25 results match your criteria Clinical Reviews in Bone and Mineral Metabolism[Journal]

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Clinical measurements of bone tissue mechanical behavior using reference point indentation.

Clin Rev Bone Miner Metab 2018 Sep 12;16(3):87-94. Epub 2018 Sep 12.

Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO.

Over the last thirty years, it has become increasingly clear the amount of bone (e.g. 'bone quantity') and the quality of the bone matrix (e. Read More

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http://dx.doi.org/10.1007/s12018-018-9249-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457660PMC
September 2018

Tendon healing in the context of complex fractures.

Clin Rev Bone Miner Metab 2018 Dec 29;16(4):131-141. Epub 2018 Dec 29.

Department of Biomedical Engineering, University of Delaware, Newark, Delaware 19716.

Tendons connect muscle to bone and play an integral role in bone and joint alignment and loading. Tendons act as pulleys that provide anchorage of muscle forces for joint motion and stability, as well as for fracture reduction and realignment. Patients that experience complex fractures also have concomitant soft tissue injuries, such as tendon damage or rupture. Read More

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http://dx.doi.org/10.1007/s12018-018-9254-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386191PMC
December 2018

GLUCOCORTICOID EXCESS IN BONE AND MUSCLE.

Clin Rev Bone Miner Metab 2018 Mar 5;16(1):33-47. Epub 2018 Feb 5.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, 46202.

Glucocorticoids (GC), produced and released by the adrenal glands, regulate numerous physiological processes in a wide range of tissues. Because of their profound immunosuppressive and anti-inflammatory actions, GC are extensively used for the treatment of immune and inflammatory conditions, the management of organ transplantation, and as a component of chemotherapy regimens for cancers. However, both pathologic endogenous elevation and long-term use of exogenous GC are associated with severe adverse effects. Read More

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http://link.springer.com/10.1007/s12018-018-9242-3
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http://dx.doi.org/10.1007/s12018-018-9242-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022857PMC
March 2018
34 Reads

Bone Fracture Acute Phase Response-A Unifying Theory of Fracture Repair: Clinical and Scientific Implications.

Clin Rev Bone Miner Metab 2018 29;16(4):142-158. Epub 2018 Dec 29.

2Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN 37232 USA.

Bone fractures create five problems that must be resolved: bleeding, risk of infection, hypoxia, disproportionate strain, and inability to bear weight. There have been enormous advancements in our understanding of the molecular mechanisms that resolve these problems after fractures, and in best clinical practices of repairing fractures. We put forth a modern, comprehensive model of fracture repair that synthesizes the literature on the biology and biomechanics of fracture repair to address the primary problems of fractures. Read More

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http://dx.doi.org/10.1007/s12018-018-9256-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404386PMC
December 2018

A Review on Bone Mineral Density Loss in Total Knee Replacements Leading to Increased Fracture Risk.

Clin Rev Bone Miner Metab 2017 27;15(4):162-174. Epub 2017 Oct 27.

University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU UK.

The link between low bone mineral density (BMD) scores leading to greater fracture risk is well established in the literature; what is not fully understood is the impact of total knee replacements/revisions or arthroplasties on BMD levels. This literature review attempts to answer this question. Several different databases using specific key terms were searched, with additional papers retrieved via bibliographic review. Read More

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http://dx.doi.org/10.1007/s12018-017-9238-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698368PMC
October 2017
7 Reads

Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale.

Clin Rev Bone Miner Metab 2016 Sep 22;14(3):133-149. Epub 2016 Aug 22.

Department of Materials Science and Engineering, Cornell University, Ithaca, NY.

This review presents an overview of the characterization techniques available to experimentally evaluate bone quality, defined as the geometric and material factors that contribute to fracture resistance independently of areal bone mineral density (aBMD) assessed by dual energy x-ray absorptiometry. The methods available for characterization of the geometric, compositional, and mechanical properties of bone across multiple length scales are summarized, along with their outcomes and their advantages and disadvantages. Examples of how each technique is used are discussed, as well as practical concerns such as sample preparation and whether or not each testing method is destructive. Read More

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http://dx.doi.org/10.1007/s12018-016-9222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604329PMC
September 2016
26 Reads

Clinical and Genetic Advances in Paget's Disease of Bone: a Review.

Clin Rev Bone Miner Metab 2017 19;15(1):37-48. Epub 2016 Dec 19.

Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain.

