causal variants affecting risk for schizophrenia remain poorly characterized, and the top 108 loci identified through genome-wide association studies (GWAS) explain only 3.4% of variance in risk profiles. Such work is defining the highly complex nature of this condition, with omnigenic models of schizophrenia suggesting that gene regulatory networks are sufficiently interconnected such that altered expression of any "peripheral" gene in a relevant cell type has the capacity to indirectly modulate the expression of "core" schizophrenia-associated genes. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363686PMC
January 2019

Enhanced Auditory Steady-State Response Using an Optimized Chirp Stimulus-Evoked Paradigm.

Sensors (Basel) 2019 Feb 12;19(3). Epub 2019 Feb 12.

Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.

: It has been reported recently that gamma measures of the electroencephalogram (EEG) might provide information about the candidate biomarker of mental diseases like schizophrenia, Alzheimer's disease, affective disorder and so on, but as we know it is a difficult issue to induce visual and tactile evoked responses at high frequencies. Although a high-frequency response evoked by auditory senses is achievable, the quality of the recording response is not ideal, such as relatively low signal-to-noise ratio (SNR). Recently, auditory steady-state responses (ASSRs) play an essential role in the field of basic auditory studies and clinical uses. Read More

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http://www.mdpi.com/1424-8220/19/3/748
Publisher Site
http://dx.doi.org/10.3390/s19030748DOI Listing
February 2019
4 Reads

The Origins of Human Functional Stereotaxis: A Reappraisal.

Stereotact Funct Neurosurg 2019 Feb 13:1-6. Epub 2019 Feb 13.

Department of Neurosurgery, Medical School Hannover, Hannover, Germany.

In order to shed light on the first application of human functional stereotactic neurosurgery, whether it was in the realm of movement disorders, as has been claimed repeatedly, or in the realm of psychiatry, a review of the original scholarly literature was conducted. Tracking and scrutinising original publications by Spiegel and Wycis, the pioneers of human stereotactic neurosurgery, it was found that its origin and the very incentive for its development and first clinical use were to avoid the side effects of frontal leucotomy. The first applications of functional stereotactic neurosurgery were in performing dorsomedial thalamotomies in psychiatric patients; it was only later that the stereotactic technique was applied in patients with chronic pain, movement disorders and epilepsy. Read More

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http://dx.doi.org/10.1159/000496157DOI Listing
February 2019

Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder.

J Affect Disord 2019 Feb 6;249:63-72. Epub 2019 Feb 6.

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Psychiatry, Länsi-Pohja Healthcare District; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District; Mental Health Services and Basic Health Care District of Kallio; and Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Finland.

Background: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders.

Methods: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.011DOI Listing
February 2019
1 Read

Retrospective Analysis of the Effectiveness and Tolerability of Long-Acting Paliperidone Palmitate Antipsychotic in Adolescent First-Episode Schizophrenia Patients.

J Child Adolesc Psychopharmacol 2019 Feb 13. Epub 2019 Feb 13.

1 Department of Child and Adolescent Psychiatry, Clinical Hospital Centre Rijeka, Rijeka, Croatia.

Objective: The aim of this study was to explore the effectiveness and tolerability of long-acting paliperidone palmitate antipsychotic in adolescent first-episode schizophrenia patients while comparing the results with the oral antipsychotic risperidone.

Methods: This study is a retrospective, noninterventional study to assess the effectiveness and tolerability of long-acting injectable antipsychotic paliperidone palmitate in first-episode adolescent patients during the first 12 months of treatment compared with the oral antipsychotic risperidone. The data include general sociodemographic characteristics, number of hospitalizations, side effects, and the following clinical scales: Positive and Negative Syndrome Scale (PANSS), Personal and Social Performance Scale (PSP), Clinical Global Impression Improvement and Severity (CGI-I and CGI-S), and Treatment Satisfaction Questionnaire for Medication (TSQM). Read More

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http://dx.doi.org/10.1089/cap.2018.0044DOI Listing
February 2019

[Breakthrough in understanding the molecular causes of psychiatric disorders].

