1,938 results match your criteria Clinical Research in Cardiology[Journal]


Predictive value of soluble urokinase-type plasminogen activator receptor for mortality in patients with suspected myocardial infarction.

Clin Res Cardiol 2019 Apr 16. Epub 2019 Apr 16.

Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: Early risk stratification of patients with suspected acute myocardial infarction (AMI) constitutes an unmet need in current daily clinical practice. We aimed to evaluate the predictive value of soluble urokinase-type plasminogen activator receptor (suPAR) levels for 1-year mortality in patients with suspected AMI.

Methods And Results: suPAR levels were determined in 1314 patients presenting to the emergency department with suspected AMI. Read More

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http://dx.doi.org/10.1007/s00392-019-01475-1DOI Listing
April 2019
1 Read

Left atrial appendage occlusion in patients with atrial fibrillation and high risk of fall: a clinical dilemma or a budgetary issue?

Clin Res Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Vivantes Klinikum im Friedrichshain und Am Urban, Dieffenbachstraße 1, 10967, Berlin, Germany.

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http://dx.doi.org/10.1007/s00392-019-01476-0DOI Listing
April 2019
1 Read

Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals.

Clin Res Cardiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine III, Institute for Cardiomyopathy, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.

Background: Left ventricular non-compaction has been increasingly diagnosed in recent years. However, it is still debated whether non-compaction is a pathological condition or a physiological trait. In this meta-analysis and systematic review, we compare studies, which investigated these two different perspectives. Read More

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http://dx.doi.org/10.1007/s00392-019-01465-3DOI Listing
April 2019
1 Read

Age-dependent differences in clinical phenotype and prognosis in heart failure with mid-range ejection compared with heart failure with reduced or preserved ejection fraction.

Clin Res Cardiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: HFmrEF has been recently proposed as a distinct HF phenotype. How HFmrEF differs from HFrEF and HFpEF according to age remains poorly defined. We aimed to investigate age-dependent differences in heart failure with mid-range (HFmrEF) vs. Read More

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http://dx.doi.org/10.1007/s00392-019-01477-zDOI Listing

Aortic annulus measurement with computed tomography angiography reduces aortic regurgitation after transfemoral aortic valve replacement compared to 3-D echocardiography: a single-centre experience.

Clin Res Cardiol 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Department of Internal Medicine I, University Hospital Jena, Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany.

Background: Accurate assessment of the aortic annulus is crucial for successful transcatheter aortic valve replacement (TAVR), in particular to prevent paravalvular regurgitation (PVR). We compared aortic annular sizing using multidetector computed tomography (MDCT) and three-dimensional transoesophageal echocardiography (3-D TEE) to determine the predictive value of MDCT.

Methods And Results: All patients admitted for transfemoral TAVR [n = 227; 48. Read More

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http://link.springer.com/10.1007/s00392-019-01462-6
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http://dx.doi.org/10.1007/s00392-019-01462-6DOI Listing
April 2019
3 Reads

Does rhythm matter in acute heart failure? An insight from the British Society for Heart Failure National Audit.

Clin Res Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, University of Keele and Royal Stoke Hospital, Stoke-on-Trent, UK.

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with acute heart failure (AHF). The presence of AF is associated with adverse prognosis in patients with chronic heart failure (CHF) but little is known about its impact in AHF.

Methods: Data were collected between April 2007 and March 2013 across 185 (> 95%) hospitals in England and Wales from patients with a primary death or a discharge diagnosis of AHF. Read More

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http://dx.doi.org/10.1007/s00392-019-01463-5DOI Listing
April 2019
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Role of percutaneous edge-to-edge repair in secondary mitral regurgitation after MITRA-FR and COAPT : A comment by the section of AV-valve treatment of the Working Group of Interventional Cardiology (AGIK) of the German Society of Cardiology (DGK).

Clin Res Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1007/s00392-019-01457-3DOI Listing
April 2019
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Effect of baroreflex activation therapy on renal sodium excretion in patients with resistant hypertension.

