4,359,547 results match your criteria Clinical Pharmacist[Journal]


[Clinical features, treatment distribution and outcomes of Mooren's ulcer].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):127-133

Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.

To investigate the clinical features, treatment distribution and transition of Mooren's ulcer, and to observe the clinical outcomes and recurrence. Retrospective series case study. Medical records of 125 patients (154 eyes) with Mooren's ulcer treated between January 1996 and December 2015 at our hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.011DOI Listing
February 2019

[Clinical outcomes after laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) in myopia].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):122-126

Peking Union Medical College Hospital, Beijing 100730, China.

To compare the clinical outcomes between laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) for treatment of myopia. Case-control study. We reviewed a total of 90 right eyes that underwent either LASEK or TPRK, with 45 eyes in each group (aged between 18 and 40 years; 9 males and 16 females in the LASEK group, and 30 males and 15 females in the TPRK group) from 2015 to 2016 in Peking Union Medical College Hospital and Tangshan Eye Hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.010DOI Listing
February 2019

[The effect of corneal biomechanical properties on opaque bubble layer in small incision lenticule extraction (SMILE)].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):115-121

Tianjin Medical University, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China.

To investigate the influence of corneal biomechanical properties on opaque bubble layer (OBL) in small incision lenticule extraction (SMILE). In this nested case control study, 20 patients (31 eyes) were enrolled in OBL group, while 51 patients (98 eyes) were included in non-OBL group. The parameters were obtained by Pentacam HR and Corvis ST examinations. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.009DOI Listing
February 2019

[Clinical study on microcirculation changes of bulbar conjunctiva after contact lens wear].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):98-104

School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, China.

To explore the changes of microcirculation of the bulbar conjunctiva after wearing the contact lens and the relationship between contact lens discomfort and bulbar conjunctiva microcirculation. Prospective cohort study. The postgraduate students from School of Ophthalmology & Optometry and School of Biomedical Engineering of Wenzhou Medical University were included in this prospective cohort study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.006DOI Listing
February 2019

[From evidence to clinical practice: myopia control among children in refraction clinics].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):89-92

Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China.

Over the past decade, breakthrough has been made on myopia progression control with a lot of evidence from clinical trials, but the effective clinical application of many of them remained immature. Though refraction clinics have been set up in many specialized hospitals offering spectacles to correct refractive error, there was few protocol or standard of treatment for reducing myopia progression. This commentary reviews the latest and essential publications and presents critical advice on applying the research findings to clinical practice. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.003DOI Listing
February 2019

[Study on the risk factors for hemorrhagic transformation of cerebellar infarction after posterior fossa decompression surgery].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):380-383

Department of Neurosurgery, Jinhua Municipal Central Hospital, Jinhua 321000, China.

To investigate the related risk factors for hemorrhagic transformation (HT) of cerebellar infarction after posterior fossa decompression surgery. A total of 91 patients with cerebellar infarction were treated by posterior fossa decompression surgery in Department of Neurosurgery of Jinhua Municipal Central Hospital from Jan 2010 to Jan 2018, were selected as study subjects. The HT group included 17 cases, while the Non-HT group included 74 cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.012DOI Listing
January 2019

[Evaluation of the effect of electrical stimulation combined with biofeedback therapy for postpartum pelvic organ prolapse: a static and dynamic magnetic resonance imaging study].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):375-379

Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.

To explore the clinical value of static and dynamic magnetic resonance imaging (MRI) in evaluating the effect of electrical stimulation combined with biofeedback in the treatment of pelvic organ prolapse postpartum. A total of 50 primiparas diagnosed as pelvic organ prolapse postpartum from February 2016 to November 2017 were randomly divided into treatment group (24 cases) and control group (26 cases). The control group recovered spontaneously, and the treatment group received electric stimulation combined with biofeedback therapy (6 weeks). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.011DOI Listing
January 2019

[PLA2G6 compound complicated mutation in an atypical neuroaxonal dystrophy pedigree].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):354-358

Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.

To analyze the clinical presentation, imaging features, and the mutation of the pathogenic genes in a Chinese Han atypical neuroaxonal dystrophy pedigree. A family of atypical neuroaxonal dystrophy pedigree who came to Henan Provincal People's Hospital in July 2016 was included. Clinical presentation, imaging features of the pedigree were analyzed, and all exon gene detection of the proband was performed to capture the target variations, then verified by sanger sequence. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.007DOI Listing
January 2019

[Efficacy and mechanism of loading dose clopidogrel in patients with transient ischemic attack and minor stroke].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):349-353

Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215000, China.

