4,309,016 results match your criteria Clinical Pharmacology: Advances and Applications [Journal]


Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Background And Aim: The treat-to-target strategy has emerged in ulcerative colitis management. Mucosal healing is the best target, albeit not in induction therapy of acute diseases as clinical conditions vary over a short duration. To determine the targets during induction therapy for acute ulcerative colitis, we identified markers to predict mucosal healing at 3 and 12 months of initiating the induction therapy. Read More

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December 2018

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018

Centrifugation affects the purity of liquid biopsy-based tumor biomarkers.

Cytometry A 2018 Dec;93(12):1207-1212

Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Clinical Chemistry, Amsterdam, the Netherlands.

Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. Read More

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December 2018

[Failure Prevention and Management of Complications after Proximal Femoral Fractures].

Z Orthop Unfall 2018 Dec 14;156(6):725-740. Epub 2018 Dec 14.

Background: Proximal femoral fractures belong to the most common fractures, especially of the elderly. There is a high load of cases and most of them have to be treated surgically. With 20% and above, the rate of complications is very high. Read More

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December 2018

[Megaimplants of the Proximal Femur: Current Concepts].

Z Orthop Unfall 2018 Dec 14;156(6):685-691. Epub 2018 Dec 14.

Klinik und Poliklinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar, Technische Universität München.

In addition to their outstanding significance in the field of tumor orthopaedics, megaprostheses are becoming increasingly important for revision arthroplasty. Despite their wide application, the reported complication and failure rates remain high. The analysis of failure mechanisms roughly allows a breakdown into mechanical and non-mechanical causes; soft-tissue failure, loosening and periprosthetic infection play outstanding roles. Read More

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December 2018

Association of Antenatal Depression with Clinical Subtypes of Preterm Birth.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.

Objective:  To estimate the association between antenatal depression and spontaneous preterm birth (SPTB) relative to medically indicated preterm birth (MPTB).

Study Design:  This was a secondary analysis of a nested case-control study of preterm birth (PTB). The exposure was a clinical diagnosis of antenatal depression. Read More

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December 2018

Cardiovascular and Metabolic Risk in Women in the First Year Postpartum: Allostatic Load as a Function of Race, Ethnicity, and Poverty Status.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.

Objective:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.

Methods:  The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers. Read More

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December 2018

Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

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December 2018

A Diagnostic Challenge: Prenatal Ultrasound Findings in Severe Epidermolysis Bullosa.

Ultraschall Med 2018 Dec 14;39(6):600-601. Epub 2018 Dec 14.

Ultraschallpraxis Freie Strasse, Basel, Switzerland.

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December 2018

The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Read More

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December 2018

Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Commentary: Writing a Clinical Research Question.

Neurosurgery 2019 Jan;84(1):17-18

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama.

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January 2019

Network localization of heterogeneous neuroimaging findings.

Brain 2018 Dec 14. Epub 2018 Dec 14.

Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA.

Studies of the same disease often implicate different brain regions, contributing to a perceived reproducibility crisis in neuroimaging. Here, we leverage the normative human brain connectome to test whether seemingly heterogeneous neuroimaging findings localize to connected brain networks. We use neurodegenerative disease, and specifically Alzheimer's disease, as our example as it is one of the diseases that has been studied the most using neuroimaging. Read More

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December 2018

Work Loss Before and After Diagnosis of Crohn's Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: The aim of this study was to examine work loss in patients with Crohn's disease.

Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More

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December 2018
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Two Extraordinary Sellar Neuronal Tumors: Literature Review and Comparison of Clinicopathologic Features.

Am J Clin Pathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Duke University Medical Center, Durham, NC.

Objectives: The list of tumors involving the pituitary gland has been expanded to include a variety of neuronal and paraneuronal tumors in the 2017 World Health Organization tumor classification of endocrine organs. All the entities included in this category are distinctly rare, with limited case reports in the literature.

Methods: We illustrate two extraordinary sellar tumors with neuronal differentiation: a sellar paraganglioma and a sellar neurocytoma, with thorough literature review and comparison of the clinicopathologic features of these entities. Read More

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December 2018

CRISPR-C: circularization of genes and chromosome by CRISPR in human cells.

Nucleic Acids Res 2018 Dec;46(22):e131

Department of Biomedicine, Aarhus University, Denmark.

Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations found in humans with genetic disorders. However, there is a lack of genetic engineering tools to recapitulate and study the biogenesis of eccDNAs. Here, we created a dual-fluorescence biosensor cassette, which upon the delivery of pairs of CRISPR/Cas9 guide RNAs, CRISPR-C, allows us to study the biogenesis of a specific fluorophore expressing eccDNA in human cells. Read More

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December 2018

Expostats: A Bayesian Toolkit to Aid the Interpretation of Occupational Exposure Measurements.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Introduction: Interpretation of exposure measurements has evolved into a framework based on the lognormal distribution. Most available practical tools are based on traditional frequentist statistical procedures that do not satisfactorily account for censored data and are not amenable to simple probabilistic risk statements. Bayesian methods offer promising solutions to these challenges. Read More

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December 2018

Increased incidence rate of hypothyroidism after iodine fortification in Denmark. A 20 year prospective population-based study.

J Clin Endocrinol Metab 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Aalborg University Hospital, Denmark.

Objective: To monitor the impact of a cautious iodine fortification (IF) on the incidence of overt hypothyroidism in two sub-populations with different levels of preexisting iodine deficiency (ID).

Design: A 20 years (1997-2016) prospective population-based study identified all new cases of diagnosed overt biochemical hypothyroidism in two open cohorts: a Western cohort with moderate ID (n=309,434, January 1st, 1997) and an Eastern cohort with mild ID (n=224,535, January 1st, 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas and possible new cases were verified individually. Read More

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December 2018

Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome.

Rheumatology (Oxford) 2019 Jan;58(1):103-109

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.

Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More

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January 2019

Elagolix for endometriosis: all that glitters is not gold.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Via Commenda, 12, 20122 Milan, Italy.

Elagolix, an orally active non-peptidic GnRH antagonist, has been approved by the Food and Drug Administration for the management of moderate to severe pain associated with endometriosis. As the degree of ovarian suppression obtained with elagolix is dose-dependent, pain relief may be achieved by modulating the level of hypo-oestrogenism while limiting side effects. Elagolix may thus be considered a novelty in terms of its endocrine and pharmacological properties but not for its impact on the pathogenic mechanisms of endometriosis, as the target of this new drug is, yet again, alteration of the hormonal milieu. Read More

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December 2018

2018 Infectious Diseases Society of America Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy.

Clin Infect Dis 2019 Jan;68(1):1-4

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, and Center for Evidence-based Practice, University of Pennsylvania Health System, Philadelphia.

A panel of experts was convened by the Infectious Diseases Society of America to update the 2004 clinical practice guideline on outpatient parenteral antimicrobial therapy (OPAT) [1]. This guideline is intended to provide insight for healthcare professionals who prescribe and oversee the provision of OPAT. It considers various patient features, infusion catheter issues, monitoring questions, and antimicrobial stewardship concerns. Read More

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January 2019

Disease Severity and Depressive Symptoms in Adolescents With Inflammatory Bowel Disease: The Mediating Role of Parent and Youth Illness Uncertainty.

J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.

Oklahoma State University.

Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD).

Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1. Read More

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December 2018

The Acute Impact of Hatha Yoga on Craving among Smokers Attempting to Reduce or Quit.

Nicotine Tob Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, Louisiana State University, Baton Rouge, LA, USA.

Introduction: Despite negative effects of smoking, smokers have difficulty quitting, suggesting a need for additional strategies to help them quit. A single-session hatha yoga intervention acutely reduced craving among nicotine-deprived smokers not attempting to reduce or quit, yet it is unknown if it reduces craving among those attempting to change their smoking. Thus, the current study tested the efficacy of a single-session hatha yoga intervention for acutely reducing craving among smokers attempting to reduce or quit smoking. Read More

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December 2018

Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease.

J Crohns Colitis 2018 Dec 14. Epub 2018 Dec 14.

The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA.

Background And Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies. Read More

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December 2018

Epidemiology of shoulder injury in sub-elite level water polo players.

Phys Ther Sport 2018 Dec 5;35:127-132. Epub 2018 Dec 5.

Research Institute for Sport and Exercise University of Canberra, Building 1, 11 Kirinari Street, Bruce, ACT, 2617, Australia. Electronic address:

Objective: Investigate the patterns and circumstances of shoulder injury, in both male and female sub-elite water polo players, through evaluating the injury incidence, mechanism and subsequent training time lost.

Design: Retrospective cohort.

Setting: Sports institute. Read More

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December 2018

Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study.

Nutrition 2018 Oct 12;60:106-111. Epub 2018 Oct 12.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients.

Methods: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention. Read More

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October 2018

Why do current strategies for optimal nutritional therapy neglect the microbiome?

Nutrition 2018 Oct 5;60:100-105. Epub 2018 Oct 5.

Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.

Strategies for providing optimal nutritional therapy have evolved over time, with the emphasis on specific directives (such as route, use of immunonutrition, high protein, organ-specific formulas, etc.), achieving variable degrees of success for improving outcomes in the intensive care unit. As the largest immune organ in the body comprising the largest interface between the host and the external environment, the gut can have an amplifying effect on a pattern of dysbiosis, immune dysregulation, and multiple organ failure seen in the critically ill patient. Read More

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October 2018

MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.

Biomed Pharmacother 2018 Dec 11;110:656-666. Epub 2018 Dec 11.

Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China. Electronic address:

Background: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. Read More

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December 2018

Origin of neck pain and direction of movement influence dynamic cervical joint motion and pressure pain sensitivity.

Clin Biomech (Bristol, Avon) 2018 Dec 5;61:120-128. Epub 2018 Dec 5.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health and Science Technology, Faculty of Medicine, Aalborg University, Denmark.

Background: Patients with neck pain normally showed alterations in cervical motion and pressure pain sensitivity. Cervical joints show scattered motions opposite to (anti-directional) the primary motion direction (pro-directional) during dynamic cervical flexion and extension. This study aimed to assess dynamic cervical joint motion and pressure pain sensitivity when pain originated from different cervical muscles which may have clinical relevance in diagnosis of impairments related with neck pain. Read More

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December 2018

Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis.

Biomaterials 2018 Dec 5;192:579-589. Epub 2018 Dec 5.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Chemistry, Jinan University, Guangzhou, 510632, China. Electronic address:

The effective design of a targeted drug delivery system could improve the therapeutic efficacy of anticancer drugs by reducing their undesirable adsorption and toxic side effects. Here, an RGD-peptide functionalized and bioresponsive ruthenium prodrug (Ru-RGD) was designed for both cancer therapy and clinical diagnosis. This prodrug can be selectively delivered to cervical tumor sites to enhance theranostic efficacy. Read More

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December 2018

Pre-treatment patient characteristics as predictors of drop-out and treatment outcome in individual and family therapy for adolescents and adults with anorexia nervosa: A systematic review and meta-analysis.

Psychiatry Res 2018 Dec 2;271:484-501. Epub 2018 Dec 2.

Department of Clinical, Educational, and Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK; North East London Foundation Trust, London, UK.

Understanding variables predicting drop-out or unfavourable outcome following treatment for anorexia nervosa (AN) may help to improve upon intervention efforts. However, the current literature has demonstrated sparse and inconsistent significant findings. The current systematic review and meta-analysis summarised the evidence base examining baseline predictors of drop-out and outcome in AN treatment. Read More

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December 2018

Vestibular dysfunction as cortical damage with amyotrophic lateral sclerosis.

J Neurol Sci 2018 Dec 5;397:4-8. Epub 2018 Dec 5.

Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Cortical damage in areas such as the frontal lobe is reported in amyotrophic lateral sclerosis (ALS). However, aside from executive dysfunction, the pathological significance of this cortical damage has yet to be clarified. The present study investigated the effects of cortical damage on vestibular function in ALS. Read More

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December 2018

Antibody recognition by a novel microgel photonic crystal.

Bioorg Chem 2018 Dec 5;84:389-393. Epub 2018 Dec 5.

Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, China.

In this study, a easy-to-prepare biosensor for the sensitive detection of the antibody (Ab) protein was developed using a novel microgel photonic crystal (MPC). The MPC was fabricated by the spin-coated self-assembly method with the monodisperse Ab-sensitive poly (methyl methacrylate-acrylamide-glutaraldehyde-hapten) (P(MMA-AM-GA-HP)) microgels. Morphology characterization showed that the P(MMA-AM-GA-HP) microgels possessed round shapes and the large specific surface area, and the formed MPC had a highly ordered three dimensional (3D) periodically-ordered structure with the desired structural color. Read More

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December 2018

Estimating the probability of abusive head trauma after abuse evaluation.

Child Abuse Negl 2018 Dec 11;88:266-274. Epub 2018 Dec 11.

Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.

Background: Evidence-based, patient-specific estimates of abusive head trauma probability can inform physicians' decisions to evaluate, confirm, exclude, and/or report suspected child abuse.

Objective: To derive a clinical prediction rule for pediatric abusive head trauma that incorporates the (positive or negative) predictive contributions of patients' completed skeletal surveys and retinal exams.