Clin Res Cardiol 2019 Apr 6. Epub 2019 Apr 6.

Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Objective: Activation of the sympathetic nervous system increases sodium retention in resistant hypertension. Baroreflex activation therapy (BAT) is an interventional method to reduce sympathetic overactivity in patients with resistant hypertension. This study aimed to assess the effect of BAT on urinary sodium excretion. Read More

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http://dx.doi.org/10.1007/s00392-019-01464-4DOI Listing
April 2019
1 Read

Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy?

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Angiology and Respiratory Medicine, Amyloidosis Center, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Background: Carpal tunnel syndrome (CTS) and spinal canal stenosis can be frequently observed in the medical history of patients with transthyretin amyloidosis (ATTR), both in the hereditary (mt-ATTR) and wild-type (wt-ATTR) form. The aim of this retrospective single-center analysis was to determine the prevalence of these findings, delay to diagnosis of systemic amyloidosis and the prognostic value in a large cohort of patients with wt-ATTR and mt-ATTR amyloidosis.

Methods: Medical records of 253 patients diagnosed with wt-ATTR, 136 patients with mt-ATTR and 77 asymptomatic gene carriers were screened for history of CTS and spinal canal stenosis and laboratory analysis, electrocardiography and echocardiographic results, respectively. Read More

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http://dx.doi.org/10.1007/s00392-019-01467-1DOI Listing
April 2019
1 Read

Body mass index and all-cause mortality in patients with atrial fibrillation: insights from the China atrial fibrillation registry study.

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: Impact of body mass index (BMI) on all-cause mortality in atrial fibrillation (AF) patients remains controversial.

Methods: A total of 10,942 AF patients were prospectively enrolled and categorized into four BMI groups: underweight (BMI < 18.5 kg/m), normal weight (BMI 18. Read More

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http://dx.doi.org/10.1007/s00392-019-01473-3DOI Listing
April 2019
3 Reads

Mean BMI, visit-to-visit BMI variability and BMI changes during follow-up in patients with acute myocardial infarction with systolic dysfunction and/or heart failure: insights from the High-Risk Myocardial Infarction Initiative.

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Université de Lorraine, INSERM, Centre d'Investigation Clinique et Plurithématique 1433, INSERM U1116, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Background: In patients with acute myocardial infarction (MI), BMI < 18.5 kg/m and a decrease in BMI during follow-up have been associated with poor prognosis. For BMI ≥ 25 kg/m, an "obesity paradox" has been suggested. Read More

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http://dx.doi.org/10.1007/s00392-019-01453-7DOI Listing
April 2019
2 Reads

Procedural success, safety and patients satisfaction after second ablation of atrial fibrillation in the elderly: results from the German Ablation Registry.

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.

Background: Aged patients are underrepresented in clinical trials on catheter ablation of atrial fibrillation (AF). In addition, results of outcomes after repeat ablation in the elderly are lacking. We report the results of first repeat AF ablation procedures of aged patients from a real-world multicenter prospective registry. Read More

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http://dx.doi.org/10.1007/s00392-019-01471-5DOI Listing
April 2019
1 Read

Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study.

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, cardiovascular risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, and all-cause mortality in the general population. Thus, we aimed to investigate these relationships in a population-based cohort. Read More

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http://dx.doi.org/10.1007/s00392-019-01466-2DOI Listing
April 2019
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Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study.

Clin Res Cardiol 2019 Apr 4. Epub 2019 Apr 4.

Klinik für Innere Medizin IV, Abteilung für Nieren-und Hochdruckkrankheiten, Universitätsklinikum des Saarlandes, Homburg, Saar, Germany.

Importance: A more precise identification of patients at "high cardiovascular risk" is preeminent in cardiovascular risk stratification.

Objective: To investigate the relationships between markers of cholesterol homeostasis, cardiovascular events and all-cause mortality.