To assess outcome, safety and possible mechanism of loading dose clopidogrel in patients with transient ischemic attack (TIA) and minor stroke. We reviewed patients with confirmed TIA and minor stroke admitted between July 2016 and December 2017 into the First Affiliated Hospital of Soochow University. Loss-of-function allele carriers of CYP2C19 were included and randomly divided into loading dose group (first dose of 300 mg clopidogrel) and standard dose group (first dose of 75 mg clopidogrel), 100 mg aspirin was gave at the same time, followed by aspirin 100 mg/d plus clopidogrel 75 mg/d maintaining for 20 days. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.006DOI Listing
January 2019

[Magnetic resonance imaging study of endolymphatic hydrops based on 3D-FLAIR sequence after single-dose intravenous gadolinium injection].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):333-337

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the visualization of endolymph in patients with otogenic vertigo by intravenous administration of single dose of gadolinium contrast agents and magnetic resonance three-dimensional fluid-attenuated inversion recovery sequence (3D-FLAIR MRI), and further assess the extent of endolymphatic hydrops. From Beijing Tongren Hospital of Capital Medical University between October 2017 and June 2018, 30 patients (16 males, 14 females) with unilateral otogenic vertigo were involved in this study, with the age of 30 to 68 years, mean age of (53±10) years. Eight hours after intravenous administration of single dose (0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.003DOI Listing
January 2019

[The role of food in prevention and correction of iodine deficiency in the endemic territory].

Vopr Pitan 2018 13;87(5):27-36. Epub 2018 Sep 13.

Industrial University of Tyumen.

Iodine supply remains the global problem due to the wide prevalence and a wide range of clinical manifestations in all age groups of population. However, iodine deficiency is a nutritional deficiency and the solution of this problem lies in the organization of rational nutrition of the population. The purpose of this study was to examine the food features of the population of the mild iodine-deficient region from the standpoint of adequacy of iodine sufficiency. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10050DOI Listing
September 2018

Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome.

Isr Med Assoc J 2019 Feb;21(2):124-125

Department of Internal Medicine, Meir Medical Center, Kfar Saba, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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February 2019

Hospitalization for Respiratory Syncytial Virus Bronchiolitis in the Palivizumab Prophylaxis Era: Need for Reconsideration of Preventive Timing and Eligibility.

Isr Med Assoc J 2019 Feb;21(2):110-115

Department of Pediatrics A, Schneider Children's Medical Center, Petah Tikva, Israel.

Background: Respiratory syncytial virus (RSV)-related bronchiolitis is a common cause of morbidity in young infants. The recommendations for its passive prevention by palivizumab are currently under intensive debate.

Objectives: To elucidate the optimal prevention strategy by studying the morbidity of RSV disease under the current recommendations for palivizumab prophylaxis in Israel. Read More

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February 2019

Ga-PSMA PET/CT Staging of Newly Diagnosed Intermediate- and High-Risk Prostate Cancer.

Isr Med Assoc J 2019 Feb;21(2):100-104

Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services.

Objectives: To assess the incidence of metastatic spread in consecutive patients with newly diagnosed cancer, and the potential added value of Ga-PSMA PET/CT to the staging imaging algorithm.

Methods: Patients with newly diagnosed intermediate- and high-risk prostate cancer were referred for initial staging by Ga-PSMA PET/CT between May 2016 and April 2017. Read More

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February 2019

Maternal and Neonatal Complications of Pregnant Women with Mitral Stenosis.

Isr Med Assoc J 2019 Feb;21(2):88-93

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Background: Rheumatic mitral stenosis (MS) is a relatively rare diagnosis in the developed countries and its treatment during pregnancy is challenging due to hemodynamic changes. With the demographic changes due to recent waves of immigration an increase in the prevalence of rheumatic heart disease is expected.

Objectives: To evaluate maternal and neonatal complications in patients with mitral stenosis. Read More

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February 2019

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

Circle of Willis variations in migraine patients with ischemic stroke.

Brain Behav 2019 Feb 16:e01223. Epub 2019 Feb 16.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.