Nervenarzt 2019 Feb;90(2):99-106

Institut für Humangenetik, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.

A long-established hypothesis is that genetic factors contribute to the development of psychiatric diseases, including common illnesses such as schizophrenia and the affective disorders; however, reliable molecular identification of these factors represents a far more recent innovation. This has been rendered possible by technological advances in the individual characterization of the human genome and the combining of large genetic datasets at the international level. For the first time, the results of genome-wide analyses provide researchers with systematic insights into disease-relevant biological mechanisms. Read More

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http://dx.doi.org/10.1007/s00115-018-0670-6DOI Listing
February 2019

Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.

Neuropsychopharmacology 2019 Feb 6. Epub 2019 Feb 6.

Psychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abnormal gamma-band oscillations (GBO) have been frequently associated with the pathophysiology of schizophrenia. GBO are modulated by glutamate, a neurotransmitter, which is continuously discussed to shape the complex symptom spectrum in schizophrenia. The current study examined the effects of ketamine, a glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist, on the auditory-evoked gamma-band response (aeGBR) and psychopathological outcomes in healthy volunteers to investigate neuronal mechanisms of psychotic behavior. Read More

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http://dx.doi.org/10.1038/s41386-019-0328-5DOI Listing
February 2019

Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling.

BMC Pharmacol Toxicol 2019 Feb 12;20(1):10. Epub 2019 Feb 12.

Department of Psychiatry, Hospital Affiliated to Guizhou Medical University, Guiyang, 550004, Guizhou, China.

Background: There is evidence that atypical antipsychotics (APs) increase risk of osteoporosis in schizophrenia patients, however the mechanism is unclear. The aim of the study was to explore the molecular mechanisms about Wnt/β-catenin signal pathway underlying the osteal side effects of APs.

Methods: We cultured human osteoblast cell line hFob1. Read More

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http://dx.doi.org/10.1186/s40360-019-0287-9DOI Listing
February 2019

Sociodemographic, environmental characteristics and comorbidities of older adults with schizophrenia who access community health service support: A national cross-sectional study.

Aust N Z J Psychiatry 2019 Feb 13:4867419828480. Epub 2019 Feb 13.

5 Specialist Mental Health Services, Canterbury District Health Board, Christchurch, New Zealand.

Objectives:: Schizophrenia is a serious and chronic mental illness known to have broad ranging impacts for individuals across the lifespan, yet research on the disease in older adults is sparse. This study provides a profile of the sociodemographic, environmental and diagnostic characteristics of older community residents with schizophrenia using a national database.

Methods:: A cross-sectional sample of individuals who underwent community needs assessment using the standardised Home Care International Residential Assessment Instrument between 1 September 2012 and 31 January 2016 was utilised. Read More

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http://dx.doi.org/10.1177/0004867419828480DOI Listing
February 2019

[Schizophrenia: What Non-Psychiatrist Physicians Need to Know].

Acta Med Port 2019 Feb 1;32(1):70-77. Epub 2019 Feb 1.

Serviço de Psiquiatria. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Departamento de Psiquiatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Schizophrenia is a disabling and severe mental illness that affects all social classes and racial and ethnic groups, spreading across every part of the world. It's more frequent in males and it usually manifests itself in late adolescence or early adulthood and its early detection by all clinicians is important so that there is a proper referral to specialized psychiatric care. This article intends to update the knowledge regarding the diagnosis, treatment and prognosis of schizophrenia, with an emphasis on the warning signs for a timely referral to psychiatric evaluation. Read More

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http://dx.doi.org/10.20344/amp.10768DOI Listing
February 2019
1 Read

Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300.

Schizophr Bull 2018 Dec 8. Epub 2018 Dec 8.

Mental Health Service, San Francisco Veterans Affairs Health Care System, San Francisco, CA.