Design, Setting And Participants: We quantified markers of cholesterol homeostasis by gas chromatography-mass spectrometry in 377 subjects with suspected coronary artery disease, who were not on lipid-lowering drugs at baseline. Read More

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http://dx.doi.org/10.1007/s00392-019-01474-2DOI Listing
April 2019
2 Reads

Patient preference for therapies in hypertension: a cross-sectional survey of German patients.

Clin Res Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany.

Background: Hypertension is poorly controlled in numerous patients despite effective medication being available. Catheter-based renal denervation (RDN) has emerged as an alternative treatment option. We aimed to assess how likely patients with elevated blood pressure (BP) are to accept RDN as treatment option. Read More

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http://dx.doi.org/10.1007/s00392-019-01468-0DOI Listing

Cardiac surgery 2018 reviewed.

Clin Res Cardiol 2019 Mar 30. Epub 2019 Mar 30.

Department of Cardiothoracic Surgery, Friedrich-Schiller-University of Jena, Am Klinikum 1, 07747, Jena, Germany.

For the year 2018, more than 22,000 published references can be found in PubMed when entering the search term "cardiac surgery". As in the last 4 years, this review focusses on conventional cardiac surgery publications which provide important and interesting information especially relevant for non-surgical colleagues. Interventional techniques have been considered if they were published in the context of classic surgical techniques. Read More

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http://dx.doi.org/10.1007/s00392-019-01470-6DOI Listing
March 2019
3 Reads

Impact of valvular resistance on aortic regurgitation after transcatheter aortic valve replacement according to the type of prosthesis.

Clin Res Cardiol 2019 Mar 30. Epub 2019 Mar 30.

Department of Cardiology, Swiss Cardiovascular Center, Bern University Hospital, Freibrugstrasse, 3010, Bern, Switzerland.

Background: The impact of aortic valvular resistance (VR) on the degree of post-transcatheter aortic valve replacement (TAVR) aortic regurgitation (AR) remains unclear. The objective of the study was to investigate the relationship between VR and paravalvular AR after TAVR.

Methods: Between August 2007 and December 2015, 708 TAVR patients had sufficient data to calculate VR before the intervention and were eligible for the present analysis. Read More

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http://dx.doi.org/10.1007/s00392-019-01469-zDOI Listing
March 2019
2 Reads

Coronary microvascular dysfunction in patients with acute coronary syndrome and no obstructive coronary artery disease.

Clin Res Cardiol 2019 Mar 29. Epub 2019 Mar 29.

Department of Cardiovascular Disease, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Istituto di Cardiologia, Largo A. Gemelli, 8, 00168, Rome, Italy.

Background: Between 10 and 15% of patients admitted for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) show no obstructive coronary artery disease (NO-CAD) at angiography. Coronary microvascular spasm is a possible mechanism of the syndrome, but there are scarce data about coronary microvascular function in these patients.

Objectives: To assess coronary microvascular function in patients with NSTE-ACS and NO-CAD. Read More

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http://dx.doi.org/10.1007/s00392-019-01472-4DOI Listing
March 2019
3 Reads

Feasibility of entirely subcutaneous ICD™ systems in patients with coronary artery disease.

Clin Res Cardiol 2019 Mar 21. Epub 2019 Mar 21.

Clinic for Cardiology II: Electrophysiology, University Hospital Münster, Münster, Germany.

Background: The subcutaneous ICD (S-ICD™) is an important advance in device therapy for the prevention of sudden cardiac death (SCD). Although current guidelines recommend S-ICD™ use, long-term data are still limited, especially in subgroups. Among several cardiac diseases that prone to SCD, coronary artery disease (CAD) carries several peculiarities that may hamper S-ICD™ therapy in this cohort. Read More

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http://dx.doi.org/10.1007/s00392-019-01455-5DOI Listing
March 2019
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Mechanical circulatory support with Impella versus intra-aortic balloon pump or medical treatment in cardiogenic shock-a critical appraisal of current data.

Clin Res Cardiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Charité-Universitaetsmedizin Berlin, Berlin, Germany.