Materials And Methods: Participants were recruited from the prospective Dutch acute Stroke Study. Read More

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http://dx.doi.org/10.1002/brb3.1223DOI Listing
February 2019

Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non-alcoholic fatty liver disease mice.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Gastroenterology, Peking University People's Hospital, Beijing, P.R. China.

Mesenteric adipose tissue (MAT) inflammation is associated with non-alcoholic fatty liver disease (NAFLD), and immune cells play pivotal roles in the inflammation of adipose tissue. Here, we investigated the roles of MAT B lymphocytes in NAFLD. Mice fed with high-fat diet (HFD) and normal diet (ND) were killed in time gradients (4, 8 and 12 weeks). Read More

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http://dx.doi.org/10.1111/jcmm.14232DOI Listing
February 2019

The latest progress on miR-374 and its functional implications in physiological and pathological processes.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Non-coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non-coding RNAs (lncRNAs >200nt), stable non-coding RNAs (60-300nt), microRNAs (miRs or miRNAs, 18-24nt), circular RNAs, piwi-interacting RNAs (26-31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14219DOI Listing
February 2019

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC-derived extracellular vesicles (hUCMSC-EVs) in peripheral nerve regeneration, however, remains unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14190DOI Listing
February 2019

The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Infect Dis Ther 2019 Feb 16. Epub 2019 Feb 16.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.

Introduction: The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).

Methods: A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area hospitals was performed. Read More

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http://dx.doi.org/10.1007/s40121-019-0237-2DOI Listing
February 2019

Sex-dependent differences for larkspur (Delphinium barbeyi) toxicosis in yearling Angus cattle1.

J Anim Sci 2019 Feb 17. Epub 2019 Feb 17.

USDA-ARS, Poisonous Plant Research Laboratory, Logan, UT.

Larkspur (Delphinium spp.) poisoning is a long-term problem for cattle grazing on rangelands of western North America. Results from preliminary experiments have suggested that differences in larkspur toxicity may exist between heifers and bulls. Read More

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http://dx.doi.org/10.1093/jas/skz002DOI Listing
February 2019

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

JAMA 2019 Feb 17. Epub 2019 Feb 17.

Departmento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago.

Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.

Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality. Read More

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http://dx.doi.org/10.1001/jama.2019.0071DOI Listing
February 2019

Untargeted Metabolomics and Inflammatory Markers Profiling in Children With Crohn's Disease and Ulcerative Colitis-A Preliminary Study.

Inflamm Bowel Dis 2019 Feb 17. Epub 2019 Feb 17.

Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.

Background: Metabolic profiling might be used to identify disease biomarkers. The aim of our study was to determine the usefulness of untargeted metabolomics analysis to detect differences in serum metabolites between newly diagnosed and untreated pediatric patients with Crohn's disease (CD) or ulcerative colitis (UC) in comparison with a control group (Ctr). Moreover, we investigated the potential of profiling metabolomics and inflammatory markers to improve the noninvasive diagnosis of CD and UC in children. Read More

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http://dx.doi.org/10.1093/ibd/izy402DOI Listing
February 2019

Dual role of TGF-B in early pregnancy: Clues from tumor progression.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

TGF-β signaling in the endometrium is active during the implantation period and has a pivotal role in regulating endometrial receptivity and embryo implantation. During embryo implantation, both apoptosis and proliferation of endometrial cells happen at the same time and it seems TGF-β is the factor that controls both of these processes. As shown in cancer cells, in special conditions this cytokine can have a dual effect and switch the action from apoptosis to proliferation. Read More

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http://dx.doi.org/10.1093/biolre/ioz024DOI Listing
February 2019

Sarcopenia and variation in the Human Leukocyte Antigen complex.

J Gerontol A Biol Sci Med Sci 2019 Feb 17. Epub 2019 Feb 17.

Epidemiology and Public Health Group, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, UK.

Background: Aging is characterized by chronic inflammation plus muscle mass and strength loss, termed sarcopenia. Human Leukocyte Antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants associate with sarcopenia in autoimmune disease free older people. Read More

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http://dx.doi.org/10.1093/gerona/glz042DOI Listing
February 2019

Effectiveness of individual and group multicomponent interventions for smoking cessation in primary care: a quasi-experimental study.

Fam Pract 2019 Feb 17. Epub 2019 Feb 17.