Paget's disease of bone (PDB) is the second most common metabolic bone disorder, after osteoporosis. It is characterised by focal areas of increased and disorganised bone turnover, coupled with increased bone formation. This disease usually appears in the late stages of life, being slightly more frequent in men than in women. Read More

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http://dx.doi.org/10.1007/s12018-016-9226-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309316PMC
December 2016
6 Reads

Synchrotron Imaging Assessment of Bone Quality.

Clin Rev Bone Miner Metab 2016;14(3):150-160. Epub 2016 Sep 7.

MSk Laboratory, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W6 8PR UK.

Bone is a complex hierarchical structure, and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure. The hierarchical levels are interrelated, especially the micro-architecture, collagen and mineral components; hence, analysis of their specific roles in bone strength and stiffness is difficult. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018259PMC
http://dx.doi.org/10.1007/s12018-016-9223-3DOI Listing
September 2016
12 Reads

Locomotive Syndrome: Operational Definition Based on a Questionnaire, and Exercise Interventions on Mobility Dysfunction in Elderly People.

Clin Rev Bone Miner Metab 2016;14:119-130. Epub 2016 Jun 3.

Nagano University of Health and Medicine, 11-1 Imaihara, Kawanakajima-chou, Nagano, 381-2227 Japan.

The increasing elderly population has a great impact on public health, and it is important to understand the progression of musculoskeletal disorders seen in this population. To establish useful preventative methods for such locomotive disorders, we must detect early changes in these individuals and identify those at risk in order to implement early interventions. The purpose of this review was: (1) to introduce an operational definition of locomotion dysfunction to prevent a care-need condition, and to verify its validity through a prospective cohort study, and (2) to review the indication of exercise intervention for multiple musculoskeletal involvements from the preceding literature. Read More

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http://dx.doi.org/10.1007/s12018-016-9210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906075PMC
June 2016
12 Reads

Epidemiology of Locomotive Organ Disorders and Symptoms: An Estimation Using the Population-Based Cohorts in Japan.

Clin Rev Bone Miner Metab 2016;14:68-73. Epub 2016 Jun 7.

National Rehabilitation Center for Persons with Disabilities, Saitama, 359-0042 Japan.

Although locomotive organ diseases such as osteoporotic fractures and osteoarthritis are major reasons for disability and require support, little information is available regarding the epidemiology of musculoskeletal dysfunction and its symptoms including knee pain and lumbar pain in Japan. The research on osteoarthritis/osteoporosis against disability (ROAD) study is a prospective cohort study that aims at elucidating the environmental and genetic background for locomotive organ diseases, and has been ongoing since 2005. In this review, epidemiological indices such as prevalence of locomotive organ diseases including knee osteoarthritis, lumbar spondylosis, and osteoporosis were clarified using baseline survey results of the ROAD study. Read More

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http://dx.doi.org/10.1007/s12018-016-9211-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906121PMC
June 2016
10 Reads

Locomotive Syndrome: Definition and Management.

Clin Rev Bone Miner Metab 2016;14:56-67. Epub 2016 May 25.

National Rehabilitation Center for Persons with Disabilities, 4-1, Namiki, Tokorozawa, Saitama Japan.

Locomotive syndrome is a condition of reduced mobility due to impairment of locomotive organs. Since upright bipedal walking involves minutely controlled movement patterns, impairment of any aspect of the locomotive organs has the potential to adversely affect it. In addition to trauma, chronic diseases of the locomotive organs, which progress with repeated bouts of acute exacerbations, are common causes of the locomotive syndrome. Read More

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http://dx.doi.org/10.1007/s12018-016-9208-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906066PMC
May 2016
71 Reads

Physiology of Mechanotransduction: How Do Muscle and Bone "Talk" to One Another?

Clin Rev Bone Miner Metab 2014 Jun;12(2):77-85

Muscle Biology Research Group-MUBIG, School of Nursing and Health Studies, University of Missouri-Kansas City (UMKC), 2464 Charlotte St, Kansas City, MO 64108, USA; School of Medicine, UMKC, Kansas City, MO, USA; School of Pharmacy, UMKC, Kansas City, MO, USA.

The complexity of cell interactions with their microenvironment and their ability to communicate at the autocrine, paracrine, and endocrine levels has gradually but significantly evolved in the last three decades. The musculoskeletal system has been historically recognized to be governed by a relationship of proximity and function, chiefly dictated by mechanical forces and the work of gravity itself. In this review article, we first provide a historical overview of the biomechanical theory of bone- muscle interactions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380142PMC
http://dx.doi.org/10.1007/s12018-013-9152-3DOI Listing
June 2014
19 Reads

Bone and Muscle Pleiotropy: The Genetics of Associated Traits.