Aims: Patients suffering from cardiogenic shock (CS) have a high mortality and morbidity. The Impella percutaneous left-ventricular assist device (LVAD) decreases LV preload, increases cardiac output, and improves coronary blood flow. We aimed to review and meta-analyze available data comparing Impella versus intra-aortic pump (IABP) counterpulsation or medical treatment in CS due to acute myocardial infarction or post-cardiac arrest. Read More

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http://dx.doi.org/10.1007/s00392-019-01458-2DOI Listing
March 2019
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Angiotensin-converting-enzyme inhibitors in hemodynamic congestion: a meta-analysis of early studies.

Clin Res Cardiol 2019 Mar 20. Epub 2019 Mar 20.

Institut für Medizinische Biometrie und Statistik, ZKS Lübeck, Universität zu Lübeck, Lübeck, Germany.

Aim: Major clinical trials have shown that angiotensin-converting enzyme (ACE) inhibitors reduce mortality and morbidity in congestive heart failure (HF). Prior to these seminal findings hemodynamic effects of ACE inhibitors were examined in small studies. We aimed to review these studies systematically and meta-analyze the effects of ACE inhibitors on hemodynamics in HF. Read More

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http://dx.doi.org/10.1007/s00392-019-01456-4DOI Listing
March 2019
2 Reads

Epicardial fat accumulation is an independent marker of impaired heart rate recovery in obese patients with obstructive sleep apnea.

Clin Res Cardiol 2019 Mar 18. Epub 2019 Mar 18.

Department of Cardiology, CHU Martinique, University Hospital of Martinique, Antilles University, 97200, Fort de France, France.

Background: Sympathetic nervous system activation plays a pivotal role in obese patients with obstructive sleep apnea (OSA), contributing to increased cardiovascular risk. Epicardial adipose tissue (EAT) activates cardiac autonomic nervous system. Our main study objective was to investigate effects of these autonomic dysfunction factors on post-exercise heart rate recovery (HRR). Read More

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http://dx.doi.org/10.1007/s00392-019-01454-6DOI Listing
March 2019
3 Reads

Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices.

Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

Department of Internal Medicine III, Division of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Background: Ventricular assist devices (VAD) are increasingly used as long-term treatment for advanced heart failure. However, survival after VAD implantation is still unsatisfactory, and no specific outpatient follow-up algorithms have been formally established. Here, we evaluate the effect of an intensified follow-up protocol (IFUP) on survival rates and VAD-associated complications. Read More

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http://dx.doi.org/10.1007/s00392-019-01451-9DOI Listing
March 2019
1 Read

Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome.

Clin Res Cardiol 2019 Mar 16. Epub 2019 Mar 16.

First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Background: Short QT syndrome (SQTS) is associated with sudden cardiac death and implantable cardioverter-defibrillator (ICD) implantation is recommended in this rare disease. However, only a few SQTS families have been reported in literature with limited follow-up data.

Objectives: In the recent study, we describe the outcome data of 57 SQTS patients receiving ICD implantation. Read More

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http://dx.doi.org/10.1007/s00392-019-01449-3DOI Listing
March 2019
1 Read

Implant-based multi-parameter telemonitoring of patients with heart failure and a defibrillator with vs. without cardiac resynchronization therapy option: a subanalysis of the IN-TIME trial.

Clin Res Cardiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.

Aims: In the IN-TIME trial, automatic daily implant-based multiparameter telemonitoring significantly improved clinical outcomes in patients with chronic systolic heart failure and implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D). We compared IN-TIME results for ICD and CRT-D subgroups.

Methods: Patients with LVEF ≤ 35%, NYHA class II/III, optimized drug treatment, no permanent atrial fibrillation, and a dual-chamber ICD (n = 274) or CRT-D (n = 390) were randomized 1:1 to telemonitoring or no telemonitoring for 12 months. Read More

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http://dx.doi.org/10.1007/s00392-019-01447-5DOI Listing
March 2019
2 Reads

Biventricular myocardial strain analysis using cardiac magnetic resonance feature tracking (CMR-FT) in patients with distinct types of right ventricular diseases comparing arrhythmogenic right ventricular cardiomyopathy (ARVC), right ventricular outflow-tract tachycardia (RVOT-VT), and Brugada syndrome (BrS).