Identification of neurophysiological abnormalities associated with schizophrenia that predate and predict psychosis onset may improve clinical prediction in the psychosis risk syndrome (PRS) and help elucidate the pathogenesis of schizophrenia. Amplitude reduction of the P300 event-related potential component reflects attention-mediated processing deficits and is among the most replicated biological findings in schizophrenia, making it a candidate biomarker of psychosis risk. The relative extent to which deficits in P300 amplitudes elicited by auditory and visual oddball stimuli precede psychosis onset during the PRS and predict transition to psychosis, however, remains unclear. Read More

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http://dx.doi.org/10.1093/schbul/sby167DOI Listing
December 2018
1 Read

Cannabis Dependence or Abuse in Kidney Transplantation: Implications for Posttransplant Outcomes.

Transplantation 2019 Feb 4. Epub 2019 Feb 4.

Division of Nephrology, Saint Louis University School of Medicine, St. Louis, MO, USA.

Background: Cannabis is categorized as an illicit drug in most US states, but legalization for medical indications is increasing. Policies and guidance regarding cannabis use in transplant patients remain controversial.

Methods: We examined a database linking national kidney transplant records (n=52,689) with Medicare claims to identify diagnoses of cannabis dependence or abuse (CDOA) and associations (adjusted hazard ratio, 95% LCL aHR95% UCL) with graft, patient and other clinical outcomes. Read More

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http://dx.doi.org/10.1097/TP.0000000000002599DOI Listing
February 2019
1 Read

Postinjection Delirium/Sedation Syndrome After 31st Long-Acting Olanzapine Depot Injection.

Clin Neuropharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India.

Objective: Long-acting depot preparations of antipsychotics are the mainstay of treatment for patients with schizophrenia who show nonadherence to their medications. Olanzapine pamoate is one of the recently approved long-acting depot psychotropic preparations that have shown its efficacy both in clinical trials and in clinical uses against the illness. However, emerging literature indicates toward a cluster of adverse effects known as postinjection delirium/sedation syndrome (PDSS). Read More

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http://dx.doi.org/10.1097/WNF.0000000000000329DOI Listing
February 2019
2 Reads
1.836 Impact Factor

The Role of Biomarkers in Psychiatry.

Adv Exp Med Biol 2019 ;1118:135-162

Neurodegenerative Disease Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.

Psychiatric illnesses are cognitive and behavioral disorders of the brain. At present, psychiatric diagnosis is based on DSM-5 criteria. Even if endophenotype specificity for psychiatric disorders is discussed, it is difficult to study and identify psychiatric biomarkers to support diagnosis, prognosis, or clinical response to treatment. Read More

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http://dx.doi.org/10.1007/978-3-030-05542-4_7DOI Listing
January 2019
1 Read

Fully-integrated medical home for people with severe and persistent mental illness: A description and outcome analysis of a Medicare Advantage Chronic Special Needs Program.

Authors:
Robert Myers

Ment Illn 2018 Nov 5;10(2):7819. Epub 2018 Dec 5.

Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.

People with severe persistent mental illness pose a significant challenge to managed care organizations and society in general. The financial costs are staggering as is the community impact including homelessness and incarceration. This population also has a high incident of chronic comorbid disorders that not only drives up healthcare costs but also significantly shortens longevity. Read More

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http://dx.doi.org/10.4081/mi.2018.7819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342024PMC
November 2018
2 Reads

Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.

Ment Illn 2018 Nov 20;10(2):7812. Epub 2018 Dec 20.

CTA Villa Chiara Psychiatric Rehabilitation and Research, University of Catania, Italy.

Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of exercises (SRT+CRT), whereas an equal control group was treated with sets of exercises (SRT+PBO) belonging to the Cogpack® software. Read More

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http://dx.doi.org/10.4081/mi.2018.7812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342025PMC
November 2018
2 Reads

Bone Status in Obese, Non-diabetic, Antipsychotic-Treated Patients, and Effects of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide on Bone Turnover Markers and Bone Mineral Density.

Front Psychiatry 2018 28;9:781. Epub 2019 Jan 28.

Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark.