Authors:
Robert D Blank

Clin Rev Bone Miner Metab 2014 Jun 18;12(2):61-65. Epub 2014 Feb 18.

Clement J. Zablocki VAMC, Milwaukee, WI, USA.

Bone and muscle mass are highly correlated. In part, this is a consequence of both tissues sharing common genetic determinants. In addition, both tissues are responsive to their mechanical environments. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724571PMC
June 2014
6 Reads

The role of vitamin D in the metabolic homeostasis of diabetic bone.

Clin Rev Bone Miner Metab 2013 Mar;11(1):28-37

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR.

Most studies across a variety of geographic locations suggest that vitamin D insufficiency is more common in individuals with type 1 diabetes (T1D) compared to the general population. In type 2 diabetes (T2D), while obesity is commonplace and lower vitamin D levels are present in obese adolescents and adults, the association between vitamin D insufficiency and T2D is less clear. Studies suggest that the relationship between T2D and vitamin D may be concurrently influenced by ethnicity, geography, BMI and age. Read More

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http://dx.doi.org/10.1007/s12018-012-9127-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632098PMC
March 2013
6 Reads

Safety of Anti-Diabetic Therapies on Bone.

Clin Rev Bone Miner Metab 2013 Mar 7;11(1):49-58. Epub 2012 Feb 7.

Department of Orthopaedic Surgery, Department of Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614.

Osteoporosis and diabetic disease have reached epidemic proportion and create significant public health concerns. The prevalence of these diseases is alarming, and indicates that in the US, 50% of elderly individuals are osteoporotic and almost 20% of population has either diabetic or prediabetic conditions (Centers for Disease Control and Prevention; http://www.cdc. Read More

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http://dx.doi.org/10.1007/s12018-012-9129-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608134PMC
March 2013
7 Reads

Osteocalcin and the Regulation of Glucose Metabolism.

Clin Rev Bone Miner Metab 2013 Mar;11(1):11-16

Uncarboxylated osteocalcin enhances insulin and adiponectin release and improves glucose tolerance in mice. Data in humans do not unequivocally support a role for osteocalcin in glucose homeostasis. Changes in the amount of uncarboxylated osteocalcin induced by vitamin K or warfarin treatment are not associated with changes in glucose and insulin concentrations. Read More

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http://dx.doi.org/10.1007/s12018-012-9126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476242PMC
March 2013
6 Reads

Approach to the Adult Kidney Stone Former.

Authors:
Naim Maalouf

Clin Rev Bone Miner Metab 2012 Mar;10(1):38-49

Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism, University of Texas Southwestern Medical Center Dallas, TX, U.S.A.

Nephrolithiasis is a prevalent and costly condition with high recurrence rate. A medical evaluation to identify abnormalities responsible for nephrolithiasis and guide subsequent therapy has been advocated to reduce the risk of stone recurrence. The evaluation of kidney stone formers generally comprises an extensive medical history to identify metabolic, environmental, dietary and/or genetic factors contributing to stone formation. Read More

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http://dx.doi.org/10.1007/s12018-011-9111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361075PMC
March 2012
7 Reads

Cysteine Protease Cathepsins in Atherosclerosis and Abdominal Aortic Aneurysm.

Clin Rev Bone Miner Metab 2011 Jun 18;9(2):138-147. Epub 2011 Jun 18.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Extracellular matrix remodeling is an important mechanism in the initiation and progression of cardiovascular diseases. Cysteine protease cathepsins are among the important proteases that affect major events in the pathogenesis of atherosclerosis and abdominal aortic aneurysm, including smooth muscle cell transmigration through elastic lamina, macrophage foam cell formation, vascular cell and macrophage apoptosis, and plaque rupture. These events have been studied in cathepsin deficiencies and cathepsin inhibitor deficiencies in mice and have provided invaluable insights regarding the roles of cathepsins in cardiovascular diseases. Read More

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http://dx.doi.org/10.1007/s12018-011-9098-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324310PMC
June 2011
9 Reads

Mechanisms of Stone Formation.

Clin Rev Bone Miner Metab 2011 Dec;9(3-4):187-197

Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 And The Department of Veterans Affairs, Medical Center, Milwaukee, WI 53295.