Clin Res Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.

Objectives: As underlying heart diseases of right ventricular tachyarrhythmias, ARVC causes wall-motion abnormalities based on fibrofatty myocardial degeneration, while RVOT-VT and BrS are thought to lack phenotypic MR characteristics. To examine whether cardiac magnetic resonance (CMR) feature tracking (FT) in addition to ARVC objectively facilitates detection of myocardial functional impairments in RVOT-VT and BrS.

Methods: Cine MR datasets of four retrospectively enrolled, age-matched study groups [n = 65; 16 ARVC, 26 RVOT-VT, 9 BrS, 14 healthy volunteers (HV)] were independently assessed by two distinctly experienced investigators regarding myocardial function using CMR-FT. Read More

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http://dx.doi.org/10.1007/s00392-019-01450-wDOI Listing
March 2019
3 Reads

Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function.

Clin Res Cardiol 2019 Mar 11. Epub 2019 Mar 11.

2nd Department of Cardiology, Medical School, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background: Anakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis. We investigated the differential effects of anakinra and tocilizumab on myocardial and vascular function in an atherosclerosis model of patients with rheumatoid arthritis.

Methods: 120 patients with rheumatoid arthritis were randomized to anakinra (n = 40), tocilizumab (n = 40) or prednisolone (n = 40) for 3 months. Read More

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http://dx.doi.org/10.1007/s00392-019-01443-9DOI Listing
March 2019
1 Read

Cardioprotective effect of renin-angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity.

Clin Res Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Trastuzumab-related cardiotoxicity (TRC) has been considered as reversible. However, recent studies have raised concern against reversibility of left ventricular (LV) systolic dysfunction in breast cancer patients treated with trastuzumab. In addition, the efficacy of medical treatment for heart failure (HF) including renin-angiotensin inhibitors and β-blockers has not been defined in TRC. Read More

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http://dx.doi.org/10.1007/s00392-019-01448-4DOI Listing

Thrombus aspiration in patients with ST-elevation myocardial infarction presenting late after symptom onset: long-term clinical outcome of a randomized trial.

Clin Res Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany.

Background: In the largest randomized trial so far, thrombus aspiration failed to reduce the primary endpoint of microvascular obstruction (MVO) in patients with ST-elevation myocardial infarction (STEMI) presenting late after symptom onset. Long-term clinical outcome data of this trial have not been reported yet.

Methods And Results: A total of 144 patients with STEMI presenting ≥ 12 and ≤ 48 h after symptom onset were randomized to primary percutaneous coronary intervention (PCI) with or without manual thrombus aspiration in a 1:1 fashion. Read More

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http://dx.doi.org/10.1007/s00392-019-01452-8DOI Listing

Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study.

Clin Res Cardiol 2019 Feb 28. Epub 2019 Feb 28.

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.

Aims: The electrocardiographic pattern of early repolarization (ER) is related to increased cardiac mortality in the general population. The pathophysiological basis of ER is largely unknown. We investigated the association of echocardiographic structural and functional parameters of the left ventricle with the presence of ER in the community. Read More

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http://dx.doi.org/10.1007/s00392-019-01445-7DOI Listing
February 2019

Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review.

Clin Res Cardiol 2019 Feb 26. Epub 2019 Feb 26.

Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, 4th floor Chris Barnard Building, Observatory, Cape Town, 7935, South Africa.

Hormones have a vital duty in the conservation of physiological cardiovascular function during pregnancy. Alterations in oestrogen, progesterone and prolactin levels are associated with changes in the cardiovascular system to support the growing foetus and counteract pregnancy stresses. Pregnancy hormones are, however, also linked to numerous pathophysiological outcomes on the cardiovascular system. Read More

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http://dx.doi.org/10.1007/s00392-019-01441-xDOI Listing
February 2019

Higher prevalence of heart failure in rural regions: a population-based study covering 87% of German inhabitants.