Low bone mineral density (BMD) may constitute an underestimated comorbidity in schizophrenia patients undergoing long-term antipsychotic treatment. Glucagon-like peptide 1 (GLP-1) receptor agonists are antidiabetic drugs, which may also affect bone turnover. In planned secondary analyses of a 3 months, double-blind, randomized, placebo-controlled trial ( = 45), we explored effects of the GLP-1 receptor agonist exenatide 2 mg once-weekly ( = 23), or placebo ( = 22) on bone turnover markers (BTMs) and BMD in chronic, obese, antipsychotic-treated patients with schizophrenia spectrum disorder. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360839PMC
January 2019
1 Read

Clinical Practice Guidelines for the Management of Schizophrenia in Children and Adolescents.

Indian J Psychiatry 2019 Jan;61(Suppl 2):277-293

Department of Psychiatry, PGIMER, Chandigarh, India.

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_556_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345123PMC
January 2019
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Leukocytoclastic vasculitis secondary to clozapine.

Indian J Psychiatry 2019 Jan-Feb;61(1):94-96

Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.

Leukocytoclastic vasculitis (LCV) may be secondary to drugs, underlying infection, collagen vascular disorders, or malignancy. Drug-induced vasculitis contributes to 10% of vasculitic skin lesions cases usually developing within 7-21 days of treatment initiation. The present case highlights a report of LCV in a 59-year-old male with a history of paranoid schizophrenia on clozapine therapy. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_384_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341920PMC
February 2019
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Are emotion recognition deficits in patients with schizophrenia states or traits? A 6-month follow-up study.

Indian J Psychiatry 2019 Jan-Feb;61(1):45-52

Department of Psychiatry, Erenkoy Mental Health and Neurological Disease Trainig and Research Hospital, Istanbul, Turkey.

Background: Patients with schizophrenia were found to be less successful at emotion recognition tasks (ERTs) than healthy individuals. There is a debate surrounding whether this deficit is permanent or temporary. The current study aims to assess how emotion recognition skills are affected by treatment processes and during the course of the disease and also to determine the relation of this change with clinical assessment scales, other cognitive functions, and quantitative electroencephalography (QEEG). Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_307_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341926PMC
February 2019
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Switching patients with schizophrenia from paliperidone palmitate to aripiprazole lauroxil: A 6-month, prospective, open-label study.

Schizophr Res 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92697, United States. Electronic address:

We assessed the effectiveness of switching from paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) to aripiprazole lauroxil (AL). Prospective, 6-month study in patients with schizophrenia with residual symptoms or intolerance with PP/RLAI. Effectiveness assessed via all-cause and medication-related discontinuation; CGI-S/BPRS and adverse event monitoring assessed efficacy/tolerability, respectively. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.038DOI Listing
February 2019
7 Reads

The Intersection of Sleep Apnea and Severe Mental Illness in Veterans.

Psychosomatics 2019 Jan 22. Epub 2019 Jan 22.

VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA; Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA. Electronic address:

Background: Individuals with serious mental illness (SMI) have a high prevalence of risk factors for sleep apnea, but these risk factors often go unrecognized, partly due to the overlap among sleep apnea, somatic conditions, and symptoms (e.g., obesity, daytime sleepiness), leading to potential under-recognition of sleep apnea in a high-risk population. Read More

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http://dx.doi.org/10.1016/j.psym.2019.01.007DOI Listing
January 2019
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Machine learning in mental health: a scoping review of methods and applications.

Psychol Med 2019 Feb 12:1-23. Epub 2019 Feb 12.

Deakin University, Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health,Geelong,Australia.

Background: This paper aims to synthesise the literature on machine learning (ML) and big data applications for mental health, highlighting current research and applications in practice.

Methods: We employed a scoping review methodology to rapidly map the field of ML in mental health. Eight health and information technology research databases were searched for papers covering this domain. Read More

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http://dx.doi.org/10.1017/S0033291719000151DOI Listing
February 2019

Illness management and recovery: one-year follow-up of a randomized controlled trial in Danish community mental health centers: long-term effects on clinical and personal recovery.

BMC Psychiatry 2019 Feb 11;19(1):65. Epub 2019 Feb 11.

Copenhagen Research Center for Mental Health - CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Illness Management and Recovery (IMR) is a curriculum-based rehabilitation program for people with severe mental illness with the short-term aim of improving illness self-management and the long-term aim of helping people achieve clinical and personal recovery.