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http://link.springer.com/10.1007/s12018-011-9104-8
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http://dx.doi.org/10.1007/s12018-011-9104-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252394PMC
December 2011
15 Reads

Uric Acid Nephrolithiasis: A Systemic Metabolic Disorder.

Clin Rev Bone Miner Metab 2011 Dec;9(3-4):207-217

Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8885, USA, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Uric acid nephrolithiasis is characteristically a manifestation of a systemic metabolic disorder. It has a prevalence of about 10% among all stone formers, the third most common type of kidney stone in the industrialized world. Uric acid stones form primarily due to an unduly acid urine; less deciding factors are hyperuricosuria and a low urine volume. Read More

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http://dx.doi.org/10.1007/s12018-011-9106-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100778PMC
December 2011
7 Reads

The Load-Bearing Mechanosome Revisited.

Clin Rev Bone Miner Metab 2010 Nov;8(4):213-223

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

We introduced the mechanosome hypothesis in 2003 as a heuristic model for investigating mechanotransduction in bone (Pavalko et al., J Cell Biochem, 2003, 88(1):104-112). This model suggested specific approaches for investigating how mechanical information is conveyed from the membrane of the sensor bone cell to the target genes and how this transmitted information from the membrane is converted into changes in transcription. Read More

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http://dx.doi.org/10.1007/s12018-010-9075-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071518PMC
November 2010
10 Reads

Ionizing Radiation and Bone Loss: Space Exploration and Clinical Therapy Applications.

Clin Rev Bone Miner Metab 2011 Mar;9(1):54-62

Section of Molecular Medicine and Department of Radiation Oncology, Comprehensive Cancer Center, Wake Forest School of Medicine, Radiation Biology 405 NRC, Medical Center Blvd., Winston-Salem, NC 27157, USA

Damage to normal, nontumor bone tissue following therapeutic irradiation increases the risk of fracture among cancer patients. For example, women treated for various pelvic tumors have been shown to have a greater than 65% increased incidence of hip fracture by 5 years postradiotherapy. Another practical situation in which exposure to ionizing radiation may negatively impact skeletal integrity is during extended spaceflight missions. Read More

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http://dx.doi.org/10.1007/s12018-011-9092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401480PMC
March 2011
11 Reads

Gap Junctions and Biophysical Regulation of Bone Cells.

Clin Rev Bone Miner Metab 2010 Dec;8(4):189-200

Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

Communication between osteoblasts, osteoclasts, and osteocytes is integral to their ability to build and maintain the skeletal system and respond to physical signals. Various physiological mechanisms, including nerve communication, hormones, and cytokines, play an important role in this process. More recently, the important role of direct, cell-cell communication via gap junctions has been established. Read More

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http://dx.doi.org/10.1007/s12018-011-9084-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677790PMC
December 2010
9 Reads

Vitamin D Deficiency and Its Health Consequences in Africa.

Clin Rev Bone Miner Metab 2009 ;7:94-106

Human Nutrition Research, MRC, Cambridge, UK ; MRC Keneba, MRC, Keneba, The Gambia.

Africa is heterogeneous in latitude, geography, climate, food availability, religious and cultural practices, and skin pigmentation. It is expected, therefore, that prevalence of vitamin D deficiency varies widely, in line with influences on skin exposure to UVB sunshine. Furthermore, low calcium intakes and heavy burden of infectious disease common in many countries may increase vitamin D utilization and turnover. Read More

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http://dx.doi.org/10.1007/s12018-009-9038-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126271PMC
January 2009
14 Reads

Affective Disorders, Bone Metabolism, and Osteoporosis.

Authors:
Briana Mezuk

Clin Rev Bone Miner Metab 2008 Dec;6(3-4):101-113

Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory, 3644 SPH Tower, Ann Arbor, MI 48109, USA.

The nature of the relationship between affective disorders, bone mineral density (BMD), and bone metabolism is unresolved, although there is growing evidence that many medications used to treat affective disorders are associated with low BMD or alterations in neuroendocrine systems that influence bone turnover. The objective of this review is to describe the current evidence regarding the association of unipolar and bipolar depression with BMD and indicators of bone metabolism, and to explore potential mediating and confounding influences of those relationships. The majority of studies of unipolar depression and BMD indicate that depressive symptoms are associated with low BMD. Read More

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http://dx.doi.org/10.1007/s12018-009-9025-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716385PMC
December 2008
7 Reads
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