Clin Res Cardiol 2019 Feb 23. Epub 2019 Feb 23.

Department of Regional Health Care Analysis and Health Care Atlas, Central Research Institute of Ambulatory Health Care in Germany (ZI), Salzufer 8, 10587, Berlin, Germany.

Background: So far the extent of regional variation of heart failure (HF) prevalence in Germany is unknown.

Methods: Using a full sample of nationwide claims data covering ambulatory care of approximately 87% of the German population, this study aimed to (i) examine regional differences of HF prevalence on the level of 402 German administrative districts and (ii) investigate factors associated with HF prevalence. This study included all statutory health-insured patients aged ≥ 40 years in 2017, comprising about 40 million individuals. Read More

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http://dx.doi.org/10.1007/s00392-019-01444-8DOI Listing
February 2019

Digitalis therapy is associated with higher comorbidities and poorer prognosis in patients undergoing ablation of atrial arrhythmias: data from the German Ablation Registry.

Clin Res Cardiol 2019 Feb 23. Epub 2019 Feb 23.

Clinic for Cardiology II - Electrophysiology, University of Münster, Münster, Germany.

Background: Digitalis glycosides are employed for rate control of atrial fibrillation. Recent studies suggested potential harmful effects of digitalis monotherapy and combination with antiarrhythmic drugs. The aim of the present study was to assess the prevalence and potential impact of digitalis therapy on outcome in patients undergoing catheter ablation of supraventricular arrhythmias. Read More

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http://dx.doi.org/10.1007/s00392-019-01442-wDOI Listing
February 2019

Non-cardiac comorbidities and mortality in patients with heart failure with reduced vs. preserved ejection fraction: a study using the Swedish Heart Failure Registry.

Clin Res Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 416 85, Gothenburg, Sweden.

Background: Heart failure (HF) and non-cardiac comorbidities often coexist and are known to have an adverse effect on outcome. However, the prevalence and prognostic impact of non-cardiac comorbidities in patients with HF with reduced ejection fraction (HFrEF) vs. those with preserved (HFpEF) remain inadequately studied. Read More

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http://dx.doi.org/10.1007/s00392-019-01430-0DOI Listing
February 2019
1 Read

Sacubitril/valsartan reduces ventricular arrhythmias in parallel with left ventricular reverse remodeling in heart failure with reduced ejection fraction.

Clin Res Cardiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Cardiology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600, Genk, Belgium.

Background: Sacubitril/valsartan reduced the occurrence of sudden cardiac death in the PARADIGM-HF trial. However, limited information is available about the mechanism.

Methods: Heart failure (HF)-patients receiving sacubitril/valsartan for a class-I indication equipped with an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT) with remote tele-monitoring were retrospectively analyzed. Read More

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http://link.springer.com/10.1007/s00392-019-01440-y
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http://dx.doi.org/10.1007/s00392-019-01440-yDOI Listing
February 2019
9 Reads

Atrial fibrillation ablation strategies and outcome in patients with heart failure: insights from the German ablation registry.

Clin Res Cardiol 2019 Feb 20. Epub 2019 Feb 20.

University Heart Center Lübeck, Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Background: Heart failure (HF) and atrial fibrillation (AF) often coexist, but data on the prognostic value of differing ablation strategies according to left ventricular ejection fraction (LVEF) are rare.

Methods And Results: From January 2007 until January 2010, 728 patients with HF were enrolled in the multi-center German ablation registry prior to AF catheter ablation. Patients were divided into three groups according to LVEF: HF with preserved LVEF (≥ 50%, HFpEF, n = 333), mid-range LVEF (40-49%, HFmrEF, n = 207), and reduced LVEF (< 40%, HFrEF, n = 188). Read More

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http://dx.doi.org/10.1007/s00392-019-01411-3DOI Listing
February 2019
1 Read

Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis.