Method: Participants with schizophrenia or bipolar disorders were recruited from three community mental health centers in the Capital Region of Denmark and randomized to receive group-based IMR and treatment as usual or only the usual intervention. All outcomes were assessed at baseline, postintervention, and the one-year follow-up. Read More

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http://dx.doi.org/10.1186/s12888-019-2048-0DOI Listing
February 2019
2 Reads

Sensory-targeted cognitive training for schizophrenia.

Expert Rev Neurother 2019 Feb 9. Epub 2019 Feb 9.

a INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team , Lyon , F-69000 , France.

Introduction: Auditory and visual sensory dysfunctions are key pathophysiological features of schizophrenia (Sz). Therefore, remedial interventions that directly target such impairments could potentially drive gains in higher-order cognition (e.g. Read More

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http://dx.doi.org/10.1080/14737175.2019.1581609DOI Listing
February 2019
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Applying economic models to estimate local economic benefits of improved coverage of early intervention for psychosis.

Early Interv Psychiatry 2019 Feb 10. Epub 2019 Feb 10.

Division of Psychology and Mental Health, University of Manchester, Manchester, UK.

Aim: Early Intervention Psychosis Services (EIPS) for people experiencing First Episode Psychosis (FEP) offer important clinical and non-clinical benefits over standard care. Similarly, intervention for Clinical High Risk for Psychosis state (CHR-P) can prevent psychosis, ameliorate symptoms and have non-clinical benefits. This study aimed to estimate associated local economic benefits of FEP and CHR-P services compared with standard care. Read More

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http://dx.doi.org/10.1111/eip.12787DOI Listing
February 2019
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Emotion regulation across the psychosis continuum.

Dev Psychopathol 2019 Feb 11:1-9. Epub 2019 Feb 11.

Department of Psychology,University of Georgia,Athens, GA,USA.

Emotion regulation dysfunction is characteristic of psychotic disorders, but little is known about how the use of specific types of emotion regulation strategies differs across phases of psychotic illness. This information is vital for understanding factors contributing to psychosis vulnerability states and developing targeted treatments. Three studies were conducted to examine emotion regulation across phases of psychosis, which included (a) adolescent community members with psychotic-like experiences (PLEs; n = 262) and adolescents without PLEs (n = 1,226); (b) adolescents who met clinical high-risk criteria for a prodromal syndrome (n = 29) and healthy controls (n = 29); and (c) outpatients diagnosed with schizophrenia or schizoaffective disorder (SZ; n = 61) and healthy controls (n = 67). Read More

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http://dx.doi.org/10.1017/S0954579418001682DOI Listing
February 2019
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A new hope for early psychosis care: the evolving landscape of digital care tools.

Br J Psychiatry 2019 Feb 11:1-4. Epub 2019 Feb 11.

Assistant Professor in Psychiatry,Department of Psychiatry,University of California; andDirector of Clinical Training,UC Davis Imaging Research Center,USA.

SummaryImproving understanding of and outcomes for early-course psychosis (ECP) is a recognised global mental health priority. We argue digital health technologies can advance care for ECP by better accounting for clinical heterogeneity, offering better predictive models, increasing access to early interventions and enhancing existing treatment options.Declaration of interestL. Read More

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http://dx.doi.org/10.1192/bjp.2019.8DOI Listing
February 2019
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The interhemispheric miscommunication theory of auditory verbal hallucinations in schizophrenia.

Int J Psychophysiol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Psychiatry and Psychotherapy, Justus-Liebig-University, Giessen, Germany.

Auditory verbal hallucinations (AVH) are hallmark symptoms of schizophrenia and have been linked to abnormal activation, connectivity and integration within the auditory, language, and memory brain networks. The interhemispheric miscommunication theory of AVH is based on a steadily growing number of studies using a variety of modalities (EEG, fMRI, DTI) reporting that both altered integrity of the interhemispheric auditory pathways (Gavrilescu et al. 2010; Hubl et al. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.02.002DOI Listing
February 2019
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