Servicio Extremeño de Salud, Centro de Salud Universitario 'La Paz', Unidad Docente de Medicina Familiar y Comunitaria, Departamento de Ciencias Biomédicas, Universidad de Extremadura, Badajoz, Spain.

Background: The efficacy of smoking cessation interventions can be quite diverse in day-to-day clinical practice.

Objective: To analyse the effectiveness in smoking cessation of multicomponent interventions carried out in groups or individually in primary care practices.

Methods: A quasi-experimental, multicentre study of 12-month follow-up of patients treated in multicomponent smoking cessation interventions was carried out in Urban health care centres in Sevilla, Spain. Read More

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http://dx.doi.org/10.1093/fampra/cmz005DOI Listing
February 2019

Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.

Med Sci Monit 2019 Feb 17;25:1283-1290. Epub 2019 Feb 17.

Department of Hand and Pediatric Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. Read More

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http://dx.doi.org/10.12659/MSM.913069DOI Listing
February 2019

[Giant Aneurysm of the Left Sinus of Valsalva Accompanied by Left Main Coronary Artery Compression, Myocardial Ischemia, Pericardial Tamponade].

Kyobu Geka 2019 Feb;72(2):99-103

Department of Cardiovascular Surgery, Yokkaichi Municipal Hospital, Yokkaichi, Japan.

Left sinus of Valsalva aneurysm(SVAn)is a very rare clinical entity. We present a 68-year-old female with left SVAn, 5 cm in diameter, compressing the left main coronary artery and causing antero-septal asynergy. She also had massive pericardial effusion, moderate to severe(grade Ⅲ)aortic regurgitation, and mitral regurgitation. Read More

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February 2019

[Clinical Assessment of Fourteen Cases of Thoracic Endometriosis].

Kyobu Geka 2019 Feb;72(2):87-91

Division of Thoracic Surgery,Tohoku Medical and Pharmaceutical University, Sendai, Japan.

We retrospectively assessed the clinical and pathological features of 14 patients with thoracic endometriosis who were treated at our hospital from 2007 to 2017. Thirteen patients presented pneumothorax and 1 patient presented bloody sputum. All were treated surgically. Read More

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February 2019

Scaffolding clinical reasoning of medical students with virtual patients: effects on diagnostic accuracy, efficiency, and errors.

Diagnosis (Berl) 2019 Feb 18. Epub 2019 Feb 18.

Medizinische Klinik und Polklinik IV, University Hospital, LMU Munich, Munich, Germany.

Background Understanding clinical reasoning is a major challenge in medical education research. Little is known about the influence of scaffolding and feedback on the clinical reasoning of medical students. The aim of this study was to measure the effects of problem representation (cognitive representation of a clinical case) and structured scaffolding for reflection with or without feedback on the diagnostic efficiency and characterization of diagnostic errors of medical students. Read More

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http://dx.doi.org/10.1515/dx-2018-0090DOI Listing
February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

Defining compassion in the digital health age: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e026338. Epub 2019 Feb 15.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Introduction: The notion of compassion and compassionate care is playing an increasingly important role in health professional education and in the delivery of high-quality healthcare. Digital contexts, however, are not considered in the conceptualisation of compassionate care, nor is there guidance on how compassionate care is to be exercised while using digital health technologies. The widespread diffusion of digital health technologies provides new contexts for compassionate care, with both opportunities for new forms and instantiations of compassion as well as new challenges. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026338DOI Listing
February 2019

Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer.

BMJ Open 2019 Feb 15;9(2):e025483. Epub 2019 Feb 15.

Centre for Research in Health and Social Care Management (CERGAS), SDA Bocconi, Milano, Italy.

Introduction: Mobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients' symptoms. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025483DOI Listing
February 2019

Medical management of acute upper respiratory infections in an urban primary care out-of-hours facility: cross-sectional study of patient presentations and expectations.

BMJ Open 2019 Feb 15;9(2):e025396. Epub 2019 Feb 15.

Graduate Entry Medical School, University of Limerick Faculty of Education and Health Sciences, Limerick, Ireland.

Objectives: The purpose of this study was to examine the expectations of patients attending an urban primary care out-of-hours (OOH) facility with acute upper respiratory tract infection (acute URTI) regarding clinical examination, symptom management, information on their condition, reassurance, antibiotic treatment and other possible options including referral.

Design: Cross-sectional design.