Clin Res Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Deutsches Herzzentrum München, Klinik an der Technischen Universität München, Munich, Germany.

Aims: To describe optical coherence tomography (OCT) findings in patients with in-stent restenosis (ISR) and determine predictors of neointimal patterns and neoatherosclerosis.

Methods And Results: Patients undergoing OCT prior to PCI for ISR in three European centres were included. Analyses were performed in a core laboratory. Read More

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http://dx.doi.org/10.1007/s00392-019-01439-5DOI Listing
February 2019
1 Read

Doxorubicin treatments induce significant changes on the cardiac autonomic nervous system in childhood acute lymphoblastic leukemia long-term survivors.

Clin Res Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Laboratoire de Physiopathologie de l'EXercice (LPEX), Département de Kinésiologie, Université de Montréal, CEPSUM, 2100, boulevard Édouard Montpetit, H3C 3J7, Montreal, QC, Canada.

Aims: Acute lymphoblastic leukemia (ALL) is one of the leading malignancies in children worldwide. The cardiotoxicity of anti-cancer treatments leads to a dysfunction of the cardiac autonomic nervous system. Protection strategies, with dexrazoxane treatments, were used to counter these adverse effects. Read More

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http://link.springer.com/10.1007/s00392-019-01427-9
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http://dx.doi.org/10.1007/s00392-019-01427-9DOI Listing
February 2019
4 Reads

Relation of lowering door-to-balloon time and mortality in ST segment elevation myocardial infarction patients undergoing percutaneous coronary intervention.

Clin Res Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Division of Cardiovascular Diseases and Internal Medicine, Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizmann Street, Tel-Aviv, Israel.

Background: Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend a door-to-balloon time (DBT) of ≤ 90 min for patients undergoing primary percutaneous coronary intervention (PCI). We aimed to investigate the possible impact of further reduction in DBT intervals beyond the 90 min cutoff on short and long-term outcomes among STEMI patients undergoing primary PCI.

Methods: We retrospectively studied 889 STEMI patients (median age 61 years, 83% men) who underwent successful primary PCI and had a DBT of ≤ 90 min. Read More

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http://dx.doi.org/10.1007/s00392-019-01438-6DOI Listing
February 2019
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Risk of cardiac arrhythmias after electrical accident: a single-center study of 480 patients.

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Semmelweis University Heart and Vascular Centre, Városmajor u. 68, Budapest, 1122, Hungary.

Objective: Patients with electrical injury are considered to be at high risk of cardiac arrhythmias. Due to the small number of studies, there is no widely accepted guideline regarding the risk assessment and management of arrhythmic complications after electrical accident (EA). Our retrospective observational study was designed to determine the prevalence of ECG abnormalities and cardiac arrhythmias after EA, to evaluate the predictive value of cardiac biomarkers for this condition and to assess in-hospital and 30-day mortality. Read More

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http://dx.doi.org/10.1007/s00392-019-01420-2DOI Listing
February 2019
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Uptake in antithrombotic treatment and its association with stroke incidence in atrial fibrillation: insights from a large German claims database.

Clin Res Cardiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany.

Background: Underuse of oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF) results in thousands of preventable strokes in Germany each year. This study aimed to assess changes in antithrombotic therapy in AF patients after increased use of direct oral anticoagulants (DOACs) in Germany and to evaluate whether the adoption of DOAC therapy was associated with changes in AF-related stroke and bleeding over time.

Methods: Analyses were carried out on a large claims-based dataset of 4 million health-insured Germans. Read More

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http://dx.doi.org/10.1007/s00392-019-01437-7DOI Listing
February 2019
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Non-invasive evaluation of the relationship between electrical and structural cardiac abnormalities in patients with myotonic dystrophy type 1.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology I, University Hospital Muenster, Münster, Germany.