Participants And Setting: 500 acutely head-injured children under three years of age hospitalized for intensive care at one of 18 sites between 2010 and 2013. Read More

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December 2018

Piloting a practice model in a Norwegian nursing home- A student-managed ward: A way to empower students for the nursing role.

Nurse Educ Pract 2018 Nov 29;34:161-166. Epub 2018 Nov 29.

Department of Nursing and Health Promotion, OsloMet - Oslo Metropolitan University, Norway; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

This paper focuses on the experiences of nursing students on a student-managed ward, the purpose of which was to empower students for the nursing role. Five nursing students operated and managed a nursing home ward for eight weeks during their final year of nursing education. The students claimed that a group of five students was beneficial. Read More

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November 2018

A prediction method of speed-dependent walking patterns for healthy individuals.

Gait Posture 2018 Dec 5;68:280-284. Epub 2018 Dec 5.

Federal University of ABC, Neuroscience and Biomedical Engineering Programs, São Bernardo do Campo, São Paulo, Brazil. Electronic address:

Background: Gait speed is one of the main biomechanical determinants of human movement patterns. However, in clinical gait analysis, the effect of gait speed is generally not considered, and people with disabilities are usually compared with able-bodied individuals even though disabled people tend to walk slower.

Research Questions: This study proposes a simple way to predict the gait pattern of healthy individuals at a specific speed. Read More

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December 2018

Multi-segment spine kinematics: Relationship with dance training and low back pain.

Gait Posture 2018 Dec 4;68:274-279. Epub 2018 Dec 4.

Centre for Sport Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia; Sport Performance Research Institute New Zealand, Auckland University of Technology, 17 Antares Place, Rosedale, Auckland 0632, New Zealand. Electronic address:

Background: Spine posture, range of motion (ROM) and movement asymmetry can contribute to low back pain (LBP). These variables may have greater impact in populations required to perform repetitive spine movements, such as dancers; however, there is limited evidence to support this.

Research Question: What is the influence of dance and LBP on spinal kinematics?

Methods: In this cross-sectional study, multi-segment spinal kinematics were examined in 60 female participants, including dancers (n = 21) and non-dancers (n = 39) with LBP (n = 33) and without LBP (n = 27). Read More

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December 2018
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6th vital sign app: Testing validity and reliability for measuring gait speed.

Gait Posture 2018 Dec 5;68:264-268. Epub 2018 Dec 5.

Kinesiology Department, California State University, Monterey Bay, 100 Campus Center, Seaside, CA, 93955, USA. Electronic address:

Background: Gait speed tests are useful predictors of different health outcomes in people. These tests can be administered by the convenience of one's smartphone.

Research Question: Is the 6th Vital Sign app valid and reliable for measuring gait speed?

Methods: The study used a prospective test-retest design. Read More

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December 2018

The relationship between trunk position sense and postural control in ataxic individuals.

Gait Posture 2018 Dec 6;68:258-263. Epub 2018 Dec 6.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.

Background: The proprioceptive system plays a role in the maintenance of postural control more than the visual and vestibular systems in ataxic patients with postural control disorders, but the relationship between trunk proprioception and postural control has not been sufficiently investigated yet. This relationship can provide a different perspective to the ataxia rehabilitation.

Research Question: This study aimed to examine the relationship between trunk position sense and postural control in ataxic individuals by comparing them to healthy individuals. Read More

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December 2018

Syngeneic, in contrast to allogeneic, mesenchymal stem cells have superior therapeutic potential following spinal cord injury.

J Neuroimmunol 2018 Nov 16;328:5-19. Epub 2018 Nov 16.

Department of Neurology and Neurosurgery, Karolinska University Hospital, BioClinicum, Solnavägen 30, Solna, Stockholm 17176, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna 17176, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Solna 17176, Stockholm, Sweden. Electronic address:

We evaluated the importance of histocompatibility of transplanted MSCs in terms of therapeutic potential. Mouse syngeneic MSCs or allogeneic MSCs were transplanted following SCI in mouse. In this study we found that syngeneic, but not allogeneic, MSCs alternatively activated macrophages resulting in a down-regulation of pro-inflammation. Read More

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November 2018

The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study.

Int Immunopharmacol 2018 Dec 11;67:145-151. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Wen Zhou Medical University, 109, Xueyuanxi Road, 325027 Wenzhou, China. Electronic address:

Background: Osteoarthritis (OA) is a type of degenerative joint disease affecting millions of individuals worldwide. However, there are currently no great inflammatory treatments available for it. Sophocarpine (SPC), one of the key bioactive compounds derived from Sophora flavescens, has shown remarkable anti-inflammatory effects. Read More

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December 2018

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

Int Immunopharmacol 2018 Dec 10;67:138-144. Epub 2018 Dec 10.