Setting: One urban primary care OOH facility located in the midwest of Ireland. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025396DOI Listing
February 2019

Systematic review of clinical outcome reporting in randomised controlled trials of burn care.

BMJ Open 2019 Feb 15;9(2):e025135. Epub 2019 Feb 15.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Introduction: Systematic reviews collate trial data to provide evidence to support clinical decision-making. For effective synthesis, there must be consistency in outcome reporting. There is no agreed set of outcomes for reporting the effect of burn care interventions. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025135DOI Listing
February 2019

Breastfeeding and behavioural problems: Propensity score matching with a national cohort of infants in Chile.

BMJ Open 2019 Feb 15;9(2):e025058. Epub 2019 Feb 15.

Psychology School, Pontificia Universidad Católica de Chile, Santiago, Chile.

Importance: Potential effects of breast feeding on children's behaviour remains an elusive debate given inherent methodological challenges. Propensity score matching affords benefits by ensuring greater equivalence on observable social and health determinants, helping to reduce bias between groups.

Objectives: We examined whether the duration of breast feeding had an impact on children's externalising and internalising behaviours. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025058DOI Listing
February 2019

Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder: a pilot randomised controlled trial with long-term follow-up.

BMJ Open 2019 Feb 15;9(2):e024685. Epub 2019 Feb 15.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Objective: Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format.

Design: A pilot, single-blind, parallel group randomised controlled trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024685DOI Listing
February 2019

Quality of reporting of outcomes in trials of therapeutic interventions for pressure ulcers in adults: a protocol for a systematic survey.

BMJ Open 2019 Feb 15;9(2):e024633. Epub 2019 Feb 15.

Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.

Pressure ulcers (PUs) have a high incidence, especially in hospital units. Randomised clinical trials (RCTs) of therapeutic interventions for PU should include a clear description of the outcomes and results to enhance transparency and replicability.

Objectives: The primary objective of this study is to assess the completeness of the descriptions of the outcomes of therapeutic interventions in RCTs in adult patients with PU. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024633DOI Listing
February 2019

Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial.

BMJ Open 2019 Feb 15;9(2):e023765. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Introduction: Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative colitis (UC) that warrants hospitalisation. Despite significant advances in therapeutic options for UC and in the medical management of steroid-refractory ASUC, the initial treatment paradigm has not changed since 1955 and is based on the use of intravenous corticosteroids. This treatment is successful in approximately 50% of patients but failure of this and subsequent medical therapy still occurs, with colectomy rates of up to 40% reported. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023765DOI Listing
February 2019

Can a tool developed for industry be used to assess fatigue risk in medical rotas? A pilot study of foundation doctors' rotas in a tertiary centre.

BMJ Open 2019 Feb 15;9(2):e023470. Epub 2019 Feb 15.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Objectives: To determine the feasibility and ease of using a pre-existing health and safety executive fatigue risk calculator to assess doctors' rotas.

Design: Observational.

Setting: A large tertiary-referral teaching hospital in the UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023470DOI Listing
February 2019

Can differences in length of stay between Dutch university hospitals and other hospitals be explained by patient characteristics? A cross-sectional study.

BMJ Open 2019 Feb 15;9(2):e021851. Epub 2019 Feb 15.

Radboud Institute for Health Sciences, IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: The indicator unexpectedly long length of stay (UL-LOS) is used to gain insight into quality and safety of care in hospitals. The calculation of UL-LOS takes patients' age, main diagnosis and main procedure into account. University hospitals have relatively more patients with a UL-LOS than other hospitals. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021851DOI Listing
February 2019

Conversion of other opioids to methadone: a retrospective comparison of two methods.

BMJ Support Palliat Care 2019 Feb 16. Epub 2019 Feb 16.

Department of Supportive and Palliative Care, Mater Health Services, Brisbane, Queensland, Australia

Context: A rapid method of methadone conversion known as the Perth Protocol is commonly used in Australian palliative care units. There has been no follow-up or validation of this method and no comparison between different methods of conversion.

Objectives: The primary objective of this study was to test the hypothesis that the achieved doses of methadone are independent of the conversion method (rapid vs slower). Read More

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http://dx.doi.org/10.1136/bmjspcare-2018-001645DOI Listing
February 2019

Does One Health require a novel ethical framework?

J Med Ethics 2019 Feb 16. Epub 2019 Feb 16.