Background: Cardiac involvement in myotonic dystrophy type 1 (MD1) includes conduction disease, arrhythmias, and left-ventricular (LV) systolic dysfunction leading to an increased sudden cardiac death risk. An understanding of the interplay between electrical and structural myocardial changes could improve the prediction of adverse cardiac events. We aimed to explore the relationship between signs of cardiomyopathy by conventional and advanced cardiovascular magnetic resonance (CMR), and electrical abnormalities in MD1. Read More

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http://dx.doi.org/10.1007/s00392-019-01414-0DOI Listing
February 2019
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Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiovascular Sciences, Clinical Sciences Wing, NIHR Leicester Biomedical Research Centre, Glenfield Hospital, University of Leicester, Leicester, LE3 9QP, UK.

Background: Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure with preserved ejection fraction (HFpEF), and its relationship to renal function, Body Mass Index (BMI), and imaging measures of diastolic dysfunction.

Methods: In this multicentre study, PENK was measured in 522 HFpEF patients (ejection fraction > 50%, 253 male, mean age 76. Read More

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http://dx.doi.org/10.1007/s00392-019-01424-yDOI Listing
February 2019
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Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Cardiovascular Research Laboratory, Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments have been identified that can modify disease progression. This unmet medical need is likely attributed to an incomplete understanding of the molecular mechanism driving disease development. Read More

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http://dx.doi.org/10.1007/s00392-019-01413-1DOI Listing
February 2019
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Atrial high rate episodes in patients with cardiac implantable electronic devices: implications for clinical outcomes.

Clin Res Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.

Background: Atrial high rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are associated with an increased risk of stroke. However, the impact of AHRE on improving stroke risk stratification scheme remains uncertain.

Objective: The purpose of this study was to assess the impact of AHRE on prognosis in relation with cardiovascular events and risk stratification. Read More

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http://dx.doi.org/10.1007/s00392-019-01432-yDOI Listing
February 2019
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Severe eosinophilic myocarditis associated with modafinil in a patient with normal peripheral eosinophil count.

Clin Res Cardiol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00392-019-01434-wDOI Listing
February 2019
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4.560 Impact Factor

Prognostic impact of recurrences of ventricular tachyarrhythmias and appropriate ICD therapies in a high-risk ICD population.

Clin Res Cardiol 2019 Feb 12. Epub 2019 Feb 12.

First Department of Medicine, Faculty of Medicine Mannheim, European Center for AngioScience (ECAS), and DZHK, University Medical Centre Mannheim (UMM), University of Heidelberg, German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: The study sought to evaluate the prognostic impact of recurrences of ventricular tachyarrhythmias in consecutive ICD recipients with ventricular tachyarrhythmias on admission.

Methods: All consecutive patients surviving at least one episode of ventricular tachyarrhythmias from 2002 to 2016 and discharged with an ICD (pre-existing ICD or ICD implantation at index hospitalization) were included. The primary endpoint was all-cause mortality according to the presence or absence of recurrences of ventricular tachyarrhythmias at 5 years. Read More

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http://dx.doi.org/10.1007/s00392-019-01416-yDOI Listing
February 2019
2 Reads
4.560 Impact Factor

Transcatheter aortic valve replacement for pure aortic valve regurgitation: "on-label" versus "off-label" use of TAVR devices.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiology, University Heart Center Berlin and Charité University Medicine Berlin, Campus Benjamin-Franklin, Berlin, Germany.

Introduction: Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for aortic stenosis in patients with high surgical risk. Pure aortic regurgitation (PAR) is considered a relative contraindication for TAVR; however, TAVR is increasingly performed in PAR patients with unfavorable risk profile. Herein, we aim to summarize available data on TAVR for PAR with special emphasis on "on-label" versus "off-label" TAVR devices. Read More

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http://dx.doi.org/10.1007/s00392-019-01422-0DOI Listing
February 2019
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Association between atrial fibrillation and Helicobacter pylori.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht -CARIM, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

The connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. Read More

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http://dx.doi.org/10.1007/s00392-019-01418-wDOI Listing
February 2019
1 Read