Institute of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining, China. Electronic address:

Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcumin is connected to its anti-inflammatory features. Read More

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December 2018

Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia-reperfusion injury.

Biomed Pharmacother 2018 Dec 11;111:1-5. Epub 2018 Dec 11.

Department of Cardiology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 20025, PR China. Electronic address:

The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia-reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human IL-1Ra (rhIL-1Ra) provides a protective role against myocardial I/R injury. Read More

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December 2018

Normal axillary thickness thresholds as a metric for nutritional status of children.

Clin Imaging 2018 Dec 1;54:57-62. Epub 2018 Dec 1.

Department of Radiology, University of Michigan Medical School, 3208C Medical Sciences Building 1, B1D502, Ann Arbor, MI 48109-5030, United States of America. Electronic address:

Introduction: Childhood pneumonia is a major cause of death in the 3rd world, and undernourishment increases the severity of the condition. We considered axillary thickness as a simple measurement to evaluate nutritional status that can be performed simultaneously with lung ultrasound. Our goal was to determine the distribution of axillary thickness in a cohort of children to determine a threshold for malnutrition. Read More

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December 2018

Attentional bias modification reduces clinical depression and enhances attention toward happiness.

J Psychiatr Res 2018 Dec 1;109:145-155. Epub 2018 Dec 1.

Department of Psychology, The Third Military Medical University, Chongqing, 400038, China.

Difficulty in clinical antidepressant treatment leads to the pursuit of alternative treatments, such as cognitive-behavior therapy (CBT). CBT combined with regular antidepressants have indicated an optimal therapeutic effect in clinic. Attentional bias is important in the occurrence and remission of depression, however, few studies have explored the effect of attentional bias modification (ABM) on depression, and inconsistent results have been obtained due to the heterogeneity in the targeted populations, training tasks, strategies, and materials. Read More

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December 2018

Characterization of cytokine gene expression in uterine cytobrush samples of non-endometritic versus endometritic postpartum dairy cows.

Theriogenology 2018 Dec 5;126:128-139. Epub 2018 Dec 5.

Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada.

To better understand uterine inflammation in postpartum dairy cows we collected sequential cytobrush samples at 29-35 and at 49-55 d in milk (DIM). Based on the uterine cytology, cows were classified as Non-endometritic (n = 23; <18% neutrophils) or Endometritic (n = 12; ≥18% neutrophils) at 29-35 DIM and Non-endometritic (n = 17; <10% neutrophils) or Endometritic (n = 9; ≥10% neutrophils) at 49-55 DIM. Cows defined as Sham Controls (n = 6) were examined by vaginoscopy at 29-35 DIM and identified as Non-endometritic (<10% neutrophils) at 49-55 DIM. Read More

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December 2018

Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2018 Sep 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. Read More

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September 2018

Do wearable sensors add meaningful information to the Timed Up and Go test? A study on obese women.

J Electromyogr Kinesiol 2018 Dec 5;44:78-85. Epub 2018 Dec 5.

Rehabilitation Unit and Research Lab in Biomechanics and Rehabilitation, S Giuseppe Hospital, Istituto Auxologico Italiano, Piancavallo, VB, Italy.

The purpose of this study was to validate Time Up and Go test (TUG) as measured by a single Inertial Measurement Unit (IMU) placed on the lower back to that measured by a stopwatch in obese and normal weight women; in addition, the comparison of the performance of TUG test between obese and healthy women using the instrumented TUG (iTUG). Forty-four severely obese women and 14 age-matched healthy women were assessed simultaneously by IMU and stopwatch. The comparison between manual and instrumented assessment of total time duration showed no significant differences both in the healthy (8. Read More

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December 2018

Lacking evidence for the association between frequent urine drug screening and health outcomes of persons on opioid agonist therapy.

Int J Drug Policy 2018 Dec 11;64:30-33. Epub 2018 Dec 11.

British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin 4, Ireland. Electronic address:

Background: Opioid agonist therapy (OAT) is a first-line treatment for opioid use disorder (OUD); however, the efficacy and role of urine drug screening (UDS) in OAT has received little research attention. Prior evidence suggests that UDS frequency reflects philosophy and practice context rather than differences in patient characteristics or clinical need. Therefore, we reviewed the literature on the effect of and recommendations for the frequency of UDS on health outcomes for persons with OUD who receive OAT. Read More

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December 2018
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