Australian Centre for Health Engagement, Evidence and Values, University of Wollongong, Wollongong, New South Wales, Australia.

Emerging infectious diseases (EIDs) remain a significant and dynamic threat to the health of individuals and the well-being of communities across the globe. Over the last decade, in response to these threats, increasing scientific consensus has mobilised in support of a One Health (OH) approach so that OH is now widely regarded as the most effective way of addressing EID outbreaks and risks. Given the scientific focus on OH, there is growing interest in the philosophical and ethical dimensions of this approach, and a nascent OH literature is developing in the humanities. Read More

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http://dx.doi.org/10.1136/medethics-2018-105043DOI Listing
February 2019

Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery.

Gut 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Objective: Postprandial hyperinsulinaemia after Roux-en Y gastric bypass (GB) has been attributed to rapid nutrient flux from the gut, and an enhanced incretin effect. However, it is unclear whether surgery changes islet cell responsiveness to regulatory factors. This study tested the hypothesis that β-cell sensitivity to glucagon like-peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) is attenuated after GB. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317760DOI Listing
February 2019

Impact of gene-specific germline pathogenic variants on presentation of endometrial cancer in Lynch syndrome.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Objective: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer.

Methods: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000277DOI Listing
February 2019

Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland.

Heart 2019 Feb 16. Epub 2019 Feb 16.

Paediatric Cardiac Surgery, Birmingham Children's Hospital, Birmingham, UK.

Objective: To evaluate time trends in the use of catheter and surgical procedures, and associated survival in isolated congenital shunt lesions.

Methods: Nationwide, retrospective observational study of the UK National Congenital Heart Disease Audit database from 2000 to 2016. Patients undergoing surgical or catheter procedures for atrial septal defect (including sinus venosus defect), patent foramen ovale, ventricular septal defect and patent arterial duct were included. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314428DOI Listing
February 2019

Twelve-month analgesia and rescue, by cooled radiofrequency ablation treatment of osteoarthritic knee pain: results from a prospective, multicenter, randomized, cross-over trial.

Reg Anesth Pain Med 2019 Feb 16. Epub 2019 Feb 16.

Center for Clinical Research, Winston Salem, North Carolina, USA

Background And Objectives: As a follow-up to the 6-month report,12 this study investigated the analgesic effect of cooled radiofrequency ablation (CRFA) in patients with knee osteoarthritis (OA) 12 months postintervention and its ability to provide pain relief in patients who experienced unsatisfactory effects of intra-articular steroid injection (IAS).

Methods: Seventy-eight per cent (52/67) of patients originally treated with CRFA were evaluated at 12 months, while at 6 months post-IAS, 82% (58/71) of those patients crossed over to CRFA and assessed 6 months later.

Results: At 12 months, 65% of the original CRFA group had pain reduction ≥50%, and the mean overall drop was 4. Read More

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http://dx.doi.org/10.1136/rapm-2018-100051DOI Listing
February 2019

Use of a maternal newborn audit and feedback system in Ontario: a collective case study.

BMJ Qual Saf 2019 Feb 16. Epub 2019 Feb 16.

Better Outcomes Registry & Network (BORN), Children's Hospital of Eastern Ontario - Ottawa Children's Treatment Centre (CHEO-OCTC), Ottawa, Ontario, Canada.

Background: As part of a larger study examining the effectiveness of the Maternal Newborn Dashboard, an electronic audit and feedback system to improve maternal-newborn care practices and outcomes, the purpose of this study was to increase our understanding of factors explaining variability in performance after implementation of the Dashboard in Ontario, Canada.

Methods: A collective case study. A maximum variation sampling approach was used to invite hospitals reflecting different criteria to participate in a 1-day to 2-day site visit by the research team. Read More

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http://dx.doi.org/10.1136/bmjqs-2018-008354DOI Listing
February 2019

Efficacy and side effect of curcumin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trials.

Pak J Pharm Sci 2019 Jan;32(1):43-51

Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China.

This meta-analysis aimed to confirm the efficacy and safety (side effect) of curcumin for osteoarthritis (OA). Two researchers independently searched the database of Pub Med, EMBASE and Cochrane Library updated to November 2015 to find randomized controlled trials that reported the effect of curcumin on OA. The outcomes of this meta-analysis were Visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index scale (WOMAC) and side effect. Read More

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January 2019
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